MCID: THR123
MIFTS: 41

Thrombotic Microangiopathy

Categories: Blood diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Thrombotic Microangiopathy

MalaCards integrated aliases for Thrombotic Microangiopathy:

Name: Thrombotic Microangiopathy 59 33

Classifications:

Orphanet: 59  
Rare renal diseases


External Ids:

ICD10 33 M31.1
MESH via Orphanet 45 D057049
UMLS via Orphanet 73 C2717961
Orphanet 59 ORPHA93573

Summaries for Thrombotic Microangiopathy

MalaCards based summary : Thrombotic Microangiopathy is related to de novo thrombotic microangiopathy after kidney transplantation and thrombotic thrombocytopenic purpura, congenital. An important gene associated with Thrombotic Microangiopathy is ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13), and among its related pathways/superpathways are Innate Immune System and Creation of C4 and C2 activators. The drugs Lactulose and Magnesium Sulfate have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and bone, and related phenotypes are hematopoietic system and pigmentation

Wikipedia : 75 Thrombotic microangiopathy (TMA) is a pathology that results in thrombosis in capillaries and... more...

Related Diseases for Thrombotic Microangiopathy

Diseases related to Thrombotic Microangiopathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 480)
# Related Disease Score Top Affiliating Genes
1 de novo thrombotic microangiopathy after kidney transplantation 34.1 CFI CFH
2 thrombotic thrombocytopenic purpura, congenital 33.8 CFH ADAMTS13
3 catastrophic antiphospholipid syndrome 33.0 CFH ADAMTS13
4 purpura 32.2 VWF ADAMTS13
5 thrombotic thrombocytopenic purpura 31.8 VWF CFH CD46 ADAMTS13
6 antiphospholipid syndrome 31.5 VWF ADAMTS13
7 acute kidney failure 31.5 CFH ADAMTS13
8 hemolytic anemia 31.2 CFI CFH ADAMTS13
9 vasculitis 30.4 VWF CFI
10 thrombosis 30.3 VWF ADAMTS13
11 membranoproliferative glomerulonephritis 30.2 CFH CD46
12 glomerulonephritis 30.1 CFI CFH CD46
13 methylmalonic aciduria and homocystinuria, cblc type 29.9 CD46 ADAMTS13
14 angiosarcoma 29.9 VWF VEGFA
15 yemenite deaf-blind hypopigmentation syndrome 29.8 VEGFA CFH
16 peripheral vascular disease 29.6 VWF VEGFA
17 hemolytic-uremic syndrome 29.5 VWF CFI CFH CD46 ADAMTS13
18 complement factor h deficiency 29.4 CFI CFH CD46
19 myocardial infarction 29.2 VWF VEGFA ADAMTS13
20 hemolytic uremic syndrome, atypical 1 29.1 VWF CFI CFH CD46 ADAMTS13
21 enterocolitis 28.9 CFI CFH CD46
22 malaria 28.8 VWF VEGFA ADAMTS13
23 hellp syndrome 28.6 VWF CFI CFH CD46 ADAMTS13
24 genetic thrombotic microangiopathy 12.4
25 thrombocytopenia 11.1
26 thrombotic thrombocytopenic purpura, acquired 11.0
27 hematopoietic stem cell transplantation 10.8
28 graft-versus-host disease 10.8
29 pulmonary hypertension 10.8
30 malignant hypertension 10.7
31 kidney disease 10.7
32 systemic lupus erythematosus 10.7
33 end stage renal failure 10.7
34 disseminated intravascular coagulation 10.7
35 acute graft versus host disease 10.7
36 respiratory failure 10.6
37 pre-eclampsia 10.6
38 lupus erythematosus 10.6
39 nephrotic syndrome 10.6
40 gastric adenocarcinoma 10.5
41 myeloma, multiple 10.5
42 autoimmune disease 10.5
43 systemic scleroderma 10.5
44 chronic kidney disease 10.5
45 gastric cancer 10.5
46 diarrhea 10.5
47 immune deficiency disease 10.4
48 eclampsia 10.4
49 acute kidney tubular necrosis 10.4
50 pulmonary embolism 10.4

Graphical network of the top 20 diseases related to Thrombotic Microangiopathy:



Diseases related to Thrombotic Microangiopathy

Symptoms & Phenotypes for Thrombotic Microangiopathy

MGI Mouse Phenotypes related to Thrombotic Microangiopathy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 ADAMTS13 CFH CFI VEGFA VWF
2 pigmentation MP:0001186 9.13 ADAMTS13 CD46 CFH
3 vision/eye MP:0005391 8.92 ADAMTS13 CD46 CFH VEGFA

