Thymus Gland Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease ¹² ¹⁵

Disease of Thymus Gland ¹²

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases Immune diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Diseases of thymus

Disease of thymus, unspecified

External Ids:

Disease Ontology ¹² DOID:533

ICD9CM ³⁶ 254 254.9

NCIt ⁵¹ C26962

SNOMED-CT ⁶⁹ 20673009

ICD10 ³⁴ E32 E32.9

UMLS ⁷⁴ C0154199

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Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to thymic epithelial tumor and dendritic cell thymoma. An important gene associated with Thymus Gland Disease is TTN (Titin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. Affiliated tissues include thymus, and related phenotypes are behavior/neurological and nervous system

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Related Diseases for Thymus Gland Disease

Diseases related to Thymus Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)

#	Related Disease	Score	Top Affiliating Genes
1	thymic epithelial tumor	10.4	CD5 KIT
2	dendritic cell thymoma	10.4	CD5 TTN
3	maxillary sinus adenoid cystic carcinoma	10.3	IL2 KIT
4	splenic tuberculosis	10.3	IL2 SMUG1
5	pharynx squamous cell carcinoma	10.3	AKT1 SMUG1
6	prostate lymphoma	10.3	CD5 SMUG1
7	breast lymphoma	10.3	CD5 SMUG1
8	ectopic thymus	10.3	CD5 OMG
9	mixed type thymoma	10.3	CD5 KIT
10	ocular melanoma	10.2	IL2 KIT
11	mediastinal cancer	10.2	CD5 KIT SMUG1
12	lymphoepithelioma-like thymic carcinoma	10.2	CD5 KIT
13	pharynx cancer	10.2	AKT1 KIT SMUG1
14	connective tissue cancer	10.2	AKT1 KIT SMUG1
15	intestinal disease	10.2	AKT1 IL2 SMUG1
16	myasthenia gravis	10.2	AIRE IL2 MUSK TTN
17	granulomatous myositis	10.2	SMUG1 TTN
18	lymphatic system disease	10.1	CD5 IL2 SMUG1 TTN
19	respiratory system disease	10.1	AKT1 IL2 SMUG1
20	gastrointestinal system cancer	10.1	AKT1 KIT SMUG1
21	muscular disease	10.1	AKT1 KIT SMUG1 TTN
22	gastrointestinal system disease	10.1	AKT1 IL2 KIT SMUG1
23	postsynaptic congenital myasthenic syndromes	10.1	LRP4 MUSK
24	myeloma, multiple	10.1	AKT1 IL2 KIT SMUG1
25	neuromuscular junction disease	10.1	LRP4 MUSK OMG TTN
26	leukocyte disease	10.0	AKT1 CD5 IL2 KIT SMUG1
27	breast angiosarcoma	10.0	KIT SMUG1
28	mycobacterium malmoense	9.9	CD1B CD1E
29	thymus cancer	9.0	AMPH CD5 CNTNAP2 DPYSL5 KIT PSMB11
30	thymoma	9.0	AIRE AKT1 AMPH CD5 DPYSL5 IL2

Graphical network of the top 20 diseases related to Thymus Gland Disease:

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Symptoms & Phenotypes for Thymus Gland Disease

MGI Mouse Phenotypes related to Thymus Gland Disease:

⁴⁷

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.93	AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2	nervous system	MP:0003631	9.7	AIRE AKT1 AMPH CD5 CNTNAP2 DPYSL5
3	respiratory system	MP:0005388	9.17	AIRE AKT1 IL2 KIT LRP4 MUSK

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Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

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Genetic Tests for Thymus Gland Disease

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Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

⁴²

Thymus

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Publications for Thymus Gland Disease

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Genes for Thymus Gland Disease

Genes related to Thymus Gland Disease (0 elite genes):

