MCID: THY018
MIFTS: 25

Thymus Clear Cell Carcinoma

Categories: Cancer diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Thymus Clear Cell Carcinoma

MalaCards integrated aliases for Thymus Clear Cell Carcinoma:

Name: Thymus Clear Cell Carcinoma 12 15
Clear Cell Carcinoma of the Thymus 12
Thymic Clear Cell Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8137
NCIt 49 C6462
UMLS 71 C1333069

Summaries for Thymus Clear Cell Carcinoma

MalaCards based summary : Thymus Clear Cell Carcinoma, also known as clear cell carcinoma of the thymus, is related to thymic carcinoma and thymoma, and has symptoms including dyspnea and chest pain. An important gene associated with Thymus Clear Cell Carcinoma is PAX8 (Paired Box 8), and among its related pathways/superpathways is Preimplantation Embryo. Affiliated tissues include thymus, and related phenotypes are no phenotypic analysis and normal

Related Diseases for Thymus Clear Cell Carcinoma

Diseases in the Thymus Large Cell Carcinoma family:

Thymus Small Cell Carcinoma Thymus Clear Cell Carcinoma

Diseases related to Thymus Clear Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 354)
# Related Disease Score Top Affiliating Genes
1 thymic carcinoma 29.1 PAX8 NKX2-1 KRT7 KRT20 KIT CD5
2 thymoma 29.1 TTN NKX2-1 KRT7 KIT CD5 CALB2
3 thymic epithelial tumor 10.5 KIT CD5
4 spindle epithelial tumor with thymus-like differentiation tumor 10.5 KIT CD5
5 primary congenital hypothyroidism 10.5 PAX8 NKX2-1
6 thyroid malformation 10.5 PAX8 NKX2-1
7 type c thymoma 10.5 KIT CD5
8 athyreosis 10.5 PAX8 NKX2-1
9 ovarian mixed germ cell neoplasm 10.5 PAX8 KIT
10 bladder lymphoma 10.5 KRT20 CD5
11 nonmucinous bronchioloalveolar adenocarcinoma 10.4 NKX2-1 KRT20
12 rare tumor 10.4 KIT EWSR1
13 lung acinar adenocarcinoma 10.4 NKX2-1 KRT20
14 ectopic thymus 10.4 NKX2-1 CD5
15 rete testis adenoma 10.4 PAX8 CALB2
16 cerebellar angioblastoma 10.4 KIT EWSR1
17 ovarian fibrothecoma 10.4 KIT CALB2
18 cutaneous ganglioneuroma 10.4 KRT20 KIT
19 extraskeletal ewing sarcoma 10.4 NKX2-1 EWSR1
20 nephrogenic adenoma 10.4 PAX8 KRT7
21 epithelial malignant thymoma 10.4 TTN CD5
22 spindle cell thymoma 10.4 CD5 CALB2
23 mixed germ cell-sex cord neoplasm 10.4 KIT CALB2
24 dendritic cell thymoma 10.4 TTN CD5
25 malignant anus melanoma 10.3 MLANA KIT
26 benign fibrous mesothelioma 10.3 KIT CALB2
27 malignant dermis tumor 10.3 MLANA KIT
28 malignant epithelial mesothelioma 10.3 PTGER4 CALB2
29 malignant skin fibrous histiocytoma 10.3 MLANA KIT
30 benign perivascular tumor 10.3 MLANA KIT
31 wolffian duct adenoma 10.3 PAX8 KRT7
32 bladder benign neoplasm 10.3 PAX8 KRT7
33 vulvar melanoma 10.3 MLANA KIT
34 ovarian gonadoblastoma 10.3 KIT CALB2
35 sclerosing hemangioma 10.3 NKX2-1 KRT7
36 renal pelvis adenocarcinoma 10.3 PAX8 KRT7
37 cervical adenoid cystic carcinoma 10.3 KRT7 KIT
38 small intestine leiomyoma 10.3 MLANA KIT
39 thyroid angiosarcoma 10.3 PAX8 NKX2-1 KRT20
40 hepatic angiomyolipoma 10.3 MLANA KIT
41 ovarian cystic teratoma 10.3 NKX2-1 MLANA
42 lung adenoid cystic carcinoma 10.3 KRT7 KIT
43 urethral diverticulum 10.3 PAX8 KRT7
44 adenoid basal cell carcinoma 10.3 KRT7 KIT
45 urethral villous adenoma 10.3 KRT7 KRT20
46 fallopian tube endometrioid adenocarcinoma 10.3 PAX8 CALB2
47 pigmented basal cell carcinoma 10.3 PTGER4 MLANA
48 intrahepatic bile duct adenoma 10.2 KRT7 KRT20
49 bile duct adenoma 10.2 KRT7 KRT20
50 atrophic vulva 10.2 KRT7 KRT20

Graphical network of the top 20 diseases related to Thymus Clear Cell Carcinoma:



Diseases related to Thymus Clear Cell Carcinoma

Symptoms & Phenotypes for Thymus Clear Cell Carcinoma

UMLS symptoms related to Thymus Clear Cell Carcinoma:


dyspnea, chest pain

MGI Mouse Phenotypes related to Thymus Clear Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.43 CD5 GATA3 KIT MLANA NKX2-1 PAX8
2 normal MP:0002873 9.28 CALB2 CD5 CDX2 GATA3 KIT NKX2-1

Drugs & Therapeutics for Thymus Clear Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Thymus Clear Cell Carcinoma

Genetic Tests for Thymus Clear Cell Carcinoma

Anatomical Context for Thymus Clear Cell Carcinoma

MalaCards organs/tissues related to Thymus Clear Cell Carcinoma:

40
Thymus

Publications for Thymus Clear Cell Carcinoma

Articles related to Thymus Clear Cell Carcinoma:

# Title Authors PMID Year
1
Primary clear cell carcinoma of the thymus and literature comparison of features. 61
29588619 2018
2
Diagnosis of thymic clear cell carcinoma by cytology. 61
24175107 2013
3
Thymic clear cell carcinoma. 61
20155348 2010

Variations for Thymus Clear Cell Carcinoma

Expression for Thymus Clear Cell Carcinoma

Search GEO for disease gene expression data for Thymus Clear Cell Carcinoma.

Pathways for Thymus Clear Cell Carcinoma

Pathways related to Thymus Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.58 NKX2-1 GATA3 CDX2

GO Terms for Thymus Clear Cell Carcinoma

Biological processes related to Thymus Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.5 KRT7 KRT5 KRT20
2 anatomical structure formation involved in morphogenesis GO:0048646 9.4 NKX2-1 GATA3
3 embryonic hemopoiesis GO:0035162 9.37 KIT GATA3
4 mesonephros development GO:0001823 9.26 PAX8 GATA3
5 otic vesicle development GO:0071599 9.16 PAX8 GATA3
6 positive regulation of thyroid hormone generation GO:2000611 8.96 PAX8 GATA3
7 mast cell differentiation GO:0060374 8.62 KIT GATA3

Sources for Thymus Clear Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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