PRN1
MCID: THY065
MIFTS: 22

Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia (PRN1)

Categories: Cancer diseases, Endocrine diseases, Genetic diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

MalaCards integrated aliases for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia:

Name: Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia 58 74
Familial Papillary Thyroid Carcinoma with Renal Papillary Neoplasia 60
Papillary Thyroid Carcinoma with Papillary Renal Neoplasia 13
Ptc-Rcc 60
Ptcprn 58
Prn1 58

Characteristics:

Orphanet epidemiological data:

60

Classifications:



External Ids:

OMIM 58 605642
ICD10 via Orphanet 35 C64 C73
UMLS via Orphanet 75 C1854104
Orphanet 60 ORPHA97290
MedGen 43 C1854104
UMLS 74 C1854104

Summaries for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

MalaCards based summary : Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia, is also known as familial papillary thyroid carcinoma with renal papillary neoplasia. An important gene associated with Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia is PTCPRN (Papillary Thyroid Carcinoma With Papillary Renal Neoplasia). The drugs Hydromorphone and Oxycodone have been mentioned in the context of this disorder. Affiliated tissues include thyroid, colon and lymph node, and related phenotypes are papillary thyroid carcinoma and papillary renal cell carcinoma

Description from OMIM: 605642

Related Diseases for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Symptoms & Phenotypes for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Human phenotypes related to Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia:

60 33 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 papillary thyroid carcinoma 60 33 hallmark (90%) Very frequent (99-80%) HP:0002895
2 papillary renal cell carcinoma 60 33 hallmark (90%) Very frequent (99-80%) HP:0006766
3 nodular goiter 60 33 hallmark (90%) Very frequent (99-80%) HP:0005994
4 neoplasm of head and neck 60 33 hallmark (90%) Very frequent (99-80%) HP:0012288
5 abnormality of neck blood vessel 60 33 hallmark (90%) Very frequent (99-80%) HP:3000037
6 chronic noninfectious lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0002730
7 colon cancer 60 33 occasional (7.5%) Occasional (29-5%) HP:0003003
8 recurrent fractures 60 33 occasional (7.5%) Occasional (29-5%) HP:0002757
9 breast carcinoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0003002
10 renal cortical adenoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0006735
11 renal oncocytoma 60 33 occasional (7.5%) Occasional (29-5%) HP:0011798
12 chronic lung disease 60 33 occasional (7.5%) Occasional (29-5%) HP:0006528
13 goiter 60 Frequent (79-30%)
14 abnormality of the lymph nodes 60 Frequent (79-30%)

Clinical features from OMIM:

605642

Drugs & Therapeutics for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Drugs for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydromorphone Approved, Illicit Phase 1 466-99-9 5284570
2
Oxycodone Approved, Illicit, Investigational Phase 1 76-42-6 5284603
3
Morphine Approved, Investigational Phase 1 57-27-2 5288826
4 Central Nervous System Depressants Phase 1
5 Peripheral Nervous System Agents Phase 1
6 Analgesics, Opioid Phase 1
7 Narcotics Phase 1
8 Analgesics Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dose and Response of Intrathecal Hydromorphone in Patients Undergoing Cesarean Section at Virginia Commonwealth University Health System Terminated NCT02787928 Phase 1 Intrathecal hydromorphone

Search NIH Clinical Center for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Genetic Tests for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Anatomical Context for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

MalaCards organs/tissues related to Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia:

42
Thyroid, Colon, Lymph Node

Publications for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Variations for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Expression for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Search GEO for disease gene expression data for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia.

Pathways for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

GO Terms for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

Sources for Thyroid Carcinoma, Papillary, with Papillary Renal Neoplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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