Thrombosis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: THR024 MIFTS: 54	Thrombosis Categories: Blood diseases, Cardiovascular diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Thrombosis

MalaCards integrated aliases for Thrombosis:

IMPROVED

Name: Thrombosis ¹¹ ⁵³ ⁴³ ¹⁴ ⁷¹

Thrombosis of Blood Vessel ⁷¹

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060903

MeSH ⁴³ D013927

UMLS ⁷¹ C0040053 C2586211

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Summaries for Thrombosis

Disease Ontology: ¹¹ A vascular disease caused by the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system.

MalaCards based summary: Thrombosis, also known as thrombosis of blood vessel, is related to thrombophilia due to thrombin defect and cavernous sinus thrombosis. An important gene associated with Thrombosis is F2 (Coagulation Factor II, Thrombin), and among its related pathways/superpathways are Metabolism of proteins and Signal Transduction. The drugs Dabigatran and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and heart, and related phenotypes are no effect and no effect

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Related Diseases for Thrombosis

Diseases related to Thrombosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2507)

#	Related Disease	Score	Top Affiliating Genes
1	thrombophilia due to thrombin defect	33.2	VWF THBD SERPINC1 PROC PLAT FGA
2	cavernous sinus thrombosis	33.1	SERPINC1 F3 F2
3	portal vein thrombosis	33.1	VWF THBD SERPINC1 PLG JAK2 F5
4	coronary thrombosis	33.0	VWF SERPINC1 PLG PLAT GP1BA FGA
5	intracranial thrombosis	32.9	VWF SERPINC1 PLG PLAT FGA F5
6	sagittal sinus thrombosis	32.8	SERPINC1 PLG JAK2 F5 F3 F2
7	lateral sinus thrombosis	32.8	SERPINC1 F2
8	heparin-induced thrombocytopenia	32.7	F3 F2
9	carotid artery thrombosis	32.7	VWF SERPINC1 PLG PLAT GP1BA F3
10	budd-chiari syndrome	32.7	VWF SERPINC1 PLG JAK2 FGB F5
11	essential thrombocythemia	32.6	VWF THBD PLAT JAK2 GP1BA
12	intracranial sinus thrombosis	32.5	SERPINC1 PLG F3 F2 APOH
13	antiphospholipid syndrome	32.5	VWF THBD TFPI SERPINC1 PLAT GP1BA
14	antithrombin iii deficiency	32.5	SERPINC1 PLG JAK2 FGA F5 F3
15	cerebral sinovenous thrombosis	32.5	F5 F2
16	pulmonary embolism	32.5	VWF THBD SERPINC1 PROS1 PROC PLAT
17	thrombophilia due to activated protein c resistance	32.4	VWF THBD SERPINC1 PLG F9 F5
18	protein s deficiency	32.4	THBD SERPINC1 PROS1 PROC FGA F5
19	buerger disease	32.4	SERPINC1 F2 APOH
20	post-thrombotic syndrome	32.4	VWF THBD TFPI SERPINC1 PLG PLAT
21	protein c deficiency	32.4	THBD SERPINC1 PROC F9 F5 F2
22	vascular disease	32.3	VWF THBD SERPINC1 PLAT GP1BA FGB
23	polycythemia vera	32.3	VWF THBD SERPINC1 JAK2 GP1BA F5
24	dysfibrinogenemia, congenital	32.3	THBD SERPINC1 PLAT FGG FGB FGA
25	shwartzman phenomenon	32.3	SERPINA10 F3
26	coumarin resistance	32.3	PROS1 F9 F2
27	hyperhomocysteinemia	32.2	VWF THBD SERPINC1 PLAT F5 F2
28	homocysteinemia	32.2	F5 F2
29	thrombophilia	32.1	VWF THBD TFPI SERPINC1 SERPINA10 PROS1
30	hepatic veno-occlusive disease	32.1	THBD SERPINC1 PLG PLAT F3
31	chronic venous insufficiency	32.1	VWF SERPINC1 PLG F3 F2
32	factor vii deficiency	32.1	SERPINC1 F9 F3 F2
33	moyamoya disease 1	32.1	VWF SERPINC1 PLG PLAT F3 F2
34	varicose veins	32.0	VWF THBD SERPINC1 PLAT F5 F2
35	factor v deficiency	32.0	VWF SERPINC1 F9 F5 F3 F2
36	vitamin k deficiency bleeding	32.0	SERPINC1 PROS1 F9 F3 F2
37	central retinal vein occlusion	32.0	SERPINC1 PLG PLAT F5 F3 F2
38	cardiovascular system disease	31.9	VWF THBD SERPINC1 PLG PLAT FGA
39	systemic lupus erythematosus	31.9	VWF THBD SERPINC1 PLG F3 F2
40	livedoid vasculitis	31.9	SERPINC1 PLG F3 F2 APOH
41	polycythemia	31.8	JAK2 F5 F3 F2
42	factor viii deficiency	31.8	VWF TFPI SERPINC1 F9 F5 F3
43	nephrotic syndrome	31.8	SERPINC1 PLG FGA F9 F3 F2
44	heparin cofactor ii deficiency	31.7	SERPINC1 PLG
45	thrombocytopenia	31.7	VWF THBD SERPINC1 PROS1 PROC PLAT
46	behcet syndrome	31.7	VWF THBD SERPINC1 JAK2 F5 F3
47	venous insufficiency	31.7	VWF PLAT F5 F2
48	stroke, ischemic	31.7	VWF THBD SERPINC1 PLG PLAT GP1BA
49	thrombophlebitis	31.7	VWF SERPINC1 PROS1 PROC PLG PLAT
50	intracranial hypertension	31.7	SERPINC1 PLG F9 F5 F3 F2

Graphical network of the top 20 diseases related to Thrombosis:

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Symptoms & Phenotypes for Thrombosis

GenomeRNAi Phenotypes related to Thrombosis according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.18	APOH F13A1 F2 F3 F5 F9
2	no effect	GR00402-S-2	10.18	APOH F13A1 F2 F3 F5 F9

MGI Mouse Phenotypes related to Thrombosis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.43	APOH F13A1 F2 F3 F5 F9
2	nervous system	MP:0003631	10.32	F2 F3 F5 FGA JAK2 PLAT
3	cardiovascular system	MP:0005385	10.32	F13A1 F2 F3 F5 F9 FGA
4	immune system	MP:0005387	10.13	F2 F3 F9 FGA FGG JAK2
5	liver/biliary system	MP:0005370	10.11	F5 F9 FGA JAK2 PLG PROC
6	embryo	MP:0005380	10.1	F2 F3 F5 F9 FGA FGG
7	hematopoietic system	MP:0005397	10.06	F13A1 F2 F3 F9 FGA FGB
8	mortality/aging	MP:0010768	9.93	APOH F13A1 F2 F3 F5 F9
9	respiratory system	MP:0005388	9.91	F13A1 F2 F3 FGG JAK2 PLAT
10	integument	MP:0010771	9.36	F13A1 F2 F3 F5 FGA JAK2

Sources

Drugs & Therapeutics for Thrombosis

Drugs for Thrombosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 375)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Dabigatran

Approved, Investigational

Phase 4

211914-51-1

216210

Norethisterone

Approved

Phase 4

68-22-4

199472 6230

Acenocoumarol

Approved, Investigational

Phase 4

152-72-7

54676537 9052

Dydrogesterone

Approved, Investigational, Withdrawn

Phase 4

152-62-5

9051

Tranylcypromine

Approved, Investigational

Phase 4

155-09-9

5530 441233

Alprostadil

Approved, Investigational

Phase 4

745-65-3

5280723

Abciximab

Approved

Phase 4

143653-53-6

3815015

Estradiol

Approved, Investigational, Vet_approved

Phase 4

50-28-2

5757

Polyestradiol phosphate

Approved

Phase 4

28014-46-2

Everolimus

Approved

Phase 4

159351-69-6

70789204 6442177

Fluindione

Approved, Investigational

Phase 4

957-56-2

Phenindione

Approved, Investigational

Phase 4

83-12-5

4760

Acetaminophen

Approved

Phase 4

103-90-2

1983

Clavulanic acid

Approved, Vet_approved

Phase 4

58001-44-8

5280980

Orange

Approved

Phase 4

Liraglutide

Approved

Phase 4

204656-20-2

44147092 16134956

Taurolidine

Approved, Investigational

Phase 4

19388-87-5

Glimepiride

Approved

Phase 4

93479-97-1

3476

Metformin

Approved

Phase 4

1115-70-4, 657-24-9

4091

Vildagliptin

Approved, Investigational

Phase 4

274901-16-5

6918537

Progesterone

Approved, Vet_approved

Phase 4

57-83-0

5994

Racepinephrine

Approved, Vet_approved

Phase 4

51-43-4, 329-65-7

838 5816

Acetylcholine

Approved, Investigational

Phase 4

51-84-3

187

Warfarin

Approved

Phase 4

81-81-2, 129-06-6

54678486

Ticagrelor

Approved

Phase 4

274693-27-5

9871419

Dipyridamole

Approved

Phase 4

58-32-2

3108

Pancrelipase

Approved, Investigational

Phase 4

53608-75-6

8519

Dronedarone

Approved

Phase 4

141626-36-0

208898

Erythromycin

Approved, Investigational, Vet_approved

Phase 4

55-31-2, 114-07-8

12560

Glucosamine

Approved, Investigational

Phase 4

3416-24-8

318324 439213

Ketoconazole

Approved, Investigational

Phase 4

65277-42-1, 142128-57-2

47576 3823 638701

Sorafenib

Approved, Investigational

Phase 4

284461-73-0

216239

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Cathine

Approved, Experimental, Illicit, Vet_approved, Withdrawn

Phase 4

14838-15-4, 492-39-7

131954576 4786 26934

Apixaban

Approved

Phase 4

503612-47-3

10182969

Reviparin

Approved, Investigational

Phase 4

9041-08-1

Rivaroxaban

Approved

Phase 4

366789-02-8

9875401

Plasminogen

Approved

Phase 4

9001-91-6

Clopidogrel

Approved

Phase 4

120202-66-6, 113665-84-2

60606

Fondaparinux

Approved, Investigational

Phase 4

114870-03-0, 104993-28-4

5282448 636380

Desirudin

Approved

Phase 4

120993-53-5

16129703

Argatroban

Approved, Investigational

Phase 4

74863-84-6

152951 92722

Garlic

Approved, Nutraceutical

Phase 4

8008-99-9

Batroxobin

Experimental

Phase 4

9039-61-6

Coumarin

Experimental

Phase 4

91-64-5

323

Arachidonic Acid

Experimental

Phase 4

506-32-1

444899

Chlorotrianisene

Investigational, Withdrawn

Phase 4

569-57-3

11289

Norethindrone Acetate

Phase 4

541197

Vasodilator Agents

Phase 4

Anesthetics

Phase 4

Interventional clinical trials:

(show top 50) (show all 1380)

#	Name	Status	NCT ID	Phase	Drugs
1	Residual Vein Thrombosis Establishes the Optimal Duration of Low Molecular Weight Heparins in Cancer Patients With Deep Vein Thrombosis of the Lower Limbs	Unknown status	NCT00450645	Phase 4	low molecular weight heparin
2	Rosuvastatin for Prevention of Deep Vein Thrombosis in Patients Undergoing Total Knee Replacement Arthroplasty: STOP DVT - A Prospective Randomized Controlled Trial	Unknown status	NCT01021488	Phase 4	Rosuvastatin 20mg/d for 14days;enoxaparin only
3	Comparison of Ultra-low-dose Oral Versus Trans-dermal Hormone Therapy on Coagulation Activation and Metabolic Risk Factors for Cardiovascular Disease	Unknown status	NCT02264743	Phase 4	Femoston Conti;EVOREL® CONTI
4	Dose Effect of Tranexamic Acid on the Incidence of Deep Venous Thrombus in Cardiac Surgery With Cardiopulmonary Bypass	Unknown status	NCT03838328	Phase 4	Tranexamic Acid
5	Effect of Anticoagulation After Endoscopic Therapy in Cirrhotic Patients With Portal Vein Thrombosis：A Zelen-design Multicenter Randomized Controlled Trial	Unknown status	NCT02630095	Phase 4	Nadroparin Calcium and Warfarin
6	Two Weeks of Low Molecular Weight Heparin for Distal Vein Thrombosis (TWISTER)	Unknown status	NCT01252420	Phase 4	Enoxaparin
7	Reload of High Dose Atorvastatin for Preventing Deep Vein Thrombosis in Statin Users Undergoing Total Knee Replacement Arthroplasty: RE-STOP-DVT Study- A Prospective Randomized Controlled Trial	Unknown status	NCT01063426	Phase 4	High dose Atorvastatin+enoxaparin;Enoxaparin
8	The Efficacy and Safety of Batroxobin Combined With Anticoagulation in Cerebral Venous Sinus Thrombosis	Unknown status	NCT04269954	Phase 4	Batroxobin combined with low molecular weight heparin
9	The Efficacy and Safety of Prophylactic Anticoagulation for Catheter-related Thrombosis in Patients With Cancer and Implantable Venous Access Ports: a Prospective Multi-center Randomized Controlled Trial.	Unknown status	NCT04256525	Phase 4	Rivaroxaban 10mg;Aspirin 100mg;low molecule heparin
10	Patient Adherence to Venous Thromboembolism Prophylaxis in Orthopaedic Trauma Patients: A Randomized, Controlled Trial Comparing Subcutaneous Enoxaparin & Oral Rivaroxaban	Unknown status	NCT04169269	Phase 4	Enoxaparin 40 milligram/0.4 milliliter Injectable Syringe 0.4 milliliters;Rivaroxaban 10 milligram Oral Tablet
11	Study of the OmniWave Endovascular System in Subjects With Lower and Upper Extremity Deep Vein Thrombosis - SONIC I Study	Unknown status	NCT00640731	Phase 4
12	Efficacy and Safety of Warfarin Anticoagulation for Prevention of Portal Vein Thrombosis in Liver Cirrhotic Patients With Hypersplenism After Laparoscopic Splenectomy	Unknown status	NCT02238444	Phase 4	Warfarin;Dipyridamole;Aspirin;Low Molecular Weight Heparin
13	Outcome of Percutaneous Mechanical Thrombectomy to Treat Acute Deep Venous Thrombosis	Unknown status	NCT02959801	Phase 4
14	A Zelen-design Randomized Controlled Trial of the Effect of Anticoagulation After Endoscopic Therapy in Cirrhotic Patients With Portal Vein Thrombosis	Unknown status	NCT02398357	Phase 4	Nadroparin Calcium and Warfarin
15	The Danish Non-vitamin K Antagonist Oral Anticoagulation Study. A Cluster Randomized Study Comparing Safety and Efficacy of Edoxaban, Apixaban, Rivaroxaban and Dabigatran for Oral Anticoagulation in Patients With Venous Thromboembolism.	Unknown status	NCT03129555	Phase 4	Dabigatran Etexilate Oral Capsule;Rivaroxaban Oral Tablet;Edoxaban Oral Tablet;Apixaban Oral Tablet
16	Single-blind, Randomized Comparison of Warfarin Management Guided by NextDose Versus Management Based on Clinician Experience.	Unknown status	NCT04510805	Phase 4
17	Applying Pharmacogenetics to Warfarin Dosing in Chinese Patients	Unknown status	NCT01610141	Phase 4
18	Apixaban for Prevention of Post-angioplasty Thrombosis of Hemodialysis Vascular Access	Unknown status	NCT04489849	Phase 4	Apixaban 2.5 MG
19	PPARGC1β And CNTN4 Genotype as a Pharmacogenetic Assay of Thrombosis and Bleeding Risks - a Cross-Over Controlled Trial of Aspirin in Individuals at Increased Cardiovascular Risk.	Unknown status	NCT02970604	Phase 4	Aspirin
20	anti10a Levels in Women Treated With LMWH in the Postpartum Period for Preventing Vein Thrombosis Events: A Comparison of Two Doses	Unknown status	NCT02856295	Phase 4	clexane (LMWH)
21	Low Molecular Weight Heparin in Prevention of Recurrent Arteriovenous Graft Thrombosis in Chronic Hemodialysis Patients.	Unknown status	NCT01970280	Phase 4	Enoxaparin
22	Rule Out Transcatheter Aortic Valve Thrombosis With Post Implantation Computed Tomography	Unknown status	NCT02826200	Phase 4	Acenocoumarol
23	Comparison of Topical and Infusion Tranexamic Acid on Blood Loss and Risk of Deep Vein Thrombosis After Total Knee Arthroplasty	Unknown status	NCT02453802	Phase 4	Tranexamic Acid 5%,5ml/amp;rivaroxaban (10mg);0.9% Normal Saline
24	RCT Research: the Treatment of Hepatic Carcinoma With Portal Vein Branch Tumor Thrombosis (Resection or Sorafenib)	Unknown status	NCT03178656	Phase 4	Sorafenib
25	Taurolidine Citrate and Unfractionated Heparin Combination Versus Unfractionated Heparin Alone in Prevention of Inflammation in Hemodialysis Catheters.	Unknown status	NCT03539718	Phase 4	Taurolidine heparin;Heparin Sodium
26	Phenprocoumon Versus Dabigatran in Subjects With Atrial Fibrillation and Left Atrial Thrombus - a Prospective, Randomized, Controlled, Open-label One Year Follow-up Pilot Study	Unknown status	NCT02591225	Phase 4	Dabigatranetexilate;Phenprocoumon
27	a Comparative Study of Aspirin Either at Fixed Dose or at a Dose Titrated by Platlet Function Analyzer(PFA-100) vs Placebo in Primary Prevention of Vascular Access for Hemodialysis	Unknown status	NCT02055131	Phase 4	aspirin
28	Evaluation of the Potential Action of Coagulation Factors Concentrates in the Reversal of the Antithrombotic Action of New Oral Anticoagulants: Studies ex Vivo in Blood Samples From Healthy Volunteers	Unknown status	NCT01478282	Phase 4	Rivaroxaban;Dabigatran
29	A Randomised Controlled Trial Comparing Bacteraemia Rates in Closed Luer Lock Access Devices(TEGO) With Standard Devices in the Outpatient Haemodialysis Population	Unknown status	NCT01082770	Phase 4
30	Impact of a Biological Glue (Evicel®) on the Peri Operative Bleeding in Total Knee Prothesis Surgery	Unknown status	NCT00983112	Phase 4	Human Fibrinogen and human thrombin (Evicel);Sodium Chlorure (Physiological saline)
31	A Multi-center Randomized Controlled Study of High/Low-dosage Rivaroxaban Compared With DAPT After Left Atrial Appendage Occulsion in Patients With Non-valvular Atrial Fibrillation（ESCORT-AF Study）	Unknown status	NCT04135677	Phase 4	Rivaroxaban;DAPT
32	Phase 4 Study of Postoperative Prostaglandin E1 in Head and Neck Microsurgery	Unknown status	NCT00733434	Phase 4	Prostaglandin E1
33	Bedside Testing of the CYP2C19 Gene to Asses Effectiveness of Clopidogrel in Coronary Artery Disease Patients Treated With Percutaneous Coronary Intervention : Individualized Antiplatelet Drugs Treatment to Improve Prognosis	Unknown status	NCT01823185	Phase 4	clopidogrel;Ticagrelor or prasugrel
34	Prolonged Hemodialysis Catheter Survival With Copolymer Coating and Rt-PA - PROCOPrt-PA Trial	Unknown status	NCT01670474	Phase 4	rt-PA (2mg/2mL) actilysis;rt-PA
35	Phase 4 Study of Primary Angioplasty Combined Distal Injection of Abciximab to Thrombus and Aspiration With Catheter	Unknown status	NCT01383785	Phase 4
36	Thrombus Aspiration During Percutaneous Coronary Intervention in Acute Non-ST-elevation Myocardial Infarction Study (TAPAS II)	Unknown status	NCT01013038	Phase 4
37	Hepatic Resection Versus Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Complicated by Portal Vein Tumor Thrombosis.A Prospective and Randomized Clinical Trial	Unknown status	NCT01350206	Phase 4
38	A Multi-center Study on the Optimized Antithrombotic Therapy of Acute Myocardial Infarction With Left Ventricular Mural Thrombus.	Unknown status	NCT03415386	Phase 4	Combination of antiplatelet drugs and anticoagulants for at least one month
39	Treatment of Upper Extremity Deep-Vein Thrombosis	Completed	NCT00245856	Phase 4	Dalteparin sodium injection;Warfarin
40	Absence of Residual Vein Thrombosis After an Episode of Unprovoked Deep Vein Thrombosis: Short-Term Anticoagulation is Safe.	Completed	NCT00623987	Phase 4	warfarin accordingly INR value
41	Residual Vein Thrombosis (RVT) Establishes the Optimal Duration of Oral Anticoagulants After a First Episode of Deep Vein Thrombosis of the Lower Limbs	Completed	NCT00438230	Phase 4	Warfarin
42	XIENCE V Everolimus Eluting Coronary Stent System (EECSS) China: Post-Approval Randomized Control Trial (RCT)	Completed	NCT01178268	Phase 4
43	A Randomized Trial of the Effect of Low-Molecular-Weight Heparin Versus Warfarin Sodium on the Mortality in the Long-Term Treatment of Proximal Deep Vein Thrombosis (Main LITE Study)	Completed	NCT00203580	Phase 4	Tinzaparin sodium
44	Effectiveness of Weight-adjusted Prophylactic Low Molecular Weight Heparin Doses Compared With Lower Fixed Prophylactic Doses to Prevent Venous Thromboembolism in COVID-2019. The Multicenter Randomized Controlled Open-label Trial COVI-DOSE	Completed	NCT04373707	Phase 4	Enoxaparin
45	Clinical Trial of Two Durations of Warfarin Therapy in the Treatment of Deep Vein Thrombosis and/or Pulmonary Embolism	Completed	NCT00365950	Phase 4	Duration of anticoagulation;Warfarin duration
46	Echo-Doppler Assessment of the Occurrence of Asymptomatic Deep Vein Thrombosis (DVT) in Orthopedic Replacement Surgery Under Enoxaparine (PRENOXA)	Completed	NCT01354704	Phase 4	Enoxaparin
47	LITE Study, Appendix A (HOME-LITE), Amendment 6	Completed	NCT00203658	Phase 4	Tinzaparin sodium
48	A Pilot Study in Cancer Patients With Central Venous Catheter Associated Deep Vein Thrombosis in the Upper Extremity Treated With Rivaroxaban (Catheter 2)	Completed	NCT01708850	Phase 4	Rivaroxaban
49	Evaluation of Late Clinical Events After Drug-eluting Versus Bare-metal Stents in Patients at Risk: BAsel Stent Kosten Effektivitäts Trial - PROspective Validation Examination Part II (BASKET-PROVE II)	Completed	NCT01166685	Phase 4
50	Prospective, Randomized, Double-blinded Trial of the Efficacy and Safety of Different Doses and Duration of Low Molecular Weight Heparin (Dalteparin) in Superficial Vein Thrombosis	Completed	NCT01245998	Phase 4	Dalteparin

Search NIH Clinical Center for Thrombosis

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Pentoxifylline

Cochrane evidence based reviews: thrombosis

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Genetic Tests for Thrombosis

Sources

Anatomical Context for Thrombosis

Organs/tissues related to Thrombosis:

MalaCards : Liver, Endothelial, Heart, Whole Blood, Brain, Neutrophil, Lung

Sources

Publications for Thrombosis

Articles related to Thrombosis:

(show top 50) (show all 31037)

#	Title	Authors	PMID	Year
1	Clinical experience with alteplase in the management of intracardiac and major cardiac vessels thrombosis in pediatrics: a case series. ⁵³ ⁶²	Al-Jazairi AS...Cherfan AJ	20427940	2010
2	Persistency of low levels of anticardiolipin and anti-beta2 glycoprotein1 in thrombosis. ⁵³ ⁶²	Amaral M...Delgado Alves J	20206880	2010
3	Risk of thrombosis and infections of central venous catheters and totally implanted access ports in patients treated for cancer. ⁵³ ⁶²	Beckers MM...Biesma DH	19640573	2010
4	Acute mesenteric and aortic thrombosis associated with antithrombin deficiency: a rare occurrence. ⁵³ ⁶²	Calcaterra D...De Natale RW	19932950	2010
5	Emerging roles of fibronectin in thrombosis. ⁵³ ⁶²	Maurer LM...Mosher DF	20116835	2010
6	Increased expression of tissue factor and protease-activated receptor-1 does not correlate with thrombosis in human lung adenocarcinoma. ⁵³ ⁶²	de Meis E...Monteiro RQ	20445954	2010
7	Role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis. ⁵³ ⁶²	Kowalska MA...Poncz M	20004006	2010
8	P2Y12 or P2Y1 inhibitors reduce platelet deposition in a microfluidic model of thrombosis while apyrase lacks efficacy under flow conditions. ⁵³ ⁶²	Maloney SF...Diamond SL	20473398	2010
9	The annexin A5-mediated pathogenic mechanism in the antiphospholipid syndrome: role in pregnancy losses and thrombosis. ⁵³ ⁶²	Rand JH...Taatjes DJ	20353989	2010
10	An approach to molecular imaging of atherosclerosis, thrombosis, and vascular inflammation using microparticles of iron oxide. ⁵³ ⁶²	McAteer MA...Choudhury RP	19883911	2010
11	Neuropilin-1 targeting photosensitization-induced early stages of thrombosis via tissue factor release. ⁵³ ⁶²	Bechet D...Barberi-Heyob M	20087632	2010
12	Low level of factor V is associated with development of deep-vein thrombosis in Japanese patients. ⁵³ ⁶²	Suehisa E...Hidaka Y	19497612	2010
13	Continuous intraarterial thrombolysis for early hepatic artery thrombosis following liver transplantation: case report. ⁵³ ⁶²	Singhal A...Kohli V	20034941	2010
14	Increased risk of recurrent thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation. ⁵³ ⁶²	De Stefano V...GIMEMA Chronic Myeloproliferative Neoplasms Working Party	19582452	2010
15	JAK2 mutation and thrombosis in the myeloproliferative neoplasms. ⁵³ ⁶²	Vannucchi AM	20425393	2010
16	Murine strain differences in hemostasis and thrombosis and tissue factor pathway inhibitor. ⁵³ ⁶²	White TA...Simari RD	19398123	2010
17	ABO blood groups and genetic risk factors for thrombosis in Croatian population. ⁵³ ⁶²	Jukic I...Balija M	20017223	2009
18	Thrombosis markers in hip versus knee arthroplasty: a pilot study. ⁵³ ⁶²	Reikeras O...Clementsen T	20065366	2009
19	Human platelets produced in nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice upon transplantation of human cord blood CD34(+) cells are functionally active in an ex vivo flow model of thrombosis. ⁵³ ⁶²	Salles II...Deckmyn H	19741191	2009
20	Time course of thrombosis and fibrinolysis in total knee arthroplasty with tourniquet application. Local versus systemic activations. ⁵³ ⁶²	Reikeras O...Clementsen T	19067121	2009
21	Prevalence of factor V leiden mutation in patients with thrombosis in Tunisia. ⁵³ ⁶²	Ajem A...Mehjoub T	20218141	2009
22	Study on the changes of thrombosis-associated factors in patients with coronary heart disease of turbidity-phlegm blocking syndrome. ⁵³ ⁶²	Wang YL...Sun HY	19802536	2009
23	Correlation between leukocytosis and thrombosis in Philadelphia-negative chronic myeloproliferative neoplasms. ⁵³ ⁶²	Caramazza D...Siragusa S	19214510	2009
24	Procarboxypeptidase U (TAFI) contributes to the risk of thrombosis in patients with hereditary thrombophilia. ⁵³ ⁶²	Heylen E...Hendriks D	19195685	2009
25	Shear-induced global thrombosis test of native blood: pivotal role of ADP allows monitoring of P2Y12 antagonist therapy. ⁵³ ⁶²	Saraf S...Gorog DA	19476973	2009
26	Prevalence of aspirin and clopidogrel resistance among patients with and without drug-eluting stent thrombosis. ⁵³ ⁶²	Pinto Slottow TL...Waksman R	19660606	2009
27	Bilateral cavo-ilio-femoral thrombosis in an adolescent with transient anti-phospholipid antibodies and factor V heterozygous mutation: a case report. ⁵³ ⁶²	Frontino G...Pozzobon G	19918549	2009
28	Assessing the coagulation factor levels, inherited thrombophilia, and ABO blood group on the risk for venous thrombosis among Brazilians. ⁵³ ⁶²	Teixeira Mello TB...Annichino-Bizzacchi JM	19398413	2009
29	Factor V Leiden and thrombosis in patients with systemic lupus erythematosus: a meta-analysis. ⁵³ ⁶²	Kaiser R...Criswell LA	19421222	2009
30	Locally applied recombinant plasmin results in effective thrombolysis in a porcine model of arteriovenous graft thrombosis. ⁵³ ⁶²	Hoefer IE...Rotmans JI	19481472	2009
31	Thr715Pro P-selectin polymorphism and P-selectin release in blood obtained from the bleeding time wounds in patients with deep-vein thrombosis. ⁵³ ⁶²	Undas A...Siudak Z	19106004	2009
32	Residual thrombosis on ultrasonography to guide the duration of anticoagulation in patients with deep venous thrombosis: a randomized trial. ⁵³ ⁶²	Prandoni P...AESOPUS Investigators	19414836	2009
33	Cytochrome P450 2C19 loss-of-function polymorphism and stent thrombosis following percutaneous coronary intervention. ⁵³ ⁶²	Sibbing D...von Beckerath N	19193675	2009
34	Markers of thrombosis and hemostasis in acute coronary syndromes: relationship to increased heart rate and reduced heart-rate variability. ⁵³ ⁶²	Hamaad A...MacFadyen RJ	19353696	2009
35	Autoantibodies to heat shock protein 60 promote thrombus formation in a murine model of arterial thrombosis. ⁵³ ⁶²	Dieude M...Rauch J	19192108	2009
36	Relation of cytochrome P450 2C19 loss-of-function polymorphism to occurrence of drug-eluting coronary stent thrombosis. ⁵³ ⁶²	Giusti B...Gensini GF	19268736	2009
37	The prevalence of factor V (G1691A), MTHFR (C677T) and PT (G20210A) gene mutations in arterial thrombosis. ⁵³ ⁶²	Ozmen F...Akar N	19353312	2009
38	Platelet turnover, coagulation factors, and soluble markers of platelet and endothelial activation in essential thrombocythemia: relationship with thrombosis occurrence and JAK2 V617F allele burden. ⁵³ ⁶²	Arellano-Rodrigo E...Cervantes F	19105233	2009
39	Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation. ⁵³ ⁶²	de Candia M...Altomare C	19193009	2009
40	Mechanisms of microvascular thrombosis in thrombotic thrombocytopenic purpura. ⁵³ ⁶²	Tsai HM	19180123	2009
41	Successful management of multiple permanent pacemaker complications--infection, 13 year old silent lead perforation and exteriorisation following failed percutaneous extraction, superior vena cava obstruction, tricuspid valve endocarditis, pulmonary embolism and prosthetic tricuspid valve thrombosis. ⁵³ ⁶²	Kaul P...Baig W	19239701	2009
42	Role of pulsatile perfusion with tissue plasminogen activator in deceased donor kidneys with extensive glomerular thrombosis. ⁵³ ⁶²	Nghiem DD...Sureshkumar KK	19249467	2009
43	Calumenin but not reticulocalbin forms a Ca2+-dependent complex with thrombospondin-1. A potential role in haemostasis and thrombosis. ⁵³ ⁶²	Hansen GA...Honore B	18688696	2009
44	JAK2 V617F-positive latent essential thrombocythemia and splanchnic vein thrombosis: the role of bone marrow biopsy for the diagnosis of myeloproliferative disease. ⁵³ ⁶²	Allegra A...Musolino C	19478480	2009
45	The 19-bp deletion of dihydrofolate reductase (DHFR), methylenetetrahydrofolate reductase (MTHFR) C677T, Factor V Leiden, prothrombin G20210A polymorphisms in cancer patients with and without thrombosis. ⁵³ ⁶²	Eroglu A...Akar N	18682947	2009
46	Increased soluble urokinase plasminogen activator receptor (suPAR) is associated with thrombosis and inhibition of plasmin generation in paroxysmal nocturnal hemoglobinuria (PNH) patients. ⁵³ ⁶²	Sloand EM...Young NS	18954937	2008
47	Mitogen-activated protein kinases in hemostasis and thrombosis. ⁵³ ⁶²	Adam F...Bryckaert M	18826389	2008
48	Antithrombin level and circuit thrombosis during hemofiltration after cardiopulmonary bypass. ⁵³ ⁶²	Lanquetot H...Macchi L	18575842	2008
49	Acute left atrial thrombosis during anticoagulant therapy in a patient with antithrombin deficiency. ⁵³ ⁶²	Santangeli P...Sestito A	19014009	2008
50	High plasma levels of soluble P-selectin are predictive of venous thromboembolism in cancer patients: results from the Vienna Cancer and Thrombosis Study (CATS). ⁵³ ⁶²	Ay C...Pabinger I	18539899	2008

