MCID: THY030
MIFTS: 45

Thyroid Gland Disease

Categories: Endocrine diseases
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Aliases & Classifications for Thyroid Gland Disease

MalaCards integrated aliases for Thyroid Gland Disease:

Name: Thyroid Gland Disease 11 14
Abnormality of the Thyroid Gland 28 5
Thyroid Diseases 43 71

Classifications:



External Ids:

Disease Ontology 11 DOID:50
ICD9CM 34 246.9
MeSH 43 D013959
NCIt 49 C26893
SNOMED-CT 68 14304000
ICD10 31 E07.9
UMLS 71 C0040128

Summaries for Thyroid Gland Disease

Disease Ontology: 11 An endocrine system disease that is located in the thyroid.

MalaCards based summary: Thyroid Gland Disease, also known as abnormality of the thyroid gland, is related to hyperthyroxinemia and graves disease 1. An important gene associated with Thyroid Gland Disease is COL7A1 (Collagen Type VII Alpha 1 Chain), and among its related pathways/superpathways are Thyroid hormones production and peripheral downstream signaling effects and Cell differentiation - expanded index. The drugs Nitroprusside and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and eye, and related phenotype is no phenotypic analysis.

Related Diseases for Thyroid Gland Disease

Diseases related to Thyroid Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 616)
# Related Disease Score Top Affiliating Genes
1 hyperthyroxinemia 32.4 TSHR TPO SERPINA7
2 graves disease 1 32.3 TSHR TRH TPO TG SERPINA7 POMC
3 hyperthyroidism 32.3 TSHR TRH TPO TG SERPINA7 POMC
4 goiter 32.3 TSHR TRH TPO TG SERPINA7 RET
5 graves' disease 32.2 TSHR TPO TG SERPINA7 PAX8 ICOSLG
6 hypothyroidism 32.2 TSHR TRH TPO TG SERPINA7 RET
7 autoimmune disease 31.8 TSHR TPO TG INS ICOSLG
8 nodular goiter 31.8 TSHR TPO TG RET MIR199A1 CALCA
9 hypothyroidism, congenital, nongoitrous, 2 31.7 TSHR TG PAX8
10 adenoma 31.5 TSHR TRH TG RET POMC
11 subacute thyroiditis 31.4 TSHR TPO TG SERPINA7
12 plummer's disease 31.3 TSHR TPO TG SERPINA7 CALCA
13 congenital hypothyroidism 31.2 TSHR TRH TPO TG SERPINA7 PAX8
14 type 1 diabetes mellitus 31.2 TPO TG INS ICOSLG CALCA
15 graves ophthalmopathy 31.1 TSHR TG
16 thyroid carcinoma, familial medullary 31.1 TG RET CALCA
17 endemic goiter 31.1 TSHR TRH TPO TG SERPINA7 PAX8
18 celiac disease 1 31.1 TPO TG INS ICOSLG H2AC18
19 hypoparathyroidism 31.1 TPO RET INS CALCA
20 vitiligo-associated multiple autoimmune disease susceptibility 1 31.1 TPO TG POMC ICOSLG
21 pernicious anemia 31.0 TPO TG INS ICOSLG
22 myxedema 31.0 TSHR TPO TG SERPINA7 POMC INS
23 thyroid cancer, nonmedullary, 2 30.9 TSHR TG PAX8 CALCA
24 thyroid gland cancer 30.8 TSHR TPO TG RET POMC PAX8
25 multiple endocrine neoplasia 30.8 TG RET POMC CALCA
26 toxic diffuse goiter 30.8 TSHR TPO TG
27 turner syndrome 30.8 TPO TG SERPINA7 INS
28 thyroid lymphoma 30.7 TPO TG RET CALCA
29 autoimmune gastritis 30.7 TPO TG ICOSLG
30 thyroid gland medullary carcinoma 30.6 TG RET POMC PAX8 MIR9-1 MIR222
31 connective tissue disease 30.6 MIR9-1 MIR222 MIR221 MIR199A1 MIR146B MIR138-1
32 hypothyroidism, congenital, nongoitrous, 1 30.6 TSHR TG PAX8
33 skin disease 30.6 POMC MIR9-1 MIR221 MIR199A1 INS ICOSLG
34 postsurgical hypothyroidism 30.6 TSHR TPO TG
35 thyroid cancer, nonmedullary, 1 30.6 MIR222 MIR221 MIR146B MIR138-1
36 euthyroid sick syndrome 30.5 TRH TG SERPINA7 POMC
37 premature menopause 30.5 TPO TG POMC INS CALCA
38 acute thyroiditis 30.5 TPO TG SERPINA7 CALCA
39 thyroid crisis 30.5 TSHR TPO TG SERPINA7 POMC
40 lipid metabolism disorder 30.5 POMC MIR199A1 INS H2AC18
41 goiter, multinodular 1, with or without sertoli-leydig cell tumors 30.5 TPO TG
42 thyroid hormone resistance, generalized, autosomal dominant 30.5 TSHR TRH TG SERPINA7
43 nontoxic goiter 30.5 TSHR TPO TG SERPINA7 ICOSLG CALCA
44 papillary carcinoma 30.5 TSHR TPO TG RET PAX8 CALCA
45 type 2 diabetes mellitus 30.5 TPO POMC MIR9-1 MIR221 MIR199A1 MIR146B
46 hypoadrenocorticism, familial 30.5 TPO TG POMC
47 thyroiditis 30.5 TSHR TPO TG SERPINA7 RET INS
48 bone disease 30.5 MIR9-1 MIR222 MIR221 MIR199A1 ICOSLG H2AC18
49 eye disease 30.4 TSHR POMC MIR9-1 MIR221 MIR199A1 MIR146B
50 head and neck cancer 30.4 MIR9-1 MIR222 MIR221 MIR199A1 MIR146B ICOSLG

