MCID: THY042
MIFTS: 26

Thymic Epithelial Tumor

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Thymic Epithelial Tumor

MalaCards integrated aliases for Thymic Epithelial Tumor:

Name: Thymic Epithelial Tumor 20 71
Epithelial Tumor of Thymus 20
Thymoma, Adult 20

Classifications:



External Ids:

UMLS 71 C1266101

Summaries for Thymic Epithelial Tumor

MalaCards based summary : Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and thymic carcinoma. An important gene associated with Thymic Epithelial Tumor is CD5 (CD5 Molecule), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs ramucirumab and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Thymic Epithelial Tumor

Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 thymoma 30.7 KIT CD5
2 thymic carcinoma 30.7 KIT CD5
3 thymic epithelial neoplasm 11.3
4 thymoma, familial 11.3
5 thymoma type a 11.2
6 thymoma type b 11.2
7 thymoma type ab 11.2
8 myasthenia gravis 10.3
9 autoimmune disease 10.2
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.1
11 good syndrome 10.1
12 neuroendocrine carcinoma 10.1
13 glomerulonephritis 10.1
14 thyroiditis 10.1
15 rare tumor 10.0
16 spindle epithelial tumor with thymus-like differentiation tumor 10.0 KIT CD5
17 lymphoepithelioma-like thymic carcinoma 10.0 KIT CD5
18 type c thymoma 9.9 KIT CD5
19 thymus clear cell carcinoma 9.9 KIT CD5
20 mediastinal cancer 9.9 KIT CD5
21 sarcoidosis 1 9.9
22 sjogren syndrome 9.9
23 small cell carcinoma 9.9
24 pure red-cell aplasia 9.9
25 adult-onset still's disease 9.9
26 neuroendocrine tumor 9.9
27 rapidly progressive glomerulonephritis 9.9
28 fibromyalgia 9.9
29 cortical thymoma 9.9
30 epithelial malignant thymoma 9.9
31 myocarditis 9.9
32 evans' syndrome 9.9
33 pemphigus 9.9
34 47,xyy 9.9
35 myoclonus 9.9
36 thymic neuroendocrine tumor 9.9
37 red cell aplasia 9.9
38 thymus gland disease 9.9 KIT CD5
39 thymus cancer 9.9 KIT CD5
40 leukocyte disease 9.9 KIT CD5
41 pulmonary vein stenosis 9.8 KIT CD99
42 blood platelet disease 9.8 KIT CD5
43 malignant teratoma 9.8 KIT CD99
44 teratoma 9.8 KIT CD99
45 gliofibroma 9.8 KIT CD99
46 blood coagulation disease 9.8 KIT CD5
47 bladder sarcoma 9.8 KIT CD99
48 hemangiopericytoma, malignant 9.8 KIT CD99
49 synovium cancer 9.8 KIT CD99
50 pancytopenia 9.8 KIT CD5

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to Thymic Epithelial Tumor

Symptoms & Phenotypes for Thymic Epithelial Tumor

GenomeRNAi Phenotypes related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

26 (show all 17)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-10 9.55 CD99
2 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.55 CD99
3 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.55 CD99
4 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.55 KIT
5 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.55 KIT
6 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.55 KIT
7 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.55 CD99
8 Increased shRNA abundance (Z-score > 2) GR00366-A-190 9.55 CD99
9 Increased shRNA abundance (Z-score > 2) GR00366-A-213 9.55 CD99
10 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.55 KIT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.55 CD99
12 Increased shRNA abundance (Z-score > 2) GR00366-A-61 9.55 KIT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.55 CD99
14 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.55 KIT
15 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.55 KIT
16 Increased shRNA abundance (Z-score > 2) GR00366-A-91 9.55 CD99
17 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.55 KIT

Drugs & Therapeutics for Thymic Epithelial Tumor

Drugs for Thymic Epithelial Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
ramucirumab Approved, Investigational Phase 2 947687-13-0
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4
Pembrolizumab Approved Phase 2 1374853-91-4
5
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
6
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
7
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
8
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
9 Molgramostim Investigational Phase 2 99283-10-0
10 Immunoglobulins Phase 2
11 Antibodies Phase 2
12 Antineoplastic Agents, Immunological Phase 2
13 Iron-Dextran Complex Phase 2
14 Antimitotic Agents Phase 2
15 Albumin-Bound Paclitaxel Phase 2
16 Tubulin Modulators Phase 2
17
Etoposide Approved 33419-42-0 36462
18 Etoposide phosphate

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Phase II Study of Pembrolizumab for Patients With Thymic Epithelial Tumor Who Progressed After at Least One Previous Regimen of Cisplatin-Containing Chemotherapy Completed NCT02607631 Phase 2 Pembrolizumab
2 A Prospective, Phase II Trial of Induction Chemotherapy With Docetaxel/Cisplatin for Masaoka Stage III/IV Thymic Epithelial Tumors Completed NCT01312324 Phase 2 neoadjuvant docetaxel/cisplatin
3 A Phase II, Open-Label Trial of Bintrafusp Alfa (M7824) in Subjects With Thymoma and Thymic Carcinoma Recruiting NCT04417660 Phase 2 M7824
4 A Phase 2, Open-label Study of Selinexor (KPT-330) in Patients With Advanced Thymic Epithelial Tumor (TET) Progressing After Primary Chemotherapy (SELECT) Recruiting NCT03193437 Phase 2 Open Label Selinexor
5 Improving Treatment Strategies in Thymic Epithelial Tumors: a TYME Collaborative Effort Recruiting NCT03921671 Phase 2
6 Clinical Study of Neoadjuvant PD-1 Antibody (Toripalimab) Plus Chemotherapy for Locally Advanced Thymic Epithelial Tumor Not yet recruiting NCT04667793 Phase 2 Toripalimab;Chemotherapy;Chemotherapy
7 A Phase II, Neo-adjuvant Pembrolizumab, Docetaxel, Cisplatin Therapy Followed by Surgery and Pembrolizumab Consolidation Therapy in Locally Advanced Thymic Epithelial Tumor (TET) Not yet recruiting NCT03858582 Phase 2 pembrolizumab
8 Abscopal Effect of SBRT in Combination With rhGM-CSF and INF-α 2b for Metastatic Thymic Epithelial Tumors Not yet recruiting NCT04517539 Phase 2 rhGM-CSF,Peginterferon alfa-b2,radiation
9 A Phase II Study of Paclitaxel and Cisplatin in Previously Untreated, Unresectable Invasive Thymoma or Thymic Carcinoma Terminated NCT00818090 Phase 2 paclitaxel and cisplatin
10 Preoperative Prediction of the Pathological Classification of Thymic Epithelial Tumors by Apparent Diffusion Coefficient Using Ultra-high B-values Unknown status NCT03212027
11 Evaluate the Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors Completed NCT03288662
12 Phase Ⅱ Study of Concurrent Chemoradiotherapy for Limited Advanced Unresectable Thymic Epithelial Tumors Completed NCT02636556
13 French National Observatory of Patients With Thymic Epithelial Tumor Recruiting NCT02724696
14 Tissue Procurement and Natural History Study of Patients With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors Recruiting NCT02146170

Search NIH Clinical Center for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

Anatomical Context for Thymic Epithelial Tumor

MalaCards organs/tissues related to Thymic Epithelial Tumor:

40
Thymus, Lung, Bone Marrow, Neutrophil

Publications for Thymic Epithelial Tumor

Articles related to Thymic Epithelial Tumor:

(show top 50) (show all 99)
# Title Authors PMID Year
1
Comparison of PD-L1 immunohistochemical assays and the significance of PD-L1 expression in thymoma. 61
33447446 2020
2
Successful treatment of combined thymic epithelial tumor with hepatic metastasis: a long disease-free survival case. 61
32162069 2020
3
Development and validation of a CT-texture analysis nomogram for preoperatively differentiating thymic epithelial tumor histologic subtypes. 61
33308325 2020
4
Thymic metastasis of ovarian cancer 33 years after primary surgery. 61
33130116 2020
5
Extracellular volume fraction measurement correlates with lymphocyte abundance in thymic epithelial tumors. 61
33028413 2020
6
Prognostic Factor of Completely Resected and Pathologic T3 N0 M0 Thymic Epithelial Tumor. 61
32888924 2020
7
The expression pattern of ACTBL2 in thymoma reveals its potential therapeutic target efficacy. 61
33277874 2020
8
High Neutrophil Count as a Negative Prognostic Factor for Relapse in Patients with Thymic Epithelial Tumor. 61
31993857 2020
9
Thymic Small Cell Carcinoma Associated With Lambert-Eaton Myasthenic Syndrome. 61
31586614 2020
10
Thymic epithelial tumor treatment in Japan: analysis of hospital cancer registry and insurance claims data, 2012-2014. 61
31829410 2020
11
Robotic thymectomy for advanced thymic epithelial tumor: indications and technical aspects. 61
32190355 2020
12
Immune-related adverse events are clustered into distinct subtypes by T-cell profiling before and early after anti-PD-1 treatment. 61
32076579 2020
13
A mutational profile in multiple thymic squamous cell carcinoma. 61
32042677 2019
14
The change of therapeutic trends in the thymic epithelial tumor. 61
32030291 2019
15
[Multilocular Thymic Cyst with Calcification;Report of a Case]. 61
31588118 2019
16
Pembrolizumab for Patients With Refractory or Relapsed Thymic Epithelial Tumor: An Open-Label Phase II Trial. 61
29906252 2019
17
Surgical approach for thymic epithelial tumor. 61
31559082 2019
18
Thymic epithelial tumor complicated by immunological abnormalities: results from a single-center retrospective study in China. 61
31179102 2019
19
Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature. 61
30961527 2019
20
Micronodular thymoma with lymphoid stroma: report of two cases and review of literature. 61
31934213 2019
21
Immune biomarkers in thymic epithelial tumors: expression patterns, prognostic value and comparison of diagnostic tests for PD-L1. 61
31827799 2019
22
Analysis of surgical treatment of Masaoka stage III-IV thymic epithelial tumors. 61
30132223 2018
23
Patterns of Failure Following Postoperative Radiation Therapy Based on "Tumor Bed With Margin" for Stage II to IV Type C Thymic Epithelial Tumor. 61
30099130 2018
24
Successful Use of Pembrolizumab to Treat Refractory Thymic Carcinoma with High PD-L1 Expression. 61
30483099 2018
25
Usefulness of Volume Perfusion Computed Tomography in Differentiating Histologic Subtypes of Thymic Epithelial Tumors. 61
29553964 2018
26
Diagnosis of thymic epithelial tumor subtypes by a quantitative proteomic approach. 61
29645059 2018
27
A Clinical Observation of Thymic Epithelial Tumor Metastatic to Breast. 61
29887792 2018
28
Focal adhesion kinase is overexpressed in thymic epithelial tumors and may serve as an independent prognostic biomarker. 61
29435030 2018
29
Incidental Anterior Mediastinal Nodular Lesions on Chest CT in Asymptomatic Subjects. 61
29233791 2018
30
Comparison of Interobserver Agreement and Diagnostic Accuracy for IASLC/ITMIG Thymic Epithelial Tumor Staging Among Co-registered FDG-PET/MRI, Whole-body MRI, Integrated FDG-PET/CT, and Conventional Imaging Examination with and without Contrast Media Administrations. 61
29395795 2018
31
JLCS medical practice guidelines for thymic tumors: summary of recommendations. 61
29036455 2017
32
Dedifferentiated primary mediastinal liposarcoma mimicking a thymic tumor. 61
29449733 2017
33
Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors. 61
28819023 2017
34
Antineutrophil Cytoplasmic Antibody-Associated Rapid Progressive Glomerulonephritis after Pembrolizumab Treatment in Thymic Epithelial Tumor: A Case Report. 61
28342816 2017
35
Quantitative computed tomography texture analysis for estimating histological subtypes of thymic epithelial tumors. 61
28624025 2017
36
Thymic Hyperplasia after Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. 61
27865872 2017
37
A Rare Tumor with a Very Rare Initial Presentation: Thymic Carcinoma as Bone Marrow Metastasis. 61
28116199 2017
38
An unusual combined thymic carcinoma composed of squamous cell carcinoma and type AB thymoma: a rare case report. 61
28095872 2017
39
Thymoma Metastasis to the Semimembranosus Muscle. 61
28203162 2017
40
Value of volume-based early metabolic response in patients with unresectable thymic epithelial tumor. 61
27597277 2016
41
Robotic Thymectomy in Anterior Mediastinal Mass: Propensity Score Matching Study With Transsternal Thymectomy. 61
27234580 2016
42
Occasional detection of thymic epithelial tumor 4 years after diagnosis of adult onset Still disease: A challenging case report and immuno-oncological considerations coming from pertinent literature review. 61
27603335 2016
43
Trends and current status of general thoracic surgery in Japan revealed by review of nationwide databases. 61
27651932 2016
44
Differentiating the grades of thymic epithelial tumor malignancy using textural features of intratumoral heterogeneity via (18)F-FDG PET/CT. 61
26868139 2016
45
Thymic Epithelial Tumor-Associated Cytopenia: A 10-Year Observational Study in France. 61
26768832 2016
46
Rare frequency of gene variation and survival analysis in thymic epithelial tumors. 61
27789964 2016
47
[Management for Life-threatening Mediastinal Tumor]. 61
26197918 2015
48
Perplexing histologic classification of thymic epithelial tumor. 61
25997137 2015
49
Diffuse high intensity PD-L1 staining in thymic epithelial tumors. 61
25402569 2015
50
Establishment and characterization of a novel cell line derived from thymoma with myasthenia gravis patients. 61
26273358 2015

Variations for Thymic Epithelial Tumor

Expression for Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for Thymic Epithelial Tumor

Pathways related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.02 KIT CD5
2 10.62 KIT CD5

GO Terms for Thymic Epithelial Tumor

Cellular components related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 KIT CD5
2 integral component of plasma membrane GO:0005887 8.8 KIT CD99 CD5

Sources for Thymic Epithelial Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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