Thymus Gland Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease ¹² ¹⁵

Disease of Thymus Gland ¹²

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Diseases of thymus

Disease of thymus, unspecified

External Ids:

Disease Ontology ¹² DOID:533

ICD9CM ³⁵ 254 254.9

NCIt ⁵⁰ C26962

SNOMED-CT ⁶⁸ 20673009

ICD10 ³³ E32 E32.9

UMLS ⁷² C0154199

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Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to dendritic cell thymoma and thymic epithelial tumor. An important gene associated with Thymus Gland Disease is TTN (Titin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and T cell receptor signaling pathway. Affiliated tissues include thymus, and related phenotypes are behavior/neurological and nervous system

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Related Diseases for Thymus Gland Disease

Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)

#	Related Disease	Score	Top Affiliating Genes
1	dendritic cell thymoma	10.6	TTN CD5
2	thymic epithelial tumor	10.5	KIT CD5
3	metal allergy	10.5	CD8A CD4
4	maxillary sinus adenoid cystic carcinoma	10.5	KIT IL2
5	mixed type thymoma	10.5	KIT CD5
6	polyclonal hypergammaglobulinemia	10.5	CD8A CD4
7	ocular melanoma	10.4	KIT IL2
8	lymphatic system disease	10.4	TTN IL2 CD5
9	lymphoepithelioma-like thymic carcinoma	10.4	KIT CD5
10	immunodysregulation, polyendocrinopathy, and enteropathy, x-linked	10.3	IL2 CD4 AIRE
11	mediastinal cancer	10.3	KIT CD5
12	myasthenia gravis	10.2	TTN MUSK IL2 AIRE
13	gastrointestinal system disease	10.2	KIT IL2 AKT1
14	leukocyte disease	10.1	KIT IL2 CD5 AKT1
15	multifocal motor neuropathy	10.0	CD1E CD1A
16	murray valley encephalitis	10.0	THY1 IL2
17	diverticulitis of colon	9.9	KIT CD1A
18	mycobacterium malmoense	9.2	CD1E CD1C CD1B CD1A
19	thymus cancer	9.0	PSMB11 KIT DPYSL5 CNTNAP2 CD5 AMPH
20	thymus lipoma	8.9	CD8A CD5 CD4 CD1C CD1B CD1A
21	immune system organ benign neoplasm	8.9	CD8A CD5 CD4 CD1C CD1B CD1A
22	thymoma	7.9	TTN THY1 PSMB11 KIT IL2 DPYSL5

Graphical network of the top 20 diseases related to Thymus Gland Disease:

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Symptoms & Phenotypes for Thymus Gland Disease

MGI Mouse Phenotypes related to Thymus Gland Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.85	AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2	nervous system	MP:0003631	9.73	AIRE AKT1 AMPH CD4 CD5 CD8A
3	normal	MP:0002873	9.23	AIRE AKT1 CD4 CD5 CD8A KIT

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Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

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Genetic Tests for Thymus Gland Disease

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Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

⁴¹

Thymus

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Publications for Thymus Gland Disease

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Genes for Thymus Gland Disease

Genes related to Thymus Gland Disease (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TTN	Titin	Protein Coding	17.22	DISEASES inferred ¹⁵
2	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	17	DISEASES inferred ¹⁵
3	CD5	CD5 Molecule	Protein Coding	16.84	DISEASES inferred ¹⁵
4	CD8A	CD8a Molecule	Protein Coding	16.8	DISEASES inferred ¹⁵
5	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	16.67	DISEASES inferred ¹⁵
6	CD4	CD4 Molecule	Protein Coding	16.61	DISEASES inferred ¹⁵
7	IL2	Interleukin 2	Protein Coding	16.13	DISEASES inferred ¹⁵
8	AIRE	Autoimmune Regulator	Protein Coding	16.06	DISEASES inferred ¹⁵
9	KCNA4	Potassium Voltage-Gated Channel Subfamily A Member 4	Protein Coding	16.01	DISEASES inferred ¹⁵
10	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	15.91	DISEASES inferred ¹⁵
11	CNTNAP2	Contactin Associated Protein Like 2	Protein Coding	15.74	DISEASES inferred ¹⁵
12	CD1A	CD1a Molecule	Protein Coding	15.53	DISEASES inferred ¹⁵
13	CD1E	CD1e Molecule	Protein Coding	15.48	DISEASES inferred ¹⁵
14	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	6.24	DISEASES inferred ¹⁵
15	TSR1	TSR1 Ribosome Maturation Factor	Protein Coding	6.05	DISEASES inferred ¹⁵
16	PSMB11	Proteasome Subunit Beta 11	Protein Coding	5.96	DISEASES inferred ¹⁵
17	CD1B	CD1b Molecule	Protein Coding	5.49	DISEASES inferred ¹⁵
18	THY1	Thy-1 Cell Surface Antigen	Protein Coding	5.47	DISEASES inferred ¹⁵
19	CD1C	CD1c Molecule	Protein Coding	5.38	DISEASES inferred ¹⁵
20	AMPH	Amphiphysin	Protein Coding	5.36	DISEASES inferred ¹⁵

