MCID: THY006
MIFTS: 27

Thymus Lymphoma

Categories: Blood diseases, Cancer diseases, Immune diseases

Aliases & Classifications for Thymus Lymphoma

MalaCards integrated aliases for Thymus Lymphoma:

Name: Thymus Lymphoma 12 15
Thymic Lymphoma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:10146
NCIt 50 C6451
UMLS 70 C1336745

Summaries for Thymus Lymphoma

MalaCards based summary : Thymus Lymphoma, also known as thymic lymphoma, is related to mediastinal malignant lymphoma and b-cell lymphoma. An important gene associated with Thymus Lymphoma is SETD4 (SET Domain Containing 4), and among its related pathways/superpathways are DNA Damage and Retinoblastoma (RB) in Cancer. Affiliated tissues include thymus, bone marrow and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Thymus Lymphoma

Diseases related to Thymus Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 mediastinal malignant lymphoma 9.8
2 b-cell lymphoma 9.8
3 shwachman-diamond syndrome 1 9.7 TP53 RPL29
4 alpha-thalassemia/mental retardation syndrome, x-linked 9.7 TP53 PRKDC
5 giant cell glioblastoma 9.7 TP53 TACC3
6 autosomal recessive cerebellar ataxia 9.7 TP53 PRKDC
7 hutchinson-gilford progeria syndrome 9.6 TP53 PRKDC
8 werner syndrome 9.5 TP53 PRKDC

Graphical network of the top 20 diseases related to Thymus Lymphoma:



Diseases related to Thymus Lymphoma

Symptoms & Phenotypes for Thymus Lymphoma

GenomeRNAi Phenotypes related to Thymus Lymphoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.28 SRM
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.28 SRM
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-169 9.28 TACC3 SRM
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-201 9.28 TACC3
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-5 9.28 PRKDC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-85 9.28 SRM

Drugs & Therapeutics for Thymus Lymphoma

Search Clinical Trials , NIH Clinical Center for Thymus Lymphoma

Genetic Tests for Thymus Lymphoma

Anatomical Context for Thymus Lymphoma

MalaCards organs/tissues related to Thymus Lymphoma:

40
Thymus, Bone Marrow, T Cells, Spleen, Myeloid, Thyroid, Spinal Cord

Publications for Thymus Lymphoma

Articles related to Thymus Lymphoma:

(show top 50) (show all 575)
# Title Authors PMID Year
1
Transplantation of Unirradiated Bone Marrow Cells after Total-Body Irradiation Prevents the Development of Thymic Lymphoma in Mice through Niche Competition. 61
33347573 2021
2
Novel Anticancer Dimeric Napthoquiones from Diospyros lotus Having Anti-Tumor, Anti-Inflammatory and Multidrug Resistance Reversal Potential: In Vitro, In Vivo and In Silico Evidence. 61
33438565 2021
3
CD4 and CD8 double-negative immunophenotype of thymoma-associated lymphocytes in a dog. 61
32814519 2020
4
53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice. 61
32139898 2020
5
Feasibility of using dynamic contrast-enhanced MRI for differentiating thymic carcinoma from thymic lymphoma based on semi-quantitative and quantitative models. 61
32197918 2020
6
A Novel Retrovirus (Gunnison's Prairie Dog Retrovirus) Associated With Thymic Lymphoma in Gunnison's Prairie Dogs in Colorado, USA. 61
32498297 2020
7
BW5147 and Derivatives for the Study of T Cells and their Antigen Receptors. 61
32419056 2020
8
Loss of Setd4 delays radiation-induced thymic lymphoma in mice. 61
31794893 2020
9
Analysis of miRNA-mRNA Crosstalk in Radiation-Induced Mouse Thymic Lymphomas to Identify miR-486 as a Critical Regulator by Targeting IGF2BP3 mRNA. 61
33692937 2020
10
Tracking the Fate of Endogenous Retrovirus Segregation in Wild and Domestic Cats. 61
31534037 2019
11
Conserved crosstalk between histone deacetylation and H3K79 methylation generates DOT1L-dose dependency in HDAC1-deficient thymic lymphoma. 61
31304633 2019
12
A novel RORγt inhibitor is a potential therapeutic agent for the topical treatment of psoriasis with low risk of thymic aberrations. 61
30905492 2019
13
In Vitro Mouse Lymphoma Cell (L5178Y Tk+/- -3.7.2.C) Forward Mutation Assay. 61
31473952 2019
14
Targeting Taurine Transporter (TauT) for Cancer Immunotherapy of p53 Mutation Mediated Cancers - Molecular Basis and Preclinical Implication. 61
31468430 2019
15
Preventive Effects of Fermented Brown Rice and Rice Bran on Spontaneous Lymphomagenesis in AKR/NSlc Female Mice 61
30486615 2018
16
Iodine Quantification Using Dual-Energy Computed Tomography for Differentiating Thymic Tumors. 61
30339550 2018
17
Modulating SIRT1 activity variously affects thymic lymphoma development in mice. 61
30059665 2018
18
T-cell Thymic Lymphoma With Proventricular Metastasis in a Florida Scrub Jay ( Aphelocoma coerulescens). 61
29905106 2018
19
Disparate effects of Shb gene deficiency on disease characteristics in murine models of myeloid, B-cell, and T-cell leukemia. 61
29792386 2018
20
A role for caspase-2 in sphingosine kinase 1 proteolysis in response to doxorubicin in breast cancer cells - implications for the CHK1-suppressed pathway. 61
29321954 2018
21
Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice. 61
28943948 2017
22
Down regulation of miR-143 promotes radiation - Induced thymic lymphoma by targeting B7H1. 61
28736328 2017
23
A two-amino-acid substitution in the transcription factor RORγt disrupts its function in TH17 differentiation but not in thymocyte development. 61
28846085 2017
24
FIR haplodeficiency promotes splicing to pyruvate kinase M2 in mice thymic lymphoma tissues revealed by six-plex tandem mass tag quantitative proteomic analysis. 61
28978087 2017
25
Response of mouse thymic cells to radiation after transfusion of mesenchymal stem cells. 61
28002319 2016
26
Absence of ERK5/MAPK7 delays tumorigenesis in Atm-/- mice. 61
27793024 2016
27
Mouse models for radiation-induced cancers. 61
27209205 2016
28
Nucks1 synergizes with Trp53 to promote radiation lymphomagenesis in mice. 61
27542204 2016
29
Ribosomal Protein Rpl22 Controls the Dissemination of T-cell Lymphoma. 61
27197189 2016
30
Suspected thymic lymphoma with invasion of the gills in a gold crossback arowana (Scleropages formosus). 61
26596259 2016
31
Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress. 61
26753883 2016
32
Co-Expression Network Analysis of Fbxw7-Associated LncRNAs Reveals Their Functions in Radiation-Induced Thymic Lymphoma. 61
27376155 2016
33
Microsatellite instability detected in tumor-related genes in C57BL/6J mice with thymic lymphoma induced by N-methyl-N-nitrosourea. 61
26498208 2015
34
A monoallelic-to-biallelic T-cell transcriptional switch regulates GATA3 abundance. 61
26385963 2015
35
Haploinsufficiency of Bcl11b suppresses the progression of ATM-deficient T cell lymphomas. 61
26219558 2015
36
Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration. 61
26190111 2015
37
Radiation-driven lipid accumulation and dendritic cell dysfunction in cancer. 61
25923834 2015
38
The role of DNA damage responses in p53 biology. 61
25618545 2015
39
Quantifying initial cellular events of mouse radiation lymphomagenesis and its tumor prevention in vivo by positron emission tomography and magnetic resonance imaging. 61
25510653 2015
40
Brca2 deficiency leads to T cell loss and immune dysfunction. 61
25666348 2015
41
Long-term Management of Thymic Lymphoma in a Java Sparrow (Lonchura oryzivora). 61
25867667 2015
42
Haploinsufficiency of the c-myc transcriptional repressor FIR, as a dominant negative-alternative splicing model, promoted p53-dependent T-cell acute lymphoblastic leukemia progression by activating Notch1. 61
25671302 2015
43
[Alternative Splicing Detection as Biomarker Candidates for Cancer Diagnosis and Treatment with Establishment of Clinical Biobank in Chiba University]. 61
26524858 2015
44
Analysis of the relationship between microsatellite instability and thymic lymphoma induced by N-methyl-N-nitrosourea in C57BL/6J mice. 61
25771976 2015
45
MiR-467a is upregulated in radiation-induced mouse thymic lymphomas and regulates apoptosis by targeting Fas and Bax. 61
25552935 2015
46
Spontaneous development of neoplasms in severe combined immunodeficient mice. 61
27489678 2015
47
Genetic background influences loss of heterozygosity patterns in radiation-induced mouse thymic lymphoma. 61
25932465 2015
48
Vaccination with OVA-bound nanoparticles encapsulating IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo. 61
25394516 2015
49
The evolution of thymic lymphomas in p53 knockout mice. 61
25452272 2014
50
MCL-1 but not BCL-XL is critical for the development and sustained expansion of thymic lymphoma in p53-deficient mice. 61
25368374 2014

Variations for Thymus Lymphoma

Expression for Thymus Lymphoma

Search GEO for disease gene expression data for Thymus Lymphoma.

Pathways for Thymus Lymphoma

Pathways related to Thymus Lymphoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.8 TP53 TACC3 PRKDC
2 11.27 TP53 PRKDC
3 11.08 TP53 PRKDC
4 10.45 TP53 TACC3
5 10.09 TP53 PRKDC

GO Terms for Thymus Lymphoma

Cellular components related to Thymus Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.1 TP53 TACC3 SRM SETD4 RPL29 PRKDC

Biological processes related to Thymus Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-strand break repair GO:0006302 9.37 TP53 PRKDC
2 somitogenesis GO:0001756 9.32 TP53 PRKDC
3 T cell differentiation in thymus GO:0033077 9.26 TP53 PRKDC
4 response to gamma radiation GO:0010332 9.16 TP53 PRKDC
5 T cell lineage commitment GO:0002360 8.96 TP53 PRKDC
6 B cell lineage commitment GO:0002326 8.62 TP53 PRKDC

Sources for Thymus Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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