PRN1
MCID: THY065
MIFTS: 23

Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia (PRN1)

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

MalaCards integrated aliases for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia:

Name: Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia 57 13 70
Familial Papillary Thyroid Carcinoma with Renal Papillary Neoplasia 58
Ptc-Rcc 58
Ptcprn 57
Prn1 57

Characteristics:

Orphanet epidemiological data:

58

Classifications:

Orphanet: 58  
Rare renal diseases
Rare endocrine diseases


External Ids:

OMIM® 57 605642
ICD10 via Orphanet 33 C64 C73
UMLS via Orphanet 71 C1854104
Orphanet 58 ORPHA97290
MedGen 41 C1854104
UMLS 70 C1854104

Summaries for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

MalaCards based summary : Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia, also known as familial papillary thyroid carcinoma with renal papillary neoplasia, is related to helix syndrome. An important gene associated with Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia is PTCPRN (Papillary Thyroid Carcinoma With Papillary Renal Neoplasia). Affiliated tissues include thyroid, kidney and colon, and related phenotypes are nodular goiter and papillary renal cell carcinoma

More information from OMIM: 605642

Related Diseases for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Diseases related to Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 helix syndrome 10.0

Symptoms & Phenotypes for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Human phenotypes related to Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia:

58 31 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 nodular goiter 58 31 hallmark (90%) Very frequent (99-80%) HP:0005994
2 papillary renal cell carcinoma 58 31 hallmark (90%) Very frequent (99-80%) HP:0006766
3 papillary thyroid carcinoma 58 31 hallmark (90%) Very frequent (99-80%) HP:0002895
4 neoplasm of head and neck 58 31 hallmark (90%) Very frequent (99-80%) HP:0012288
5 abnormality of neck blood vessel 58 31 hallmark (90%) Very frequent (99-80%) HP:3000037
6 chronic noninfectious lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002730
7 colon cancer 58 31 occasional (7.5%) Occasional (29-5%) HP:0003003
8 recurrent fractures 58 31 occasional (7.5%) Occasional (29-5%) HP:0002757
9 breast carcinoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0003002
10 chronic lung disease 58 31 occasional (7.5%) Occasional (29-5%) HP:0006528
11 renal cortical adenoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0006735
12 renal oncocytoma 58 31 occasional (7.5%) Occasional (29-5%) HP:0011798
13 goiter 58 Frequent (79-30%)
14 abnormality of the lymph nodes 58 Frequent (79-30%)

Clinical features from OMIM®:

605642 (Updated 05-Apr-2021)

Drugs & Therapeutics for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Search Clinical Trials , NIH Clinical Center for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Genetic Tests for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Anatomical Context for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

MalaCards organs/tissues related to Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia:

40
Thyroid, Kidney, Colon, Lung, Breast

Publications for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Articles related to Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia:

