MCID: THY027
MIFTS: 24

Thymus Squamous Cell Carcinoma

Categories: Cancer diseases, Immune diseases, Skin diseases

Aliases & Classifications for Thymus Squamous Cell Carcinoma

MalaCards integrated aliases for Thymus Squamous Cell Carcinoma:

Name: Thymus Squamous Cell Carcinoma 12 15
Thymic Squamous Cell Carcinoma 70
Epidermoid Thymic Carcinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5530
NCIt 50 C6455
UMLS 70 C1336082

Summaries for Thymus Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the thymus.

MalaCards based summary : Thymus Squamous Cell Carcinoma, is also known as thymic squamous cell carcinoma, and has symptoms including fatigue, fever and chest pain. An important gene associated with Thymus Squamous Cell Carcinoma is FOXN1 (Forkhead Box N1). Affiliated tissues include thymus, bone and skeletal muscle.

Related Diseases for Thymus Squamous Cell Carcinoma

Symptoms & Phenotypes for Thymus Squamous Cell Carcinoma

UMLS symptoms related to Thymus Squamous Cell Carcinoma:


fatigue; fever; chest pain; coughing

Drugs & Therapeutics for Thymus Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Thymus Squamous Cell Carcinoma

Genetic Tests for Thymus Squamous Cell Carcinoma

Anatomical Context for Thymus Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Thymus Squamous Cell Carcinoma:

19
Thymus

MalaCards organs/tissues related to Thymus Squamous Cell Carcinoma:

40
Thymus, Bone, Skeletal Muscle, Small Intestine, Pituitary

Publications for Thymus Squamous Cell Carcinoma

Articles related to Thymus Squamous Cell Carcinoma:

(show top 50) (show all 59)
# Title Authors PMID Year
1
Mutation Profile of Thymic Carcinoma and Thymic Neuroendocrine Tumor by Targeted Next-generation Sequencing. 61
33414055 2021
2
SS-A52 antigen expression in thymic carcinoma accompanied with Sjögren syndrome: A case report. 61
33592902 2021
3
A Tuft Cell-Like Signature Is Highly Prevalent in Thymic Squamous Cell Carcinoma and Delineates New Molecular Subsets Among the Major Lung Cancer Histotypes. 61
33609752 2021
4
Durable efficacy of anlotinib in a patient with advanced thymic squamous cell carcinoma after multiline chemotherapy and apatinib: A case report and literature review. 61
32997432 2020
5
Thymic carcinoma metastasize to the small intestine: a case report. 61
33115438 2020
6
A Rare Case of a High-Grade Thymic Squamous Cell Carcinoma Presenting as Cardiac Tamponade. 61
32850235 2020
7
Preferentially expressed antigen in melanoma as a novel diagnostic marker differentiating thymic squamous cell carcinoma from thymoma. 61
32704057 2020
8
Paratracheal Middle Mediastinal Thymic Carcinomas. 61
31901463 2020
9
Deciphering tissue-based proteome signatures revealed novel subtyping and prognostic markers for thymic epithelial tumors. 61
31967407 2020
10
The Effect and Safety of Anti-PD-1 Single/Combination Therapy in Refractory Thymic Carcinoma: A Case-Series Study. 61
33192094 2020
11
Thymic Squamous Cell Carcinoma: A Population-Based Surveillance, Epidemiology, and End Result Analysis. 61
33415074 2020
12
A mutational profile in multiple thymic squamous cell carcinoma. 61
32042677 2019
13
A mutation analysis of the EGFR pathway genes, RAS, EGFR, PIK3CA, AKT1 and BRAF, and TP53 gene in thymic carcinoma and thymoma type A/B3. 61
31179560 2019
14
EGFR exon 20 insertion mutation in advanced thymic squamous cell carcinoma: Response to apatinib and clinical outcomes. 61
29740957 2018
15
An immunohistochemical panel consisting of EZH2, C-KIT, and CD205 is useful for distinguishing thymic squamous cell carcinoma from type B3 thymoma. 61
29487009 2018
16
Robot-assisted en bloc anterior mediastinal mass excision with pericardium and adjacent lung for locally advanced thymic carcinoma. 61
29963404 2018
17
Superior vena cava reconstruction under the left internal jugular vein to left femoral vein bypass support. 61
28410562 2017
18
Thymic Carcinoma With Endobronchial Metastasis: A Case Report. 61
28323731 2017
19
PD-L1, PD-1, CD4, and CD8 expression in neoplastic and nonneoplastic thymus. 61
27746267 2017
20
Middle mediastinal thymic carcinoma with cystic findings in radiologic images: a case report. 61
27822875 2016
21
AN INCIDENTAL FINDING OF THYMIC CARCINOMA DURING ELECTIVE CORONARY ARTERY BYPASS GRAFTING. 61
29693844 2016
22
Chemotherapy with gemcitabine plus cisplatin in patients with advanced thymic squamous cell carcinoma: Evaluation of efficacy and toxicity. 61
27042218 2016
23
Development of combined thymic carcinoma and thymoma in an extrathymic lesion during long follow-up for recurrent thymoma. 61
26893849 2016
24
FDG PET/CT Manifestation of Rare Widespread Metastatic Chemoradiation-Refractory Thymic Squamous Cell Carcinoma. 61
26252330 2015
25
The 2015 World Health Organization Classification of Tumors of the Thymus: Continuity and Changes. 61
26295375 2015
26
Two Cases of Thymic Carcinoma Initially Presenting as Bone Metastasis: A Clinical Report and the Usefulness of CD5 Immunohistochemistry for Assessing Bone Lesions. 61
26179536 2015
27
Immunohistochemical differentiation between type B3 thymomas and thymic squamous cell carcinomas. 61
26191237 2015
28
Genetic profiling of thymic carcinoma using targeted next-generation sequencing. 61
25249426 2014
29
[Clinical analysis of 11 cases of thymic squamous cell carcinoma]. 61
25030597 2014
30
[A case of postoperative thymic carcinoma recurrence that was effectively treated with combination chemotherapy of nedaplatin and docetaxel]. 61
24335370 2013
31
Analysis of MAML2 rearrangement in mucoepidermoid carcinoma of the thymus. 61
24134933 2013
32
Surgical treatment and prognosis of thymic squamous cell carcinoma: a retrospective analysis of 105 cases. 61
23866799 2013
33
Identification of novel mutations of TP53, ALK and RET gene in metastatic thymic squamous cell carcinoma and its therapeutic implication. 61
23639785 2013
34
Absence of gene mutations in KIT-positive carcinoma showing thymus-like elements of the thyroid. 61
21835435 2012
35
Erythrocytosis caused by erythropoietin-producing thymic carcinoma. 61
20179983 2010
36
Thymic squamous cell carcinoma with multiple brain metastases. 61
20714951 2010
37
Thymic squamous cell carcinoma producing granulocyte colony-stimulating factor associated with a high serum level of interleukin 6. 61
19967491 2009
38
Spontaneous mediastinal haemorrhage linked with thymic carcinoma and myelodysplasia: a case report. 61
19830017 2009
39
Multiple inflammatory cytokine-productive ThyL-6 cell line established from a patient with thymic carcinoma. 61
18691242 2008
40
Novel prognostic groups in thymic epithelial tumors: assessment of risk and therapeutic strategy selection. 61
18164843 2008
41
Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma. 61
17120029 2007
42
Thymic squamous cell carcinoma producing parathyroid hormone-related protein and CYFRA 21-1. 61
15283186 2004
43
Interleukin-6-producing thymic squamous cell carcinoma associated with Castleman's disease and nephrotic syndrome. 61
12413013 2002
44
Thymic sarcomatoid carcinoma with skeletal muscle differentiation: report of two cases, one with cytogenetic analysis. 61
11903597 2002
45
Recurrent genetic aberrations in thymoma and thymic carcinoma. 61
10880395 2000
46
A long-term survival case of thymic squamous cell carcinoma, performed complete extirpation with vascular reconstruction of the superior vena cava. 61
10513141 1999
47
Long-term survival of renal transplantation with thymic squamous-cell carcinoma after successful radiation therapy. 61
9838398 1998
48
A thymic squamous cell carcinoma with complex chromosome abnormalities. 61
9595055 1998
49
Thymic carcinoma associated with a high serum level of interleukin 6 diagnosed through the evaluation for asymptomatic elevation of acute-phase reactants. 61
9630206 1998
50
[A case of thymic squamous cell carcinoma successfully treated with curative resection]. 61
8538098 1995

Variations for Thymus Squamous Cell Carcinoma

Cosmic variations for Thymus Squamous Cell Carcinoma:

9 (show top 50) (show all 260)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM112018564 U2AF1 thymus,NS,thymic carcinoma,squamous cell carcinoma c.248G>A p.R83H 21:43094670-43094670 6
2 COSM102446190 U2AF1 thymus,NS,thymic carcinoma,squamous cell carcinoma c.248G>A p.R83H 21:43094670-43094670 6
3 COSM99369103 U2AF1 thymus,NS,thymic carcinoma,squamous cell carcinoma c.467G>A p.R156H 21:43094670-43094670 6
4 COSM85194352 U2AF1 thymus,NS,thymic carcinoma,squamous cell carcinoma c.467G>A p.R156H 21:43094670-43094670 6
5 COSM106058929 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.587G>A p.R196Q 17:7674944-7674944 6
6 COSM111771838 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.598A>G p.N200D 17:7674933-7674933 6
7 COSM87940839 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.994-1G>T p.? 17:7670716-7670716 6
8 COSM105695698 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 6
9 COSM121876918 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.442A>G p.R148G 17:7673782-7673782 6
10 COSM144019306 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.554G>A p.R185Q 17:7674944-7674944 6
11 COSM111788646 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.524G>T p.R175L 17:7675088-7675088 6
12 COSM142859154 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.524G>T p.R175L 17:7675088-7675088 6
13 COSM142565464 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.665+1G>T p.? 17:7674180-7674180 6
14 COSM121915321 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.*101-1G>T p.? 17:7670716-7670716 6
15 COSM144651436 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.625C>T p.R209W 17:7674221-7674221 6
16 COSM142837846 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 6
17 COSM144310429 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.625C>T p.R209W 17:7674221-7674221 6
18 COSM122734399 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.346C>T p.R116W 17:7674221-7674221 6
19 COSM93213412 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.524G>T p.R175L 17:7675088-7675088 6
20 COSM106065142 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.598A>G p.N200D 17:7674933-7674933 6
21 COSM105626785 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.587G>A p.R196Q 17:7674944-7674944 6
22 COSM144688312 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.*101-1G>T p.? 17:7670716-7670716 6
23 COSM122300550 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.128G>T p.R43L 17:7675088-7675088 6
24 COSM142891951 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 6
25 COSM144091146 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.110G>A p.R37Q 17:7674944-7674944 6
26 COSM144109717 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.47G>T p.R16L 17:7675088-7675088 6
27 COSM143161712 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.110G>A p.R37Q 17:7674944-7674944 6
28 COSM87899067 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 6
29 COSM144333110 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.407G>T p.R136L 17:7675088-7675088 6
30 COSM87975416 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 6
31 COSM144659339 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.542A>C p.Y181S 17:7674872-7674872 6
32 COSM144657270 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.665+1G>T p.? 17:7674180-7674180 6
33 COSM145029517 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.481A>G p.N161D 17:7674933-7674933 6
34 COSM122307188 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.598-1G>T p.? 17:7670716-7670716 6
35 COSM144319822 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.481A>G p.N161D 17:7674933-7674933 6
36 COSM112260279 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.659A>C p.Y220S 17:7674872-7674872 6
37 COSM122739428 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.386+1G>T p.? 17:7674180-7674180 6
38 COSM143944515 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.361A>G p.R121G 17:7673782-7673782 6
39 COSM122277286 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.191G>A p.R64Q 17:7674944-7674944 6
40 COSM111758868 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 6
41 COSM142627127 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.259T>A p.Y87N 17:7675236-7675236 6
42 COSM143376843 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.470G>A p.R157Q 17:7674944-7674944 6
43 COSM112254260 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.838A>G p.R280G 17:7673782-7673782 6
44 COSM143977374 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.*13-1G>T p.? 17:7670716-7670716 6
45 COSM121944830 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.-21T>A p.? 17:7675236-7675236 6
46 COSM121908505 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.128G>T p.R43L 17:7675088-7675088 6
47 COSM106116533 TP53 thymus,NS,thymic carcinoma,undifferentiated carcinoma c.376T>A p.Y126N 17:7675236-7675236 6
48 COSM93191127 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.659A>C p.Y220S 17:7674872-7674872 6
49 COSM142841613 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.782+1G>T p.? 17:7674180-7674180 6
50 COSM144114638 TP53 thymus,NS,thymic carcinoma,squamous cell carcinoma c.517-1G>T p.? 17:7670716-7670716 6

Expression for Thymus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Thymus Squamous Cell Carcinoma.

Pathways for Thymus Squamous Cell Carcinoma

GO Terms for Thymus Squamous Cell Carcinoma

Sources for Thymus Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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