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MCID: THY001
MIFTS: 33

Thyroid Crisis

Categories: Endocrine diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Thyroid Crisis

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MalaCards integrated aliases for Thyroid Crisis:

Name: Thyroid Crisis 12 44 15 73
Thyrotoxic Crisis 12

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:12837
MeSH 44 D013958
NCIt 50 C112836
SNOMED-CT 68 29028009
UMLS 73 C0040127
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Summaries for Thyroid Crisis

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MalaCards based summary : Thyroid Crisis, also known as thyrotoxic crisis, is related to subacute thyroiditis and hyperthyroidism. An important gene associated with Thyroid Crisis is SERPINA7 (Serpin Family A Member 7), and among its related pathways/superpathways is Aldosterone synthesis and secretion. The drugs Methimazole and Antithyroid Agents have been mentioned in the context of this disorder. Affiliated tissues include thyroid, heart and skin.

Wikipedia : 76 Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the... more...

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Related Diseases for Thyroid Crisis

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Diseases related to Thyroid Crisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 subacute thyroiditis 30.3 SERPINA7 TG
2 hyperthyroidism 30.3 SERPINA7 TG THRB
3 acute thyroiditis 29.9 POMC TG
4 thyroiditis 29.8 SERPINA7 TG THRB
5 graves' disease 29.8 SERPINA7 TG THRB
6 acute kidney tubular necrosis 29.5 ALB MB
7 hypothyroidism 29.5 POMC SERPINA7 TG THRB TTR
8 dyshormonogenic goiter 10.3 SERPINA7 TG
9 hypothyroidism, congenital, nongoitrous, 2 10.3 SERPINA7 TG
10 nontoxic goiter 10.2 SERPINA7 TG
11 toxic diffuse goiter 10.2 SERPINA7 TG
12 plummer's disease 10.2 TG THRB
13 postsurgical hypothyroidism 10.2 MB TG
14 endocrine exophthalmos 10.2 POMC TG
15 hypoadrenalism 10.2 POMC TG
16 opportunistic bacterial infectious disease 10.2 POMC ZIC3
17 nocardiosis 10.2 POMC ZIC3
18 goiter 10.2 SERPINA7 TG THRB
19 water-clear cell adenoma 10.2 PTH TG
20 clear cell adenoma 10.2 PTH TG
21 graves disease 1 10.2 SERPINA7 TG THRB
22 thyroid hormone resistance, generalized, autosomal dominant 10.2 SERPINA7 TG THRB
23 autoimmune disease of endocrine system 10.2 SERPINA7 TG
24 cerebral arteritis 10.1 F8 KANTR
25 toxic myocarditis 10.1 KANTR ZIC3
26 amyloid tumor 10.1 TG TTR
27 pericardium cancer 10.1 F8 MB
28 posterior myocardial infarction 10.1 KANTR MB
29 scleredema adultorum 10.1 POMC PTH
30 chromophobe adenoma 10.1 POMC SERPINA7
31 subendocardial myocardial infarction 10.1 KANTR MB
32 hypothyroidism, congenital, nongoitrous, 4 10.1 POMC SERPINA7 TG
33 myxedema 10.1
34 diabetes mellitus, ketosis-prone 10.1
35 visual agnosia 10.1 KANTR MB
36 lateral medullary syndrome 10.1 CR1 KANTR
37 glossopharyngeal neuralgia 10.1 KANTR POMC
38 endemic goiter 10.1 PTH SERPINA7 TG
39 laryngeal tuberculosis 10.1 KANTR POMC
40 thyroid cancer, nonmedullary, 2 10.1 POMC TG THRB
41 thymus lipoma 10.1 MB PTH
42 cardiovascular organ benign neoplasm 10.1 KANTR MB
43 abducens nerve disease 10.1 KANTR POMC
44 benign perivascular tumor 10.1 KANTR MB
45 tibial neuropathy 10.1 POMC TTR
46 tarsal tunnel syndrome 10.1 POMC TTR
47 cloacogenic carcinoma 10.0 POMC PTH
48 tsh producing pituitary tumor 10.0 POMC TTR
49 neurodermatitis 10.0 KANTR POMC
50 fournier gangrene 10.0 ALB F8

Graphical network of the top 20 diseases related to Thyroid Crisis:



Diseases related to Thyroid Crisis
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Symptoms & Phenotypes for Thyroid Crisis

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Drugs & Therapeutics for Thyroid Crisis

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Drugs for Thyroid Crisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methimazole Approved Phase 4 60-56-0 1349907
2 Antithyroid Agents Phase 4
3 Hormones Phase 4
4 Hormone Antagonists Phase 4
5 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
2 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole

Search NIH Clinical Center for Thyroid Crisis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: thyroid crisis

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Genetic Tests for Thyroid Crisis

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Anatomical Context for Thyroid Crisis

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MalaCards organs/tissues related to Thyroid Crisis:

41
Thyroid, Heart, Skin, Kidney, Pituitary, Pancreas, Thymus
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Publications for Thyroid Crisis

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Articles related to Thyroid Crisis:

(show top 50) (show all 114)
# Title Authors Year
1
Diltiazem-Associated Cardiogenic Shock in Thyrotoxic Crisis. ( 29521654 )
2018
2
Thyrotoxic crisis as an acute clinical presentation in a child. ( 29574428 )
2018
3
Thyroid Crisis in a Patient With Burn Injury. ( 28157789 )
2017
4
Propranolol-Induced Circulatory Collapse in a Patient With Thyroid Crisis and Underlying Thyrocardiac Disease: A Word of Caution. ( 29318163 )
2017
5
Cardiac arrest caused by landiolol in a patient in thyroid crisis. ( 30546666 )
2016
6
Thyrotoxic crisis presenting with jaundice. ( 27338936 )
2016
7
Jaundice Heralding the Onset of Thyrotoxic Crisis. ( 27762123 )
2016
8
Out of the blue! Thyroid crisis. ( 25886440 )
2015
9
Acute severe asthma with thyroid crisis and myasthenia: A case report and literature review. ( 26471346 )
2015
10
Trauma triggering thyrotoxic crisis with lactic acidosis. ( 26604530 )
2015
11
Onset of reversible flaccid quadriplegia during treatment of thyrotoxic crisis. ( 25748960 )
2015
12
Thyroid Crisis in the Maxillofacial Trauma Patient. ( 25085805 )
2014
13
Successful treatment of thyroid crisis accompanied by hypoglycemia, lactic acidosis, and multiple organ failure. ( 22386356 )
2012
14
Severe hypoglycemia accompanied with thyroid crisis. ( 23198181 )
2012
15
Isolated adrenocorticotropic hormone deficiency associated with Hashimoto's disease and thyroid crisis triggered by head trauma. Case report. ( 22278027 )
2012
16
Acute Cardiac Failure in a Pregnant Woman due to Thyrotoxic Crisis. ( 24804110 )
2012
17
Thyrotoxic crisis associated with gestational trophoblastic disease. ( 21920210 )
2011
18
Severe duodenal hemorrhage induced by Lugol's solution administered for thyroid crisis treatment. ( 20424366 )
2010
19
Treatment of thyrotoxic crisis with plasmapheresis and single pass albumin dialysis: a case report. ( 20420590 )
2010
20
Thyroid arterial embolization for the treatment of hyperthyroidism in a patient with thyrotoxic crisis. ( 19178883 )
2009
21
Thyroid crisis following interstitial nephritis. ( 18591847 )
2008
22
Successful treatment of gastric perforation with thyrotoxic crisis. ( 19091282 )
2008
23
Utility of esmolol in thyroid crisis. ( 17127774 )
2006
24
Severe starvation hypoglycemia and congestive heart failure induced by thyroid crisis, with accidentally induced severe liver dysfunction and disseminated intravascular coagulation. ( 15805713 )
2005
25
Thyrotoxic crisis induced by cytotoxic chemotherapy. ( 15459765 )
2005
26
Management of thyrotoxic crisis. ( 15850146 )
2005
27
Storm in a T-CUP: thyroid crisis following trauma. ( 14636743 )
2003
28
Fatal thyroid crisis years after two thyroidectomies for graves' disease: is thyroid tissue autotransplantation for postthyroidectomy hypothyroidism worthwhile? ( 12229955 )
2002
29
Differential diagnosis of thyroid crisis and malignant hyperthermia in an anesthetized porcine model. ( 10098596 )
1999
30
Thyrotoxic crisis presenting as acute abdomen. ( 9496295 )
1997
31
Dantrolene and thyroid crisis. ( 7865016 )
1994
32
Reversible neurological complications during thyrotoxic crisis. ( 7868528 )
1994
33
Recognizing thyroid crisis. ( 8265033 )
1993
34
A case of thyroid crisis occurring during surgery. ( 15278567 )
1992
35
Rhabdomyolysis accompanying thyroid crisis: an autopsy case report. ( 1286234 )
1992
36
Thyroid crisis associated with severe hypocalcemia. ( 1865592 )
1991
37
Emergency department management of thyrotoxic crisis with esmolol. ( 1673341 )
1991
38
Thyrotoxic crisis in Graves' disease: indication for immediate surgery. ( 1707465 )
1990
39
Thyrotoxic crisis presenting as status epilepticus. ( 2349191 )
1990
40
Thyrotoxic crisis after emergency laparotomy. A case report. ( 2360122 )
1990
41
Hyperthyroidism: thyroid crisis (storm, thyrotoxic crisis). ( 2668603 )
1989
42
Acute thyroid crisis on induction of anaesthesia. ( 2929904 )
1989
43
Thyroid crisis complicated by cerebral infarction. ( 3689644 )
1987
44
Thyroid crisis. ( 3670755 )
1987
45
Fatal thyrotoxic crisis. ( 3755568 )
1986
46
Atrioventricular and sinoatrial block in thyrotoxic crisis. ( 4074593 )
1985
47
Thyroid crisis presenting as coma. ( 6096063 )
1984
48
Successful treatment of thyrotoxic crisis with plasma exchange. ( 6723341 )
1984
49
A case of thyrotoxic crisis that mimicked malignant hyperthermia. ( 6881599 )
1983
50
Thyrotoxic crisis following eclampsia and induction of labour. ( 7111114 )
1982
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Variations for Thyroid Crisis

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Expression for Thyroid Crisis

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Search GEO for disease gene expression data for Thyroid Crisis.
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Pathways for Thyroid Crisis

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Pathways related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 37
Show member pathways
 11.7 ALB POMC SERPINA7 TG TTR
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GO Terms for Thyroid Crisis

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Cellular components related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB CTSH F8 POMC PTH SERPINA7
2 extracellular region GO:0005576 9.23 ALB CTSH F8 POMC PTH SERPINA7

Biological processes related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB CTSH TTR
2 regulation of signaling receptor activity GO:0010469 9.26 POMC PTH TG TTR
3 thyroid gland development GO:0030878 9.16 TG THRB
4 thyroid hormone transport GO:0070327 8.62 SERPINA7 TTR

Molecular functions related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.26 POMC PTH TG TTR
2 oxygen binding GO:0019825 9.16 ALB MB
3 thyroid hormone binding GO:0070324 8.8 CTSH THRB TTR
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Sources for Thyroid Crisis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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