MCID: THY042
MIFTS: 29

Thymic Epithelial Tumor

Categories: Rare diseases

Aliases & Classifications for Thymic Epithelial Tumor

MalaCards integrated aliases for Thymic Epithelial Tumor:

Name: Thymic Epithelial Tumor 53 73
Epithelial Tumor of Thymus 53
Thymoma, Adult 53

Classifications:



External Ids:

UMLS 73 C1266101

Summaries for Thymic Epithelial Tumor

MalaCards based summary : Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymus cancer and thymoma. An important gene associated with Thymic Epithelial Tumor is KIT (KIT Proto-Oncogene Receptor Tyrosine Kinase), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Cisplatin and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include thymus, lung and heart, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Thymic Epithelial Tumor

Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 thymus cancer 29.2 CD5 KIT
2 thymoma 29.0 CD5 KIT
3 thymoma, familial 11.1
4 thymoma type a 11.1
5 thymoma type b 11.1
6 thymoma type ab 11.1
7 pulmonary vein stenosis 9.9 CD99 KIT
8 myasthenia gravis 9.9
9 myasthenia gravis congenital 9.9
10 malignant skin fibrous histiocytoma 9.8 CD99 KIT
11 malignant dermis tumor 9.8 CD99 KIT
12 connective tissue cancer 9.8 CD99 KIT
13 glomerulonephritis 9.7
14 conn's syndrome 9.7
15 cortical thymoma 9.7
16 breast cancer 9.7
17 teratoma 9.7 CD99 KIT
18 epidural neoplasm 9.6 CD5 CD99
19 mixed type thymoma 9.6 CD5 KIT
20 mediastinal cancer 9.5 CD5 KIT
21 necrotizing sialometaplasia 9.5 CD5 KIT
22 ewing sarcoma 9.2 CD99 KIT
23 hematologic cancer 9.1 CD5 KIT

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to Thymic Epithelial Tumor

Symptoms & Phenotypes for Thymic Epithelial Tumor

GenomeRNAi Phenotypes related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.28 CD99
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.28 KIT
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.28 KIT
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.28 CD99
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.28 CD99
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.28 CD99
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.28 CD99 KIT
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.28 CD99

Drugs & Therapeutics for Thymic Epithelial Tumor

Drugs for Thymic Epithelial Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
3
Pembrolizumab Approved Phase 2 1374853-91-4
4
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
5
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
6 Antimitotic Agents Phase 2
7 Protein Kinase Inhibitors Phase 2
8 Albumin-Bound Paclitaxel Phase 2
9 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Neoadjuvant Chemotherapy for Locally Advanced Thymic Cancer Completed NCT01312324 Phase 2 neoadjuvant docetaxel/cisplatin
2 Selinexor in Patients With Advanced Thymic Epithelial Tumor Progressing After Primary Chemotherapy Recruiting NCT03193437 Phase 2 Open Label Selinexor
3 Selinexor in Patients With Advanced Thymoma and Thymic Carcinoma Recruiting NCT03466827 Phase 2 Selinexor
4 Trial of Sunitinib in Patients With Type B3 Thymoma or Thymic Carcinoma in Second and Further Lines (Style Trial) Recruiting NCT03449173 Phase 2 Sunitinib
5 A Study of Pembrolizumab for Patients With Thymic Epithelial Tumor Not yet recruiting NCT02607631 Phase 2 Pembrolizumab
6 A Phase II Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumor Not yet recruiting NCT03219554 Phase 2 Palbociclib
7 Paclitaxel and Cisplatin for Thymic Neoplasm Terminated NCT00818090 Phase 2 paclitaxel and cisplatin
8 Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors Completed NCT03288662 Not Applicable
9 French National Observatory of Patients With Thymic Epithelial Tumor Recruiting NCT02724696
10 Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors Recruiting NCT02146170
11 Preoperative Prediction of of Thymic Epithelial Tumors by Diffusion-Weighted MR Imaging Not yet recruiting NCT03212027

Search NIH Clinical Center for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

Anatomical Context for Thymic Epithelial Tumor

MalaCards organs/tissues related to Thymic Epithelial Tumor:

41
Thymus, Lung, Heart

Publications for Thymic Epithelial Tumor

Articles related to Thymic Epithelial Tumor:

(show top 50) (show all 73)
# Title Authors Year
1
Comparison of Interobserver Agreement and Diagnostic Accuracy for IASLC/ITMIG Thymic Epithelial Tumor Staging Among Co-registered FDG-PET/MRI, Whole-body MRI, Integrated FDG-PET/CT, and Conventional Imaging Examination with and without Contrast Media Administrations. ( 29395795 )
2018
2
Diagnosis of thymic epithelial tumor subtypes by a quantitative proteomic approach. ( 29645059 )
2018
3
Pembrolizumab for Patients With Refractory or Relapsed Thymic Epithelial Tumor: An Open-Label Phase II Trial. ( 29906252 )
2018
4
A Clinical Observation of Thymic Epithelial Tumor Metastatic to Breast. ( 29887792 )
2018
5
Antineutrophil Cytoplasmic Antibody-Associated Rapid Progressive Glomerulonephritis after Pembrolizumab Treatment in Thymic Epithelial Tumor: A Case Report. ( 28342816 )
2017
6
GTF2I mutation frequently occurs in more indolent thymic epithelial tumors and predicts better prognosis. ( 28676218 )
2017
7
Elevated CRP levels predict poor outcome and tumor recurrence in patients with thymic epithelial tumors: A pro- and retrospective analysis. ( 28514756 )
2017
8
Thymic Epithelial Tumors phenotype relies on miR-145-5p epigenetic regulation. ( 28486946 )
2017
9
GTF2I Mutations Are Common in Thymic Epithelial Tumors But Not in Hematological Malignancies. ( 28982856 )
2017
10
Expression of cathepsins V and S in thymic epithelial tumors. ( 27771373 )
2017
11
Occasional detection of thymic epithelial tumor 4 years after diagnosis of adult onset Still disease: A challenging case report and immuno-oncological considerations coming from pertinent literature review. ( 27603335 )
2016
12
Thymic Epithelial Tumor-Associated Cytopenia: A 10-Year Observational Study in France. ( 26768832 )
2016
13
Differentiating the grades of thymic epithelial tumor malignancy using textural features of intratumoral heterogeneity via (18)F-FDG PET/CT. ( 26868139 )
2016
14
Expression of programmed death 1 (PD-1) and its ligand (PD-L1) in thymic epithelial tumors: Impact on treatment efficacy and alteration in expression after chemotherapy. ( 27565906 )
2016
15
Circulating miR-21-5p and miR-148a-3p as emerging non-invasive biomarkers in thymic epithelial tumors. ( 26575977 )
2016
16
Thymic Hyperplasia After Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. ( 27865872 )
2016
17
Value of volume-based early metabolic response in patients with unresectable thymic epithelial tumor. ( 27597277 )
2016
18
Erratum: Omasa M, Date H, Sozu T, Sato T, Nagai K, Yokoi K, Okamoto T, Ikeda N, Tanaka F, and Maniwa Y, and the Japanese Association for Research on the Thymus. Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: The Japanese Association for Research on the Thymus Database Study. Cancer. doi: 10.1002/cncr.29166. ( 26057775 )
2015
19
Diffuse high intensity PD-L1 staining in thymic epithelial tumors. ( 25402569 )
2015
20
Perplexing histologic classification of thymic epithelial tumor. ( 25997137 )
2015
21
Postoperative radiotherapy is effective for thymic carcinoma but not for thymoma in stage II and III thymic epithelial tumors: The Japanese Association for Research on the Thymus Database Study. ( 25565590 )
2015
22
Expression of pRb and p16INK4 in human thymic epithelial tumors in relation to the presence of human polyomavirus 7. ( 26537237 )
2015
23
Methylation and expression profiles of MGMT gene in thymic epithelial tumors. ( 24388682 )
2014
24
The presence of extrathoracic metastasis is more prognostic of survival than Masaoka stage (IVa/IVb) in metastatic thymic epithelial tumor: a retrospective cohort study. ( 24954359 )
2014
25
A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors. ( 24974848 )
2014
26
Expression of RAGE and HMGB1 in thymic epithelial tumors, thymic hyperplasia and regular thymic morphology. ( 24705787 )
2014
27
Difference in distribution profiles between CD163+ tumor-associated macrophages and S100+ dendritic cells in thymic epithelial tumors. ( 25499804 )
2014
28
Surgical Approaches for Stage IVA Thymic Epithelial Tumors. ( 24459636 )
2014
29
STAT3 expression correlates with prognosis of thymic epithelial tumors. ( 23590999 )
2013
30
Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors. ( 23444221 )
2013
31
Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor. ( 23695010 )
2013
32
Expression of c-Jun, p73, Casp9, and N-ras in thymic epithelial tumors: relationship with the current WHO classification systems. ( 22974165 )
2012
33
Is There a Role of Postoperative Radiation Therapy in Completely Resected Stage I/II Thymic Epithelial Tumor? ( 23091442 )
2012
34
NUT rearrangement is uncommon in human thymic epithelial tumors. ( 22425924 )
2012
35
Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration. ( 23896935 )
2011
36
Heat shock protein 90-sheltered overexpression of insulin-like growth factor 1 receptor contributes to malignancy of thymic epithelial tumors. ( 21372220 )
2011
37
MUC1 expression in thymic epithelial tumors: MUC1 may be useful marker as differential diagnosis between type B3 thymoma and thymic carcinoma. ( 21253760 )
2011
38
Expression of excision repair cross-complementation group 1, breast cancer susceptibility 1, and I^ III-tubulin in thymic epithelial tumors. ( 21289518 )
2011
39
Expression of proteasome subunit I^5t in thymic epithelial tumors. ( 21836487 )
2011
40
Thymic epithelial tumor with heart metastasis in a horse. ( 20814442 )
2010
41
Expression and mutational status of c-kit in thymic epithelial tumors. ( 20651610 )
2010
42
CD98 expression is associated with the grade of malignancy in thymic epithelial tumors. ( 20811665 )
2010
43
Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. ( 19901887 )
2009
44
Computed tomographic findings and prognosis in thymic epithelial tumor patients. ( 18830115 )
2008
45
Absence of gene mutations in KIT-positive thymic epithelial tumors. ( 18486988 )
2008
46
Adjuvant radiotherapy for thymic epithelial tumor: treatment results and prognostic factors. ( 17762439 )
2007
47
[Correlation between MMP-2 activation and MT1-MMP mRNA expression in thymic epithelial tumors]. ( 16608644 )
2006
48
Expression and mutation statuses of epidermal growth factor receptor in thymic epithelial tumors. ( 16762968 )
2006
49
Expression of neurotrophin receptors in surgically resected thymic epithelial tumors. ( 16125946 )
2005
50
Immunohistochemical KIT (CD117) expression in thymic epithelial tumors. ( 16002927 )
2005

Variations for Thymic Epithelial Tumor

Expression for Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for Thymic Epithelial Tumor

Pathways related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 CD5 KIT
2 10.94 CD5 KIT
3 10.35 CD5 KIT

GO Terms for Thymic Epithelial Tumor

Cellular components related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 CD5 KIT
2 integral component of plasma membrane GO:0005887 8.8 CD5 CD99 KIT

Molecular functions related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.62 CD5 KIT

Sources for Thymic Epithelial Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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