Thymus Gland Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: THY026 MIFTS: 28	Thymus Gland Disease Categories: Endocrine diseases, Immune diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease ¹² ¹⁵

Disease of Thymus Gland ¹²

Classifications:

MalaCards categories:
Anatomical: Immune diseases Endocrine diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Diseases of thymus

External Ids:

Disease Ontology ¹² DOID:533

ICD9CM ³⁴ 254

NCIt ⁴⁹ C26962

SNOMED-CT ⁶⁷ 20673009

ICD10 ³² E32

UMLS ⁷¹ C0154199

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Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to cork-handlers' disease and thymic epithelial tumor. An important gene associated with Thymus Gland Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Akt Signaling and T cell receptor signaling pathway. Affiliated tissues include thymus, and related phenotypes are behavior/neurological and immune system

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Related Diseases for Thymus Gland Disease

Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 387)

#	Related Disease	Score	Top Affiliating Genes
1	cork-handlers' disease	10.7	CD8A CD4
2	thymic epithelial tumor	10.7	KIT CD5
3	pneumonic tularemia	10.7	CD8A CD4 CCR6
4	tularemia	10.7	CD8A CD4 CCR6
5	parapsoriasis	10.7	CD8A CD5 CD4
6	iritis	10.7	CD8A CD4 CCR6
7	fungal meningitis	10.7	CD8A CD4 CCR6
8	central nervous system vasculitis	10.7	CD8A CD4 CCR6
9	cardiomyopathy, familial hypertrophic, 9	10.7	TTN CD8A CD4
10	acute proliferative glomerulonephritis	10.7	ICOSLG CD4 CCR6
11	legume allergy	10.7	ICOSLG CD4 CCR6
12	spindle epithelial tumor with thymus-like differentiation tumor	10.7	KIT CD5
13	fruit allergy	10.7	ICOSLG CD4 CCR6
14	viral pneumonia	10.7	CD8A CD4 CCR6
15	epithelial malignant thymoma	10.7	TTN CD5 AIRE
16	chronic conjunctivitis	10.7	ICOSLG CD4 CCR6
17	immunodeficiency with hyper-igm, type 3	10.7	ICOSLG CD8A CD4
18	pneumocystosis	10.7	CD8A CD4 CCR6
19	autoimmune peripheral neuropathy	10.7	ICOSLG CD4 AIRE
20	childhood type dermatomyositis	10.7	ICOSLG CD4 CCR6
21	good syndrome	10.7	CD8A CD4 AIRE
22	ventilation pneumonitis	10.7	CD8A CD4
23	goodpasture syndrome	10.7	H2AC18 CD4 CCR6
24	skin sarcoidosis	10.7	IL2 CD8A CD4
25	blepharitis	10.7	CD8A CD4 CCR6
26	intestinal schistosomiasis	10.7	ICOSLG CD4 CCR6
27	histoplasmosis	10.7	CD8A CD4 CCR6
28	streptococcus pneumonia	10.7	CD8A CD4 CCR6
29	igg4-related disease	10.7	ICOSLG CD4 CCR6
30	adult acute lymphocytic leukemia	10.7	CD8A CD5 CD4 CCR6
31	scleral disease	10.6	IL2 CD4 CCR6
32	superficial basal cell carcinoma	10.6	IL2 CD8A CD4
33	cryptococcal meningitis	10.6	CD8A CD4 CCR6
34	thymus clear cell carcinoma	10.6	TTN KIT CD5
35	central nervous system hematologic cancer	10.6	CD5 CD4 CCR6
36	genital herpes	10.6	CD8A CD4 CCR6
37	alopecia universalis congenita	10.6	CD8A CD4 AIRE
38	oral tuberculosis	10.6	IL2 CD8A CD4
39	autoimmune vasculitis	10.6	IL2 CD4 CCR6
40	immune-complex glomerulonephritis	10.6	ICOSLG H2AC18 CD4
41	farmer's lung	10.6	IL2 CD8A CD4
42	lymphoepithelioma-like thymic carcinoma	10.6	KIT CD5
43	cryptococcosis	10.6	CD8A CD4 CCR6
44	tuberculoid leprosy	10.6	IL2 CD4 CCR6
45	chorioretinitis	10.6	IL2 CD8A CD4
46	middle ear disease	10.6	CD8A CD4 CCR6
47	cll/sll	10.6	TP53 CD5 CCR6
48	borst-jadassohn intraepidermal carcinoma	10.6	TP53 CD8A CD4
49	diffuse infiltrative lymphocytosis syndrome	10.6	CD8A CD4
50	dysentery	10.6	H2AC18 CD4 CCR6

Graphical network of the top 20 diseases related to Thymus Gland Disease:

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Symptoms & Phenotypes for Thymus Gland Disease

MGI Mouse Phenotypes related to Thymus Gland Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.15	AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2	immune system	MP:0005387	10.06	AIRE AKT1 CCR6 CD4 CD5 CD8A
3	nervous system	MP:0003631	10	AIRE AKT1 AMPH CCR6 CD4 CD5
4	integument	MP:0010771	9.91	AKT1 CD4 CD5 CD8A CNTNAP2 KIT
5	no phenotypic analysis	MP:0003012	9.5	AIRE CD4 CD5 IL2 KIT MTOR
6	normal	MP:0002873	9.32	AIRE AKT1 CCR6 CD4 CD5 CD8A

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Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

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Genetic Tests for Thymus Gland Disease

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Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

⁴⁰

Thymus

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Publications for Thymus Gland Disease

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Genes for Thymus Gland Disease

Genes related to Thymus Gland Disease (0 elite genes):

(show all 43)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	9.22	DISEASES inferred ¹⁵ ¹⁵
2	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	8.27	DISEASES inferred ¹⁵
3	H2AC18	H2A Clustered Histone 18	Protein Coding	8	DISEASES inferred ¹⁵ ¹⁵
4	CD8A	CD8a Molecule	Protein Coding	7.66	DISEASES inferred ¹⁵
5	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	7.62	DISEASES inferred ¹⁵
6	CD5	CD5 Molecule	Protein Coding	7.52	DISEASES inferred ¹⁵
7	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	7.51	DISEASES inferred ¹⁵ ¹⁵
8	CD4	CD4 Molecule	Protein Coding	7.5	DISEASES inferred ¹⁵
9	TTN	Titin	Protein Coding	7.4	DISEASES inferred ¹⁵
10	MIR125A	MicroRNA 125a	RNA Gene	7.37	DISEASES inferred ¹⁵ ¹⁵
11	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	7.36	DISEASES inferred ¹⁵
12	AIRE	Autoimmune Regulator	Protein Coding	7.31	DISEASES inferred ¹⁵
13	CNTNAP2	Contactin Associated Protein 2	Protein Coding	7.11	DISEASES inferred ¹⁵
14	LGI1	Leucine Rich Glioma Inactivated 1	Protein Coding	7.1	DISEASES inferred ¹⁵
15	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	7.05	DISEASES inferred ¹⁵
16	IL2	Interleukin 2	Protein Coding	6.92	DISEASES inferred ¹⁵
17	TP53	Tumor Protein P53	Protein Coding	6.68	DISEASES inferred ¹⁵
18	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	6.67	DISEASES inferred ¹⁵
19	AMPH	Amphiphysin	Protein Coding	6.65	DISEASES inferred ¹⁵
20	MIR423	MicroRNA 423	RNA Gene	6.59	DISEASES inferred ¹⁵ ¹⁵
21	PTPRC	Protein Tyrosine Phosphatase Receptor Type C	Protein Coding	6.58	DISEASES inferred ¹⁵
22	KCNA4	Potassium Voltage-Gated Channel Subfamily A Member 4	Protein Coding	6.54	DISEASES inferred ¹⁵
23	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	6.45	DISEASES inferred ¹⁵
24	LRP4	LDL Receptor Related Protein 4	Protein Coding	6.42	DISEASES inferred ¹⁵
25	PNMA2	PNMA Family Member 2	Protein Coding	6.41	DISEASES inferred ¹⁵
26	PTEN	Phosphatase And Tensin Homolog	Protein Coding	6.4	DISEASES inferred ¹⁵
27	EGFR	Epidermal Growth Factor Receptor	Protein Coding	6.38	DISEASES inferred ¹⁵
28	H2BC21	H2B Clustered Histone 21	Protein Coding	6.37	DISEASES inferred ¹⁵
29	CD274	CD274 Molecule	Protein Coding	6.36	DISEASES inferred ¹⁵
30	CD1E	CD1e Molecule	Protein Coding	6.31	DISEASES inferred ¹⁵
31	CD1B	CD1b Molecule	Protein Coding	6.3	DISEASES inferred ¹⁵
32	CD1A	CD1a Molecule	Protein Coding	6.3	DISEASES inferred ¹⁵
33	KRT5	Keratin 5	Protein Coding	6.29	DISEASES inferred ¹⁵
34	DNTT	DNA Nucleotidylexotransferase	Protein Coding	6.28	DISEASES inferred ¹⁵
35	CD40LG	CD40 Ligand	Protein Coding	6.28	DISEASES inferred ¹⁵
36	PSMB11	Proteasome Subunit Beta 11	Protein Coding	6.25	DISEASES inferred ¹⁵
37	CD1C	CD1c Molecule	Protein Coding	6.21	DISEASES inferred ¹⁵
38	LCK	LCK Proto-Oncogene, Src Family Tyrosine Kinase	Protein Coding	6.2	DISEASES inferred ¹⁵
39	AGRN	Agrin	Protein Coding	6.2	DISEASES inferred ¹⁵
40	DDX41	DEAD-Box Helicase 41	Protein Coding	6.2	DISEASES inferred ¹⁵
41	AKT2	AKT Serine/Threonine Kinase 2	Protein Coding	6.18	DISEASES inferred ¹⁵
42	CD1D	CD1d Molecule	Protein Coding	6.14	DISEASES inferred ¹⁵
43	SYP	Synaptophysin	Protein Coding	6.1	DISEASES inferred ¹⁵

