MCID: THY001
MIFTS: 32

Thyroid Crisis

Categories: Endocrine diseases
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Aliases & Classifications for Thyroid Crisis

MalaCards integrated aliases for Thyroid Crisis:

Name: Thyroid Crisis 11 43 14 16 71 33
Thyrotoxic Crisis 11 33
Thyrotoxic Storm 33
Thyroid Storm 33

Classifications:



External Ids:

Disease Ontology 11 DOID:12837
MeSH 43 D013958
NCIt 49 C112836
SNOMED-CT 68 190262002
ICD11 33 1215823328
UMLS 71 C0040127

Summaries for Thyroid Crisis

MalaCards based summary: Thyroid Crisis, also known as thyrotoxic crisis, is related to graves' disease and graves ophthalmopathy. An important gene associated with Thyroid Crisis is TG (Thyroglobulin), and among its related pathways/superpathways are Thyroid hormones production and peripheral downstream signaling effects and Thyroxine (thyroid hormone) production. Affiliated tissues include thyroid, heart and liver.

Related Diseases for Thyroid Crisis

Diseases related to Thyroid Crisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
# Related Disease Score Top Affiliating Genes
1 graves' disease 30.2 TSHR TPO TG SERPINA7
2 graves ophthalmopathy 30.2 TSHR TG
3 hypothyroidism, congenital, nongoitrous, 1 30.1 TSHR TG
4 nodular goiter 30.1 TSHR TPO TG
5 hypothyroidism, congenital, nongoitrous, 2 29.9 TSHR TG
6 struma ovarii 29.9 TSHR TG
7 suppurative thyroiditis 29.9 TSHR TPO TG
8 turner syndrome 29.9 TPO TG SERPINA7
9 multinodular goiter 29.9 TSHR TPO TG
10 pernicious anemia 29.9 TPO TG
11 thyroid cancer, nonmedullary, 2 29.8 TSHR TG
12 hypoadrenocorticism, familial 29.8 TPO TG POMC
13 thyroiditis 29.7 TSHR TPO TG SERPINA7
14 goiter 29.7 TSHR TPO TG SERPINA7
15 nontoxic goiter 29.7 TSHR TPO TG SERPINA7
16 thyroid gland follicular carcinoma 29.7 TSHR TPO TG
17 subacute thyroiditis 29.7 TSHR TPO TG SERPINA7
18 hashimoto thyroiditis 29.7 TSHR TPO TG SERPINA7
19 thyroid gland anaplastic carcinoma 29.6 TSHR TPO TG
20 adenoma 29.6 TSHR TG POMC
21 graves disease 1 29.6 TSHR TPO TG SLC16A2 SERPINA7 POMC
22 plummer's disease 29.5 TSHR TPO TG SERPINA7
23 celiac disease 1 29.4 TPO TG GPT
24 aspiration pneumonia 29.3 POMC GPT
25 viral hepatitis 29.2 TSHR TPO TG GPT
26 acth deficiency, isolated 29.2 POMC MTUS2 MTUS1
27 diabetes insipidus 29.1 TG POMC
28 acute thyroiditis 29.0 TPO TG SERPINA7 MTUS2 MTUS1
29 hyperthyroidism 29.0 TSHR TPO TG SLC16A2 SERPINA7 POMC
30 myxedema 28.8 TSHR TPO TG SERPINA7 POMC
31 hypothyroidism 28.8 TSHR TPO TG SERPINA7 POMC GPT
32 respiratory failure 10.4
33 pulmonary edema 10.3
34 liver disease 10.3
35 pulmonary embolism 10.3
36 ventricular fibrillation, paroxysmal familial, 1 10.2
37 bilirubin metabolic disorder 10.2
38 tremor 10.2
39 thyroid hormone resistance, selective pituitary 10.2 TG SERPINA7
40 mechanical strabismus 10.2 TPO TG
41 mitral valve insufficiency 10.2
42 dilated cardiomyopathy 10.2
43 nonencapsulated sclerosing carcinoma 10.2 TPO TG
44 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.2 TPO TG
45 thyroid lymphoma 10.2 TPO TG
46 orbital disease 10.2 TSHR TG
47 ocular motor apraxia 10.1
48 hypotropia 10.1 TSHR TPO
49 chronic spontaneous urticaria 10.1 TPO TG
50 neutropenia 10.1

Graphical network of the top 20 diseases related to Thyroid Crisis:



Diseases related to Thyroid Crisis

Symptoms & Phenotypes for Thyroid Crisis

Drugs & Therapeutics for Thyroid Crisis

Search Clinical Trials, NIH Clinical Center for Thyroid Crisis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Methimazole
Propylthiouracil

Cochrane evidence based reviews: thyroid crisis

Genetic Tests for Thyroid Crisis

Anatomical Context for Thyroid Crisis

Organs/tissues related to Thyroid Crisis:

MalaCards : Thyroid, Heart, Liver, Pituitary, Adrenal Gland, Brain, Thymus

Publications for Thyroid Crisis

Articles related to Thyroid Crisis:

(show top 50) (show all 1149)
# Title Authors PMID Year
1
[Iodine-induced hyperthyroidism in metastatic thyroid carcinoma]. 53 62
7956798 1994
2
Effect of inactivated and mRNA COVID-19 vaccination on thyroid function among patients treated for hyperthyroidism. 62
36453154 2022
3
[Two cases of ischemic stroke due to low protein C caused by severe hyperthyroidism]. 62
36288963 2022
4
Thyroid storm in pediatrics: a systematic review. 62
36318760 2022
5
Indications for ordering thyroid-stimulating hormone in noncritically ill adult inpatients-A Delphi consensus recommendation. 62
35694880 2022
6
Myopathic dysphagia caused by thyrotoxicosis: a case report and review of the literature. 62
36448823 2022
7
Estimating Incidence and Case Fatality of Thyroid Storm in Germany Between 2007 and 2017: A Claims Data Analysis. 62
36006371 2022
8
Thyroid storm induced by combined nivolumab and ipilimumab immunotherapy in advanced non-small cell lung cancer. 62
36223974 2022
9
Severe cholestasis due to a thyrotoxic crisis. 62
35945060 2022
10
Ruptured appendicitis with undiagnosed Graves' disease: Contrast-induced impending thyroid storm. 62
36268445 2022
11
Cardiogenic shock due to Takotsubo cardiomyopathy associated with thyroid crisis: a case report. 62
36237226 2022
12
Cardiovascular Collapse Secondary to Beta-Blocker Administration in a Setting of Coexisting Thyroid Storm and Atrial Fibrillation: A Case Report. 62
36277558 2022
13
The Endoscopic Endonasal Transsphenoidal Approach for Thyrotropin-Secreting Pituitary Adenomas: Single-Center Experience and Clinical Outcomes of 49 Patients. 62
36096394 2022
14
How to survive the thyroid storm: what we can learn from case reports. 62
35871022 2022
15
Endocrine Emergencies During Pregnancy: Diabetic Ketoacidosis and Thyroid Storm. 62
36122980 2022
16
Granulomatosis With Polyangiitis in Untreated Graves' Disease: A Rare Event. 62
36340518 2022
17
Clinical Pharmacokinetics of Metoprolol: A Systematic Review. 62
35764772 2022
18
Impending myocardial ischaemia during thyroid storm diagnosed through Wellens' syndrome. 62
36028243 2022
19
High scored thyroid storm after stomach cancer perforation: A case report. 62
36157821 2022
20
Thyroid storm complicated by corpus callosum infarction in a young patient: A case report and literature review. 62
36042649 2022
21
Update on Pediatric Hyperthyroidism. 62
35985711 2022
22
Acute right ventricular failure evoked by trauma induced thyroid storm supported by extracorporeal membrane oxygenation: A case report. 62
35960049 2022
23
[Multimodal anesthesia in a patient with Graves' disease and thyrotoxicosis: A case report]. 62
36049082 2022
24
Iodinated Contrast-Induced Thyroid Storm With Concomitant Cardiac Tamponade: A Case Report. 62
36134087 2022
25
Clinical Review and Update on the Management of Thyroid Storm. 62
36118802 2022
26
Cerebral venous sinus thrombosis caused by traumatic brain injury complicating thyroid storm: a case report and discussion. 62
35794521 2022
27
Diagnosis and management of intraoperative thyroid storm in a child with undiagnosed Graves' disease: a case report. 62
35841430 2022
28
Endocrine Emergencies in the Medical Intensive Care Unit. 62
35617093 2022
29
Correlation between medical management and teamwork in multidisciplinary high-fidelity obstetrics simulations. 62
35351671 2022
30
Septic shock in a woman with a hydatidiform mole: A case report. 62
35574176 2022
31
Diabetic Ketoacidosis and Thyroid Storm Presentation of Two Jeopardies Concurrently in a Young Female. 62
36185966 2022
32
A Young Female With Thyroid Storm and Pulmonary Embolus: A Case Study. 62
35812622 2022
33
Thyrotoxicosis occurrence in SARS-CoV-2 infection: A case report. 62
35505686 2022
34
Acute cerebral infarction combined with a thyroid storm in a patient with both Moyamoya syndrome and Graves' disease. 62
34696552 2022
35
Flash Pulmonary Edema: A Rare Presentation of Graves' Disease. 62
35836449 2022
36
Severe Cardiovascular Effects of Prolonged Untreated Hyperthyroidism Manifesting As Thyroid Storm. 62
35898385 2022
37
Non-diabetic ketoacidosis secondary to primary hyperthyroidism: A case report. 62
35687767 2022
38
SARS-CoV-2 infection induced thyroid storm and heart failure in an adolescent girl. 62
34657643 2022
39
The emerging role of transcription factor FOXP3 in thyroid cancer. 62
34463908 2022
40
Supraventricular Tachycardia: An Atypical Presentation of Thyroid Storm. 62
35774700 2022
41
Thyroid Storm Caused by Hyperemesis Gravidarum. 62
35602873 2022
42
Takotsubo cardiomyopathy in the setting of thyroid storm. 62
35550326 2022
43
Just an Acute Pulmonary Edema? Paraneoplastic Thyroid Storm Due to Invasive Mole. 62
35813694 2022
44
Risk of sudden cardiac death in a case of spontaneous coronary artery dissection presenting with thyroid storm. 62
35647853 2022
45
Systematic review of COVID-19 and autoimmune thyroiditis. 62
35307540 2022
46
Continuous improvement of both hepatic and cardiac dysfunction by sequential plasma exchange in a patient with thyrotoxicosis and cardiogenic shock: a case report indicating the potential role of cardiohepatic interactions during thyroid storm. 62
35620268 2022
47
Extracorporeal membrane oxygenation support and total thyroidectomy in patients with refractory thyroid storm: case series and literature review. 62
35592452 2022
48
Thyroid Storm in an Adolescent Girl Precipitated by Empyema Thoracis. 62
35712374 2022
49
The Perfect Storm: A Case of Thyrotoxic Crisis Masking as Altered Mental Status in the South Bronx. 62
35651453 2022
50
Thyroid Storm in a Patient With Alemtuzumab-Induced Graves' Disease: A Case Report. 62
35651398 2022

Variations for Thyroid Crisis

Expression for Thyroid Crisis

Search GEO for disease gene expression data for Thyroid Crisis.

Pathways for Thyroid Crisis

Pathways related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.05 TSHR SLC16A2 POMC
2 10.1 TSHR TPO TG

GO Terms for Thyroid Crisis

Cellular components related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.36 TPO TG SERPINA7 POMC MTUS1 GPT

Biological processes related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone biosynthetic process GO:0042446 9.56 TPO TG
2 thyroid hormone transport GO:0070327 9.46 SLC16A2 SERPINA7
3 thyroid hormone metabolic process GO:0042403 9.13 TG SLC16A2
4 thyroid hormone generation GO:0006590 9.1 TPO TG SLC16A2

Sources for Thyroid Crisis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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