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MCID: THY030
MIFTS: 51

Thyroid Gland Disease

Categories: Endocrine diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Thyroid Gland Disease

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MalaCards integrated aliases for Thyroid Gland Disease:

Name: Thyroid Gland Disease 12 15
Abnormality of the Thyroid Gland 29 6
Thyroid Diseases 44 73

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:50
ICD10 33 E00-E07 E07.9
MeSH 44 D013959
NCIt 50 C26893
UMLS 73 C0040128
Sources

Summaries for Thyroid Gland Disease

About this section
Disease Ontology : 12 An endocrine system disease that is located in the thyroid.

MalaCards based summary : Thyroid Gland Disease, also known as abnormality of the thyroid gland, is related to graves disease 1 and hyperthyroidism. An important gene associated with Thyroid Gland Disease is TG (Thyroglobulin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Allograft rejection. The drugs Hyaluronic acid and Menthol have been mentioned in the context of this disorder. Affiliated tissues include the thyroid, thyroid and eye, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Sources

Related Diseases for Thyroid Gland Disease

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Diseases related to Thyroid Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 graves disease 1 31.1 DIO2 SERPINA7 TG THRB TPO TRH
2 hyperthyroidism 30.9 INS PRL SERPINA7 TG THRB TPO
3 goiter 29.7 CALCA DUOXA2 PAX8 SERPINA7 SLC26A4 TG
4 thyroiditis 29.5 CALCA SERPINA7 TG THRB TPO TRH
5 hypothyroidism 27.0 CALCA DIO2 DIO3 DUOXA2 FOXE1 PAX8
6 autoimmune thyroid disease 3 12.2
7 igg4-related thyroid disease 11.9
8 autoimmune thyroid disease 1 11.9
9 autoimmune thyroid disease 2 11.9
10 autoimmune thyroid disease 4 11.9
11 subacute lymphocytic thyroiditis 11.0 TG TPO
12 benign struma ovarii 11.0 TG TSHR
13 goiter, multinodular 1, with or without sertoli-leydig cell tumors 11.0 TG TPO
14 hypothyroidism, congenital, nongoitrous, 3 10.9 THRA THRB
15 myxedema 10.9 TG TPO TSHR
16 endocrine exophthalmos 10.9 POMC TG
17 plummer's disease 10.9 TG THRB TPO
18 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.9 FOXE1 TG TPO
19 mucoepidermoid thyroid carcinoma 10.9 CALCA TG
20 tsh producing pituitary tumor 10.9 PRL TSHB
21 water-clear cell adenoma 10.8 PAX8 TG
22 familial thyroid dyshormonogenesis 10.8 DUOXA2 TG TPO
23 hypersensitivity reaction disease 10.8 TG TPO TSHR
24 exophthalmos 10.8 PRL TG TSHR
25 suppurative thyroiditis 10.8 CALCA TG
26 kashin-beck disease 10.8 DIO2 TXNRD2
27 anaplastic thyroid cancer 10.8 PAX8 TG TPO
28 thyroid sarcoma 10.8 CALCA TG
29 pituitary infarct 10.8 POMC PRL
30 subacute thyroiditis 10.8 SERPINA7 TG TPO TSHR
31 pseudohypoparathyroidism, type ia 10.8 PRL TRH
32 autoimmune disease of endocrine system 10.8 SERPINA7 TG TPO TSHR
33 thyroid crisis 10.7 POMC TG
34 papillary thyroid microcarcinoma 10.7 CALCA TG TSHR
35 hyperthyroxinemia 10.7 SERPINA7 TPO TRH TSHR
36 struma ovarii 10.7 TG TSHR
37 suprasellar meningioma 10.7 POMC TRH TSHB
38 euthyroid sick syndrome 10.7 DIO2 POMC SERPINA7
39 neonatal hypothyroidism 10.7 PAX8 TG TPO TSHR
40 adenohypophysitis 10.7 POMC PRL TRH
41 scleredema adultorum 10.7 INS POMC
42 empty sella syndrome 10.7 POMC PRL TRH
43 functioning pituitary adenoma 10.6 POMC PRL TRH
44 ovarian cystic teratoma 10.6 CALCA PRL TG
45 atypical follicular adenoma 10.6 CALCA TG
46 organ system benign neoplasm 10.6 POMC PRL TRH
47 hypothalamic disease 10.6 POMC PRL
48 pituitary hormone deficiency, combined, 2 10.6 POMC PRL TSHB
49 dyshormonogenic goiter 10.6 DUOXA2 SERPINA7 SLC26A4 TG
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.6 INS TG TPO TSHR