(show all 20)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TTN	Titin	Protein Coding	17.31	DISEASES inferred ¹⁵
2	MUSK	Muscle Associated Receptor Tyrosine Kinase	Protein Coding	17.07	DISEASES inferred ¹⁵
3	CD5	CD5 Molecule	Protein Coding	16.87	DISEASES inferred ¹⁵
4	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	16.75	DISEASES inferred ¹⁵
5	IL2	Interleukin 2	Protein Coding	16.2	DISEASES inferred ¹⁵
6	KCNA4	Potassium Voltage-Gated Channel Subfamily A Member 4	Protein Coding	16.07	DISEASES inferred ¹⁵
7	AIRE	Autoimmune Regulator	Protein Coding	15.89	DISEASES inferred ¹⁵
8	KIT	KIT Proto-Oncogene, Receptor Tyrosine Kinase	Protein Coding	15.82	DISEASES inferred ¹⁵
9	CNTNAP2	Contactin Associated Protein Like 2	Protein Coding	15.73	DISEASES inferred ¹⁵
10	TCOF1	Treacle Ribosome Biogenesis Factor 1	Protein Coding	15.67	DISEASES inferred ¹⁵
11	SMUG1	Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1	Protein Coding	15.59	DISEASES inferred ¹⁵
12	OMG	Oligodendrocyte Myelin Glycoprotein	Protein Coding	15.54	DISEASES inferred ¹⁵
13	LRP4	LDL Receptor Related Protein 4	Protein Coding	15.51	DISEASES inferred ¹⁵
14	CD1E	CD1e Molecule	Protein Coding	15.5	DISEASES inferred ¹⁵
15	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	6.39	DISEASES inferred ¹⁵
16	TSR1	TSR1 Ribosome Maturation Factor	Protein Coding	6.18	DISEASES inferred ¹⁵
17	PSMB11	Proteasome Subunit Beta 11	Protein Coding	6.13	DISEASES inferred ¹⁵
18	AMPH	Amphiphysin	Protein Coding	5.54	DISEASES inferred ¹⁵
19	CD1B	CD1b Molecule	Protein Coding	5.52	DISEASES inferred ¹⁵
20	STK16	Serine/Threonine Kinase 16	Protein Coding	5.48	DISEASES inferred ¹⁵

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Variations for Thymus Gland Disease

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Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

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Pathways for Thymus Gland Disease

Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	11.2	CD5 IL2 KIT
2	Hematopoietic cell lineage ³⁸	10.91	CD1B CD1E CD5 KIT

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GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell surface	GO:0009986	9.02	CD1B CD1E CNTNAP2 KIT LRP4

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein phosphorylation	GO:0006468	9.77	AKT1 KIT MUSK STK16 TTN
2	peptidyl-tyrosine phosphorylation	GO:0018108	9.46	KIT MUSK STK16 TTN
3	negative regulation of axonogenesis	GO:0050771	9.4	LRP4 OMG
4	skeletal muscle acetylcholine-gated channel clustering	GO:0071340	9.32	LRP4 MUSK
5	antigen processing and presentation, exogenous lipid antigen via MHC class Ib	GO:0048007	9.26	CD1B CD1E
6	protein autophosphorylation	GO:0046777	9.26	AKT1 KIT MUSK STK16
7	antigen processing and presentation, endogenous lipid antigen via MHC class Ib	GO:0048006	8.62	CD1B CD1E

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	protein kinase activity	GO:0004672	9.65	AKT1 KIT MUSK STK16 TTN
2	lipopeptide binding	GO:0071723	9.16	CD1B CD1E
3	endogenous lipid antigen binding	GO:0030883	8.96	CD1B CD1E
4	exogenous lipid antigen binding	GO:0030884	8.62	CD1B CD1E
5	protein binding	GO:0005515	10.22	AIRE AKT1 AMPH CD1B CD5 CNTNAP2

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Sources for Thymus Gland Disease

¹ BioSystems

² BitterDB

³ CDC

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⁵ ClinicalTrials

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⁸ Cochrane Library

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¹⁹ FDA Approved Drugs

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²¹ GeneAnalytics

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²³ GeneGo (Thomson Reuters)

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²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

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³¹ HGMD

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³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

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⁴⁵ MeSH

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⁴⁷ MGI

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⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

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⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

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⁷² TGDB

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⁷⁴ UMLS

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⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia