Thymus Gland Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease ¹² ¹⁵

Disease of Thymus Gland ¹²

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Diseases of thymus

Disease of thymus, unspecified

External Ids:

Disease Ontology ¹² DOID:533

ICD9CM ³⁶ 254 254.9

NCIt ⁵¹ C26962

SNOMED-CT ⁶⁹ 20673009

ICD10 ³⁴ E32 E32.9

UMLS ⁷⁴ C0154199

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Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to dendritic cell thymoma and thymic epithelial tumor. An important gene associated with Thymus Gland Disease is TTN (Titin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Jak-Stat Signaling Pathway (sino). Affiliated tissues include thymus and myeloid, and related phenotypes are Decreased viability and Decreased viability

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Related Diseases for Thymus Gland Disease

Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)

#	Related Disease	Score	Top Affiliating Genes
1	dendritic cell thymoma	10.4	CD5 TTN
2	thymic epithelial tumor	10.3	CD5 KIT
3	maxillary sinus adenoid cystic carcinoma	10.3	IL2 KIT
4	ectopic thymus	10.3	CD5 OMG
5	mixed type thymoma	10.3	CD5 KIT
6	lymphatic system disease	10.3	CD5 IL2 TTN
7	ocular melanoma	10.2	IL2 KIT
8	lymphoepithelioma-like thymic carcinoma	10.2	CD5 KIT
9	hepatic angiomyolipoma	10.2	KIT MTOR
10	postsynaptic congenital myasthenic syndromes	10.2	LRP4 MUSK
11	gastrointestinal system disease	10.1	AKT1 IL2 KIT
12	myasthenia gravis	10.1	AIRE IL2 MUSK TTN
13	leukocyte disease	10.1	AKT1 CD5 IL2 KIT
14	neuromuscular junction disease	10.0	LRP4 MUSK OMG TTN
15	mediastinal cancer	10.0	CD5 KIT
16	hematologic cancer	10.0	CD5 IL2 KIT MTOR
17	mycobacterium malmoense	10.0	CD1B CD1E
18	mantle cell lymphoma	9.9	AKT1 CD5 MTOR
19	leukemia, acute myeloid	9.8	AKT1 IL2 KIT MTOR
20	thymus cancer	9.3	AMPH CD5 CNTNAP2 DPYSL5 KIT PSMB11
21	thymoma	8.7	AIRE AKT1 AMPH CD5 DPYSL5 IL2

Graphical network of the top 20 diseases related to Thymus Gland Disease:

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Symptoms & Phenotypes for Thymus Gland Disease

GenomeRNAi Phenotypes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

²⁷ (show all 38)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability	GR00055-A-2	10.39	MTOR MUSK
2	Decreased viability	GR00173-A	10.39	MUSK
3	Decreased viability	GR00221-A-1	10.39	AKT1 KIT MTOR MUSK STK16
4	Decreased viability	GR00221-A-2	10.39	AKT1 STK16 TTN
5	Decreased viability	GR00221-A-3	10.39	AKT1 STK16
6	Decreased viability	GR00221-A-4	10.39	AKT1 MTOR MUSK STK16 TTN
7	Decreased viability	GR00301-A	10.39	KIT
8	Decreased viability	GR00342-S-1	10.39	MTOR STK16 TTN
9	Decreased viability	GR00342-S-2	10.39	MTOR
10	Decreased viability	GR00342-S-3	10.39	STK16 TTN
11	Decreased viability	GR00402-S-2	10.39	AKT1 KIT MTOR MUSK STK16 TTN
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-102	9.88	KIT
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.88	MTOR
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-11	9.88	MTOR
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.88	MUSK
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-152	9.88	KIT
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-157	9.88	KIT
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.88	AKT1 MTOR
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-161	9.88	AIRE MUSK
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-170	9.88	KIT
21	Increased shRNA abundance (Z-score > 2)	GR00366-A-177	9.88	AKT1
22	Increased shRNA abundance (Z-score > 2)	GR00366-A-185	9.88	AIRE
23	Increased shRNA abundance (Z-score > 2)	GR00366-A-199	9.88	MUSK
24	Increased shRNA abundance (Z-score > 2)	GR00366-A-208	9.88	MUSK
25	Increased shRNA abundance (Z-score > 2)	GR00366-A-30	9.88	KIT
26	Increased shRNA abundance (Z-score > 2)	GR00366-A-32	9.88	MUSK
27	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.88	AKT1 KIT MTOR
28	Increased shRNA abundance (Z-score > 2)	GR00366-A-46	9.88	MUSK
29	Increased shRNA abundance (Z-score > 2)	GR00366-A-49	9.88	AIRE
30	Increased shRNA abundance (Z-score > 2)	GR00366-A-50	9.88	AKT1
31	Increased shRNA abundance (Z-score > 2)	GR00366-A-63	9.88	MUSK
32	Increased shRNA abundance (Z-score > 2)	GR00366-A-70	9.88	AKT1
33	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.88	MTOR
34	Increased shRNA abundance (Z-score > 2)	GR00366-A-79	9.88	AKT1 MUSK
35	Increased shRNA abundance (Z-score > 2)	GR00366-A-80	9.88	AIRE
36	Increased shRNA abundance (Z-score > 2)	GR00366-A-85	9.88	AIRE AKT1 KIT MTOR MUSK
37	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	9.88	KIT
38	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	9.88	KIT

MGI Mouse Phenotypes related to Thymus Gland Disease:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.07	AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2	nervous system	MP:0003631	9.9	AIRE AKT1 AMPH CD5 CNTNAP2 DPYSL5
3	no phenotypic analysis	MP:0003012	9.5	AIRE CD5 IL2 KIT MTOR OMG
4	respiratory system	MP:0005388	9.17	AIRE AKT1 IL2 KIT LRP4 MTOR

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Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

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Genetic Tests for Thymus Gland Disease

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Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

⁴²

Thymus, Myeloid

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Publications for Thymus Gland Disease

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Genes for Thymus Gland Disease

Genes related to Thymus Gland Disease (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TTN	Titin	Protein Coding	17.32	DISEASES inferred ¹⁵
2	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	17.07	DISEASES inferred ¹⁵
3	CD5	CD5 Molecule	Protein Coding	16.89	DISEASES inferred ¹⁵
4	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	16.77	DISEASES inferred ¹⁵
5	IL2	Interleukin 2	Protein Coding	16.2	DISEASES inferred ¹⁵
6	KCNA4	Potassium Voltage-Gated Channel Subfamily A Member 4	Protein Coding	16.16	DISEASES inferred ¹⁵
7	AIRE	Autoimmune Regulator	Protein Coding	15.89	DISEASES inferred ¹⁵
8	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	15.84	DISEASES inferred ¹⁵
9	CNTNAP2	Contactin Associated Protein Like 2	Protein Coding	15.74	DISEASES inferred ¹⁵
10	OMG	Oligodendrocyte Myelin Glycoprotein	Protein Coding	15.53	DISEASES inferred ¹⁵
11	CD1E	CD1e Molecule	Protein Coding	15.5	DISEASES inferred ¹⁵
12	LRP4	LDL Receptor Related Protein 4	Protein Coding	15.49	DISEASES inferred ¹⁵
13	MTOR	Mechanistic Target Of Rapamycin Kinase	Protein Coding	15.41	DISEASES inferred ¹⁵
14	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	6.39	DISEASES inferred ¹⁵
15	TSR1	TSR1 Ribosome Maturation Factor	Protein Coding	6.19	DISEASES inferred ¹⁵
16	PSMB11	Proteasome Subunit Beta 11	Protein Coding	6.14	DISEASES inferred ¹⁵
17	AMPH	Amphiphysin	Protein Coding	5.54	DISEASES inferred ¹⁵
18	CD1B	CD1b Molecule	Protein Coding	5.52	DISEASES inferred ¹⁵
19	STK16	Serine/Threonine Kinase 16	Protein Coding	5.48	DISEASES inferred ¹⁵

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Variations for Thymus Gland Disease

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Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

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Pathways for Thymus Gland Disease

Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.61	CD5 IL2 KIT
2	Jak-Stat Signaling Pathway (sino) ⁶⁸	11.52	AKT1 IL2 MTOR
3	IL2 signaling events mediated by PI3K ¹ Show member pathways IL2 signaling events mediated by STAT5 ¹	11.26	AKT1 IL2 MTOR
4	Regulation of Telomerase ¹	11.15	AKT1 IL2 MTOR
5	Central carbon metabolism in cancer ³⁸	10.94	AKT1 KIT MTOR
6	Hematopoietic cell lineage ³⁸	10.91	CD1B CD1E CD5 KIT
7	4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression ¹	10.58	AKT1 MTOR

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GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	8.92	CD1B CNTNAP2 KIT LRP4

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of gene expression	GO:0010628	9.8	AKT1 KIT MTOR MUSK TTN
2	phosphorylation	GO:0016310	9.73	AKT1 KIT MTOR MUSK STK16 TTN
3	positive regulation of protein phosphorylation	GO:0001934	9.67	AKT1 IL2 MTOR MUSK
4	peptidyl-tyrosine phosphorylation	GO:0018108	9.62	KIT MUSK STK16 TTN
5	positive regulation of lipid biosynthetic process	GO:0046889	9.56	AKT1 MTOR
6	regulation of myelination	GO:0031641	9.55	AKT1 MTOR
7	TOR signaling	GO:0031929	9.54	AKT1 MTOR
8	negative regulation of macroautophagy	GO:0016242	9.52	AKT1 MTOR
9	anoikis	GO:0043276	9.51	AKT1 MTOR
10	negative regulation of cell size	GO:0045792	9.49	AKT1 MTOR
11	skeletal muscle acetylcholine-gated channel clustering	GO:0071340	9.48	LRP4 MUSK
12	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	9.46	CD1B CD1E
13	regulation of glycogen biosynthetic process	GO:0005979	9.43	AKT1 MTOR
14	protein phosphorylation	GO:0006468	9.43	AKT1 KIT MTOR MUSK STK16 TTN
15	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	9.16	CD1B CD1E
16	protein autophosphorylation	GO:0046777	9.02	AKT1 KIT MTOR MUSK STK16

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	kinase activity	GO:0016301	9.73	AKT1 KIT MTOR MUSK STK16 TTN
2	lipopeptide binding	GO:0071723	9.32	CD1B CD1E
3	endogenous lipid antigen binding	GO:0030883	9.16	CD1B CD1E
4	protein kinase activity	GO:0004672	9.1	AKT1 KIT MTOR MUSK STK16 TTN
5	exogenous lipid antigen binding	GO:0030884	8.96	CD1B CD1E

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Sources for Thymus Gland Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹⁶ DrugBank

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¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

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⁴⁹ NCBI Bookshelf

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⁵¹ NCIt

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⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

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⁶⁹ SNOMED-CT

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⁷² TGDB

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⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia