HCTC
MCID: THY096
MIFTS: 24

Thyroid Carcinoma, Hurthle Cell (HCTC)

Categories: Cancer diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Thyroid Carcinoma, Hurthle Cell

MalaCards integrated aliases for Thyroid Carcinoma, Hurthle Cell:

Name: Thyroid Carcinoma, Hurthle Cell 57 20 13 54
Hurthle Cell Carcinoma of Thyroid 29 6 39
Hurthle Cell Thyroid Neoplasia 57 72
Thyroid Cancer, Follicular, Hurthle Cell Type 20
Follicular Thyroid Cancer, Hurthle Cell Type 20
Hurthle Cell Carcinoma of the Thyroid 20
Hurthle Cell Thyroid Carcinoma 72
Thyroid Hurthle Cell Carcinoma 70
Thyroid Cancer, Hurthle Cell 20
Hurthle Cell Thyroid Cancer 20
Adenocarcinoma, Oxyphilic 70
Hurthle Cell Carcinoma 72
Hctc 72

Classifications:



External Ids:

OMIM® 57 607464
MeSH 44 D013964
MedGen 41 C0749424
UMLS 70 C0205642 C0749424

Summaries for Thyroid Carcinoma, Hurthle Cell

OMIM® : 57 Hurthle cell carcinoma of the thyroid accounts for approximately 3% of all thyroid cancers. Although they are classified as variants of follicular neoplasms, they are more often multifocal and somewhat more aggressive and are less likely to take up iodine than are other follicular neoplasms (Sanders and Silverman, 1998). Hurthle cell tumors, also known as oxyphil cell tumors, are composed of cells with increased numbers of mitochondria, which corresponds morphologically to their voluminous, granular, eosinophilic cytoplasm (Maximo et al., 2005). (607464) (Updated 20-May-2021)

MalaCards based summary : Thyroid Carcinoma, Hurthle Cell, also known as hurthle cell carcinoma of thyroid, is related to thyroid gland hurthle cell carcinoma and lipomatosis, multiple. An important gene associated with Thyroid Carcinoma, Hurthle Cell is NDUFA13 (NADH:Ubiquinone Oxidoreductase Subunit A13). The drugs Sorafenib and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include thyroid.

UniProtKB/Swiss-Prot : 72 Hurthle cell thyroid carcinoma: A rare type of thyroid cancer accounting for only about 3-10% of all differentiated thyroid cancers. These neoplasms are considered a variant of follicular carcinoma of the thyroid and are referred to as follicular carcinoma, oxyphilic type.

Related Diseases for Thyroid Carcinoma, Hurthle Cell

Diseases related to Thyroid Carcinoma, Hurthle Cell via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 thyroid gland hurthle cell carcinoma 11.4
2 lipomatosis, multiple 10.2
3 thyroid carcinoma, familial medullary 10.2
4 thyroid cancer, nonmedullary, 1 10.2
5 graves disease 1 10.2
6 pleomorphic lipoma 10.2
7 thyroid gland follicular carcinoma 10.2
8 thyroid gland medullary carcinoma 10.2
9 rare tumor 10.2
10 papillary carcinoma 10.2
11 thyroiditis 10.2
12 liposarcoma 10.1
13 thyroid carcinoma 10.1
14 hemangioma 10.1
15 adenoma 10.1
16 thyroid tumor 10.1
17 osteogenic sarcoma 10.0
18 neurofibromatosis 10.0
19 posttransplant acute limbic encephalitis 10.0
20 differentiated thyroid carcinoma 9.5 TG NDUFA13

Graphical network of the top 20 diseases related to Thyroid Carcinoma, Hurthle Cell:



Diseases related to Thyroid Carcinoma, Hurthle Cell

Symptoms & Phenotypes for Thyroid Carcinoma, Hurthle Cell

Clinical features from OMIM®:

607464 (Updated 20-May-2021)

Drugs & Therapeutics for Thyroid Carcinoma, Hurthle Cell

Drugs for Thyroid Carcinoma, Hurthle Cell (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
2
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
3
Iodine Approved, Investigational Phase 2 7553-56-2 807
4
Cadexomer iodine Experimental Phase 2 94820-09-4
5 Immunosuppressive Agents Phase 2
6 Immunologic Factors Phase 2
7 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Phase II Study of Sorafenib With or Without Everolimus in Patients With Radioactive Iodine Refractory Hurthle Cell Thyroid Cancer Active, not recruiting NCT02143726 Phase 2 sorafenib;everolimus
2 Studies on Thyroid Nodules and Thyroid Cancer Recruiting NCT00001160

Search NIH Clinical Center for Thyroid Carcinoma, Hurthle Cell

Genetic Tests for Thyroid Carcinoma, Hurthle Cell

Genetic tests related to Thyroid Carcinoma, Hurthle Cell:

# Genetic test Affiliating Genes
1 Hurthle Cell Carcinoma of Thyroid 29 NDUFA13

Anatomical Context for Thyroid Carcinoma, Hurthle Cell

MalaCards organs/tissues related to Thyroid Carcinoma, Hurthle Cell:

40
Thyroid

Publications for Thyroid Carcinoma, Hurthle Cell

Articles related to Thyroid Carcinoma, Hurthle Cell:

(show all 11)
# Title Authors PMID Year
1
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. 57 6
15841082 2005
2
RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. 57
12727991 2003
3
High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor gene. 57
12364463 2002
4
Chromosomal aberrations by comparative genomic hybridization in hürthle cell thyroid carcinomas are associated with tumor recurrence. 57
12364440 2002
5
Follicular and Hürthle cell carcinoma: predicting outcome and directing therapy. 57
9854570 1998
6
Additional Surgery for Occult Risk Factors After Lobectomy in Solitary Thyroid Nodules is Predicted by Cytopathology Classification and Tumor Size. 61
33471644 2020
7
Issues in Managing Hurthle Cell Carcinoma of Thyroid: A Case Report. 61
28507839 2017
8
Familial Hurthle cell carcinoma of the thyroid: case reports and review of the literature. 61
19585901 2009
9
Fine needle aspiration cytology of unsuspected metastatic hurthle cell carcinoma of the thyroid and its pitfalls: a report of two cases. 61
17580356 2007
10
A rare case of Hurthle cell carcinoma with endobronchial metastasis. 61
15118264 2004
11
Scintigraphy with [111In]octreotide and 201Tl in a Hürthle cell thyroid carcinoma without detectable radio-iodine uptake. Report of a case and review of the literature. 54
14530610 2003

Variations for Thyroid Carcinoma, Hurthle Cell

ClinVar genetic disease variations for Thyroid Carcinoma, Hurthle Cell:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 NDUFA13 NM_015965.7(NDUFA13):c.15G>C (p.Lys5Asn) SNV Pathogenic 1693 rs137852869 GRCh37: 19:19627062-19627062
GRCh38: 19:19516253-19516253

Expression for Thyroid Carcinoma, Hurthle Cell

Search GEO for disease gene expression data for Thyroid Carcinoma, Hurthle Cell.

Pathways for Thyroid Carcinoma, Hurthle Cell

GO Terms for Thyroid Carcinoma, Hurthle Cell

Sources for Thyroid Carcinoma, Hurthle Cell

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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