MCID: THY027
MIFTS: 24

Thymus Squamous Cell Carcinoma

Categories: Cancer diseases, Endocrine diseases, Immune diseases, Skin diseases

Aliases & Classifications for Thymus Squamous Cell Carcinoma

MalaCards integrated aliases for Thymus Squamous Cell Carcinoma:

Name: Thymus Squamous Cell Carcinoma 12 15
Thymic Squamous Cell Carcinoma 72
Epidermoid Thymic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5530
NCIt 50 C6455
UMLS 72 C1336082

Summaries for Thymus Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the thymus.

MalaCards based summary : Thymus Squamous Cell Carcinoma, also known as thymic squamous cell carcinoma, is related to squamous cell carcinoma, and has symptoms including fever, fatigue and chest pain. An important gene associated with Thymus Squamous Cell Carcinoma is FOXN1 (Forkhead Box N1). Affiliated tissues include thymus, lung and brain.

Related Diseases for Thymus Squamous Cell Carcinoma

Diseases related to Thymus Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.3

Symptoms & Phenotypes for Thymus Squamous Cell Carcinoma

UMLS symptoms related to Thymus Squamous Cell Carcinoma:


fever, fatigue, chest pain, coughing

Drugs & Therapeutics for Thymus Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Thymus Squamous Cell Carcinoma

Genetic Tests for Thymus Squamous Cell Carcinoma

Anatomical Context for Thymus Squamous Cell Carcinoma

MalaCards organs/tissues related to Thymus Squamous Cell Carcinoma:

41
Thymus, Lung, Brain, Bone, Thyroid, Skeletal Muscle, Pituitary

The Foundational Model of Anatomy Ontology organs/tissues related to Thymus Squamous Cell Carcinoma:

19
Thymus

Publications for Thymus Squamous Cell Carcinoma

Articles related to Thymus Squamous Cell Carcinoma:

(show all 47)
# Title Authors PMID Year
1
A mutation analysis of the EGFR pathway genes, RAS, EGFR, PIK3CA, AKT1, and BRAF, and TP53 gene in thymic carcinoma and thymoma type A/B3. 38
31179560 2019
2
EGFR exon 20 insertion mutation in advanced thymic squamous cell carcinoma: Response to apatinib and clinical outcomes. 38
29740957 2018
3
An immunohistochemical panel consisting of EZH2, C-KIT, and CD205 is useful for distinguishing thymic squamous cell carcinoma from type B3 thymoma. 38
29487009 2018
4
Robot-assisted en bloc anterior mediastinal mass excision with pericardium and adjacent lung for locally advanced thymic carcinoma. 38
29963404 2018
5
Superior vena cava reconstruction under the left internal jugular vein to left femoral vein bypass support. 38
28410562 2017
6
Thymic Carcinoma With Endobronchial Metastasis: A Case Report. 38
28323731 2017
7
PD-L1, PD-1, CD4, and CD8 expression in neoplastic and nonneoplastic thymus. 38
27746267 2017
8
Middle mediastinal thymic carcinoma with cystic findings in radiologic images: a case report. 38
27822875 2016
9
AN INCIDENTAL FINDING OF THYMIC CARCINOMA DURING ELECTIVE CORONARY ARTERY BYPASS GRAFTING. 38
29693844 2016
10
Chemotherapy with gemcitabine plus cisplatin in patients with advanced thymic squamous cell carcinoma: Evaluation of efficacy and toxicity. 38
27042218 2016
11
Development of combined thymic carcinoma and thymoma in an extrathymic lesion during long follow-up for recurrent thymoma. 38
26893849 2016
12
FDG PET/CT Manifestation of Rare Widespread Metastatic Chemoradiation-Refractory Thymic Squamous Cell Carcinoma. 38
26252330 2015
13
The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. 38
26295375 2015
14
Immunohistochemical differentiation between type B3 thymomas and thymic squamous cell carcinomas. 38
26191237 2015
15
Two Cases of Thymic Carcinoma Initially Presenting as Bone Metastasis: A Clinical Report and the Usefulness of CD5 Immunohistochemistry for Assessing Bone Lesions. 38
26179536 2015
16
Genetic profiling of thymic carcinoma using targeted next-generation sequencing. 38
25249426 2014
17
[Clinical analysis of 11 cases of thymic squamous cell carcinoma]. 38
25030597 2014
18
[A case of postoperative thymic carcinoma recurrence that was effectively treated with combination chemotherapy of nedaplatin and docetaxel]. 38
24335370 2013
19
Analysis of MAML2 rearrangement in mucoepidermoid carcinoma of the thymus. 38
24134933 2013
20
Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases. 38
23866799 2013
21
Identification of novel mutations of TP53, ALK and RET gene in metastatic thymic squamous cell carcinoma and its therapeutic implication. 38
23639785 2013
22
Absence of gene mutations in KIT-positive carcinoma showing thymus-like elements of the thyroid. 38
21835435 2012
23
Erythrocytosis caused by erythropoietin-producing thymic carcinoma. 38
20179983 2010
24
Thymic squamous cell carcinoma with multiple brain metastases. 38
20714951 2010
25
Thymic squamous cell carcinoma producing granulocyte colony-stimulating factor associated with a high serum level of interleukin 6. 38
19967491 2009
26
Spontaneous mediastinal haemorrhage linked with thymic carcinoma and myelodysplasia: a case report. 38
19830017 2009
27
Multiple inflammatory cytokine-productive ThyL-6 cell line established from a patient with thymic carcinoma. 38
18691242 2008
28
Novel prognostic groups in thymic epithelial tumors: assessment of risk and therapeutic strategy selection. 38
18164843 2008
29
Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma. 38
17120029 2007
30
Thymic squamous cell carcinoma producing parathyroid hormone-related protein and CYFRA 21-1. 38
15283186 2004
31
Interleukin-6-producing thymic squamous cell carcinoma associated with Castleman's disease and nephrotic syndrome. 38
12413013 2002
32
Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis. 38
11903597 2002
33
Recurrent genetic aberrations in thymoma and thymic carcinoma. 38
10880395 2000
34
A long-term survival case of thymic squamous cell carcinoma, performed complete extirpation with vascular reconstruction of the superior vena cava. 38
10513141 1999
35
Long-term survival of renal transplantation with thymic squamous-cell carcinoma after successful radiation therapy. 38
9838398 1998
36
A thymic squamous cell carcinoma with complex chromosome abnormalities. 38
9595055 1998
37
Thymic carcinoma associated with a high serum level of interleukin 6 diagnosed through the evaluation for asymptomatic elevation of acute-phase reactants. 38
9630206 1998
38
[A case of thymic squamous cell carcinoma successfully treated with curative resection]. 38
8538098 1995
39
[A case of thymic carcinoma successfully controlled by combined chemotherapy and irradiation]. 38
7666619 1995
40
Squamous cell carcinoma of the thymus with paraneoplastic hypercalcemia. 38
7773875 1995
41
[Experience with surgery for metachronous double cancer originated from thymus and lung]. 38
8152186 1994
42
Fine needle aspiration cytology of primary squamous cell carcinoma of the thymus. A case report. 38
8362590 1993
43
Magnetic resonance imaging of thymic squamous cell carcinoma. 38
1446537 1992
44
Thymic carcinoma arising from long standing thymoma and presenting with pituitary metastases. 38
1773413 1991
45
Thymic squamous cell carcinoma. 38
1874658 1991
46
An immunohistochemical study of thymic epithelial tumors. II. Lymphoid component. 38
3789252 1986
47
An immunohistochemical study of thymic epithelial tumors. I. Epithelial component. 38
2420219 1986

Variations for Thymus Squamous Cell Carcinoma

Cosmic variations for Thymus Squamous Cell Carcinoma:

9 (show all 35)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1235014 U2AF1 thymus,NS,thymic carcinoma,squamous cell carcinoma c.467G>A p.R156H 21:43094670-43094670 9
2 COSM11123 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
3 COSM44599 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.587G>A p.R196Q 17:7674944-7674944 9
4 COSM43850 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.659A>C p.Y220S 17:7674872-7674872 9
5 COSM10718 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.524G>T p.R175L 17:7675088-7675088 9
6 COSM44640 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.782+1G>T p.? 17:7674180-7674180 9
7 COSM49007 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.994-1G>T p.? 17:7670716-7670716 9
8 COSM44380 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 9
9 COSM10656 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 9
10 COSM44600 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.598A>G p.N200D 17:7674933-7674933 9
11 COSM14140 SMAD4 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1081C>T p.R361C 18:51065548-51065548 9
12 COSM6191482 SMAD4 thymus,NS,thymic carcinoma,squamous cell carcinoma c.16A>G p.I6V 18:51047062-51047062 9
13 COSM1570338 RET thymus,NS,thymic carcinoma,squamous cell carcinoma c.2651A>T p.E884V 10:43120124-43120124 9
14 COSM6191487 PREX2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.107G>T p.R36L 8:67952501-67952501 9
15 COSM580 NRAS thymus,NS,thymic carcinoma,squamous cell carcinoma c.181C>A p.Q61K 1:114713909-114713909 9
16 COSM6191489 NOTCH2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.3359G>A p.C1120Y 1:119937445-119937445 9
17 COSM520 KRAS thymus,NS,thymic carcinoma,squamous cell carcinoma c.35G>T p.G12V 12:25245350-25245350 9
18 COSM532 KRAS thymus,NS,thymic carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
19 COSM2006821 KMT2D thymus,NS,thymic carcinoma,undifferentiated carcinoma c.11824C>T p.R3942W 12:49032071-49032071 9
20 COSM1304 KIT thymus,NS,thymic carcinoma,squamous cell carcinoma c.1924A>G p.K642E 4:54728055-54728055 9
21 COSM133763 KIT thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1657T>A p.Y553N 4:54727425-54727425 9
22 COSM6191681 KDM6A thymus,NS,thymic carcinoma,squamous cell carcinoma c.3461C>G p.S1154* 23:45085892-45085892 9
23 COSM6191682 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2921C>T p.A974V 23:45078488-45078488 9
24 COSM7002399 JAK2 thymus,NS,thymic carcinoma,squamous cell carcinoma c.2255A>C p.K752T 9:5080352-5080352 9
25 COSM6196604 IL7R thymus,NS,thymic carcinoma,undifferentiated carcinoma c.537+1G>T p.? 5:35871214-35871214 9
26 COSM5031096 HRAS thymus,NS,thymic carcinoma,squamous cell carcinoma c.355G>C p.D119H 11:533548-533548 9
27 COSM6191486 FAT1 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12706A>G p.K4236E 4:186596834-186596834 9
28 COSM88793 EP300 thymus,NS,thymic carcinoma,squamous cell carcinoma c.4617+1G>A p.? 22:41172664-41172664 9
29 COSM5031169 DDR2 thymus,NS,thymic carcinoma,squamous cell carcinoma c.2049-1G>A p.? 1:162776135-162776135 9
30 COSM5095518 CYLD thymus,NS,thymic carcinoma,squamous cell carcinoma c.2305A>T p.I769F 16:50792660-50792660 9
31 COSM5095509 CYLD thymus,NS,thymic carcinoma,squamous cell carcinoma c.2684A>G p.D895G 16:50794426-50794426 9
32 COSM5095514 CYLD thymus,NS,thymic carcinoma,squamous cell carcinoma c.497A>G p.E166G 16:50750195-50750195 9
33 COSM43402 CYLD thymus,NS,thymic carcinoma,squamous cell carcinoma c.1112C>A p.S371* 16:50777915-50777915 9
34 COSM254544 ARID1A thymus,NS,thymic carcinoma,squamous cell carcinoma c.5221C>T p.Q1741* 1:26779119-26779119 9
35 COSM1570337 ALK thymus,NS,thymic carcinoma,squamous cell carcinoma c.3551G>A p.G1184E 2:29220800-29220800 9

Expression for Thymus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Thymus Squamous Cell Carcinoma.

Pathways for Thymus Squamous Cell Carcinoma

GO Terms for Thymus Squamous Cell Carcinoma

Sources for Thymus Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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