MCID: THY030
MIFTS: 43

Thyroid Gland Disease

Categories: Endocrine diseases

Aliases & Classifications for Thyroid Gland Disease

MalaCards integrated aliases for Thyroid Gland Disease:

Name: Thyroid Gland Disease 12 15
Abnormality of the Thyroid Gland 29 6
Thyroid Diseases 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:50
ICD10 33 E00-E07 E07.9
MeSH 44 D013959
NCIt 50 C26893
SNOMED-CT 68 14304000
UMLS 73 C0040128

Summaries for Thyroid Gland Disease

Disease Ontology : 12 An endocrine system disease that is located in the thyroid.

MalaCards based summary : Thyroid Gland Disease, also known as abnormality of the thyroid gland, is related to hyperthyroxinemia and hyperthyroidism. An important gene associated with Thyroid Gland Disease is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and G alpha (s) signalling events. The drugs Iodine and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lung and ovary, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Thyroid Gland Disease

Diseases related to Thyroid Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 250)
# Related Disease Score Top Affiliating Genes
1 hyperthyroxinemia 32.0 SERPINA7 TPO TRH TSHR
2 hyperthyroidism 31.7 SERPINA7 TG THRB TPO TRH TSHR
3 graves disease 1 31.6 SERPINA7 TG THRB TPO TRH TSHR
4 thyroid cancer 31.2 CALCA FOXE1 NCOA4 NKX2-1 PAX8 RET
5 goiter 31.1 CALCA NKX2-1 PAX8 SERPINA7 SLC26A4 SLC5A5
6 hypothyroidism 30.9 CALCA DIO3 FOXE1 NKX2-1 PAX8 RET
7 graves' disease 30.4 SERPINA7 TG THRB TPO TSHR
8 myxedema 30.3 TG TPO TSHR
9 thyroid carcinoma, familial medullary 30.3 CALCA NKX2-1 RET TG
10 thyroiditis 30.2 CALCA RET SERPINA7 TG THRB TPO
11 nodular goiter 30.0 CALCA RET SLC5A5 TG TPO TSHR
12 neonatal hypothyroidism 30.0 PAX8 SLC5A5 TG TPO TSHR
13 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 29.9 TG TPO TSHR
14 subacute thyroiditis 29.9 SERPINA7 TG TPO TSHR
15 hashimoto thyroiditis 29.8 CALCA RET SLC26A4 TG TPO TSHB
16 endemic goiter 29.8 SERPINA7 TG TPO TSHB TSHR
17 papillary carcinoma 29.7 CALCA NCOA4 NKX2-1 PAX8 RET TG
18 multinodular goiter 29.7 CALCA NKX2-1 PAX8 SLC26A4 TG TPO
19 cowden disease 29.7 CALCA RET TG
20 pendred syndrome 29.6 PAX8 SLC26A4 TG TPO
21 hypothyroidism, congenital, nongoitrous, 4 29.5 SERPINA7 TG TPO TRH TSHB
22 differentiated thyroid carcinoma 29.5 FOXE1 NCOA4 NKX2-1 PAX8 RET TG
23 congenital hypothyroidism 29.4 FOXE1 NKX2-1 PAX8 SERPINA7 SLC26A4 SLC5A5
24 follicular adenoma 29.3 CALCA NKX2-1 PAX8 RET SLC26A4 TG
25 autoimmune thyroid disease 3 12.3
26 igg4-related thyroid disease 12.1
27 autoimmune thyroid disease 1 12.1
28 autoimmune thyroid disease 2 12.1
29 autoimmune thyroid disease 4 12.1
30 autoimmune polyendocrine syndrome, type ii 11.6
31 vitiligo-associated multiple autoimmune disease susceptibility 1 11.1
32 granuloma annulare 11.1
33 candidiasis, familial, 1 10.9
34 carpal tunnel syndrome 10.8
35 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 10.8
36 cholangitis, primary sclerosing 10.8
37 mthfr gene variant 10.8
38 mucoepidermoid thyroid carcinoma 10.3 CALCA TG
39 subacute lymphocytic thyroiditis 10.3 TG TPO
40 hashimoto encephalopathy 10.3 TPO TSHR
41 suppurative thyroiditis 10.3 CALCA TG
42 thyroid sarcoma 10.3 CALCA TG
43 acute thyroiditis 10.3 CALCA FOXE1 TG
44 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TG TPO
45 atypical follicular adenoma 10.3 CALCA TG
46 water-clear cell adenoma 10.3 PAX8 TG
47 ovarian germ cell teratoma 10.3 NKX2-1 RET TG
48 familial thyroid dyshormonogenesis 10.3 SLC5A5 TG TPO
49 plummer's disease 10.3 TG THRB TPO
50 postsurgical hypothyroidism 10.3 TG TRH TSHR

Comorbidity relations with Thyroid Gland Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential Hypothyroidism

Graphical network of the top 20 diseases related to Thyroid Gland Disease:



Diseases related to Thyroid Gland Disease

Symptoms & Phenotypes for Thyroid Gland Disease

GenomeRNAi Phenotypes related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.12 RET
2 Decreased viability GR00221-A-2 10.12 RET
3 Decreased viability GR00221-A-4 10.12 RET
4 Decreased viability GR00231-A 10.12 RET
5 Decreased viability GR00240-S-1 10.12 PAX8 SLC5A5 TG
6 Decreased viability GR00301-A 10.12 RET
7 Decreased viability GR00381-A-1 10.12 CALCA
8 Decreased viability GR00402-S-2 10.12 CALCA DIO3 FOXE1 NCOA4 NKX2-1 PAX8
9 no effect GR00402-S-1 9.62 CALCA DIO3 FOXE1 NCOA4 NKX2-1 PAX8

MGI Mouse Phenotypes related to Thyroid Gland Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.13 DIO3 FOXE1 NCOA4 NKX2-1 PAX8 RET
2 endocrine/exocrine gland MP:0005379 10.11 FOXE1 NKX2-1 PAX8 RET SLC26A4 SLC5A5
3 cellular MP:0005384 10.1 DIO3 NCOA4 NKX2-1 PAX8 RET SLC5A5
4 growth/size/body region MP:0005378 10.06 DIO3 FOXE1 NKX2-1 PAX8 RET TG
5 limbs/digits/tail MP:0005371 9.63 PAX8 RET TG THRB TPO TSHR
6 no phenotypic analysis MP:0003012 9.5 NKX2-1 PAX8 RET THRB TPCN1 TRH
7 reproductive system MP:0005389 9.23 DIO3 NKX2-1 PAX8 RET SLC26A4 THRB

Drugs & Therapeutics for Thyroid Gland Disease

Drugs for Thyroid Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 847)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 7553-56-2 807
2
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 3,Not Applicable 9004-61-9 53477741
3
Dexmedetomidine Approved, Vet_approved Phase 4,Not Applicable 113775-47-6 68602 5311068
4
Diclofenac Approved, Vet_approved Phase 4,Phase 3 15307-86-5 3033
5
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
6
Selenium Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 7782-49-2
7
Methimazole Approved Phase 4,Phase 2,Phase 1,Not Applicable 60-56-0 1349907
8
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
9
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
10
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
11
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068
12
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
13
Propylthiouracil Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 51-52-5 657298
14
Betamethasone Approved, Vet_approved Phase 4,Phase 3 378-44-9 9782
15
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
16
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 53-03-2 5865
17
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
18 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19
Amiodarone Approved, Investigational Phase 4,Phase 3,Not Applicable 1951-25-3 2157
20
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 94-09-7, 1994-09-7 2337
21
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51110-01-1, 38916-34-6 53481605
22
Pasireotide Approved Phase 4,Phase 3,Phase 2 396091-73-9 9941444
23
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 83150-76-9 383414 6400441
24 lanreotide Approved Phase 4,Phase 2 108736-35-2
25
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 302-25-0
26
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-24-8 5755
27
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2921-57-5
28
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 83-43-2 6741
29
Triamcinolone Approved, Vet_approved Phase 4,Not Applicable 124-94-7 31307
30 Estradiol valerate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 979-32-8
31
Testosterone Approved, Investigational Phase 4,Phase 1,Early Phase 1,Not Applicable 58-22-0 6013
32
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 50-28-2 5757
33
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 28014-46-2
34
Dinoprost Tromethamine Approved, Vet_approved Phase 4,Not Applicable 38562-01-5 5282415
35
Dinoprost Approved, Investigational Phase 4,Not Applicable 551-11-1 5283078
36
Metformin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 657-24-9 14219 4091
37
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 525-66-6 4946
38
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 2,Phase 3 198153-51-4 5360545
39
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-02-2 5743
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1177-87-3
41
Hydroxocobalamin Approved Phase 4,Phase 2,Not Applicable 13422-51-0 11953898 44475014
42
Iron Approved Phase 4,Phase 2,Phase 1,Not Applicable 7439-89-6 23925
43
leucovorin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
44
Ribavirin Approved Phase 4,Phase 2,Phase 3 36791-04-5 37542
45
Peginterferon alfa-2b Approved Phase 4,Phase 2,Phase 3 99210-65-8, 215647-85-1
46
Sunitinib Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 557795-19-4, 341031-54-7 5329102
47
Liraglutide Approved Phase 4,Phase 3,Phase 2,Not Applicable 204656-20-2 44147092
48
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Not Applicable 103-90-2 1983
49
Salmon Calcitonin Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 47931-85-1 16129616
50
Ethanol Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 64-17-5 702

Interventional clinical trials:

(show top 50) (show all 1919)
# Name Status NCT ID Phase Drugs
1 rAd-p53 Gene Therapy for Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
2 Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
3 Radiolabeled Molecules for Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
4 Thyroid Study Type 2 Diabetes Mellitus (T2DM) Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
5 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
6 Etoricoxib for Postoperative Pain After Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
7 Selenium Supplementation in Youths With Autoimmune Thyroiditis Unknown status NCT02644707 Phase 4
8 Cardiopulmonary Capacity in Elderly With Different Ranges of Serum Thyroid Stimulating Hormone Unknown status NCT01849861 Phase 4 Methimazole
9 Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery Unknown status NCT01189721 Phase 4 propofol, sevoflurane
10 Clinical Study Investigating the Effect of Sodium Nitroprusside Infusion on Thyroidal Function Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
11 The Effect of Early Total Thyroidectomy in the Course of Graves' Orbitopathy Unknown status NCT01056419 Phase 4 Propylthiouracil
12 Total Thyroidectomy With Harmonic Scalpel® Unknown status NCT00385983 Phase 4
13 The Role of Levothyroxine on Goiter With Atypia of Undetermined Significance Unknown status NCT02329379 Phase 4 Levothyroxine
14 Effects of Levothyroxine Supplementation in Patients With Systolic Heart Failure and Subclinical Hypothyroidism Unknown status NCT02316743 Phase 4 Levothyroxine supplementation
15 Steroids in the Postoperative Transient Hypoparathyroidism Total Thyroidectomy Unknown status NCT02652884 Phase 4 phosphate and betamethasone acetate, 2 mL.;saline 0.9% NaCl
16 Trial Evaluating Use of Arista in Total Thyroidectomy Unknown status NCT02568085 Phase 4
17 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
18 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
19 Thyroxine Titration Study Unknown status NCT00111735 Phase 4 Thyroxine
20 Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study Unknown status NCT01850277 Phase 4 Amiodarone;Pharmacotherapy to slow and control ventricular rate
21 Pasireotide LAR and Pegvisomant Study in Acromegaly Unknown status NCT02668172 Phase 4 Pasireotide LAR 60 mg;Pegvisomant
22 Sildenafil Activates Browning of White Adipose and Improves Insulin Sensitivity Unknown status NCT02524184 Phase 4 sildenafil;placebo
23 AMIOdarone vs. Catheter Ablation for Prevention of Recurrent Symptomatic Atrial Fibrillation Unknown status NCT02341105 Phase 4 Amiodarone
24 Clinical Trial to Evaluate the Efficacy of FITOGYN Versus Placebo on the Vasomotor Symptomatology Associated With Menopause Unknown status NCT01116310 Phase 4 Soy isoflavones (Glycine max L) and red clover extract (Trifolium pretense L);Placebo
25 Effect of Erythropoietin in Refractory Autoimmune Encephalitis Patients Unknown status NCT03004209 Phase 4 Erythropoietin
26 A Prospective, Randomized Trial of Intravenous Pulse Versus Sequential Steroid Therapy for Patients With Graves' Orbitopathy Unknown status NCT01969019 Phase 4 methylprednisolone, prednisone
27 Effect of Higher Doses of Remifentanil on Postoperative Pain in Patients Undergoing Thyroidectomy Unknown status NCT01761149 Phase 4 Remifentanil
28 Percutaneous Laser Ablation in Benign Thyroid Nodules.Long Term Results Completed NCT00858104 Phase 4
29 Thyroid Hormone Replacement for Subclinical Hypothyroidism Completed NCT01660126 Phase 4 Levothyroxine;Placebo
30 Quality of Life, Recombinant TSH (Thyrogen) and Thyroid Cancer Completed NCT00604318 Phase 4 rhTSH
31 Study of Radioiodine (131-I) Uptake Following Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal. Completed NCT00001730 Phase 4 Thyrogen
32 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction Completed NCT02491008 Phase 4 Levothyroxine;Placebo
33 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
34 A Comparison of Patch vs. Pill Estrogen Therapy on Testosterone Levels and Thyroid Tests in Menopausal Women Completed NCT00224094 Phase 4 Premarin® (oral) vs. Alora® (transdermal)
35 The TRUST Trial - CardioVascular Imaging ECHO Completed NCT02832960 Phase 4 Levothyroxine;Placebo
36 The TRUST Study - CardioVascular Imaging IMT Completed NCT02832934 Phase 4 Levothyroxine;Placebo
37 Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
38 Thyroid Medication and Antidepressants for Treating Major Depression Completed NCT00208702 Phase 4 Triiodothyronine;Sertraline
39 Antithyroid Drugs During Radioiodine Therapy Completed NCT00150137 Phase 4 Methimazole
40 Block-replacement Therapy During Radioiodine Therapy Completed NCT00150124 Phase 4 MTZ+LT4;Methimazole
41 Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial Completed NCT00520338 Phase 4 celecoxib
42 The Effect of Metformin Treatment on Thyroid Hormone Metabolism in Euthyroid Patients With Type 2 Diabetes Mellitus Completed NCT00463502 Phase 4 Metformin
43 Study to Verify Clinical Utility of Point-of-Care (POC) Thyroid Stimulating Hormone (TSH) Test Kits as Compared to Third Generation TSH Test Kit Completed NCT01921452 Phase 4
44 The TRUST Study - Depression Substudy Completed NCT01853579 Phase 4 Levothyroxine;Placebo
45 Is the Routine Pressure Dressing After Thyroidectomy Necessary? Completed NCT00400465 Phase 4
46 Effects of N-acetylcysteine on Low T3 Syndrome Completed NCT01501110 Phase 4 N-acetylcysteine
47 Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia Completed NCT01308320 Phase 4 fentanyl citrate;saline
48 Neurocognitive and Metabolic Effects of Mild Hypothyroidism Completed NCT00565864 Phase 4 L-thyroxine (L-T4)
49 Effects of L-carnitine on Hypothyroidism Completed NCT01769157 Phase 4 L-carnitine;Placebo
50 Growth Hormone and GnRH Agonist in Adolescents With Acquired Hypothyroidism Completed NCT00206375 Phase 4 Growth hormone;Growth hormone treatment and puberty

Search NIH Clinical Center for Thyroid Gland Disease

Cochrane evidence based reviews: thyroid diseases

Genetic Tests for Thyroid Gland Disease

Genetic tests related to Thyroid Gland Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Thyroid Gland 29

Anatomical Context for Thyroid Gland Disease

MalaCards organs/tissues related to Thyroid Gland Disease:

41
Thyroid, Lung, Ovary, Pituitary, T Cells, Myeloid, Cortex

The Foundational Model of Anatomy Ontology organs/tissues related to Thyroid Gland Disease:

19
The Thyroid

Publications for Thyroid Gland Disease

Articles related to Thyroid Gland Disease:

# Title Authors Year
1
Multi-immunoreaction-based dual-color capillary electrophoresis for enhanced diagnostic reliability of thyroid gland disease. ( 28645753 )
2017
2
Cost-of-Illness Trend of Thyroid Gland Disease in Korea. ( 25309782 )
2014
3
Modern concepts of preoperative preparation of patients with thyroid gland disease. ( 21879658 )
2011
4
Localized crossed hyperhidrosis and the coexistence of thyroid gland disease. ( 20536672 )
2010
5
Application of thermography for non-invasive diagnosis of thyroid gland disease. ( 18334410 )
2008
6
Methodology of the thyroid gland disease decision-making using profiling in steroid hormone pathway. ( 17081718 )
2007
7
[Classification of thyroid gland disease on the basis of selenium concentration in serum]. ( 18246662 )
2007
8
Indications for surgery in thyroid gland disease. ( 13612484 )
1958

Variations for Thyroid Gland Disease

ClinVar genetic disease variations for Thyroid Gland Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 COL7A1 NM_000094.3(COL7A1): c.1442G> A (p.Arg481His) single nucleotide variant Likely pathogenic rs147040026 GRCh38 Chromosome 3, 48591738: 48591738
2 COL7A1 NM_000094.3(COL7A1): c.1442G> A (p.Arg481His) single nucleotide variant Likely pathogenic rs147040026 GRCh37 Chromosome 3, 48629171: 48629171

Expression for Thyroid Gland Disease

Search GEO for disease gene expression data for Thyroid Gland Disease.

Pathways for Thyroid Gland Disease

GO Terms for Thyroid Gland Disease

Biological processes related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.92 FOXE1 NCOA4 NKX2-1 PAX8 RET
2 cell-cell signaling GO:0007267 9.8 CALCA TRH TSHB TSHR
3 anatomical structure morphogenesis GO:0009653 9.71 FOXE1 PAX8 TSHB
4 hormone-mediated signaling pathway GO:0009755 9.56 THRB TRH TSHB TSHR
5 response to pain GO:0048265 9.55 CALCA RET
6 retinal cone cell development GO:0046549 9.51 DIO3 THRB
7 hormone biosynthetic process GO:0042446 9.5 DIO3 TG TPO
8 thyroid hormone metabolic process GO:0042403 9.48 DIO3 TG
9 cellular response to gonadotropin stimulus GO:0071371 9.46 PAX8 SLC5A5
10 negative regulation of eye photoreceptor cell development GO:0042480 9.43 DIO3 THRB
11 retinal cone cell apoptotic process GO:0097474 9.4 DIO3 THRB
12 thyroid-stimulating hormone signaling pathway GO:0038194 9.37 PAX8 TSHR
13 iodide transport GO:0015705 9.33 SLC26A4 SLC5A5 TG
14 thyroid hormone generation GO:0006590 9.26 DIO3 FOXE1 SLC5A5 TPO
15 thyroid gland development GO:0030878 9.02 FOXE1 NKX2-1 PAX8 TG THRB

Molecular functions related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.26 CALCA TG TRH TSHB
2 iodide transmembrane transporter activity GO:0015111 9.16 SLC26A4 SLC5A5
3 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Thyroid Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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