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MCID: THY026
MIFTS: 26

Thymus Gland Disease

Categories: Endocrine diseases, Immune diseases
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Genes Tissues Related diseases
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Aliases & Classifications for Thymus Gland Disease

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MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease 11 14
Disease of Thymus Gland 11

Classifications:

MalaCards categories:
Anatomical: Immune diseases Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 31


External Ids:

Disease Ontology 11 DOID:533
ICD9CM 34 254
NCIt 49 C26962
SNOMED-CT 68 20673009
ICD10 31 E32
UMLS 71 C0154199
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Summaries for Thymus Gland Disease

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MalaCards based summary: Thymus Gland Disease, also known as disease of thymus gland, is related to proliferative glomerulonephritis and hilar lung neoplasm. An important gene associated with Thymus Gland Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are T-cell activation SARS-CoV-2 and CD28 co-stimulation. Affiliated tissues include thymus, and related phenotypes are nervous system and no phenotypic analysis
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Related Diseases for Thymus Gland Disease

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Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 563)
# Related Disease Score Top Affiliating Genes
1 proliferative glomerulonephritis 10.5 ICOSLG H2AC18 CCR6
2 hilar lung neoplasm 10.5 CD8A CD4
3 mikulicz disease 10.5 ICOSLG CD4 CCR6
4 gastroduodenitis 10.5 CD8A CD4 CCR6
5 skin sarcoidosis 10.5 CD8A CD4 CCR6
6 syphilis 10.5 CD8A CD4 CCR6
7 invasive malignant thymoma 10.5 MUSK CD8A CD4
8 autoimmune cholangitis 10.5 CD8A CD4 CCR6
9 farmer's lung 10.5 CD8A CD4 CCR6
10 follicular mucinosis 10.5 CD8A CD5 CD4
11 evans' syndrome 10.5 CD8A CD4 CCR6
12 pollen allergy 10.5 ICOSLG CD4 CCR6
13 wissler-fanconi syndrome 10.5 CD8A CD4 AIRE
14 parapsoriasis 10.5 CD8A CD5 CD4
15 primary cutaneous gamma-delta t-cell lymphoma 10.5 CD8A CD5 CD4
16 serous cystadenocarcinoma 10.5 TP53 H2AC18 AKT1
17 immunodeficiency 13 10.5 ICOSLG CD8A CD4
18 scabies 10.5 CD8A CD4 CCR6
19 igg4-related disease 10.5 ICOSLG CD4 CCR6
20 iritis 10.5 CD8A CD4 CCR6
21 non-severe covid-19 10.5 CD8A CD4 CCR6
22 severe covid-19 10.5 CD8A CD4 CCR6
23 legume allergy 10.5 ICOSLG CD4 CCR6
24 mite infestation 10.5 CD8A CD4 CCR6
25 multicentric castleman disease 10.5 H2AC18 CD4 CCR6
26 fruit allergy 10.5 ICOSLG CD4 CCR6
27 castleman disease 10.5 H2AC18 CD4 CCR6
28 selective immunoglobulin deficiency disease 10.5 ICOSLG CD8A CD4
29 fungal meningitis 10.5 CD8A CD4 CCR6
30 tuberculoid leprosy 10.5 CD8A CD4 CCR6
31 mucocutaneous leishmaniasis 10.5 H2AC18 CD8A CD4
32 aggressive nk-cell leukemia 10.5 CD8A CD5 CD4
33 nonspecific interstitial pneumonia 10.5 CD8A CD4 CCR6
34 hepatosplenic t-cell lymphoma 10.5 CD8A CD5 CD4
35 hantavirus hemorrhagic fever with renal syndrome 10.5 CD8A CD4 CCR6
36 peanut allergy 10.5 ICOSLG CD4 CCR6
37 long covid 10.5 CD8A CD4 CCR6
38 chronic conjunctivitis 10.5 ICOSLG CD4 CCR6
39 cryptococcal meningitis 10.5 CD8A CD4 CCR6
40 chorioretinitis 10.5 CD8A CD4 CCR6
41 acute asthma 10.5 ICOSLG CD4 CCR6
42 genital herpes 10.5 CD8A CD4 CCR6
43 gastric lymphoma 10.5 ICOSLG CD5 CCR6
44 immunodeficiency with hyper-igm, type 3 10.5 ICOSLG CD8A CD4
45 childhood type dermatomyositis 10.5 ICOSLG CD4 CCR6
46 birdshot chorioretinopathy 10.5 CD8A CD4 CCR6
47 dysgammaglobulinemia 10.5 ICOSLG CD8A CD4
48 oral tuberculosis 10.5 CD8A CD4
49 tularemia 10.5 CD8A CD4 CCR6
50 epithelial malignant thymoma 10.5 TTN CD5 AIRE

Graphical network of the top 20 diseases related to Thymus Gland Disease:



Diseases related to Thymus Gland Disease
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Symptoms & Phenotypes for Thymus Gland Disease

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MGI Mouse Phenotypes related to Thymus Gland Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.93 AIRE AKT1 CCR6 CD4 CD8A CNTNAP2
2 no phenotypic analysis MP:0003012 9.8 AIRE CD274 CD4 CD5 KIT MIR205
3 immune system MP:0005387 9.77 AIRE AKT1 CCR6 CD274 CD4 CD5
4 integument MP:0010771 9.36 AKT1 CD274 CD4 CD5 CD8A KIT
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Drugs & Therapeutics for Thymus Gland Disease

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Search Clinical Trials, NIH Clinical Center for Thymus Gland Disease

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Genetic Tests for Thymus Gland Disease

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Anatomical Context for Thymus Gland Disease

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Organs/tissues related to Thymus Gland Disease:

MalaCards : Thymus
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Publications for Thymus Gland Disease

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Variations for Thymus Gland Disease

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Expression for Thymus Gland Disease

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Search GEO for disease gene expression data for Thymus Gland Disease.
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Pathways for Thymus Gland Disease

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Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
T-cell activation SARS-CoV-2 74
Show member pathways
 11.74 TP53 CD8A CD4 AKT1
2
CD28 co-stimulation 66
Show member pathways
 11.73 ICOSLG CD8A CD4 CD274 AKT1
3
Hematopoietic Stem Cells and Lineage-specific Markers 65
11.52 KIT CD8A CD5 CD4
4
Network map of SARS-CoV-2 signaling pathway 74
Show member pathways
 11.47 CD8A CD4 AKT1
5
Dendritic Cells Developmental Lineage Pathway 65
11.37 KIT CD8A CD4
6
Innate Lymphoid Cells Differentiation 65
10.83 KIT CD8A CD4 CCR6
7
Caloric restriction and aging 74
10.32 TP53 AKT1
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GO Terms for Thymus Gland Disease

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Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.47 KIT ICOSLG CD8A CD5 CD4 CD274

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.86 MUSK KIT CD8A CD4
2 negative regulation of gene expression GO:0010629 9.8 TP53 MIR205 MIR140 MIR125A AKT1
3 T cell costimulation GO:0031295 9.63 CD5 CD274 AKT1
4 positive regulation of gene expression GO:0010628 9.4 TTN TP53 MUSK MIR205 MIR140 MIR125A
5 negative regulation of vascular endothelial growth factor production GO:1904046 9.13 MIR205 MIR140 MIR125A
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Sources for Thymus Gland Disease

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2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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