MCID: THY016
MIFTS: 25

Thyroid Hurthle Cell Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Thyroid Hurthle Cell Adenoma

MalaCards integrated aliases for Thyroid Hurthle Cell Adenoma:

Name: Thyroid Hurthle Cell Adenoma 12 15
Benign Oncocytoma of the Thyroid 12
Thyroid Gland Oncocytic Adenoma 73
Hurthle Cell Thyroid Adenoma 29

Classifications:



External Ids:

Disease Ontology 12 DOID:8162
NCIt 50 C6042
UMLS 73 C1336750

Summaries for Thyroid Hurthle Cell Adenoma

MalaCards based summary : Thyroid Hurthle Cell Adenoma, also known as benign oncocytoma of the thyroid, is related to papilloma and ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3. An important gene associated with Thyroid Hurthle Cell Adenoma is KRT14 (Keratin 14), and among its related pathways/superpathways are B cell receptor signaling pathway (KEGG) and TCR signaling (REACTOME). Affiliated tissues include thyroid, and related phenotypes are adipose tissue and neoplasm

Related Diseases for Thyroid Hurthle Cell Adenoma

Diseases related to Thyroid Hurthle Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 papilloma 9.9 KRT14 PTEN
2 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 9.8 PIK3CA PTEN
3 proteus syndrome 9.8 PIK3CA PTEN
4 lipomatosis 9.8 PIK3CA PTEN
5 ovarian clear cell carcinoma 9.8 PIK3CA PTEN
6 bladder squamous cell carcinoma 9.8 PIK3CA PTEN
7 anaplastic thyroid cancer 9.8 PIK3CA PTEN
8 megalencephaly 9.8 PIK3CA PTEN
9 suppression of tumorigenicity 12 9.8 PIK3CA PTEN
10 female reproductive organ cancer 9.8 PIK3CA PTEN
11 renal cell carcinoma, papillary, 1 9.7 PIK3CA PTEN
12 oral cavity cancer 9.7 PIK3CA PTEN
13 respiratory system cancer 9.7 PIK3CA PTEN
14 cowden disease 9.7 PIK3CA PTEN
15 uterine carcinosarcoma 9.7 PIK3CA PTEN
16 breast squamous cell carcinoma 9.7 KRT14 PIK3CA
17 breast adenomyoepithelioma 9.7 KRT14 PIK3CA
18 gastrointestinal system cancer 9.7 PIK3CA PTEN
19 breast myoepithelial neoplasm 9.7 KRT14 PIK3CA
20 pilocytic astrocytoma 9.7 PIK3CA PTEN
21 thyroid cancer, nonmedullary, 2 9.7 PIK3CA PTEN
22 basal cell carcinoma 9.7 KRT14 PTEN
23 skin melanoma 9.6 PIK3CA PTEN
24 small cell cancer of the lung 9.6 PIK3CA PTEN
25 adamantinoma of long bones 9.6 PIK3CA PTEN
26 lung squamous cell carcinoma 9.6 PIK3CA PTEN
27 glioblastoma multiforme 9.5 PIK3CA PTEN
28 brain cancer 9.5 PIK3CA PTEN
29 squamous cell carcinoma, head and neck 9.3 PIK3CA PTEN
30 adenocarcinoma 9.2 PIK3CA PTEN
31 adenoid cystic carcinoma 9.1 KRT14 PIK3CA PTEN
32 gastric adenocarcinoma 9.0 PIK3CA PTEN

Graphical network of the top 20 diseases related to Thyroid Hurthle Cell Adenoma:



Diseases related to Thyroid Hurthle Cell Adenoma

Symptoms & Phenotypes for Thyroid Hurthle Cell Adenoma

MGI Mouse Phenotypes related to Thyroid Hurthle Cell Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.33 KRT14 PIK3CA PTEN
2 neoplasm MP:0002006 9.13 KRT14 PIK3CA PTEN
3 vision/eye MP:0005391 8.8 KRT14 PIK3CA PTEN

Drugs & Therapeutics for Thyroid Hurthle Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Thyroid Hurthle Cell Adenoma

Genetic Tests for Thyroid Hurthle Cell Adenoma

Genetic tests related to Thyroid Hurthle Cell Adenoma:

# Genetic test Affiliating Genes
1 Hurthle Cell Thyroid Adenoma 29

Anatomical Context for Thyroid Hurthle Cell Adenoma

MalaCards organs/tissues related to Thyroid Hurthle Cell Adenoma:

41
Thyroid

Publications for Thyroid Hurthle Cell Adenoma

Variations for Thyroid Hurthle Cell Adenoma

Expression for Thyroid Hurthle Cell Adenoma

Search GEO for disease gene expression data for Thyroid Hurthle Cell Adenoma.

Pathways for Thyroid Hurthle Cell Adenoma

Pathways related to Thyroid Hurthle Cell Adenoma according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.98 PIK3CA PTEN
2
Show member pathways
11.95 PIK3CA PTEN
3
Show member pathways
11.92 PIK3CA PTEN
4
Show member pathways
11.85 PIK3CA PTEN
5
Show member pathways
11.78 PIK3CA PTEN
6 11.77 PIK3CA PTEN
7 11.75 PIK3CA PTEN
8
Show member pathways
11.74 PIK3CA PTEN
9
Show member pathways
11.71 PIK3CA PTEN
10
Show member pathways
11.68 PIK3CA PTEN
11 11.63 PIK3CA PTEN
12
Show member pathways
11.61 PIK3CA PTEN
13 11.57 PIK3CA PTEN
14 11.54 PIK3CA PTEN
15
Show member pathways
11.49 PIK3CA PTEN
16 11.4 PIK3CA PTEN
17 11.37 PIK3CA PTEN
18 11.19 PIK3CA PTEN
19 11.13 PIK3CA PTEN
20 10.99 PIK3CA PTEN
21 10.89 PIK3CA PTEN
22 10.57 PIK3CA PTEN
23 10.1 PIK3CA PTEN

GO Terms for Thyroid Hurthle Cell Adenoma

Biological processes related to Thyroid Hurthle Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.37 PIK3CA PTEN
2 cell migration GO:0016477 9.32 PIK3CA PTEN
3 aging GO:0007568 9.26 KRT14 PTEN
4 phosphatidylinositol biosynthetic process GO:0006661 9.16 PIK3CA PTEN
5 protein kinase B signaling GO:0043491 8.96 PIK3CA PTEN
6 endothelial cell migration GO:0043542 8.62 PIK3CA PTEN

Sources for Thyroid Hurthle Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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