MCID: THY016
MIFTS: 23

Thyroid Hurthle Cell Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Thyroid Hurthle Cell Adenoma

MalaCards integrated aliases for Thyroid Hurthle Cell Adenoma:

Name: Thyroid Hurthle Cell Adenoma 12 15
Benign Oncocytoma of the Thyroid 12
Thyroid Gland Oncocytic Adenoma 71

Classifications:



External Ids:

Disease Ontology 12 DOID:8162
NCIt 49 C6042
UMLS 71 C1336750

Summaries for Thyroid Hurthle Cell Adenoma

MalaCards based summary : Thyroid Hurthle Cell Adenoma, also known as benign oncocytoma of the thyroid, is related to skin papilloma and papilloma. An important gene associated with Thyroid Hurthle Cell Adenoma is KRT14 (Keratin 14), and among its related pathways/superpathways are TCR signaling (REACTOME) and Human T-cell leukemia virus 1 infection. Affiliated tissues include thyroid, breast and ovary, and related phenotypes are adipose tissue and neoplasm

Related Diseases for Thyroid Hurthle Cell Adenoma

Diseases related to Thyroid Hurthle Cell Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 skin papilloma 10.0 PTEN KRT14
2 papilloma 10.0 PTEN KRT14
3 skin squamous cell carcinoma 9.9 PTEN KRT14
4 in situ carcinoma 9.9 PTEN KRT14
5 breast carcinoma in situ 9.9 PTEN KRT14
6 ovarian clear cell adenofibroma 9.8 PTEN PIK3CA
7 thyroid gland anaplastic carcinoma 9.8 PTEN PIK3CA
8 endometrioid ovary carcinoma 9.8 PTEN PIK3CA
9 uterine corpus serous adenocarcinoma 9.8 PTEN PIK3CA
10 hypertrophy of breast 9.8 PTEN PIK3CA
11 breast ductal carcinoma 9.8 PTEN KRT14
12 female reproductive endometrioid cancer 9.8 PTEN PIK3CA
13 uterine body mixed cancer 9.8 PTEN PIK3CA
14 lipomatosis 9.8 PTEN PIK3CA
15 uterine corpus endometrial carcinoma 9.8 PTEN PIK3CA
16 mixed cell type cancer 9.8 PTEN PIK3CA
17 bilateral breast cancer 9.8 PTEN PIK3CA
18 proteus syndrome 9.8 PTEN PIK3CA
19 uterine corpus cancer 9.8 PTEN PIK3CA
20 thyroid tumor 9.8 PTEN PIK3CA
21 vulva cancer 9.8 PTEN PIK3CA
22 ovarian cystadenocarcinoma 9.8 PTEN PIK3CA
23 nevus, epidermal 9.8 PTEN PIK3CA
24 ovarian clear cell carcinoma 9.8 PTEN PIK3CA
25 brain stem glioma 9.8 PTEN PIK3CA
26 adenosquamous carcinoma 9.8 PTEN PIK3CA
27 serous cystadenocarcinoma 9.8 PTEN PIK3CA
28 ovary adenocarcinoma 9.8 PTEN PIK3CA
29 intestinal benign neoplasm 9.8 PTEN PIK3CA
30 carcinosarcoma 9.8 PTEN PIK3CA
31 penile cancer 9.7 PTEN PIK3CA
32 eccrine papillary adenoma 9.7 PIK3CA KRT14
33 thyroid carcinoma 9.7 PTEN PIK3CA
34 rare cancer of corpus uteri 9.7 PTEN PIK3CA
35 cowden syndrome 1 9.7 PTEN PIK3CA
36 cowden syndrome 9.7 PTEN PIK3CA
37 malignant ovarian surface epithelial-stromal neoplasm 9.7 PTEN PIK3CA
38 small cell cancer of the lung 9.7 PTEN PIK3CA
39 ovary epithelial cancer 9.7 PTEN PIK3CA
40 cell type benign neoplasm 9.7 PTEN PIK3CA
41 liposarcoma 9.7 PTEN PIK3CA
42 obsolete: squamous cell carcinoma of head and neck 9.7 PTEN PIK3CA
43 ovarian serous cystadenocarcinoma 9.7 PTEN PIK3CA
44 uterine carcinosarcoma 9.7 PTEN PIK3CA
45 renal cell carcinoma, papillary, 1 9.7 PTEN PIK3CA
46 melanoma, cutaneous malignant 1 9.6 PTEN PIK3CA
47 tuberous sclerosis 9.6 PTEN PIK3CA
48 glioma susceptibility 1 9.6 PTEN PIK3CA
49 oral cavity cancer 9.6 PTEN PIK3CA
50 cholangiocarcinoma 9.6 PTEN PIK3CA

Graphical network of the top 20 diseases related to Thyroid Hurthle Cell Adenoma:



Diseases related to Thyroid Hurthle Cell Adenoma

Symptoms & Phenotypes for Thyroid Hurthle Cell Adenoma

MGI Mouse Phenotypes related to Thyroid Hurthle Cell Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 adipose tissue MP:0005375 9.13 KRT14 PIK3CA PTEN
2 neoplasm MP:0002006 8.8 KRT14 PIK3CA PTEN

Drugs & Therapeutics for Thyroid Hurthle Cell Adenoma

Search Clinical Trials , NIH Clinical Center for Thyroid Hurthle Cell Adenoma

Genetic Tests for Thyroid Hurthle Cell Adenoma

Anatomical Context for Thyroid Hurthle Cell Adenoma

MalaCards organs/tissues related to Thyroid Hurthle Cell Adenoma:

40
Thyroid, Breast, Ovary, Skin, Brain, Lung

Publications for Thyroid Hurthle Cell Adenoma

Articles related to Thyroid Hurthle Cell Adenoma:

# Title Authors PMID Year
1
Cytokeratin 14 expression in epithelial neoplasms: a survey of 435 cases with emphasis on its value in differentiating squamous cell carcinomas from other epithelial tumours. 61
11454039 2001

Variations for Thyroid Hurthle Cell Adenoma

Expression for Thyroid Hurthle Cell Adenoma

Search GEO for disease gene expression data for Thyroid Hurthle Cell Adenoma.

Pathways for Thyroid Hurthle Cell Adenoma

Pathways related to Thyroid Hurthle Cell Adenoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.95 PTEN PIK3CA
2 11.93 PTEN PIK3CA
3
Show member pathways
11.91 PTEN PIK3CA
4
Show member pathways
11.84 PTEN PIK3CA
5
Show member pathways
11.77 PTEN PIK3CA
6 11.76 PTEN PIK3CA
7
Show member pathways
11.73 PTEN PIK3CA
8
Show member pathways
11.7 PTEN PIK3CA
9
Show member pathways
11.66 PTEN PIK3CA
10 11.65 PTEN PIK3CA
11 11.57 PTEN PIK3CA
12 11.54 PTEN PIK3CA
13
Show member pathways
11.5 PTEN PIK3CA
14 11.4 PTEN PIK3CA
15 11.37 PTEN PIK3CA
16 11.21 PTEN PIK3CA
17 11.14 PTEN PIK3CA
18 10.99 PTEN PIK3CA
19 10.89 PTEN PIK3CA
20 10.57 PTEN PIK3CA
21 10.1 PTEN PIK3CA

GO Terms for Thyroid Hurthle Cell Adenoma

Biological processes related to Thyroid Hurthle Cell Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 aging GO:0007568 9.32 PTEN KRT14
2 phosphatidylinositol biosynthetic process GO:0006661 9.26 PTEN PIK3CA
3 protein kinase B signaling GO:0043491 9.16 PTEN PIK3CA
4 endothelial cell migration GO:0043542 8.96 PTEN PIK3CA
5 response to zinc ion GO:0010043 8.62 PTEN KRT14

Sources for Thyroid Hurthle Cell Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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