(show top 50) (show all 77)
# Title Authors PMID Year
1
Papillary thyroid carcinoma associated with papillary renal neoplasia: genetic linkage analysis of a distinct heritable tumor syndrome. 57
10843148 2000
2
Familial papillary thyroid carcinoma is genetically distinct from familial adenomatous polyposis coli. 57
10211600 1999
3
Protein Side-Chain-DNA Contacts Probed by Fast Magic-Angle Spinning NMR. 61
33238710 2020
4
The First Report of Macrolide-Resistant Bordetella pertussis Isolation in Japan. 61
32350216 2020
5
Comparative genomics of whole-cell pertussis vaccine strains from India. 61
32381023 2020
6
Clinical characteristics, molecular epidemiology and antimicrobial susceptibility of pertussis among children in southern China. 61
31493136 2020
7
High Prevalence of Macrolide-Resistant Bordetella pertussis and ptxP1 Genotype, Mainland China, 2014-2016. 61
31742507 2019
8
Experimental pKa Value Determination of All Ionizable Groups of a Hyperstable Protein. 61
30511779 2019
9
Bordetella pertussis Infection in Infants and Young Children in Shanghai, China, 2016-2017: Clinical Features, Genotype Variations of Antigenic Genes and Macrolides Resistance. 61
30882726 2019
10
[Antimicrobial susceptibility and antigen genotypes of Bordetella pertussis strains isolated from neonates]. 61
30907341 2019
11
A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template. 61
30595448 2019
12
Pertussis Outbreak in a Primary School in China: Infection and Transmission of the Macrolide-resistant Bordetella pertussis. 61
29088029 2018
13
Arabidopsis thaliana extracts optimized for polyphenols production as potential therapeutics for the APOE-modulated neuroinflammation characteristic of Alzheimer's disease in vitro. 61
27383500 2016
14
Direct molecular typing of Bordetella pertussis from nasopharyngeal specimens in China in 2012-2013. 61
27146879 2016
15
Disruption of the gene encoding restriction endonuclease SuaI and development of a host-vector system for the thermoacidophilic archaeon Sulfolobus acidocaldarius. 61
26791382 2016
16
Molecular epidemiology of Bordetella pertussis in the Philippines in 2012-2014. 61
25861926 2015
17
Colonization of Bordetella pertussis clinical isolates that differ by pulsed field gel electrophoresis types in the lungs of naïve mice or mice immunized with the whole-cell pertussis vaccine used in Poland. 61
25297678 2015
18
Improvement of a Sulfolobus-E. coli shuttle vector for heterologous gene expression in Sulfolobus acidocaldarius. 61
25293629 2015
19
Variation in Bordetella pertussis Susceptibility to Erythromycin and Virulence-Related Genotype Changes in China (1970-2014). 61
26406905 2015
20
Sequence variation in virulence-related genes of Bordetella pertussis isolates from Poland in the period 1959-2013. 61
25090968 2015
21
Genetic Variation of Bordetella pertussis in Austria. 61
26182210 2015
22
Identification of the minimal replicon and the origin of replication of the crenarchaeal plasmid pRN1. 61
25060695 2014
23
Pertussis outbreak, southeastern Minnesota, 2012. 61
25282430 2014
24
Consistency of Bordetella pertussis vaccine seed strains and potency of whole-cell pertussis vaccine still in use in Poland. 61
24457195 2014
25
Pirin1 (PRN1) is a multifunctional protein that regulates quercetin, and impacts specific light and UV responses in the seed-to-seedling transition of Arabidopsis thaliana. 61
24705271 2014
26
Solute diffusion in ionic liquids, NMR measurements and comparisons to conventional solvents. 61
23968276 2013
27
Endogenous mutagenesis in recombinant sulfolobus plasmids. 61
23564176 2013
28
Susceptibility of intact germinating Arabidopsis thaliana to human fungal pathogens Cryptococcus neoformans and C. gattii. 61
23435895 2013
29
Functional characterization of the origin of replication of pRN1 from Sulfolobus islandicus REN1H1. 61
24376833 2013
30
Versatile Genetic Tool Box for the Crenarchaeote Sulfolobus acidocaldarius. 61
22707949 2012
31
Prevalence and genetic characterization of pertactin-deficient Bordetella pertussis in Japan. 61
22348138 2012
32
Strain variation among Bordetella pertussis isolates circulating in Poland after 50 years of whole-cell pertussis vaccine use. 61
21307213 2011
33
Studies on Prn variation in the mouse model and comparison with epidemiological data. 61
21464955 2011
34
Structure and function of the primase domain of the replication protein from the archaeal plasmid pRN1. 61
21265755 2011
35
Effect of vaccination on Bordetella pertussis strains, China. 61
21029526 2010
36
The archaeo-eukaryotic primase of plasmid pRN1 requires a helix bundle domain for faithful primer synthesis. 61
20511586 2010
37
Synergic effect of genotype changes in pertussis toxin and pertactin on adaptation to an acellular pertussis vaccine in the murine intranasal challenge model. 61
20357056 2010
38
Bordetella pertussis vaccine strains and circulating isolates in Serbia. 61
19945417 2010
39
DNA translocation activity of the multifunctional replication protein ORF904 from the archaeal plasmid pRN1. 61
19762479 2009
40
Structure-based stability analysis of an extremely stable dimeric DNA binding protein from Sulfolobus islandicus. 61
19788170 2009
41
Molecular biology of the pRN1 plasmid from Sulfolobus islandicus. 61
19143599 2009
42
Molecular modeling and functional characterization of the monomeric primase-polymerase domain from the Sulfolobus solfataricus plasmid pIT3. 61
18671730 2008
43
Antigenic variation in Bordetella pertussis isolates recovered from adults and children in Japan. 61
18291563 2008
44
Opposite ends of the spectrum: plant and animal g-protein signaling. 61
19704591 2007
45
Pulsed-field gel electrophoresis, pertactin, pertussis toxin S1 subunit polymorphisms, and surfaceome analysis of vaccine and clinical Bordetella pertussis strains. 61
17699837 2007
46
The GCR1, GPA1, PRN1, NF-Y signal chain mediates both blue light and abscisic acid responses in Arabidopsis. 61
17322342 2007
47
Characterization of the transcriptional activity of the cryptic plasmid pRN1 from Sulfolobus islandicus REN1H1 and regulation of its replication operon. 61
17172324 2007
48
Antigenic divergence between Bordetella pertussis clinical isolates from Moscow, Russia, and vaccine strains. 61
17202309 2007
49
Small multicopy, non-integrative shuttle vectors based on the plasmid pRN1 for Sulfolobus acidocaldarius and Sulfolobus solfataricus, model organisms of the (cren-)archaea. 61
17576673 2007
50
Properties of an unusual DNA primase from an archaeal plasmid. 61
17709343 2007

Variations for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Expression for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Search GEO for disease gene expression data for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia.

Pathways for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

GO Terms for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Sources for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

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