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MCID: THY026
MIFTS: 32

Thymus Gland Disease

Categories: Endocrine diseases, Immune diseases
Genes Tissues Related diseases Pathways
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Aliases & Classifications for Thymus Gland Disease

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MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease 12 15
Disease of Thymus Gland 12

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:533
ICD10 33 E32 E32.9
ICD9CM 35 254 254.9
NCIt 50 C26962
SNOMED-CT 68 20673009
UMLS 73 C0154199
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Summaries for Thymus Gland Disease

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MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to thymic epithelial tumor and dendritic cell thymoma. An important gene associated with Thymus Gland Disease is PIK3R2 (Phosphoinositide-3-Kinase Regulatory Subunit 2), and among its related pathways/superpathways are Pathways in cancer and Downstream signaling events of B Cell Receptor (BCR). Affiliated tissues include thymus, lung and skin, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Thymus Gland Disease

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Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 thymic epithelial tumor 10.2 CD5 KIT
2 dendritic cell thymoma 10.2 CD5 TTN
3 maxillary sinus adenoid cystic carcinoma 10.2 IL2 KIT
4 splenic tuberculosis 10.2 IL2 SMUG1
5 pharynx squamous cell carcinoma 10.2 AKT1 SMUG1
6 prostate lymphoma 10.2 CD5 SMUG1
7 breast lymphoma 10.2 CD5 SMUG1
8 immune system disease 10.1 AIRE IL2 MUSK
9 ectopic thymus 10.1 CD5 OMG
10 mixed type thymoma 10.1 CD5 KIT
11 mediastinal cancer 10.1 CD5 KIT SMUG1
12 pharynx cancer 10.1 AKT1 KIT SMUG1
13 connective tissue cancer 10.1 AKT1 KIT SMUG1
14 ocular melanoma 10.1 IL2 KIT
15 intestinal disease 10.1 AKT1 IL2 SMUG1
16 myasthenia gravis 10.1 AIRE IL2 MUSK TTN
17 lymphoepithelioma-like thymic carcinoma 10.1 CD5 KIT
18 lymphatic system disease 10.1 CD5 IL2 SMUG1 TTN
19 hepatic angiomyolipoma 10.1 KIT MTOR
20 respiratory system disease 10.1 AKT1 IL2 PIK3R2 SMUG1
21 gastrointestinal system cancer 10.0 AKT1 KIT SMUG1
22 autoimmune disease of the nervous system 10.0 IL2 MUSK OMG TTN
23 muscular disease 10.0 AKT1 KIT SMUG1 TTN
24 gastrointestinal system disease 10.0 AKT1 IL2 KIT SMUG1
25 myeloma, multiple 10.0 AKT1 IL2 KIT SMUG1
26 neuromuscular junction disease 10.0 LRP4 MUSK OMG TTN
27 hematologic cancer 10.0 CD5 IL2 KIT MTOR
28 leukocyte disease 9.9 AKT1 CD5 IL2 KIT SMUG1
29 large intestine cancer 9.9 AKT1 IL2 MTOR SMUG1
30 leukemia, acute myeloid 9.7 AKT1 IL2 KIT MTOR
31 thymus cancer 9.1 AMPH CD5 CNTNAP2 DPYSL5 KIT PIK3R2
32 thymoma 9.0 AIRE AKT1 AMPH CD5 DPYSL5 IL2

Graphical network of the top 20 diseases related to Thymus Gland Disease:



Diseases related to Thymus Gland Disease
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Symptoms & Phenotypes for Thymus Gland Disease

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GenomeRNAi Phenotypes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

26 (show all 41)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.37 MTOR MUSK
2 Decreased viability GR00173-A 10.37 MUSK PIK3R2
3 Decreased viability GR00221-A-1 10.37 AKT1 KIT MTOR MUSK PIK3R2
4 Decreased viability GR00221-A-2 10.37 AKT1 PIK3R2 TTN
5 Decreased viability GR00221-A-3 10.37 AKT1
6 Decreased viability GR00221-A-4 10.37 AKT1 MTOR MUSK PIK3R2 TTN
7 Decreased viability GR00301-A 10.37 KIT PIK3R2
8 Decreased viability GR00342-S-1 10.37 MTOR TTN
9 Decreased viability GR00342-S-2 10.37 MTOR
10 Decreased viability GR00342-S-3 10.37 TTN
11 Decreased viability GR00402-S-2 10.37 AKT1 KIT MTOR MUSK PIK3R2 TTN
12 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.96 KIT PIK3R2
13 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.96 MTOR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.96 MTOR PIK3R2
15 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.96 PIK3R2
16 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.96 MUSK
17 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.96 KIT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.96 KIT
19 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.96 AKT1 MTOR
20 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.96 AIRE MUSK
21 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.96 KIT
22 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.96 AKT1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.96 AIRE
24 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.96 MUSK
25 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.96 MUSK PIK3R2
26 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.96 KIT
27 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.96 MUSK
28 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.96 AKT1 KIT MTOR
29 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.96 MUSK
30 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.96 AIRE
31 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.96 AKT1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-57 9.96 PIK3R2
33 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.96 MUSK
34 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.96 AKT1
35 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.96 MTOR
36 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.96 AKT1 MUSK
37 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.96 AIRE
38 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.96 PIK3R2
39 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.96 AIRE AKT1 KIT MTOR MUSK PIK3R2
40 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.96 KIT
41 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.96 KIT

MGI Mouse Phenotypes related to Thymus Gland Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2 cellular MP:0005384 10.07 AKT1 CNTNAP2 IL2 KIT LRP4 MTOR
3 growth/size/body region MP:0005378 10.06 AIRE AKT1 CNTNAP2 IL2 KIT LRP4
4 nervous system MP:0003631 9.93 AIRE AKT1 AMPH CD5 CNTNAP2 DPYSL5
5 neoplasm MP:0002006 9.73 AIRE AKT1 IL2 KIT PIK3R2 SMUG1
6 no phenotypic analysis MP:0003012 9.5 AIRE CD5 IL2 KIT MTOR OMG
7 respiratory system MP:0005388 9.23 AIRE AKT1 IL2 KIT LRP4 MTOR
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Drugs & Therapeutics for Thymus Gland Disease

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Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

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Genetic Tests for Thymus Gland Disease

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Anatomical Context for Thymus Gland Disease

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MalaCards organs/tissues related to Thymus Gland Disease:

41
Thymus, Lung, Skin, Heart, Prostate, T Cells, Myeloid
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Publications for Thymus Gland Disease

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Variations for Thymus Gland Disease

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Expression for Thymus Gland Disease

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Search GEO for disease gene expression data for Thymus Gland Disease.
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Pathways for Thymus Gland Disease

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Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 37
12.64 AKT1 IL2 KIT MTOR PIK3R2
2
Downstream signaling events of B Cell Receptor (BCR) 66
Show member pathways
 12.36 AKT1 KIT MTOR PIK3R2 PSMB11
3
Apoptosis Pathway 72
Show member pathways
 12.27 AKT1 IL2 MTOR PIK3R2
4
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.26 AKT1 IL2 MTOR PIK3R2
5
Phospholipase D signaling pathway 37
Show member pathways
 12.18 AKT1 KIT MTOR PIK3R2
6
G-protein signaling RAC1 in cellular process 22
Show member pathways
 12.15 IL2 KIT MTOR MUSK PIK3R2
7
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.86 CD5 IL2 KIT
8
Thyroid hormone signaling pathway 37
11.86 AKT1 MTOR PIK3R2
9
Glioblastoma Multiforme 64
11.83 AKT1 MTOR PIK3R2
10
Insulin resistance 37
Show member pathways
 11.81 AKT1 MTOR PIK3R2
11
HIF-1 signaling pathway 37
11.76 AKT1 MTOR PIK3R2
12
TGF-beta Signaling Pathways 65
11.73 AKT1 MTOR PIK3R2
13
Type II diabetes mellitus 37 1
Show member pathways
 11.73 AKT1 MTOR PIK3R2
14
Immune response Function of MEF2 in T lymphocytes 22
Show member pathways
 11.71 AKT1 IL2 MTOR PIK3R2
15
Fc gamma R-mediated phagocytosis 37
11.69 AKT1 AMPH PIK3R2
16
LT-BetaR Pathway 64
Show member pathways
 11.61 AKT1 IL2 PIK3R2
17
VEGF Pathway (Tocris) 61
Show member pathways
 11.57 AKT1 KIT PIK3R2
18
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.44 AKT1 MTOR PIK3R2
19
IL2 signaling events mediated by PI3K 1
Show member pathways
 11.41 AKT1 IL2 MTOR
20
Jak-Stat Signaling Pathway (sino) 67
11.4 AKT1 IL2 MTOR PIK3R2
21
Regulation of Telomerase 1
11.36 AKT1 IL2 MTOR
22
Telomere Extension by Telomerase 64
Show member pathways
 11.03 AKT1 IL2 PIK3R2
23
4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression 1
10.87 AKT1 MTOR
24
Central carbon metabolism in cancer 37
10.74 AKT1 KIT MTOR PIK3R2
25
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities 1
10.61 AKT1 MTOR PIK3R2
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GO Terms for Thymus Gland Disease

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Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.91 AKT1 KIT MTOR MUSK TTN
2 positive regulation of gene expression GO:0010628 9.55 AKT1 KIT MTOR MUSK TTN
3 positive regulation of lipid biosynthetic process GO:0046889 9.49 AKT1 MTOR
4 regulation of myelination GO:0031641 9.48 AKT1 MTOR
5 TOR signaling GO:0031929 9.46 AKT1 MTOR
6 negative regulation of macroautophagy GO:0016242 9.43 AKT1 MTOR
7 anoikis GO:0043276 9.4 AKT1 MTOR
8 negative regulation of cell size GO:0045792 9.37 AKT1 MTOR
9 skeletal muscle acetylcholine-gated channel clustering GO:0071340 9.32 LRP4 MUSK
10 regulation of glycogen biosynthetic process GO:0005979 9.26 AKT1 MTOR
11 positive regulation of protein phosphorylation GO:0001934 9.26 AKT1 IL2 MTOR MUSK
12 protein autophosphorylation GO:0046777 8.92 AKT1 KIT MTOR MUSK

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.53 AIRE AKT1 AMPH CD5 CNTNAP2 DPYSL5
2 protein kinase activity GO:0004672 9.35 AKT1 KIT MTOR MUSK TTN
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Sources for Thymus Gland Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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