MCID: THY030
MIFTS: 51

Thyroid Gland Disease

Categories: Endocrine diseases

Aliases & Classifications for Thyroid Gland Disease

MalaCards integrated aliases for Thyroid Gland Disease:

Name: Thyroid Gland Disease 12 15
Abnormality of the Thyroid Gland 29 6
Thyroid Diseases 43 71

Classifications:



External Ids:

Disease Ontology 12 DOID:50
MeSH 43 D013959
NCIt 49 C26893
SNOMED-CT 67 14304000
ICD10 32 E00-E07 E07.9
UMLS 71 C0040128

Summaries for Thyroid Gland Disease

Disease Ontology : 12 An endocrine system disease that is located in the thyroid.

MalaCards based summary : Thyroid Gland Disease, also known as abnormality of the thyroid gland, is related to goiter and graves disease 1. An important gene associated with Thyroid Gland Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are DNA Damage Response and MicroRNAs in cancer. The drugs Nitroprusside and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and lymph node.

Related Diseases for Thyroid Gland Disease

Diseases related to Thyroid Gland Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 765)
# Related Disease Score Top Affiliating Genes
1 goiter 33.5 TSHR TG RET CALCA
2 graves disease 1 33.4 TSHR TG CALCA
3 hyperthyroidism 33.1 TSHR TG CALCA
4 multinodular goiter 31.9 TSHR TG MIR222 MIR138-1 CALCA
5 thyroid cancer, nonmedullary, 1 31.6 MIR222 MIR221 MIR146A
6 thyroiditis 31.6 TSHR TG RET CALCA
7 thyroid carcinoma 31.5 TSHR TG RET CALCA
8 differentiated thyroid carcinoma 31.4 TSHR TG RET
9 thyroid gland medullary carcinoma 31.4 TG RET MIR183 CALCA
10 thyroid carcinoma, familial medullary 31.4 TG RET CALCA
11 thyroid gland papillary carcinoma 31.2 TG RET MIR9-1 MIR30A MIR222 MIR221
12 papillary carcinoma 31.2 TSHR TG RET CALCA
13 follicular adenoma 31.1 TSHR TG RET MIR221 CALCA
14 hashimoto thyroiditis 31.1 TSHR TG RET MIR125A CALCA
15 toxic diffuse goiter 31.1 TSHR TG
16 nodular goiter 31.0 TSHR TG RET MIR199A1 CALCA
17 thyroid crisis 30.9 TSHR TG
18 breast cancer 30.9 MIR9-1 MIR30A MIR222 MIR221 MIR21 MIR199A1
19 papillary thyroid microcarcinoma 30.9 TSHR TG CALCA
20 systemic scleroderma 30.9 MIR30A MIR21 H2AC18 CCR6
21 thyroid cancer, nonmedullary, 2 30.9 TSHR TG CALCA
22 bone resorption disease 30.9 MIR222 MIR199A1 H2AC18 CCR6 CALCA
23 thyroid gland cancer 30.9 TSHR TG RET MIR9-1 MIR30A MIR222
24 endemic goiter 30.8 TSHR TG CALCA
25 nontoxic goiter 30.8 TSHR TG CALCA
26 mental depression 30.8 MIR9-1 MIR183 MIR144 H2AC18
27 postsurgical hypothyroidism 30.8 TSHR TG
28 connective tissue disease 30.8 MIR9-1 MIR30A MIR222 MIR221 MIR21 MIR199A1
29 eye disease 30.7 TSHR MIR9-1 MIR30A MIR21 MIR199A1 MIR181A1
30 neonatal thyrotoxicosis 30.7 TSHR TG
31 oral squamous cell carcinoma 30.7 MIR9-1 MIR221 MIR21 MIR199A1 MIR181A1 MIR17
32 thyroid gland follicular carcinoma 30.7 TSHR TG RET MIR9-1 MIR222 MIR183
33 skin disease 30.7 MIR21 MIR199A1 MIR17 MIR125A H2AC18 CCR6
34 vascular disease 30.7 MIR221 MIR21 MIR199A1 MIR146A MIR125A
35 acute thyroiditis 30.6 TG CALCA
36 exanthem 30.6 RET H2AC18 CCR6
37 breast disease 30.5 MIR9-1 MIR30A MIR222 MIR221 MIR21 MIR199A1
38 thyroid gland anaplastic carcinoma 30.5 TG RET MIR30A MIR17
39 body mass index quantitative trait locus 11 30.5 MIR9-1 MIR222 MIR21 MIR199A1 MIR181A1 MIR17
40 dermatomyositis 30.4 MIR30A MIR222 MIR221 MIR21 MIR146B
41 testicular disease 30.4 MIR199A1 MIR181A1 H2AC18 CCR6
42 gastric cancer 30.4 MIR9-1 MIR222 MIR221 MIR21 MIR199A1 MIR17
43 fetal adenoma 30.4 TG CALCA
44 digeorge syndrome 30.4 MIR9-1 MIR183 MIR17 H2AC18
45 hypothyroidism, congenital, nongoitrous, 2 30.4 TSHR TG
46 heart valve disease 30.4 MIR21 MIR199A1 MIR146A
47 leukemia, acute myeloid 30.4 MIR9-1 MIR30A MIR222 MIR221 MIR21 MIR199A1
48 hypoadrenalism 30.3 TG CALCA
49 idiopathic interstitial pneumonia 30.3 MIR21 MIR199A1 CCR6
50 pulmonary disease, chronic obstructive 30.3 MIR199A1 MIR144 H2AC18 CCR6

Comorbidity relations with Thyroid Gland Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential Hypothyroidism

Graphical network of the top 20 diseases related to Thyroid Gland Disease:



Diseases related to Thyroid Gland Disease

Symptoms & Phenotypes for Thyroid Gland Disease

Drugs & Therapeutics for Thyroid Gland Disease

Drugs for Thyroid Gland Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 392)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
2
Nitric Oxide Approved Phase 4 10102-43-9 145068
3
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
4
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
5
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
6
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
7
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
8
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
9
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
10
Acetaminophen Approved Phase 4 103-90-2 1983
11
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
12
Codeine Approved, Illicit Phase 4 76-57-3 5284371
13 Vasodilator Agents Phase 4
14 Nitric Oxide Donors Phase 4
15 Adrenergic alpha-2 Receptor Agonists Phase 4
16 Hypnotics and Sedatives Phase 4
17 Hypolipidemic Agents Phase 4
18 Gastrointestinal Agents Phase 4
19 Lipid Regulating Agents Phase 4
20 Central Nervous System Depressants Phase 4
21 Tranquilizing Agents Phase 4
22 Psychotropic Drugs Phase 4
23 Triamcinolone diacetate Phase 4
24 triamcinolone acetonide Phase 4
25 glucocorticoids Phase 4
26 Triamcinolone hexacetonide Phase 4
27 Technetium Tc 99m Medronate Phase 4
28 Dopamine Agents Phase 4
29 Anticholesteremic Agents Phase 4
30 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
31 Carboxymethylcellulose Sodium Phase 4
32 Cathartics Phase 4
33 Laxatives Phase 4
34 Serotonin Agents Phase 4
35 Red yeast rice Phase 4
36 Red Yeast Phase 4
37 Platelet Aggregation Inhibitors Phase 4
38 policosanol Phase 4
39 Antipsychotic Agents Phase 4
40 Dopamine Antagonists Phase 4
41 Serotonin Antagonists Phase 4
42 Protective Agents Phase 4
43 Narcotics Phase 4
44 Antipyretics Phase 4
45 Antitussive Agents Phase 4
46 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
47 Adjuvants, Immunologic Phase 4
48 Viscosupplements Phase 4
49 Proxymetacaine Phase 4
50
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202

Interventional clinical trials:

(show top 50) (show all 639)
# Name Status NCT ID Phase Drugs
1 Does Sodium Nitroprusside Infusion Affect Thyroidal Function in Patients Undergoing Coronary Artery Bypass Grafting, a Prospective Randomized Clinical Trial. Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
2 Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
3 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
4 Efficacy of Dexmedetomidine for Cough Suppression During Anesthetic Emergence in Patients Undergoing Thyroid Surgery: A Randomized, Double Blinded, Controlled Trial Unknown status NCT03312413 Phase 4 Dexmedetomidine Hydrochloride;Normal Saline;Dexmedetomidine Hydrochloride;Dexmedetomidine Hydrochloride
5 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
6 An International, Randomised, Double-Blind, Two-Arm Study To Evaluate The Safety And Efficacy Of Vandetanib 150 And 300mg/Day In Patients With Unresectable Locally Advanced Or Metastatic Medullary Thyroid Carcinoma With Progressive Or Symptomatic Disease Unknown status NCT01496313 Phase 4 300mg vandetanib;150mg vandetanib
7 The Use of Lu177 in the Treatment of Progressive and Unresectable Metastatic Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
8 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Unknown status NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
9 A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy. Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
10 Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study Completed NCT00400465 Phase 4
11 Is it Possible to Increase Quality of Life, Using Recombinant TSH Instead of Withdrawal of Thyroid Hormone Treatment, Before Iodine Uptake in Patients With Thyroid Cancer? Completed NCT00604318 Phase 4 rhTSH
12 Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results Completed NCT00858104 Phase 4
13 A Dosimetry Study of Radioiodine (131-I) Uptake Following the Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal Completed NCT00001730 Phase 4 Thyrogen
14 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
15 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment Completed NCT02491008 Phase 4 Levothyroxine;Placebo
16 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
17 Impact of Thyroid Hormone Replacement on Cardiac Function: a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism Completed NCT02832960 Phase 4 Levothyroxine;Placebo
18 Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism. Completed NCT02832934 Phase 4 Levothyroxine;Placebo
19 Long Term Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols and Berberine) in Low-moderate Risk Hypercholesterolemic Patients: a Double-blind, Placebo Controlled Study Completed NCT02078167 Phase 4
20 Risperidone Augmentation for Treatment-Resistant Aggression in ADHD Completed NCT00297739 Phase 4 Risperidone
21 Prospective Single Arm Post Marketing Phase IV Study to Assess the Safety and Efficacy of Lenvatinib in Subjects With Locally Recurrent or Metastatic, Progressive, Radioiodine Refractory Differentiated Thyroid Cancer Recruiting NCT03573960 Phase 4 Lenvatinib
22 A Randomized, Double-blind Study To Evaluate the Efficacy and Safety of Cabozantinib (XL184) at 60 mg/Day Compared to a 140 mg/Day in Progressive, Metastatic Medullary Thyroid Cancer Patients Recruiting NCT01896479 Phase 4 Cabozantinib (XL184) 140 mg;Cabozantinib (XL184) 60 mg;Placebo tablet;Placebo capsule
23 Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment Recruiting NCT03969108 Phase 4 Indocyanine Green
24 Minimizing Narcotic Analgesics After Thyroid or Parathyroid Surgery Recruiting NCT03469310 Phase 4 Acetaminophen 500Mg Cap;Tylenol #3 Oral Tablet;Tramadol
25 Phase IV Study of Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Recruiting NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
26 Effects of Long-term L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Patients With Hypothyroidism Active, not recruiting NCT01848171 Phase 4 L-thyroxine
27 The Beneficial Effect of L-Thyroxine Long -Term Replacement on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism: A Prospective Study Active, not recruiting NCT01831869 Phase 4 L-thyroxine
28 Levothyroxine Replacement With Liquid Gel Capsules or Tablets in Post-thyroidectomy Stage in Low Risk Differentiated Thyroid Cancer Patients Active, not recruiting NCT02946918 Phase 4 Levothyroxine
