MCID: THY016
MIFTS: 25

Thyroid Hurthle Cell Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Thyroid Hurthle Cell Adenoma

MalaCards integrated aliases for Thyroid Hurthle Cell Adenoma:

Name: Thyroid Hurthle Cell Adenoma 12 15
Benign Oncocytoma of the Thyroid 12
Thyroid Gland Oncocytic Adenoma 74
Hurthle Cell Thyroid Adenoma 30

Classifications:



External Ids:

Disease Ontology 12 DOID:8162
NCIt 51 C6042
UMLS 74 C1336750

Summaries for Thyroid Hurthle Cell Adenoma

MalaCards based summary : Thyroid Hurthle Cell Adenoma, also known as benign oncocytoma of the thyroid, is related to papilloma and ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3. An important gene associated with Thyroid Hurthle Cell Adenoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Development IGF-1 receptor signaling and B cell receptor signaling pathway (KEGG). Affiliated tissues include thyroid, and related phenotypes are adipose tissue and neoplasm

Related Diseases for Thyroid Hurthle Cell Adenoma

Diseases related to Thyroid Hurthle Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 papilloma 9.9 KRT14 PTEN
2 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 9.9 PIK3CA PTEN
3 proteus syndrome 9.9 PIK3CA PTEN
4 lipomatosis 9.9 PIK3CA PTEN
5 ovarian clear cell carcinoma 9.9 PIK3CA PTEN
6 megalencephaly 9.9 PIK3CA PTEN
7 uterine anomalies 9.9 PIK3CA PTEN
8 carcinosarcoma 9.9 PIK3CA PTEN
9 anaplastic thyroid cancer 9.9 PIK3CA PTEN
10 respiratory system cancer 9.9 PIK3CA PTEN
11 uterine carcinosarcoma 9.9 PIK3CA PTEN
12 renal cell carcinoma, papillary, 1 9.9 PIK3CA PTEN
13 oral cavity cancer 9.8 PIK3CA PTEN
14 breast squamous cell carcinoma 9.8 KRT14 PIK3CA
15 breast adenomyoepithelioma 9.8 KRT14 PIK3CA
16 gastrointestinal system cancer 9.8 PIK3CA PTEN
17 breast myoepithelial neoplasm 9.8 KRT14 PIK3CA
18 pregnancy adenoma 9.8 KRT14 PIK3CA
19 suppression of tumorigenicity 12 9.8 PIK3CA PTEN
20 breast adenocarcinoma 9.8 PIK3CA PTEN
21 adenocarcinoma 9.8 PIK3CA PTEN
22 thyroid cancer, nonmedullary, 2 9.8 PIK3CA PTEN
23 small cell cancer of the lung 9.8 PIK3CA PTEN
24 melanoma, cutaneous malignant 1 9.8 PIK3CA PTEN
25 adamantinoma of long bones 9.8 PIK3CA PTEN
26 lung squamous cell carcinoma 9.7 PIK3CA PTEN
27 cholangiocarcinoma 9.7 PIK3CA PTEN
28 glioblastoma multiforme 9.7 PIK3CA PTEN
29 squamous cell carcinoma, head and neck 9.6 PIK3CA PTEN
30 adenoid cystic carcinoma 9.5 KRT14 PIK3CA PTEN
31 cervical cancer 9.5 KRT14 PIK3CA PTEN
32 large intestine cancer 9.5 PIK3CA PTEN

Graphical network of the top 20 diseases related to Thyroid Hurthle Cell Adenoma:



Diseases related to Thyroid Hurthle Cell Adenoma

Symptoms & Phenotypes for Thyroid Hurthle Cell Adenoma

MGI Mouse Phenotypes related to Thyroid Hurthle Cell Adenoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.33 KRT14 PIK3CA PTEN
2 neoplasm MP:0002006 9.13 KRT14 PIK3CA PTEN
3 vision/eye MP:0005391 8.8 KRT14 PIK3CA PTEN

Drugs & Therapeutics for Thyroid Hurthle Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Thyroid Hurthle Cell Adenoma

Genetic Tests for Thyroid Hurthle Cell Adenoma

Genetic tests related to Thyroid Hurthle Cell Adenoma:

# Genetic test Affiliating Genes
1 Hurthle Cell Thyroid Adenoma 30

Anatomical Context for Thyroid Hurthle Cell Adenoma

MalaCards organs/tissues related to Thyroid Hurthle Cell Adenoma:

42
Thyroid

Publications for Thyroid Hurthle Cell Adenoma

Variations for Thyroid Hurthle Cell Adenoma

Expression for Thyroid Hurthle Cell Adenoma

Search GEO for disease gene expression data for Thyroid Hurthle Cell Adenoma.

Pathways for Thyroid Hurthle Cell Adenoma

Pathways related to Thyroid Hurthle Cell Adenoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12 PIK3CA PTEN
2
Show member pathways
11.98 PIK3CA PTEN
3
Show member pathways
11.95 PIK3CA PTEN
4
Show member pathways
11.92 PIK3CA PTEN
5
Show member pathways
11.84 PIK3CA PTEN
6
Show member pathways
11.8 PIK3CA PTEN
7
Show member pathways
11.77 PIK3CA PTEN
8 11.76 PIK3CA PTEN
9 11.74 PIK3CA PTEN
10
Show member pathways
11.73 PIK3CA PTEN
11
Show member pathways
11.7 PIK3CA PTEN
12
Show member pathways
11.66 PIK3CA PTEN
13 11.62 PIK3CA PTEN
14 11.57 PIK3CA PTEN
15 11.54 PIK3CA PTEN
16
Show member pathways
11.5 PIK3CA PTEN
17 11.4 PIK3CA PTEN
18 11.37 PIK3CA PTEN
19 11.19 PIK3CA PTEN
20 11.13 PIK3CA PTEN
21 10.99 PIK3CA PTEN
22 10.89 PIK3CA PTEN
23 10.57 PIK3CA PTEN
24 10.1 PIK3CA PTEN

GO Terms for Thyroid Hurthle Cell Adenoma

Biological processes related to Thyroid Hurthle Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.37 PIK3CA PTEN
2 cell migration GO:0016477 9.32 PIK3CA PTEN
3 aging GO:0007568 9.26 KRT14 PTEN
4 protein kinase B signaling GO:0043491 9.16 PIK3CA PTEN
5 endothelial cell migration GO:0043542 8.96 PIK3CA PTEN
6 response to zinc ion GO:0010043 8.62 KRT14 PTEN

Sources for Thyroid Hurthle Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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