MCID: THR007
MIFTS: 29

Thrombophlebitis Migrans

Categories: Blood diseases, Cardiovascular diseases

Aliases & Classifications for Thrombophlebitis Migrans

MalaCards integrated aliases for Thrombophlebitis Migrans:

Name: Thrombophlebitis Migrans 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:14392
ICD9CM 34 453.1
SNOMED-CT 67 31268005
ICD10 32 I82.1
UMLS 71 C0152250

Summaries for Thrombophlebitis Migrans

Disease Ontology : 12 A thrombophlebitis that is characterized by repeated occurances of thrombophlebitis in different locations.

MalaCards based summary : Thrombophlebitis Migrans is related to thrombophlebitis and buerger disease. An important gene associated with Thrombophlebitis Migrans is POU4F3 (POU Class 4 Homeobox 3), and among its related pathways/superpathways is Direct p53 effectors. Affiliated tissues include lymph node, lung and pancreas, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Thrombophlebitis Migrans

Diseases related to Thrombophlebitis Migrans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 29)
# Related Disease Score Top Affiliating Genes
1 thrombophlebitis 11.9
2 buerger disease 10.3
3 colitis 10.3
4 ulcerative colitis 10.3
5 adenocarcinoma 10.2
6 pancreatic adenocarcinoma 10.2
7 cryofibrinogenemia, familial primary 10.1
8 sarcoidosis 1 10.1
9 thrombophilia due to thrombin defect 10.1
10 varicose veins 10.1
11 budd-chiari syndrome 10.1
12 myelodysplastic syndrome 10.1
13 erysipeloid 10.1
14 exanthem 10.1
15 purpura fulminans 10.1
16 thrombosis 10.1
17 leukemia 10.1
18 acute cystitis 10.1
19 vascular disease 10.1
20 papillary carcinoma 10.1
21 purpura 10.1
22 pancreatitis 10.1
23 vasculitis 10.1
24 pulmonary embolism 10.1
25 polyarteritis nodosa 10.1
26 cutaneous polyarteritis nodosa 10.1
27 ischemic neuropathy 9.7 POU4F2 POU4F1
28 optic nerve hypoplasia, bilateral 9.7 POU4F2 POU4F1
29 optic nerve disease 9.5 POU4F2 POU4F1

Comorbidity relations with Thrombophlebitis Migrans via Phenotypic Disease Network (PDN):


Deficiency Anemia

Graphical network of the top 20 diseases related to Thrombophlebitis Migrans:



Diseases related to Thrombophlebitis Migrans

Symptoms & Phenotypes for Thrombophlebitis Migrans

GenomeRNAi Phenotypes related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.53 KLRC2
2 Increased shRNA abundance (Z-score > 2) GR00366-A-116 9.53 KLRC2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-145 9.53 KLRC2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.53 KLRC2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-151 9.53 POU4F3
6 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.53 KLRC2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-17 9.53 POU4F3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.53 KLRC2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-191 9.53 KLRC2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-195 9.53 POU4F3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-204 9.53 KLRC2
12 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.53 KLRC2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.53 KLRC2
14 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.53 POU4F3
15 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.53 POU4F3
16 Increased shRNA abundance (Z-score > 2) GR00366-A-96 9.53 POU4F3

MGI Mouse Phenotypes related to Thrombophlebitis Migrans:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.65 ESRRB F3 POU4F1 POU4F2 POU4F3
2 hearing/vestibular/ear MP:0005377 9.33 ESRRB POU4F2 POU4F3
3 normal MP:0002873 9.26 F3 POU4F1 POU4F2 POU4F3
4 vision/eye MP:0005391 8.92 F3 POU4F1 POU4F2 POU4F3

Drugs & Therapeutics for Thrombophlebitis Migrans

Search Clinical Trials , NIH Clinical Center for Thrombophlebitis Migrans

Genetic Tests for Thrombophlebitis Migrans

Anatomical Context for Thrombophlebitis Migrans

MalaCards organs/tissues related to Thrombophlebitis Migrans:

40
Lymph Node, Lung, Pancreas, Liver, Prostate

Publications for Thrombophlebitis Migrans

Articles related to Thrombophlebitis Migrans:

(show top 50) (show all 89)
# Title Authors PMID Year
1
Thrombophlebitis Migrans. 61
32181733 2020
2
Thrombophlebitis Migrans (Trousseau Syndrome) in Pancreatic Adenocarcinoma: An Autopsy Report. 61
31687303 2019
3
[Paraneoplastic syndromes]. 61
31283129 2019
4
Thrombophlebitis migrans in a man with pancreatic adenocarcinoma: a case report. 61
19829832 2009
5
[Superficial migratory thrombophlebitis: a clinical and histologic review of 8 cases]. 61
18501171 2008
6
Thrombophlebitis migrans as a footprint of Buerger's disease: a prospective-descriptive study in north-east of Iran. 61
17554578 2008
7
[Conservative management of thrombophlebitis. Cooling, wrapping and mobilizing the patient]. 61
12380352 2002
8
Low-molecular-weight heparin in the management of Trousseau's syndrome. 61
9264346 1997
9
Thrombophlebitis migrans in association with acute relapsing pancreatitis. 61
7613951 1995
10
[Thrombophlebitis migrans as the first symptom of a myelodysplastic syndrome]. 61
8271871 1993
11
[Thromboangiitis obliterans associated with small-vessel vasculitis]. 61
2622287 1989
12
Trousseau's syndrome caused by malignant degeneration of a choledochal cyst. 61
2552588 1989
13
Thrombophlebitis migrans following co-trimoxazole therapy. 61
2789377 1989
14
[A clinical case of thrombophlebitis migrans]. 61
3222318 1988
15
[Recurrent cerebral emboli in nonbacterial thrombotic endocarditis]. 61
3678075 1987
16
Thrombophlebitis migrans as a marker of malignancy. 61
3792254 1986
17
Clinical investigations on long-term activation of fibrinolysis by anabolic steroids. 61
2427405 1986
18
Cryoproteins. 61
3767197 1986
19
Occult cancer in patients with acute pulmonary embolism. 61
7073147 1982
20
[Isolated visceral thrombophlebitis migrans]. 61
7040283 1982
21
Thrombophlebitis migrans in association with ulcerative colitis. 61
7310913 1981
22
[Observation of a case of combined gastric carcinoma and thrombophlebitis migrans of the deep veins of the legs]. 61
7253489 1981
23
Thrombophlebitis migrans: a further systemic complication of ulcerative colitis. 61
7393815 1980
24
Carcinoma of the prostate presenting as thrombophlebitis migrans. 61
441875 1979
25
Prophylaxis of recurrent venous thrombosis with long-term enhancement of fibrinolysis. 61
94894 1979
26
Thrombophlebitis migrans in ulcerative colitis. 61
604994 1977
27
Recurrent venous thrombosis (thrombophlebitis migrans) and carcinoma of the lung. 61
887028 1977
28
[Thrombophlebitis migrans]. 61
905331 1977
29
Thrombophlebitis migrans. An unusual presentation as a collagen vascular disease--report of a case. 61
4147715 1973
30
[Behavior of thrombocytes under immunosuppressive and anticoagulant therapy in a case of thrombophlebitis migrans]. 61
4637708 1972
31
[Thrombophlebitis migrans and secondary papillary carcinoma of the lung]. 61
5119038 1971
32
[Determination of circulating auto-antibodies against fibrinogen in thrombophlebitis migrans]. 61
5485822 1970
33
Budd-Chiari syndrome caused by a web as a result of visceral thrombophlebitis migrans. Report of a case. 61
5439474 1970
34
[Thrombophlebitis migrans--an early mask of a neoplasm]. 61
5697951 1968
35
[Purpura fulminans in the pathological anatomical picture of a case of thrombophlebitis migrans et saltans]. 61
5640354 1968
36
Thrombophlebitis migrans associated with circulating antibodies against Fibrinogen. A case report. 61
4173215 1967
37
[NOSOLOGIC AND PATHOGENIC CONSIDERATIONS ON THROMBOPHLEBITIS MIGRANS. DESCRIPTION OF 2 CASES CORRELATED WITH DIAPHRAGMATIC HERNIA]. 61
14336340 1965
38
[Acute hemocytoblastic leukemia with unusual initial clinical picture: thrombophlebitis migrans]. 61
14461800 1962
39
[A case of periarteritis nodosa with thrombophlebitis migrans of the lower extremity]. 61
13981000 1962
40
[Thrombophlebitis migrans. Critical review and clinical contribution]. 61
13891256 1961
41
[Long-term treatment of thrombophlebitis migrans with phenylbutazone (Butazolidin, Geigy)]. 61
13712690 1961
42
A case of thrombophlebitis migrans. 61
13705312 1961
43
[Thrombophlebitis migrans and its pathogenetic relations to thromboangiitis obliterans]. 61
13736029 1961
44
Refractory thrombophlebitis migrans in malignant disease. 61
13840068 1960
45
[A compression syndrome of the inferior vena cava as a rare localization of thrombophlebitis migrans]. 61
13853821 1960
46
[On the pathogenesis of thrombophlebitis migrans in carcinoma]. 61
14407321 1960
47
[Clinical observations on thrombophlebitis migrans, with a case contribution]. 61
14443876 1960
48
[Association of Besnier-Boeck-Schaumann sarcoidosis with thrombophlebitis migrans. Description of a case]. 61
14431079 1959
49
[Arteriolitis. Thrombophlebitis migrans. Benign insular gangrene. Mutilating acropathy and rickettsiosis. Neo-rickettsiosis]. 61
14438530 1959
50
[Thrombophlebitis migrans of superficial veins during thromboangiitis obliterans]. 61
13601346 1958

Variations for Thrombophlebitis Migrans

Expression for Thrombophlebitis Migrans

Search GEO for disease gene expression data for Thrombophlebitis Migrans.

Pathways for Thrombophlebitis Migrans

Pathways related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.74 POU4F2 POU4F1

GO Terms for Thrombophlebitis Migrans

Cellular components related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear chromatin GO:0000790 8.92 POU4F3 POU4F2 POU4F1 ESRRB

Biological processes related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 9.81 POU4F3 POU4F2 POU4F1 ESRRB
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.76 POU4F3 POU4F2 POU4F1 ESRRB
3 neuron differentiation GO:0030182 9.56 POU4F2 POU4F1
4 sensory perception of sound GO:0007605 9.55 POU4F3 POU4F2
5 regulation of signal transduction by p53 class mediator GO:1901796 9.54 POU4F2 POU4F1
6 axonogenesis GO:0007409 9.52 POU4F2 POU4F1
7 cellular response to cytokine stimulus GO:0071345 9.49 POU4F2 POU4F1
8 inner ear development GO:0048839 9.48 POU4F3 ESRRB
9 neuromuscular process controlling balance GO:0050885 9.43 POU4F3 POU4F2
10 cellular response to estradiol stimulus GO:0071392 9.4 POU4F2 POU4F1
11 regulation of DNA-binding transcription factor activity GO:0051090 9.37 POU4F2 POU4F1
12 axon extension GO:0048675 9.32 POU4F3 POU4F2
13 intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 9.26 POU4F2 POU4F1
14 positive regulation of osteoclast differentiation GO:0045672 9.16 POU4F2 POU4F1
15 retinal ganglion cell axon guidance GO:0031290 8.96 POU4F3 POU4F2
16 positive regulation of transcription regulatory region DNA binding GO:2000679 8.62 POU4F2 POU4F1

Molecular functions related to Thrombophlebitis Migrans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.62 POU4F3 POU4F2 POU4F1 ESRRB
2 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.56 POU4F3 POU4F2 POU4F1 ESRRB
3 sequence-specific DNA binding GO:0043565 9.46 POU4F3 POU4F2 POU4F1 ESRRB
4 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.26 POU4F3 POU4F2 POU4F1 ESRRB
5 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.92 POU4F3 POU4F2 POU4F1 ESRRB

Sources for Thrombophlebitis Migrans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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