29 The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients. Withdrawn NCT01927406 Phase 4 Prostaglandin Analog;Timolol
30 Medico-economic Evaluation Comparing the Use of Ultrasonic Scissors to the Conventional Techniques of Haemostasis in Thyroid Surgery by Cervicotomy Unknown status NCT01551914 Phase 3
31 Ultrasound Guided Interstitial Laser Photocoagulation on Benign Thyroid Nodules Unknown status NCT00150150 Phase 3
32 Medico-Economic Comparison of Four Strategies of Radioiodine Ablation in Thyroid Carcinoma Patients - Estimabl Unknown status NCT00435851 Phase 3 Thyrogen, thyroid hormone withdrawal, iode 131
33 "ShearWave" Elastography Interest in the Management of Thyroid Nodules Completed NCT01335828 Phase 2, Phase 3
34 Efficacy of Subfascial Approach in Thyroidectomy to Quality of Life in Thyroid Disease Patients: Prospective Randomized Study Completed NCT01616316 Phase 2, Phase 3
35 A Randomized, Double-blind, Placebo-controlled, Multicenter Clinical Trial to Compare the Efficacy and Safety of Anlotinib Versus Placebo in Patients With Medullary Thyroid Carcinoma(ALTER01031) Completed NCT02586350 Phase 2, Phase 3 Anlotinib;Placebo
36 Preoperative Single-dose Steroid Application for the Treatment of Nausea and Vomiting After Thyroid Surgery Completed NCT01189292 Phase 3 Dexamethasone
37 Prospective, Randomized, Double Blind, Multicenter Study for Hyalobarrier ® to Evaluate Anti-adhesive Effect and Safety Compared to Guardix-SG® After Thyroidectomy Completed NCT01696305 Phase 3
38 Phase 3 Study of Treatment of Soft Tissue Expansion and Exophthalmos in Inactive Thyroid Eye Disease Patients Using Drops of Prostaglandin Analogues. Completed NCT02155049 Phase 3 bimatoprost 0.03%
39 Prophylactic Central Lymph Node Dissection in Papillary Thyroid Microcarcinoma: A Prospective Randomized Controlled Trial Completed NCT00795782 Phase 3
40 Impact and Cost Efficiency of Bilateral, Superficial Cervical Block in Thyroid Surgery Under General Anesthesia Completed NCT00472446 Phase 2, Phase 3 bilateral superficial cervical block;placebo bilateral superficial cervical block
41 A Double-Blind Randomized Phase III Study Evaluating the Efficacy and Safety of Sorafenib Compared to Placebo in Locally Advanced/Metastatic RAI-Refractory Differentiated Thyroid Cancer Completed NCT00984282 Phase 3 Sorafenib (Nexavar, BAY43-9006);Placebo
42 Value of Sentinel Lymph Node Biopsy to Lateral Neck Lymph Node in Thyroid Carcinoma: Prospective Study Completed NCT01137097 Phase 2, Phase 3
43 Thyroid Nodules Treated With Percutaneous Radiofrequency Thermal Ablation: a Comparative Study Completed NCT01649206 Phase 3
44 Clinical Trial Phase III, Parallel Group, Randomized, Placebo-controlled, Double-blind, Multicenter Study to Evaluate the Efficacy and Safety of Tocilizumab Administration in Patients With Moderate-to-severe or Sight-threatening Graves' Ophthalmopathy (GO), That Had Not Responded Adequately to Treatment With Intravenous Corticoid Pulses. Completed NCT01297699 Phase 3 Tocilizumab (RoActemra®);Sterile 0.9% Sodium Chloride
45 Follow-up of Thyroid Cancer Patients From Study THYR-008-00 Who Received Thyroid Remnant Ablation Using Either the Hypothyroid or the Thyrogen Method. Completed NCT00295763 Phase 3 Thyrogen (thyrotropin alfa for injection)
46 The Role of Sentinel Lymph Node Biopsy (SLNB) In the Management of Differentiated Thyroid Cancer Completed NCT00794053 Phase 3
47 A Randomized, Controlled, Open-Label, Multi-National Pilot Study of Thyroid Remnant Ablation Comparing the Safety and Ablation Rate Following 131I Administration Using Thyrogen® Versus the Safety and Ablation Rate Following 131I Administration in the Hypothyroid State Completed NCT00196729 Phase 3 Thyrogen + Radioiodine (131I)
48 A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial of Lenvatinib (E7080) in 131I-Refractory Differentiated Thyroid Cancer Completed NCT01321554 Phase 3 Lenvatinib;Placebo;Lenvatinib
49 Effectiveness of Salbutamol Administration by Nebulizer Versus Metered Dose Inhaler With Spacer in Acute Asthma in Children in Suez Canal University Hospital Emergency Department: A Randomized Control Trial Completed NCT03816267 Phase 3 Salbutamol
50 Phase 3 Trial of Adjuvant External Beam Radiotherapy for Locally Invasive Differentiated Thyroid Carcinoma Completed NCT00144079 Phase 3

Search NIH Clinical Center for Thyroid Gland Disease

Cochrane evidence based reviews: thyroid diseases

Genetic Tests for Thyroid Gland Disease

Genetic tests related to Thyroid Gland Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Thyroid Gland 29

Anatomical Context for Thyroid Gland Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Thyroid Gland Disease:

19
Thyroid

MalaCards organs/tissues related to Thyroid Gland Disease:

40
Thyroid, Testes, Lymph Node, Eye, Bone, Breast, T Cells

Publications for Thyroid Gland Disease

Articles related to Thyroid Gland Disease:

(show top 50) (show all 4694)
# Title Authors PMID Year
1
Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population. 61
31846617 2020
2
Graves' disease and mental disorders. 61
31763175 2020
3
Structural studies of thyroid peroxidase show the monomer interacting with autoantibodies in thyroid autoimmune disease. 61
32022847 2020
4
Decreased immunoglobulin G core fucosylation, a player in antibody-dependent cell-mediated cytotoxicity, is associated with autoimmune thyroid diseases. 61
32024769 2020
5
Suspicious ultrasound characteristics correlate with multiple factors that predict central lymph node metastasis of papillary thyroid carcinoma: Significant role of HBME-1. 61
31918249 2020
6
Degree of technical difficulty of thyroidectomy for autoimmune thyroid disease. 61
31651072 2020
7
Impact of total thyroidectomy on quality of life at 6 months: the prospective ThyrQoL multicentre trial. 61
31804967 2020
8
Increases of CD80 and CD86 Expression on Peripheral Blood Cells and their Gene Polymorphisms in Autoimmune Thyroid Disease. 61
31755324 2020
9
Association of CD58 Polymorphisms and its Protein Expression with the Development and Prognosis of Autoimmune Thyroid Diseases. 61
31505972 2020
10
Lower proportion of CD19+IL-10+ and CD19+CD24+CD27+ but not CD1d+CD5+CD19+CD24+CD27+ IL-10+ B cells in children with autoimmune thyroid diseases. 61
31790305 2020
11
Association between mixture of persistent organic pollutants and thyroid pathologies in a Belgian population. 61
31759644 2020
12
Thyroid Dose Estimates for a Cohort of Belarusian Persons Exposed in Utero and During Early Life to Chernobyl Fallout. 61
31869316 2020
13
A review of thyroid gland segmentation and thyroid nodule segmentation methods for medical ultrasound images. 61
31955006 2020
14
Association between Sudden Sensorineural Hearing Loss and Preexisting Thyroid Diseases: A Nationwide Case-Control Study in Taiwan. 61
32013113 2020
15
Upregulation of HLA Class I and Antiviral Tissue Responses in Hashimoto's Thyroiditis. 61
31910110 2020
16
[Association of related maternal factors with susceptibility to congenital hypothyroidism: a case-control study]. 61
31948522 2020
17
Long-term outcomes of graves disease in children treated with anti-thyroid drugs. 61
31980413 2020
18
The detection of serum IgM to thyroglobulin in subacute thyroiditis suggests a protective role of IgM in thyroid autoimmunity. 61
31996918 2020
19
Sex-specific differences in chronic thromboembolic pulmonary hypertension. Results from the European CTEPH registry. 61
31479557 2020
20
Association of cytokine Th2 gene polymorphisms with autoimmune thyroid diseases in Tunisian population. 61
31900992 2020
21
Subclinical Hypothyroidism Is Associated with Lower Ovarian Reserve in Women Aged 35 Years or Older. 61
31650898 2020
22
Iodine concentration and content measured by dual-source computed tomography are correlated to thyroid hormone levels in euthyroid patients: a cross-sectional study in China. 61
32005176 2020
23
Reference intervals for thyroid-stimulating hormone and thyroid hormones using the access TSH 3rd IS method in China. 61
31912542 2020
24
GPER1 in the thyroid: A systematic review. 61
31790688 2020
25
Falsely undetectable TSH in a euthyroid patient. 61
32021655 2020
26
Palmoplantar pustulosis: Factors causing and influencing the course of the disease. 61
31990461 2020
27
Detection of Selenocysteine with a Ratiometric near-Infrared Fluorescent Probe in Cells and in Mice Thyroid Diseases Model. 61
31815453 2020
28
Risk Factors for Dry Eye in Mainland China: A Multi-Center Cross-Sectional Hospital-Based Study. 61
31218906 2019
29
Preoperative ultrasound evaluation of laterocervical lymph nodes: timing and experience modify the treatment of patients with differentiated thyroid cancer. 61
30604043 2019
30
Establishing thresholds and effects of gender, age, and season for thyroglobulin and thyroid peroxidase antibodies by mining real-world big data. 61
31476287 2019
31
Safety and Cost-effectiveness of LigaSure® in Total Thyroidectomy in Comparison with Conventional Suture Tie Technique. 61
31938650 2019
32
Presence of B19V in Patients with Thyroid Gland Disorders. 61
31817247 2019
33
The aggregation between AITD with rheumatologic, or dermatologic, autoimmune diseases. 61
31932147 2019
34
Integrated miRNA and mRNA expression profiling identifies novel targets and pathological mechanisms in autoimmune thyroid diseases. 61
31735554 2019
35
Helicobacter pylori Infection and Autoimmune Thyroid Diseases: The Role of Virulent Strains. 61
31906000 2019
36
Rapid cycling bipolar disorder is associated with antithyroid antibodies, instead of thyroid dysfunction. 61
31791284 2019
37
The impact of thyroid diseases starting from birth on reproductive function. 61
31734887 2019
38
Persistent pollutants: focus on perfluorinated compounds and kidney. 61
31524719 2019
39
Low prevalence of symptomatic thyroid diseases and thyroid cancers in HIV-infected patients. 61
31857648 2019
40
Prevalence of thyroid diseases in the population of the town of Piekary Śląskie in the years 2006-2011 on the basis of the implemented prevention program. 61
31945021 2019
41
Associations of gene polymorphisms in interferon-alpha signature-related genes with autoimmune thyroid diseases. 61
31494956 2019
42
Different expression profile of mRNA and long noncoding RNA in autoimmune thyroid diseases patients. 61
31452253 2019
43
Urinary Iodine Concentration in a Cohort of Adult Outpatients with Thyroid Diseases in Liguria 14 Years after the Law on Salt Iodization. 61
31861566 2019
44
The Diverse Upper Reference Limits of Serum Thyroid-Stimulating Hormone on the Same Platform for Pregnant Women in China. 61
31875892 2019
45
Thyroid Peroxidase Revisited - What's New? 61
31826271 2019
46
Transoral Endoscopic Thyroidectomy by Vestibular Approach-Initial Experience and Comparative Analysis in the First Reported Mexican Cohort. 61
31674869 2019
47
Preliminary study on the efficacy of xerostomia treatment with sialocentesis targeting thyroid disease patients given radioiodine therapy. 61
31544098 2019
48
Effects of acute psychosocial stress on the hypothalamic-pituitary-thyroid (HPT) axis in healthy women. 61
31563038 2019
49
Acute suppurative thyroiditis with thyroid metastasis from esophageal cancer. 61
31681975 2019
50
Association of IL6 gene methylation in peripheral blood cells with the development and prognosis of autoimmune thyroid diseases. 61
31552761 2019

Variations for Thyroid Gland Disease

ClinVar genetic disease variations for Thyroid Gland Disease:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 COL7A1 NM_000094.3(COL7A1):c.1442G>A (p.Arg481His)SNV Likely pathogenic 373954 rs147040026 3:48629171-48629171 3:48591738-48591738

Expression for Thyroid Gland Disease

Search GEO for disease gene expression data for Thyroid Gland Disease.