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Variations for Thymus Gland Disease

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Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

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Pathways for Thymus Gland Disease

Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 22)

#	Super pathways	Score	Top Affiliating Genes
1	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.23	TP53 MUSK MTOR KIT IL2 CD4
2	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.43	MTOR IL2 CD8A CD4 AKT1
3	ICos-ICosL Pathway in T-Helper Cell ⁶³ Show member pathways Calcium Mediated T-Cell Apoptosis ⁶³ CD28 Signaling in T-Helper Cell ⁶³	12.27	IL2 ICOSLG CD4 AKT1
4	Human T-cell leukemia virus 1 infection ³⁶	12.19	TP53 IL2 CD4 AKT1
5	CD28 co-stimulation ⁶⁵ Show member pathways Activation of AKT2 ⁶⁵ CD28 dependent PI3K/Akt signaling ⁶⁵ CD28 dependent Vav1 pathway ⁶⁵ Costimulation by the CD28 family ⁶⁵ VEGFR2 mediated vascular permeability ⁶⁵	12.05	MTOR ICOSLG CD4 AKT1
6	Jak Stat Signaling Pathway ⁶⁶ Show member pathways Commom Cytokine Receptor G Chain Siganaling Pathway ⁶⁶	11.97	MTOR IL2 AKT1
7	Cell adhesion molecules (CAMs) ³⁶	11.93	ICOSLG CNTNAP2 CD8A CD4
8	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.72	MTOR IL2 CD8A CD4
9	TP53 Regulates Metabolic Genes ⁶⁵	11.71	TP53 MTOR AKT1
10	Glucocorticoid receptor regulatory network ¹	11.69	TP53 IL2 AKT1
11	CXCR4-mediated signaling events ¹	11.64	MTOR CD4 AKT1
12	Regulation of TP53 Expression and Degradation ⁶⁵ Show member pathways Regulation of TP53 Degradation ⁶⁵ Regulation of TP53 Expression ⁶⁵	11.62	TP53 MTOR AKT1
13	Hematopoietic cell lineage ³⁶	11.62	KIT CD8A CD5 CD4
14	CTLA4 Signaling ⁶³	11.59	CD8A CD4 AKT1
15	IL2 signaling events mediated by PI3K ¹ Show member pathways IL2 signaling events mediated by STAT5 ¹	11.54	MTOR IL2 AKT1
16	Regulation of Telomerase ¹	11.52	MTOR IL2 AKT1
17	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.43	KIT IL2 CD8A CD4
18	Hematopoietic Stem Cells and Lineage-specific Markers ⁶⁴	11.42	KIT IL2 CD8A CD5 CD4
19	Central carbon metabolism in cancer ³⁶	11.3	TP53 MTOR KIT AKT1
20	Primary immunodeficiency ³⁶	11.19	CD8A CD4 AIRE
21	T-Cell Receptor and Co-stimulatory Signaling ¹	11.07	IL2 CD8A AKT1
22	Innate Lymphoid Cells Differentiation ⁶⁴	10.92	KIT IL2 CD8A CD4 CCR6

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GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	external side of plasma membrane	GO:0009897	9.1	KIT ICOSLG CD8A CD5 CD4 CCR6

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	9.91	IL2 CD8A CD4 CCR6 AIRE
2	protein autophosphorylation	GO:0046777	9.73	MUSK MTOR KIT AKT1
3	positive regulation of cell growth	GO:0030307	9.71	LGI1 IL2 AKT1
4	cytokine-mediated signaling pathway	GO:0019221	9.65	TP53 KIT IL2 CD4 AKT1
5	T cell costimulation	GO:0031295	9.63	ICOSLG CD5 AKT1
6	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.62	MUSK KIT CD8A CD4
7	T cell activation	GO:0042110	9.58	ICOSLG CD8A CD4
8	T cell differentiation	GO:0030217	9.54	KIT IL2 CD4
9	anoikis	GO:0043276	9.52	MTOR AKT1
10	negative regulation of cell size	GO:0045792	9.49	MTOR AKT1
11	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO:0097011	9.48	CD4 AKT1
12	positive regulation of kinase activity	GO:0033674	9.46	MUSK KIT IL2 CD4
13	positive regulation of protein phosphorylation	GO:0001934	9.35	MUSK MTOR IL2 CD4 AKT1
14	positive regulation of gene expression	GO:0010628	9.17	TTN TP53 MUSK MTOR MIR125A KIT

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	9.35	TTN TP53 MTOR CD4 AKT1
2	enzyme binding	GO:0019899	9.02	TTN TP53 CNTNAP2 CD4 AKT1

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Sources for Thymus Gland Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

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¹⁷ EFO

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia