NMTC3
MCID: THY117
MIFTS: 16

Thyroid Cancer, Nonmedullary, 3 (NMTC3)

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Thyroid Cancer, Nonmedullary, 3

MalaCards integrated aliases for Thyroid Cancer, Nonmedullary, 3:

Name: Thyroid Cancer, Nonmedullary, 3 56
Thyroid Cancer, Nonmedullary, 1, Formerly; Nmtc1, Formerly 56
Thyroid Cancer, Nonmedullary, 1, Formerly 56
Thyroid Carcinoma, Nonmedullary, 3 56
Nmtc1, Formerly 56
Nmtc3 56

Characteristics:

OMIM:

56
Inheritance:
autosomal dominant


HPO:

31
thyroid cancer, nonmedullary, 3:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 56 606240
OMIM Phenotypic Series 56 PS188550
MedGen 41 C4225410
SNOMED-CT via HPO 68 263681008

Summaries for Thyroid Cancer, Nonmedullary, 3

OMIM : 56 Nonmedullary thyroid cancer (NMTC) comprises thyroid cancers of follicular cell origin and accounts for more than 95% of all thyroid cancer cases. The remaining cancers originate from parafollicular cells (medullary thyroid cancer, MTC; 155240). NMTC is classified into 4 groups: papillary, follicular, Hurthle cell (607464), and anaplastic. Approximately 5% of NMTC is hereditary, occurring as a minor component of a familial cancer syndrome (e.g., familial adenomatous polyposis 175100, Carney complex 160980) or as a primary feature (familial NMTC or FNMTC). Papillary thyroid cancer (PTC) is the most common histologic subtype of FNMTC, accounting for approximately 85% of cases (summary by Vriens et al., 2009). For a general phenotypic description and a discussion of genetic heterogeneity of NMTC, see NMTC1 (188550). (606240)

MalaCards based summary : Thyroid Cancer, Nonmedullary, 3, also known as thyroid cancer, nonmedullary, 1, formerly; nmtc1, formerly, is related to thyroid carcinoma and familial nonmedullary thyroid carcinoma. An important gene associated with Thyroid Cancer, Nonmedullary, 3 is NMTC3 (Nonmedullary Thyroid Carcinoma 3). Affiliated tissues include thyroid, and related phenotype is non-medullary thyroid carcinoma.

Related Diseases for Thyroid Cancer, Nonmedullary, 3

Diseases in the Familial Nonmedullary Thyroid Carcinoma family:

Thyroid Cancer, Nonmedullary, 2 Thyroid Cancer, Nonmedullary, 1
Thyroid Cancer, Nonmedullary, 3 Thyroid Cancer, Nonmedullary, 4
Thyroid Cancer, Nonmedullary, 5

Diseases related to Thyroid Cancer, Nonmedullary, 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 2, show less)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma 11.4
2 familial nonmedullary thyroid carcinoma 11.2

Symptoms & Phenotypes for Thyroid Cancer, Nonmedullary, 3

Human phenotypes related to Thyroid Cancer, Nonmedullary, 3:

31 (showing 1, show less)
# Description HPO Frequency HPO Source Accession
1 non-medullary thyroid carcinoma 31 HP:0040198

Symptoms via clinical synopsis from OMIM:

56
Neoplasia:
nonmedullary thyroid carcinoma (follicular)

Clinical features from OMIM:

606240

Drugs & Therapeutics for Thyroid Cancer, Nonmedullary, 3

Search Clinical Trials , NIH Clinical Center for Thyroid Cancer, Nonmedullary, 3

Genetic Tests for Thyroid Cancer, Nonmedullary, 3

Anatomical Context for Thyroid Cancer, Nonmedullary, 3

MalaCards organs/tissues related to Thyroid Cancer, Nonmedullary, 3:

40
Thyroid

Publications for Thyroid Cancer, Nonmedullary, 3

Articles related to Thyroid Cancer, Nonmedullary, 3:

(showing 4, show less)
# Title Authors PMID Year
1
Clinical features and genetic predisposition to hereditary nonmedullary thyroid cancer. 56
20001717 2009
2
Localization of a susceptibility gene for familial nonmedullary thyroid carcinoma to chromosome 2q21. 56
11438887 2001
3
At least three genes account for familial papillary thyroid carcinoma: TCO and MNG1 excluded as susceptibility loci from a large Tasmanian family. 56
10427154 1999
4
Two families with an autosomal dominant inheritance pattern for papillary carcinoma of the thyroid. 56
9024215 1997

Variations for Thyroid Cancer, Nonmedullary, 3

Expression for Thyroid Cancer, Nonmedullary, 3

Search GEO for disease gene expression data for Thyroid Cancer, Nonmedullary, 3.

Pathways for Thyroid Cancer, Nonmedullary, 3

GO Terms for Thyroid Cancer, Nonmedullary, 3

Sources for Thyroid Cancer, Nonmedullary, 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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