MCID: THR007
MIFTS: 31

Thrombophlebitis Migrans

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Thrombophlebitis Migrans

MalaCards integrated aliases for Thrombophlebitis Migrans:

Name: Thrombophlebitis Migrans 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:14392
ICD9CM 34 453.1
SNOMED-CT 67 31268005
ICD10 32 I82.1
UMLS 71 C0152250

Summaries for Thrombophlebitis Migrans

Disease Ontology : 12 A thrombophlebitis that is characterized by repeated occurances of thrombophlebitis in different locations.

MalaCards based summary : Thrombophlebitis Migrans is related to thrombosis and pulmonary embolism. An important gene associated with Thrombophlebitis Migrans is KIF25 (Kinesin Family Member 25), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Complement and coagulation cascades. Affiliated tissues include lymph node, lung and pancreas, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and embryo

Related Diseases for Thrombophlebitis Migrans

Diseases related to Thrombophlebitis Migrans via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 77)
# Related Disease Score Top Affiliating Genes
1 thrombosis 29.6 SERPINC1 P2RY12 F3 F2RL2
2 pulmonary embolism 29.5 SERPINC1 PDE5A F3
3 thrombophlebitis 11.9
4 maternal uniparental disomy 10.4 SLX4 FANCA
5 maternal uniparental disomy of chromosome 16 10.4 SLX4 FANCA
6 buerger disease 10.3
7 colitis 10.3
8 ulcerative colitis 10.3
9 acquired hemangioma 10.3 LYVE1 F3
10 heparin-induced thrombocytopenia 10.3 SERPINC1 F3
11 fournier gangrene 10.3 SERPINC1 F3
12 vulvar angiokeratoma 10.3 SERPINC1 F3
13 blue toe syndrome 10.3 SERPINC1 F3
14 dic in newborn 10.2 SERPINC1 F3
15 hepatic infarction 10.2 SERPINC1 F3
16 mitochondrial dna depletion syndrome 4b 10.2 POLG FANCI
17 giant hemangioma 10.2 SERPINC1 F3
18 marantic endocarditis 10.2 SERPINC1 F3
19 sensory ataxic neuropathy, dysarthria, and ophthalmoparesis 10.2 POLG FANCI
20 intracranial sinus thrombosis 10.2 SERPINC1 F3
21 leech infestation 10.2 SERPINC1 F3
22 prothrombin deficiency 10.2 SERPINC1 F3
23 volkmann contracture 10.2 SERPINC1 F3
24 sagittal sinus thrombosis 10.2 SERPINC1 F3
25 branch retinal artery occlusion 10.2 SERPINC1 F3
26 fanconi anemia, complementation group u 10.2 SLX4 FANCI FANCA
27 adenocarcinoma 10.2
28 pancreatic adenocarcinoma 10.2
29 fanconi anemia, complementation group v 10.2 SLX4 FANCI FANCA
30 intracranial embolism 10.2 SERPINC1 F3
31 fanconi anemia, complementation group i 10.2 POLG FANCI
32 fanconi anemia, complementation group r 10.2 SLX4 FANCI FANCA
33 fanconi anemia, complementation group t 10.2 SLX4 FANCI FANCA
34 fanconi anemia, complementation group q 10.2 SLX4 FANCI FANCA
35 fanconi anemia, complementation group o 10.2 SLX4 FANCI FANCA
36 fanconi anemia, complementation group p 10.2 SLX4 FANCI FANCA
37 splenic infarction 10.2 SERPINC1 F3
38 fanconi anemia, complementation group n 10.2 SLX4 FANCI FANCA
39 mitochondrial dna depletion syndrome 1 10.2 POLG FANCI
40 fanconi anemia, complementation group d1 10.2 SLX4 FANCI FANCA
41 fanconi anemia, complementation group j 10.2 SLX4 FANCI FANCA
42 esophageal atresia 10.2 SLX4 FANCI FANCA
43 congenital hypoplastic anemia 10.2 SLX4 FANCI FANCA
44 autosomal dominant progressive external ophthalmoplegia 10.1 POLG FANCI
45 carotid artery thrombosis 10.1 SERPINC1 F3
46 vitamin k deficiency bleeding 10.1 SERPINC1 F3
47 active peptic ulcer disease 10.1 P2RY12 F3
48 esophageal varix 10.1 SERPINC1 F3
49 post-thrombotic syndrome 10.1 SERPINC1 F3
50 cryofibrinogenemia, familial primary 10.0

Comorbidity relations with Thrombophlebitis Migrans via Phenotypic Disease Network (PDN):


Deficiency Anemia

Graphical network of the top 20 diseases related to Thrombophlebitis Migrans:



Diseases related to Thrombophlebitis Migrans

Symptoms & Phenotypes for Thrombophlebitis Migrans

GenomeRNAi Phenotypes related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.02 CHD1L F2RL2 FANCA FANCI XRCC1

MGI Mouse Phenotypes related to Thrombophlebitis Migrans:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.86 BRD1 F3 FANCA HHAT PINX1 POLG
2 hematopoietic system MP:0005397 9.85 BRD1 F2RL2 F3 FANCA LYVE1 P2RY12
3 mortality/aging MP:0010768 9.73 BRD1 F3 FANCA FANCI HHAT NCS1
4 neoplasm MP:0002006 9.1 F3 FANCA PINX1 POLG SIRT2 XRCC1

Drugs & Therapeutics for Thrombophlebitis Migrans

Search Clinical Trials , NIH Clinical Center for Thrombophlebitis Migrans

Genetic Tests for Thrombophlebitis Migrans

Anatomical Context for Thrombophlebitis Migrans

MalaCards organs/tissues related to Thrombophlebitis Migrans:

40
Lymph Node, Lung, Pancreas, Liver, Prostate

Publications for Thrombophlebitis Migrans

Articles related to Thrombophlebitis Migrans:

(show top 50) (show all 88)
# Title Authors PMID Year
1
Thrombophlebitis Migrans (Trousseau Syndrome) in Pancreatic Adenocarcinoma: An Autopsy Report. 61
31687303 2019
2
[Paraneoplastic syndromes]. 61
31283129 2019
3
Thrombophlebitis migrans in a man with pancreatic adenocarcinoma: a case report. 61
19829832 2009
4
[Superficial migratory thrombophlebitis: a clinical and histologic review of 8 cases]. 61
18501171 2008
5
Thrombophlebitis migrans as a footprint of Buerger's disease: a prospective-descriptive study in north-east of Iran. 61
17554578 2008
6
[Conservative management of thrombophlebitis. Cooling, wrapping and mobilizing the patient]. 61
12380352 2002
7
Low-molecular-weight heparin in the management of Trousseau's syndrome. 61
9264346 1997
8
Thrombophlebitis migrans in association with acute relapsing pancreatitis. 61
7613951 1995
9
[Thrombophlebitis migrans as the first symptom of a myelodysplastic syndrome]. 61
8271871 1993
10
[Thromboangiitis obliterans associated with small-vessel vasculitis]. 61
2622287 1989
11
Trousseau's syndrome caused by malignant degeneration of a choledochal cyst. 61
2552588 1989
12
Thrombophlebitis migrans following co-trimoxazole therapy. 61
2789377 1989
13
[A clinical case of thrombophlebitis migrans]. 61
3222318 1988
14
[Recurrent cerebral emboli in nonbacterial thrombotic endocarditis]. 61
3678075 1987
15
Thrombophlebitis migrans as a marker of malignancy. 61
3792254 1986
16
Clinical investigations on long-term activation of fibrinolysis by anabolic steroids. 61
2427405 1986
17
Cryoproteins. 61
3767197 1986
18
Occult cancer in patients with acute pulmonary embolism. 61
7073147 1982
19
[Isolated visceral thrombophlebitis migrans]. 61
7040283 1982
20
Thrombophlebitis migrans in association with ulcerative colitis. 61
7310913 1981
21
[Observation of a case of combined gastric carcinoma and thrombophlebitis migrans of the deep veins of the legs]. 61
7253489 1981
22
Thrombophlebitis migrans: a further systemic complication of ulcerative colitis. 61
7393815 1980
23
Carcinoma of the prostate presenting as thrombophlebitis migrans. 61
441875 1979
24
Prophylaxis of recurrent venous thrombosis with long-term enhancement of fibrinolysis. 61
94894 1979
25
Thrombophlebitis migrans in ulcerative colitis. 61
604994 1977
26
Recurrent venous thrombosis (thrombophlebitis migrans) and carcinoma of the lung. 61
887028 1977
27
[Thrombophlebitis migrans]. 61
905331 1977
28
Thrombophlebitis migrans. An unusual presentation as a collagen vascular disease--report of a case. 61
4147715 1973
29
[Behavior of thrombocytes under immunosuppressive and anticoagulant therapy in a case of thrombophlebitis migrans]. 61
4637708 1972
30
[Thrombophlebitis migrans and secondary papillary carcinoma of the lung]. 61
5119038 1971
31
[Determination of circulating auto-antibodies against fibrinogen in thrombophlebitis migrans]. 61
5485822 1970
32
Budd-Chiari syndrome caused by a web as a result of visceral thrombophlebitis migrans. Report of a case. 61
5439474 1970
33
[Thrombophlebitis migrans--an early mask of a neoplasm]. 61
5697951 1968
34
[Purpura fulminans in the pathological anatomical picture of a case of thrombophlebitis migrans et saltans]. 61
5640354 1968
35
Thrombophlebitis migrans associated with circulating antibodies against Fibrinogen. A case report. 61
4173215 1967
36
[NOSOLOGIC AND PATHOGENIC CONSIDERATIONS ON THROMBOPHLEBITIS MIGRANS. DESCRIPTION OF 2 CASES CORRELATED WITH DIAPHRAGMATIC HERNIA]. 61
14336340 1965
37
[Acute hemocytoblastic leukemia with unusual initial clinical picture: thrombophlebitis migrans]. 61
14461800 1962
38
[A case of periarteritis nodosa with thrombophlebitis migrans of the lower extremity]. 61
13981000 1962
39
[Thrombophlebitis migrans. Critical review and clinical contribution]. 61
13891256 1961
40
[Long-term treatment of thrombophlebitis migrans with phenylbutazone (Butazolidin, Geigy)]. 61
13712690 1961
41
A case of thrombophlebitis migrans. 61
13705312 1961
42
[Thrombophlebitis migrans and its pathogenetic relations to thromboangiitis obliterans]. 61
13736029 1961
43
Refractory thrombophlebitis migrans in malignant disease. 61
13840068 1960
44
[A compression syndrome of the inferior vena cava as a rare localization of thrombophlebitis migrans]. 61
13853821 1960
45
[On the pathogenesis of thrombophlebitis migrans in carcinoma]. 61
14407321 1960
46
[Clinical observations on thrombophlebitis migrans, with a case contribution]. 61
14443876 1960
47
[Association of Besnier-Boeck-Schaumann sarcoidosis with thrombophlebitis migrans. Description of a case]. 61
14431079 1959
48
[Arteriolitis. Thrombophlebitis migrans. Benign insular gangrene. Mutilating acropathy and rickettsiosis. Neo-rickettsiosis]. 61
14438530 1959
49
[Thrombophlebitis migrans of superficial veins during thromboangiitis obliterans]. 61
13601346 1958
50
[Significance of thrombophlebitis migrans as indication of latent carcinoma]. 61
13507445 1957

Variations for Thrombophlebitis Migrans

Expression for Thrombophlebitis Migrans

Search GEO for disease gene expression data for Thrombophlebitis Migrans.

Pathways for Thrombophlebitis Migrans

Pathways related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.51 SERPINC1 PDE5A P2RY12 KIF25 F3 F2RL2
2 11.49 SERPINC1 F3 F2RL2
3 10.77 SLX4 FANCI FANCA

GO Terms for Thrombophlebitis Migrans

Cellular components related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromosome, telomeric region GO:0000784 9.33 XRCC1 SLX4 PINX1
2 chromosome, telomeric region GO:0000781 9.13 SLX4 SIRT2 PINX1
3 ERCC4-ERCC1 complex GO:0070522 8.62 XRCC1 SLX4

Biological processes related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.72 XRCC1 SLX4 FANCI FANCA CHD1L
2 blood coagulation GO:0007596 9.56 SERPINC1 P2RY12 F3 F2RL2
3 negative regulation of telomere maintenance via telomere lengthening GO:1904357 9.37 SLX4 PINX1
4 DNA repair GO:0006281 9.35 XRCC1 SLX4 FANCI FANCA CHD1L
5 interstrand cross-link repair GO:0036297 9.33 SLX4 FANCI FANCA
6 hemostasis GO:0007599 8.92 SERPINC1 P2RY12 F3 F2RL2

Molecular functions related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.8 SERPINC1 POLG F3

Sources for Thrombophlebitis Migrans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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