TCO
MCID: THY116
MIFTS: 14

Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia (TCO)

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

MalaCards integrated aliases for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia:

Name: Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia 57
Nonmedullary Thyroid Carcinoma, with or Without Cell Oxyphilia 53 73
Thyroid Carcinoma, Nonmedullary, with Cell Oxyphilia 57 13
Tco 57 53
Tco 1 53
Tco1 57

Classifications:



External Ids:

OMIM 57 603386
MedGen 42 C1863925
UMLS 73 C1863925

Summaries for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

OMIM : 57 The familial form of nonmedullary thyroid carcinoma (NMTC) is a complex genetic disorder characterized by multifocal neoplasia and a higher degree of aggressiveness than its sporadic counterpart. One peculiar form of thyroid tumors is characterized by the presence of cell oxyphilia. Oxophil cells are found in a minority of thyroid tumors, either benign or malignant. These cells show a large volume of granular eosinophilic cytoplasm and are very rich in mitochondria. The familial occurrence of thyroid tumors with cell oxyphilia was reported by Katoh et al. (1998). Canzian et al. (1998) reported such a family with affected members in 3 generations and by linkage analysis mapped the gene to 19p13. For general phenotypic information and a discussion of genetic heterogeneity of NMTC, see 188550. (603386)

MalaCards based summary : Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia, also known as nonmedullary thyroid carcinoma, with or without cell oxyphilia, is related to thyroid cancer, nonmedullary, 1 and thyroid carcinoma, familial medullary. An important gene associated with Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia is TCO (Thyroid Carcinoma, Nonmedullary, With Cell Oxyphilia). The drugs Abraxane and Abstral have been mentioned in the context of this disorder. Affiliated tissues include thyroid.

Related Diseases for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Diseases related to Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 thyroid cancer, nonmedullary, 1 10.2
2 thyroid carcinoma, familial medullary 10.1
3 laryngotracheitis 10.1

Symptoms & Phenotypes for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Clinical features from OMIM:

603386

Drugs & Therapeutics for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

FDA approved drugs:

(show all 30)
# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Abraxane 18 49 PACLITAXEL Celgene October 2012
2
Abstral 18 FENTANYL (citrate) ProStrakan January 2011
3
Adcetris 18 49 BRENTUXIMAB VEDOTIN Seattle Genetics August 2011
4
Afinitor 18 49 EVEROLIMUS Novartis March 2009
5
Cometriq 18 49 CABOZANTINIB S-MALATE Exelixis November 2012
6
Cyramza 18 49 RAMUCIRUMAB Eli Lilly April 2014
7
Erbitux 18 49 CETUXIMAB Imclone, Bristol-Myers Squibb February 2004
8
Erivedge 18 49 VISMODEGIB Genentech January 2012
9
Evista 18 49 RALOXIFENE HYDROCHLORIDE Eli Lilly September 2007
10
Gardasil 18 49 quadrivalent human papillomavirus (types 6, 11, 16, 18) recombinant vaccine Merck June 2006
11
Gilotrif 18 49 AFATINIB DIMALEATE Boehringer Ingelheim July 2013
12
Halaven 18 49 ERIBULIN MESYLATE Eisai November 2010
13
Keytruda 18 49 PEMBROLIZUMAB Merck September 2014
14
Kytril 18 GRANISETRON HYDROCHLORIDE Roche/SmithKline Beecham June 2001/ November 1997
15
Lazanda 18 FENTANYL CITRATE Archimedes June 2011
16
Onsolis 18 FENTANYL CITRATE BioDelivery Sciences July 2009
17
Opdivo 18 49 NIVOLUMAB Bristol-Myers Squibb March 2015/ December 2014, March 2015
18
Sutent 18 49 SUNITINIB MALATE Pfizer May 2011/ January 2006
19
Sylatron 18 49 PEGINTERFERON ALFA-2B Merck April 2011
20
Xgeva 18 49 DENOSUMAB Amgen June 2013/ November 2010
21
Zelboraf 18 49 VEMURAFENIB Roche August of 2011
22
Zofran 18 49 ONDANSETRON HYDROCHLORIDE GlaxoSmithKline January 1999/ April 1998
23
Zykadia 18 49 CERITINIB Novartis April 2014
24
Advair 18 FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE GlaxoSmithKline August 2000
25
Aldurazyme 18 LARONIDASE Genzyme May 2003
26
Daliresp 18 ROFLUMILAST Forest Pharmaceuticals February 2011
27
Ketek 18 TELITHROMYCIN Sanofi-aventis April 2004
28
Portazza 18 NECITUMUMAB Eli Lilly November 2015
29
Sirturo 18 BEDAQUILINE FUMARATE Janssen Therapeutics December 2012
30
Spiriva HandiHaler 18 TIOTROPIUM BROMIDE Boehringer Ingelheim February 2004

Search Clinical Trials , NIH Clinical Center for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Genetic Tests for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Anatomical Context for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

MalaCards organs/tissues related to Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia:

41
Thyroid

Publications for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Variations for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Expression for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Search GEO for disease gene expression data for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia.

Pathways for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

GO Terms for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

Sources for Thyroid Carcinoma, Nonmedullary, with or Without Cell Oxyphilia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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