MCID: THY108
MIFTS: 31

Thymic Neuroendocrine Tumor

Categories: Endocrine diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Thymic Neuroendocrine Tumor

MalaCards integrated aliases for Thymic Neuroendocrine Tumor:

Name: Thymic Neuroendocrine Tumor 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


Summaries for Thymic Neuroendocrine Tumor

MalaCards based summary : Thymic Neuroendocrine Tumor is related to neuroendocrine tumor and multiple endocrine neoplasia. An important gene associated with Thymic Neuroendocrine Tumor is MEN1 (Menin 1), and among its related pathways/superpathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases and Prolactin Signaling Pathway. Affiliated tissues include pituitary, thymus and pancreatic islet, and related phenotypes are neoplasm of the thymus and mediastinal lymphadenopathy

Related Diseases for Thymic Neuroendocrine Tumor

Graphical network of the top 20 diseases related to Thymic Neuroendocrine Tumor:



Diseases related to Thymic Neuroendocrine Tumor

Symptoms & Phenotypes for Thymic Neuroendocrine Tumor

Human phenotypes related to Thymic Neuroendocrine Tumor:

58 31 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neoplasm of the thymus 58 31 obligate (100%) Obligate (100%) HP:0100521
2 mediastinal lymphadenopathy 58 31 hallmark (90%) Very frequent (99-80%) HP:0100721
3 abnormal vena cava morphology 58 31 frequent (33%) Frequent (79-30%) HP:0005345
4 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
5 cough 58 31 frequent (33%) Frequent (79-30%) HP:0012735
6 chest pain 58 31 frequent (33%) Frequent (79-30%) HP:0100749
7 carcinoid tumor 58 31 frequent (33%) Frequent (79-30%) HP:0100570
8 increased circulating acth level 58 31 frequent (33%) Frequent (79-30%) HP:0003154
9 increased circulating cortisol level 58 31 frequent (33%) Frequent (79-30%) HP:0003118
10 abnormal breath sound 58 31 frequent (33%) Frequent (79-30%) HP:0030829
11 prominent veins on trunk 58 31 frequent (33%) Frequent (79-30%) HP:0007457
12 chronic noninfectious lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002730
13 osteopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000938
14 hypercalcemia 58 31 occasional (7.5%) Occasional (29-5%) HP:0003072
15 pituitary prolactin cell adenoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0006767
16 pituitary null cell adenoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0011761
17 primary hyperparathyroidism 58 31 occasional (7.5%) Occasional (29-5%) HP:0008200
18 calcium nephrolithiasis 58 31 occasional (7.5%) Occasional (29-5%) HP:0004724
19 pancreatic islet cell adenoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0008261
20 increased circulating prolactin concentration 31 occasional (7.5%) HP:0000870
21 neuroendocrine neoplasm 58 Obligate (100%)
22 pituitary adenoma 58 Occasional (29-5%)
23 abnormality of the mediastinum 58 Very frequent (99-80%)
24 prolactin excess 58 Occasional (29-5%)
25 neoplasm of the endocrine system 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.61 HRAS PAK1
2 Decreased viability GR00221-A-1 9.61 HRAS
3 Decreased viability GR00221-A-2 9.61 HRAS PAK1
4 Decreased viability GR00221-A-3 9.61 HRAS
5 Decreased viability GR00301-A 9.61 PAK1
6 Decreased viability GR00402-S-2 9.61 HRAS PAK1
7 Increased cell migration GR00055-A-3 8.62 HRAS PAK1

Drugs & Therapeutics for Thymic Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Thymic Neuroendocrine Tumor

Genetic Tests for Thymic Neuroendocrine Tumor

Anatomical Context for Thymic Neuroendocrine Tumor

MalaCards organs/tissues related to Thymic Neuroendocrine Tumor:

40
Pituitary, Thymus, Pancreatic Islet, Neutrophil, Small Intestine, Thyroid

Publications for Thymic Neuroendocrine Tumor

Articles related to Thymic Neuroendocrine Tumor:

(show all 27)
# Title Authors PMID Year
1
High Neutrophil Count as a Negative Prognostic Factor for Relapse in Patients with Thymic Epithelial Tumor. 61
31993857 2020
2
Long-term survival of a patient with an inoperable thymic neuroendocrine tumor stage IIIa under sole treatment with Viscum album extract: A CARE compliant clinical case report. 61
32000435 2020
3
The tumor doubling time is a useful parameter for predicting the histological type of thymic epithelial tumors. 61
31134370 2019
4
[Multiple Endocrine Neoplasia]. 61
31296813 2019
5
ACTH-producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review. 61
31187563 2019
6
Capecitabine and Temozolomide as a Promising Therapy for Advanced Thymic Atypical Carcinoid. 61
30413666 2019
7
A unique case of ectopic Cushing's syndrome from a thymic neuroendocrine carcinoma. 61
30802210 2019
8
Trends in the incidence of thymoma, thymic carcinoma, and thymic neuroendocrine tumor in the United States. 61
31891634 2019
9
Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms. 61
28654574 2018
10
JLCS medical practice guidelines for thymic tumors: summary of recommendations. 61
29036455 2017
11
Whole exome sequencing of thymic neuroendocrine tumor with ectopic ACTH syndrome. 61
27913610 2017
12
[Thymic neuroendocrine tumor: about a case and review of the literature]. 61
28451004 2017
13
Thymic Origin Neuroendocrine Carcinoma Metastasizing to the Orbit in an Otherwise Asymptomatic Patient. 61
25794021 2016
14
Invasive atypical thymic carcinoid: three case reports and literature review. 61
27785065 2016
15
Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors. 61
26317915 2015
16
Primary and metastatic parathyroid malignancies: a rare or underdiagnosed condition? 61
25490272 2015
17
Ectopic ACTH syndrome caused by desmopressin-responsive thymic neuroendocrine tumor. 61
25819222 2015
18
[Thymic neuroendocrine carcinoma with Pompe's disease of the adult]. 61
26502468 2015
19
Ectopic Cushing syndrome associated with thymic carcinoid tumor as the first presentation of MEN1 syndrome-report of a family with MEN1 gene mutation. 61
24218143 2014
20
[Additional external radiotherapy to multiple metastases originating from thymic neuroendocrine tumor following peptide receptor radionuclide therapy: a case report]. 61
25011199 2014
21
Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome. 61
23676563 2013
22
A giant neuroendocrine tumor of the thymus gland causing superior vena cava syndrome. 61
22644816 2012
23
Occult ectopic adrenocorticotropic hormone secretion: diagnostic dilemma and infective consequence. 61
24765481 2012
24
Cushing syndrome secondary to a thymic carcinoid tumor due to multiple endocrine neoplasia type 1. 61
21550948 2011
25
Interpretation of the post-surgical Somatostatin Receptor Scintigram of a Primary Neuroendocrine Tumor of the Thymus: a case report and literature review. 61
15788105 2005
26
[Thymic neuroendocrine tumor: three cases in our practice]. 61
15270528 2004
27
Thymic neuroendocrine tumor (thymic carcinoid): a clinicopathologic study in 15 patients. 61
10086551 1999

Variations for Thymic Neuroendocrine Tumor

Expression for Thymic Neuroendocrine Tumor

Search GEO for disease gene expression data for Thymic Neuroendocrine Tumor.

Pathways for Thymic Neuroendocrine Tumor

Pathways related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.16 PAK1 HRAS
2
Show member pathways
12.07 PAK1 HRAS
3
Show member pathways
12.07 PAK1 HRAS
4
Show member pathways
12.01 PAK1 HRAS
5
Show member pathways
12 PAK1 HRAS
6
Show member pathways
11.96 PAK1 HRAS
7
Show member pathways
11.95 PAK1 HRAS
8
Show member pathways
11.94 PAK1 HRAS
9
Show member pathways
11.94 PAK1 HRAS
10
Show member pathways
11.9 PAK1 HRAS
11
Show member pathways
11.89 PAK1 HRAS
12 11.85 PAK1 HRAS
13 11.77 PAK1 HRAS
14
Show member pathways
11.73 PAK1 HRAS
15
Show member pathways
11.7 PAK1 HRAS
16 11.67 PAK1 HRAS
17
Show member pathways
11.61 PAK1 HRAS
18
Show member pathways
11.5 PAK1 HRAS
19
Show member pathways
11.29 PAK1 HRAS
20
Show member pathways
11.06 PAK1 HRAS
21 11.01 PAK1 HRAS
22 10.88 PAK1 HRAS
23 10.6 PAK1 HRAS
24 9.97 PAK1 HRAS

GO Terms for Thymic Neuroendocrine Tumor

Biological processes related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.4 PAK1 HRAS
2 positive regulation of protein phosphorylation GO:0001934 9.37 PAK1 HRAS
3 T cell receptor signaling pathway GO:0050852 9.32 PAK1 HRAS
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 PAK1 HRAS
5 ephrin receptor signaling pathway GO:0048013 9.16 PAK1 HRAS
6 positive regulation of protein targeting to membrane GO:0090314 8.96 PAK1 HRAS
7 MAPK cascade GO:0000165 8.8 PAK1 MEN1 HRAS

Sources for Thymic Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....