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TTP
MCID: THR005
MIFTS: 64

Thrombotic Thrombocytopenic Purpura (TTP)

Categories: Blood diseases, Genetic diseases, Nephrological diseases, Neuronal diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Thrombotic Thrombocytopenic Purpura

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MalaCards integrated aliases for Thrombotic Thrombocytopenic Purpura:

Name: Thrombotic Thrombocytopenic Purpura 12 25 37 29 6 15 63
Purpura, Thrombotic Thrombocytopenic 76 25 44 73
Microangiopathic Hemolytic Anemia 25 73
Congenital Thrombotic Thrombocytopenic Purpura 73
Familial Thrombotic Thrombocytopenia Purpura 25
Familial Thrombotic Thrombocytopenic Purpura 73
Thrombotic Microangiopathy, Familial 25
Purpura Thrombotic Thrombocytopenic 55
Moschcowitz's Syndrome 12
Moschkowitz Disease 25
Ttp 25

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Blood diseases Nephrological diseases Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 33


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Summaries for Thrombotic Thrombocytopenic Purpura

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PubMed Health : 63 About thrombotic thrombocytopenic purpura: Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder. In TTP, blood clots form in small blood vessels throughout the body.The clots can limit or block the flow of oxygen-rich blood to the body's organs, such as the brain, kidneys, and heart. As a result, serious health problems can develop.The increased clotting that occurs in TTP also uses up platelets (PLATE-lets) in the blood. Platelets are blood cell fragments that help form blood clots. These cell fragments stick together to seal small cuts and breaks on blood vessel walls and stop bleeding.With fewer platelets available in the blood, bleeding problems can occur. People who have TTP may bleed inside their bodies, underneath the skin, or from the surface of the skin. When cut or injured, they also may bleed longer than normal."Thrombotic" (throm-BOT-ik) refers to the blood clots that form. "Thrombocytopenic" (throm-bo-cy-toe-PEE-nick) means the blood has a lower than normal number of platelets. "Purpura" (PURR-purr-ah) refers to purple bruises caused by bleeding under the skin.Bleeding under the skin also can cause tiny red or purple dots on the skin. These pinpoint-sized dots are called petechiae (peh-TEE-kee-ay). Petechiae may look like a rash.

MalaCards based summary : Thrombotic Thrombocytopenic Purpura, also known as purpura, thrombotic thrombocytopenic, is related to thrombotic thrombocytopenic purpura, congenital and purpura, and has symptoms including tremor and fever. An important gene associated with Thrombotic Thrombocytopenic Purpura is ADAMTS13 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 13), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and O-linked glycosylation. The drugs rituximab and Clopidogrel have been mentioned in the context of this disorder. Affiliated tissues include kidney, brain and heart, and related phenotypes are seizures and proteinuria

Genetics Home Reference : 25 Thrombotic thrombocytopenic purpura is a rare disorder that causes blood clots (thrombi) to form in small blood vessels throughout the body. These clots can cause serious medical problems if they block vessels and restrict blood flow to organs such as the brain, kidneys, and heart. Resulting complications can include neurological problems (such as personality changes, headaches, confusion, and slurred speech), fever, abnormal kidney function, abdominal pain, and heart problems.

Wikipedia : 76 Thrombotic thrombocytopenic purpura (TTP) is a blood disorder that results in blood clots forming in... more...

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Related Diseases for Thrombotic Thrombocytopenic Purpura

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Diseases in the Thrombotic Thrombocytopenic Purpura family:

Thrombotic Thrombocytopenic Purpura, Congenital Thrombotic Thrombocytopenic Purpura, Acquired

Diseases related to Thrombotic Thrombocytopenic Purpura via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 thrombotic thrombocytopenic purpura, congenital 34.8 CFH ADAMTS13
2 purpura 31.7 VWF THBD F3 APOH ADAMTS13
3 disseminated intravascular coagulation 30.6 THBD F3 ADAMTS13
4 hemolytic-uremic syndrome 30.6 VWF THBD F3 CFH CD46 ADAMTS13
5 thrombocytopenia 30.6 F3 APOH ADAMTS13
6 mixed connective tissue disease 30.5 APOH ADAMTS13
7 acute myocardial infarction 30.3 VWF SELP F3
8 coronary thrombosis 30.3 VWF F3
9 myocardial infarction 30.3 VWF THBD SELP F3 ADAMTS13
10 pulmonary hypertension 30.2 VWF THBD F3
11 spotted fever 30.2 VWF THBD
12 hemolytic uremic syndrome, atypical 1 30.1 VWF THBD CFH CD46 ADAMTS13
13 hemophilia 30.1 VWF F3
14 polyarteritis nodosa 30.1 SELE APOH
15 hemophilia a 30.0 VWF F3
16 hepatic veno-occlusive disease 30.0 THBD F3
17 systemic lupus erythematosus 30.0 VWF THBD SELE F3 CFH APOH
18 vasculitis 29.9 VWF THBD SELE APOH
19 retinal vascular occlusion 29.9 SELP APOH
20 thrombosis 29.9 VWF THBD SELP F3 APOH ADAMTS13
21 arteries, anomalies of 29.9 VWF SELP SELE F3
22 buerger disease 29.9 SELE APOH
23 membranoproliferative glomerulonephritis 29.9 CFH CD46
24 afibrinogenemia 29.8 VWF F3 CD46
25 hemorrhagic disease 29.8 VWF THBD F3 ADAMTS13
26 von willebrand's disease 29.8 VWF SELP F3 ADAMTS13
27 protein s deficiency 29.7 F3 APOH
28 thrombophilia 29.7 VWF THBD F3 APOH
29 essential thrombocythemia 29.7 VWF THBD SELP F3
30 pulmonary embolism 29.7 VWF F3 APOH
31 antiphospholipid syndrome 29.4 VWF THBD SELP SELE F3 APOH
32 catastrophic antiphospholipid syndrome 29.4 F3 CFH APOH ADAMTS13
33 pre-eclampsia 29.2 VWF THBD SELP SELE F3 APOH
34 hellp syndrome 29.2 VWF THBD F3 CFH CD46 APOH
35 vascular disease 29.0 VWF THBD SELP SELE F3 APOH
36 thrombotic thrombocytopenic purpura, acquired 13.0
37 nephrotic syndrome, type 7 11.5
38 hemolytic uremic syndrome, atypical 2 11.3
39 hemolytic uremic syndrome, atypical 3 11.3
40 hemolytic uremic syndrome, atypical 4 11.3
41 hemolytic uremic syndrome, atypical 5 11.3
42 hemolytic uremic syndrome, atypical 6 11.3
43 lupus erythematosus 10.8
44 pancreatitis 10.6
45 acute pancreatitis 10.5
46 connective tissue disease 10.5
47 hepatitis 10.4
48 adult-onset still's disease 10.4
49 myeloma, multiple 10.4
50 hemolytic anemia 10.4

Graphical network of the top 20 diseases related to Thrombotic Thrombocytopenic Purpura:



Diseases related to Thrombotic Thrombocytopenic Purpura
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Symptoms & Phenotypes for Thrombotic Thrombocytopenic Purpura

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Human phenotypes related to Thrombotic Thrombocytopenic Purpura:

32 (show all 20)
# Description HPO Frequency HPO Source Accession
1 seizures 32 frequent (33%) HP:0001250
2 proteinuria 32 occasional (7.5%) HP:0000093
3 fever 32 occasional (7.5%) HP:0001945
4 dyspnea 32 hallmark (90%) HP:0002094
5 generalized muscle weakness 32 hallmark (90%) HP:0003324
6 arrhythmia 32 occasional (7.5%) HP:0011675
7 myocardial infarction 32 occasional (7.5%) HP:0001658
8 abdominal pain 32 frequent (33%) HP:0002027
9 thrombocytopenia 32 hallmark (90%) HP:0001873
10 hematuria 32 occasional (7.5%) HP:0000790
11 coma 32 frequent (33%) HP:0001259
12 reticulocytosis 32 hallmark (90%) HP:0001923
13 diarrhea 32 frequent (33%) HP:0002014
14 stroke 32 frequent (33%) HP:0001297
15 headache 32 frequent (33%) HP:0002315
16 acute kidney injury 32 very rare (1%) HP:0001919
17 confusion 32 frequent (33%) HP:0001289
18 microangiopathic hemolytic anemia 32 hallmark (90%) HP:0001937
19 abnormal lactate dehydrogenase activity 32 frequent (33%) HP:0045040
20 decreased serum creatinine 32 very rare (1%) HP:0012101

UMLS symptoms related to Thrombotic Thrombocytopenic Purpura:


tremor, fever

MGI Mouse Phenotypes related to Thrombotic Thrombocytopenic Purpura:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.01 CD46 CFH F3 SELE SELP THBD
2 hematopoietic system MP:0005397 9.97 ADAMTS13 CFH F3 SELE SELP THBD
3 homeostasis/metabolism MP:0005376 9.97 ADAMTS13 APOH CFH F3 SELE SELP
4 immune system MP:0005387 9.86 ADAMTS13 CFH F3 SELE SELP THBD
5 mortality/aging MP:0010768 9.81 ADAMTS13 APOH CFH F3 SELE SELP
6 respiratory system MP:0005388 9.35 F3 SELE SELP THBD THBS1
7 vision/eye MP:0005391 9.17 ADAMTS13 CD46 CFH F3 SELE SELP
Sources

Drugs & Therapeutics for Thrombotic Thrombocytopenic Purpura

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PubMedHealth treatment related to Thrombotic Thrombocytopenic Purpura: 63

Thrombotic thrombocytopenic purpura (TTP) can be fatal or cause lasting damage, such as brain damage or a stroke, if it's not treated right away.In most cases, TTP occurs suddenly and lasts for days or weeks, but it can go on for months. Relapses (flareups) can occur in up to 60 percent of people who have acquired TTP. Flareups also occur in most people who have inherited TTP.Plasma treatments are the most common way to treat TTP. Other treatments include medicines and surgery. Treatments are done in a hospital.

Drugs for Thrombotic Thrombocytopenic Purpura (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
rituximab Approved Phase 4,Phase 3,Phase 2,Phase 1 174722-31-7 10201696
2
Clopidogrel Approved Phase 4,Phase 3 113665-84-2, 120202-66-6 60606
3
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
4 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
5 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
6 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3
7 Prasugrel hydrochloride Phase 4 389574-19-0
8 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
9 Platelet Aggregation Inhibitors Phase 4,Phase 3
10 Cytochrome P-450 CYP2C19 Inhibitors Phase 4,Phase 3
11 Purinergic P2Y Receptor Antagonists Phase 4,Phase 3
12 Fibrinolytic Agents Phase 4,Phase 3
13 Purinergic P2 Receptor Antagonists Phase 4,Phase 3
14
Prednisone Approved, Vet_approved Phase 3,Phase 2 53-03-2 5865
15
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
16
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189
17
Tacrolimus Approved, Investigational Phase 2, Phase 3,Not Applicable 104987-11-3 445643 439492
18
Sirolimus Approved, Investigational Phase 2, Phase 3 53123-88-9 46835353 6436030 5284616
19
Everolimus Approved Phase 2, Phase 3 159351-69-6 6442177
20
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 3 7487-88-9 24083
21
Dipyridamole Approved Phase 3 58-32-2 3108
22 Antineoplastic Agents, Hormonal Phase 3,Phase 2
23 Hormones Phase 3,Phase 2
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
25 Calcineurin Inhibitors Phase 3,Phase 2,Not Applicable
26 Anti-Inflammatory Agents Phase 3,Phase 2
27 Hormone Antagonists Phase 3,Phase 2
28 Cyclosporins Phase 3
29 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
30 Antifungal Agents Phase 3,Phase 2
31 Anti-Infective Agents Phase 3,Phase 2,Not Applicable
32 glucocorticoids Phase 3,Phase 2
33 Dermatologic Agents Phase 3,Not Applicable
34 Anti-Bacterial Agents Phase 2, Phase 3,Not Applicable
35 Antibiotics, Antitubercular Phase 2, Phase 3,Not Applicable
36 Peripheral Nervous System Agents Phase 3,Phase 2
37 Anticonvulsants Phase 3
38 calcium channel blockers Phase 3
39 Calcium, Dietary Phase 3
40 Anesthetics Phase 3
41 Analgesics Phase 3
42 Central Nervous System Depressants Phase 3
43 Tocolytic Agents Phase 3
44 Anti-Arrhythmia Agents Phase 3
45 Antipyretics Phase 3
46 Anti-Inflammatory Agents, Non-Steroidal Phase 3
47 Analgesics, Non-Narcotic Phase 3
48 Aspirin, Dipyridamole Drug Combination Phase 3
49 Cyclooxygenase Inhibitors Phase 3
50
Diphenhydramine Approved, Investigational Phase 2 147-24-0, 58-73-1 3100

Interventional clinical trials:

(show all 44)
# Name Status NCT ID Phase Drugs
1 Study of the Influence of Plasma Exchange on the Pharmacokinetics of Rituximab Completed NCT00820469 Phase 4 Rituximab 375;rituximab 1000
2 VERifynow in DIabetes Non-responsiveness: a Study on Switching From Clopidogrel to Prasugrel Completed NCT01684813 Phase 4 Prasugrel.;Clopidogrel
3 Prophylactic Plasma Infusion Therapy for Congenital Thrombotic Thrombocytopenic Purpura Withdrawn NCT01754545 Phase 4 Octaplas infusion and placebo (group 1);Octaplas infusion and placebo (group 2)
4 Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in Thrombotic Thrombocytopenic Purpura (TTP) Completed NCT00713193 Phase 3 Cyclosporine;Prednisone
5 Phase III Trial With Caplacizumab in Patients With Acquired Thrombotic Thrombocytopenic Purpura Completed NCT02553317 Phase 3
6 A Phase 3, Randomized, Controlled Study of Prophylactic and On-demand Treatment of cTTP With BAX 930 (rADAMTS13) Active, not recruiting NCT03393975 Phase 3
7 Follow-up Study for Patients Who Completed Study ALX0681-C301 (Post-HERCULES) Active, not recruiting NCT02878603 Phase 3
8 Magnesium Sulfate in Thrombotic Thrombocytopenic Purpura in Intensive Care Not yet recruiting NCT03237819 Phase 3 Sulfate, Magnesium;Placebo - Concentrate
9 Safety and Efficacy Study to Compare Uniplas With Cryosupernatant Plasma in Thrombotic Thrombocytopenic Purpura (TTP) Terminated NCT00411801 Phase 3
10 Evaluating the Effectiveness of Adding Rituximab to Standard Treatment for Thrombotic Thrombocytopenic Purpura (TTP) Terminated NCT00799773 Phase 3 Rituximab;Corticosteroids
11 Triple Antiplatelets for Reducing Dependency After Ischaemic Stroke Terminated NCT01661322 Phase 3 Aspirin, Dipyradimole, Clopidogrel
12 Prevention of the Graft-Versus-Host-Disease in Patients After Stem Cell Transplantation With Tacrolimus and Everolimus Terminated NCT00117702 Phase 2, Phase 3 Tacrolimus;Everolimus
13 The Use of Rituximab in Acute Thrombotic Thrombocytopenic Purpura (TTP) Unknown status NCT00937131 Phase 2 Rituximab
14 Rituximab in Patients With Relapsed or Refractory TTP-HUS Unknown status NCT00531089 Phase 2 Rituximab
15 A Single-center Clinical Trial of Bortezomib in Management of Immune Thrombocytopenia (ITP) Unknown status NCT03013114 Phase 2 Bortezomib
16 Study to Assess Efficacy and Safety of Anti-von Willebrand Factor Nanobody in Patients With Acquired Thrombotic Thrombocytopenic Purpura (TTP) Completed NCT01151423 Phase 2
17 Rituximab in Adult Acquired Idiopathic Thrombotic Thrombocytopenic Purpura Completed NCT00907751 Phase 2 rituximab
18 Thalidomide and Temozolomide or Camptothecin-11 (CPT-11) in Patients With Gliomas Completed NCT00412542 Phase 2 Thalidomide;CPT-11
19 Vinorelbine Tartrate and Cyclophosphamide in Combination With Bevacizumab or Temsirolimus in Treating Patients With Recurrent or Refractory Rhabdomyosarcoma Completed NCT01222715 Phase 2 Cyclophosphamide;Temsirolimus;Vinorelbine Tartrate
20 An Open-label Safety Study of S-888711 Completed NCT01129024 Phase 2 S-888711 0.5 mg tablet
21 Ixazomib and Dexamethasone Versus Ixazomib, Dexamethasone and Lenalidomide, Randomized With NFKB2 Rearrangement Recruiting NCT02765854 Phase 2 Dexamethasone;Ixazomib;Lenalidomide
22 Low Dose Rituximab in Thrombotic Thrombocytopenic Purpura Active, not recruiting NCT01554514 Phase 2
23 Safety Study of Danazol With Plasma Exchange and Steroids for the Treatment of Thrombotic Thrombocytopenic Purpura (TTP) Terminated NCT00953771 Phase 2 Danazol
24 IdeS in Asymptomatic Asymptomatic Antibody-Mediated Thrombotic Thrombocytopenic Purpura (TTP) Patients Terminated NCT02854059 Phase 1, Phase 2
25 Clinical Outcome Study of ARC1779 Injection in Patients With Thrombotic Microangiopathy Terminated NCT00726544 Phase 2 ARC 1779 Placebo;ARC1779 Injection;ARC1779 Injection;ARC1779 Injection
26 A Study to Investigate the Efficacy and Safety of S-888711 Tablets Administered to Adult Subjects With Immune Thrombocytopenia (ITP) Terminated NCT01054443 Phase 2 placebo to S-888711;S-888711;S-888711;S-888711
27 Use of Rituximab Treatment in Addition to Standard Care for Newly Presenting Thrombotic Thrombocytopenic Purpura Withdrawn NCT00251277 Phase 1, Phase 2 Rituximab
28 Phase 1 Dose Escalation, Single Dose Study to Assess Safety and Pharmacokinetics of BAX930 in Hereditary Thrombotic Thrombocytopenic Purpura (TTP) Completed NCT02216084 Phase 1 Recombinant ADAMTS13
29 Influence of Extracorporeal Circulation During Cardiac Surgery on the Development of Postoperative Thrombotic Thrombocytopenic Purpura (TTP) Unknown status NCT01300117
30 Levels of Von Willebrand Factor Multimers and VWF-Cleaving Protease (ADAMTS-13) in Preterm and Neonate Unknown status NCT00701610
31 ADAMTS13 in Thrombotic Thrombocytopenic Purpura Completed NCT00426686
32 Early Predictive Factors of Cardiac and Cerebral Involvement in TMA Completed NCT02134171 Not Applicable
33 Promising Bimarker Prediction of Outcome of HELLP Syndrome. Completed NCT03246542
34 European Safety Registry in Ulcerative Colitis (P04808) Completed NCT00705484 Standard Therapy
35 Tacrolimus and Mycophenolate Mofetil (MMF) in GVHD Prophylactic Regimen Compared to Tacrolimus and Methotrexate (MTX Completed NCT00360685 Not Applicable Tac+MTX;TAC + MMF
36 Prospective Psychometric Evaluation Study of a Patient-reported Outcomes (PRO) Instrument for Congenital Thrombotic Thrombocytopenic Purpura (cTTP, Upshaw-Schulman Syndrome [USS], Hereditary Thrombotic Thrombocytopenic Purpura [hTTP] Recruiting NCT03519672
37 Genotype and Phenotype Correlation in Hereditary Thrombotic Thrombocytopenic Purpura (Upshaw-Schulman Syndrome) Recruiting NCT01257269
38 Octaplas Adult TTP Trial Recruiting NCT01938404 Standard Plasma
39 TTP and aHUS in Complicated Pregnancies Recruiting NCT03605511
40 Observational Study of the Use of octaplasLG®. Recruiting NCT03369314 octaplasLG®
41 A Prospective Study on the Long-Term Vascular Burden in TTP Patients Recruiting NCT03187652
42 Natural History Study of SCID Disorders Recruiting NCT01186913
43 The Role of Microparticles as a Biomarker Enrolling by invitation NCT02626663
44 International Registry and Biorepository for TMA(Thrombotic Microangiopathy) Terminated NCT00593229

Search NIH Clinical Center for Thrombotic Thrombocytopenic Purpura

Cochrane evidence based reviews: purpura, thrombotic thrombocytopenic

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Genetic Tests for Thrombotic Thrombocytopenic Purpura

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Genetic tests related to Thrombotic Thrombocytopenic Purpura:

# Genetic test Affiliating Genes
1 Thrombotic Thrombocytopenic Purpura 29
Sources

Anatomical Context for Thrombotic Thrombocytopenic Purpura

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MalaCards organs/tissues related to Thrombotic Thrombocytopenic Purpura:

41
Kidney, Brain, Heart, Skin, Bone, Liver, Bone Marrow
Sources

Publications for Thrombotic Thrombocytopenic Purpura

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Articles related to Thrombotic Thrombocytopenic Purpura:

(show top 50) (show all 1256)
# Title Authors Year
1
Acquired thrombotic thrombocytopenic purpura with isolated CFHR3/1 deletion-rapid remission following complement blockade. ( 29728803 )
2018
2
Insights into 3D Structure of ADAMTS13: A Stepping Stone towards Novel Therapeutic Treatment of Thrombotic Thrombocytopenic Purpura. ( 29304523 )
2018
3
Inherited thrombotic thrombocytopenic purpura mimicking immune thrombocytopenic purpura during pregnancy: a case report. ( 29357939 )
2018
4
The clinical features of cardiac involvement in patients with severe thrombotic thrombocytopenic purpura. ( 29752524 )
2018
5
Pediatric thrombotic thrombocytopenic purpura. ( 29889319 )
2018
6
Child-onset thrombotic thrombocytopenic purpura caused by p.R498C and p.G259PfsX133 mutations in ADAMTS13. ( 29763513 )
2018
7
Large vessel stroke as initial presentation of thrombotic thrombocytopenic purpura. ( 29437728 )
2018
8
ADAMTS13 Testing Methodologies and Thrombotic Thrombocytopenic Purpura (TTP): Conflicting Results Can Pose a Clinical Dilemma. ( 29970443 )
2018
9
Post-Partum Thrombotic Thrombocytopenic Purpura (TTP) in a Patient with known Idiopathic (Immune) Thrombocytopenic Purpura: a case report and review of the literature. ( 29855343 )
2018
10
An open conformation of ADAMTS-13 is a hallmark of acute acquired thrombotic thrombocytopenic purpura. ( 29222940 )
2018
11
Concurrent Presentation of Thrombotic Thrombocytopenic Purpura and Membranous Nephropathy. ( 29725652 )
2018
12
Pathophysiology of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. ( 29356300 )
2018
13
Ticagrelor-induced thrombotic thrombocytopenic purpura: A case report and review of the literature. ( 29952973 )
2018
14
Myocardial Infarction as an Early Presentation in Thrombotic Thrombocytopenic Purpura: A Rare Case Series. ( 29761111 )
2018
15
Changes in plasma von Willebrand factor and von Willebrand factor cleaving protease in thrombotic thrombocytopenic purpura: A case report. ( 29250148 )
2018
16
Intravenous immunoglobulin as salvage therapy for refractory thrombotic thrombocytopenic purpura. ( 29247542 )
2018
17
The Diagnostic Challenge of Acquired Thrombotic Thrombocytopenic Purpura in Children: Case Report and Review of the Literature. ( 29659973 )
2018
18
Neuro-Behcet's disease in a patient with thrombotic thrombocytopenic purpura. ( 29444324 )
2018
19
Does this patient with thrombotic thrombocytopenic purpura have a cardiac involvement? ( 29868970 )
2018
20
No major differences in outcomes between the initial and relapse episodes in patients with thrombotic thrombocytopenic purpura: The experience from the Ohio State University Registry. ( 29226481 )
2018
21
Schistocytosis occurs in severely anemic B12-deficient patients and does not imply thrombotic thrombocytopenic purpura. ( 29790646 )
2018
22
Relapsed/refractory thrombotic thrombocytopenic purpura treated with N-acetylcysteine: a case report. ( 29739267 )
2018
23
Nurses best practices for the management of thrombotic thrombocytopenic purpura. ( 29960714 )
2018
24
Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers. ( 29674502 )
2018
25
Characterization of efficacy and safety of pathogen inactivated and quarantine plasma in routine use for treatment of acquired immune thrombotic thrombocytopenic purpura. ( 29786866 )
2018
26
The utility of a fast turnaround ADAMTS13 activity in the diagnosis and exclusion of thrombotic thrombocytopenic purpura. ( 29687882 )
2018
27
Vincristine as an Adjunct to Therapeutic Plasma Exchange for Thrombotic Thrombocytopenic Purpura: A Single Institution Experience. ( 29966997 )
2018
28
The remarkable diversity of thrombotic thrombocytopenic purpura: a perspective. ( 29945940 )
2018
29
Bone Marrow Necrosis in Sickle Cell-Beta Thalassemia Patient Mimicking Thrombotic Thrombocytopenic Purpura. ( 30373875 )
2018
30
Fat Embolism Syndrome due to Bone Marrow Necrosis in Patients with Hemoglobinopathies: A Life-threatening Complication Mimicking Thrombotic Thrombocytopenic Purpura. ( 30479040 )
2018
31
Ehrlichiosis masquerading as thrombotic thrombocytopenic purpura. ( 30279260 )
2018
32
Thrombotic thrombocytopenic purpura-like syndrome associated with arcanobacterium pyogenes endocarditis in a post-transplant patient: A case report. ( 30350823 )
2018
33
Treatment of Concurrent Thrombotic Thrombocytopenic Purpura and Graves' Disease: A Report on Two Cases. ( 30159177 )
2018
34
Interferon beta-1b-induced thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS) in a patient treated for multiple sclerosis: A case report. ( 30210736 )
2018
35
No More Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndrome Please. ( 30367852 )
2018
36
Thrombotic thrombocytopenic purpura and hemophagocytic lymphohistiocytosis in an elderly man: A case report. ( 30383662 )
2018
37
Thrombotic thrombocytopenic purpura as the first presentation in systemic lupus erythematosus. ( 30237633 )
2018
38
Comment on the article by Opeyemi Folorunsho Bamidele, Richard Oluyinka Akintayo, Mathew Olumuyiwa Bojuwoye, et al. "Thrombotic thrombocytopenic purpura as the first presentation in systemic lupus erythematosus". ( 30237634 )
2018
39
A Rare Case of Thrombotic Thrombocytopenic Purpura Caused by Pancreatitis and Clopidogrel. ( 30374015 )
2018
40
Complement Regulatory Genetic Mutations in the Setting of Autoimmune Thrombotic Thrombocytopenic Purpura: A Case Series. ( 30225434 )
2018
41
Relapse Rate in Survivors of Acute Autoimmune Thrombotic Thrombocytopenic Purpura Treated with or without Rituximab. ( 30235478 )
2018
42
Anti-ADAMTS13 Autoantibodies against Cryptic Epitopes in Immune-Mediated Thrombotic Thrombocytopenic Purpura. ( 30235483 )
2018
43
Clinical presentation in thrombotic thrombocytopenic purpura: Real-world data from two Mexican institutions. ( 30321453 )
2018
44
Validation of the PLASMIC score, a clinical prediction tool for thrombotic thrombocytopenic purpura diagnosis, in Chinese patients. ( 30340093 )
2018
45
Transfusion of Platelets Loaded With Recombinant ADAMTS13 (A Disintegrin and Metalloprotease With Thrombospondin Type 1 Repeats-13) Is Efficacious for Inhibiting Arterial Thrombosis Associated With Thrombotic Thrombocytopenic Purpura. ( 30354235 )
2018
46
Relapsed/refractory acquired thrombotic thrombocytopenic purpura in a patient with Sjögren syndrome: Case report and review of the literature. ( 30412131 )
2018
47
Postoperative Thrombotic Thrombocytopenic Purpura after Total Hip Arthroplasty: A Case Report and Review of the Literature. ( 30425874 )
2018
48
Multidisciplinary team approach for an atypical presentation of postpartum thrombotic thrombocytopenic purpura and severe preeclampsia in the Intensive Care Unit. ( 30429751 )
2018
49
Link between von Willebrand factor multimers, relapses and coronary microcirculation in patients with thrombotic thrombocytopenic purpura in remission. ( 30471507 )
2018
50
Pharmacokinetics of plasma infusion in congenital thrombotic thrombocytopenic purpura. ( 30475428 )
2018
Sources

Variations for Thrombotic Thrombocytopenic Purpura

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ClinVar genetic disease variations for Thrombotic Thrombocytopenic Purpura:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 ADAMTS13 NM_139025.4(ADAMTS13): c.3541G> A (p.Gly1181Arg) single nucleotide variant Pathogenic rs192619276 GRCh37 Chromosome 9, 136320698: 136320698
2 ADAMTS13 NM_139025.4(ADAMTS13): c.3541G> A (p.Gly1181Arg) single nucleotide variant Pathogenic rs192619276 GRCh38 Chromosome 9, 133455576: 133455576
3 ADAMTS13 NM_139025.4(ADAMTS13): c.581G> T (p.Gly194Val) single nucleotide variant Pathogenic GRCh37 Chromosome 9, 136291360: 136291360
4 ADAMTS13 NM_139025.4(ADAMTS13): c.581G> T (p.Gly194Val) single nucleotide variant Pathogenic GRCh38 Chromosome 9, 133426240: 133426240
5 ADAMTS13 NM_139025.4(ADAMTS13): c.2209T> C (p.Cys737Arg) single nucleotide variant Pathogenic GRCh38 Chromosome 9, 133442718: 133442718
6 ADAMTS13 NM_139025.4(ADAMTS13): c.2209T> C (p.Cys737Arg) single nucleotide variant Pathogenic GRCh37 Chromosome 9, 136307839: 136307839
Sources

Expression for Thrombotic Thrombocytopenic Purpura

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Search GEO for disease gene expression data for Thrombotic Thrombocytopenic Purpura.
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Pathways for Thrombotic Thrombocytopenic Purpura

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Pathways related to Thrombotic Thrombocytopenic Purpura according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.58 APOH F3 SELE SELP THBD THBS1
2
O-linked glycosylation 66
Show member pathways
 11.92 ADAMTS13 ADAMTSL1 THBS1
3
Cell surface interactions at the vascular wall 66
Show member pathways
 11.89 SELE SELP THBD
4
Formation of Fibrin Clot (Clotting Cascade) 66
Show member pathways
 11.81 F3 THBD VWF
5
Diseases of glycosylation 66
Show member pathways
 11.74 ADAMTS13 ADAMTSL1 THBS1
6
AGE-RAGE signaling pathway in diabetic complications 37
11.54 F3 SELE THBD
7
Angiogenesis (CST) 4
11.45 F3 THBS1 VWF
8
O-glycosylation of TSR domain-containing proteins 66
Show member pathways
 11.31 ADAMTS13 ADAMTSL1 THBS1
9
Complement and coagulation cascades 1 37
11.16 CD46 CFH F3 THBD VWF
10
Malaria 37
11.02 SELE SELP THBS1
Sources

GO Terms for Thrombotic Thrombocytopenic Purpura

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Cellular components related to Thrombotic Thrombocytopenic Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ADAMTS13 ADAMTSL1 APOH CFH F3 THBS1
2 extracellular space GO:0005615 9.56 ADAMTS13 APOH CFH F3 SELE SELP
3 collagen-containing extracellular matrix GO:0062023 9.46 APOH F3 THBS1 VWF
4 platelet alpha granule GO:0031091 9.32 THBS1 VWF
5 cell surface GO:0009986 9.1 ADAMTS13 APOH CD46 F3 THBD THBS1

Biological processes related to Thrombotic Thrombocytopenic Purpura according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.84 SELE SELP THBS1 VWF
2 response to lipopolysaccharide GO:0032496 9.67 SELE SELP THBD
3 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 9.56 SELE SELP
4 blood coagulation GO:0007596 9.56 ADAMTS13 F3 THBD VWF
5 negative regulation of endothelial cell proliferation GO:0001937 9.55 APOH THBS1
6 response to tumor necrosis factor GO:0034612 9.52 ADAMTS13 SELE
7 leukocyte cell-cell adhesion GO:0007159 9.51 SELE SELP
8 negative regulation of endothelial cell migration GO:0010596 9.48 APOH THBS1
9 leukocyte tethering or rolling GO:0050901 9.46 SELE SELP
10 platelet degranulation GO:0002576 9.46 APOH SELP THBS1 VWF
11 blood coagulation, intrinsic pathway GO:0007597 9.43 APOH VWF
12 negative regulation of blood coagulation GO:0030195 9.4 APOH THBD
13 positive regulation of blood coagulation GO:0030194 9.37 APOH THBS1
14 positive regulation of transforming growth factor beta production GO:0071636 9.32 CD46 THBS1
15 negative regulation of fibrinolysis GO:0051918 9.13 APOH THBD THBS1
16 hemostasis GO:0007599 8.92 ADAMTS13 F3 THBD VWF

Molecular functions related to Thrombotic Thrombocytopenic Purpura according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.62 ADAMTS13 SELP THBD THBS1
2 integrin binding GO:0005178 9.43 ADAMTS13 THBS1 VWF
3 oligosaccharide binding GO:0070492 9.16 SELE SELP
4 sialic acid binding GO:0033691 8.96 SELE SELP
5 heparin binding GO:0008201 8.92 APOH CFH SELP THBS1
Sources

Sources for Thrombotic Thrombocytopenic Purpura

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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