Comorbidity relations with Thyroid Gland Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential Hypothyroidism

Graphical network of the top 20 diseases related to Thyroid Gland Disease:



Diseases related to Thyroid Gland Disease
Sources

Symptoms & Phenotypes for Thyroid Gland Disease

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MGI Mouse Phenotypes related to Thyroid Gland Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.25 FOXE1 TG INS THRA PAX8 THRB
2 growth/size/body region MP:0005378 10.22 FOXE1 TG INS THRA PAX8 THRB
3 homeostasis/metabolism MP:0005376 10.2 FOXE1 TG INS THRA PAX8 THRB
4 nervous system MP:0003631 9.9 SLC26A4 TG INS THRA PAX8 THRB
5 hearing/vestibular/ear MP:0005377 9.85 SLC26A4 THRA PAX8 TPO TSHR THRB
6 limbs/digits/tail MP:0005371 9.73 DUOXA2 THRA PAX8 TPO TSHR THRB
7 reproductive system MP:0005389 9.61 SLC26A4 INS THRA PAX8 PRL DIO3
8 skeleton MP:0005390 9.28 DUOXA2 SLC26A4 INS THRA PAX8 DIO2
Sources

Drugs & Therapeutics for Thyroid Gland Disease

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Drugs for Thyroid Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 799)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 9004-61-9 53477741
2
Menthol Approved Phase 4,Phase 3,Phase 2,Not Applicable 2216-51-5 16666
3
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 7782-49-2
4
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-52-5 657298
5
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
6
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
7
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
8
Ribavirin Approved Phase 4,Phase 2,Phase 3 36791-04-5 37542
9
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
10
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
11
Iron Approved Phase 4,Phase 2,Phase 1,Not Applicable 7439-89-6 23925
12
Hydroxocobalamin Approved Phase 4,Phase 2,Not Applicable 13422-51-0 11953898 44475014
13
Acetylcholine Approved Phase 4,Phase 2,Phase 3 51-84-3 187
14
Amiodarone Approved, Investigational Phase 4,Phase 3 1951-25-3 2157
15
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
16
Sunitinib Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 341031-54-7, 557795-19-4 5329102
17
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 7553-56-2 807
18
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068 160954
19
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
20
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
21
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
22
Liraglutide Approved Phase 4,Phase 3,Phase 2,Not Applicable 204656-20-2 44147092
23
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
24
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 525-66-6 4946
25
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
26
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
27
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
28
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702
29
Testosterone Approved, Investigational Phase 4,Phase 1,Early Phase 1,Not Applicable 58-22-0 6013
30
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
31
Dinoprost Tromethamine Approved, Vet_approved Phase 4,Not Applicable 38562-01-5 5282415
32
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
33
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 2,Phase 3 198153-51-4 5360545
34
Peginterferon alfa-2b Approved Phase 4,Phase 2,Phase 3 99210-65-8, 215647-85-1
35
Salmon Calcitonin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 47931-85-1 16129616
36
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865
37
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 38916-34-6, 51110-01-1 53481605
38
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6 23994
39
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
40
rituximab Approved Phase 4,Phase 2,Phase 3,Phase 1 174722-31-7 10201696
41
alemtuzumab Approved, Investigational Phase 4,Phase 2 216503-57-0
42
Sertraline Approved Phase 4,Phase 3,Not Applicable 79617-96-2 68617
43
Copper Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 7440-50-8 27099
44
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 1 439-14-5 3016
45
Celecoxib Approved, Investigational Phase 4,Phase 2 169590-42-5 2662
46
Bupivacaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2180-92-9, 38396-39-3 2474
47
Clonidine Approved Phase 4,Phase 2 4205-90-7 2803
48
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
49
Exemestane Approved, Investigational Phase 4 107868-30-4 60198
50
Ephedrine Approved Phase 4,Phase 3,Phase 2 299-42-3 9294

Interventional clinical trials:

