MCID: THY018
MIFTS: 27

Thymus Clear Cell Carcinoma

Categories: Cancer diseases, Endocrine diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Thymus Clear Cell Carcinoma

MalaCards integrated aliases for Thymus Clear Cell Carcinoma:

Name: Thymus Clear Cell Carcinoma 12 15
Clear Cell Carcinoma of the Thymus 12
Thymic Clear Cell Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8137
NCIt 49 C6462
UMLS 71 C1333069

Summaries for Thymus Clear Cell Carcinoma

MalaCards based summary : Thymus Clear Cell Carcinoma, also known as clear cell carcinoma of the thymus, is related to thymic carcinoma and thymoma, and has symptoms including dyspnea and chest pain. An important gene associated with Thymus Clear Cell Carcinoma is PAX8 (Paired Box 8), and among its related pathways/superpathways is Preimplantation Embryo. Affiliated tissues include thymus, breast and lung, and related phenotypes are no phenotypic analysis and normal

Related Diseases for Thymus Clear Cell Carcinoma

Diseases in the Thymus Large Cell Carcinoma family:

Thymus Small Cell Carcinoma Thymus Clear Cell Carcinoma

Diseases related to Thymus Clear Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 353)
# Related Disease Score Top Affiliating Genes
1 thymic carcinoma 29.1 PAX8 NKX2-1 KRT7 KRT20 KIT CD5
2 thymoma 29.1 TTN NKX2-1 KRT7 KIT CD5 CALB2
3 thymic epithelial tumor 10.5 KIT CD5
4 spindle epithelial tumor with thymus-like differentiation tumor 10.5 KIT CD5
5 primary congenital hypothyroidism 10.5 PAX8 NKX2-1
6 type c thymoma 10.5 KIT CD5
7 trachea adenoid cystic carcinoma 10.5 NKX2-1 KIT
8 thyroid malformation 10.5 PAX8 NKX2-1
9 athyreosis 10.5 PAX8 NKX2-1
10 bladder lymphoma 10.5 KRT20 CD5
11 ectopic thymus 10.4 NKX2-1 CD5
12 rare tumor 10.4 KIT EWSR1
13 nonmucinous bronchioloalveolar adenocarcinoma 10.4 NKX2-1 KRT20
14 rete testis adenoma 10.4 PAX8 CALB2
15 ovarian fibrothecoma 10.4 KIT CALB2
16 myxoid liposarcoma of the ovary 10.4 EWSR1 CALB2
17 liposarcoma of the ovary 10.4 EWSR1 CALB2
18 nephrogenic adenoma 10.4 PAX8 KRT7
19 epithelial malignant thymoma 10.4 TTN CD5
20 spindle cell thymoma 10.4 CD5 CALB2
21 cutaneous ganglioneuroma 10.4 KRT20 KIT
22 extraskeletal ewing sarcoma 10.4 NKX2-1 EWSR1
23 hypothyroidism, congenital, nongoitrous, 2 10.4 PAX8 NKX2-1
24 mixed germ cell-sex cord neoplasm 10.4 KIT CALB2
25 dendritic cell thymoma 10.4 TTN CD5
26 liver leiomyoma 10.4 KIT CALB2
27 benign struma ovarii 10.4 PAX8 NKX2-1
28 vagina leiomyosarcoma 10.4 MLANA KIT
29 malignant anus melanoma 10.3 MLANA KIT
30 ovarian mesodermal adenosarcoma 10.3 PAX8 KRT7
31 peritoneal serous adenocarcinoma 10.3 PTGER4 CALB2
32 thyroid gland anaplastic carcinoma 10.3 PAX8 NKX2-1
33 malignant choroid melanoma 10.3 MLANA CD5
34 small intestine leiomyoma 10.3 MLANA KIT
35 ovarian cystic teratoma 10.3 NKX2-1 MLANA
36 wolffian duct adenoma 10.3 PAX8 KRT7
37 breast hemangiopericytoma 10.3 KRT7 KIT
38 malignant dermis tumor 10.3 MLANA KIT
39 sclerosing hemangioma 10.3 NKX2-1 KRT7
40 renal pelvis adenocarcinoma 10.3 PAX8 KRT7
41 cellular myxoid liposarcoma 10.3 KIT EWSR1
42 cervical adenoid cystic carcinoma 10.3 KRT7 KIT
43 malignant skin fibrous histiocytoma 10.3 MLANA KIT
44 vulvar melanoma 10.3 MLANA KIT
45 urethral diverticulum 10.3 PAX8 KRT7
46 adenoid basal cell carcinoma 10.3 KRT7 KIT
47 biphasic synovial sarcoma 10.3 EWSR1 CALB2
48 solid adenocarcinoma with mucin production 10.3 NKX2-1 KRT7
49 fallopian tube endometrioid adenocarcinoma 10.3 PAX8 CALB2
50 urethral villous adenoma 10.3 KRT7 KRT20

Graphical network of the top 20 diseases related to Thymus Clear Cell Carcinoma:



Diseases related to Thymus Clear Cell Carcinoma

Symptoms & Phenotypes for Thymus Clear Cell Carcinoma

UMLS symptoms related to Thymus Clear Cell Carcinoma:


dyspnea, chest pain

MGI Mouse Phenotypes related to Thymus Clear Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.5 CD5 GATA3 KIT KRT5 MLANA NKX2-1
2 normal MP:0002873 9.28 CALB2 CD5 CDX2 GATA3 KIT NKX2-1

Drugs & Therapeutics for Thymus Clear Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Thymus Clear Cell Carcinoma

Genetic Tests for Thymus Clear Cell Carcinoma

Anatomical Context for Thymus Clear Cell Carcinoma

MalaCards organs/tissues related to Thymus Clear Cell Carcinoma:

40
Thymus, Breast, Lung, Colon, Thyroid, Ovary, Kidney

Publications for Thymus Clear Cell Carcinoma

Articles related to Thymus Clear Cell Carcinoma:

# Title Authors PMID Year
1
Primary clear cell carcinoma of the thymus and literature comparison of features. 61
29588619 2018
2
Diagnosis of thymic clear cell carcinoma by cytology. 61
24175107 2013
3
Thymic clear cell carcinoma. 61
20155348 2010

Variations for Thymus Clear Cell Carcinoma

Expression for Thymus Clear Cell Carcinoma

Search GEO for disease gene expression data for Thymus Clear Cell Carcinoma.

Pathways for Thymus Clear Cell Carcinoma

Pathways related to Thymus Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.58 NKX2-1 GATA3 CDX2

GO Terms for Thymus Clear Cell Carcinoma

Biological processes related to Thymus Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.5 KRT7 KRT5 KRT20
2 anatomical structure formation involved in morphogenesis GO:0048646 9.4 NKX2-1 GATA3
3 embryonic hemopoiesis GO:0035162 9.37 KIT GATA3
4 mesonephros development GO:0001823 9.26 PAX8 GATA3
5 otic vesicle development GO:0071599 9.16 PAX8 GATA3
6 positive regulation of thyroid hormone generation GO:2000611 8.96 PAX8 GATA3
7 mast cell differentiation GO:0060374 8.62 KIT GATA3

Sources for Thymus Clear Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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