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Variations for Thymus Gland Disease

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Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

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Pathways for Thymus Gland Disease

Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Class I MHC mediated antigen processing and presentation ⁶⁶ Show member pathways Adaptive Immune System ⁶⁶ Antigen processing- Ubiquitination and Proteasome degradation ⁶⁶	13.26	PSMB11 KIT CD8A CD4 CD1C CD1B
2	T cell receptor signaling pathway ³⁷ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁷ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.35	IL2 CD8A CD4 AKT1
3	Tight junction ³⁷	11.99	CD1E CD1C CD1B CD1A
4	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell ⁶⁶	11.86	CD8A CD1C CD1B CD1A
5	IL12-mediated signaling events ¹ Show member pathways Immune response IL-12-induced IFN-gamma production ²²	11.77	IL2 CD8A CD4
6	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.76	THY1 KIT IL2 CD8A CD5 CD4
7	TCR signaling in naive CD4+ T cells ¹ Show member pathways TCR signaling in naive CD8+ T cells ¹	11.73	CD8A CD4 AKT1
8	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.62	THY1 KIT IL2 CD8A CD4
9	CTLA4 Signaling ⁶⁴	11.52	CD8A CD4 AKT1
10	B Cell Development Pathways ⁶⁵	11.38	THY1 KIT CD5 CD4 CD1C
11	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.37	THY1 KIT IL2 CD8A CD4 CD1C
12	Hematopoietic cell lineage ³⁷	11.21	KIT CD8A CD5 CD4 CD1E CD1C
13	Primary immunodeficiency ³⁷	11.15	CD8A CD4 AIRE
14	T-Cell Receptor and Co-stimulatory Signaling ¹	11.04	IL2 CD8A AKT1

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GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.65	THY1 MUSK KIT KCNA4 CD8A CD5
2	external side of plasma membrane	GO:0009897	9.55	THY1 KIT CD8A CD5 CD4
3	T cell receptor complex	GO:0042101	9.37	CD8A CD4
4	axolemma	GO:0030673	9.32	THY1 CNTNAP2
5	cell surface	GO:0009986	9.02	THY1 KIT CNTNAP2 CD4 CD1B
6	plasma membrane	GO:0005886	10.07	THY1 MUSK KIT KCNA4 CD8A CD5

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune system process	GO:0002376	9.91	IL2 CD8A CD4 CD1E CD1C CD1B
2	cytokine-mediated signaling pathway	GO:0019221	9.83	KIT IL2 CD4 AKT1
3	regulation of immune response	GO:0050776	9.8	CD8A CD1C CD1B CD1A
4	adaptive immune response	GO:0002250	9.8	IL2 CD4 CD1E CD1C CD1B CD1A
5	positive regulation of protein phosphorylation	GO:0001934	9.78	MUSK IL2 CD4 AKT1
6	protein autophosphorylation	GO:0046777	9.76	THY1 MUSK KIT AKT1
7	immune response	GO:0006955	9.76	IL2 CD8A CD4 CD1E CD1C CD1B
8	transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	9.71	MUSK KIT CD8A CD4
9	T cell differentiation	GO:0030217	9.61	KIT IL2 CD4
10	positive regulation of T cell mediated cytotoxicity	GO:0001916	9.56	CD1E CD1C CD1B CD1A
11	positive regulation of kinase activity	GO:0033674	9.54	IL2 CD4
12	cellular response to granulocyte macrophage colony-stimulating factor stimulus	GO:0097011	9.51	CD4 AKT1
13	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	9.26	CD1E CD1C CD1B CD1A
14	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	8.92	CD1E CD1C CD1B CD1A

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase binding	GO:0019901	9.77	TTN THY1 CD8A CD4 AKT1
2	enzyme binding	GO:0019899	9.65	TTN THY1 CNTNAP2 CD4 AKT1
3	lipopeptide binding	GO:0071723	9.46	CD1E CD1C CD1B CD1A
4	transmembrane signaling receptor activity	GO:0004888	9.32	CD5 CD4
5	exogenous lipid antigen binding	GO:0030884	9.26	CD1E CD1C CD1B CD1A
6	endogenous lipid antigen binding	GO:0030883	8.92	CD1E CD1C CD1B CD1A
7	protein binding	GO:0005515	10.31	TTN THY1 MUSK KIT KCNA4 IL2

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Sources for Thymus Gland Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia