MCID: THY016
MIFTS: 22

Thyroid Hurthle Cell Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Thyroid Hurthle Cell Adenoma

MalaCards integrated aliases for Thyroid Hurthle Cell Adenoma:

Name: Thyroid Hurthle Cell Adenoma 12 15
Benign Oncocytoma of the Thyroid 12
Thyroid Gland Oncocytic Adenoma 72

Classifications:



External Ids:

Disease Ontology 12 DOID:8162
NCIt 50 C6042
UMLS 72 C1336750

Summaries for Thyroid Hurthle Cell Adenoma

MalaCards based summary : Thyroid Hurthle Cell Adenoma, also known as benign oncocytoma of the thyroid, is related to papilloma and ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3. An important gene associated with Thyroid Hurthle Cell Adenoma is KRT14 (Keratin 14), and among its related pathways/superpathways are Development IGF-1 receptor signaling and B cell receptor signaling pathway (KEGG). Affiliated tissues include thyroid, and related phenotypes are adipose tissue and neoplasm

Related Diseases for Thyroid Hurthle Cell Adenoma

Diseases related to Thyroid Hurthle Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 papilloma 9.9 PTEN KRT14
2 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 9.8 PTEN PIK3CA
3 proteus syndrome 9.8 PTEN PIK3CA
4 lipomatosis 9.8 PTEN PIK3CA
5 ovarian clear cell carcinoma 9.8 PTEN PIK3CA
6 megalencephaly 9.8 PTEN PIK3CA
7 uterine anomalies 9.8 PTEN PIK3CA
8 carcinosarcoma 9.8 PTEN PIK3CA
9 respiratory system cancer 9.8 PTEN PIK3CA
10 uterine carcinosarcoma 9.8 PTEN PIK3CA
11 renal cell carcinoma, papillary, 1 9.8 PTEN PIK3CA
12 oral cavity cancer 9.8 PTEN PIK3CA
13 breast squamous cell carcinoma 9.7 PIK3CA KRT14
14 gastrointestinal system cancer 9.7 PTEN PIK3CA
15 breast myoepithelial neoplasm 9.7 PIK3CA KRT14
16 breast adenomyoepithelioma 9.7 PIK3CA KRT14
17 suppression of tumorigenicity 12 9.7 PTEN PIK3CA
18 pregnancy adenoma 9.7 PIK3CA KRT14
19 breast adenocarcinoma 9.7 PTEN PIK3CA
20 adenocarcinoma 9.7 PTEN PIK3CA
21 thyroid cancer, nonmedullary, 2 9.7 PTEN PIK3CA
22 small cell cancer of the lung 9.7 PTEN PIK3CA
23 melanoma, cutaneous malignant 1 9.6 PTEN PIK3CA
24 adamantinoma of long bones 9.6 PTEN PIK3CA
25 lung squamous cell carcinoma 9.6 PTEN PIK3CA
26 cholangiocarcinoma 9.5 PTEN PIK3CA
27 glioblastoma multiforme 9.5 PTEN PIK3CA
28 squamous cell carcinoma, head and neck 9.4 PTEN PIK3CA
29 adenoid cystic carcinoma 9.3 PTEN PIK3CA KRT14
30 cervical cancer 9.2 PTEN PIK3CA KRT14
31 large intestine cancer 9.2 PTEN PIK3CA

Graphical network of the top 20 diseases related to Thyroid Hurthle Cell Adenoma:



Diseases related to Thyroid Hurthle Cell Adenoma

Symptoms & Phenotypes for Thyroid Hurthle Cell Adenoma

MGI Mouse Phenotypes related to Thyroid Hurthle Cell Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.33 KRT14 PIK3CA PTEN
2 neoplasm MP:0002006 9.13 KRT14 PIK3CA PTEN
3 vision/eye MP:0005391 8.8 KRT14 PIK3CA PTEN

Drugs & Therapeutics for Thyroid Hurthle Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Thyroid Hurthle Cell Adenoma

Genetic Tests for Thyroid Hurthle Cell Adenoma

Anatomical Context for Thyroid Hurthle Cell Adenoma

MalaCards organs/tissues related to Thyroid Hurthle Cell Adenoma:

41
Thyroid

Publications for Thyroid Hurthle Cell Adenoma

Articles related to Thyroid Hurthle Cell Adenoma:

# Title Authors PMID Year
1
Cytokeratin 14 expression in epithelial neoplasms: a survey of 435 cases with emphasis on its value in differentiating squamous cell carcinomas from other epithelial tumours. 38
11454039 2001

Variations for Thyroid Hurthle Cell Adenoma

Expression for Thyroid Hurthle Cell Adenoma

Search GEO for disease gene expression data for Thyroid Hurthle Cell Adenoma.

Pathways for Thyroid Hurthle Cell Adenoma

Pathways related to Thyroid Hurthle Cell Adenoma according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12 PTEN PIK3CA
2
Show member pathways
12 PTEN PIK3CA
3
Show member pathways
11.95 PTEN PIK3CA
4
Show member pathways
11.92 PTEN PIK3CA
5
Show member pathways
11.85 PTEN PIK3CA
6
Show member pathways
11.8 PTEN PIK3CA
7
Show member pathways
11.77 PTEN PIK3CA
8 11.76 PTEN PIK3CA
9 11.73 PTEN PIK3CA
10
Show member pathways
11.73 PTEN PIK3CA
11
Show member pathways
11.7 PTEN PIK3CA
12
Show member pathways
11.66 PTEN PIK3CA
13 11.65 PTEN PIK3CA
14 11.57 PTEN PIK3CA
15 11.54 PTEN PIK3CA
16
Show member pathways
11.5 PTEN PIK3CA
17 11.4 PTEN PIK3CA
18 11.37 PTEN PIK3CA
19 11.19 PTEN PIK3CA
20 11.16 PTEN PIK3CA
21 10.99 PTEN PIK3CA
22 10.89 PTEN PIK3CA
23 10.57 PTEN PIK3CA
24 10.1 PTEN PIK3CA

GO Terms for Thyroid Hurthle Cell Adenoma

Biological processes related to Thyroid Hurthle Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.37 PTEN PIK3CA
2 cell migration GO:0016477 9.32 PTEN PIK3CA
3 aging GO:0007568 9.26 PTEN KRT14
4 protein kinase B signaling GO:0043491 9.16 PTEN PIK3CA
5 response to zinc ion GO:0010043 8.96 PTEN KRT14
6 endothelial cell migration GO:0043542 8.62 PTEN PIK3CA

Sources for Thyroid Hurthle Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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