Thymus Gland Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: THY026 MIFTS: 32	Thymus Gland Disease Categories: Endocrine diseases, Immune diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease ¹² ¹⁵

Disease of Thymus Gland ¹²

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Diseases of thymus

Disease of thymus, unspecified

External Ids:

Disease Ontology ¹² DOID:533

ICD9CM ³⁴ 254 254.9

NCIt ⁴⁹ C26962

SNOMED-CT ⁶⁷ 20673009

ICD10 ³² E32 E32.9

UMLS ⁷¹ C0154199

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Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to cork-handlers' disease and syphilitic meningitis. An important gene associated with Thymus Gland Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Akt Signaling. Affiliated tissues include thymus, skin and t cells, and related phenotypes are behavior/neurological and growth/size/body region

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Related Diseases for Thymus Gland Disease

Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 378)

#	Related Disease	Score	Top Affiliating Genes
1	cork-handlers' disease	10.7	CD8A CD4
2	syphilitic meningitis	10.7	CD8A CD4
3	thymic epithelial tumor	10.7	KIT CD5
4	spongiotic dermatitis	10.7	CD8A CD4 CCR6
5	mikulicz disease	10.7	ICOSLG CD4 CCR6
6	ventilation pneumonitis	10.7	CD8A CD4
7	pneumonic tularemia	10.7	CD8A CD4 CCR6
8	blastomycosis	10.7	CD8A CD4 CCR6
9	parapsoriasis	10.7	CD8A CD5 CD4
10	spindle epithelial tumor with thymus-like differentiation tumor	10.7	KIT CD5
11	diffuse infiltrative lymphocytosis syndrome	10.7	CD8A CD4
12	central nervous system vasculitis	10.7	CD8A CD4 CCR6
13	autoimmune lymphoproliferative syndrome, type iia	10.7	CD8A CD4
14	nail disorder, nonsyndromic congenital, 1	10.7	CCR6 AIRE
15	chronic conjunctivitis	10.7	ICOSLG CD4 CCR6
16	acute proliferative glomerulonephritis	10.7	ICOSLG CD4 CCR6
17	cardiomyopathy, familial hypertrophic, 9	10.7	TTN CD8A CD4
18	nut allergy	10.7	ICOSLG CD4 CCR6
19	autoimmune peripheral neuropathy	10.7	ICOSLG CD4 AIRE
20	pneumocystosis	10.7	CD8A CD4 CCR6
21	igg4-related disease	10.7	ICOSLG CD4 CCR6
22	autoimmune disease of skin and connective tissue	10.7	ICOSLG CD4 CCR6
23	immunodeficiency with hyper-igm, type 3	10.7	ICOSLG CD8A CD4
24	blepharitis	10.7	CD8A CD4 CCR6
25	acute myocarditis	10.7	H2AC18 CD8A CD4
26	histoplasmosis	10.7	CD8A CD4 CCR6
27	streptococcus pneumonia	10.7	H2AC18 CD8A CD4
28	immune-complex glomerulonephritis	10.6	ICOSLG H2AC18 CD4
29	genital herpes	10.6	CD8A CD4 CCR6
30	scleral disease	10.6	IL2 CD4 CCR6
31	cryptococcosis	10.6	CD8A CD4 CCR6
32	panuveitis	10.6	CD8A CD4 CCR6
33	plasma protein metabolism disease	10.6	CD5 CD4 CCR6
34	autoimmune neuropathy	10.6	ICOSLG CNTNAP2 CD4
35	alopecia universalis congenita	10.6	CD8A CD4 AIRE
36	superficial basal cell carcinoma	10.6	IL2 CD8A CD4
37	oral tuberculosis	10.6	IL2 CD8A CD4
38	thymus clear cell carcinoma	10.6	TTN KIT CD5
39	farmer's lung	10.6	IL2 CD8A CD4
40	tuberculoid leprosy	10.6	IL2 CD4 CCR6
41	bullous skin disease	10.6	ICOSLG CD4 CCR6
42	parotid disease	10.6	TP53 CD8A CD4
43	chromosome 14q11-q22 deletion syndrome	10.6	CD8A CD4
44	middle ear disease	10.6	CD8A CD4 CCR6
45	pneumonic plague	10.6	IL2 CD8A CD4
46	anal squamous cell carcinoma	10.6	TP53 H2AC18 AKT1
47	diabetes mellitus, insulin-dependent, 23	10.6	CD8A CD4
48	chorioretinitis	10.6	IL2 CD8A CD4
49	immunodeficiency 18	10.6	PTPRC CD8A CD4
50	autosomal dominant epilepsy with auditory features	10.6	LGI1 CNTNAP2

Graphical network of the top 20 diseases related to Thymus Gland Disease:

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Symptoms & Phenotypes for Thymus Gland Disease

MGI Mouse Phenotypes related to Thymus Gland Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.26	AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2	growth/size/body region	MP:0005378	10.21	AIRE AKT1 CD4 CNTNAP2 IL2 KIT
3	endocrine/exocrine gland	MP:0005379	10.16	AIRE AKT1 AMPH CD4 CD8A IL2
4	immune system	MP:0005387	10.15	AIRE AKT1 CCR6 CD4 CD5 CD8A
5	hematopoietic system	MP:0005397	10.14	AIRE AKT1 CCR6 CD4 CD5 CD8A
6	nervous system	MP:0003631	10.13	AIRE AKT1 AMPH CCR6 CD4 CD5
7	integument	MP:0010771	10.02	AKT1 CD4 CD5 CD8A CNTNAP2 KIT
8	no phenotypic analysis	MP:0003012	9.76	AIRE CD4 CD5 IL2 KIT MTOR
9	normal	MP:0002873	9.7	AIRE AKT1 CCR6 CD4 CD5 CD8A
10	respiratory system	MP:0005388	9.23	AIRE AKT1 IL2 KIT MTOR MUSK

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Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

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Genetic Tests for Thymus Gland Disease

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Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

⁴⁰

Thymus, Skin, T Cells, B Cells, Bone, Lung, Breast

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Publications for Thymus Gland Disease

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Genes for Thymus Gland Disease

Genes related to Thymus Gland Disease (0 elite genes):

(show all 41)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.32	DISEASES inferred ¹⁵ ¹⁵
2	H2AC18	H2A Clustered Histone 18	Protein Coding	8.47	DISEASES inferred ¹⁵ ¹⁵
3	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	8.11	DISEASES inferred ¹⁵
4	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	7.66	DISEASES inferred ¹⁵
5	CD8A	CD8a Molecule	Protein Coding	7.65	DISEASES inferred ¹⁵
6	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	7.51	DISEASES inferred ¹⁵ ¹⁵
7	CD5	CD5 Molecule	Protein Coding	7.5	DISEASES inferred ¹⁵
8	CD4	CD4 Molecule	Protein Coding	7.46	DISEASES inferred ¹⁵
9	TTN	Titin	Protein Coding	7.35	DISEASES inferred ¹⁵
10	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	7.27	DISEASES inferred ¹⁵
11	AIRE	Autoimmune Regulator	Protein Coding	7.25	DISEASES inferred ¹⁵
12	MIR125A	MicroRNA 125a	RNA Gene	7.07	DISEASES inferred ¹⁵ ¹⁵
13	CNTNAP2	Contactin Associated Protein 2	Protein Coding	7.04	DISEASES inferred ¹⁵
14	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	6.99	DISEASES inferred ¹⁵
15	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	6.96	DISEASES inferred ¹⁵
16	IL2	Interleukin 2	Protein Coding	6.93	DISEASES inferred ¹⁵
17	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	6.71	DISEASES inferred ¹⁵
18	TP53	Tumor Protein P53	Protein Coding	6.6	DISEASES inferred ¹⁵
19	AMPH	Amphiphysin	Protein Coding	6.58	DISEASES inferred ¹⁵
20	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	6.56	DISEASES inferred ¹⁵
21	PTEN	Phosphatase And Tensin Homolog	Protein Coding	6.46	DISEASES inferred ¹⁵
22	H2BC21	H2B Clustered Histone 21	Protein Coding	6.44	DISEASES inferred ¹⁵
23	KCNA4	Potassium Voltage-Gated Channel Subfamily A Member 4	Protein Coding	6.42	DISEASES inferred ¹⁵
24	EGFR	Epidermal Growth Factor Receptor	Protein Coding	6.38	DISEASES inferred ¹⁵
25	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	6.37	DISEASES inferred ¹⁵
26	PNMA2	PNMA Family Member 2	Protein Coding	6.37	DISEASES inferred ¹⁵
27	LRP4	LDL Receptor Related Protein 4	Protein Coding	6.3	DISEASES inferred ¹⁵
28	DNTT	DNA Nucleotidylexotransferase	Protein Coding	6.28	DISEASES inferred ¹⁵
29	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	6.27	DISEASES inferred ¹⁵
30	CD1E	CD1e Molecule	Protein Coding	6.24	DISEASES inferred ¹⁵
31	CD1B	CD1b Molecule	Protein Coding	6.24	DISEASES inferred ¹⁵
32	CD1A	CD1a Molecule	Protein Coding	6.24	DISEASES inferred ¹⁵
33	CD40LG	CD40 Ligand	Protein Coding	6.24	DISEASES inferred ¹⁵
34	KRT5	Keratin 5	Protein Coding	6.22	DISEASES inferred ¹⁵
35	CD274	CD274 Molecule	Protein Coding	6.18	DISEASES inferred ¹⁵
36	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6.18	DISEASES inferred ¹⁵
37	AGRN	Agrin	Protein Coding	6.17	DISEASES inferred ¹⁵
38	CD1C	CD1c Molecule	Protein Coding	6.15	DISEASES inferred ¹⁵
39	PSMB11	Proteasome Subunit Beta 11	Protein Coding	6.11	DISEASES inferred ¹⁵
40	CD1D	CD1d Molecule	Protein Coding	6.11	DISEASES inferred ¹⁵
41	DDX41	DEAD-Box Helicase 41	Protein Coding	6.08	DISEASES inferred ¹⁵

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Variations for Thymus Gland Disease

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Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

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Pathways for Thymus Gland Disease

Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 26)

#	Super pathways	Score	Top Affiliating Genes
1	Class I MHC mediated antigen processing and presentation ⁶⁵ Show member pathways Adaptive Immune System ⁶⁵ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁵	13.36	TP53 PTPRC MTOR KIT ICOSLG CD8A
2	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.31	TP53 MUSK MTOR KIT IL2 CD4
3	Immune response NFAT in immune response ²² Show member pathways Immune response CD28 signaling ²² Immune response ICOS pathway in T-helper cell ²² Immune response T cell receptor signaling pathway ²²	12.54	PTPRC IL2 ICOSLG CD4 AKT1
4	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.42	PTPRC MTOR IL2 CD8A CD4 AKT1
5	ICos-ICosL Pathway in T-Helper Cell ⁶³ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶³ CD28 Signaling in T-Helper Cell ⁶³	12.26	PTPRC IL2 ICOSLG CD4 AKT1
6	Human T-cell leukemia virus 1 infection ³⁶	12.25	TP53 IL2 CD4 AKT1
7	B Cell Receptor Signaling Pathway (sino) ⁶⁶ Show member pathways B Cell Receptor Signaling Pathway ⁶⁶	12.24	PTPRC MTOR CD4 AKT1
8	CD28 co-stimulation ⁶⁵ Show member pathways Activation of AKT2 ⁶⁵ CD28 dependent PI3K/Akt signaling ⁶⁵ CD28 dependent Vav1 pathway ⁶⁵ Costimulation by the CD28 family ⁶⁵ VEGFR2 mediated vascular permeability ⁶⁵	12.11	MTOR ICOSLG CD4 AKT1
9	Cell adhesion molecules (CAMs) ³⁶	11.93	PTPRC ICOSLG CNTNAP2 CD8A CD4
10	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.88	MTOR IL2 CD8A CD4
11	TCR signaling in naive CD4+ T cells ¹ Show member pathways TCR signaling in naive CD8+ T cells ¹	11.84	PTPRC CD8A CD4 AKT1
12	Jak-Stat Signaling Pathway (sino) ⁶⁶	11.79	PTPRC MTOR IL2 AKT1
13	Hematopoietic cell lineage ³⁶	11.79	KIT CD8A CD5 CD4
14	Glucocorticoid receptor regulatory network ¹	11.72	TP53 IL2 AKT1
15	Regulation of TP53 Expression and Degradation ⁶⁵ Show member pathways Regulation of TP53 Degradation ⁶⁵ Regulation of TP53 Expression ⁶⁵	11.66	TP53 MTOR AKT1
16	CTLA4 Signaling ⁶³	11.64	CD8A CD4 AKT1
17	CXCR4-mediated signaling events ¹	11.64	PTPRC MTOR CD4 AKT1
18	IL2 signaling events mediated by PI3K ¹ Show member pathways IL2 signaling events mediated by STAT5 ¹	11.6	MTOR IL2 AKT1
19	Regulation of Telomerase ¹	11.59	MTOR IL2 AKT1
20	Central carbon metabolism in cancer ³⁶	11.57	TP53 MTOR KIT AKT1
21	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.5	PTPRC KIT IL2 CD8A CD5 CD4
22	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.42	PTPRC KIT IL2 CD8A CD4
23	B Cell Development Pathways ⁶⁴	11.35	PTPRC KIT CD5 CD4
24	T-Cell Receptor and Co-stimulatory Signaling ¹	11.2	IL2 CD8A AKT1
25	Primary immunodeficiency ³⁶	11.14	PTPRC CD8A CD4 AIRE
26	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11	PTPRC KIT IL2 CD8A CD4 CCR6

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GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.17	PTPRC KIT ICOSLG CD8A CD5 CD4

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10	IL2 CD8A CD4 CCR6 AIRE
2	cytokine-mediated signaling pathway	GO:0019221	9.85	TP53 KIT IL2 CD4 AKT1
3	protein autophosphorylation	GO:0046777	9.78	MUSK MTOR KIT AKT1
4	positive regulation of cell growth	GO:0030307	9.76	LGI1 IL2 AKT1
5	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.73	MUSK KIT CD8A CD4
6	hematopoietic progenitor cell differentiation	GO:0002244	9.71	TP53 PTPRC KIT
7	positive regulation of MAPK cascade	GO:0043410	9.71	PTPRC MUSK KIT CD4
8	positive regulation of T cell proliferation	GO:0042102	9.69	PTPRC IL2 CD4
9	T cell costimulation	GO:0031295	9.67	ICOSLG CD5 AKT1
10	positive regulation of protein phosphorylation	GO:0001934	9.65	MUSK MTOR IL2 CD4 AKT1
11	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.62	TP53 PTPRC MTOR CD4
12	negative thymic T cell selection	GO:0045060	9.6	PTPRC AIRE
13	anoikis	GO:0043276	9.59	MTOR AKT1
14	positive regulation of isotype switching to IgG isotypes	GO:0048304	9.58	PTPRC IL2
15	negative regulation of cell size	GO:0045792	9.57	MTOR AKT1
16	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO:0097011	9.56	CD4 AKT1
17	bone marrow development	GO:0048539	9.55	TP53 PTPRC
18	regulation of glycogen biosynthetic process	GO:0005979	9.52	MTOR AKT1
19	positive regulation of gene expression	GO:0010628	9.5	TTN TP53 MUSK MTOR MIR125A KIT
20	T cell activation	GO:0042110	9.46	PTPRC ICOSLG CD8A CD4
21	DN2 thymocyte differentiation	GO:1904155	9.37	PTPRC CCR6
22	T cell differentiation	GO:0030217	8.92	PTPRC KIT IL2 CD4

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:0005515	9.91	TTN TP53 PTPRC MUSK MTOR LGI1
2	identical protein binding	GO:0042802	9.8	TTN TP53 MTOR ICOSLG CD4 AKT1
3	enzyme binding	GO:0019899	9.55	TTN TP53 CNTNAP2 CD4 AKT1
4	protein kinase binding	GO:0019901	9.17	TTN TP53 PTPRC MTOR CD8A CD4

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Sources for Thymus Gland Disease

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⁷⁴ Wikipedia