MCID: THY108
MIFTS: 33

Thymic Neuroendocrine Tumor

Categories: Endocrine diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Thymic Neuroendocrine Tumor

Summaries for Thymic Neuroendocrine Tumor

MalaCards based summary : Thymic Neuroendocrine Tumor is related to neuroendocrine tumor and multiple endocrine neoplasia, type i. An important gene associated with Thymic Neuroendocrine Tumor is MEN1 (Menin 1), and among its related pathways/superpathways are ErbB signaling pathway and T cell receptor signaling pathway. Affiliated tissues include pituitary, thymus and pancreatic islet, and related phenotypes are neoplasm of the thymus and mediastinal lymphadenopathy

Related Diseases for Thymic Neuroendocrine Tumor

Diseases related to Thymic Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.2
2 multiple endocrine neoplasia, type i 9.9
3 paraganglioma 9.9
4 thymic carcinoma 9.9
5 multiple endocrine neoplasia 9.9
6 duodenum cancer 9.7 HRAS MEN1
7 gastrointestinal system benign neoplasm 9.7 HRAS MEN1
8 small intestine cancer 9.7 HRAS MEN1
9 cell type benign neoplasm 9.6 HRAS MEN1
10 endocrine gland cancer 9.6 HRAS MEN1
11 thyroid cancer, nonmedullary, 2 9.4 HRAS MEN1

Graphical network of the top 20 diseases related to Thymic Neuroendocrine Tumor:



Diseases related to Thymic Neuroendocrine Tumor

Symptoms & Phenotypes for Thymic Neuroendocrine Tumor

Human phenotypes related to Thymic Neuroendocrine Tumor:

60 33 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neoplasm of the thymus 60 33 obligate (100%) Obligate (100%) HP:0100521
2 mediastinal lymphadenopathy 60 33 hallmark (90%) Very frequent (99-80%) HP:0100721
3 weight loss 60 33 frequent (33%) Frequent (79-30%) HP:0001824
4 chest pain 60 33 frequent (33%) Frequent (79-30%) HP:0100749
5 carcinoid tumor 60 33 frequent (33%) Frequent (79-30%) HP:0100570
6 cough 60 33 frequent (33%) Frequent (79-30%) HP:0012735
7 increased circulating acth level 60 33 frequent (33%) Frequent (79-30%) HP:0003154
8 increased circulating cortisol level 60 33 frequent (33%) Frequent (79-30%) HP:0003118
9 prominent veins on trunk 60 33 frequent (33%) Frequent (79-30%) HP:0007457
10 abnormal breath sound 60 33 frequent (33%) Frequent (79-30%) HP:0030829
11 chronic noninfectious lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0002730
12 abnormal vena cava morphology 33 frequent (33%) HP:0005345
13 osteopenia 60 33 occasional (7.5%) Occasional (29-5%) HP:0000938
14 hypercalcemia 60 33 occasional (7.5%) Occasional (29-5%) HP:0003072
15 pituitary prolactin cell adenoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0006767
16 pituitary null cell adenoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0011761
17 prolactin excess 60 33 occasional (7.5%) Occasional (29-5%) HP:0000870
18 primary hyperparathyroidism 60 33 occasional (7.5%) Occasional (29-5%) HP:0008200
19 calcium nephrolithiasis 60 33 occasional (7.5%) Occasional (29-5%) HP:0004724
20 pancreatic islet cell adenoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0008261
21 neuroendocrine neoplasm 60 Obligate (100%)
22 pituitary adenoma 60 Occasional (29-5%)
23 abnormality of the mediastinum 60 Very frequent (99-80%)
24 abnormality of the vena cava 60 Frequent (79-30%)
25 neoplasm of the endocrine system 60 Frequent (79-30%)

GenomeRNAi Phenotypes related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.61 HRAS PAK1
2 Decreased viability GR00221-A-1 9.61 HRAS
3 Decreased viability GR00221-A-2 9.61 HRAS PAK1
4 Decreased viability GR00221-A-3 9.61 HRAS
5 Decreased viability GR00301-A 9.61 PAK1
6 Decreased viability GR00402-S-2 9.61 HRAS PAK1
7 Increased cell migration GR00055-A-3 8.62 HRAS PAK1

Drugs & Therapeutics for Thymic Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Thymic Neuroendocrine Tumor

Genetic Tests for Thymic Neuroendocrine Tumor

Anatomical Context for Thymic Neuroendocrine Tumor

MalaCards organs/tissues related to Thymic Neuroendocrine Tumor:

42
Pituitary, Thymus, Pancreatic Islet, Thyroid, Small Intestine

Publications for Thymic Neuroendocrine Tumor

Articles related to Thymic Neuroendocrine Tumor:

# Title Authors Year
1
Whole exome sequencing of thymic neuroendocrine tumor with ectopic ACTH syndrome. ( 27913610 )
2017
2
Ectopic ACTH syndrome caused by desmopressin-responsive thymic neuroendocrine tumor. ( 25819222 )
2015
3
Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome. ( 23676563 )
2013
4
Thymic neuroendocrine tumor (thymic carcinoid): a clinicopathologic study in 15 patients. ( 10086551 )
1999

Variations for Thymic Neuroendocrine Tumor

Expression for Thymic Neuroendocrine Tumor

Search GEO for disease gene expression data for Thymic Neuroendocrine Tumor.

Pathways for Thymic Neuroendocrine Tumor

Pathways related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.18 HRAS PAK1
2
Show member pathways
12.14 HRAS PAK1
3
Show member pathways
12.08 HRAS PAK1
4
Show member pathways
12.03 HRAS PAK1
5
Show member pathways
12.02 HRAS PAK1
6
Show member pathways
12.02 HRAS PAK1
7
Show member pathways
11.98 HRAS PAK1
8
Show member pathways
11.97 HRAS PAK1
9
Show member pathways
11.96 HRAS PAK1
10
Show member pathways
11.91 HRAS PAK1
11
Show member pathways
11.89 HRAS PAK1
12 11.85 HRAS PAK1
13
Show member pathways
11.81 HRAS PAK1
14 11.78 HRAS PAK1
15
Show member pathways
11.75 HRAS PAK1
16
Show member pathways
11.72 HRAS PAK1
17 11.69 HRAS PAK1
18
Show member pathways
11.61 HRAS PAK1
19
Show member pathways
11.5 HRAS PAK1
20
Show member pathways
11.29 HRAS PAK1
21 11.14 HRAS PAK1
22
Show member pathways
11.06 HRAS PAK1
23 11.01 HRAS PAK1
24 10.88 HRAS PAK1
25 10.6 HRAS PAK1
26 10.6 HRAS PAK1
27 9.97 HRAS PAK1

GO Terms for Thymic Neuroendocrine Tumor

Biological processes related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.4 HRAS PAK1
2 positive regulation of protein phosphorylation GO:0001934 9.37 HRAS PAK1
3 T cell receptor signaling pathway GO:0050852 9.32 HRAS PAK1
4 ephrin receptor signaling pathway GO:0048013 9.26 HRAS PAK1
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.16 HRAS PAK1
6 positive regulation of protein targeting to membrane GO:0090314 8.96 HRAS PAK1
7 MAPK cascade GO:0000165 8.8 HRAS MEN1 PAK1

Sources for Thymic Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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