MCID: THY027
MIFTS: 25

Thymus Squamous Cell Carcinoma

Categories: Cancer diseases, Immune diseases, Skin diseases

Aliases & Classifications for Thymus Squamous Cell Carcinoma

MalaCards integrated aliases for Thymus Squamous Cell Carcinoma:

Name: Thymus Squamous Cell Carcinoma 12 15
Thymic Squamous Cell Carcinoma 71
Epidermoid Thymic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5530
NCIt 49 C6455
UMLS 71 C1336082

Summaries for Thymus Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the thymus.

MalaCards based summary : Thymus Squamous Cell Carcinoma, also known as thymic squamous cell carcinoma, is related to squamous cell carcinoma, and has symptoms including fatigue, fever and chest pain. An important gene associated with Thymus Squamous Cell Carcinoma is FOXN1 (Forkhead Box N1). Affiliated tissues include thymus, lung and bone.

Related Diseases for Thymus Squamous Cell Carcinoma

Diseases related to Thymus Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.0

Symptoms & Phenotypes for Thymus Squamous Cell Carcinoma

UMLS symptoms related to Thymus Squamous Cell Carcinoma:


fatigue, fever, chest pain, coughing

Drugs & Therapeutics for Thymus Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Thymus Squamous Cell Carcinoma

Genetic Tests for Thymus Squamous Cell Carcinoma

Anatomical Context for Thymus Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Thymus Squamous Cell Carcinoma:

19
Thymus

MalaCards organs/tissues related to Thymus Squamous Cell Carcinoma:

40
Thymus, Lung, Bone, Brain, Skeletal Muscle, Thyroid, Pituitary

Publications for Thymus Squamous Cell Carcinoma

Articles related to Thymus Squamous Cell Carcinoma:

(show all 50)
# Title Authors PMID Year
1
Paratracheal Middle Mediastinal Thymic Carcinomas. 61
31901463 2020
2
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors. 61
31967407 2020
3
A mutational profile in multiple thymic squamous cell carcinoma. 61
32042677 2019
4
A mutation analysis of the EGFR pathway genes, RAS, EGFR, PIK3CA, AKT1 and BRAF, and TP53 gene in thymic carcinoma and thymoma type A/B3. 61
31179560 2019
5
EGFR exon 20 insertion mutation in advanced thymic squamous cell carcinoma: Response to apatinib and clinical outcomes. 61
29740957 2018
6
An immunohistochemical panel consisting of EZH2, C-KIT, and CD205 is useful for distinguishing thymic squamous cell carcinoma from type B3 thymoma. 61
29487009 2018
7
Robot-assisted en bloc anterior mediastinal mass excision with pericardium and adjacent lung for locally advanced thymic carcinoma. 61
29963404 2018
8
Superior vena cava reconstruction under the left internal jugular vein to left femoral vein bypass support. 61
28410562 2017
9
Thymic Carcinoma With Endobronchial Metastasis: A Case Report. 61
28323731 2017
10
PD-L1, PD-1, CD4, and CD8 expression in neoplastic and nonneoplastic thymus. 61
27746267 2017
11
Middle mediastinal thymic carcinoma with cystic findings in radiologic images: a case report. 61
27822875 2016
12
AN INCIDENTAL FINDING OF THYMIC CARCINOMA DURING ELECTIVE CORONARY ARTERY BYPASS GRAFTING. 61
29693844 2016
13
Chemotherapy with gemcitabine plus cisplatin in patients with advanced thymic squamous cell carcinoma: Evaluation of efficacy and toxicity. 61
27042218 2016
14
Development of combined thymic carcinoma and thymoma in an extrathymic lesion during long follow-up for recurrent thymoma. 61
26893849 2016
15
FDG PET/CT Manifestation of Rare Widespread Metastatic Chemoradiation-Refractory Thymic Squamous Cell Carcinoma. 61
26252330 2015
16
The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. 61
26295375 2015
17
Immunohistochemical differentiation between type B3 thymomas and thymic squamous cell carcinomas. 61
26191237 2015
18
Two Cases of Thymic Carcinoma Initially Presenting as Bone Metastasis: A Clinical Report and the Usefulness of CD5 Immunohistochemistry for Assessing Bone Lesions. 61
26179536 2015
19
Genetic profiling of thymic carcinoma using targeted next-generation sequencing. 61
25249426 2014
20
[Clinical analysis of 11 cases of thymic squamous cell carcinoma]. 61
25030597 2014
21
[A case of postoperative thymic carcinoma recurrence that was effectively treated with combination chemotherapy of nedaplatin and docetaxel]. 61
24335370 2013
22
Analysis of MAML2 rearrangement in mucoepidermoid carcinoma of the thymus. 61
24134933 2013
23
Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases. 61
23866799 2013
24
Identification of novel mutations of TP53, ALK and RET gene in metastatic thymic squamous cell carcinoma and its therapeutic implication. 61
23639785 2013
25
Absence of gene mutations in KIT-positive carcinoma showing thymus-like elements of the thyroid. 61
21835435 2012
26
Erythrocytosis caused by erythropoietin-producing thymic carcinoma. 61
20179983 2010
27
Thymic squamous cell carcinoma with multiple brain metastases. 61
20714951 2010
28
Thymic squamous cell carcinoma producing granulocyte colony-stimulating factor associated with a high serum level of interleukin 6. 61
19967491 2009
29
Spontaneous mediastinal haemorrhage linked with thymic carcinoma and myelodysplasia: a case report. 61
19830017 2009
30
Multiple inflammatory cytokine-productive ThyL-6 cell line established from a patient with thymic carcinoma. 61
18691242 2008
31
Novel prognostic groups in thymic epithelial tumors: assessment of risk and therapeutic strategy selection. 61
18164843 2008
32
Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma. 61
17120029 2007
33
Thymic squamous cell carcinoma producing parathyroid hormone-related protein and CYFRA 21-1. 61
15283186 2004
34
Interleukin-6-producing thymic squamous cell carcinoma associated with Castleman's disease and nephrotic syndrome. 61
12413013 2002
35
Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis. 61
11903597 2002
36
Recurrent genetic aberrations in thymoma and thymic carcinoma. 61
10880395 2000
37
A long-term survival case of thymic squamous cell carcinoma, performed complete extirpation with vascular reconstruction of the superior vena cava. 61
10513141 1999
38
Long-term survival of renal transplantation with thymic squamous-cell carcinoma after successful radiation therapy. 61
9838398 1998
39
A thymic squamous cell carcinoma with complex chromosome abnormalities. 61
9595055 1998
40
Thymic carcinoma associated with a high serum level of interleukin 6 diagnosed through the evaluation for asymptomatic elevation of acute-phase reactants. 61
9630206 1998
41
[A case of thymic squamous cell carcinoma successfully treated with curative resection]. 61
8538098 1995
42
[A case of thymic carcinoma successfully controlled by combined chemotherapy and irradiation]. 61
7666619 1995
43
Squamous cell carcinoma of the thymus with paraneoplastic hypercalcemia. 61
7773875 1995
44
[Experience with surgery for metachronous double cancer originated from thymus and lung]. 61
8152186 1994
45
Fine needle aspiration cytology of primary squamous cell carcinoma of the thymus. A case report. 61
8362590 1993
46
Magnetic resonance imaging of thymic squamous cell carcinoma. 61
1446537 1992
47
Thymic carcinoma arising from long standing thymoma and presenting with pituitary metastases. 61
1773413 1991
48
Thymic squamous cell carcinoma. 61
1874658 1991
49
An immunohistochemical study of thymic epithelial tumors. II. Lymphoid component. 61
3789252 1986
50
An immunohistochemical study of thymic epithelial tumors. I. Epithelial component. 61
2420219 1986

Variations for Thymus Squamous Cell Carcinoma

Cosmic variations for Thymus Squamous Cell Carcinoma:

9 (show top 50) (show all 260)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM85194352 U2AF1 thymus,NS,thymic carcinoma,squamous cell carcinoma c.467G>A p.R156H 21:43094670-43094670 9
2 COSM87940839 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.994-1G>T p.? 17:7670716-7670716 9
3 COSM87899067 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 9
4 COSM87975416 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 9
5 COSM87905284 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.587G>A p.R196Q 17:7674944-7674944 9
6 COSM87933590 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.524G>T p.R175L 17:7675088-7675088 9
7 COSM87904722 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.782+1G>T p.? 17:7674180-7674180 9
8 COSM87912399 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.598A>G p.N200D 17:7674933-7674933 9
9 COSM87906659 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.659A>C p.Y220S 17:7674872-7674872 9
10 COSM87898709 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 9
11 COSM91380576 SMAD4 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1081C>T p.R361C 18:51065548-51065548 9
12 COSM91391748 SMAD4 thymus,NS,thymic carcinoma,squamous cell carcinoma c.16A>G p.I6V 18:51047062-51047062 9
13 COSM103041184 SETD2 thymus,NS,thymic carcinoma,squamous cell carcinoma c.4578G>T p.M1526I 3:47116631-47116631 9
14 COSM92347951 RET thymus,NS,thymic carcinoma,squamous cell carcinoma c.2651A>T p.E884V 10:43120124-43120124 9
15 COSM88596522 PREX2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.107G>T p.R36L 8:67952501-67952501 9
16 COSM97107326 NRAS thymus,NS,thymic carcinoma,squamous cell carcinoma c.181C>A p.Q61K 1:114713909-114713909 9
17 COSM88408638 NOTCH2 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.3359G>A p.C1120Y 1:119937445-119937445 9
18 COSM87804028 KRAS thymus,NS,thymic carcinoma,squamous cell carcinoma c.38G>A p.G13D 12:25245347-25245347 9
19 COSM87804055 KRAS thymus,NS,thymic carcinoma,squamous cell carcinoma c.35G>T p.G12V 12:25245350-25245350 9
20 COSM87667907 KMT2D thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12634C>T p.R4212W 12:49032071-49032071 9
21 COSM88313315 KIT thymus,NS,thymic carcinoma,squamous cell carcinoma c.1924A>G p.K642E 4:54728055-54728055 9
22 COSM88314740 KIT thymus,NS,thymic carcinoma,undifferentiated carcinoma c.1657T>A p.Y553N 4:54727425-54727425 9
23 COSM102171788 KDM6A thymus,NS,thymic carcinoma,squamous cell carcinoma c.3461C>G p.S1154* 23:45085892-45085892 9
24 COSM102181889 KDM6A thymus,NS,thymic carcinoma,undifferentiated carcinoma c.2921C>T p.A974V 23:45078488-45078488 9
25 COSM98731834 JAK2 thymus,NS,thymic carcinoma,squamous cell carcinoma c.2255A>C p.K752T 9:5080352-5080352 9
26 COSM85170206 IL7R thymus,NS,thymic carcinoma,undifferentiated carcinoma c.537+1G>T p.? 5:35871214-35871214 9
27 COSM112999429 HRAS thymus,NS,thymic carcinoma,squamous cell carcinoma c.355G>C p.D119H 11:533548-533548 9
28 COSM110448949 FAT1 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.12706A>G p.K4236E 4:186596834-186596834 9
29 COSM85964440 EP300 thymus,NS,thymic carcinoma,squamous cell carcinoma c.4617+1G>A p.? 22:41172664-41172664 9
30 COSM95997479 DDR2 thymus,NS,thymic carcinoma,squamous cell carcinoma c.2049-1G>A p.? 1:162776135-162776135 9
31 COSM110981267 CYLD thymus,NS,thymic carcinoma,squamous cell carcinoma c.2305A>T p.I769F 16:50792660-50792660 9
32 COSM110983365 CYLD thymus,NS,thymic carcinoma,squamous cell carcinoma c.2684A>G p.D895G 16:50794426-50794426 9
33 COSM110983357 CYLD thymus,NS,thymic carcinoma,squamous cell carcinoma c.497A>G p.E166G 16:50750195-50750195 9
34 COSM110982684 CYLD thymus,NS,thymic carcinoma,squamous cell carcinoma c.1112C>A p.S371* 16:50777915-50777915 9
35 COSM89203898 ARID1A thymus,NS,thymic carcinoma,squamous cell carcinoma c.5221C>T p.Q1741* 1:26779119-26779119 9
36 COSM99413113 ALK thymus,NS,thymic carcinoma,squamous cell carcinoma c.3551G>A p.G1184E 2:29220800-29220800 9
37 COSM106058929 thymus,NS,thymic carcinoma,squamous cell carcinoma c.587G>A p.R196Q 17:7674944-7674944 9
38 COSM111771838 thymus,NS,thymic carcinoma,squamous cell carcinoma c.598A>G p.N200D 17:7674933-7674933 9
39 COSM108818226 thymus,NS,thymic carcinoma,squamous cell carcinoma c.4069C>T p.Q1357* 1:26779119-26779119 9
40 COSM103457588 thymus,NS,thymic carcinoma,squamous cell carcinoma c.497A>G p.E166G 16:50750195-50750195 9
41 COSM105695698 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 9
42 COSM121876918 thymus,NS,thymic carcinoma,squamous cell carcinoma c.442A>G p.R148G 17:7673782-7673782 9
43 COSM144019306 thymus,NS,thymic carcinoma,squamous cell carcinoma c.554G>A p.R185Q 17:7674944-7674944 9
44 COSM135823006 thymus,NS,thymic carcinoma,squamous cell carcinoma c.2675A>G p.D892G 16:50794426-50794426 9
45 COSM149732181 thymus,NS,thymic carcinoma,squamous cell carcinoma c.347G>A p.G116E 2:29220800-29220800 9
46 COSM111788646 thymus,NS,thymic carcinoma,squamous cell carcinoma c.524G>T p.R175L 17:7675088-7675088 9
47 COSM142859154 thymus,NS,thymic carcinoma,squamous cell carcinoma c.524G>T p.R175L 17:7675088-7675088 9
48 COSM142565464 thymus,NS,thymic carcinoma,squamous cell carcinoma c.665+1G>T p.? 17:7674180-7674180 9
49 COSM121915321 thymus,NS,thymic carcinoma,squamous cell carcinoma c.*101-1G>T p.? 17:7670716-7670716 9
50 COSM144651436 thymus,NS,thymic carcinoma,squamous cell carcinoma c.625C>T p.R209W 17:7674221-7674221 9

Expression for Thymus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Thymus Squamous Cell Carcinoma.

Pathways for Thymus Squamous Cell Carcinoma

GO Terms for Thymus Squamous Cell Carcinoma

Sources for Thymus Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
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35 IUPHAR
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39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
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50 NDF-RT
53 NINDS
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56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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