MCID: THY001
MIFTS: 37

Thyroid Crisis

Categories: Endocrine diseases

Aliases & Classifications for Thyroid Crisis

MalaCards integrated aliases for Thyroid Crisis:

Name: Thyroid Crisis 12 45 15 17 74
Thyrotoxic Crisis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12837
MeSH 45 D013958
NCIt 51 C112836
SNOMED-CT 69 29028009
UMLS 74 C0040127

Summaries for Thyroid Crisis

MalaCards based summary : Thyroid Crisis, also known as thyrotoxic crisis, is related to subacute thyroiditis and hyperthyroidism. An important gene associated with Thyroid Crisis is SERPINA7 (Serpin Family A Member 7), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Transcription_Role of VDR in regulation of genes involved in osteoporosis. The drugs Methimazole and Hormone Antagonists have been mentioned in the context of this disorder. Affiliated tissues include thyroid, kidney and pituitary, and related phenotype is homeostasis/metabolism.

Wikipedia : 77 Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the... more...

Related Diseases for Thyroid Crisis

Diseases related to Thyroid Crisis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 subacute thyroiditis 30.5 SERPINA7 TG
2 hyperthyroidism 30.3 SERPINA7 TG THRB
3 graves disease 1 30.1 SERPINA7 TG THRB
4 acute thyroiditis 30.0 POMC TG
5 goiter 29.9 SERPINA7 TG THRB
6 thyroiditis 29.9 SERPINA7 TG THRB
7 acute kidney tubular necrosis 29.5 ALB MB
8 burns 29.4 ALB TTR
9 hypothyroidism 29.2 POMC SERPINA7 TG THRB TTR
10 dyshormonogenic goiter 10.4 SERPINA7 TG
11 hypothyroidism, congenital, nongoitrous, 2 10.4 SERPINA7 TG
12 nontoxic goiter 10.3 SERPINA7 TG
13 toxic diffuse goiter 10.3 SERPINA7 TG
14 plummer's disease 10.3 TG THRB
15 postsurgical hypothyroidism 10.3 MB TG
16 endocrine exophthalmos 10.3 POMC TG
17 hypoadrenalism 10.3 POMC TG
18 autoimmune disease of endocrine system 10.3 SERPINA7 TG
19 water-clear cell adenoma 10.2 PTH TG
20 clear cell adenoma 10.2 PTH TG
21 cerebral arteritis 10.2 F8 KANTR
22 pericardium cancer 10.2 F8 MB
23 thyroid hormone resistance, generalized, autosomal dominant 10.2 SERPINA7 TG THRB
24 chromophobe adenoma 10.2 POMC SERPINA7
25 posterior myocardial infarction 10.2 KANTR MB
26 subendocardial myocardial infarction 10.2 KANTR MB
27 scleredema adultorum 10.2 POMC PTH
28 amyloid tumor 10.2 TG TTR
29 visual agnosia 10.2 KANTR MB
30 glossopharyngeal neuralgia 10.1 KANTR POMC
31 thymus lipoma 10.1 MB PTH
32 laryngeal tuberculosis 10.1 KANTR POMC
33 hypothyroidism, congenital, nongoitrous, 4 10.1 POMC SERPINA7 TG
34 cardiovascular organ benign neoplasm 10.1 KANTR MB
35 benign perivascular tumor 10.1 KANTR MB
36 myxedema 10.1
37 diabetes mellitus, ketosis-prone 10.1
38 abducens nerve disease 10.1 KANTR POMC
39 nodular nonsuppurative panniculitis 10.1 F8 POMC
40 tibial neuropathy 10.1 POMC TTR
41 tarsal tunnel syndrome 10.1 POMC TTR
42 endemic goiter 10.1 PTH SERPINA7 TG
43 cloacogenic carcinoma 10.1 POMC PTH
44 thyroid cancer, nonmedullary, 2 10.1 POMC TG THRB
45 neurodermatitis 10.1 KANTR POMC
46 premenstrual tension 10.1 KANTR POMC
47 tsh producing pituitary tumor 10.1 POMC TTR
48 fournier gangrene 10.0 ALB F8
49 brown-sequard syndrome 10.0 KANTR TTR
50 noma 10.0 ALB POMC

Graphical network of the top 20 diseases related to Thyroid Crisis:



Diseases related to Thyroid Crisis

Symptoms & Phenotypes for Thyroid Crisis

MGI Mouse Phenotypes related to Thyroid Crisis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.23 ALB F8 MB POMC PTH TG

Drugs & Therapeutics for Thyroid Crisis

Drugs for Thyroid Crisis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methimazole Approved Phase 4 60-56-0 1349907
2 Hormone Antagonists Phase 4
3 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
4 Hormones Phase 4
5 Antithyroid Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
2 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole

Search NIH Clinical Center for Thyroid Crisis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: thyroid crisis

Genetic Tests for Thyroid Crisis

Anatomical Context for Thyroid Crisis

MalaCards organs/tissues related to Thyroid Crisis:

42
Thyroid, Kidney, Pituitary, Testes, Skin, Thymus

Publications for Thyroid Crisis

Articles related to Thyroid Crisis:

(show top 50) (show all 123)
# Title Authors Year
1
A rare complication of bedside tracheotomy: Thyroid crisis. ( 30604713 )
2019
2
Diltiazem-Associated Cardiogenic Shock in Thyrotoxic Crisis. ( 29521654 )
2018
3
Thyrotoxic crisis as an acute clinical presentation in a child. ( 29574428 )
2018
4
Subacute thyroiditis causing thyrotoxic crisis; a case report with literature review. ( 28399492 )
2017
5
Acute severe asthma with thyroid crisis and myasthenia: a case report and literature review. ( 26471346 )
2017
6
Thyroid Crisis in a Patient With Burn Injury. ( 28157789 )
2017
7
Propranolol-Induced Circulatory Collapse in a Patient With Thyroid Crisis and Underlying Thyrocardiac Disease: A Word of Caution. ( 29318163 )
2017
8
Cardiac arrest caused by landiolol in a patient in thyroid crisis. ( 30546666 )
2016
9
Thyrotoxic crisis presenting with jaundice. ( 27338936 )
2016
10
Jaundice Heralding the Onset of Thyrotoxic Crisis. ( 27762123 )
2016
11
Trauma triggering thyrotoxic crisis with lactic acidosis. ( 26604530 )
2015
12
Onset of reversible flaccid quadriplegia during treatment of thyrotoxic crisis. ( 25748960 )
2015
13
Out of the blue! Thyroid crisis. ( 25886440 )
2015
14
Acute pericarditis: unique comorbidity of thyrotoxic crisis with Graves' disease. ( 24411211 )
2014
15
Thyroid crisis in the maxillofacial trauma patient. ( 25085805 )
2014
16
Maximinus Daia, a Roman emperor who may have had Graves' disease and died of a thyrotoxic crisis. ( 23624140 )
2013
17
Successful treatment of thyrotoxic crisis after esophagectomy in an elderly woman with hyperthyroidism. ( 22632530 )
2012
18
Severe hypoglycemia accompanied with thyroid crisis. ( 23198181 )
2012
19
Successful treatment of thyroid crisis accompanied by hypoglycemia, lactic acidosis, and multiple organ failure. ( 22386356 )
2012
20
Isolated adrenocorticotropic hormone deficiency associated with Hashimoto's disease and thyroid crisis triggered by head trauma. Case report. ( 22278027 )
2012
21
Acute Cardiac Failure in a Pregnant Woman due to Thyrotoxic Crisis. ( 24804110 )
2012
22
Thyrotoxic crisis associated with gestational trophoblastic disease. ( 21920210 )
2011
23
Severe duodenal hemorrhage induced by Lugol's solution administered for thyroid crisis treatment. ( 20424366 )
2010
24
Treatment of thyrotoxic crisis with plasmapheresis and single pass albumin dialysis: a case report. ( 20420590 )
2010
25
Thyroid arterial embolization for the treatment of hyperthyroidism in a patient with thyrotoxic crisis. ( 19178883 )
2009
26
Thyroid crisis following interstitial nephritis. ( 18591847 )
2008
27
Acute suppurative thyroiditis with abscess, gas formation, and thyrotoxic crisis. ( 18763371 )
2008
28
Successful treatment of gastric perforation with thyrotoxic crisis. ( 19091282 )
2008
29
Utility of esmolol in thyroid crisis. ( 17127774 )
2006
30
Severe starvation hypoglycemia and congestive heart failure induced by thyroid crisis, with accidentally induced severe liver dysfunction and disseminated intravascular coagulation. ( 15805713 )
2005
31
Thyrotoxic crisis induced by cytotoxic chemotherapy. ( 15459765 )
2005
32
Management of thyrotoxic crisis. ( 15850146 )
2005
33
Storm in a T-CUP: thyroid crisis following trauma. ( 14636743 )
2003
34
Fatal thyroid crisis years after two thyroidectomies for graves' disease: is thyroid tissue autotransplantation for postthyroidectomy hypothyroidism worthwhile? ( 12229955 )
2002
35
McCune-Albright syndrome associated with non-autoimmune type of hyperthyroidism with development of thyrotoxic crisis. ( 11150888 )
2000
36
Differential diagnosis of thyroid crisis and malignant hyperthermia in an anesthetized porcine model. ( 10098596 )
1999
37
Thyrotoxic crisis presenting as acute abdomen. ( 9496295 )
1997
38
Dantrolene and thyroid crisis. ( 7865016 )
1994
39
Reversible neurological complications during thyrotoxic crisis. ( 7868528 )
1994
40
Recognizing thyroid crisis. ( 8265033 )
1993
41
Rhabdomyolysis accompanying thyroid crisis: an autopsy case report. ( 1286234 )
1992
42
A case of thyroid crisis occurring during surgery. ( 15278567 )
1992
43
Thyroid crisis associated with severe hypocalcemia. ( 1865592 )
1991
44
Emergency department management of thyrotoxic crisis with esmolol. ( 1673341 )
1991
45
Thyrotoxic crisis in Graves' disease: indication for immediate surgery. ( 1707465 )
1990
46
Thyrotoxic crisis presenting as status epilepticus. ( 2349191 )
1990
47
Thyrotoxic crisis after emergency laparotomy. A case report. ( 2360122 )
1990
48
Hyperthyroidism: thyroid crisis (storm, thyrotoxic crisis). ( 2668603 )
1989
49
Acute thyroid crisis on induction of anaesthesia. ( 2929904 )
1989
50
Thyroid crisis. ( 3670755 )
1987

Variations for Thyroid Crisis

Expression for Thyroid Crisis

Search GEO for disease gene expression data for Thyroid Crisis.

Pathways for Thyroid Crisis

GO Terms for Thyroid Crisis

Cellular components related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 ALB CTSH F8 POMC PTH SERPINA7
2 extracellular region GO:0005576 9.23 ALB CTSH F8 POMC PTH SERPINA7

Biological processes related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.43 ALB CTSH TTR
2 regulation of signaling receptor activity GO:0010469 9.26 POMC PTH TG TTR
3 thyroid gland development GO:0030878 9.16 TG THRB
4 thyroid hormone transport GO:0070327 8.62 SERPINA7 TTR

Molecular functions related to Thyroid Crisis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.26 POMC PTH TG TTR
2 oxygen binding GO:0019825 9.16 ALB MB
3 thyroid hormone binding GO:0070324 8.8 CTSH THRB TTR

Sources for Thyroid Crisis

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7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
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45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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