MCID: THY108
MIFTS: 36

Thymic Neuroendocrine Tumor

Categories: Endocrine diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Thymic Neuroendocrine Tumor

Summaries for Thymic Neuroendocrine Tumor

MalaCards based summary : Thymic Neuroendocrine Tumor is related to neuroendocrine tumor and multiple endocrine neoplasia, type i. An important gene associated with Thymic Neuroendocrine Tumor is MEN1 (Menin 1), and among its related pathways/superpathways are Immune response Role of DAP12 receptors in NK cells and Prolactin Signaling Pathway. The drugs insulin and Mitogens have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thymus and pancreatic islet, and related phenotypes are osteopenia and weight loss

Related Diseases for Thymic Neuroendocrine Tumor

Diseases related to Thymic Neuroendocrine Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 neuroendocrine tumor 10.3
2 multiple endocrine neoplasia, type i 9.9
3 multiple endocrine neoplasia 9.9
4 paraganglioma 9.8
5 thymus cancer 9.8
6 carcinoid syndrome 9.8
7 duodenum cancer 9.3 HRAS MEN1
8 cell type benign neoplasm 9.2 HRAS MEN1
9 endocrine gland cancer 9.1 HRAS MEN1
10 thyroid cancer, nonmedullary, 2 8.9 HRAS MEN1

Graphical network of the top 20 diseases related to Thymic Neuroendocrine Tumor:



Diseases related to Thymic Neuroendocrine Tumor

Symptoms & Phenotypes for Thymic Neuroendocrine Tumor

Human phenotypes related to Thymic Neuroendocrine Tumor:

59 32 (show all 25)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 osteopenia 59 32 occasional (7.5%) Occasional (29-5%) HP:0000938
2 weight loss 59 32 frequent (33%) Frequent (79-30%) HP:0001824
3 chest pain 59 32 frequent (33%) Frequent (79-30%) HP:0100749
4 carcinoid tumor 59 32 frequent (33%) Frequent (79-30%) HP:0100570
5 hypercalcemia 59 32 occasional (7.5%) Occasional (29-5%) HP:0003072
6 pituitary prolactin cell adenoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0006767
7 pituitary null cell adenoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0011761
8 cough 59 32 frequent (33%) Frequent (79-30%) HP:0012735
9 mediastinal lymphadenopathy 59 32 hallmark (90%) Very frequent (99-80%) HP:0100721
10 increased circulating acth level 59 32 frequent (33%) Frequent (79-30%) HP:0003154
11 neoplasm of the thymus 59 32 obligate (100%) Obligate (100%) HP:0100521
12 increased circulating cortisol level 59 32 frequent (33%) Frequent (79-30%) HP:0003118
13 prolactin excess 59 32 occasional (7.5%) Occasional (29-5%) HP:0000870
14 prominent veins on trunk 59 32 frequent (33%) Frequent (79-30%) HP:0007457
15 abnormal breath sound 59 32 frequent (33%) Frequent (79-30%) HP:0030829
16 chronic noninfectious lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002730
17 primary hyperparathyroidism 59 32 occasional (7.5%) Occasional (29-5%) HP:0008200
18 calcium nephrolithiasis 59 32 occasional (7.5%) Occasional (29-5%) HP:0004724
19 pancreatic islet cell adenoma 59 32 occasional (7.5%) Occasional (29-5%) HP:0008261
20 neuroendocrine neoplasm 59 Obligate (100%)
21 pituitary adenoma 59 Occasional (29-5%)
22 abnormality of the mediastinum 59 Very frequent (99-80%)
23 abnormality of the vena cava 59 Frequent (79-30%)
24 neoplasm of the endocrine system 59 Frequent (79-30%)
25 abnormal vena cava morphology 32 frequent (33%) HP:0005345

GenomeRNAi Phenotypes related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.61 PAK1 HRAS
2 Decreased viability GR00221-A-1 9.61 HRAS
3 Decreased viability GR00221-A-2 9.61 PAK1 HRAS
4 Decreased viability GR00221-A-3 9.61 HRAS
5 Decreased viability GR00301-A 9.61 PAK1
6 Decreased viability GR00402-S-2 9.61 PAK1 HRAS
7 Increased cell migration GR00055-A-3 8.62 HRAS PAK1

Drugs & Therapeutics for Thymic Neuroendocrine Tumor

Drugs for Thymic Neuroendocrine Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 insulin Phase 2
2 Mitogens Phase 2
3 Insulin, Globin Zinc Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Multicenter Phase II Study of IMC-A12 in Patients With Thymoma and Thymic Carcinoma Who Have Been Previously Treated With Chemotherapy Completed NCT00965250 Phase 2 IMC-12

Search NIH Clinical Center for Thymic Neuroendocrine Tumor

Genetic Tests for Thymic Neuroendocrine Tumor

Anatomical Context for Thymic Neuroendocrine Tumor

MalaCards organs/tissues related to Thymic Neuroendocrine Tumor:

41
Pituitary, Thymus, Pancreatic Islet

Publications for Thymic Neuroendocrine Tumor

Articles related to Thymic Neuroendocrine Tumor:

# Title Authors Year
1
Clinical Features and Prognosis of Thymic Neuroendocrine Tumors Associated with Multiple Endocrine Neoplasia Type 1: A Single Center Study, Systematic Review, and Meta-analysis. ( 28940393 )
2017
2
Whole exome sequencing of thymic neuroendocrine tumor with ectopic ACTH syndrome. ( 27913610 )
2017
3
Ectopic ACTH syndrome caused by desmopressin-responsive thymic neuroendocrine tumor. ( 25819222 )
2015
4
Impact of Positive Nodal Metastases in Patients with Thymic Carcinoma and Thymic Neuroendocrine Tumors. ( 26317915 )
2015
5
Thymic neuroendocrine tumors (paraganglioma and carcinoid tumors): a comparative immunohistochemical study of 46 cases. ( 25294372 )
2014
6
Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome. ( 23676563 )
2013
7
p21-activated kinase 3 is overexpressed in thymic neuroendocrine tumors (carcinoids) with ectopic ACTH syndrome and participates in cell migration. ( 20960100 )
2010
8
Thymic neuroendocrine tumors in multiple endocrine neoplasia type 1: a comparative study on 21 cases among a series of 761 MEN1 from the GTE (Groupe des Tumeurs Endocrines). ( 19294466 )
2009
9
p53, cellular proliferation, and apoptosis-related factors in thymic neuroendocrine tumors. ( 14631373 )
2004
10
Thymic neuroendocrine tumor (thymic carcinoid): a clinicopathologic study in 15 patients. ( 10086551 )
1999

Variations for Thymic Neuroendocrine Tumor

Expression for Thymic Neuroendocrine Tumor

Search GEO for disease gene expression data for Thymic Neuroendocrine Tumor.

Pathways for Thymic Neuroendocrine Tumor

Pathways related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.09 HRAS PAK1
2
Show member pathways
12.06 HRAS PAK1
3
Show member pathways
12.05 HRAS PAK1
4
Show member pathways
12.02 HRAS PAK1
5
Show member pathways
12 HRAS PAK1
6
Show member pathways
11.99 HRAS PAK1
7
Show member pathways
11.98 HRAS PAK1
8
Show member pathways
11.95 HRAS PAK1
9
Show member pathways
11.95 HRAS PAK1
10
Show member pathways
11.93 HRAS PAK1
11
Show member pathways
11.88 HRAS PAK1
12 11.83 HRAS PAK1
13 11.75 HRAS PAK1
14
Show member pathways
11.75 HRAS PAK1
15
Show member pathways
11.73 HRAS PAK1
16 11.69 HRAS PAK1
17
Show member pathways
11.61 HRAS PAK1
18
Show member pathways
11.5 HRAS PAK1
19
Show member pathways
11.45 HRAS PAK1
20
Show member pathways
11.29 HRAS PAK1
21 11 HRAS PAK1
22 10.88 HRAS PAK1
23 10.6 HRAS PAK1
24 9.97 HRAS PAK1

GO Terms for Thymic Neuroendocrine Tumor

Biological processes related to Thymic Neuroendocrine Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell migration GO:0030335 9.4 HRAS PAK1
2 Fc-epsilon receptor signaling pathway GO:0038095 9.37 HRAS PAK1
3 T cell receptor signaling pathway GO:0050852 9.32 HRAS PAK1
4 positive regulation of protein phosphorylation GO:0001934 9.26 HRAS PAK1
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.16 HRAS PAK1
6 ephrin receptor signaling pathway GO:0048013 8.96 HRAS PAK1
7 MAPK cascade GO:0000165 8.8 HRAS MEN1 PAK1

Sources for Thymic Neuroendocrine Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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