MCID: THY001
MIFTS: 35

Thyroid Crisis

Categories: Endocrine diseases

Aliases & Classifications for Thyroid Crisis

MalaCards integrated aliases for Thyroid Crisis:

Name: Thyroid Crisis 12 45 15 17 74
Thyrotoxic Crisis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12837
MeSH 45 D013958
NCIt 51 C112836
SNOMED-CT 69 29028009
UMLS 74 C0040127

Summaries for Thyroid Crisis

MalaCards based summary : Thyroid Crisis, also known as thyrotoxic crisis, is related to subacute thyroiditis and hyperthyroidism. An important gene associated with Thyroid Crisis is SERPINA7 (Serpin Family A Member 7), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Methimazole and Hormones, Hormone Substitutes, and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid and testes, and related phenotype is homeostasis/metabolism.

Wikipedia : 77 Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the... more...

Related Diseases for Thyroid Crisis

Diseases related to Thyroid Crisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 subacute thyroiditis 30.4 SERPINA7 TG
2 hyperthyroidism 30.3 SERPINA7 TG THRB
3 acute thyroiditis 30.0 POMC TG
4 thyroiditis 29.9 SERPINA7 TG THRB
5 acute kidney tubular necrosis 29.5 ALB MB
6 hypothyroidism 29.2 POMC SERPINA7 TG THRB TTR
7 dyshormonogenic goiter 10.4 SERPINA7 TG
8 hypothyroidism, congenital, nongoitrous, 2 10.4 SERPINA7 TG
9 nontoxic goiter 10.3 SERPINA7 TG
10 toxic diffuse goiter 10.3 SERPINA7 TG
11 plummer's disease 10.3 TG THRB
12 postsurgical hypothyroidism 10.3 MB TG
13 endocrine exophthalmos 10.3 POMC TG
14 hypoadrenalism 10.3 POMC TG
15 autoimmune disease of endocrine system 10.3 SERPINA7 TG
16 water-clear cell adenoma 10.2 PTH TG
17 clear cell adenoma 10.2 PTH TG
18 cerebral arteritis 10.2 F8 KANTR
19 goiter 10.2 SERPINA7 TG THRB
20 pericardium cancer 10.2 F8 MB
21 graves disease 1 10.2 SERPINA7 TG THRB
22 thyroid hormone resistance, generalized, autosomal dominant 10.2 SERPINA7 TG THRB
23 chromophobe adenoma 10.2 POMC SERPINA7
24 posterior myocardial infarction 10.2 KANTR MB
25 subendocardial myocardial infarction 10.2 KANTR MB
26 scleredema adultorum 10.2 POMC PTH
27 amyloid tumor 10.2 TG TTR
28 visual agnosia 10.2 KANTR MB
29 glossopharyngeal neuralgia 10.1 KANTR POMC
30 thymus lipoma 10.1 MB PTH
31 laryngeal tuberculosis 10.1 KANTR POMC
32 hypothyroidism, congenital, nongoitrous, 4 10.1 POMC SERPINA7 TG
33 cardiovascular organ benign neoplasm 10.1 KANTR MB
34 benign perivascular tumor 10.1 KANTR MB
35 myxedema 10.1
36 diabetes mellitus, ketosis-prone 10.1
37 abducens nerve disease 10.1 KANTR POMC
38 nodular nonsuppurative panniculitis 10.1 F8 POMC
39 tibial neuropathy 10.1 POMC TTR
40 tarsal tunnel syndrome 10.1 POMC TTR
41 endemic goiter 10.1 PTH SERPINA7 TG
42 cloacogenic carcinoma 10.1 POMC PTH
43 thyroid cancer, nonmedullary, 2 10.1 POMC TG THRB
44 neurodermatitis 10.1 KANTR POMC
45 premenstrual tension 10.1 KANTR POMC
46 tsh producing pituitary tumor 10.1 POMC TTR
47 fournier gangrene 10.0 ALB F8
48 brown-sequard syndrome 10.0 KANTR TTR
49 noma 10.0 ALB POMC
50 mineral metabolism disease 10.0 POMC PTH

Graphical network of the top 20 diseases related to Thyroid Crisis:



Diseases related to Thyroid Crisis

Symptoms & Phenotypes for Thyroid Crisis

MGI Mouse Phenotypes related to Thyroid Crisis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 ALB F8 MB POMC PTH TG

Drugs & Therapeutics for Thyroid Crisis

Drugs for Thyroid Crisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methimazole Approved Phase 4 60-56-0 1349907
2 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
3 Hormone Antagonists Phase 4
4 Antithyroid Agents Phase 4
5 Hormones Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
2 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole

Search NIH Clinical Center for Thyroid Crisis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: thyroid crisis

Genetic Tests for Thyroid Crisis

Anatomical Context for Thyroid Crisis

MalaCards organs/tissues related to Thyroid Crisis:

42
Thyroid, Testes

Publications for Thyroid Crisis

Articles related to Thyroid Crisis:

(show top 50) (show all 113)
# Title Authors Year
1
A rare complication of bedside tracheotomy: Thyroid crisis. ( 30604713 )
2019
2
Diltiazem-Associated Cardiogenic Shock in Thyrotoxic Crisis. ( 29521654 )
2018
3
Thyrotoxic crisis as an acute clinical presentation in a child. ( 29574428 )
2018
4
Thyroid Crisis in a Patient With Burn Injury. ( 28157789 )
2017
5
Propranolol-Induced Circulatory Collapse in a Patient With Thyroid Crisis and Underlying Thyrocardiac Disease: A Word of Caution. ( 29318163 )
2017
6
Cardiac arrest caused by landiolol in a patient in thyroid crisis. ( 30546666 )
2016
7
Thyrotoxic crisis presenting with jaundice. ( 27338936 )
2016
8
Jaundice Heralding the Onset of Thyrotoxic Crisis. ( 27762123 )
2016
9
Out of the blue! Thyroid crisis. ( 25886440 )
2015
10
Acute severe asthma with thyroid crisis and myasthenia: A case report and literature review. ( 26471346 )
2015
11
Trauma triggering thyrotoxic crisis with lactic acidosis. ( 26604530 )
2015
12
Thyroid Crisis in the Maxillofacial Trauma Patient. ( 25085805 )
2014
13
Successful treatment of thyroid crisis accompanied by hypoglycemia, lactic acidosis, and multiple organ failure. ( 22386356 )
2012
14
Severe hypoglycemia accompanied with thyroid crisis. ( 23198181 )
2012
15
Isolated adrenocorticotropic hormone deficiency associated with Hashimoto's disease and thyroid crisis triggered by head trauma. Case report. ( 22278027 )
2012
16
Acute Cardiac Failure in a Pregnant Woman due to Thyrotoxic Crisis. ( 24804110 )
2012
17
Thyrotoxic crisis associated with gestational trophoblastic disease. ( 21920210 )
2011
18
Severe duodenal hemorrhage induced by Lugol's solution administered for thyroid crisis treatment. ( 20424366 )
2010
19
Thyroid arterial embolization for the treatment of hyperthyroidism in a patient with thyrotoxic crisis. ( 19178883 )
2009
20
Thyroid crisis following interstitial nephritis. ( 18591847 )
2008
21
Successful treatment of gastric perforation with thyrotoxic crisis. ( 19091282 )
2008
22
Utility of esmolol in thyroid crisis. ( 17127774 )
2006
23
Severe starvation hypoglycemia and congestive heart failure induced by thyroid crisis, with accidentally induced severe liver dysfunction and disseminated intravascular coagulation. ( 15805713 )
2005
24
Thyrotoxic crisis induced by cytotoxic chemotherapy. ( 15459765 )
2005
25
Management of thyrotoxic crisis. ( 15850146 )
2005
26
Storm in a T-CUP: thyroid crisis following trauma. ( 14636743 )
2003
27
Fatal thyroid crisis years after two thyroidectomies for graves' disease: is thyroid tissue autotransplantation for postthyroidectomy hypothyroidism worthwhile? ( 12229955 )
2002
28
Differential diagnosis of thyroid crisis and malignant hyperthermia in an anesthetized porcine model. ( 10098596 )
1999
29
Thyrotoxic crisis presenting as acute abdomen. ( 9496295 )
1997
30
Dantrolene and thyroid crisis. ( 7865016 )
1994
31
Reversible neurological complications during thyrotoxic crisis. ( 7868528 )
1994
32
Recognizing thyroid crisis. ( 8265033 )
1993
33
A case of thyroid crisis occurring during surgery. ( 15278567 )
1992
34
Rhabdomyolysis accompanying thyroid crisis: an autopsy case report. ( 1286234 )
1992
35
Thyroid crisis associated with severe hypocalcemia. ( 1865592 )
1991
36
Emergency department management of thyrotoxic crisis with esmolol. ( 1673341 )
1991
37
Thyrotoxic crisis in Graves' disease: indication for immediate surgery. ( 1707465 )
1990
38
Thyrotoxic crisis presenting as status epilepticus. ( 2349191 )
1990
39
Thyrotoxic crisis after emergency laparotomy. A case report. ( 2360122 )
1990
40
Hyperthyroidism: thyroid crisis (storm, thyrotoxic crisis). ( 2668603 )
1989
41
Acute thyroid crisis on induction of anaesthesia. ( 2929904 )
1989
42
Thyroid crisis complicated by cerebral infarction. ( 3689644 )
1987
43
Thyroid crisis. ( 3670755 )
1987
44
Fatal thyrotoxic crisis. ( 3755568 )
1986
45
Atrioventricular and sinoatrial block in thyrotoxic crisis. ( 4074593 )
1985
46
Thyroid crisis presenting as coma. ( 6096063 )
1984
47
Successful treatment of thyrotoxic crisis with plasma exchange. ( 6723341 )
1984
48
A case of thyrotoxic crisis that mimicked malignant hyperthermia. ( 6881599 )
1983
49
Thyrotoxic crisis following eclampsia and induction of labour. ( 7111114 )
1982
50
Thyrotoxic crisis masked by treatment with beta-blockers. ( 6790119 )
1981

Variations for Thyroid Crisis

Expression for Thyroid Crisis

Search GEO for disease gene expression data for Thyroid Crisis.

Pathways for Thyroid Crisis

GO Terms for Thyroid Crisis

Cellular components related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB CTSH F8 POMC PTH SERPINA7
2 extracellular region GO:0005576 9.23 ALB CTSH F8 POMC PTH SERPINA7

Biological processes related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB CTSH TTR
2 regulation of signaling receptor activity GO:0010469 9.26 POMC PTH TG TTR
3 thyroid gland development GO:0030878 9.16 TG THRB
4 thyroid hormone transport GO:0070327 8.62 SERPINA7 TTR

Molecular functions related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.26 POMC PTH TG TTR
2 oxygen binding GO:0019825 9.16 ALB MB
3 thyroid hormone binding GO:0070324 8.8 CTSH THRB TTR

Sources for Thyroid Crisis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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