Sources

Genes for Thrombosis

Genes related to Thrombosis (0 elite genes):

(show top 50) (show all 67)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	F2	Coagulation Factor II, Thrombin	Protein Coding	61.66	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries Pathways & Interactions (show sections)	10744139 10974339 16231514 (more) 17205928 10065893 19538716 10741896 8339409 10365747 10725983 9886317 1331349 8902761 11307818 12865818 16601831 19853891 9711957 15946213 15879633 15116258 15060226 11770279 11375285 10728020 10477778 9846471 10847418 10586206 8902778 15637132 15323133 12970118 11289500 11085290 9835442 15292065 12761462 11575827 11386104 11071624 9776213 9684813 9341161 7485103 18516702 17440049 16689762 16493484 15490419 15370721 15257018 14630828 15170396 9499673 9364981 9308745 19067121 19414836 18574041 14669613 11914651 10877652 10498586 9294322 8085039 1554796 2366564 2356405 19713246 14504098 12454577 12421139 11146461 8701407 17330543 17059428 15749677 8491874 8436743 18257465 17938765 17041380 16102458 15787345 14584752 8134728 20182349 20065366 17678713 17075190 16623037 16305681 16006096 8084108 20017223 14512389 12871361 11421234
2	SERPINC1	Serpin Family C Member 1	Protein Coding	50.69	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	12888870 8148939 18575842 (more) 9764672 12591924 1489375 12080632 8701400 10191894 9763552 15710578 12434119 12361208 17512574 8958391 8429723 18827975 15205587 15162900 2133253 1696577 9607121 20232702 11721729 9746774 19202708 16409467 10515862 8640401 2102934 10766996 7742536 2240857 8701622 19422445 19014009 2191430 1937369 1523607 8951806 10552948 10706899 11796716 2191783 19932950 18206177 16000134 15543318 15314703 12907439 12939144 12192310 11305719 16096931 10667107 9759614 9205675 8979136 8921576 7620085 7835714 15353322 15338392 15198878 13677267 11030524 10898281 10838734 9868323 7959362 7590506 7627635 8184728 8350512 1489896 1570981 1782482 1530443 18727651 18004620 17607884 16871082 16444323 16392896 8397574 8443391 1718494 19931780 16493609 16439146 16417248 16689758 9164807 9396341 9241707 9198248 8873713 8751097 7900086
3	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	47.16	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	8657763 7692999 11387618 (more) 11719681 1732372 11844282 16961279 15105207 20427940 12166043 16171602 19249467 11237979 9814003 9587554 16193693 7834038 16273765 7942523 15781388 15985456 18945966 16143058 2119465 1400080 1452521 7952425 7843690 7738206 8735626 9170584 11774106 11307802 10422507 8869898 7740487 8217070 1455397 1796391 20034941 18187214 12815179 12421144 11494394 11483188 10792298 10367084 9776340 7495079 8322122 1899582 1697374 2111050 19481472 17593394 17463331 16175440 15102005 11138573 9669258 8819256 12949321 12612392 11757061 8026029 8249231 2122542 19239701 19375608 1641820 2129142 19260122 18005145 11060830 9798983 7967437 8042618 9127616 8344979 8341396 2123154 2107957 19605778 18323493 14630788 12759624 19404035 17959703 16953275 15830291 15487882 12439142 11948891 10429451 9607117 9385934 9269770 7664419 9627033
4	THBD	Thrombomodulin	Protein Coding	47.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Functions (show sections)	10685802 1651429 10460600 (more) 7737745 11518727 7942778 11966476 1325211 18444940 10971021 1661291 9071818 7669668 7878635 15235749 15389121 15085467 12831462 8073391 7522520 19333555 17049585 12818729 12421141 11094038 1333100 19055859 16398653 12871287 19105233 17677000 16126727 15351842 11812405 9391719 9054661 8869014 1846762 18000794 9684797 9294322 8626546 12522115 8163684 1325678 1648351 2170704 20102751 18590927 12707536 12871544 10690304 2291381 9551978 11231927 8902761 7855794
5	PROC	Protein C, Inactivator Of Coagulation Factors Va And VIIIa	Protein Coding	43.61	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Summaries (show sections)	10639721 9817680 17677000
6	F5	Coagulation Factor V	Protein Coding	39.66	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	12180730 8592550 8774498 (more) 9922996 19105233 8671856 9457968 8735145 9375883 9764672 19918549 9327760 7607278 9746774 9597197 9307261 9054652 8560406 19497612 11486902 9493571 9372020 11037865 10090167 9149031 8701400 15003896 11952004 11529632 8902987 11305719 9125617 9293873 10853194 11876968 11998221 19640573 18206439 11342806 11082430 10726007 8958391 7780138 7888671 7968118 12393556 10192659 9386668 9009443 8990627 19538716 18334899 10774459 8073406 11685046 10666427 9423813 9350638 19291653 17582472 16758522 11582938 10726047 10235428 9517770 7734374 16250317 11694407 19421222 12627662 12454577 11776051 11110695 10912662 10501988 9763348 9753484 8603019 20218141 18373789 16549134 15479893 9157576 8813095 8745708 7500751 9716630 9241708 8956934 17911197 11343382 2145968 8289554 7872247 9012145 9093595 9167020 10726026 10643310
7	APOH	Apolipoprotein H	Protein Coding	38.95	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	12393574 1497015 1418145 (more) 8170264 7781279 16444460 11697705 1782567 7950946 8362374 9132335 8059230 1452512 17895304 9733455 7778571 8369806 17895508 17534796 10225244 9893142 9868323 8547978 15065611 1505109 16830882 12605313 8977809 8607123 16378283 8363683 16425575 12764350 9292792 17549297 2385560 2239276 7951306 8539223 9073013 9542329 9857282 16004169 15760329 15219190 14644075 12428085 12322801 11876968 10461484 10229659 10404770 9268241 8611459 8549201 7620085 7779940 7744629 7731286 1471893 18360325 18303659 16765713 16236386 16129206 15946213 15825571 15507287 15168653 20206880 20353983 2111722 18267921 16079164 16354891 15936458 15946204 14679358 2114327 2315886 12892395 11092466 10443963 9921802 9814685 9583454 9147943 7485132 8547096 7661181 7648351 7873391 8308787 7686561 1345458 2303593 14694390 12816875 12876633
8	PLG	Plasminogen	Protein Coding	38.94	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)	8727351 17646899 9684804
9	FGB	Fibrinogen Beta Chain	Protein Coding	34.49	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)
10	FGG	Fibrinogen Gamma Chain	Protein Coding	34.09	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications Pathways & Interactions (show sections)
11	JAK2	Janus Kinase 2	Protein Coding	33.86	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	17296594 17412890 18796251 (more) 20425393 18394555 18632151 15858187 19214510 18336541 17703302 20104275 19105233 17110452 17885079 18385755 19582452 16977569 16461300 18616871 17439832 19478480 16673274
12	FGA	Fibrinogen Alpha Chain	Protein Coding	33.72	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	1295502 8348763 7554626 (more) 1433937 1290164 8147564 1894862 2394005 7485081 1835678
13	F9	Coagulation Factor IX	Protein Coding	33.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	7974341 12406910 15060420 (more) 9487334 10102478 12487836 15743006 15567468 11307831 18841277 16011597 15379713 9351535 11736930 18304911 1562731 19398413 15199517 15743915 10845896
14	GP1BA	Glycoprotein Ib Platelet Subunit Alpha	Protein Coding	32.74	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	12617110 19181367 19726719 (more) 12183630 14639140 18084279
15	PROS1	Protein S	Protein Coding	30.64	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	10706858 10607700 11297755 (more) 10790208 11776305 18433462
16	F3	Coagulation Factor III, Tissue Factor	Protein Coding	30.36	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8911269 16466951 18610631 (more) 17694958 11128671 20445954 15333031 20212456 9493575 18691506 15389118 19105233 10744152 19515372 15311157 10725976 15617024 10613637 1822600 8432863 7646254 10381897 10929045 11555704 15507269 18029910 17261530 17111362 16507316 16968331 16217771 16026816 16105945 15735028 12230918 11157486 10996336 10712418 10520779 10605785 9365093 8028193 8329706 9198248 9014551 8701413 8073391 19485900 20303064 19093728 17637264 18303139 20224254 2111722 19738116 19443933 17895508 18023707 18033956 17337288 16634370 15059609 14584752 12945880 12351386 11434567 11342462 11239792 10925314 10725743 15865421 15795326 15213027 10684811 9449688 9353321 9081693 8016816 1909518 1909397 20103969 15751817 12960603 12892395 12504401 12211410 11127477 10436545 9684064 17894019 17166244 17082321 16965389 16409465 16038715 14610342 12514112 1346817 19398123
17	F13A1	Coagulation Factor XIII A Chain	Protein Coding	29.65	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Pathways & Interactions (show sections)	15210587 9885364 9892598 (more) 11841441
18	TFPI	Tissue Factor Pathway Inhibitor	Protein Coding	29.37	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Functions (show sections)	11950688 18590936 9252393
19	SERPINA10	Serpin Family A Member 10	Protein Coding	29.24	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries (show sections)	11487045 18344422 16527896 (more) 15461625
20	VWF	Von Willebrand Factor	Protein Coding	28.48	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7823669 8490173 11380453 (more) 15870546 17059421 19275573 9805643 17719316 20416208 19105233 15606555 8767102 15735796 15660508 1490199 9093766 9205537 10819702 16862523 18945966 12165284 11472438 11418460 9459348 8541159 7819071 19349964 19498171 19318682 11843285 10800169 9885217 1287886 19180123 19085767 15026873 14631548 14521605 18272039 17243265 17146059 15735532 12172456 11722428 11297756 11007670 9306127 15941906 15922776 15662616 15534270 14872251 11332762 11019962 10544923 1893064 19726719 18927433 19069166 17493665 16270633 20075158 19802536 19192108 18187214 18263586 18156712 16416741 16320349 8428224 15662611 15213843 15157333 12513717 10037692 9690808 2102619 18544592 7811156 18295937 17635702 17083505 16332977 16543961 15364808 11986216 12960603 12618268 12439142 8770359 20409490 20081060 19353696 12871266 16420561 16774914 16102036 11487006 10886197
21	SERPINE1	Serpin Family E Member 1	Protein Coding	28.29	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8379599 9631870 17896948 (more) 15820196 9129629 1618111 12353306 16931622 8993938 1728462 8713790 10751199 11450024 11796716 15242559 15716278 20048208 15777535 14651143 12412817 12028454 10872824 7738206 8052438 8029817 8501542 11814516 11924038 10806569 10676714 10981064 9607117 9269770 8866409 8548430 11152905 10684811 9215280 9048903 8052957 8217070 16675897 16210992 16175011 12945879 12421149 12152654 11709802 11523251 10213868 9885437 9258409 7992252 17985503 17240171 16839355 15490419 15206145 12856128 12762974 12644882 11874941 17578681 16502012 11494394 10762292 10365747 10218712 10577569 9776340 9127616 16963535 7959356 1991382 7956624 19132220 18050673 15283042 12403669 11858480 16052298 15978095 15530472 15085467 14678868 14515194 12808446 12439142 8237997 1663280 2070877 20079523 19824427 17167506 16363254 16102055 8194088 15978107 15314703
22	SELP	Selectin P	Protein Coding	27.84	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15217633 15004723 19840484 (more) 7543539 11157679 12529770 12525501 19349964 16293978 19353696 7539623 17510305 16332977 15059609 11907492 1279433 18797697 12945872 12892395 9237020 16648968 14872251 10891447 9787764 19948214 14987915 19691482 19192108 15674735 19965629 19741191 19105233 18539899 17714064 12783114 14628421 15860378 15351841 12714834 11487009 19106004 15543321 11994565 11874941 11094038 10925332 19198705 16411399 11916067 19883911 17408109 15831808 10544909 10833791 11044418 11739312
23	F10	Coagulation Factor X	Protein Coding	27.62	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10604970 11554940 12829728 (more) 15338955 8983124 8017790 7634464 11170646 16156684 19355876 7688991 17413757 11886813 11737851 9438022 8016816 1730676 19193009 16316651 11434677 10980906 16923021 14597584 14582456 10807757 8267061 19423547 15617024 15668516 14872418 17334518 16146714 15102016 11562339 11087565 8869014 16959679 8786532 17114499 11150738 10425086 9092408 7641380 8388357 19155517 19256345 16730984 11434701 19117960 17576867 15781388 11172669 11177336 8578544
24	PF4	Platelet Factor 4	Protein Coding	27.39	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	14764524 20004006 9002937 (more) 8282825 12172457 10381515 9446652 15304392 9067497 20206875 9372019 11966476 17257993 12244485 8252943 19249435 16855347 15282658 8833886 1835678 19379430 16104364 11830470 19950764 17895512 15335186 11603394 18702877 16243775 11773578 9496863 9930556 9469632 16355099 12941044 16138352 11530963 11588041
25	HRG	Histidine Rich Glycoprotein	Protein Coding	27.35	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	7772521 8475479 9414276
26	MTHFR	Methylenetetrahydrofolate Reductase	Protein Coding	27.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12469051 19748043 10634828 (more) 19538716 10770658 11896528 9493571 9054653 10365747 12454577 17911197 19353312 19556632 20017223 11025596 9327760 10893069 17008978 16411416 15114606 12477269 11385320 15952099 14714317 14580229 11085290 15570301 15216546 14669613 12413583 11755949 11479844 17908667 12221667 11146461 18682947 10365746 10235461 9733454 9715796 19366086 18261566 16980165 15896655 19211287 15479893 15692239 11084577 10780318 10212920 10192659 9869151 16080493 15897349 16305681 16432849 18030499 19824427 10650848
27	CD55	CD55 Molecule (Cromer Blood Group)	Protein Coding	26.04	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Disorders Publications (show sections)	11023512
28	P2RY12	Purinergic Receptor P2Y12	Protein Coding	25.85	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19476973 14597584 19660606 (more) 10960076 16234484
29	F8	Coagulation Factor VIII	Protein Coding	25.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11380453 14635611 16732372 (more) 17059421 15735796 15213843 16689758 16482798 14717970 20174619 15606555 17804532 19853891 20182352 10669146 15199517 12487836 16052298 20231535 16416741 9690808 18544592 15580358 15567468 12393556 8490173 19309248 11843285 14667103 8456319 15662616 15086321 14579789 17209060 14598591 12439142 11757243 9798969 11886394 12372929 15353485
30	PROCR	Protein C Receptor	Protein Coding	25.54	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11238108 11445739 15304035 (more) 18514072 19236779 11496851 17849044 14576048 19041722 12421141 16409473 17049585 12413583 11686348 16764648
31	ADAMTS13	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13	Protein Coding	25.43	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16201838 14631548 19180123 (more) 20058209 17173498 16409158 15497097 18299685 17432215 17608762 17146059 18272039 19687510 20432945 20441760 15009458 15561695 19027144 20075158 15975930 20307901 12901144
32	GP6	Glycoprotein VI Platelet	Protein Coding	25.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15150079 16788317 18585516 (more) 8735822 17848620 18479215 17096916
33	VKORC1	Vitamin K Epoxide Reductase Complex Subunit 1	Protein Coding	24.98	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
34	SERPIND1	Serpin Family D Member 1	Protein Coding	24.6	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
35	F2R	Coagulation Factor II Thrombin Receptor	Protein Coding	24.26	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20445954 10669659 14529396 (more) 11408522 12538843 10393336 17151288 12556215 19890703 9340367 19601827 11602852 19882073 10535908 11804648 15317288 17577318 12161502 20131237
36	F7	Coagulation Factor VII	Protein Coding	24.04	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18282149 8086403 9301633 (more) 11143761 9885217 7605983 9609255 19577483 20231535
37	F11	Coagulation Factor XI	Protein Coding	23.78	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12689935 18384352 19718468 (more) 8757530 15199517 16961605 16919078 18945968 20139363 15479396
38	SERPINF2	Serpin Family F Member 2	Protein Coding	23.73	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	7692999 7495059 11474570 (more) 17883703
39	VASP	Vasodilator Stimulated Phosphoprotein	Protein Coding	23.62	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Proteins (show sections)
40	CPB2	Carboxypeptidase B2	Protein Coding	22.93	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19195685 17127436 19719827 (more) 12958609 17216805 16181987
41	F13B	Coagulation Factor XIII B Chain	Protein Coding	22.86	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Pathways & Interactions (show sections)
42	CD40LG	CD40 Ligand	Protein Coding	22.75	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17328943 8607123 10726005 (more) 12559629 19353696 12708902 8616093 14607202 18031797 16186418 12460867 16449315 11530994 17440049 12913790 15277394 17041380 7778571 15831808 16810523
43	SERPINA5	Serpin Family A Member 5	Protein Coding	22.42	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Summaries (show sections)
44	CYP4F2	Cytochrome P450 Family 4 Subfamily F Member 2	Protein Coding	22.26	DISEASES inferred ¹⁴ GeneCards inferred via : Disorders Publications (show sections)
45	SELPLG	Selectin P Ligand	Protein Coding	21.99	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16411399 19691482 17221329 (more) 15351841
46	ITGB3	Integrin Subunit Beta 3	Protein Coding	21.94	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18208809 15166939
47	PPBP	Pro-Platelet Basic Protein	Protein Coding	21.93	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11966476 20004006 9685818
48	ANXA5	Annexin A5	Protein Coding	21.8	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16449315 11123066 10522297 (more) 10684648 8172859 11035417 11375285 18285765 18692942 9704667 17053060 18490409 18827057 20353989 9219701 14658002 15507268 7824446 10203671 18476173 10968894 9814673 15242878
49	EPO	Erythropoietin	Protein Coding	21.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8068879 9716076 15377478 (more) 1457917 7605873 9219165 8355460 17446131 2266676 9132672 9804442 10406511 12217816 16406065 1837851 18713253 18588258 17911193 10770972 16208643 12455569 19394731 19324483 10688281 8418623 18278812 16649374 10479636 9894755 9849735 7800210 8488954 19017170 15247979 12424426 12372966 10613225 7645539 8318683 7880205 8649623 1808758 1682739 19804272 16953562 16673278 15249178 15072509 11987310 14508840 12846770 19938039 7728837 2057440 7789287 9102827
50	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	21.57	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12161502 15707890 20131237 (more) 16332977 10535908 11001069 12538843 11487018

Sources

Variations for Thrombosis

Sources

Expression for Thrombosis

Search GEO for disease gene expression data for Thrombosis.

Sources

Pathways for Thrombosis

Pathways related to Thrombosis according to GeneCards Suite gene sharing:

(show all 26)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁶ Show member pathways Post-translational protein modification ⁶⁶	13.85	SERPINC1 SERPINA10 PROS1 PROC PLG FGG
2	Signal Transduction ⁶⁶	13.68	F2 F3 FGA FGB FGG JAK2
3	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways "Platelet activation, signaling and aggregation" ⁶⁶ Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet degranulation ⁶⁶	13.3	APOH F13A1 F2 F3 F5 F9
4	Development Angiotensin activation of ERK ²² Show member pathways Cell adhesion Integrin inside-out signaling ²² Development ACM2 and ACM4 activation of ERK ²² Development Angiotensin signaling via PYK2 ²² Development EDNRB signaling ²² Development EPO-induced MAPK pathway ²² Development G-Proteins mediated regulation MARK-ERK signaling ²² Signal transduction IP3 signaling ²²	12.73	JAK2 FGG FGB FGA F2
5	Extracellular matrix organization ⁶⁶ Show member pathways Degradation of the extracellular matrix ⁶⁶	12.65	VWF PLG FGG FGB FGA
6	Complement cascade ⁶⁶ Show member pathways Activation of C3 and C5 ⁶⁶ Classical Complement Pathway ⁶⁴ Complement Pathway ⁶⁴ Complement system ⁷⁴ Complement system in neuronal development and plasticity ⁷⁴ Lectin Induced Complement Pathway ⁶⁴ Regulation of Complement cascade ⁶⁶	12.6	PROS1 PLG FGG FGB FGA F2
7	Signaling downstream of RAS mutants ⁶⁶ Show member pathways MAP2K and MAPK activation ⁶⁶ Negative regulation of MAPK pathway ⁶⁶ Paradoxical activation of RAF signaling by kinase inactive BRAF ⁶⁶ RAF activation ⁶⁶ Signaling by high-kinase activity BRAF mutants ⁶⁶ Signaling by moderate kinase activity BRAF mutants ⁶⁶ Signaling by RAF1 mutants ⁶⁶ Signaling by RAS mutants ⁶⁶	12.58	VWF JAK2 FGG FGB FGA
8	Diseases of hemostasis ⁶⁶ Show member pathways Blood clotting cascade ⁷⁴ Blood Coagulation Signaling Pathways ⁶⁵ Common Pathway of Fibrin Clot Formation ⁶⁶ Complement and coagulation cascades ⁷⁴ Defective F8 binding to von Willebrand factor ⁶⁶ Defective F8 cleavage by thrombin ⁶⁶ Defective F8 sulfation at Y1699 ⁶⁶ Defective F9 activation ⁶⁶ Defective F9 secretion ⁶⁶ Defective factor IX causes hemophilia B ⁶⁶ Defective factor VIII causes hemophilia A ⁶⁶ Defective factor XII causes hereditary angioedema ⁶⁶ Defective gamma-carboxylation of F9 ⁶⁶ Defects of contact activation system (CAS) and kallikrein/kinin system (KKS) ⁶⁶ Extrinsic Pathway of Fibrin Clot Formation ⁶⁶ Extrinsic Prothrombin Activation Pathway ⁶⁴ Formation of Fibrin Clot (Clotting Cascade) ⁶⁶ Intrinsic Pathway of Fibrin Clot Formation ⁶⁶ Thrombin/protease-activated receptor (PAR) pathway ⁶¹	12.54	F13A1 F2 F3 F5 F9 FGA
9	Collagen chain trimerization ⁶⁶ Show member pathways Anchoring fibril formation ⁶⁶ Assembly of collagen fibrils and other multimeric structures ⁶⁶ Blood Coagulation Cascade ⁶⁴ Collagen biosynthesis and modifying enzymes ⁶⁶ Collagen degradation ⁶⁶ Collagen formation ⁶⁶ Crosslinking of collagen fibrils ⁶⁶ Intrinsic Prothrombin Activation Pathway ⁶⁴	12.47	F13A1 F2 F3 F5 F9 FGA
10	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) ⁶⁶ Show member pathways Post-translational protein phosphorylation ⁶⁶	12.34	SERPINC1 SERPINA10 PROC PLG FGG FGA
11	MET promotes cell motility ⁶⁶ Show member pathways Beta1 integrin cell surface interactions ⁶¹ MET activates PTK2 signaling ⁶⁶ MET activates RAP1 and RAC1 ⁶⁶ MET activates RAS signaling ⁶⁶ MET interacts with TNS proteins ⁶⁶ MET Receptor Activation ⁶⁶ MET receptor recycling ⁶⁶ Signaling by MET ⁶⁶	12.32	FGG FGB FGA F13A1
12	Cell surface interactions at the vascular wall ⁶⁶ Show member pathways Fibronectin matrix formation ⁶⁶ PECAM1 interactions ⁶⁶ Tie2 Signaling ⁶⁶	12.14	THBD PROS1 PROC F2
13	ECM proteoglycans ⁶⁶ Show member pathways Integrin cell surface interactions ⁶⁶ MED and pseudoachondroplasia genes ⁷⁴	12.11	FGA FGB FGG VWF
14	Oncogenic MAPK signaling ⁶⁶ Show member pathways Signaling by BRAF and RAF1 fusions ⁶⁶	12.11	VWF JAK2 FGG FGB FGA
15	"Gamma carboxylation, hypusine formation and arylsulfatase activation" ⁶⁶ Show member pathways "Gamma-carboxylation, transport, and amino-terminal cleavage of proteins" ⁶⁶ diphthamide biosynthesis ⁶¹ Gamma-carboxylation of protein precursors ⁶⁶ hypusine biosynthesis ⁶¹ Hypusine synthesis from eIF5A-lysine ⁶⁶ Removal of aminoterminal propeptides from gamma-carboxylated proteins ⁶⁶ Synthesis of diphthamide-EEF2 ⁶⁶ The activation of arylsulfatases ⁶⁶ Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus ⁶⁶	11.89	PROS1 PROC F9 F2
16	Integrin signaling ⁶⁶ Show member pathways GRB2:SOS provides linkage to MAPK signaling for Integrins ⁶⁶ p130Cas linkage to MAPK signaling for integrins ⁶⁶ Platelet Aggregation (Plug Formation) ⁶⁶	11.86	VWF GP1BA FGG FGB FGA F2
17	"Platelet Aggregation Inhibitor Pathway, Pharmacodynamics" ⁶⁰	11.58	VWF FGG FGB FGA F2
18	Cell adhesion_Plasmin signaling ²²	11.54	FGA FGB FGG PLAT PLG
19	Fibrin complement receptor 3 signaling pathway ⁷⁴	11.46	PLG PLAT FGG FGB FGA
20	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ⁶¹	11.42	FGA FGB FGG PLG
21	Beta3 integrin cell surface interactions ⁶¹	11.33	FGG FGB FGA
22	"Warfarin Pathway, Pharmacodynamics" ⁶⁰ Show member pathways Vitamin K metabolism and activation of dependent proteins ⁷⁴ vitamin K-epoxide cycle ⁶¹	11.33	PROS1 PROC F9 F2
23	Beta2 integrin cell surface interactions ⁶¹	11.26	FGA FGB FGG GP1BA PLAT PROC
24	Syndecan-4-mediated signaling events ⁶¹	11.23	TFPI PLG F2
25	Dissolution of Fibrin Clot ⁶⁶	10.74	PLG PLAT
26	"COVID-19, thrombosis and anticoagulation" ⁷⁴	9.95	F13A1 F2 FGA FGB FGG PLG

Sources

GO Terms for Thrombosis

Cellular components related to Thrombosis according to GeneCards Suite gene sharing:

(show all 13)

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	10.61	APOH F2 F9 FGA FGB FGG
2	extracellular region	GO:0005576	10.53	APOH F13A1 F2 F3 F5 F9
3	cell surface	GO:0009986	10.4	APOH F3 FGA FGB FGG GP1BA
4	endoplasmic reticulum lumen	GO:0005788	10.34	F2 F5 F9 FGA FGG PROC
5	external side of plasma membrane	GO:0009897	10.29	THBD GP1BA FGG FGB FGA F3
6	blood microparticle	GO:0072562	10.16	F13A1 F2 FGA FGB FGG PLG
7	Golgi lumen	GO:0005796	10.13	PROS1 PROC F9 F2
8	platelet alpha granule	GO:0031091	10.07	VWF FGG FGB FGA F5
9	serine-type endopeptidase complex	GO:1905370	10.06	THBD PROC F9 F2
10	platelet alpha granule lumen	GO:0031093	10.06	VWF PROS1 PLG FGG FGB FGA
11	collagen-containing extracellular matrix	GO:0062023	10.02	APOH F13A1 F2 F3 F9 FGA
12	fibrinogen complex	GO:0005577	9.95	FGG FGB FGA
13	extracellular space	GO:0005615	9.9	APOH F13A1 F2 F3 F5 F9

Biological processes related to Thrombosis according to GeneCards Suite gene sharing:

(show all 29)

#	Name	GO ID	Score	Top Affiliating Genes
1	proteolysis	GO:0006508	10.4	F2 F9 PLAT PLG PROC THBD
2	blood coagulation	GO:0007596	10.37	F13A1 F2 F3 F5 F9 FGA
3	negative regulation of endopeptidase activity	GO:0010951	10.22	TFPI SERPINC1 SERPINA10 PROS1
4	response to calcium ion	GO:0051592	10.11	FGG FGB FGA
5	platelet aggregation	GO:0070527	10.11	GP1BA FGG FGB FGA
6	positive regulation of protein secretion	GO:0050714	10.09	FGG FGB FGA
7	platelet activation	GO:0030168	10.09	VWF GP1BA FGG FGB FGA F2
8	positive regulation of substrate adhesion-dependent cell spreading	GO:1900026	10.08	FGG FGB FGA
9	negative regulation of endothelial cell apoptotic process	GO:2000352	10.07	FGA FGB FGG
10	positive regulation of vasoconstriction	GO:0045907	10.05	FGG FGB FGA
11	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	GO:1902042	10.04	FGG FGB FGA
12	positive regulation of exocytosis	GO:0045921	10.03	FGG FGB FGA
13	negative regulation of blood coagulation	GO:0030195	10.02	APOH PROC PROS1 TFPI THBD
14	negative regulation of fibrinolysis	GO:0051918	10.02	THBD PLG PLAT F2 APOH
15	protein polymerization	GO:0051258	10.01	FGA FGB FGG
16	blood coagulation, fibrin clot formation	GO:0072378	10.01	FGG FGB FGA F13A1
17	positive regulation of heterotypic cell-cell adhesion	GO:0034116	10	FGG FGB FGA
18	positive regulation of peptide hormone secretion	GO:0090277	9.97	FGG FGB FGA
19	plasminogen activation	GO:0031639	9.96	APOH FGA FGB FGG PLAT
20	regulation of blood coagulation	GO:0030193	9.95	APOH F2 GP1BA SERPINC1
21	positive regulation of platelet activation	GO:0010572	9.94	JAK2 GP1BA
22	negative regulation of platelet activation	GO:0010544	9.94	THBD F2
23	blood coagulation, intrinsic pathway	GO:0007597	9.93	GP1BA APOH
24	induction of bacterial agglutination	GO:0043152	9.91	FGB FGA
25	hemostasis	GO:0007599	9.91	F13A1 F2 F3 F5 F9 FGA
26	trans-synaptic signaling by BDNF, modulating synaptic transmission	GO:0099183	9.88	PLG PLAT
27	blood coagulation, common pathway	GO:0072377	9.85	THBD FGA
28	regulation of body fluid levels	GO:0050878	9.76	PROC F9 F5 F2
29	fibrinolysis	GO:0042730	9.53	F2 FGA FGB FGG GP1BA PLAT

Molecular functions related to Thrombosis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	signaling receptor binding	GO:0005102	10	F2 FGA FGB FGG JAK2 PLAT
2	heparin binding	GO:0008201	9.97	SERPINC1 SERPINA10 F2 APOH
3	extracellular matrix structural constituent	GO:0005201	9.86	VWF FGG FGB FGA
4	peptidase activity	GO:0008233	9.72	PROC PLG PLAT F9 F2
5	serine-type peptidase activity	GO:0008236	9.43	PROC PLG PLAT F9 F2
6	serine-type endopeptidase activity	GO:0004252	9.4	PROC PLG PLAT F9 F3 F2