Comorbidity relations with Thyroid Gland Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential Hypothyroidism

Graphical network of the top 20 diseases related to Thyroid Gland Disease:



Diseases related to Thyroid Gland Disease

Symptoms & Phenotypes for Thyroid Gland Disease

MGI Mouse Phenotypes related to Thyroid Gland Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.28 INS MIR138-1 MIR199A1 MIR208A MIR9-1 PAX8

Drugs & Therapeutics for Thyroid Gland Disease

Drugs for Thyroid Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 356)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
2
Nitric Oxide Approved Phase 4 10102-43-9 145068
3
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
6
Prednisolone Approved, Vet_approved Phase 4 50-24-8 4894 5755
7
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
8
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5 1875
9
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 4159 6741
10
Codeine Approved, Illicit Phase 4 76-57-3, 6854-40-6 5284371 5362471
11
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
12
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
13
Tramadol Approved, Investigational Phase 4 27203-92-5 33741 5523
14
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
15
Magnesium sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9
16
Metformin Approved Phase 4 1115-70-4, 657-24-9 4091
17
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
18
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
19
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
20
D-Tyrosine Approved, Experimental, Investigational, Nutraceutical Phase 4 133585-56-5, 60-18-4, 556-02-5 1153 6057
21
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7 4897
22 Vasodilator Agents Phase 4
23 Antineoplastic Agents, Hormonal Phase 4
24 Antiemetics Phase 4
25 Gastrointestinal Agents Phase 4
26
Methylprednisolone Acetate Phase 4 584547
27 Antitussive Agents Phase 4
28 Methylene diphosphonate Phase 4
29 Diphosphonates Phase 4
30 Carboxymethylcellulose Sodium Phase 4
31 Neuroprotective Agents Phase 4
32 Technetium Tc 99m Medronate Phase 4
33 Sodium Channel Blockers Phase 4
34 Diuretics, Potassium Sparing Phase 4
35 Analgesics, Opioid Phase 4
36 Narcotics Phase 4
37 Calcium, Dietary Phase 4
38 Anticonvulsants Phase 4
39 calcium channel blockers Phase 4
40 Tocolytic Agents Phase 4
41 Hormones Phase 4
42 Hormone Antagonists Phase 4
43 glucocorticoids Phase 4
44 Anti-Asthmatic Agents Phase 4
45 Respiratory System Agents Phase 4
46 HIV Protease Inhibitors Phase 4
47
protease inhibitors Phase 4
48 Hypoglycemic Agents Phase 4
49 Insulin, Globin Zinc Phase 4
50
Insulin Phase 4

Interventional clinical trials:

(show top 50) (show all 842)
# Name Status NCT ID Phase Drugs
1 The Beneficial Effect of L-Thyroxine Long -Term Replacement on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism: A Prospective Study Unknown status NCT01831869 Phase 4 L-thyroxine
2 Does Sodium Nitroprusside Infusion Affect Thyroidal Function in Patients Undergoing Coronary Artery Bypass Grafting, a Prospective Randomized Clinical Trial. Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
3 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
4 The Use of Lu177 in the Treatment of Progressive and Unresectable Metastatic Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
5 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
6 Efficacy of Dexmedetomidine for Cough Suppression During Anesthetic Emergence in Patients Undergoing Thyroid Surgery: A Randomized, Double Blinded, Controlled Trial Unknown status NCT03312413 Phase 4 Dexmedetomidine Hydrochloride;Normal Saline
7 Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
8 Randomized Controlled Trial of Preoperative Steroids in Autoimmune Thyroid Disease Completed NCT04542278 Phase 4 Prednisone
9 Minimizing Narcotic Analgesics After Thyroid or Parathyroid Surgery Completed NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
10 Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results Completed NCT00858104 Phase 4
11 Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study Completed NCT00400465 Phase 4
12 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment Completed NCT02491008 Phase 4 Levothyroxine;Placebo
13 A Dosimetry Study of Radioiodine (131-I) Uptake Following the Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal Completed NCT00001730 Phase 4 Thyrogen
14 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
15 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
16 Is it Possible to Increase Quality of Life, Using Recombinant TSH Instead of Withdrawal of Thyroid Hormone Treatment, Before Iodine Uptake in Patients With Thyroid Cancer? Completed NCT00604318 Phase 4 rhTSH
17 Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment Completed NCT03969108 Phase 4 Indocyanine Green
18 A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy. Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
19 Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism. Completed NCT02832934 Phase 4 Levothyroxine;Placebo
20 Impact of Thyroid Hormone Replacement on Cardiac Function: a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism Completed NCT02832960 Phase 4 Levothyroxine;Placebo
21 Intravenous Or Topical Lidocaine And Neuromonitoring in Thyroid Surgery (IOLANT Study) Recruiting NCT04574947 Phase 4 Intravenous lidocaine;Intravenous placebo
22 Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused Recruiting NCT05247476 Phase 4 L-T4;L-T4+T3 (thyroid tablet)
23 Effect of Tramadol on Postoperative Sore Throat in Thyroid Surgery Under General Anesthesia With Endotracheal Intubation: A Randomized Controlled Trial Recruiting NCT04991493 Phase 4 Tramadol hydrochloride
24 Effects of Long-term L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Patients With Hypothyroidism Active, not recruiting NCT01848171 Phase 4 L-thyroxine
25 A Phase 4, Randomized, Double-masked, Placebo-controlled, Multicenter Trial to Evaluate the Efficacy and Safety of TEPEZZA® in Treating Patients With Chronic (Inactive) Thyroid Eye Disease Active, not recruiting NCT04583735 Phase 4 Placebo
26 A Randomized, Double-blind Study To Evaluate the Efficacy and Safety of Cabozantinib (XL184) at 60 mg/Day Compared to a 140 mg/Day in Progressive, Metastatic Medullary Thyroid Cancer Patients Active, not recruiting NCT01896479 Phase 4 Cabozantinib (XL184) 140 mg;Cabozantinib (XL184) 60 mg;Placebo tablet;Placebo capsule
27 Prospective Single Arm Post Marketing Phase IV Study to Assess the Safety and Efficacy of Lenvatinib in Subjects With Locally Recurrent or Metastatic, Progressive, Radioiodine Refractory Differentiated Thyroid Cancer Active, not recruiting NCT03573960 Phase 4 Lenvatinib
