MCID: THY127
MIFTS: 21

Thyroid Gland Hurthle Cell Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Thyroid Gland Hurthle Cell Carcinoma

MalaCards integrated aliases for Thyroid Gland Hurthle Cell Carcinoma:

Name: Thyroid Gland Hurthle Cell Carcinoma 12 15
Oncocytic Carcinoma of the Thyroid 12
Thyroid Cancer, Hurthle Cell 43

Classifications:



External Ids:

Disease Ontology 12 DOID:8161
MeSH 43 C536913
NCIt 49 C4946
SNOMED-CT 67 423158009
UMLS 71 C0749424

Summaries for Thyroid Gland Hurthle Cell Carcinoma

Disease Ontology : 12 A thyroid gland follicular carcinoma that is characterized by the presence of large cells with eosinophilic granular cytoplasm and pleomorphic nuclei with prominent, eosinophilic nucleoli.

MalaCards based summary : Thyroid Gland Hurthle Cell Carcinoma, also known as oncocytic carcinoma of the thyroid, is related to thyroid carcinoma, hurthle cell and thyroid carcinoma. An important gene associated with Thyroid Gland Hurthle Cell Carcinoma is SERPINA3 (Serpin Family A Member 3). The drugs Imetelstat and Protein Kinase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include thyroid.

Related Diseases for Thyroid Gland Hurthle Cell Carcinoma

Diseases related to Thyroid Gland Hurthle Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma, hurthle cell 12.1
2 thyroid carcinoma 10.4
3 papillary carcinoma 10.2
4 adenoma 10.1
5 renal cell carcinoma, nonpapillary 10.0
6 thyroid tumor 10.0
7 autoimmune disease of skin and connective tissue 9.6 TG SERPINA3
8 salivary gland disease 9.5 TG SERPINA3
9 endocrine organ benign neoplasm 9.5 TG SERPINA3
10 thyroid gland disease 9.5 TG SERPINA3
11 mucoepidermoid carcinoma 9.4 TG SERPINA3
12 endocrine system disease 9.2 TG SERPINA3

Graphical network of the top 20 diseases related to Thyroid Gland Hurthle Cell Carcinoma:



Diseases related to Thyroid Gland Hurthle Cell Carcinoma

Symptoms & Phenotypes for Thyroid Gland Hurthle Cell Carcinoma

Drugs & Therapeutics for Thyroid Gland Hurthle Cell Carcinoma

Drugs for Thyroid Gland Hurthle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imetelstat Investigational Phase 2 868169-64-6
2 Protein Kinase Inhibitors Phase 2
3
Motesanib diphosphate Phase 2 850649-62-6 11450633

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Open-label Study of AMG 706 to Treat Subjects With Locally Advanced or Metastatic Thyroid Cancer Completed NCT00121628 Phase 2 AMG 706

Search NIH Clinical Center for Thyroid Gland Hurthle Cell Carcinoma

Cochrane evidence based reviews: thyroid cancer, hurthle cell

Genetic Tests for Thyroid Gland Hurthle Cell Carcinoma

Anatomical Context for Thyroid Gland Hurthle Cell Carcinoma

MalaCards organs/tissues related to Thyroid Gland Hurthle Cell Carcinoma:

40
Thyroid

Publications for Thyroid Gland Hurthle Cell Carcinoma

Articles related to Thyroid Gland Hurthle Cell Carcinoma:

# Title Authors PMID Year
1
Correction: Propensity score matching analysis of the prognosis for the rare oxyphilic subtype of thyroid cancer (Hurthle cell carcinoma). 61
29664476 2018
2
Thrombosis in Thyroid Cancer. 61
29696039 2018
3
Propensity score matching analysis of the prognosis for the rare oxyphilic subtype of thyroid cancer (Hurthle cell carcinoma). 61
29254170 2017
4
High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor gene. 61
12364463 2002

Variations for Thyroid Gland Hurthle Cell Carcinoma

Cosmic variations for Thyroid Gland Hurthle Cell Carcinoma:

9 (show all 48)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM131083920 TSHR thyroid,NS,carcinoma,Hurthle cell carcinoma c.1897G>T p.D633Y 14:81143955-81143955 15
2 COSM131092908 TSHR thyroid,NS,carcinoma,Hurthle cell carcinoma c.2029C>G p.L677V 14:81144087-81144087 15
3 COSM91398827 SMAD4 thyroid,NS,carcinoma,Hurthle cell carcinoma c.992T>C p.M331T 18:51065459-51065459 15
4 COSM91398838 SMAD4 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1016T>C p.F339S 18:51065483-51065483 15
5 COSM87132245 PIK3CA thyroid,NS,carcinoma,Hurthle cell carcinoma c.3140A>G p.H1047R 3:179234297-179234297 15
6 COSM97107359 NRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 1:114713908-114713908 15
7 COSM97107326 NRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.181C>A p.Q61K 1:114713909-114713909 15
8 COSM87804083 KRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 15
9 COSM87804005 KRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>A p.G12D 12:25245350-25245350 15
10 COSM88406613 KMT2C thyroid,NS,carcinoma,Hurthle cell carcinoma c.1093C>A p.H365N 7:152265129-152265129 15
11 COSM103037146 IDH1 thyroid,NS,carcinoma,Hurthle cell carcinoma c.209G>A p.G70D 2:208248574-208248574 15
12 COSM112988851 HRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 15
13 COSM112988917 HRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 15
14 COSM84497088 FGF6 thyroid,NS,carcinoma,Hurthle cell carcinoma c.185G>A p.R62H 12:4445386-4445386 15
15 COSM150563774 BRAF thyroid,NS,carcinoma,Hurthle cell carcinoma c.1799T>A p.V600E 7:140753336-140753336 15
16 COSM133535772 AKT1 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 15
17 COSM112756228 thyroid,NS,carcinoma,Hurthle cell carcinoma c.209G>A p.G70D 2:208248574-208248574 15
18 COSM103842060 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 15
19 COSM91331236 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 15
20 COSM149385292 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1919T>A p.V640E 7:140753336-140753336 15
21 COSM148932633 thyroid,NS,carcinoma,Hurthle cell carcinoma c.*220A>G p.? 3:179234297-179234297 15
22 COSM105721467 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 15
23 COSM101967337 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 15
24 COSM88803061 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1919T>A p.V640E 7:140753336-140753336 15
25 COSM91859716 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>A p.G12D 12:25245350-25245350 15
26 COSM85475666 thyroid,NS,carcinoma,Hurthle cell carcinoma c.2029C>G p.L677V 14:81144087-81144087 15
27 COSM134535128 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 15
28 COSM103101228 thyroid,NS,carcinoma,Hurthle cell carcinoma c.992T>C p.M331T 18:51065459-51065459 15
29 COSM101951679 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 15
30 COSM134615025 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 15
31 COSM103101236 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1016T>C p.F339S 18:51065483-51065483 15
32 COSM136349850 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 15
33 COSM90469774 thyroid,NS,carcinoma,Hurthle cell carcinoma c.209G>A p.G70D 2:208248574-208248574 15
34 COSM101967275 thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 15
35 COSM118787231 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1799T>A p.V600E 7:140753336-140753336 15
36 COSM105721394 thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 15
37 COSM89233576 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 15
38 COSM134614922 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>A p.G12D 12:25245350-25245350 15
39 COSM105584865 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 15
40 COSM91331163 thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 15
41 COSM134990112 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>A p.G12D 12:25245350-25245350 15
42 COSM139784562 thyroid,NS,carcinoma,Hurthle cell carcinoma c.704T>C p.M235T 18:51065459-51065459 15
43 COSM90812912 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1093C>A p.H365N 7:152265129-152265129 15
44 COSM139784567 thyroid,NS,carcinoma,Hurthle cell carcinoma c.728T>C p.F243S 18:51065483-51065483 15
45 COSM91859778 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 15
46 COSM101951610 thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 15
47 COSM134990198 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 15
48 COSM85466701 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1897G>T p.D633Y 14:81143955-81143955 15

Expression for Thyroid Gland Hurthle Cell Carcinoma

Search GEO for disease gene expression data for Thyroid Gland Hurthle Cell Carcinoma.

Pathways for Thyroid Gland Hurthle Cell Carcinoma

GO Terms for Thyroid Gland Hurthle Cell Carcinoma

Sources for Thyroid Gland Hurthle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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