MCID: THY026
MIFTS: 32

Thymus Gland Disease

Categories: Endocrine diseases, Immune diseases

Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease 12 15
Disease of Thymus Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:533
ICD9CM 34 254 254.9
NCIt 49 C26962
SNOMED-CT 67 20673009
ICD10 32 E32 E32.9
UMLS 71 C0154199

Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to cork-handlers' disease and syphilitic meningitis. An important gene associated with Thymus Gland Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Akt Signaling. Affiliated tissues include thymus, skin and t cells, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Thymus Gland Disease

Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)
# Related Disease Score Top Affiliating Genes
1 cork-handlers' disease 10.7 CD8A CD4
2 syphilitic meningitis 10.7 CD8A CD4
3 thymic epithelial tumor 10.7 KIT CD5
4 spongiotic dermatitis 10.7 CD8A CD4 CCR6
5 mikulicz disease 10.7 ICOSLG CD4 CCR6
6 ventilation pneumonitis 10.7 CD8A CD4
7 pneumonic tularemia 10.7 CD8A CD4 CCR6
8 blastomycosis 10.7 CD8A CD4 CCR6
9 parapsoriasis 10.7 CD8A CD5 CD4
10 spindle epithelial tumor with thymus-like differentiation tumor 10.7 KIT CD5
11 diffuse infiltrative lymphocytosis syndrome 10.7 CD8A CD4
12 central nervous system vasculitis 10.7 CD8A CD4 CCR6
13 autoimmune lymphoproliferative syndrome, type iia 10.7 CD8A CD4
14 nail disorder, nonsyndromic congenital, 1 10.7 CCR6 AIRE
15 chronic conjunctivitis 10.7 ICOSLG CD4 CCR6
16 acute proliferative glomerulonephritis 10.7 ICOSLG CD4 CCR6
17 cardiomyopathy, familial hypertrophic, 9 10.7 TTN CD8A CD4
18 nut allergy 10.7 ICOSLG CD4 CCR6
19 autoimmune peripheral neuropathy 10.7 ICOSLG CD4 AIRE
20 pneumocystosis 10.7 CD8A CD4 CCR6
21 igg4-related disease 10.7 ICOSLG CD4 CCR6
22 autoimmune disease of skin and connective tissue 10.7 ICOSLG CD4 CCR6
23 immunodeficiency with hyper-igm, type 3 10.7 ICOSLG CD8A CD4
24 blepharitis 10.7 CD8A CD4 CCR6
25 acute myocarditis 10.7 H2AC18 CD8A CD4
26 histoplasmosis 10.7 CD8A CD4 CCR6
27 streptococcus pneumonia 10.7 H2AC18 CD8A CD4
28 immune-complex glomerulonephritis 10.6 ICOSLG H2AC18 CD4
29 genital herpes 10.6 CD8A CD4 CCR6
30 scleral disease 10.6 IL2 CD4 CCR6
31 cryptococcosis 10.6 CD8A CD4 CCR6
32 panuveitis 10.6 CD8A CD4 CCR6
33 plasma protein metabolism disease 10.6 CD5 CD4 CCR6
34 autoimmune neuropathy 10.6 ICOSLG CNTNAP2 CD4
35 alopecia universalis congenita 10.6 CD8A CD4 AIRE
36 superficial basal cell carcinoma 10.6 IL2 CD8A CD4
37 oral tuberculosis 10.6 IL2 CD8A CD4
38 thymus clear cell carcinoma 10.6 TTN KIT CD5
39 farmer's lung 10.6 IL2 CD8A CD4
40 tuberculoid leprosy 10.6 IL2 CD4 CCR6
41 bullous skin disease 10.6 ICOSLG CD4 CCR6
42 parotid disease 10.6 TP53 CD8A CD4
43 chromosome 14q11-q22 deletion syndrome 10.6 CD8A CD4
44 middle ear disease 10.6 CD8A CD4 CCR6
45 pneumonic plague 10.6 IL2 CD8A CD4
46 anal squamous cell carcinoma 10.6 TP53 H2AC18 AKT1
47 diabetes mellitus, insulin-dependent, 23 10.6 CD8A CD4
48 chorioretinitis 10.6 IL2 CD8A CD4
49 immunodeficiency 18 10.6 PTPRC CD8A CD4
50 autosomal dominant epilepsy with auditory features 10.6 LGI1 CNTNAP2

Graphical network of the top 20 diseases related to Thymus Gland Disease:



Diseases related to Thymus Gland Disease

Symptoms & Phenotypes for Thymus Gland Disease

MGI Mouse Phenotypes related to Thymus Gland Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.26 AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2 growth/size/body region MP:0005378 10.21 AIRE AKT1 CD4 CNTNAP2 IL2 KIT
3 endocrine/exocrine gland MP:0005379 10.16 AIRE AKT1 AMPH CD4 CD8A IL2
4 immune system MP:0005387 10.15 AIRE AKT1 CCR6 CD4 CD5 CD8A
5 hematopoietic system MP:0005397 10.14 AIRE AKT1 CCR6 CD4 CD5 CD8A
6 nervous system MP:0003631 10.13 AIRE AKT1 AMPH CCR6 CD4 CD5
7 integument MP:0010771 10.02 AKT1 CD4 CD5 CD8A CNTNAP2 KIT
8 no phenotypic analysis MP:0003012 9.76 AIRE CD4 CD5 IL2 KIT MTOR
9 normal MP:0002873 9.7 AIRE AKT1 CCR6 CD4 CD5 CD8A
10 respiratory system MP:0005388 9.23 AIRE AKT1 IL2 KIT MTOR MUSK

Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

Genetic Tests for Thymus Gland Disease

Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

40
Thymus, Skin, T Cells, B Cells, Bone, Lung, Breast

Publications for Thymus Gland Disease

Variations for Thymus Gland Disease

Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

Pathways for Thymus Gland Disease

Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.36 TP53 PTPRC MTOR KIT ICOSLG CD8A
2
Show member pathways
13.31 TP53 MUSK MTOR KIT IL2 CD4
3
Show member pathways
12.54 PTPRC IL2 ICOSLG CD4 AKT1
4
Show member pathways
12.42 PTPRC MTOR IL2 CD8A CD4 AKT1
5
Show member pathways
12.26 PTPRC IL2 ICOSLG CD4 AKT1
6 12.25 TP53 IL2 CD4 AKT1
7
Show member pathways
12.24 PTPRC MTOR CD4 AKT1
8
Show member pathways
12.11 MTOR ICOSLG CD4 AKT1
9 11.93 PTPRC ICOSLG CNTNAP2 CD8A CD4
10
Show member pathways
11.88 MTOR IL2 CD8A CD4
11
Show member pathways
11.84 PTPRC CD8A CD4 AKT1
12 11.79 PTPRC MTOR IL2 AKT1
13 11.79 KIT CD8A CD5 CD4
14 11.72 TP53 IL2 AKT1
15
Show member pathways
11.66 TP53 MTOR AKT1
16 11.64 CD8A CD4 AKT1
17 11.64 PTPRC MTOR CD4 AKT1
18
Show member pathways
11.6 MTOR IL2 AKT1
19 11.59 MTOR IL2 AKT1
20 11.57 TP53 MTOR KIT AKT1
21 11.5 PTPRC KIT IL2 CD8A CD5 CD4
22 11.42 PTPRC KIT IL2 CD8A CD4
23 11.35 PTPRC KIT CD5 CD4
24 11.2 IL2 CD8A AKT1
25 11.14 PTPRC CD8A CD4 AIRE
26 11 PTPRC KIT IL2 CD8A CD4 CCR6

GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.17 PTPRC KIT ICOSLG CD8A CD5 CD4

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10 IL2 CD8A CD4 CCR6 AIRE
2 cytokine-mediated signaling pathway GO:0019221 9.85 TP53 KIT IL2 CD4 AKT1
3 protein autophosphorylation GO:0046777 9.78 MUSK MTOR KIT AKT1
4 positive regulation of cell growth GO:0030307 9.76 LGI1 IL2 AKT1
5 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.73 MUSK KIT CD8A CD4
6 hematopoietic progenitor cell differentiation GO:0002244 9.71 TP53 PTPRC KIT
7 positive regulation of MAPK cascade GO:0043410 9.71 PTPRC MUSK KIT CD4
8 positive regulation of T cell proliferation GO:0042102 9.69 PTPRC IL2 CD4
9 T cell costimulation GO:0031295 9.67 ICOSLG CD5 AKT1
10 positive regulation of protein phosphorylation GO:0001934 9.65 MUSK MTOR IL2 CD4 AKT1
11 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.62 TP53 PTPRC MTOR CD4
12 negative thymic T cell selection GO:0045060 9.6 PTPRC AIRE
13 anoikis GO:0043276 9.59 MTOR AKT1
14 positive regulation of isotype switching to IgG isotypes GO:0048304 9.58 PTPRC IL2
15 negative regulation of cell size GO:0045792 9.57 MTOR AKT1
16 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.56 CD4 AKT1
17 bone marrow development GO:0048539 9.55 TP53 PTPRC
18 regulation of glycogen biosynthetic process GO:0005979 9.52 MTOR AKT1
19 positive regulation of gene expression GO:0010628 9.5 TTN TP53 MUSK MTOR MIR125A KIT
20 T cell activation GO:0042110 9.46 PTPRC ICOSLG CD8A CD4
21 DN2 thymocyte differentiation GO:1904155 9.37 PTPRC CCR6
22 T cell differentiation GO:0030217 8.92 PTPRC KIT IL2 CD4

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TTN TP53 PTPRC MUSK MTOR LGI1
2 identical protein binding GO:0042802 9.8 TTN TP53 MTOR ICOSLG CD4 AKT1
3 enzyme binding GO:0019899 9.55 TTN TP53 CNTNAP2 CD4 AKT1
4 protein kinase binding GO:0019901 9.17 TTN TP53 PTPRC MTOR CD8A CD4

Sources for Thymus Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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