MCID: THY026
MIFTS: 28

Thymus Gland Disease

Categories: Endocrine diseases, Immune diseases

Aliases & Classifications for Thymus Gland Disease

MalaCards integrated aliases for Thymus Gland Disease:

Name: Thymus Gland Disease 12 15
Disease of Thymus Gland 12

Classifications:



External Ids:

Disease Ontology 12 DOID:533
ICD9CM 36 254 254.9
NCIt 51 C26962
SNOMED-CT 69 20673009
ICD10 34 E32 E32.9
UMLS 74 C0154199

Summaries for Thymus Gland Disease

MalaCards based summary : Thymus Gland Disease, also known as disease of thymus gland, is related to dendritic cell thymoma and thymic epithelial tumor. An important gene associated with Thymus Gland Disease is TTN (Titin), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Jak-Stat Signaling Pathway (sino). Affiliated tissues include thymus and myeloid, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Thymus Gland Disease

Graphical network of the top 20 diseases related to Thymus Gland Disease:



Diseases related to Thymus Gland Disease

Symptoms & Phenotypes for Thymus Gland Disease

GenomeRNAi Phenotypes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

27 (show all 38)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.39 MTOR MUSK
2 Decreased viability GR00173-A 10.39 MUSK
3 Decreased viability GR00221-A-1 10.39 AKT1 KIT MTOR MUSK STK16
4 Decreased viability GR00221-A-2 10.39 AKT1 STK16 TTN
5 Decreased viability GR00221-A-3 10.39 AKT1 STK16
6 Decreased viability GR00221-A-4 10.39 AKT1 MTOR MUSK STK16 TTN
7 Decreased viability GR00301-A 10.39 KIT
8 Decreased viability GR00342-S-1 10.39 MTOR STK16 TTN
9 Decreased viability GR00342-S-2 10.39 MTOR
10 Decreased viability GR00342-S-3 10.39 STK16 TTN
11 Decreased viability GR00402-S-2 10.39 AKT1 KIT MTOR MUSK STK16 TTN
12 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.88 KIT
13 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.88 MTOR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.88 MTOR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.88 MUSK
16 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.88 KIT
17 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.88 KIT
18 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.88 AKT1 MTOR
19 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.88 AIRE MUSK
20 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.88 KIT
21 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.88 AKT1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-185 9.88 AIRE
23 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.88 MUSK
24 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.88 MUSK
25 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.88 KIT
26 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.88 MUSK
27 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.88 AKT1 KIT MTOR
28 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.88 MUSK
29 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.88 AIRE
30 Increased shRNA abundance (Z-score > 2) GR00366-A-50 9.88 AKT1
31 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.88 MUSK
32 Increased shRNA abundance (Z-score > 2) GR00366-A-70 9.88 AKT1
33 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.88 MTOR
34 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.88 AKT1 MUSK
35 Increased shRNA abundance (Z-score > 2) GR00366-A-80 9.88 AIRE
36 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.88 AIRE AKT1 KIT MTOR MUSK
37 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.88 KIT
38 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.88 KIT

MGI Mouse Phenotypes related to Thymus Gland Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.07 AIRE AKT1 AMPH CNTNAP2 DPYSL5 IL2
2 nervous system MP:0003631 9.9 AIRE AKT1 AMPH CD5 CNTNAP2 DPYSL5
3 no phenotypic analysis MP:0003012 9.5 AIRE CD5 IL2 KIT MTOR OMG
4 respiratory system MP:0005388 9.17 AIRE AKT1 IL2 KIT LRP4 MTOR

Drugs & Therapeutics for Thymus Gland Disease

Search Clinical Trials , NIH Clinical Center for Thymus Gland Disease

Genetic Tests for Thymus Gland Disease

Anatomical Context for Thymus Gland Disease

MalaCards organs/tissues related to Thymus Gland Disease:

42
Thymus, Myeloid

Publications for Thymus Gland Disease

Variations for Thymus Gland Disease

Expression for Thymus Gland Disease

Search GEO for disease gene expression data for Thymus Gland Disease.

Pathways for Thymus Gland Disease

GO Terms for Thymus Gland Disease

Cellular components related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 CD1B CNTNAP2 KIT LRP4

Biological processes related to Thymus Gland Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.8 AKT1 KIT MTOR MUSK TTN
2 phosphorylation GO:0016310 9.73 AKT1 KIT MTOR MUSK STK16 TTN
3 positive regulation of protein phosphorylation GO:0001934 9.67 AKT1 IL2 MTOR MUSK
4 peptidyl-tyrosine phosphorylation GO:0018108 9.62 KIT MUSK STK16 TTN
5 positive regulation of lipid biosynthetic process GO:0046889 9.56 AKT1 MTOR
6 regulation of myelination GO:0031641 9.55 AKT1 MTOR
7 TOR signaling GO:0031929 9.54 AKT1 MTOR
8 negative regulation of macroautophagy GO:0016242 9.52 AKT1 MTOR
9 anoikis GO:0043276 9.51 AKT1 MTOR
10 negative regulation of cell size GO:0045792 9.49 AKT1 MTOR
11 skeletal muscle acetylcholine-gated channel clustering GO:0071340 9.48 LRP4 MUSK
12 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.46 CD1B CD1E
13 regulation of glycogen biosynthetic process GO:0005979 9.43 AKT1 MTOR
14 protein phosphorylation GO:0006468 9.43 AKT1 KIT MTOR MUSK STK16 TTN
15 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.16 CD1B CD1E
16 protein autophosphorylation GO:0046777 9.02 AKT1 KIT MTOR MUSK STK16

Molecular functions related to Thymus Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.73 AKT1 KIT MTOR MUSK STK16 TTN
2 lipopeptide binding GO:0071723 9.32 CD1B CD1E
3 endogenous lipid antigen binding GO:0030883 9.16 CD1B CD1E
4 protein kinase activity GO:0004672 9.1 AKT1 KIT MTOR MUSK STK16 TTN
5 exogenous lipid antigen binding GO:0030884 8.96 CD1B CD1E

Sources for Thymus Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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