MCID: THY042
MIFTS: 27

Thymic Epithelial Tumor

Categories: Rare diseases

Aliases & Classifications for Thymic Epithelial Tumor

MalaCards integrated aliases for Thymic Epithelial Tumor:

Name: Thymic Epithelial Tumor 53 72
Epithelial Tumor of Thymus 53
Thymoma, Adult 53

Classifications:



External Ids:

UMLS 72 C1266101

Summaries for Thymic Epithelial Tumor

MalaCards based summary : Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and mediastinal cancer. An important gene associated with Thymic Epithelial Tumor is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Pembrolizumab and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include thymus, bone and bone marrow.

Related Diseases for Thymic Epithelial Tumor

Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 85)
# Related Disease Score Top Affiliating Genes
1 thymoma 30.8 KIT CD5
2 mediastinal cancer 29.6 KIT CD5
3 mixed type thymoma 29.5 KIT CD5
4 thymoma, familial 11.8
5 thymic epithelial neoplasm 11.8
6 thymoma type b 11.7
7 thymoma type a 11.4
8 thymoma type ab 11.4
9 thymic carcinoma 10.9
10 myasthenia gravis 10.7
11 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
12 neutropenia 10.3
13 epithelial malignant thymoma 10.3
14 autoimmune disease 10.2
15 cortical thymoma 10.2
16 paraneoplastic syndromes 10.2
17 neuroendocrine tumor 10.1
18 dendritic cell thymoma 10.1
19 thymus squamous cell carcinoma 10.1
20 lung cancer 10.0
21 gastrointestinal stromal tumor 10.0
22 good syndrome 10.0
23 hemopericardium 10.0
24 pericardial effusion 10.0
25 neuroendocrine carcinoma 10.0
26 glomerulonephritis 10.0
27 seminoma 10.0
28 type c thymoma 10.0
29 thyroiditis 10.0
30 pulmonary vein stenosis 9.9 KIT CD99
31 burkitt lymphoma 9.9
32 carcinoid tumors, intestinal 9.9
33 retinoblastoma 9.9
34 sarcoidosis 1 9.9
35 small cell cancer of the lung 9.9
36 sjogren syndrome 9.9
37 myelodysplastic syndrome 9.9
38 spastic paraplegia, intellectual disability, nystagmus, and obesity 9.9
39 small cell carcinoma 9.9
40 lymphoma 9.9
41 chronic leukemia 9.9
42 acute leukemia 9.9
43 pure red-cell aplasia 9.9
44 adult-onset still's disease 9.9
45 pleural disease 9.9
46 thrombocytopenia 9.9
47 malignant fibroxanthoma 9.9
48 melanoma 9.9
49 myeloproliferative neoplasm 9.9
50 benign mesothelioma 9.9

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to Thymic Epithelial Tumor

Symptoms & Phenotypes for Thymic Epithelial Tumor

Drugs & Therapeutics for Thymic Epithelial Tumor

Drugs for Thymic Epithelial Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
3
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5 Antineoplastic Agents, Immunological Phase 2
6 Antineoplastic Agents, Phytogenic Phase 2
7 Tubulin Modulators Phase 2
8 Albumin-Bound Paclitaxel Phase 2
9 Antimitotic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Pembrolizumab for Patients With Thymic Epithelial Tumor Who Progressed After at Least One Previous Regimen of Cisplatin-Containing Chemotherapy Unknown status NCT02607631 Phase 2 Pembrolizumab
2 A Phase 2, Open-label Study of Selinexor (KPT-330) in Patients With Advanced Thymic Epithelial Tumor (TET) Progressing After Primary Chemotherapy (SELECT) Recruiting NCT03193437 Phase 2 Open Label Selinexor
3 A Phase II, Neo-adjuvant Pembrolizumab, Docetaxel, Cisplatin Therapy Followed by Surgery and Pembrolizumab Consolidation Therapy in Locally Advanced Thymic Epithelial Tumor (TET) Not yet recruiting NCT03858582 Phase 2 pembrolizumab
4 A Phase II Study of Paclitaxel and Cisplatin in Previously Untreated, Unresectable Invasive Thymoma or Thymic Carcinoma Terminated NCT00818090 Phase 2 paclitaxel and cisplatin
5 Preoperative Prediction of the Pathological Classification of Thymic Epithelial Tumors by Apparent Diffusion Coefficient Using Ultra-high B-values Unknown status NCT03212027
6 French National Observatory of Patients With Thymic Epithelial Tumor Recruiting NCT02724696
7 Inpatient Hospice With Procurement of Tissue on Expiration in Thoracic Malignancies, Bladder Cancer, and Patients Treated With an Adoptive Cellular Therapy Recruiting NCT01851395

Search NIH Clinical Center for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

Anatomical Context for Thymic Epithelial Tumor

MalaCards organs/tissues related to Thymic Epithelial Tumor:

41
Thymus, Bone, Bone Marrow, Breast, Heart, T Cells

Publications for Thymic Epithelial Tumor

Articles related to Thymic Epithelial Tumor:

(show top 50) (show all 81)
# Title Authors PMID Year
1
Pembrolizumab for Patients With Refractory or Relapsed Thymic Epithelial Tumor: An Open-Label Phase II Trial. 38
29906252 2019
2
Thymic epithelial tumor complicated by immunological abnormalities: results from a single-center retrospective study in China. 38
31179102 2019
3
Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature. 38
30961527 2019
4
Analysis of surgical treatment of Masaoka stage III-IV thymic epithelial tumors. 38
30132223 2018
5
Patterns of Failure Following Postoperative Radiation Therapy Based on "Tumor Bed With Margin" for Stage II to IV Type C Thymic Epithelial Tumor. 38
30099130 2018
6
Successful Use of Pembrolizumab to Treat Refractory Thymic Carcinoma with High PD-L1 Expression. 38
30483099 2018
7
Usefulness of Volume Perfusion Computed Tomography in Differentiating Histologic Subtypes of Thymic Epithelial Tumors. 38
29553964 2018
8
Diagnosis of thymic epithelial tumor subtypes by a quantitative proteomic approach. 38
29645059 2018
9
A Clinical Observation of Thymic Epithelial Tumor Metastatic to Breast. 38
29887792 2018
10
Focal adhesion kinase is overexpressed in thymic epithelial tumors and may serve as an independent prognostic biomarker. 38
29435030 2018
11
Incidental Anterior Mediastinal Nodular Lesions on Chest CT in Asymptomatic Subjects. 38
29233791 2018
12
Comparison of Interobserver Agreement and Diagnostic Accuracy for IASLC/ITMIG Thymic Epithelial Tumor Staging Among Co-registered FDG-PET/MRI, Whole-body MRI, Integrated FDG-PET/CT, and Conventional Imaging Examination with and without Contrast Media Administrations. 38
29395795 2018
13
Dedifferentiated primary mediastinal liposarcoma mimicking a thymic tumor. 38
29449733 2017
14
JLCS medical practice guidelines for thymic tumors: summary of recommendations. 38
29036455 2017
15
Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors. 38
28819023 2017
16
Antineutrophil Cytoplasmic Antibody-Associated Rapid Progressive Glomerulonephritis after Pembrolizumab Treatment in Thymic Epithelial Tumor: A Case Report. 38
28342816 2017
17
Quantitative computed tomography texture analysis for estimating histological subtypes of thymic epithelial tumors. 38
28624025 2017
18
Thymic Hyperplasia after Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. 38
27865872 2017
19
A Rare Tumor with a Very Rare Initial Presentation: Thymic Carcinoma as Bone Marrow Metastasis. 38
28116199 2017
20
An unusual combined thymic carcinoma composed of squamous cell carcinoma and type AB thymoma: a rare case report. 38
28095872 2017
21
Thymoma Metastasis to the Semimembranosus Muscle. 38
28203162 2017
22
Value of volume-based early metabolic response in patients with unresectable thymic epithelial tumor. 38
27597277 2016
23
Robotic Thymectomy in Anterior Mediastinal Mass: Propensity Score Matching Study With Transsternal Thymectomy. 38
27234580 2016
24
Occasional detection of thymic epithelial tumor 4 years after diagnosis of adult onset Still disease: A challenging case report and immuno-oncological considerations coming from pertinent literature review. 38
27603335 2016
25
Trends and current status of general thoracic surgery in Japan revealed by review of nationwide databases. 38
27651932 2016
26
Differentiating the grades of thymic epithelial tumor malignancy using textural features of intratumoral heterogeneity via (18)F-FDG PET/CT. 38
26868139 2016
27
Thymic Epithelial Tumor-Associated Cytopenia: A 10-Year Observational Study in France. 38
26768832 2016
28
Rare frequency of gene variation and survival analysis in thymic epithelial tumors. 38
27789964 2016
29
[Management for Life-threatening Mediastinal Tumor]. 38
26197918 2015
30
Perplexing histologic classification of thymic epithelial tumor. 38
25997137 2015
31
Diffuse high intensity PD-L1 staining in thymic epithelial tumors. 38
25402569 2015
32
Establishment and characterization of a novel cell line derived from thymoma with myasthenia gravis patients. 38
26273358 2015
33
Thymic epithelial tumors: prognostic determinants among clinical, histopathologic, and computed tomography findings. 38
25534526 2015
34
[Diaphragmatic hernia complicated with diaphragmatic resection by automatic stapling device]. 38
25292370 2014
35
The presence of extrathoracic metastasis is more prognostic of survival than Masaoka stage (IVa/IVb) in metastatic thymic epithelial tumor: a retrospective cohort study. 38
24954359 2014
36
Prognostic factors of patients with thymic carcinoma after surgery: a retrospective analysis of 58 cases. 38
24615610 2014
37
[Diagnosis and differential diagnosis of thymic epithelial tumor]. 38
25327807 2014
38
[Research status of molecular targeted therapy in thymic epithelial tumors]. 38
24949690 2014
39
Primary papillary carcinoma of the thymus with invasion into subcutaneous tissue through the sternum. 38
24885502 2014
40
¹⁸F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms. 38
24173608 2014
41
Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature. 38
24444077 2014
42
Imaging of a case of metaplastic thymoma on 18F-FDG PET/CT. 38
24212449 2013
43
Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor. 38
23695010 2013
44
STAT3 expression correlates with prognosis of thymic epithelial tumors. 38
23590999 2013
45
Usefulness of fluorine-18 fluorodeoxyglucose-positron emission tomography in management strategy for thymic epithelial tumors. 38
23200236 2013
46
Expression of thymidylate synthase and orotate phosphoribosyltransferase in thymic carcinoma. 38
23170110 2012
47
Is There a Role of Postoperative Radiation Therapy in Completely Resected Stage I/II Thymic Epithelial Tumor? 38
23091442 2012
48
[Multilocular thymic cyst associated with rheumatoid arthritis]. 38
22374595 2012
49
Metaplastic thymoma of the mediastinum. A clinicopathologic, immunohistochemical, and genetic analysis. 38
22261452 2012
50
¹⁸F-FDG uptake on PET could be a predictive marker of excision repair cross-complementation group 1 (ERCC1) expression in patients with thoracic neoplasms? 38
22329847 2012

Variations for Thymic Epithelial Tumor

Expression for Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for Thymic Epithelial Tumor

Pathways related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 KIT CD5
2 10.94 KIT CD5
3 10.35 KIT CD5

GO Terms for Thymic Epithelial Tumor

Cellular components related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 KIT CD5
2 integral component of plasma membrane GO:0005887 8.8 KIT CD99 CD5

Molecular functions related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.32 CD5

Sources for Thymic Epithelial Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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