MCID: THY026
MIFTS: 21

Thymus Gland Disease

Categories: Endocrine diseases, Immune diseases

Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease 12 15
Disease of Thymus Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:533
ICD10 33 E32 E32.9
ICD9CM 35 254 254.9
NCIt 50 C26962
UMLS 73 C0154199

Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to thymic dysplasia and ectopic thymus. An important gene associated with Thymus Gland Disease is TFAP2A (Transcription Factor AP-2 Alpha), and among its related pathways/superpathways are Apoptosis and survival Caspase cascade and Apoptosis and Autophagy. Affiliated tissues include thymus, and related phenotypes are embryo and hearing/vestibular/ear

Related Diseases for Thymus Gland Disease

Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 thymic dysplasia 8.8 FOXN1 XAF1 YARS
2 ectopic thymus 8.1 BCL2 FOXN1 OMG TFAP2A

Symptoms & Phenotypes for Thymus Gland Disease

MGI Mouse Phenotypes related to Thymus Gland Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.46 BCL2 FOXN1 TFAP2A YARS
2 hearing/vestibular/ear MP:0005377 9.13 BCL2 FOXN1 TFAP2A
3 pigmentation MP:0001186 8.8 BCL2 FOXN1 TFAP2A

Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

Genetic Tests for Thymus Gland Disease

Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

41
Thymus

Publications for Thymus Gland Disease

Variations for Thymus Gland Disease

Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

Pathways for Thymus Gland Disease

GO Terms for Thymus Gland Disease

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.65 BCL2 XAF1 YARS
2 animal organ morphogenesis GO:0009887 9.46 BCL2 FOXN1
3 axonogenesis GO:0007409 9.43 BCL2 OMG
4 kidney development GO:0001822 9.4 BCL2 TFAP2A
5 hemopoiesis GO:0030097 9.37 BCL2 FOXN1
6 thymus development GO:0048538 9.32 BCL2 FOXN1
7 T cell homeostasis GO:0043029 9.26 BCL2 FOXN1
8 negative regulation of reactive oxygen species metabolic process GO:2000378 9.16 BCL2 TFAP2A
9 lymphocyte homeostasis GO:0002260 8.96 BCL2 FOXN1
10 T cell lineage commitment GO:0002360 8.62 BCL2 FOXN1

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sequence-specific DNA binding GO:0043565 8.8 BCL2 FOXN1 TFAP2A

Sources for Thymus Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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