MCID: THY042
MIFTS: 25

Thymic Epithelial Tumor

Categories: Rare diseases

Aliases & Classifications for Thymic Epithelial Tumor

MalaCards integrated aliases for Thymic Epithelial Tumor:

Name: Thymic Epithelial Tumor 52 71
Epithelial Tumor of Thymus 52
Thymoma, Adult 52

Classifications:



External Ids:

UMLS 71 C1266101

Summaries for Thymic Epithelial Tumor

MalaCards based summary : Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and thymic carcinoma. An important gene associated with Thymic Epithelial Tumor is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Pembrolizumab and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include thymus, t cells and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Thymic Epithelial Tumor

Diseases related to Thymic Epithelial Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 thymoma 31.0 KIT CD5
2 thymic carcinoma 30.9 KIT CD5
3 mediastinal cancer 29.7 KIT CD5
4 type c thymoma 29.6 KIT CD5
5 thymoma, familial 11.9
6 thymic epithelial neoplasm 11.8
7 thymoma type b 11.8
8 thymoma type a 11.4
9 thymoma type ab 11.4
10 myasthenia gravis 10.7
11 neutropenia 10.3
12 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.3
13 epithelial malignant thymoma 10.3
14 autoimmune disease 10.2
15 neuroendocrine tumor 10.2
16 thymus squamous cell carcinoma 10.2
17 cortical thymoma 10.2
18 paraneoplastic syndromes 10.2
19 hemopericardium 10.1
20 pericardial effusion 10.1
21 dendritic cell thymoma 10.1
22 lung cancer 10.0
23 gastrointestinal stromal tumor 10.0
24 good syndrome 10.0
25 lymphoma 10.0
26 neuroendocrine carcinoma 10.0
27 glomerulonephritis 10.0
28 mixed type thymoma 10.0
29 seminoma 10.0
30 lymphoepithelioma-like carcinoma 10.0
31 thyroiditis 10.0
32 thymic neuroendocrine tumor 10.0
33 pulmonary vein stenosis 9.9 KIT CD99
34 gliofibroma 9.9 KIT CD99
35 malignant teratoma 9.9 KIT CD99
36 teratoma 9.9 KIT CD99
37 hemangiopericytoma, malignant 9.9 KIT CD99
38 synovium cancer 9.9 KIT CD99
39 chondrosarcoma, extraskeletal myxoid 9.9 KIT CD99
40 bladder cancer 9.9
41 burkitt lymphoma 9.9
42 carcinoid tumors, intestinal 9.9
43 esophageal cancer 9.9
44 retinoblastoma 9.9
45 sarcoidosis 1 9.9
46 small cell cancer of the lung 9.9
47 lymphoma, hodgkin, classic 9.9
48 sjogren syndrome 9.9
49 nasopharyngeal carcinoma 9.9
50 myelodysplastic syndrome 9.9

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to Thymic Epithelial Tumor

Symptoms & Phenotypes for Thymic Epithelial Tumor

GenomeRNAi Phenotypes related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.32 CD99
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.32 KIT
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.32 KIT
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.32 CD99
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.32 CD99
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.32 CD99
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.32 CD99 KIT
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.32 CD99
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.32 CD99

Drugs & Therapeutics for Thymic Epithelial Tumor

Drugs for Thymic Epithelial Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
3
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
4
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
5 Antineoplastic Agents, Immunological Phase 2
6 Albumin-Bound Paclitaxel Phase 2
7 Antimitotic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase II Study of Pembrolizumab for Patients With Thymic Epithelial Tumor Who Progressed After at Least One Previous Regimen of Cisplatin-Containing Chemotherapy Unknown status NCT02607631 Phase 2 Pembrolizumab
2 A Phase 2, Open-label Study of Selinexor (KPT-330) in Patients With Advanced Thymic Epithelial Tumor (TET) Progressing After Primary Chemotherapy (SELECT) Recruiting NCT03193437 Phase 2 Open Label Selinexor
3 A Phase II, Neo-adjuvant Pembrolizumab, Docetaxel, Cisplatin Therapy Followed by Surgery and Pembrolizumab Consolidation Therapy in Locally Advanced Thymic Epithelial Tumor (TET) Not yet recruiting NCT03858582 Phase 2 pembrolizumab
4 A Phase II Study of Paclitaxel and Cisplatin in Previously Untreated, Unresectable Invasive Thymoma or Thymic Carcinoma Terminated NCT00818090 Phase 2 paclitaxel and cisplatin
5 Preoperative Prediction of the Pathological Classification of Thymic Epithelial Tumors by Apparent Diffusion Coefficient Using Ultra-high B-values Unknown status NCT03212027
6 French National Observatory of Patients With Thymic Epithelial Tumor Recruiting NCT02724696
7 A Pilot Study of Inpatient Hospice With Procurement of Tissue on Expiration in Thoracic Malignancies Recruiting NCT01851395

Search NIH Clinical Center for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

Anatomical Context for Thymic Epithelial Tumor

MalaCards organs/tissues related to Thymic Epithelial Tumor:

40
Thymus, T Cells, Bone, Lung, Bone Marrow, Breast, Heart

Publications for Thymic Epithelial Tumor

Articles related to Thymic Epithelial Tumor:

(show top 50) (show all 89)
# Title Authors PMID Year
1
High Neutrophil Count as a Negative Prognostic Factor for Relapse in Patients with Thymic Epithelial Tumor. 61
31993857 2020
2
The change of therapeutic trends in the thymic epithelial tumor. 61
32030291 2019
3
Thymic epithelial tumor treatment in Japan: analysis of hospital cancer registry and insurance claims data, 2012-2014. 61
31829410 2019
4
Thymic small cell carcinoma associated with Lambert-Eaton myasthenic syndrome. 61
31586614 2019
5
[Multilocular Thymic Cyst with Calcification;Report of a Case]. 61
31588118 2019
6
Surgical approach for thymic epithelial tumor. 61
31559082 2019
7
Pembrolizumab for Patients With Refractory or Relapsed Thymic Epithelial Tumor: An Open-Label Phase II Trial. 61
29906252 2019
8
Thymic epithelial tumor complicated by immunological abnormalities: results from a single-center retrospective study in China. 61
31179102 2019
9
Microscopic polyangiitis associated with thymic tumor: a case report and review of the literature. 61
30961527 2019
10
Micronodular thymoma with lymphoid stroma: report of two cases and review of literature. 61
31934213 2019
11
Immune biomarkers in thymic epithelial tumors: expression patterns, prognostic value and comparison of diagnostic tests for PD-L1. 61
31827799 2019
12
Analysis of surgical treatment of Masaoka stage III-IV thymic epithelial tumors. 61
30132223 2018
13
Patterns of Failure Following Postoperative Radiation Therapy Based on "Tumor Bed With Margin" for Stage II to IV Type C Thymic Epithelial Tumor. 61
30099130 2018
14
Successful Use of Pembrolizumab to Treat Refractory Thymic Carcinoma with High PD-L1 Expression. 61
30483099 2018
15
Usefulness of Volume Perfusion Computed Tomography in Differentiating Histologic Subtypes of Thymic Epithelial Tumors. 61
29553964 2018
16
Diagnosis of thymic epithelial tumor subtypes by a quantitative proteomic approach. 61
29645059 2018
17
A Clinical Observation of Thymic Epithelial Tumor Metastatic to Breast. 61
29887792 2018
18
Focal adhesion kinase is overexpressed in thymic epithelial tumors and may serve as an independent prognostic biomarker. 61
29435030 2018
19
Incidental Anterior Mediastinal Nodular Lesions on Chest CT in Asymptomatic Subjects. 61
29233791 2018
20
Comparison of Interobserver Agreement and Diagnostic Accuracy for IASLC/ITMIG Thymic Epithelial Tumor Staging Among Co-registered FDG-PET/MRI, Whole-body MRI, Integrated FDG-PET/CT, and Conventional Imaging Examination with and without Contrast Media Administrations. 61
29395795 2018
21
Dedifferentiated primary mediastinal liposarcoma mimicking a thymic tumor. 61
29449733 2017
22
JLCS medical practice guidelines for thymic tumors: summary of recommendations. 61
29036455 2017
23
Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors. 61
28819023 2017
24
Antineutrophil Cytoplasmic Antibody-Associated Rapid Progressive Glomerulonephritis after Pembrolizumab Treatment in Thymic Epithelial Tumor: A Case Report. 61
28342816 2017
25
Quantitative computed tomography texture analysis for estimating histological subtypes of thymic epithelial tumors. 61
28624025 2017
26
Thymic Hyperplasia after Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. 61
27865872 2017
27
A Rare Tumor with a Very Rare Initial Presentation: Thymic Carcinoma as Bone Marrow Metastasis. 61
28116199 2017
28
An unusual combined thymic carcinoma composed of squamous cell carcinoma and type AB thymoma: a rare case report. 61
28095872 2017
29
Thymoma Metastasis to the Semimembranosus Muscle. 61
28203162 2017
30
Value of volume-based early metabolic response in patients with unresectable thymic epithelial tumor. 61
27597277 2016
31
Occasional detection of thymic epithelial tumor 4 years after diagnosis of adult onset Still disease: A challenging case report and immuno-oncological considerations coming from pertinent literature review. 61
27603335 2016
32
Robotic Thymectomy in Anterior Mediastinal Mass: Propensity Score Matching Study With Transsternal Thymectomy. 61
27234580 2016
33
Trends and current status of general thoracic surgery in Japan revealed by review of nationwide databases. 61
27651932 2016
34
Differentiating the grades of thymic epithelial tumor malignancy using textural features of intratumoral heterogeneity via (18)F-FDG PET/CT. 61
26868139 2016
35
Thymic Epithelial Tumor-Associated Cytopenia: A 10-Year Observational Study in France. 61
26768832 2016
36
Rare frequency of gene variation and survival analysis in thymic epithelial tumors. 61
27789964 2016
37
[Management for Life-threatening Mediastinal Tumor]. 61
26197918 2015
38
Perplexing histologic classification of thymic epithelial tumor. 61
25997137 2015
39
Diffuse high intensity PD-L1 staining in thymic epithelial tumors. 61
25402569 2015
40
Establishment and characterization of a novel cell line derived from thymoma with myasthenia gravis patients. 61
26273358 2015
41
Thymic epithelial tumors: prognostic determinants among clinical, histopathologic, and computed tomography findings. 61
25534526 2015
42
[Diaphragmatic hernia complicated with diaphragmatic resection by automatic stapling device]. 61
25292370 2014
43
Prognostic factors of patients with thymic carcinoma after surgery: a retrospective analysis of 58 cases. 61
24615610 2014
44
The presence of extrathoracic metastasis is more prognostic of survival than Masaoka stage (IVa/IVb) in metastatic thymic epithelial tumor: a retrospective cohort study. 61
24954359 2014
45
[Diagnosis and differential diagnosis of thymic epithelial tumor]. 61
25327807 2014
46
[Research status of molecular targeted therapy in thymic epithelial tumors]. 61
24949690 2014
47
Primary papillary carcinoma of the thymus with invasion into subcutaneous tissue through the sternum. 61
24885502 2014
48
¹⁸F-FDG uptake on PET is a predictive marker of thymidylate synthase expression in patients with thoracic neoplasms. 61
24173608 2014
49
Unusual combined thymic mucoepidermoid carcinoma and thymoma: a case report and review of literature. 61
24444077 2014
50
Imaging of a case of metaplastic thymoma on 18F-FDG PET/CT. 61
24212449 2013

Variations for Thymic Epithelial Tumor

Expression for Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for Thymic Epithelial Tumor

Pathways related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 KIT CD5
2 10.95 KIT CD5
3 10.35 KIT CD5

GO Terms for Thymic Epithelial Tumor

Cellular components related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 KIT CD5
2 integral component of plasma membrane GO:0005887 8.8 KIT CD99 CD5

Sources for Thymic Epithelial Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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