(show top 50) (show all 1788)
# Name Status NCT ID Phase Drugs
1 rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
2 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
3 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
4 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
5 Etoricoxib for Postoperative Pain After Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
6 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
7 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4 Methimazole
8 Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery Unknown status NCT01189721 Phase 4 propofol, sevoflurane
9 Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
10 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
11 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
12 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
13 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
14 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
15 Trial Evaluating Use of Arista in Total Thyroidectomy Unknown status NCT02568085 Phase 4
16 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
17 Effect of Nasal CPAP on Lipid Profile in Patients With Dyslipidaemia and Sleep Apnea Unknown status NCT02557412 Phase 4
18 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
19 Thyroxine Titration Study Unknown status NCT00111735 Phase 4 Thyroxine
20 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
21 Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial Unknown status NCT02211053 Phase 4 Levothyroxine;placebo
22 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
23 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
24 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
25 Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Completed NCT00858104 Phase 4
26 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4 Levothyroxine;Placebo
27 Quality of Life, Recombinant TSH (Thyrogen) and Thyroid Cancer Completed NCT00604318 Phase 4 rhTSH
28 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4 Thyrogen
29 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4 Levothyroxine;Placebo
30 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
31 A Comparison of Patch vs. Pill Estrogen Therapy on Testosterone Levels and Thyroid Tests in Menopausal Women Completed NCT00224094 Phase 4 Premarin® (oral) vs. Alora® (transdermal)
32 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
33 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4 Levothyroxine;Placebo
34 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
35 Thyroid Medication and Antidepressants for Treating Major Depression Completed NCT00208702 Phase 4 Triiodothyronine;Sertraline
36 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
37 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
38 Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial Completed NCT00520338 Phase 4 celecoxib
39 The Effect of Metformin Treatment on Thyroid Hormone Metabolism in Euthyroid Patients With Type 2 Diabetes Mellitus Completed NCT00463502 Phase 4 Metformin
40 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
41 The TRUST Study - Depression Substudy Completed NCT01853579 Phase 4 Levothyroxine;Placebo
42 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
43 Effects of N-acetylcysteine on Low T3 Syndrome Completed NCT01501110 Phase 4 N-acetylcysteine
44 Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia Completed NCT01308320 Phase 4 fentanyl citrate;saline
45 Effects of L-carnitine on Hypothyroidism Completed NCT01769157 Phase 4 L-carnitine;Placebo
46 Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty
47 Study of Optimal Replacement of Thyroxine in the Elderly Completed NCT01647750 Phase 4 Levothyroxine;Levothyroxine
48 Tizanidine and Superficial Cervical Block on Pain After Thyroidectomy Completed NCT02725359 Phase 4 Placebo;Tizanidine;Bupivacaine;Saline
49 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Recombinant human growth hormone
50 Effects of Tribulus Terrestris in Postmenopausal Women With Hypoactive Sexual Desire Disorder Completed NCT01975649 Phase 4 Tribulus Terrestris

Search NIH Clinical Center for Thyroid Gland Disease

Cochrane evidence based reviews: thyroid diseases

Sources

Genetic Tests for Thyroid Gland Disease

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Genetic tests related to Thyroid Gland Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Thyroid Gland 29
Sources

Anatomical Context for Thyroid Gland Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Thyroid Gland Disease:

19
The Thyroid

MalaCards organs/tissues related to Thyroid Gland Disease:

41
Thyroid, Eye, Heart, Testes, Lung, Brain, Lymph Node
Sources

Publications for Thyroid Gland Disease

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Articles related to Thyroid Gland Disease:

# Title Authors Year
1
Multi-immunoreaction-based dual-color capillary electrophoresis for enhanced diagnostic reliability of thyroid gland disease. ( 28645753 )
2017
2
Cost-of-Illness Trend of Thyroid Gland Disease in Korea. ( 25309782 )
2014
3
Modern concepts of preoperative preparation of patients with thyroid gland disease. ( 21879658 )
2011
4
Localized crossed hyperhidrosis and the coexistence of thyroid gland disease. ( 20536672 )
2010
5
Application of thermography for non-invasive diagnosis of thyroid gland disease. ( 18334410 )
2008
6
Methodology of the thyroid gland disease decision-making using profiling in steroid hormone pathway. ( 17081718 )
2007
7
[Classification of thyroid gland disease on the basis of selenium concentration in serum]. ( 18246662 )
2007
8
[Diagnostics, treatment, and prevention of iatrogenic iodine-induced thyroid gland diseases]. ( 16544899 )
2006
9
Immunohistochemical study of ceruloplasmin, lactoferrin and secretory component expression in neoplastic and non-neoplastic thyroid gland diseases. ( 11130016 )
2000
10
Indications for surgery in thyroid gland disease. ( 13612484 )
1958
Sources

