MCID: THY108
MIFTS: 29

Thymic Neuroendocrine Tumor

Categories: Endocrine diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Thymic Neuroendocrine Tumor

MalaCards integrated aliases for Thymic Neuroendocrine Tumor:

Name: Thymic Neuroendocrine Tumor 59

Classifications:

Orphanet: 59  
Rare endocrine diseases


External Ids:

ICD10 via Orphanet 34 D38.4
Orphanet 59 ORPHA97289

Summaries for Thymic Neuroendocrine Tumor

MalaCards based summary : Thymic Neuroendocrine Tumor is related to neuroendocrine tumor and multiple endocrine neoplasia. An important gene associated with Thymic Neuroendocrine Tumor is MEN1 (Menin 1), and among its related pathways/superpathways are ErbB signaling pathway and T cell receptor signaling pathway. Affiliated tissues include pituitary, thymus and pancreatic islet, and related phenotypes are neoplasm of the thymus and mediastinal lymphadenopathy

Related Diseases for Thymic Neuroendocrine Tumor

Diseases related to Thymic Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 23)
# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.4
2 multiple endocrine neoplasia 10.2
3 multiple endocrine neoplasia, type i 10.1
4 horner's syndrome 10.1
5 thymic carcinoma 10.1
6 thymoma, familial 9.9
7 carney triad 9.9
8 small cell carcinoma 9.9
9 paraganglioma 9.9
10 large cell neuroendocrine carcinoma 9.9
11 neuroendocrine carcinoma 9.9
12 thymoma 9.9
13 cranial nerve palsy 9.9
14 hypokalemia 9.9
15 large cell carcinoma 9.9
16 pituitary tumors 9.9
17 rare tumor 9.9
18 duodenum cancer 9.5 MEN1 HRAS
19 gastrointestinal system benign neoplasm 9.5 MEN1 HRAS
20 small intestine cancer 9.4 MEN1 HRAS
21 cell type benign neoplasm 9.4 MEN1 HRAS
22 endocrine gland cancer 9.3 MEN1 HRAS
23 thyroid cancer, nonmedullary, 2 9.1 MEN1 HRAS

Graphical network of the top 20 diseases related to Thymic Neuroendocrine Tumor:



Diseases related to Thymic Neuroendocrine Tumor

Symptoms & Phenotypes for Thymic Neuroendocrine Tumor

Human phenotypes related to Thymic Neuroendocrine Tumor:

59 32 (show all 24)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 neoplasm of the thymus 59 32 obligate (100%) Obligate (100%) HP:0100521
2 mediastinal lymphadenopathy 59 32 hallmark (90%) Very frequent (99-80%) HP:0100721
3 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
4 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
5 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
6 carcinoid tumor 59 32 frequent (33%) Frequent (79-30%) HP:0100570
7 increased circulating acth level 59 32 frequent (33%) Frequent (79-30%) HP:0003154
8 increased circulating cortisol level 59 32 frequent (33%) Frequent (79-30%) HP:0003118
9 abnormal breath sound 59 32 frequent (33%) Frequent (79-30%) HP:0030829
10 prominent veins on trunk 59 32 frequent (33%) Frequent (79-30%) HP:0007457
11 abnormal vena cava morphology 59 32 frequent (33%) Frequent (79-30%) HP:0005345
12 chronic noninfectious lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002730
13 osteopenia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000938
14 hypercalcemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0003072
15 pituitary prolactin cell adenoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0006767
16 pituitary null cell adenoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0011761
17 prolactin excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000870
18 primary hyperparathyroidism 59 32 occasional (7.5%) Occasional (29-5%) HP:0008200
19 calcium nephrolithiasis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004724
20 pancreatic islet cell adenoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0008261
21 neuroendocrine neoplasm 59 Obligate (100%)
22 pituitary adenoma 59 Occasional (29-5%)
23 abnormality of the mediastinum 59 Very frequent (99-80%)
24 neoplasm of the endocrine system 59 Frequent (79-30%)

GenomeRNAi Phenotypes related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.61 HRAS PAK1
2 Decreased viability GR00221-A-1 9.61 HRAS
3 Decreased viability GR00221-A-2 9.61 HRAS PAK1
4 Decreased viability GR00221-A-3 9.61 HRAS
5 Decreased viability GR00301-A 9.61 PAK1
6 Decreased viability GR00402-S-2 9.61 HRAS PAK1
7 Increased cell migration GR00055-A-3 8.62 HRAS PAK1

Drugs & Therapeutics for Thymic Neuroendocrine Tumor

Search Clinical Trials , NIH Clinical Center for Thymic Neuroendocrine Tumor

Genetic Tests for Thymic Neuroendocrine Tumor

Anatomical Context for Thymic Neuroendocrine Tumor

MalaCards organs/tissues related to Thymic Neuroendocrine Tumor:

41
Pituitary, Thymus, Pancreatic Islet

Publications for Thymic Neuroendocrine Tumor

Articles related to Thymic Neuroendocrine Tumor:

(show all 24)
# Title Authors PMID Year
1
The tumor doubling time is a useful parameter for predicting the histological type of thymic epithelial tumors. 38
31134370 2019
2
[Multiple Endocrine Neoplasia]. 38
31296813 2019
3
ACTH-producing thymic neuroendocrine tumor initially presenting as psychosis: A case report and literature review. 38
31187563 2019
4
Capecitabine and Temozolomide as a Promising Therapy for Advanced Thymic Atypical Carcinoid. 38
30413666 2019
5
A unique case of ectopic Cushing's syndrome from a thymic neuroendocrine carcinoma. 38
30802210 2019
6
Capecitabine and Celecoxib as a Promising Therapy for Thymic Neoplasms. 38
28654574 2018
7
JLCS medical practice guidelines for thymic tumors: summary of recommendations. 38
29036455 2017
8
Whole exome sequencing of thymic neuroendocrine tumor with ectopic ACTH syndrome. 38
27913610 2017
9
[Thymic neuroendocrine tumor: about a case and review of the literature]. 38
28451004 2017
10
Invasive atypical thymic carcinoid: three case reports and literature review. 38
27785065 2016
11
Thymic Origin Neuroendocrine Carcinoma Metastasizing to the Orbit in an Otherwise Asymptomatic Patient. 38
25794021 2016
12
Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors. 38
26317915 2015
13
Primary and metastatic parathyroid malignancies: a rare or underdiagnosed condition? 38
25490272 2015
14
[Thymic neuroendocrine carcinoma with Pompe's disease of the adult]. 38
26502468 2015
15
Ectopic ACTH syndrome caused by desmopressin-responsive thymic neuroendocrine tumor. 38
25819222 2015
16
Ectopic Cushing syndrome associated with thymic carcinoid tumor as the first presentation of MEN1 syndrome-report of a family with MEN1 gene mutation. 38
24218143 2014
17
[Additional external radiotherapy to multiple metastases originating from thymic neuroendocrine tumor following peptide receptor radionuclide therapy: a case report]. 38
25011199 2014
18
Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome. 38
23676563 2013
19
A giant neuroendocrine tumor of the thymus gland causing superior vena cava syndrome. 38
22644816 2012
20
Occult ectopic adrenocorticotropic hormone secretion: diagnostic dilemma and infective consequence. 38
24765481 2012
21
Cushing syndrome secondary to a thymic carcinoid tumor due to multiple endocrine neoplasia type 1. 38
21550948 2011
22
Interpretation of the post-surgical Somatostatin Receptor Scintigram of a Primary Neuroendocrine Tumor of the Thymus: a case report and literature review. 38
15788105 2005
23
[Thymic neuroendocrine tumor: three cases in our practice]. 38
15270528 2004
24
Thymic neuroendocrine tumor (thymic carcinoid): a clinicopathologic study in 15 patients. 38
10086551 1999

Variations for Thymic Neuroendocrine Tumor

Expression for Thymic Neuroendocrine Tumor

Search GEO for disease gene expression data for Thymic Neuroendocrine Tumor.

Pathways for Thymic Neuroendocrine Tumor

Pathways related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.18 PAK1 HRAS
2
Show member pathways
12.15 PAK1 HRAS
3
Show member pathways
12.08 PAK1 HRAS
4
Show member pathways
12.03 PAK1 HRAS
5
Show member pathways
12.02 PAK1 HRAS
6
Show member pathways
12.02 PAK1 HRAS
7
Show member pathways
11.98 PAK1 HRAS
8
Show member pathways
11.97 PAK1 HRAS
9
Show member pathways
11.96 PAK1 HRAS
10
Show member pathways
11.91 PAK1 HRAS
11
Show member pathways
11.89 PAK1 HRAS
12 11.86 PAK1 HRAS
13
Show member pathways
11.81 PAK1 HRAS
14 11.78 PAK1 HRAS
15
Show member pathways
11.75 PAK1 HRAS
16
Show member pathways
11.72 PAK1 HRAS
17 11.69 PAK1 HRAS
18
Show member pathways
11.61 PAK1 HRAS
19
Show member pathways
11.5 PAK1 HRAS
20
Show member pathways
11.29 PAK1 HRAS
21 11.14 PAK1 HRAS
22
Show member pathways
11.06 PAK1 HRAS
23 11.01 PAK1 HRAS
24 10.88 PAK1 HRAS
25 10.6 PAK1 HRAS
26 10.6 PAK1 HRAS
27 9.97 PAK1 HRAS

GO Terms for Thymic Neuroendocrine Tumor

Biological processes related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.4 PAK1 HRAS
2 positive regulation of protein phosphorylation GO:0001934 9.37 PAK1 HRAS
3 T cell receptor signaling pathway GO:0050852 9.32 PAK1 HRAS
4 ephrin receptor signaling pathway GO:0048013 9.26 PAK1 HRAS
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.16 PAK1 HRAS
6 positive regulation of protein targeting to membrane GO:0090314 8.96 PAK1 HRAS
7 MAPK cascade GO:0000165 8.8 PAK1 MEN1 HRAS

Sources for Thymic Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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