MCID: THY004
MIFTS: 26

Thyroid Angiosarcoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Thyroid Angiosarcoma

MalaCards integrated aliases for Thyroid Angiosarcoma:

Name: Thyroid Angiosarcoma 12 15 72
Hemangiosarcoma of the Thyroid 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4514
NCIt 50 C6043
UMLS 72 C1336748

Summaries for Thyroid Angiosarcoma

Disease Ontology : 12 A thyroid sarcoma and angiosarcoma that results in a high prevalence of iodine-deficient goiter.

MalaCards based summary : Thyroid Angiosarcoma, also known as hemangiosarcoma of the thyroid, is related to angiosarcoma and thyroiditis. An important gene associated with Thyroid Angiosarcoma is PECAM1 (Platelet And Endothelial Cell Adhesion Molecule 1), and among its related pathways/superpathways is Lung fibrosis. Affiliated tissues include thyroid, bone and small intestine, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Thyroid Angiosarcoma

Diseases related to Thyroid Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 31.0 VWF PECAM1
2 thyroiditis 29.8 TG CALCA
3 multinodular goiter 29.5 TG PAX8 CALCA
4 goiter 29.5 TG PAX8 CALCA
5 water-clear cell adenoma 10.4 TG PAX8
6 athyreosis 10.4 TG PAX8
7 hypothyroidism, congenital, nongoitrous, 2 10.4 TG PAX8
8 erythema elevatum diutinum 10.3 PECAM1 CD34
9 pericardium cancer 10.3 THBD FOXK1
10 rete testis neoplasm 10.3 THBD PAX8
11 pericardial mesothelioma 10.3 THBD FOXK1
12 sclerosing liposarcoma 10.3 PAX8 CD34
13 spermatocele 10.3 TG TERT
14 exophthalmos 10.2 TG CD34
15 senile angioma 10.2 THBD CD34
16 ovarian brenner tumor 10.2 THBD PAX8
17 nephrogenic adenofibroma 10.2 PAX8 CD34
18 unilateral absence of a pulmonary artery 10.1 VWF THBD
19 pendred syndrome 10.1 TG PAX8
20 cystitis cystica 10.1 THBD TERT
21 cellular schwannoma 10.1 PAX8 CD34
22 raynaud phenomenon 10.1 VWF THBD
23 spleen angiosarcoma 10.1 VWF CD34
24 eisenmenger syndrome 10.1 VWF THBD
25 grange syndrome 10.1 VWF THBD
26 deep angioma 10.1 VWF CD34
27 cell type benign neoplasm 10.1 TG CD34
28 intramuscular hemangioma 10.0 VWF CD34
29 nodular goiter 10.0 TG CALCA
30 spotted fever 10.0 VWF THBD
31 suppurative thyroiditis 10.0 TG CALCA
32 atypical follicular adenoma 10.0 TG CALCA
33 acute thyroiditis 10.0 TG CALCA
34 hypoadrenalism 10.0 TG CALCA
35 diabetic angiopathy 10.0 VWF THBD
36 liver angiosarcoma 10.0 VWF CD34
37 fetal adenoma 10.0 TG CALCA
38 amyloid tumor 10.0 TG CALCA
39 nontoxic goiter 10.0 TG CALCA
40 ovarian cystic teratoma 10.0 TG CALCA
41 papillary thyroid microcarcinoma 10.0 TG CALCA
42 blood coagulation disease 9.9 VWF THBD
43 thyroid tumor 9.9
44 lymphangiosarcoma 9.9 VWF CD34
45 thrombophilia due to activated protein c resistance 9.9 VWF THBD
46 thrombotic thrombocytopenic purpura 9.9 VWF THBD
47 vascular cancer 9.9 VWF CD34
48 hashimoto thyroiditis 9.8
49 autoimmune lymphoproliferative syndrome 9.8
50 thyroid gland anaplastic carcinoma 9.8

Graphical network of the top 20 diseases related to Thyroid Angiosarcoma:



Diseases related to Thyroid Angiosarcoma

Symptoms & Phenotypes for Thyroid Angiosarcoma

MGI Mouse Phenotypes related to Thyroid Angiosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.7 CD34 FOXK1 PAX8 PECAM1 TERT THBD
2 digestive/alimentary MP:0005381 9.35 PECAM1 TERT TG THBD VWF
3 homeostasis/metabolism MP:0005376 9.17 CD34 PAX8 PECAM1 TERT TG THBD

Drugs & Therapeutics for Thyroid Angiosarcoma

Search Clinical Trials , NIH Clinical Center for Thyroid Angiosarcoma

Genetic Tests for Thyroid Angiosarcoma

Anatomical Context for Thyroid Angiosarcoma

MalaCards organs/tissues related to Thyroid Angiosarcoma:

41
Thyroid, Bone, Small Intestine, Bone Marrow

Publications for Thyroid Angiosarcoma

Articles related to Thyroid Angiosarcoma:

(show all 21)
# Title Authors PMID Year
1
Corrigendum to 'Primary thyroid angiosarcoma: A systematic review' [Oral Oncol. 82 (2018) 48-52]. 38
30824286 2019
2
Primary thyroid angiosarcoma: A systematic review. 38
29909901 2018
3
Primary diagnosis of angiosarcoma by fine needle aspiration: Lessons learned from 3 cases. 38
29087044 2018
4
Angioinvasion as a factor for predicting aggressive outcome in primary thyroid angiosarcoma: three case reports and literature review. 38
29895127 2018
5
Rapidly Growing Vascular Mass Within the Thyroid. Angiosarcoma. 38
26868891 2016
6
An extremely rare case of thyroid malignancy from the non-Alpine region: Angiosarcoma. 38
26741273 2016
7
Primary Thyroid Angiosarcoma with Tracheal Invasion. 38
27150873 2016
8
Electron microscopic analysis of an angiosarcoma of the thyroid from a non-Alpine endemic goiter region: A case report and brief review of the literature. 38
25289092 2014
9
Invasive thyroid angiosarcoma with a favorable outcome. 38
25745482 2014
10
[Intestinal bleeding and obstruction in the small intestine caused by metastatic thyroid angiosarcoma. Case report]. 38
24880971 2014
11
Thyroid nodule. Primary thyroid angiosarcoma. 38
24652086 2014
12
Non-Alpine thyroid angiosarcoma. 38
23570682 2013
13
Nonalpine thyroid angiosarcoma in a patient with hashimoto thyroiditis. 38
24349811 2013
14
Primary thyroid angiosarcoma: an unusual localization. 38
22553943 2012
15
Gemcitabine in advanced angiosarcoma: a retrospective case series analysis from the Italian Rare Cancer Network. 38
21464156 2012
16
Angiosarcoma of the thyroid. 38
18941766 2009
17
A case of hemangiosarcoma in thyroid with severe anemia due to bone marrow metastasis. 38
15758558 2005
18
[Epithelioid hemangiosarcoma of the thyroid gland]. 38
12061199 2002
19
Hemangiosarcoma of the Thyroid Gland. A case report. 38
11455353 2000
20
[Primary thyroid angiosarcoma]. 38
8234992 1993
21
Hemangiosarcoma of the thyroid gland. Histological diagnosis problems. 38
6199664 1983

Variations for Thyroid Angiosarcoma

Expression for Thyroid Angiosarcoma

Search GEO for disease gene expression data for Thyroid Angiosarcoma.

Pathways for Thyroid Angiosarcoma

Pathways related to Thyroid Angiosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.42 TERT CALCA

GO Terms for Thyroid Angiosarcoma

Cellular components related to Thyroid Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 PECAM1 CD34

Biological processes related to Thyroid Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood pressure GO:0008217 9.4 CD34 CALCA
2 hemostasis GO:0007599 9.37 VWF THBD
3 endothelial cell migration GO:0043542 9.32 PECAM1 CALCA
4 leukocyte cell-cell adhesion GO:0007159 9.26 PECAM1 CALCA
5 thyroid gland development GO:0030878 9.16 TG PAX8
6 negative regulation of blood coagulation GO:0030195 8.96 THBD CD34
7 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Sources for Thyroid Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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