MCID: THY018
MIFTS: 26

Thymus Clear Cell Carcinoma

Categories: Cancer diseases, Immune diseases, Neuronal diseases

Aliases & Classifications for Thymus Clear Cell Carcinoma

MalaCards integrated aliases for Thymus Clear Cell Carcinoma:

Name: Thymus Clear Cell Carcinoma 12 15
Clear Cell Carcinoma of the Thymus 12
Thymic Clear Cell Carcinoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8137
NCIt 50 C6462
UMLS 71 C1333069

Summaries for Thymus Clear Cell Carcinoma

MalaCards based summary : Thymus Clear Cell Carcinoma, also known as clear cell carcinoma of the thymus, is related to thymic carcinoma and thymoma, and has symptoms including dyspnea and chest pain. An important gene associated with Thymus Clear Cell Carcinoma is PAX8 (Paired Box 8), and among its related pathways/superpathways are Hematopoietic cell lineage and Preimplantation Embryo. Affiliated tissues include thymus, and related phenotypes are growth/size/body region and normal

Related Diseases for Thymus Clear Cell Carcinoma

Diseases in the Thymus Large Cell Carcinoma family:

Thymus Small Cell Carcinoma Thymus Clear Cell Carcinoma

Diseases related to Thymus Clear Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 260)
# Related Disease Score Top Affiliating Genes
1 thymic carcinoma 30.0 PAX8 NKX2-1 KRT20 KIT CD5 CALB2
2 thymoma 29.5 TTN NKX2-1 KIT DNTT CD5 CALB2
3 combined thymoma 10.4 PAX8 CD5
4 thymic epithelial tumor 10.4 KIT CD5
5 primary congenital hypothyroidism 10.4 PAX8 NKX2-1
6 ovarian mixed germ cell neoplasm 10.4 PAX8 KIT
7 type c thymoma 10.4 KIT CD5
8 thyroid malformation 10.4 PAX8 NKX2-1
9 athyreosis 10.4 PAX8 NKX2-1
10 small intestinal sarcoma 10.4 KIT EWSR1
11 bladder benign neoplasm 10.4 PAX8 KRT20
12 nephrogenic adenoma of urinary bladder 10.4 PAX8 KRT20
13 extragonadal seminoma 10.4 NUTM1 KIT
14 bladder lymphoma 10.4 KRT20 CD5
15 ectopic thymus 10.3 NKX2-1 CD5
16 ovarian large-cell neuroendocrine carcinoma 10.3 PAX8 KRT20
17 rare tumor 10.3 KIT EWSR1
18 nonmucinous bronchioloalveolar adenocarcinoma 10.3 NKX2-1 KRT20
19 jejunal neoplasm 10.3 KRT20 KIT
20 intratubular embryonal carcinoma 10.3 KRT20 KIT
21 small cell carcinoma of the bladder 10.3 NKX2-1 KRT20
22 sarcomatous intrahepatic cholangiocarcinoma 10.3 NKX2-1 KIT
23 cutaneous ganglioneuroma 10.3 KRT20 KIT
24 rete testis adenoma 10.3 PAX8 CALB2
25 epithelial malignant thymoma 10.3 TTN CD5
26 ovarian fibrothecoma 10.3 KIT CALB2
27 dendritic cell thymoma 10.3 TTN CD5
28 biphasic synovial sarcoma 10.3 PAX8 EWSR1
29 benign fibrous mesothelioma 10.3 KIT CALB2
30 malignant anus melanoma 10.3 MLANA KIT
31 malignant dermis tumor 10.3 MLANA KIT
32 malignant skin fibrous histiocytoma 10.3 MLANA KIT
33 benign perivascular tumor 10.3 MLANA KIT
34 lung sarcomatoid carcinoma 10.3 NKX2-1 CALB2
35 malignant epithelial mesothelioma 10.3 PTGER4 CALB2
36 vulvar melanoma 10.3 MLANA KIT
37 small intestine leiomyoma 10.3 MLANA KIT
38 squamous papillomatosis 10.2 PTGER4 KRT20
39 malignant choroid melanoma 10.2 MLANA CD5
40 bartholin's gland carcinoma 10.2 PAX8 CDX2
41 skin sarcoma 10.2 MLANA KIT
42 endosalpingiosis 10.2 PAX8 CALB2
43 ovarian seromucinous carcinoma 10.2 PAX8 CDX2
44 ovarian germ cell teratoma 10.2 NKX2-1 CALB2
45 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.2 PAX8 NKX2-1
46 ovarian gonadoblastoma 10.2 KIT CALB2
47 ovarian cystic teratoma 10.2 NKX2-1 MLANA
48 benign struma ovarii 10.2 PAX8 NKX2-1
49 retroperitoneal sarcoma 10.2 MLANA KIT
50 thyroid angiosarcoma 10.2 PAX8 NKX2-1 KRT20

Graphical network of the top 20 diseases related to Thymus Clear Cell Carcinoma:



Diseases related to Thymus Clear Cell Carcinoma

Symptoms & Phenotypes for Thymus Clear Cell Carcinoma

UMLS symptoms related to Thymus Clear Cell Carcinoma:


dyspnea, chest pain

MGI Mouse Phenotypes related to Thymus Clear Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10 CD5 CDX2 DNTT GATA3 KIT KRT5
2 normal MP:0002873 9.65 CALB2 CD5 CDX2 DNTT GATA3 KIT
3 no phenotypic analysis MP:0003012 9.63 CD5 GATA3 KIT MLANA NKX2-1 PAX8
4 skeleton MP:0005390 9.23 CDX2 DNTT GATA3 KIT NKX2-1 PAX8

Drugs & Therapeutics for Thymus Clear Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Thymus Clear Cell Carcinoma

Genetic Tests for Thymus Clear Cell Carcinoma

Anatomical Context for Thymus Clear Cell Carcinoma

MalaCards organs/tissues related to Thymus Clear Cell Carcinoma:

40
Thymus

Publications for Thymus Clear Cell Carcinoma

Articles related to Thymus Clear Cell Carcinoma:

# Title Authors PMID Year
1
Primary clear cell carcinoma of the thymus and literature comparison of features. 61
29588619 2018
2
Diagnosis of thymic clear cell carcinoma by cytology. 61
24175107 2013
3
Thymic clear cell carcinoma. 61
20155348 2010

Variations for Thymus Clear Cell Carcinoma

Expression for Thymus Clear Cell Carcinoma

Search GEO for disease gene expression data for Thymus Clear Cell Carcinoma.

Pathways for Thymus Clear Cell Carcinoma

Pathways related to Thymus Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.13 KIT DNTT CD5
2 10.58 NKX2-1 GATA3 CDX2

GO Terms for Thymus Clear Cell Carcinoma

Biological processes related to Thymus Clear Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid gland development GO:0030878 9.4 PAX8 NKX2-1
2 anatomical structure formation involved in morphogenesis GO:0048646 9.37 NKX2-1 GATA3
3 embryonic hemopoiesis GO:0035162 9.32 KIT GATA3
4 mesonephros development GO:0001823 9.26 PAX8 GATA3
5 otic vesicle development GO:0071599 9.16 PAX8 GATA3
6 positive regulation of thyroid hormone generation GO:2000611 8.96 PAX8 GATA3
7 mast cell differentiation GO:0060374 8.62 KIT GATA3

Sources for Thymus Clear Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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