Drugs & Therapeutics for Thrombotic Microangiopathy

Drugs for Thrombotic Microangiopathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 101)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lactulose Approved Phase 4 4618-18-2 11333
2
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
3
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
4
Remifentanil Approved Phase 4 132875-61-7 60815
5
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
6 Analgesics Phase 4
7 Hormones Phase 4
8 Tocolytic Agents Phase 4
9 Central Nervous System Depressants Phase 4
10 Anti-Arrhythmia Agents Phase 4
11 Anesthetics Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Anticonvulsants Phase 4
14 Calcium, Dietary Phase 4
15 calcium channel blockers Phase 4
16 Anesthetics, Local Phase 4
17 Sodium Channel Blockers Phase 4
18 Narcotics Phase 4
19 Diuretics, Potassium Sparing Phase 4
20 Analgesics, Opioid Phase 4
21
Acetylcysteine Approved, Investigational Phase 3 616-91-1 12035
22
Sargramostim Approved, Investigational Phase 3 83869-56-1, 123774-72-1
23
Mesna Approved, Investigational Phase 3 3375-50-6 598
24
leucovorin Approved Phase 3 58-05-9 143 6006
25
Sodium citrate Approved, Investigational Phase 3 68-04-2
26
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
27
Lenograstim Approved, Investigational Phase 3 135968-09-1
28
Folic acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
29
Citric acid Approved, Nutraceutical, Vet_approved Phase 3 77-92-9 311
30 N-monoacetylcystine Phase 3
31 Respiratory System Agents Phase 3
32 Antidotes Phase 3
33 Antioxidants Phase 3
34 Free Radical Scavengers Phase 3
35 Protective Agents Phase 3
36 Expectorants Phase 3
37 Antiviral Agents Phase 3
38 Anticoagulants Phase 3
39 Coagulants Phase 3
40 Alkylating Agents Phase 3
41 Folic Acid Antagonists Phase 3
42 Citrate Phase 3
43 Vitamin B9 Phase 3
44 Nucleic Acid Synthesis Inhibitors Phase 3
45 Folate Phase 3
46 Vitamin B Complex Phase 3
47 Dermatologic Agents Phase 3
48 Cyclosporins Phase 3
49 Antimetabolites, Antineoplastic Phase 3
50 Antimetabolites Phase 3

Interventional clinical trials:

(show all 31)
# Name Status NCT ID Phase Drugs
1 Phase 4 Study :Human Kidney Histopathology in Acute Obstructive Jaundice: a Prospective Study Completed NCT01090193 Phase 4
2 Effect of Intravenous Infusion of Lidocaine, Magnesium Sulphate and Remifentanil Perioperatively in Patients Undergoing Mastectomy: a Prospective, Randomized and Double-blind Study Completed NCT02309879 Phase 4 Remifentanil infusion;Lidocaine infusion;Magnesium sulphate infusion;Magnesium sulphate and Lidocaine infusion
3 Evaluation of Potential Predictors of Disease Progression in Patients With aHUS, Including Genetics, Biomarkers and Treatment Active, not recruiting NCT02614898 Phase 4
4 A Safety and Efficacy Study of N-acetylcysteine in Patients With Hematopoietic Stem Cell Transplantation Associated Thrombotic Microangiopathy Recruiting NCT03252925 Phase 3 N-Acetylcysteine;Placebo Oral Tablet
5 A Randomized, Multi-Center, Phase III Trial of Calcineurin Inhibitor-Free Interventions for Prevention of Graft-versus-Host Disease (BMT CTN #1301; Progress II) Active, not recruiting NCT02345850 Phase 3 Cyclophosphamide;Tacrolimus;Methotrexate
6 Interest of Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care: Multicentric Randomized Controlled Trial Not yet recruiting NCT03237819 Phase 3 Sulfate, Magnesium;Placebo - Concentrate
7 An Open-label, Multi-center Clinical Trial of Eculizumab in Adult Patients With Atypical Hemolytic-uremic Syndrome Completed NCT01194973 Phase 2 Eculizumab
8 A Phase II Study of Sirolimus, Tacrolimus and Thymoglobulin®, as Graft-versus-Host- Disease Prophylaxis in Patients Undergoing Unrelated Donor Hematopoietic Cell Transplantation Completed NCT00691015 Phase 2 busulfan;carmustine;cyclophosphamide;cytarabine;etoposide;fludarabine phosphate;melphalan;anti-thymocyte globulin IV
9 Early Intervention With Eculizumab to Treat Thrombotic Microangiopathy/Atypical Hemolytic Uremic Syndrome (TMA/aHUS)-Associated Multiple Organ Dysfunction Syndrome (MODS) in Hematopoietic Stem Cell Transplant (HCT) Recipients Recruiting NCT03518203 Phase 2 Eculizumab
10 A Pilot Trial of Using Pre-Transplant Risk Stratification and Prophylactic Defibrotide to Prevent Serious Thrombotic Microangiopathy in High-Risk Hematopoietic Stem Cell Transplant Patients Recruiting NCT03384693 Phase 2 Defibrotide
11 HLA-Identical Sibling Donor Bone Marrow Transplantation for Individuals With Severe Sickle Cell Disease Using a Reduced Intensity Conditioning Regimen Recruiting NCT02776202 Phase 2 Fludarabine monophosphate
12 A Phase II, Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Safety and Efficacy of Cemdisiran (ALN-CC5) Following Withdrawal of Chronic Eculizumab Therapy in Patients With Atypical HUS at High Risk of Recurrence Not yet recruiting NCT03999840 Phase 2 cemdisiran;Placebos
13 A Randomized, Double-blind, Placebo Controlled, Clinical Outcome Study of ARC1779 Injection in Patients With Thrombotic Microangiopathy Terminated NCT00726544 Phase 2 ARC 1779 Placebo;ARC1779 Injection;ARC1779 Injection;ARC1779 Injection
14 Multicenter Trials to Evaluate the Efficacy and Toxicity of Sirolimus/Tacrolimus Combination as a GVHD Prophylaxis After HLA Matched Related PBSCT Terminated NCT01488253 Phase 2 Sirolimus;Tacrolimus
15 A Pilot Phase II Study of Sirolimus, Tacrolimus, Thymoglobulin and Rituximab as Graft-versus-Host-Disease Prophylaxis in Patients Undergoing Haploidentical and HLA Partially Matched Donor Hematopoietic Cell Transplantation Terminated NCT01116232 Phase 2 sirolimus;tacrolimus
16 A Phase 2, Open Label, Multicenter Study of ALN-CC5 Administered Subcutaneously in Adult Patients With Atypical Hemolytic Uremic Syndrome Withdrawn NCT03303313 Phase 2 Cemdisiran
17 Study of 'Vascular Competence' Profile and Endothelial Activation in the Hemolytic Uremic Syndrome in Children and Adults Unknown status NCT02904863
18 Screening of TMA Patients for ADAMTS13 Activity and the Description of Systematic Organ Damage and/or Organ Failure in Different Entities of Thrombotic Microangiopathies (TMA) Unknown status NCT02373267
19 Pathogenesis, Diagnosis, Management and Outcome of Hemostatic Complications in Hematopoietic Stem Cell Transplantation: A Prospective Study Unknown status NCT02281240 thrombopoietin, interleukin-11, heparin,
20 Research Network for Neonatal Diseases Induced by Tissular Fetomaternal Alloimmunization Completed NCT00199628
21 Assessment of Immature Platelet Fraction in Pregnancy-Associated Thrombotic Microangiopathy Completed NCT03232359
22 Identification of Early Predictive Factors of Cardiac and Cerebral Involvement in Thrombotic Microangiopathies Completed NCT02134171
23 Identification of the Pathogenesis of Thrombotic Microangiopathy in the Allo Stem Cell Transplant Setting in Adults Completed NCT02604420 eculizumab
24 ADAMTS13-related Prognostic Factors in Adult and Pediatric Thrombotic Thrombocytopenic Purpura Completed NCT00426686
25 An Observational, Non-Interventional, Multi-Center, Multi-National Study of Patients With Atypical Hemolytic-Uremic Syndrome (aHUS Registry) Recruiting NCT01522183
26 Azithromycin in Post Diarrheal Haemolytic and Uremic Syndrome Recruiting NCT02336516 Azithromycin;Placebo (glucose solution 10%)
27 Renal Biopsy Findings In Patients With Unexplained Elevated Serum Creatinine In Assiut University Hospital Active, not recruiting NCT03586531
28 Usefulness of a Diagnostic Algorithm to Diagnose Thrombotic Microangiopathies in Pregnancy Active, not recruiting NCT03580941
29 Eculizumab Use in the Postpartum Period for the Treatment of Pregnancy Associated Atypical Hemolytic Uremic Syndrome: A Case Series Active, not recruiting NCT03574506
30 Provision of OMS721 to Patients With Thrombotic Microangiopathy Under Compassionate Use Available NCT02355782
31 An Observational Study of All Forms of Thrombotic Microangiopathy in Pediatric Patients Terminated NCT00593229

Search NIH Clinical Center for Thrombotic Microangiopathy

Genetic Tests for Thrombotic Microangiopathy

Anatomical Context for Thrombotic Microangiopathy

MalaCards organs/tissues related to Thrombotic Microangiopathy:

41
Kidney, Endothelial, Bone, Bone Marrow, Liver, Lung, Breast

Publications for Thrombotic Microangiopathy

Articles related to Thrombotic Microangiopathy:

(show top 50) (show all 2944)
# Title Authors PMID Year
1
Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy. 38
31334000 2019
2
Membranous nephropathy and thrombotic microangiopathy secondary to metastatic prostate cancer after Iodine-125 prostate brachytherapy: A case report
. 38
31262399 2019
3
Adverse outcomes in obstetric-atypical haemolytic uraemic syndrome: a case series analysis. 38
29606012 2019
4
Role of therapeutic plasma exchange in snake bite associated thrombotic microangiopathy-A case report with review of literature. 38
30779435 2019
5
Primary antiphospholipid syndrome presented as thrombotic microangiopathy in renal transplantation. 38
31431303 2019
6
Pulmonary tumour thrombotic microangiopathy: a rare but underappreciated complication of malignancy. 38
31420874 2019
7
Circulating Heme Oxygenase-1 and Complement Activation in Transplant-Associated Thrombotic Microangiopathy. 38
30871975 2019
8
Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy. 38
31409673 2019
9
Immunological Reconstitution Inflammatory Syndrome and Thrombotic Microangiopathy: Severe Complications in a Child With Acquired Immunodeficiency Syndrome. 38
31179739 2019
10
Engraftment syndrome, transplant-associated thrombotic microangiopathy and hemophagocytic syndrome following autologous stem cell transplant in multiple myeloma. 38
31090118 2019
11
Clinical Characteristics of Heart Failure from Case Reports Presented at the Regional Meeting of the Japanese Society of Internal Medicine. 38
31178494 2019
12
Hyperhomocysteinemia: a trigger for complement-mediated TMA? 38
31401947 2019
13
How I investigate bone marrow necrosis. 38
31424633 2019
14
Secondary thrombotic microangiopathy in systemic lupus erythematosus and antiphospholipid syndrome, the role of complement and use of eculizumab: Case series and review of literature. 38
30598332 2019
15
Plasma exchange in lupus nephritis with thrombotic microangiopathy. 38
31044483 2019
16
A case off TTP temporally associated with cocaine use: Implications for treatment of suspected DITMA. 38
30776151 2019
17
Rare cause of pulmonary hypertension - pulmonary tumour thrombotic microangiopathy. 38
31401584 2019
18
Kidney biopsy findings in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study. 38
30945006 2019
19
Clinical-pathological correlations in post-transplant thrombotic microangiopathy. 38
30851188 2019
20
Efficacy and safety of plasma exchange using a double viral inactivated and prion reduced solvent/detergent fresh frozen plasma for the treatment of thrombotic microangiopathy: The first French experience in a single center. 38
31331708 2019
21
Successful treatment with eculizumab for posterior reversible encephalopathy syndrome due to underlying transplant-associated thrombotic microangiopathy in patients transplanted for sickle cell disease. 38
31264793 2019
22
Clinical and morphological practices in the diagnosis of transplant-associated microangiopathy: a study on behalf of Transplant Complications Working Party of the EBMT. 38
30361500 2019
23
Cutaneous and Renal Glomerular Vasculopathy: What Do We Know so Far? 38
30961997 2019
24
[A Case of Thrombotic Microangiopathy Arising from Breast Cancer Treated with Chemotherapy]. 38
31296827 2019
25
Association of vascular endothelial growth factor and renal thrombotic microangiopathy-like lesions in patients with Castleman's disease. 38
31264312 2019
26
Nephrotoxicity: Role and significance of renal biomarkers in the early detection of acute renal injury. 38
31334089 2019
27
The pathology of solid organ xenotransplantation. 38
31348015 2019
28
Anticoagulation in patients with concomitant lupus nephritis and thrombotic microangiopathy: a multicentre cohort study. 38
30552172 2019
29
[First diagnosis of systemic sclerosis based on ocular complications]. 38
30218373 2019
30
Linking Complement Activation, Coagulation, and Neutrophils in Transplant-Associated Thrombotic Microangiopathy. 38
31266080 2019
31
Terminal complement effectors in atypical hemolytic uremic syndrome: C5a, C5b-9, or a bit of both? 38
31229026 2019
32
Pharmacology, Pharmacokinetics and Pharmacodynamics of Eculizumab, and Possibilities for an Individualized Approach to Eculizumab. 38
30758736 2019
33
[Kidney disease in cobalamin C deficiency]. 38
31130431 2019
34
Thrombotic microangiopathy revealed by a coma. 38
31301915 2019
35
Differential contribution of C5aR and C5b-9 pathways to renal thrombic microangiopathy and macrovascular thrombosis in mice carrying an atypical hemolytic syndrome-related factor H mutation. 38
30910380 2019
36
Kidney Injury in Murine Models of Hematopoietic Stem Cell Transplantation. 38
31271886 2019
37
Current status of hepatopulmonary syndrome in liver transplantation in Japan: a Japanese multicenter analysis. 38
31069999 2019
38
Value of renal gene panel diagnostics in adults waiting for kidney transplantation due to undetermined end-stage renal disease. 38
31027891 2019
39
[Pulmonary tumour thrombotic microangiopathy associated with a gastric adenocarcinoma]. 38
31373460 2019
40
A critical role of the Gas6-Mer axis in endothelial dysfunction contributing to TA-TMA associated with GVHD. 38
31300420 2019
41
Loss of von Willebrand factor high-molecular-weight multimers at acute phase is associated with detectable anti-ADAMTS13 IgG and neurological symptoms in acquired thrombotic thrombocytopenic purpura. 38
31330376 2019
42
Posterior reversible encephalopathy syndrome in stroke-prone spontaneously hypertensive rats on high-salt diet. 38
29350576 2019
43
An Immunocompetent Case of Capnocytophaga canimorsus Infection Complicated by Secondary Thrombotic Microangiopathy and Disseminated Intravascular Coagulation. 38
31327837 2019
44
Gastrointestinal infection-related disseminated intravascular coagulation mimicking Shiga toxin-mediated hemolytic uremic syndrome - implications of classical clinical indexes in making the diagnosis: A case report and literature review. 38
31367625 2019
45
Novel Detection of CALR-Mutated Cells in Myeloproliferative Neoplasm-Related Glomerulopathy With Interstitial Extramedullary Hematopoiesis: A Case Report. 38
31377025 2019
46
Norovirus: a novel etiologic agent in hemolytic uremic syndrome in an infant. 38
31277594 2019
47
Escherichia coli-associated hemolytic uremic syndrome and severe chronic hepatocellular cholestasis: complication or side effect of eculizumab? 38
30963282 2019
48
Transplant-associated thrombotic microangiopathy: is the treatment more expensive than the disease? 38
30413812 2019
49
Biopsy-proven thrombotic microangiopathy without schistocytosis on peripheral blood smear: A cautionary tale. 38
31175815 2019
50
Antiphospholipid antibodies and renal transplant: A systematic review and meta-analysis. 38
30449651 2019

Variations for Thrombotic Microangiopathy

Expression for Thrombotic Microangiopathy

Search GEO for disease gene expression data for Thrombotic Microangiopathy.

Pathways for Thrombotic Microangiopathy

GO Terms for Thrombotic Microangiopathy

Cellular components related to Thrombotic Microangiopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.62 VEGFA CFI CFH ADAMTS13
2 cell surface GO:0009986 9.43 VEGFA CD46 ADAMTS13
3 extracellular region GO:0005576 9.35 VWF VEGFA CFI CFH ADAMTS13
4 platelet alpha granule lumen GO:0031093 9.16 VWF VEGFA
5 extracellular matrix GO:0031012 8.62 VEGFA ADAMTS13

Biological processes related to Thrombotic Microangiopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.33 CFI CFH CD46
2 platelet degranulation GO:0002576 9.32 VWF VEGFA
3 platelet activation GO:0030168 9.26 VWF ADAMTS13
4 hemostasis GO:0007599 8.96 VWF ADAMTS13
5 regulation of complement activation GO:0030449 8.8 CFI CFH CD46

Molecular functions related to Thrombotic Microangiopathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integrin binding GO:0005178 8.62 VWF ADAMTS13

Sources for Thrombotic Microangiopathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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