MCID: THY026
MIFTS: 25

Thymus Gland Disease

Categories: Endocrine diseases, Immune diseases

Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease 12 15
Disease of Thymus Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:533
ICD9CM 36 254 254.9
NCIt 51 C26962
SNOMED-CT 69 20673009
ICD10 34 E32 E32.9
UMLS 74 C0154199

Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to thymic epithelial tumor and dendritic cell thymoma. An important gene associated with Thymus Gland Disease is TTN (Titin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. Affiliated tissues include thymus, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Thymus Gland Disease

Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 thymic epithelial tumor 10.4 CD5 KIT
2 dendritic cell thymoma 10.4 CD5 TTN
3 maxillary sinus adenoid cystic carcinoma 10.3 IL2 KIT
4 splenic tuberculosis 10.3 IL2 SMUG1
5 pharynx squamous cell carcinoma 10.3 AKT1 SMUG1
6 prostate lymphoma 10.3 CD5 SMUG1
7 breast lymphoma 10.3 CD5 SMUG1
8 ectopic thymus 10.3 CD5 OMG
9 mixed type thymoma 10.3 CD5 KIT
10 ocular melanoma 10.2 IL2 KIT
11 mediastinal cancer 10.2 CD5 KIT SMUG1
12 lymphoepithelioma-like thymic carcinoma 10.2 CD5 KIT
13 pharynx cancer 10.2 AKT1 KIT SMUG1
14 connective tissue cancer 10.2 AKT1 KIT SMUG1
15 intestinal disease 10.2 AKT1 IL2 SMUG1
16 myasthenia gravis 10.2 AIRE IL2 MUSK TTN
17 granulomatous myositis 10.2 SMUG1 TTN
18 lymphatic system disease 10.1 CD5 IL2 SMUG1 TTN
19 respiratory system disease 10.1 AKT1 IL2 SMUG1
20 gastrointestinal system cancer 10.1 AKT1 KIT SMUG1
21 muscular disease 10.1 AKT1 KIT SMUG1 TTN
22 gastrointestinal system disease 10.1 AKT1 IL2 KIT SMUG1
23 postsynaptic congenital myasthenic syndromes 10.1 LRP4 MUSK
24 myeloma, multiple 10.1 AKT1 IL2 KIT SMUG1
25 neuromuscular junction disease 10.1 LRP4 MUSK OMG TTN
26 leukocyte disease 10.0 AKT1 CD5 IL2 KIT SMUG1
27 breast angiosarcoma 10.0 KIT SMUG1
28 mycobacterium malmoense 9.9 CD1B CD1E
29 thymus cancer 9.0 AMPH CD5 CNTNAP2 DPYSL5 KIT PSMB11
30 thymoma 9.0 AIRE AKT1 AMPH CD5 DPYSL5 IL2

Graphical network of the top 20 diseases related to Thymus Gland Disease:



Diseases related to Thymus Gland Disease

Symptoms & Phenotypes for Thymus Gland Disease

MGI Mouse Phenotypes related to Thymus Gland Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2 nervous system MP:0003631 9.7 AIRE AKT1 AMPH CD5 CNTNAP2 DPYSL5
3 respiratory system MP:0005388 9.17 AIRE AKT1 IL2 KIT LRP4 MUSK

Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

Genetic Tests for Thymus Gland Disease

Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

42
Thymus

Publications for Thymus Gland Disease

Variations for Thymus Gland Disease

Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

Pathways for Thymus Gland Disease

Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.2 CD5 IL2 KIT
2 10.91 CD1B CD1E CD5 KIT

GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 CD1B CD1E CNTNAP2 KIT LRP4

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein phosphorylation GO:0006468 9.77 AKT1 KIT MUSK STK16 TTN
2 peptidyl-tyrosine phosphorylation GO:0018108 9.46 KIT MUSK STK16 TTN
3 negative regulation of axonogenesis GO:0050771 9.4 LRP4 OMG
4 skeletal muscle acetylcholine-gated channel clustering GO:0071340 9.32 LRP4 MUSK
5 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.26 CD1B CD1E
6 protein autophosphorylation GO:0046777 9.26 AKT1 KIT MUSK STK16
7 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.62 CD1B CD1E

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.65 AKT1 KIT MUSK STK16 TTN
2 lipopeptide binding GO:0071723 9.16 CD1B CD1E
3 endogenous lipid antigen binding GO:0030883 8.96 CD1B CD1E
4 exogenous lipid antigen binding GO:0030884 8.62 CD1B CD1E
5 protein binding GO:0005515 10.22 AIRE AKT1 AMPH CD1B CD5 CNTNAP2

Sources for Thymus Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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