Variations for Thyroid Gland Disease

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ClinVar genetic disease variations for Thyroid Gland Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 COL7A1 NM_000094.3(COL7A1): c.1442G> A (p.Arg481His) single nucleotide variant Likely pathogenic rs147040026 GRCh38 Chromosome 3, 48591738: 48591738
2 COL7A1 NM_000094.3(COL7A1): c.1442G> A (p.Arg481His) single nucleotide variant Likely pathogenic rs147040026 GRCh37 Chromosome 3, 48629171: 48629171
Sources

Expression for Thyroid Gland Disease

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Search GEO for disease gene expression data for Thyroid Gland Disease.
Sources

Pathways for Thyroid Gland Disease

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Pathways related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 66
Show member pathways
 13.38 CALCA POMC PRL THRA THRB TRH
2
Allograft rejection 1 37
Show member pathways
 12.69 INS TG TPO TSHB TSHR
3
Aldosterone synthesis and secretion 37
Show member pathways
 12.52 DUOXA2 INS PAX8 POMC SERPINA7 SLC26A4
4
Angiopoietin Like Protein 8 Regulatory Pathway 1
Show member pathways
 12.32 DIO2 INS THRA THRB
5
Folate Metabolism 1
Show member pathways
 12.13 DIO2 DIO3 INS TXNRD2
6
G alpha (s) signalling events 66
11.83 CALCA POMC TSHB TSHR
7
Thyroid hormone signaling pathway 37
11.62 DIO2 DIO3 THRA THRB
8
Human Thyroid Stimulating Hormone (TSH) signaling pathway 1
11.49 PAX8 TSHB TSHR
9
Regulation of lipolysis in adipocytes 37
11.37 INS TSHB TSHR
10
Selenium Metabolism and Selenoproteins 1
11.27 DIO2 DIO3 TXNRD2
11
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.23 CALCA THRA THRB
12
Amine-derived hormones 66
Show member pathways
 11.06 DIO2 DIO3 TPO TSHB
13
Hormone ligand-binding receptors 66
10.64 TSHB TSHR
14
thyronamine and iodothyronamine metabolism 1
Show member pathways
 9.92 DIO2 DIO3
15
Thyroxine (Thyroid Hormone) Production 1
9.7 TG TPO TRH TSHR
Sources

GO Terms for Thyroid Gland Disease

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Cellular components related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 CALCA INS POMC PRL SERPINA7 TG
2 endosome lumen GO:0031904 8.96 INS PRL

Biological processes related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.88 CALCA INS POMC TRH TSHB TSHR
2 regulation of signaling receptor activity GO:0010469 9.87 CALCA INS POMC PRL TG TRH
3 regulation of heart contraction GO:0008016 9.69 CALCA THRA THRB
4 peptide hormone processing GO:0016486 9.56 POMC TSHB
5 thyroid hormone generation GO:0006590 9.56 DIO2 DIO3 FOXE1 TPO
6 negative regulation of feeding behavior GO:2000252 9.55 INS TRH
7 Type I pneumocyte differentiation GO:0060509 9.54 THRA THRB
8 thyroid hormone metabolic process GO:0042403 9.54 DIO2 DIO3 TG
9 iodide transport GO:0015705 9.52 SLC26A4 TG
10 thyroid hormone mediated signaling pathway GO:0002154 9.49 THRA THRB
11 thyroid-stimulating hormone signaling pathway GO:0038194 9.48 PAX8 TSHR
12 thyroid hormone catabolic process GO:0042404 9.46 DIO2 DIO3
13 hormone biosynthetic process GO:0042446 9.46 DIO2 DIO3 TG TPO
14 female courtship behavior GO:0008050 9.43 THRA THRB
15 hormone-mediated signaling pathway GO:0009755 9.35 THRA THRB TRH TSHB TSHR
16 thyroid gland development GO:0030878 9.02 FOXE1 PAX8 TG THRA THRB

Molecular functions related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor activity, direct ligand regulated sequence-specific DNA binding GO:0098531 9.37 THRA THRB
2 thyroxine 5-deiodinase activity GO:0004800 9.33 DIO2 DIO3
3 thyroxine 5-deiodinase activity GO:0033798 9.33 DIO3
4 thyroid hormone receptor activity GO:0004887 9.32 THRA THRB
5 thyroid hormone binding GO:0070324 9.26 THRA THRB
6 hormone activity GO:0005179 9.17 CALCA INS POMC PRL TG TRH
7 thyroid-stimulating hormone receptor activity GO:0004996 8.96 PAX8 TSHR
Sources

Sources for Thyroid Gland Disease

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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