MCID: THY001
MIFTS: 29

Thyroid Crisis

Categories: Endocrine diseases

Aliases & Classifications for Thyroid Crisis

MalaCards integrated aliases for Thyroid Crisis:

Name: Thyroid Crisis 12 44 15 73
Thyrotoxic Crisis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12837
MeSH 44 D013958
NCIt 50 C112836
SNOMED-CT 68 190262002 29028009
UMLS 73 C0040127

Summaries for Thyroid Crisis

MalaCards based summary : Thyroid Crisis, also known as thyrotoxic crisis, is related to acute thyroiditis and thyroiditis. An important gene associated with Thyroid Crisis is CTSH (Cathepsin H). The drugs Antithyroid Agents and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and testes.

Wikipedia : 76 Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the... more...

Related Diseases for Thyroid Crisis

Diseases related to Thyroid Crisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 acute thyroiditis 29.3 POMC TG
2 thyroiditis 10.5
3 toxic myocarditis 10.3 KANTR ZIC3
4 cerebral arteritis 10.2 F8 KANTR
5 sella turcica neoplasm 10.2 F8 POMC
6 lateral medullary syndrome 10.2 CR1 KANTR
7 tuberculum sellae meningioma 10.2 F8 POMC
8 afibrinogenemia, congenital 10.2 CR1 F8
9 afibrinogenemia 10.2 CR1 F8
10 laryngeal tuberculosis 10.1 KANTR POMC
11 glossopharyngeal neuralgia 10.1 KANTR POMC
12 nodular nonsuppurative panniculitis 10.1 F8 POMC
13 shwartzman phenomenon 10.1 KANTR POMC
14 neurodermatitis 10.1 KANTR POMC
15 scleredema adultorum 10.1 POMC PTH
16 premenstrual tension 10.0 KANTR POMC
17 cloacogenic carcinoma 9.9 POMC PTH
18 hyperthyroidism 9.9
19 orthostatic intolerance 9.9 KANTR POMC
20 mineral metabolism disease 9.9 POMC PTH
21 hypoglycemia 9.9
22 organ system benign neoplasm 9.8 POMC PTH
23 endocrine exophthalmos 9.8 POMC TG
24 cell type benign neoplasm 9.8 POMC PTH
25 hypoadrenalism 9.8 POMC TG
26 hypothyroidism 9.8
27 urinary system disease 9.8 POMC PTH
28 hypothyroidism, congenital, nongoitrous, 4 9.8 POMC TG
29 hypertropia 9.7 KANTR TG
30 postsurgical hypothyroidism 9.7 PTH TG
31 water-clear cell adenoma 9.7 PTH TG
32 clear cell adenoma 9.7 PTH TG
33 acquired metabolic disease 9.7 POMC PTH
34 schizophrenia 9.6
35 acth deficiency, isolated 9.6
36 asthma 9.6
37 stroke, ischemic 9.6
38 burns 9.6
39 congestive heart failure 9.6
40 interstitial nephritis 9.6
41 disseminated intravascular coagulation 9.6
42 heart disease 9.6
43 graves' disease 9.6
44 acute kidney tubular necrosis 9.6
45 cerebritis 9.6
46 lactic acidosis 9.6
47 malignant hyperthermia 9.6
48 duodenitis 9.6
49 west syndrome 9.6 KANTR POMC
50 immune system disease 9.6 F8 TG

Graphical network of the top 20 diseases related to Thyroid Crisis:



Diseases related to Thyroid Crisis

Symptoms & Phenotypes for Thyroid Crisis

Drugs & Therapeutics for Thyroid Crisis

Drugs for Thyroid Crisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antithyroid Agents Phase 4
2 Hormone Antagonists Phase 4
3 Hormones Phase 4
4 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
2 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole

Search NIH Clinical Center for Thyroid Crisis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: thyroid crisis

Genetic Tests for Thyroid Crisis

Anatomical Context for Thyroid Crisis

MalaCards organs/tissues related to Thyroid Crisis:

41
Thyroid, Heart, Testes, Liver

Publications for Thyroid Crisis

Articles related to Thyroid Crisis:

(show top 50) (show all 70)
# Title Authors Year
1
Thyroid Crisis in a Patient With Burn Injury. ( 28157789 )
2017
2
Propranolol-Induced Circulatory Collapse in a Patient With Thyroid Crisis and Underlying Thyrocardiac Disease: A Word of Caution. ( 29318163 )
2017
3
Out of the blue! Thyroid crisis. ( 25886440 )
2015
4
Acute severe asthma with thyroid crisis and myasthenia: A case report and literature review. ( 26471346 )
2015
5
Thyroid Crisis in the Maxillofacial Trauma Patient. ( 25085805 )
2014
6
Successful treatment of thyroid crisis accompanied by hypoglycemia, lactic acidosis, and multiple organ failure. ( 22386356 )
2012
7
Severe hypoglycemia accompanied with thyroid crisis. ( 23198181 )
2012
8
Isolated adrenocorticotropic hormone deficiency associated with Hashimoto's disease and thyroid crisis triggered by head trauma. Case report. ( 22278027 )
2012
9
Severe duodenal hemorrhage induced by Lugol's solution administered for thyroid crisis treatment. ( 20424366 )
2010
10
Thyroid crisis following interstitial nephritis. ( 18591847 )
2008
11
Utility of esmolol in thyroid crisis. ( 17127774 )
2006
12
Severe starvation hypoglycemia and congestive heart failure induced by thyroid crisis, with accidentally induced severe liver dysfunction and disseminated intravascular coagulation. ( 15805713 )
2005
13
Storm in a T-CUP: thyroid crisis following trauma. ( 14636743 )
2003
14
Fatal thyroid crisis years after two thyroidectomies for graves' disease: is thyroid tissue autotransplantation for postthyroidectomy hypothyroidism worthwhile? ( 12229955 )
2002
15
Differential diagnosis of thyroid crisis and malignant hyperthermia in an anesthetized porcine model. ( 10098596 )
1999
16
Dantrolene and thyroid crisis. ( 7865016 )
1994
17
Recognizing thyroid crisis. ( 8265033 )
1993
18
A case of thyroid crisis occurring during surgery. ( 15278567 )
1992
19
Rhabdomyolysis accompanying thyroid crisis: an autopsy case report. ( 1286234 )
1992
20
Thyroid crisis associated with severe hypocalcemia. ( 1865592 )
1991
21
Hyperthyroidism: thyroid crisis (storm, thyrotoxic crisis). ( 2668603 )
1989
22
Acute thyroid crisis on induction of anaesthesia. ( 2929904 )
1989
23
Thyroid crisis complicated by cerebral infarction. ( 3689644 )
1987
24
Thyroid crisis. ( 3670755 )
1987
25
Thyroid crisis presenting as coma. ( 6096063 )
1984
26
Thyroid crisis. ( 469283 )
1979
27
Clinical analysis of 36 episodes of thyroid crisis. ( 95932 )
1978
28
Thyroid crisis and tracheal compression in patient with retrosternal goitre. ( 709205 )
1978
29
Thyroid crisis diagnostic criteria, thyroid function tests and treatment. ( 577315 )
1977
30
Case reports. Hyperthyroidism in the presence of panhypopituitarism. Thyroid crisis and hypothyroidism following radioiodine treatment. ( 4846511 )
1974
31
Thyroid crisis following abdominal surgery. ( 4845569 )
1974
32
Thyroid crisis complicating thyrotoxicosis. ( 4128114 )
1973
33
Thyroid crisis: A case report and current treatment. ( 4518782 )
1973
34
Thyroid crisis today. ( 5560334 )
1971
35
Fever in thyroid crisis. ( 5540486 )
1971
36
Thyroid crisis induced by radioactive iodine. ( 5580842 )
1971
37
Monoclonal gammopathy, thyroid crisis and congenital heart disease in a patient with trisomy syndrome (Down's syndrome or mongolism). ( 4190010 )
1970
38
Thyroid crisis after extrathyroid surgery in previously unrecognised hyperthyroidism. A report of 2 cases. ( 5493204 )
1970
39
The treatment of thyroid crisis. ( 4192435 )
1970
40
Thyroid crisis: diagnosis and treatment. ( 5796710 )
1969
41
Acute thyroiditis, thyroid crisis, and hypocalcemia following radioactive iodine therapy. ( 5256185 )
1969
42
Thyroid crisis and the law. ( 5819463 )
1969
43
Thyroid crisis in a county hospital. ( 5259828 )
1969
44
Thyroid crisis and the law. ( 5818574 )
1969
45
Treatment of thyroid crisis by beta-adrenergic blockade. ( 4171013 )
1968
46
Schizophrenia-like psychosis in thyroid crisis. ( 4178468 )
1968
47
Thyroid crisis in a 3-year-old girl. ( 5694233 )
1968
48
Hibernation in thyroid crisis. ( 5852497 )
1965
49
BIOCHEMICAL BASIS OF THYROID CRISIS. ( 14281917 )
1965
50
Severe thyrotoxicosis (thyroid crisis). ( 5848159 )
1965

Variations for Thyroid Crisis

Expression for Thyroid Crisis

Search GEO for disease gene expression data for Thyroid Crisis.

Pathways for Thyroid Crisis

GO Terms for Thyroid Crisis

Cellular components related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CTSH F8 POMC PTH TG
2 extracellular space GO:0005615 9.02 CTSH F8 POMC PTH TG

Biological processes related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 8.8 POMC PTH TG

Molecular functions related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 POMC PTH TG

Sources for Thyroid Crisis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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