TCO
MCID: THY116
MIFTS: 17

Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia (TCO)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

MalaCards integrated aliases for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia:

Name: Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia 57
Nonmedullary Thyroid Carcinoma, with or Without Cell Oxyphilia 20 70
Thyroid Carcinoma, Nonmedullary, with Cell Oxyphilia 57 13
Tco 57 20
Tco 1 20
Tco1 57

Classifications:



External Ids:

OMIM® 57 603386
MedGen 41 C1863925
UMLS 70 C1863925

Summaries for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

OMIM® : 57 The familial form of nonmedullary thyroid carcinoma (NMTC) is a complex genetic disorder characterized by multifocal neoplasia and a higher degree of aggressiveness than its sporadic counterpart. One peculiar form of thyroid tumors is characterized by the presence of cell oxyphilia. Oxophil cells are found in a minority of thyroid tumors, either benign or malignant. These cells show a large volume of granular eosinophilic cytoplasm and are very rich in mitochondria. The familial occurrence of thyroid tumors with cell oxyphilia was reported by Katoh et al. (1998). Canzian et al. (1998) reported such a family with affected members in 3 generations and by linkage analysis mapped the gene to 19p13. For general phenotypic information and a discussion of genetic heterogeneity of NMTC, see 188550. (603386) (Updated 20-May-2021)

MalaCards based summary : Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia, also known as nonmedullary thyroid carcinoma, with or without cell oxyphilia, is related to thyroid carcinoma and goiter, multinodular 1, with or without sertoli-leydig cell tumors. An important gene associated with Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia is TCO (Thyroid Carcinoma, Nonmedullary, With Cell Oxyphilia). Affiliated tissues include thyroid.

Related Diseases for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Diseases related to Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma 10.3
2 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.2
3 thyroid cancer, nonmedullary, 1 10.2
4 goiter 10.2
5 familial papillary or follicular thyroid carcinoma 10.1
6 adenoma 10.0
7 thyroid carcinoma, familial medullary 9.9
8 thyroid cancer, nonmedullary, 3 9.9
9 parathyroid carcinoma 9.9
10 laryngotracheitis 9.9
11 familial adenomatous polyposis 9.9
12 multinodular goiter 9.9
13 primary hyperparathyroidism 9.9
14 hyperparathyroidism 9.9
15 thyroid gland medullary carcinoma 9.9
16 thyroid gland disease 9.9
17 thyroiditis 9.9
18 parathyroid adenoma 9.9
19 familial nonmedullary thyroid carcinoma 9.9

Graphical network of the top 20 diseases related to Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia:



Diseases related to Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Symptoms & Phenotypes for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Clinical features from OMIM®:

603386 (Updated 20-May-2021)

Drugs & Therapeutics for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Search Clinical Trials , NIH Clinical Center for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Genetic Tests for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Anatomical Context for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

MalaCards organs/tissues related to Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia:

40
Thyroid

Publications for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Articles related to Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia:

(show all 20)
# Title Authors PMID Year
1
A comprehensive analysis of MNG1, TCO1, fPTC, PTEN, TSHR, and TRKA in familial nonmedullary thyroid cancer: confirmation of linkage to TCO1. 61 57
11502798 2001
2
Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid. 57
15841082 2005
3
Evidence for interaction between the TCO and NMTC1 loci in familial non-medullary thyroid cancer. 57
15173224 2004
4
Histology of familial thyroid tumours linked to a gene mapping to chromosome 19p13.2. 57
10547601 1999
5
A gene predisposing to familial thyroid tumors with cell oxyphilia maps to chromosome 19p13.2. 57
9837827 1998
6
Solitary, multiple, and familial oxyphil tumours of the thyroid gland. 57
10211119 1998
7
Familial papillary carcinoma of the thyroid. 57
9186475 1997
8
Synergistic Effects of Lenvatinib (E7080) and MEK Inhibitors against Anaplastic Thyroid Cancer in Preclinical Models. 61
33670725 2021
9
UmTco1, a Hybrid Histidine Kinase Gene, Is Essential for the Sexual Development and Virulence of Ustilago maydis. 61
28237997 2017
10
The sixth HAMP domain negatively regulates the activity of the group III HHK containing seven HAMP domains. 61
23876316 2013
11
Two-component signal transduction in Agaricus bisporus: a comparative genomic analysis with other basidiomycetes through the web-based tool BASID2CS. 61
23123423 2013
12
A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 61
22080454 2012
13
Allelic loss of susceptibility loci and the occurrence of BRAF and RAS mutations in patients with familial non-medullary thyroid cancer. 61
21826673 2012
14
Oxygen-dependent, alternative promoter controls translation of tco1+ in fission yeast. 61
18276645 2008
15
A link between virulence and homeostatic responses to hypoxia during infection by the human fungal pathogen Cryptococcus neoformans. 61
17319742 2007
16
A unique fungal two-component system regulates stress responses, drug sensitivity, sexual development, and virulence of Cryptococcus neoformans. 61
16672377 2006
17
Contributions of baroreceptor reflex to the hypothermic effect of intraventricular angiotensin II in rats. 61
4046235 1985
18
Baroreflexive suppression of heat production and fall in body temperature following peripheral administration of vasopressin in rats. 61
6492492 1984
19
Enhancement of calorigenic response to cold and to norepinephrine in physically trained rats. 61
7328915 1981
20
Calorigenic and cardiovascular responses to norepinephrine in anesthetized and unanesthetized control and cold-acclimated rats. 61
7300040 1981

Variations for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Expression for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Search GEO for disease gene expression data for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia.

Pathways for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

GO Terms for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Sources for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
17 EFO
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20 GARD
28 GO
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30 HMDB
31 HPO
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45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
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53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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