MCID: THY127
MIFTS: 19

Thyroid Gland Hurthle Cell Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Thyroid Gland Hurthle Cell Carcinoma

MalaCards integrated aliases for Thyroid Gland Hurthle Cell Carcinoma:

Name: Thyroid Gland Hurthle Cell Carcinoma 12
Oncocytic Carcinoma of the Thyroid 12
Thyroid Hurthle Cell Carcinoma 15
Thyroid Cancer, Hurthle Cell 44

Classifications:



External Ids:

Disease Ontology 12 DOID:8161
MeSH 44 C536913
NCIt 50 C4946
UMLS 72 C0749424

Summaries for Thyroid Gland Hurthle Cell Carcinoma

Disease Ontology : 12 A thyroid gland follicular carcinoma that is characterized by the presence of large cells with eosinophilic granular cytoplasm and pleomorphic nuclei with prominent, eosinophilic nucleoli.

MalaCards based summary : Thyroid Gland Hurthle Cell Carcinoma, also known as oncocytic carcinoma of the thyroid, is related to thyroid carcinoma, hurthle cell and thyroid carcinoma. An important gene associated with Thyroid Gland Hurthle Cell Carcinoma is TG (Thyroglobulin). The drugs Imetelstat and Motesanib diphosphate have been mentioned in the context of this disorder. Affiliated tissues include thyroid.

Related Diseases for Thyroid Gland Hurthle Cell Carcinoma

Diseases related to Thyroid Gland Hurthle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma, hurthle cell 12.0
2 thyroid carcinoma 10.4
3 thyroid cancer, nonmedullary, 1 10.1
4 thyroid gland papillary carcinoma 10.1
5 adenoma 10.1
6 renal cell carcinoma, nonpapillary 10.0
7 thyroid tumor 10.0

Graphical network of the top 20 diseases related to Thyroid Gland Hurthle Cell Carcinoma:



Diseases related to Thyroid Gland Hurthle Cell Carcinoma

Symptoms & Phenotypes for Thyroid Gland Hurthle Cell Carcinoma

Drugs & Therapeutics for Thyroid Gland Hurthle Cell Carcinoma

Drugs for Thyroid Gland Hurthle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imetelstat Investigational Phase 2 868169-64-6
2
Motesanib diphosphate Phase 2 850649-62-6 11450633
3 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Open-label Study of AMG 706 to Treat Subjects With Locally Advanced or Metastatic Thyroid Cancer Completed NCT00121628 Phase 2 AMG 706

Search NIH Clinical Center for Thyroid Gland Hurthle Cell Carcinoma

Cochrane evidence based reviews: thyroid cancer, hurthle cell

Genetic Tests for Thyroid Gland Hurthle Cell Carcinoma

Anatomical Context for Thyroid Gland Hurthle Cell Carcinoma

MalaCards organs/tissues related to Thyroid Gland Hurthle Cell Carcinoma:

41
Thyroid

Publications for Thyroid Gland Hurthle Cell Carcinoma

Articles related to Thyroid Gland Hurthle Cell Carcinoma:

# Title Authors PMID Year
1
Malignant Solitary Fibrous Tumor Metastatic to Widely Invasive Hurthle Cell Thyroid Carcinoma: A Distinct Tumor-to-Tumor Metastasis. 38
29616597 2018
2
The oncocyte that went places: diagnosis with EUS-guided FNA. 38
21954063 2013
3
Metastatic Hurthle cell carcinoma in the abdomen masquerading as a primary ovarian tumor: a case report. 38
16445671 2006

Variations for Thyroid Gland Hurthle Cell Carcinoma

Cosmic variations for Thyroid Gland Hurthle Cell Carcinoma:

9 (show all 18)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM26419 TSHR thyroid,NS,carcinoma,Hurthle cell carcinoma c.1897G>T p.D633Y 14:81143955-81143955 18
2 COSM26489 TSHR thyroid,NS,carcinoma,Hurthle cell carcinoma c.2029C>G p.L677V 14:81144087-81144087 18
3 COSM14191 SMAD4 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1016T>C p.F339S 18:51065483-51065483 18
4 COSM14190 SMAD4 thyroid,NS,carcinoma,Hurthle cell carcinoma c.992T>C p.M331T 18:51065459-51065459 18
5 COSM775 PIK3CA thyroid,NS,carcinoma,Hurthle cell carcinoma c.3140A>G p.H1047R 3:179234297-179234297 18
6 COSM584 NRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 1:114713908-114713908 18
7 COSM580 NRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.181C>A p.Q61K 1:114713909-114713909 18
8 COSM521 KRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>A p.G12D 12:25245350-25245350 18
9 COSM522 KRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 18
10 COSM6697310 KMT2C thyroid,NS,carcinoma,Hurthle cell carcinoma c.1093C>A p.H365N 7:152265129-152265129 18
11 COSM96531 IDH1 thyroid,NS,carcinoma,Hurthle cell carcinoma c.209G>A p.G70D 2:208248574-208248574 18
12 COSM483 HRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 18
13 COSM499 HRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 18
14 COSM4684537 FGF6 thyroid,NS,carcinoma,Hurthle cell carcinoma c.185G>A p.R62H 12:4445386-4445386 18
15 COSM476 BRAF thyroid,NS,carcinoma,Hurthle cell carcinoma c.1799T>A p.V600E 7:140753336-140753336 18
16 COSM33765 AKT1 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 18
17 COSM1140134 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 18
18 COSM6697309 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1093C>A p.H365N 7:152265129-152265129 18

Expression for Thyroid Gland Hurthle Cell Carcinoma

Search GEO for disease gene expression data for Thyroid Gland Hurthle Cell Carcinoma.

Pathways for Thyroid Gland Hurthle Cell Carcinoma

GO Terms for Thyroid Gland Hurthle Cell Carcinoma

Sources for Thyroid Gland Hurthle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....