MCID: THY026
MIFTS: 25

Thymus Gland Disease

Categories: Endocrine diseases, Immune diseases

Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease 12 15
Disease of Thymus Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:533
ICD9CM 35 254 254.9
NCIt 50 C26962
SNOMED-CT 68 20673009
ICD10 33 E32 E32.9
UMLS 72 C0154199

Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to dendritic cell thymoma and thymic epithelial tumor. An important gene associated with Thymus Gland Disease is TTN (Titin), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and T cell receptor signaling pathway. Affiliated tissues include thymus, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Thymus Gland Disease

Graphical network of the top 20 diseases related to Thymus Gland Disease:



Diseases related to Thymus Gland Disease

Symptoms & Phenotypes for Thymus Gland Disease

MGI Mouse Phenotypes related to Thymus Gland Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2 nervous system MP:0003631 9.73 AIRE AKT1 AMPH CD4 CD5 CD8A
3 normal MP:0002873 9.23 AIRE AKT1 CD4 CD5 CD8A KIT

Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

Genetic Tests for Thymus Gland Disease

Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

41
Thymus

Publications for Thymus Gland Disease

Variations for Thymus Gland Disease

Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

Pathways for Thymus Gland Disease

Pathways related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 PSMB11 KIT CD8A CD4 CD1C CD1B
2
Show member pathways
12.35 IL2 CD8A CD4 AKT1
3 11.99 CD1E CD1C CD1B CD1A
4 11.86 CD8A CD1C CD1B CD1A
5
Show member pathways
11.77 IL2 CD8A CD4
6 11.76 THY1 KIT IL2 CD8A CD5 CD4
7
Show member pathways
11.73 CD8A CD4 AKT1
8 11.62 THY1 KIT IL2 CD8A CD4
9 11.52 CD8A CD4 AKT1
10 11.38 THY1 KIT CD5 CD4 CD1C
11 11.37 THY1 KIT IL2 CD8A CD4 CD1C
12 11.21 KIT CD8A CD5 CD4 CD1E CD1C
13 11.15 CD8A CD4 AIRE
14 11.04 IL2 CD8A AKT1

GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.65 THY1 MUSK KIT KCNA4 CD8A CD5
2 external side of plasma membrane GO:0009897 9.55 THY1 KIT CD8A CD5 CD4
3 T cell receptor complex GO:0042101 9.37 CD8A CD4
4 axolemma GO:0030673 9.32 THY1 CNTNAP2
5 cell surface GO:0009986 9.02 THY1 KIT CNTNAP2 CD4 CD1B
6 plasma membrane GO:0005886 10.07 THY1 MUSK KIT KCNA4 CD8A CD5

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.91 IL2 CD8A CD4 CD1E CD1C CD1B
2 cytokine-mediated signaling pathway GO:0019221 9.83 KIT IL2 CD4 AKT1
3 regulation of immune response GO:0050776 9.8 CD8A CD1C CD1B CD1A
4 adaptive immune response GO:0002250 9.8 IL2 CD4 CD1E CD1C CD1B CD1A
5 positive regulation of protein phosphorylation GO:0001934 9.78 MUSK IL2 CD4 AKT1
6 protein autophosphorylation GO:0046777 9.76 THY1 MUSK KIT AKT1
7 immune response GO:0006955 9.76 IL2 CD8A CD4 CD1E CD1C CD1B
8 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.71 MUSK KIT CD8A CD4
9 T cell differentiation GO:0030217 9.61 KIT IL2 CD4
10 positive regulation of T cell mediated cytotoxicity GO:0001916 9.56 CD1E CD1C CD1B CD1A
11 positive regulation of kinase activity GO:0033674 9.54 IL2 CD4
12 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.51 CD4 AKT1
13 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.26 CD1E CD1C CD1B CD1A
14 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.92 CD1E CD1C CD1B CD1A

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.77 TTN THY1 CD8A CD4 AKT1
2 enzyme binding GO:0019899 9.65 TTN THY1 CNTNAP2 CD4 AKT1
3 lipopeptide binding GO:0071723 9.46 CD1E CD1C CD1B CD1A
4 transmembrane signaling receptor activity GO:0004888 9.32 CD5 CD4
5 exogenous lipid antigen binding GO:0030884 9.26 CD1E CD1C CD1B CD1A
6 endogenous lipid antigen binding GO:0030883 8.92 CD1E CD1C CD1B CD1A
7 protein binding GO:0005515 10.31 TTN THY1 MUSK KIT KCNA4 IL2

Sources for Thymus Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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