MCID: THY026
MIFTS: 28

Thymus Gland Disease

Categories: Endocrine diseases, Immune diseases

Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease 12 15
Disease of Thymus Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:533
ICD9CM 34 254
NCIt 49 C26962
SNOMED-CT 67 20673009
ICD10 32 E32
UMLS 71 C0154199

Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to cork-handlers' disease and thymic epithelial tumor. An important gene associated with Thymus Gland Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Akt Signaling and T cell receptor signaling pathway. Affiliated tissues include thymus, and related phenotypes are behavior/neurological and immune system

Related Diseases for Thymus Gland Disease

Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 387)
# Related Disease Score Top Affiliating Genes
1 cork-handlers' disease 10.7 CD8A CD4
2 thymic epithelial tumor 10.7 KIT CD5
3 pneumonic tularemia 10.7 CD8A CD4 CCR6
4 tularemia 10.7 CD8A CD4 CCR6
5 parapsoriasis 10.7 CD8A CD5 CD4
6 iritis 10.7 CD8A CD4 CCR6
7 fungal meningitis 10.7 CD8A CD4 CCR6
8 central nervous system vasculitis 10.7 CD8A CD4 CCR6
9 cardiomyopathy, familial hypertrophic, 9 10.7 TTN CD8A CD4
10 acute proliferative glomerulonephritis 10.7 ICOSLG CD4 CCR6
11 legume allergy 10.7 ICOSLG CD4 CCR6
12 spindle epithelial tumor with thymus-like differentiation tumor 10.7 KIT CD5
13 fruit allergy 10.7 ICOSLG CD4 CCR6
14 viral pneumonia 10.7 CD8A CD4 CCR6
15 epithelial malignant thymoma 10.7 TTN CD5 AIRE
16 chronic conjunctivitis 10.7 ICOSLG CD4 CCR6
17 immunodeficiency with hyper-igm, type 3 10.7 ICOSLG CD8A CD4
18 pneumocystosis 10.7 CD8A CD4 CCR6
19 autoimmune peripheral neuropathy 10.7 ICOSLG CD4 AIRE
20 childhood type dermatomyositis 10.7 ICOSLG CD4 CCR6
21 good syndrome 10.7 CD8A CD4 AIRE
22 ventilation pneumonitis 10.7 CD8A CD4
23 goodpasture syndrome 10.7 H2AC18 CD4 CCR6
24 skin sarcoidosis 10.7 IL2 CD8A CD4
25 blepharitis 10.7 CD8A CD4 CCR6
26 intestinal schistosomiasis 10.7 ICOSLG CD4 CCR6
27 histoplasmosis 10.7 CD8A CD4 CCR6
28 streptococcus pneumonia 10.7 CD8A CD4 CCR6
29 igg4-related disease 10.7 ICOSLG CD4 CCR6
30 adult acute lymphocytic leukemia 10.7 CD8A CD5 CD4 CCR6
31 scleral disease 10.6 IL2 CD4 CCR6
32 superficial basal cell carcinoma 10.6 IL2 CD8A CD4
33 cryptococcal meningitis 10.6 CD8A CD4 CCR6
34 thymus clear cell carcinoma 10.6 TTN KIT CD5
35 central nervous system hematologic cancer 10.6 CD5 CD4 CCR6
36 genital herpes 10.6 CD8A CD4 CCR6
37 alopecia universalis congenita 10.6 CD8A CD4 AIRE
38 oral tuberculosis 10.6 IL2 CD8A CD4
39 autoimmune vasculitis 10.6 IL2 CD4 CCR6
40 immune-complex glomerulonephritis 10.6 ICOSLG H2AC18 CD4
41 farmer's lung 10.6 IL2 CD8A CD4
42 lymphoepithelioma-like thymic carcinoma 10.6 KIT CD5
43 cryptococcosis 10.6 CD8A CD4 CCR6
44 tuberculoid leprosy 10.6 IL2 CD4 CCR6
45 chorioretinitis 10.6 IL2 CD8A CD4
46 middle ear disease 10.6 CD8A CD4 CCR6
47 cll/sll 10.6 TP53 CD5 CCR6
48 borst-jadassohn intraepidermal carcinoma 10.6 TP53 CD8A CD4
49 diffuse infiltrative lymphocytosis syndrome 10.6 CD8A CD4
50 dysentery 10.6 H2AC18 CD4 CCR6

Graphical network of the top 20 diseases related to Thymus Gland Disease:



Diseases related to Thymus Gland Disease

Symptoms & Phenotypes for Thymus Gland Disease

MGI Mouse Phenotypes related to Thymus Gland Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.15 AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2 immune system MP:0005387 10.06 AIRE AKT1 CCR6 CD4 CD5 CD8A
3 nervous system MP:0003631 10 AIRE AKT1 AMPH CCR6 CD4 CD5
4 integument MP:0010771 9.91 AKT1 CD4 CD5 CD8A CNTNAP2 KIT
5 no phenotypic analysis MP:0003012 9.5 AIRE CD4 CD5 IL2 KIT MTOR
6 normal MP:0002873 9.32 AIRE AKT1 CCR6 CD4 CD5 CD8A

Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

Genetic Tests for Thymus Gland Disease

Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

40
Thymus

Publications for Thymus Gland Disease

Variations for Thymus Gland Disease

Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

Pathways for Thymus Gland Disease

Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.23 TP53 MUSK MTOR KIT IL2 CD4
2
Show member pathways
12.43 MTOR IL2 CD8A CD4 AKT1
3
Show member pathways
12.27 IL2 ICOSLG CD4 AKT1
4 12.19 TP53 IL2 CD4 AKT1
5
Show member pathways
12.05 MTOR ICOSLG CD4 AKT1
6
Show member pathways
11.97 MTOR IL2 AKT1
7 11.93 ICOSLG CNTNAP2 CD8A CD4
8
Show member pathways
11.72 MTOR IL2 CD8A CD4
9 11.71 TP53 MTOR AKT1
10 11.69 TP53 IL2 AKT1
11 11.64 MTOR CD4 AKT1
12
Show member pathways
11.62 TP53 MTOR AKT1
13 11.62 KIT CD8A CD5 CD4
14 11.59 CD8A CD4 AKT1
15
Show member pathways
11.54 MTOR IL2 AKT1
16 11.52 MTOR IL2 AKT1
17 11.43 KIT IL2 CD8A CD4
18 11.42 KIT IL2 CD8A CD5 CD4
19 11.3 TP53 MTOR KIT AKT1
20 11.19 CD8A CD4 AIRE
21 11.07 IL2 CD8A AKT1
22 10.92 KIT IL2 CD8A CD4 CCR6

GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.1 KIT ICOSLG CD8A CD5 CD4 CCR6

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.91 IL2 CD8A CD4 CCR6 AIRE
2 protein autophosphorylation GO:0046777 9.73 MUSK MTOR KIT AKT1
3 positive regulation of cell growth GO:0030307 9.71 LGI1 IL2 AKT1
4 cytokine-mediated signaling pathway GO:0019221 9.65 TP53 KIT IL2 CD4 AKT1
5 T cell costimulation GO:0031295 9.63 ICOSLG CD5 AKT1
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.62 MUSK KIT CD8A CD4
7 T cell activation GO:0042110 9.58 ICOSLG CD8A CD4
8 T cell differentiation GO:0030217 9.54 KIT IL2 CD4
9 anoikis GO:0043276 9.52 MTOR AKT1
10 negative regulation of cell size GO:0045792 9.49 MTOR AKT1
11 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.48 CD4 AKT1
12 positive regulation of kinase activity GO:0033674 9.46 MUSK KIT IL2 CD4
13 positive regulation of protein phosphorylation GO:0001934 9.35 MUSK MTOR IL2 CD4 AKT1
14 positive regulation of gene expression GO:0010628 9.17 TTN TP53 MUSK MTOR MIR125A KIT

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.35 TTN TP53 MTOR CD4 AKT1
2 enzyme binding GO:0019899 9.02 TTN TP53 CNTNAP2 CD4 AKT1

Sources for Thymus Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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