MCID: THY127
MIFTS: 24

Thyroid Gland Hurthle Cell Carcinoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Thyroid Gland Hurthle Cell Carcinoma

MalaCards integrated aliases for Thyroid Gland Hurthle Cell Carcinoma:

Name: Thyroid Gland Hurthle Cell Carcinoma 12
Oncocytic Carcinoma of the Thyroid 12
Thyroid Hurthle Cell Carcinoma 15
Thyroid Cancer, Hurthle Cell 43

Classifications:



External Ids:

Disease Ontology 12 DOID:8161
MeSH 43 C536913
NCIt 49 C4946
UMLS 71 C0749424

Summaries for Thyroid Gland Hurthle Cell Carcinoma

Disease Ontology : 12 A thyroid gland follicular carcinoma that is characterized by the presence of large cells with eosinophilic granular cytoplasm and pleomorphic nuclei with prominent, eosinophilic nucleoli.

MalaCards based summary : Thyroid Gland Hurthle Cell Carcinoma, also known as oncocytic carcinoma of the thyroid, is related to thyroid carcinoma, hurthle cell and thyroid carcinoma. An important gene associated with Thyroid Gland Hurthle Cell Carcinoma is SERPINA3 (Serpin Family A Member 3). The drugs Imetelstat and Motesanib diphosphate have been mentioned in the context of this disorder. Affiliated tissues include thyroid and salivary gland, and related phenotype is digestive/alimentary.

Related Diseases for Thyroid Gland Hurthle Cell Carcinoma

Graphical network of the top 20 diseases related to Thyroid Gland Hurthle Cell Carcinoma:



Diseases related to Thyroid Gland Hurthle Cell Carcinoma

Symptoms & Phenotypes for Thyroid Gland Hurthle Cell Carcinoma

MGI Mouse Phenotypes related to Thyroid Gland Hurthle Cell Carcinoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 8.92 AQP4 MOGS SLC5A8 TG

Drugs & Therapeutics for Thyroid Gland Hurthle Cell Carcinoma

Drugs for Thyroid Gland Hurthle Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Imetelstat Investigational Phase 2 868169-64-6
2
Motesanib diphosphate Phase 2 850649-62-6 11450633
3 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2, Open-label Study of AMG 706 to Treat Subjects With Locally Advanced or Metastatic Thyroid Cancer Completed NCT00121628 Phase 2 AMG 706

Search NIH Clinical Center for Thyroid Gland Hurthle Cell Carcinoma

Cochrane evidence based reviews: thyroid cancer, hurthle cell

Genetic Tests for Thyroid Gland Hurthle Cell Carcinoma

Anatomical Context for Thyroid Gland Hurthle Cell Carcinoma

MalaCards organs/tissues related to Thyroid Gland Hurthle Cell Carcinoma:

40
Thyroid, Salivary Gland

Publications for Thyroid Gland Hurthle Cell Carcinoma

Articles related to Thyroid Gland Hurthle Cell Carcinoma:

# Title Authors PMID Year
1
Malignant Solitary Fibrous Tumor Metastatic to Widely Invasive Hurthle Cell Thyroid Carcinoma: A Distinct Tumor-to-Tumor Metastasis. 61
29616597 2018
2
The oncocyte that went places: diagnosis with EUS-guided FNA. 61
21954063 2013
3
Metastatic Hurthle cell carcinoma in the abdomen masquerading as a primary ovarian tumor: a case report. 61
16445671 2006

Variations for Thyroid Gland Hurthle Cell Carcinoma

Cosmic variations for Thyroid Gland Hurthle Cell Carcinoma:

9 (show all 48)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM131083920 TSHR thyroid,NS,carcinoma,Hurthle cell carcinoma c.1897G>T p.D633Y 14:81143955-81143955 18
2 COSM131092908 TSHR thyroid,NS,carcinoma,Hurthle cell carcinoma c.2029C>G p.L677V 14:81144087-81144087 18
3 COSM91398827 SMAD4 thyroid,NS,carcinoma,Hurthle cell carcinoma c.992T>C p.M331T 18:51065459-51065459 18
4 COSM91398838 SMAD4 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1016T>C p.F339S 18:51065483-51065483 18
5 COSM87132245 PIK3CA thyroid,NS,carcinoma,Hurthle cell carcinoma c.3140A>G p.H1047R 3:179234297-179234297 18
6 COSM97107359 NRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 1:114713908-114713908 18
7 COSM97107326 NRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.181C>A p.Q61K 1:114713909-114713909 18
8 COSM87804083 KRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 18
9 COSM87804005 KRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>A p.G12D 12:25245350-25245350 18
10 COSM88406613 KMT2C thyroid,NS,carcinoma,Hurthle cell carcinoma c.1093C>A p.H365N 7:152265129-152265129 18
11 COSM103037146 IDH1 thyroid,NS,carcinoma,Hurthle cell carcinoma c.209G>A p.G70D 2:208248574-208248574 18
12 COSM112988851 HRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 18
13 COSM112988917 HRAS thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 18
14 COSM84497088 FGF6 thyroid,NS,carcinoma,Hurthle cell carcinoma c.185G>A p.R62H 12:4445386-4445386 18
15 COSM150563774 BRAF thyroid,NS,carcinoma,Hurthle cell carcinoma c.1799T>A p.V600E 7:140753336-140753336 18
16 COSM133535772 AKT1 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 18
17 COSM112756228 thyroid,NS,carcinoma,Hurthle cell carcinoma c.209G>A p.G70D 2:208248574-208248574 18
18 COSM103842060 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 18
19 COSM91331236 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 18
20 COSM149385292 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1919T>A p.V640E 7:140753336-140753336 18
21 COSM148932633 thyroid,NS,carcinoma,Hurthle cell carcinoma c.*220A>G p.? 3:179234297-179234297 18
22 COSM105721467 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 18
23 COSM101967337 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 18
24 COSM88803061 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1919T>A p.V640E 7:140753336-140753336 18
25 COSM91859716 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>A p.G12D 12:25245350-25245350 18
26 COSM85475666 thyroid,NS,carcinoma,Hurthle cell carcinoma c.2029C>G p.L677V 14:81144087-81144087 18
27 COSM134535128 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 18
28 COSM103101228 thyroid,NS,carcinoma,Hurthle cell carcinoma c.992T>C p.M331T 18:51065459-51065459 18
29 COSM101951679 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>T p.G12V 11:534288-534288 18
30 COSM134615025 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 18
31 COSM103101236 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1016T>C p.F339S 18:51065483-51065483 18
32 COSM136349850 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 18
33 COSM90469774 thyroid,NS,carcinoma,Hurthle cell carcinoma c.209G>A p.G70D 2:208248574-208248574 18
34 COSM101967275 thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 18
35 COSM118787231 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1799T>A p.V600E 7:140753336-140753336 18
36 COSM105721394 thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 18
37 COSM89233576 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 18
38 COSM134614922 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>A p.G12D 12:25245350-25245350 18
39 COSM105584865 thyroid,NS,carcinoma,Hurthle cell carcinoma c.49G>A p.E17K 14:104780214-104780214 18
40 COSM91331163 thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 18
41 COSM134990112 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>A p.G12D 12:25245350-25245350 18
42 COSM139784562 thyroid,NS,carcinoma,Hurthle cell carcinoma c.704T>C p.M235T 18:51065459-51065459 18
43 COSM90812912 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1093C>A p.H365N 7:152265129-152265129 18
44 COSM139784567 thyroid,NS,carcinoma,Hurthle cell carcinoma c.728T>C p.F243S 18:51065483-51065483 18
45 COSM91859778 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 18
46 COSM101951610 thyroid,NS,carcinoma,Hurthle cell carcinoma c.182A>G p.Q61R 11:533874-533874 18
47 COSM134990198 thyroid,NS,carcinoma,Hurthle cell carcinoma c.35G>C p.G12A 12:25245350-25245350 18
48 COSM85466701 thyroid,NS,carcinoma,Hurthle cell carcinoma c.1897G>T p.D633Y 14:81143955-81143955 18

Expression for Thyroid Gland Hurthle Cell Carcinoma

Search GEO for disease gene expression data for Thyroid Gland Hurthle Cell Carcinoma.

Pathways for Thyroid Gland Hurthle Cell Carcinoma

GO Terms for Thyroid Gland Hurthle Cell Carcinoma

Sources for Thyroid Gland Hurthle Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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