28 An International, Randomised, Double-Blind, Two-Arm Study To Evaluate The Safety And Efficacy Of Vandetanib 150 And 300mg/Day In Patients With Unresectable Locally Advanced Or Metastatic Medullary Thyroid Carcinoma With Progressive Or Symptomatic Disease Active, not recruiting NCT01496313 Phase 4 300mg vandetanib;150mg vandetanib
29 Evaluation of Ropivacaine and Ropivacaine Plus Magnesium Sulphate Infiltration for Postoperative Analgesia in Patients Undergoing Thyroidectomy Enrolling by invitation NCT05294393 Phase 4 Placebo Comparator: N/S 0.9%;Ropivacaine 10%;Ropivacaine 10% plus magnesium sulphate 10mg/kg
30 Efficacy of Metformin Versus Sitagliptin on Benign Thyroid Nodules Size in Type 2 Diabetes: a 2-years Prospective Multicentric Study Not yet recruiting NCT04298684 Phase 4 METFORMIN;Sitagliptin
31 Distribution of Selenium in Patients With Differentiated Thyroid Carcinoma and Effect of Selenium Supplement on Prognosis of Patients With Differentiated Thyroid Carcinoma. Not yet recruiting NCT04683575 Phase 4 Selenium Yeast;Placebo
32 Efficacy Evaluation of Strontium-89 Chloride for Differentiated Thyroid Cancer With Bone Metastases Not yet recruiting NCT05466812 Phase 4 Sr-89
33 Local Betamethasone Versus Triamcinolone Injection in Management of Thyroid-Related Upper Lid Retraction With and Without Proptosis Not yet recruiting NCT04976816 Phase 4
34 Evaluation of 99mTc Sestamibi Scans In Patients Who Have Differentiated Thyroid Cancer, Elevated Serum Thyroglobulin Levels, and Negative Diagnostic Imaging Studies Terminated NCT03065218 Phase 4 99mTc sestamibi
35 Phase IV Study of Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Terminated NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
36 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
37 Medico-Economic Comparison of Four Strategies of Radioiodine Ablation in Thyroid Carcinoma Patients - Estimabl Unknown status NCT00435851 Phase 3 Thyrogen, thyroid hormone withdrawal, iode 131
38 A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Trial to Compare the Efficacy and Safety of Anlotinib Versus Placebo in Patients With 131I-Refractory Differentiated Thyroid Cancer(ALTER01032) Unknown status NCT02586337 Phase 2, Phase 3 Anlotinib;Placebo
39 Phase Ⅱ Non-randomized Multicenter Controlled Trial About Effect of Remnant Ablation Therapy on the Recurrence in Low-risk Differentiated Thyroid Cancer Patients Unknown status NCT02418247 Phase 2, Phase 3 I131;I123
40 Effect of the Radioiodine Dose in Thyroid Ablation- A Randomized Comparison of 1110 MBq to 3700 MBq Unknown status NCT00115895 Phase 3 Radioactive iodine
41 Ultrasound Guided Interstitial Laser Photocoagulation on Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
42 Medico-economic Evaluation Comparing the Use of Ultrasonic Scissors to the Conventional Techniques of Haemostasis in Thyroid Surgery by Cervicotomy Unknown status NCT01551914 Phase 3
43 Preoperative Single-dose Steroid Application for the Treatment of Nausea and Vomiting After Thyroid Surgery Completed NCT01189292 Phase 3 Dexamethasone
44 A Phase 3, Randomized, Double-Masked, Placebo-Controlled, Parallel-Group, Multicenter Study Evaluating Teprotumumab (HZN-001) Treatment in Subjects With Active Thyroid Eye Disease Completed NCT03298867 Phase 3
45 The Role of Sentinel Lymph Node Biopsy (SLNB) In the Management of Differentiated Thyroid Cancer Completed NCT00794053 Phase 3
46 Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma: A Prospective Randomized Controlled Trial Completed NCT00795782 Phase 3
47 Prospective, Randomized, Double Blind, Multicenter Study for Hyalobarrier ® to Evaluate Anti-adhesive Effect and Safety Compared to Guardix-SG® After Thyroidectomy Completed NCT01696305 Phase 3
48 Thyroid Hormones Homeostasis and Energy Metabolism Changes During Stimulation of Endogenously Secreted Bile Acids (BAs) Completed NCT00706381 Phase 3 Sincalide;Ursodiol;Placebo
49 A Pivotal Phase III Study of Cyclotron-produced Tc-99m Pertechnetate (CTC) Compared to Generator-produced Tc-99m Pertechnetate (G-PERT) in Subjects With Thyroid Disorders Completed NCT02980679 Phase 3 CTC;G-PERT
50 An International, Randomized, Double-Blinded, Phase 3 Efficacy Study of XL184 Versus Placebo in Subjects With Unresectable, Locally Advanced, or Metastatic Medullary Thyroid Cancer Completed NCT00704730 Phase 3 XL184;Placebo

Search NIH Clinical Center for Thyroid Gland Disease

Cochrane evidence based reviews: thyroid diseases

Genetic Tests for Thyroid Gland Disease

Genetic tests related to Thyroid Gland Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Thyroid Gland 28

Anatomical Context for Thyroid Gland Disease

Organs/tissues related to Thyroid Gland Disease:

FMA: Thyroid
MalaCards : Thyroid, Lymph Node, Eye, Salivary Gland, Brain, Breast, Fetal Thyroid

Publications for Thyroid Gland Disease

Articles related to Thyroid Gland Disease:

(show top 50) (show all 75)
# Title Authors PMID Year
1
Transaxillary gasless endoscopic hemithyroidectomy versus conventional open hemithyroidectomy: early single-centre experience. 62
35489003 2022
2
Thyroid Gland Disease as a Comorbid Condition in COPD. 62
34745661 2021
3
Quantitative Assessment of Thyroid Glands in Healthy Children With Shear Wave Elastography. 62
30724864 2019
4
Oral lichen planus and thyroid gland diseases: possible associations. 62
31366342 2019
5
Annual Incidence of Thyroid Disease in Patients Who First Time Visit Department for Thyroid Diseases in Tuzla Canton. 62
31452639 2019
6
Retrosternal Goiter: A couple of classification methods with computed tomograpy findings. 62
30559810 2018
7
Multi-immunoreaction-based dual-color capillary electrophoresis for enhanced diagnostic reliability of thyroid gland disease. 62
28645753 2017
8
Surgical treatment of concomitant thyroid and parathyroid disorders: analysis of 4882 cases. 62
27619822 2017
9
From Neck Swelling to Abrupt Compromised Airway: A Case of a Hemorrhagic Ruptured Thyroid Cyst. 62
30787737 2016
10
Antibodies reacting to carbonic anhydrase isozymes (I and II) and albumin in sera from dogs. 62
27234558 2016
11
Thyroid Hemiagenesis from Childhood to Adulthood: Review of Literature and Personal Experience. 62
27116848 2016
12
Transcriptional activity of TGFβ1 and its receptors genes in thyroid gland. 62
27345036 2016
13
Comparison of the results of total thyroidectomy and Dunhill operation in surgical treatment of multinodular goiter. 62
27011525 2015
14
Sonographic Reference Ranges for the Thyroid Gland in Euthyroid Term Newborns. 62
26023906 2015
15
Importance of ectopic thyroid tissue detected in the midline of the neck: single center experience. 62
26331224 2015
16
Does Papillary Carcinoma of Thyroglossal Duct Cyst Develop De Novo? 62
26351606 2015
17
Do thyroid ultrasonographic features change according to age in euthyroid dogs? 62
24450935 2014
18
Cost-of-Illness Trend of Thyroid Gland Disease in Korea. 62
25309782 2014
19
Multiple symmetric lipomatosis: a diagnostic dilemma. 62
23983713 2013
20
Modern concepts of preoperative preparation of patients with thyroid gland disease. 62
21879658 2011
21
Rare developmental abnormalities of thyroid gland, especially multiple ectopia: A review and our experience. 62
21713222 2010
22
Localized crossed hyperhidrosis and the coexistence of thyroid gland disease. 62
20536672 2010
23
Malignant struma ovarii: a case report. 62
20119594 2010
24
A report of ten patients with thyroid hemiagenesis: ultrasound screening in patients with thyroid disease. 62
20033860 2010
25
[Methodology for evaluation of malignancy screening in surgical thyroid gland disease]. 62
19850274 2009
26
[Activity of antioxidative enzymes and concentration of malondialdehyde as oxidative status markers in women with non-autoimmunological subclinical hyperthyroidism]. 62
19569020 2009
27
Euthyroid pretibial myxedema and EMO syndrome. 62
19350184 2009
28
Application of thermography for non-invasive diagnosis of thyroid gland disease. 62
18334410 2008
29
Computed tomographic features of the normal canine thyroid gland. 62
18251288 2008
30
[Hyperparathyroidism, goiter and well-differentiated thyroid carcinoma. A common association with diagnostic implications]. 62
17580029 2007
31
Methodology of the thyroid gland disease decision-making using profiling in steroid hormone pathway. 62
17081718 2007
32
[Classification of thyroid gland disease on the basis of selenium concentration in serum]. 62
18246662 2007
33
Papillary thyroid carcinoma in thyroglossal duct cyst: case reports and literature review. 62
16845854 2006
34
[Clinical features of hypothyroidism depending on intensity of excitatory processes in the central nervous system]. 62
17100184 2006
35
[Surgical treatment of thyreopathies. Retrospective assessment of the authors' study group]. 62
16541632 2006
36
Glucose transporter-1 expression in the thyroid gland: clinicopathological significance for papillary carcinoma. 62
16273245 2005
37
[Subclinical and manifested hypothyroidism as a consequence of thyroid autoimmune disease]. 62
16405254 2005
38
[Diagnosis of osteoporosis occurring in autoimmune thyroid gland disease]. 62
16405255 2005
39
Relationship between the regulatory region polymorphism of human tissue kallikrein gene and essential hypertension. 62
15905889 2005
40
[Management of thyroid disease-induced tracheostenosis]. 62
16109576 2005
41
[Surgical treatment of thyroid gland diseases]. 62
16018392 2005
42
[Selenium concentration in serum of women with thyroid gland disease]. 62
16080447 2005
43
Development of a validated HPLC method for the determination of iodotyrosines and iodothyronines in pharmaceuticals and biological samples using solid phase extraction. 62
15607721 2005
44
Thyroid gland diseases in Kano. 62
15300270 2004
45
[Autoimmune processes in diseases of the thyroid gland]. 62
14692138 2003
46
[The complications of reoperation for thyroid disease after a thyroidectomy]. 62
12815891 2003
47
[Pathomorphology of the thyroid gland after treatment of laryngeal cancer]. 62
12741141 2003
48
[Thyroid gland nodules registered at the Endocrinology Department of the Medical Center in Prokuplje]. 62
10953554 2000
49
[Increased level of TSH can be a sign of adrenal cortex failure. Not necessarily thyroid gland disease]. 62
10064931 1999
50
Thyroglossal duct carcinoma: presentation and management, including eight cases reports. 62
9704182 1998

