MCID: THY042
MIFTS: 28

Thymic Epithelial Tumor

Categories: Rare diseases

Aliases & Classifications for Thymic Epithelial Tumor

MalaCards integrated aliases for Thymic Epithelial Tumor:

Name: Thymic Epithelial Tumor 54 74
Epithelial Tumor of Thymus 54
Thymoma, Adult 54

Classifications:



External Ids:

UMLS 74 C1266101

Summaries for Thymic Epithelial Tumor

MalaCards based summary : Thymic Epithelial Tumor, also known as epithelial tumor of thymus, is related to thymoma and thymoma, familial. An important gene associated with Thymic Epithelial Tumor is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs Pembrolizumab and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include thymus and lung, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Thymic Epithelial Tumor

Graphical network of the top 20 diseases related to Thymic Epithelial Tumor:



Diseases related to Thymic Epithelial Tumor

Symptoms & Phenotypes for Thymic Epithelial Tumor

GenomeRNAi Phenotypes related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-10 9.28 CD99
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.28 KIT
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.28 KIT
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.28 CD99
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.28 CD99
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.28 CD99
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.28 CD99 KIT
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.28 CD99

Drugs & Therapeutics for Thymic Epithelial Tumor

Drugs for Thymic Epithelial Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pembrolizumab Approved Phase 2 1374853-91-4
2
Cisplatin Approved Phase 2 15663-27-1 441203 84093 2767
3
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
4
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
5
Etoposide Approved Phase 2 33419-42-0 36462
6
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
7
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
8 Antineoplastic Agents, Immunological Phase 2
9 Antimitotic Agents Phase 2
10 tyrosine Phase 2
11 Angiogenesis Inhibitors Phase 2
12 Protein Kinase Inhibitors Phase 2
13 Angiogenesis Modulating Agents Phase 2
14 Etoposide phosphate Phase 2
15 Albumin-Bound Paclitaxel Phase 2
16 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Study of Pembrolizumab for Patients With Thymic Epithelial Tumor Unknown status NCT02607631 Phase 2 Pembrolizumab
2 Neoadjuvant Chemotherapy for Locally Advanced Thymic Cancer Completed NCT01312324 Phase 2 neoadjuvant docetaxel/cisplatin
3 Selinexor in Patients With Advanced Thymic Epithelial Tumor Progressing After Primary Chemotherapy Recruiting NCT03193437 Phase 2 Open Label Selinexor
4 Selinexor in Patients With Advanced Thymoma and Thymic Carcinoma Recruiting NCT03466827 Phase 2 Selinexor
5 Trial of Sunitinib in Patients With Type B3 Thymoma or Thymic Carcinoma in Second and Further Lines (Style Trial) Recruiting NCT03449173 Phase 2 Sunitinib
6 Chemoradiotherapy for Limited Advanced Unresectable Thymic Epithelial Tumors Active, not recruiting NCT02636556 Phase 2
7 neoadjuvant_thymic Epithelial Tumor Not yet recruiting NCT03858582 Phase 2 pembrolizumab
8 A Phase II Study of Palbociclib for Recurrent or Refractory Advanced Thymic Epithelial Tumor Not yet recruiting NCT03219554 Phase 2 Palbociclib
9 Paclitaxel and Cisplatin for Thymic Neoplasm Terminated NCT00818090 Phase 2 paclitaxel and cisplatin
10 Relationship Between Computed Tomography Manifestation and Histopathological Classification of Thymic Epithelial Tumors Completed NCT03288662 Not Applicable
11 French National Observatory of Patients With Thymic Epithelial Tumor Recruiting NCT02724696
12 Tissue Procurement and Natural History Study of People With Non-Small Cell Lung Cancer, Small Cell Lung Cancer, Extrapulmonary Small Cell Cancer, Pulmonary Neuroendocrine Tumors, and Thymic Epithelial Tumors Recruiting NCT02146170
13 Rapid Autopsy and Procurement of Cancer Tissue Recruiting NCT01851395
14 Preoperative Prediction of of Thymic Epithelial Tumors by Diffusion-Weighted MR Imaging Not yet recruiting NCT03212027

Search NIH Clinical Center for Thymic Epithelial Tumor

Genetic Tests for Thymic Epithelial Tumor

Anatomical Context for Thymic Epithelial Tumor

MalaCards organs/tissues related to Thymic Epithelial Tumor:

42
Thymus, Lung

Publications for Thymic Epithelial Tumor

Articles related to Thymic Epithelial Tumor:

(show all 23)
# Title Authors Year
1
Comparison of Interobserver Agreement and Diagnostic Accuracy for IASLC/ITMIG Thymic Epithelial Tumor Staging Among Co-registered FDG-PET/MRI, Whole-body MRI, Integrated FDG-PET/CT, and Conventional Imaging Examination with and without Contrast Media Administrations. ( 29395795 )
2018
2
Diagnosis of thymic epithelial tumor subtypes by a quantitative proteomic approach. ( 29645059 )
2018
3
Pembrolizumab for Patients With Refractory or Relapsed Thymic Epithelial Tumor: An Open-Label Phase II Trial. ( 29906252 )
2018
4
A Clinical Observation of Thymic Epithelial Tumor Metastatic to Breast. ( 29887792 )
2018
5
Patterns of Failure following Postoperative Radiation Therapy Based on "Tumor Bed with Margin" for Stage II-IV Type C Thymic Epithelial Tumor. ( 30099130 )
2018
6
Antineutrophil Cytoplasmic Antibody-Associated Rapid Progressive Glomerulonephritis after Pembrolizumab Treatment in Thymic Epithelial Tumor: A Case Report. ( 28342816 )
2017
7
Occasional detection of thymic epithelial tumor 4 years after diagnosis of adult onset Still disease: A challenging case report and immuno-oncological considerations coming from pertinent literature review. ( 27603335 )
2016
8
Thymic Epithelial Tumor-Associated Cytopenia: A 10-Year Observational Study in France. ( 26768832 )
2016
9
Differentiating the grades of thymic epithelial tumor malignancy using textural features of intratumoral heterogeneity via (18)F-FDG PET/CT. ( 26868139 )
2016
10
Thymic Hyperplasia After Treatment of ACTH-Dependent Cushing's Syndrome Can Be Mistaken for a Thymic Epithelial Tumor. ( 27865872 )
2016
11
Value of volume-based early metabolic response in patients with unresectable thymic epithelial tumor. ( 27597277 )
2016
12
Perplexing histologic classification of thymic epithelial tumor. ( 25997137 )
2015
13
The presence of extrathoracic metastasis is more prognostic of survival than Masaoka stage (IVa/IVb) in metastatic thymic epithelial tumor: a retrospective cohort study. ( 24954359 )
2014
14
Tumor-to-tumor metastasis: breast cancer metastatic to thymic epithelial tumor. ( 23695010 )
2013
15
Is There a Role of Postoperative Radiation Therapy in Completely Resected Stage I/II Thymic Epithelial Tumor? ( 23091442 )
2012
16
Successful diagnosis of a combined thymic epithelial tumor by endobronchial ultrasound-guided transbronchial needle aspiration. ( 23896935 )
2011
17
Thymic epithelial tumor with heart metastasis in a horse. ( 20814442 )
2010
18
Type B3 thymic epithelial tumor in an adolescent detected by immunohistochemical staining for CD5, CD99, and KIT (CD117): a case report. ( 19901887 )
2009
19
Computed tomographic findings and prognosis in thymic epithelial tumor patients. ( 18830115 )
2008
20
Adjuvant radiotherapy for thymic epithelial tumor: treatment results and prognostic factors. ( 17762439 )
2007
21
Multimodality treatment program in invasive thymic epithelial tumor. ( 15685027 )
2005
22
Thymic epithelial tumor progression in an SV40T transgenic mouse model. Cortical thymoma-thymic carcinoma sequence. ( 9463585 )
1998
23
Paraneoplastic myasthenia gravis: detection of anti-MGT30 (titin) antibodies predicts thymic epithelial tumor. ( 9371941 )
1997

Variations for Thymic Epithelial Tumor

Expression for Thymic Epithelial Tumor

Search GEO for disease gene expression data for Thymic Epithelial Tumor.

Pathways for Thymic Epithelial Tumor

Pathways related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.22 CD5 KIT
2 10.94 CD5 KIT
3 10.35 CD5 KIT

GO Terms for Thymic Epithelial Tumor

Cellular components related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 CD5 KIT
2 integral component of plasma membrane GO:0005887 8.8 CD5 CD99 KIT

Molecular functions related to Thymic Epithelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.32 CD5

Sources for Thymic Epithelial Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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