Pathways for Thyroid Gland Disease

Pathways related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 MIR222 MIR221 MIR181A1 MIR17
2 11.85 MIR9-1 MIR30A MIR222 MIR221 MIR21 MIR199A1
3 11.03 MIR222 MIR221 MIR181A1
4 11.01 MIR9-1 MIR222 MIR221 MIR199A1 MIR181A1 MIR146B
5 10.03 TSHR TG

GO Terms for Thyroid Gland Disease

Cellular components related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.4 MIR30A MIR222 MIR221 MIR21 MIR199A1 MIR183

Biological processes related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10 RET MIR30A MIR21 MIR146A MIR125A
2 positive regulation of cell migration GO:0030335 9.93 RET MIR30A MIR21 MIR181A1
3 cellular response to lipopolysaccharide GO:0071222 9.89 MIR21 MIR17 MIR146B MIR146A
4 negative regulation of gene expression GO:0010629 9.88 MIR21 MIR181A1 MIR17 MIR146A MIR138-1 MIR125A
5 transforming growth factor beta receptor signaling pathway GO:0007179 9.82 MIR30A MIR21 MIR183
6 negative regulation of angiogenesis GO:0016525 9.8 MIR222 MIR21 MIR146A MIR125A
7 negative regulation of inflammatory response GO:0050728 9.77 MIR222 MIR221 MIR181A1 MIR146A MIR138-1
8 positive regulation of G1/S transition of mitotic cell cycle GO:1900087 9.76 MIR30A MIR222 MIR221
9 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.75 MIR221 MIR146B MIR146A
10 positive regulation of epithelial to mesenchymal transition GO:0010718 9.74 MIR222 MIR221 MIR21
11 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.73 MIR222 MIR221 MIR21 MIR17
12 positive regulation of epithelial cell migration GO:0010634 9.72 MIR222 MIR221 CCR6
13 negative regulation of sprouting angiogenesis GO:1903671 9.71 MIR221 MIR17 MIR138-1
14 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.65 MIR199A1 MIR17
15 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.65 MIR21 MIR181A1
16 negative regulation of osteoblast proliferation GO:0033689 9.64 MIR9-1 MIR138-1
17 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.63 MIR199A1 MIR17
18 positive regulation of protein kinase B signaling GO:0051897 9.63 RET MIR222 MIR221 MIR21 MIR199A1 MIR138-1
19 positive regulation of axon regeneration GO:0048680 9.62 MIR222 MIR221
20 positive regulation of metalloendopeptidase activity GO:1904685 9.62 MIR21 MIR17
21 negative regulation by host of viral genome replication GO:0044828 9.61 MIR222 MIR221
22 miRNA mediated inhibition of translation GO:0035278 9.61 MIR9-1 MIR30A MIR222 MIR221 MIR21 MIR181A1
23 regulation of toll-like receptor signaling pathway GO:0034121 9.6 MIR146B MIR146A
24 negative regulation of cell adhesion molecule production GO:0060354 9.56 MIR222 MIR221
25 negative regulation of TRAIL-activated apoptotic signaling pathway GO:1903122 9.52 MIR222 MIR221
26 positive regulation of Schwann cell migration GO:1900149 9.51 MIR222 MIR221
27 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.5 MIR21 MIR17 MIR138-1
28 positive regulation of Schwann cell proliferation involved in axon regeneration GO:1905046 9.48 MIR222 MIR221
29 gene silencing by miRNA GO:0035195 9.47 MIR9-1 MIR30A MIR222 MIR221 MIR21 MIR199A1
30 negative regulation of hematopoietic stem cell proliferation GO:1902034 9.46 MIR222 MIR221
31 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.43 MIR222 MIR221 MIR146A

Molecular functions related to Thyroid Gland Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.47 MIR9-1 MIR30A MIR222 MIR221 MIR21 MIR199A1

Sources for Thyroid Gland Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....