Variations for Thyroid Gland Disease

ClinVar genetic disease variations for Thyroid Gland Disease:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 COL7A1 NM_000094.4(COL7A1):c.1442G>A (p.Arg481His) SNV Likely Pathogenic
373954 rs147040026 GRCh37: 3:48629171-48629171
GRCh38: 3:48591738-48591738

Expression for Thyroid Gland Disease

Search GEO for disease gene expression data for Thyroid Gland Disease.

Pathways for Thyroid Gland Disease

Pathways related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.35 TSHR TRH POMC
2
Show member pathways
11.25 MIR9-1 MIR222 MIR221 MIR199A1 MIR146B
3 11.12 MIR9-1 MIR199A1 MIR146B
4 10.23 TSHR TRH TPO TG

GO Terms for Thyroid Gland Disease

Cellular components related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.89 TPO TG SERPINA7 POMC MIR222 MIR221
2 RISC complex GO:0016442 9.4 MIR9-1 MIR222 MIR221 MIR199A1 MIR146B MIR138-1

Biological processes related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 miRNA-mediated gene silencing GO:0035195 10.21 MIR138-1 MIR146B MIR199A1 MIR208A MIR221 MIR222
2 cell-cell signaling GO:0007267 10.13 TSHR TRH POMC INS CALCA
3 negative regulation of inflammatory response GO:0050728 9.81 MIR222 MIR221 MIR199A1 MIR138-1
4 negative regulation of osteoblast differentiation GO:0045668 9.74 MIR9-1 MIR208A MIR138-1
5 positive regulation of G1/S transition of mitotic cell cycle GO:1900087 9.72 MIR222 MIR221 MIR208A
6 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 9.71 MIR222 MIR221 MIR208A
7 positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 9.56 MIR208A MIR199A1
8 thyroid-stimulating hormone signaling pathway GO:0038194 9.56 TSHR PAX8
9 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.52 MIR208A MIR199A1
10 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.49 MIR222 MIR221
11 negative regulation of hematopoietic stem cell proliferation GO:1902034 9.46 MIR222 MIR221
12 negative regulation of interleukin-21 production GO:0032705 9.4 MIR222 MIR221
13 negative regulation of TRAIL-activated apoptotic signaling pathway GO:1903122 9.37 MIR222 MIR221
14 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.35 MIR9-1 MIR222 MIR221 MIR208A MIR138-1
15 positive regulation of Schwann cell migration GO:1900149 9.32 MIR222 MIR221
16 positive regulation of protein kinase B signaling GO:0051897 9.23 RET MIR222 MIR221 MIR199A1 MIR138-1 INS
17 positive regulation of Schwann cell proliferation involved in axon regeneration GO:1905046 9.16 MIR222 MIR221

Molecular functions related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.61 TRH TG POMC INS CALCA
2 thyroid-stimulating hormone receptor activity GO:0004996 9.46 TSHR PAX8
3 mRNA base-pairing translational repressor activity GO:1903231 9.17 MIR9-1 MIR222 MIR221 MIR208A MIR199A1 MIR146B

Sources for Thyroid Gland Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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