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MCID: THY030
MIFTS: 50

Thyroid Gland Disease

Categories: Endocrine diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Thyroid Gland Disease

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MalaCards integrated aliases for Thyroid Gland Disease:

Name: Thyroid Gland Disease 12 15
Abnormality of the Thyroid Gland 30 6
Thyroid Diseases 45 74

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:50
MeSH 45 D013959
NCIt 51 C26893
SNOMED-CT 69 14304000
ICD10 34 E00-E07 E07.9
UMLS 74 C0040128
Sources

Summaries for Thyroid Gland Disease

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Disease Ontology : 12 An endocrine system disease that is located in the thyroid.

MalaCards based summary : Thyroid Gland Disease, also known as abnormality of the thyroid gland, is related to hyperthyroxinemia and hyperthyroidism. An important gene associated with Thyroid Gland Disease is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Iodine and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, eye and testes, and related phenotypes are no effect and endocrine/exocrine gland

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Related Diseases for Thyroid Gland Disease

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Diseases related to Thyroid Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 297)
# Related Disease Score Top Affiliating Genes
1 hyperthyroxinemia 32.3 SERPINA7 TPO TRH TSHR
2 hyperthyroidism 31.9 SERPINA7 TG THRB TPO TRH TSHR
3 graves disease 1 31.6 DIO2 SERPINA7 TG THRB TPO TRH
4 goiter 31.1 CALCA NKX2-1 PAX8 SERPINA7 SLC26A4 SLC5A5
5 thyroid cancer 30.9 CALCA DIO2 FOXE1 NCOA4 NKX2-1 PAX8
6 hypothyroidism 30.6 CALCA DIO2 FOXE1 NKX2-1 PAX8 RET
7 graves' disease 30.6 DIO2 SERPINA7 TG TPO TSHR
8 myxedema 30.6 TG TPO TSHR
9 thyroid carcinoma, familial medullary 30.5 CALCA NKX2-1 RET TG
10 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.5 TG TPO TSHR
11 hashimoto thyroiditis 30.4 CALCA RET SLC26A4 TG TPO TSHB
12 thyroiditis 30.2 CALCA RET SERPINA7 TG THRB TPO
13 nodular goiter 30.2 CALCA RET SLC5A5 TG TPO TSHR
14 primary hyperparathyroidism 30.2 CALCA PTH RET
15 hyperparathyroidism 30.2 CALCA PTH RET
16 subacute thyroiditis 30.1 SERPINA7 TG TPO TSHR
17 parathyroid adenoma 29.9 CALCA PTH RET
18 endemic goiter 29.8 PTH SERPINA7 TG TPO TSHB TSHR
19 multinodular goiter 29.8 CALCA NKX2-1 PAX8 SLC26A4 TG TPO
20 papillary carcinoma 29.8 CALCA NCOA4 NKX2-1 PAX8 RET TG
21 pendred syndrome 29.8 PAX8 SLC26A4 TG TPO
22 hypothyroidism, congenital, nongoitrous, 4 29.7 SERPINA7 TG TPO TRH TSHB
23 differentiated thyroid carcinoma 29.5 FOXE1 NCOA4 NKX2-1 PAX8 RET TG
24 congenital hypothyroidism 29.4 FOXE1 NKX2-1 PAX8 SERPINA7 SLC26A4 SLC5A5
25 follicular adenoma 29.3 CALCA NKX2-1 PAX8 RET SLC26A4 TG
26 autoimmune thyroid disease 3 12.5
27 igg4-related thyroid disease 12.1
28 autoimmune thyroid disease 1 12.1
29 autoimmune thyroid disease 2 12.1
30 autoimmune thyroid disease 4 12.1
31 autoimmune polyendocrine syndrome, type ii 11.7
32 vitiligo-associated multiple autoimmune disease susceptibility 1 11.2
33 carpal tunnel syndrome 11.2
34 candidiasis, familial, 1 11.0
35 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.8
36 cholangitis, primary sclerosing 10.8
37 mthfr gene variant 10.8
38 clear cell adenoma 10.5 PTH TG
39 mucoepidermoid thyroid carcinoma 10.5 CALCA TG
40 subacute lymphocytic thyroiditis 10.5 TG TPO
41 hashimoto encephalopathy 10.5 TPO TSHR
42 benign struma ovarii 10.5 RET TG TSHR
43 suppurative thyroiditis 10.5 CALCA TG
44 thyroid sarcoma 10.5 CALCA TG
45 ovarian germ cell teratoma 10.5 NKX2-1 RET TG
46 familial thyroid dyshormonogenesis 10.5 SLC5A5 TG TPO
47 postsurgical hypothyroidism 10.5 TG TRH TSHR
48 substernal goiter 10.5 PTH TG
49 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.5 TG TPO
50 plummer's disease 10.5 TG THRB TPO

Comorbidity relations with Thyroid Gland Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential Hypothyroidism

Graphical network of the top 20 diseases related to Thyroid Gland Disease:



Diseases related to Thyroid Gland Disease
Sources

Symptoms & Phenotypes for Thyroid Gland Disease

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GenomeRNAi Phenotypes related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 CALCA DIO2 FOXE1 HIST2H2AA3 NCOA4 NKX2-1

MGI Mouse Phenotypes related to Thyroid Gland Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.18 DIO2 FOXE1 NKX2-1 PAX8 PTH RET
2 homeostasis/metabolism MP:0005376 10.13 DIO2 FOXE1 NCOA4 NKX2-1 PAX8 PTH
3 growth/size/body region MP:0005378 10.1 DIO2 FOXE1 NKX2-1 PAX8 PTH RET
4 digestive/alimentary MP:0005381 9.95 DIO2 FOXE1 NKX2-1 RET SLC26A4 TG
5 limbs/digits/tail MP:0005371 9.7 PAX8 PTH RET TG THRB TPO
6 no phenotypic analysis MP:0003012 9.5 NKX2-1 PAX8 RET THRB TPCN1 TRH
7 skeleton MP:0005390 9.28 DIO2 NKX2-1 PAX8 PTH SLC26A4 TG
Sources

Drugs & Therapeutics for Thyroid Gland Disease

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Drugs for Thyroid Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 883)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 7553-56-2 807
2
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 5311068 68602
3
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
4
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
5
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 7782-49-2
6
Methimazole Approved Phase 4,Phase 2,Phase 1,Not Applicable 60-56-0 1349907
7
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
8
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
9
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
10
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
11
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068
12
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-52-5 657298
13
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
14
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
15
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865
16
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
17
Amiodarone Approved, Investigational Phase 4,Phase 3,Not Applicable 1951-25-3 2157
18
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1401-55-4
19
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
20
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 38916-34-6, 51110-01-1 53481605
21
Pasireotide Approved Phase 4,Phase 3,Phase 2 396091-73-9 9941444
22
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 83150-76-9 6400441 383414
23
lanreotide Approved Phase 4,Phase 1,Phase 2 108736-35-2
24
Sodium Citrate Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 68-04-2
25
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302-25-0
26
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
27
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2921-57-5
28
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
29
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
30
Testosterone Approved, Experimental, Investigational Phase 4,Phase 1,Not Applicable,Early Phase 1 58-22-0, 481-30-1 10204 6013
31
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 28014-46-2
32
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-28-2 5757
33
Dinoprost tromethamine Approved, Vet_approved Phase 4,Not Applicable 38562-01-5 5282415
34
Dinoprost Approved, Investigational Phase 4,Not Applicable 551-11-1 5283078
35
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 525-66-6 4946
36
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 2,Phase 3 198153-51-4 5360545
37
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
38
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
39
Hydroxocobalamin Approved Phase 4,Phase 2,Not Applicable 13422-51-0 15589840 11953898
40
Iron Approved, Experimental Phase 4,Phase 2,Phase 1,Not Applicable 7439-89-6, 15438-31-0 27284 23925
41
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
42
Ribavirin Approved Phase 4,Phase 2,Phase 3 36791-04-5 37542
43
Peginterferon alfa-2b Approved Phase 4,Phase 2,Phase 3 215647-85-1, 99210-65-8
44
Sunitinib Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 557795-19-4, 341031-54-7 5329102
45
Glucagon Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 16941-32-5
46
Liraglutide Approved Phase 4,Phase 3,Phase 2,Not Applicable 204656-20-2 44147092
47
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Not Applicable 103-90-2 1983
48
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9002-64-6
49
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 3 51-84-3 187
50
Lenvatinib Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 417716-92-8

Interventional clinical trials:

(show top 50) (show all 2000)
# Name Status NCT ID Phase Drugs
1 rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
2 Radiolabeled Molecules for Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
3 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
4 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
5 Etoricoxib for Postoperative Pain After Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
6 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
7 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4 Methimazole
8 Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery Unknown status NCT01189721 Phase 4 propofol, sevoflurane
9 Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
10 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
11 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
12 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Unknown status NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
13 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
14 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
15 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
16 Trial Evaluating Use of Arista in Total Thyroidectomy Unknown status NCT02568085 Phase 4
17 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
18 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
19 Thyroxine Titration Study Unknown status NCT00111735 Phase 4 Thyroxine
20 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
21 Pasireotide LAR and Pegvisomant Study in Acromegaly Unknown status NCT02668172 Phase 4 Pasireotide LAR 60 mg;Pegvisomant
22 Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity Unknown status NCT02524184 Phase 4 sildenafil;placebo
23 AMIOdarone vs. Catheter Ablation for Prevention of Recurrent Symptomatic Atrial Fibrillation Unknown status NCT02341105 Phase 4 Amiodarone
24 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
25 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
26 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
27 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
28 Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Completed NCT00858104 Phase 4
29 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4 Levothyroxine;Placebo
30 Quality of Life, Recombinant TSH (Thyrogen) and Thyroid Cancer Completed NCT00604318 Phase 4 rhTSH
31 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4 Thyrogen
32 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
33 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4 Levothyroxine;Placebo
34 99Tc-MDP for Thyroid-Associated Ophthalmopathy Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
35 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
36 A Comparison of Patch vs. Pill Estrogen Therapy on Testosterone Levels and Thyroid Tests in Menopausal Women Completed NCT00224094 Phase 4 Premarin® (oral) vs. Alora® (transdermal)
37 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
38 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4 Levothyroxine;Placebo
39 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
40 Thyroid Medication and Antidepressants for Treating Major Depression Completed NCT00208702 Phase 4 Triiodothyronine;Sertraline
41 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
42 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
43 Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial Completed NCT00520338 Phase 4 celecoxib
44 The Effect of Metformin Treatment on Thyroid Hormone Metabolism in Euthyroid Patients With Type 2 Diabetes Mellitus Completed NCT00463502 Phase 4 Metformin
45 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
46 The TRUST Study - Depression Substudy Completed NCT01853579 Phase 4 Levothyroxine;Placebo
47 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
48 Effects of N-acetylcysteine on Low T3 Syndrome Completed NCT01501110 Phase 4 N-acetylcysteine
49 Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia Completed NCT01308320 Phase 4 fentanyl citrate;saline
50 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)

Search NIH Clinical Center for Thyroid Gland Disease

Cochrane evidence based reviews: thyroid diseases

Sources

Genetic Tests for Thyroid Gland Disease

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Genetic tests related to Thyroid Gland Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Thyroid Gland 30
Sources

Anatomical Context for Thyroid Gland Disease

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MalaCards organs/tissues related to Thyroid Gland Disease:

42
Thyroid, Eye, Testes, Lymph Node, Brain, Ovary, T Cells

The Foundational Model of Anatomy Ontology organs/tissues related to Thyroid Gland Disease:

20
The Thyroid
Sources

Publications for Thyroid Gland Disease

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Articles related to Thyroid Gland Disease:

# Title Authors Year
1
Multi-immunoreaction-based dual-color capillary electrophoresis for enhanced diagnostic reliability of thyroid gland disease. ( 28645753 )
2017
2
Cost-of-Illness Trend of Thyroid Gland Disease in Korea. ( 25309782 )
2014
3
Modern concepts of preoperative preparation of patients with thyroid gland disease. ( 21879658 )
2011
4
Localized crossed hyperhidrosis and the coexistence of thyroid gland disease. ( 20536672 )
2010
5
Application of thermography for non-invasive diagnosis of thyroid gland disease. ( 18334410 )
2008
6
Methodology of the thyroid gland disease decision-making using profiling in steroid hormone pathway. ( 17081718 )
2007
7
[Classification of thyroid gland disease on the basis of selenium concentration in serum]. ( 18246662 )
2007
8
Indications for surgery in thyroid gland disease. ( 13612484 )
1958
Sources

Variations for Thyroid Gland Disease

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ClinVar genetic disease variations for Thyroid Gland Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 COL7A1 NM_000094.3(COL7A1): c.1442G> A (p.Arg481His) single nucleotide variant Likely pathogenic rs147040026 GRCh38 Chromosome 3, 48591738: 48591738
2 COL7A1 NM_000094.3(COL7A1): c.1442G> A (p.Arg481His) single nucleotide variant Likely pathogenic rs147040026 GRCh37 Chromosome 3, 48629171: 48629171
Sources

Expression for Thyroid Gland Disease

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Search GEO for disease gene expression data for Thyroid Gland Disease.
Sources

Pathways for Thyroid Gland Disease

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Pathways related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Aldosterone synthesis and secretion 38
Show member pathways
 12.42 PAX8 SERPINA7 SLC26A4 SLC5A5 TG TPO
2
G alpha (s) signalling events 67
11.72 CALCA PTH TSHB TSHR
3
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.38 PAX8 TSHB TSHR
4
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.15 CALCA PTH THRB
5
Amine-derived hormones 67
Show member pathways
 11.06 DIO2 SLC5A5 TPO TSHB
6
Hormone ligand-binding receptors 67
10.52 TSHB TSHR
7
Thyroxine (Thyroid Hormone) Production 1
9.8 SLC5A5 TG TPO TRH TSHR
Sources

GO Terms for Thyroid Gland Disease

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Cellular components related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 8.8 DIO2 PTH TXNRD2

Biological processes related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.91 FOXE1 NCOA4 NKX2-1 PAX8 RET
2 regulation of signaling receptor activity GO:0010469 9.85 CALCA PTH TG TRH TSHB
3 cell-cell signaling GO:0007267 9.77 CALCA PTH TRH TSHB TSHR
4 anatomical structure morphogenesis GO:0009653 9.7 FOXE1 PAX8 TSHB
5 adenylate cyclase-activating G protein-coupled receptor signaling pathway GO:0007189 9.67 CALCA PTH TSHR
6 hormone-mediated signaling pathway GO:0009755 9.56 THRB TRH TSHB TSHR
7 hormone biosynthetic process GO:0042446 9.5 DIO2 TG TPO
8 thyroid hormone metabolic process GO:0042403 9.48 DIO2 TG
9 cellular response to gonadotropin stimulus GO:0071371 9.43 PAX8 SLC5A5
10 thyroid-stimulating hormone signaling pathway GO:0038194 9.4 PAX8 TSHR
11 iodide transport GO:0015705 9.33 SLC26A4 SLC5A5 TG
12 thyroid hormone generation GO:0006590 9.26 DIO2 FOXE1 SLC5A5 TPO
13 response to pain GO:0048265 9.24 RET
14 thyroid gland development GO:0030878 9.02 FOXE1 NKX2-1 PAX8 TG THRB

Molecular functions related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
2 hormone activity GO:0005179 9.02 CALCA PTH TG TRH TSHB
3 thyroid-stimulating hormone receptor activity GO:0004996 8.96 PAX8 TSHR
Sources

Sources for Thyroid Gland Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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