MCID: THY009
MIFTS: 43

Thyroid Lymphoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases, Rare diseases

Aliases & Classifications for Thyroid Lymphoma

Summaries for Thyroid Lymphoma

MalaCards based summary : Thyroid Lymphoma is related to adult t-cell leukemia and hashimoto thyroiditis. An important gene associated with Thyroid Lymphoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Regulation of TP53 Activity and Human cytomegalovirus infection. Affiliated tissues include thyroid, b cells and t cells, and related phenotypes are goiter and lymphoma

Wikipedia : 77 Thyroid lymphoma is a rare malignant tumor constituting 1% to 2% of all thyroid malignancies and less... more...

Related Diseases for Thyroid Lymphoma

Diseases related to Thyroid Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 adult t-cell leukemia 29.5 FAS TP53
2 hashimoto thyroiditis 11.5
3 lymphoma 10.8
4 thyroiditis 10.4
5 suppressor of tumorigenicity 3 10.2 CCNB1 TP53
6 chronic venous leg ulcers 10.2 FAS TP53
7 acute erythroid leukemia 10.2 PICALM TP53
8 thyroid cancer 10.1
9 splenic diffuse red pulp small b-cell lymphoma 10.1 CCNA2 TP53
10 leukemia, acute lymphoblastic 3 10.1 IL7 TP53
11 soft tissue sarcoma 10.0 TNF TP53
12 chronic salpingitis 10.0 TNF TP53
13 tonsil cancer 10.0 TNF TP53
14 cheilitis 10.0 TNF TP53
15 lymphopenia 10.0 FAS IL7
16 goiter 9.9
17 atrophic gastritis 9.9 TNF TP53
18 human immunodeficiency virus infectious disease 9.9 IL7 TNF
19 hematologic cancer 9.9 IL7 PICALM TP53
20 pancreas disease 9.9 TNF TP53
21 upper respiratory tract disease 9.9 TNF TP53
22 kashin-beck disease 9.9 FAS TNF
23 leukemia, chronic lymphocytic 9.9 FAS IL7 TP53
24 thyroid cancer, nonmedullary, 1 9.9
25 thyroid gland anaplastic carcinoma 9.9
26 hypersensitivity reaction type iv disease 9.9 FAS TNF
27 epstein-barr virus-associated gastric carcinoma 9.9 FAS TNF
28 leukocyte disease 9.9 TNF TP53
29 silicosis 9.9 FAS TNF
30 severe cutaneous adverse reaction 9.8 FAS TNF
31 pneumoconiosis 9.8 FAS TNF
32 subacute thyroiditis 9.8
33 hyperthyroidism 9.8
34 cytomegalovirus infection 9.7 FAS TNF
35 large intestine cancer 9.7 CCNB1 TNF TP53
36 squamous cell carcinoma 9.7 CCNA2 FAS TP53
37 female reproductive system disease 9.7 TNF TP53
38 breast adenocarcinoma 9.7 FAS TNF TP53
39 aplastic anemia 9.7 FAS TNF TP53
40 graft-versus-host disease 9.7 FAS TNF
41 gastric adenocarcinoma 9.7 FAS TNF TP53
42 nuchal bleb, familial 9.6
43 stroke, ischemic 9.6
44 diffuse large b-cell lymphoma 9.6
45 leukemia 9.6
46 ulcerative colitis 9.6
47 multinodular goiter 9.6
48 colitis 9.6
49 dermatomyositis 9.6
50 graves' disease 9.6

Graphical network of the top 20 diseases related to Thyroid Lymphoma:



Diseases related to Thyroid Lymphoma

Symptoms & Phenotypes for Thyroid Lymphoma

Human phenotypes related to Thyroid Lymphoma:

60 33 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 goiter 60 33 obligate (100%) Obligate (100%) HP:0000853
2 lymphoma 60 33 obligate (100%) Obligate (100%) HP:0002665
3 broad neck 60 33 hallmark (90%) Very frequent (99-80%) HP:0000475
4 hypothyroidism 60 33 frequent (33%) Frequent (79-30%) HP:0000821
5 dysphagia 60 33 frequent (33%) Frequent (79-30%) HP:0002015
6 hashimoto thyroiditis 60 33 frequent (33%) Frequent (79-30%) HP:0000872
7 hoarse voice 60 33 frequent (33%) Frequent (79-30%) HP:0001609
8 lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0002716
9 upper airway obstruction 60 33 frequent (33%) Frequent (79-30%) HP:0002781
10 stridor 60 33 frequent (33%) Frequent (79-30%) HP:0010307
11 hyperthyroidism 60 33 occasional (7.5%) Occasional (29-5%) HP:0000836
12 pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0012531
13 respiratory distress 60 33 very rare (1%) Very rare (<4-1%) HP:0002098
14 dyspnea 60 Frequent (79-30%)

MGI Mouse Phenotypes related to Thyroid Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CCNA2 FAS IL7 PICALM TNF TP53
2 immune system MP:0005387 9.1 CCNA2 FAS IL7 PICALM TNF TP53

Drugs & Therapeutics for Thyroid Lymphoma

Search Clinical Trials , NIH Clinical Center for Thyroid Lymphoma

Genetic Tests for Thyroid Lymphoma

Anatomical Context for Thyroid Lymphoma

MalaCards organs/tissues related to Thyroid Lymphoma:

42
Thyroid, B Cells, T Cells, Colon, Pancreas, Myeloid, Tonsil

Publications for Thyroid Lymphoma

Articles related to Thyroid Lymphoma:

(show top 50) (show all 196)
# Title Authors Year
1
Primary Thyroid Lymphoma: An Analysis of the National Cancer Database. ( 31057992 )
2019
2
Spontaneous Regression of Primary Thyroid Lymphoma: Two Rarities at the Same Time. ( 30632122 )
2019
3
Primary Thyroid Lymphoma: External Beam Radiation Therapy Induced Thyroiditis Mimics Residual Disease on Serial 18F-FDG PET/CT Imaging. ( 29393054 )
2018
4
Cytodiagnosis of Primary Thyroid Lymphoma Coincident with Unnoticed Papillary Thyroid Carcinoma: A Case Report and Review of the Literature. ( 30089952 )
2018
5
Primary Diffuse B-Cell Thyroid Lymphoma: Case Report and Literature Review. ( 30140214 )
2018
6
Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study. ( 30349374 )
2018
7
When a Goitre is a Thyroid Lymphoma. ( 30756001 )
2018
8
Ultrasonography in the Diagnosis and Monitoring of Therapy for Primary Thyroid Lymphoma. ( 30601440 )
2018
9
Fine-needle aspiration to diagnose primary thyroid lymphoma: a systematic review and meta-analysis. ( 30566902 )
2018
10
Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma. ( 29268549 )
2017
11
Eleven patients with primary thyroid lymphoma: a single center experience ( 29151299 )
2017
12
Errata:Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry [Endocrine Journal Vol. 64 (9): 859-865, 2017]. ( 29081471 )
2017
13
A Review of Primary Thyroid Lymphoma: Molecular Factors, Diagnosis and Management. ( 29058491 )
2017
14
Diagnosis and Clinical Analysis of Primary Thyroid Lymphoma. ( 28695809 )
2017
15
Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry. ( 28690277 )
2017
16
Primary thyroid lymphoma: a rare but challenging diagnosis. ( 28581452 )
2017
17
Primary thyroid lymphoma: A case report and review of the literature. ( 28053701 )
2017
18
Multi-institutional study of fine-needle aspiration for thyroid lymphoma. ( 31042520 )
2016
19
Primary Thyroid Lymphoma: Clinicopathologic Characteristics and Therapeutic Outcomes of Six Cases in Morocco. ( 28191800 )
2016
20
Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report. ( 28031089 )
2016
21
Residual FDG uptake of primary thyroid lymphoma after treatment may overestimate residual lymphoma. ( 27614754 )
2016
22
Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Primary Thyroid Lymphoma for Elderly Adults. ( 27557116 )
2016
23
Clinical Presentation and Diagnostic Challenges of Thyroid Lymphoma: A Cohort Study. ( 27256107 )
2016
24
Development of Primary Thyroid Lymphoma during an Ultrasonographic Follow-up of Hashimoto's Thyroiditis: A Report of 9 Cases. ( 27086809 )
2016
25
Primary thyroid lymphoma. ( 26985163 )
2016
26
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. ( 26608372 )
2016
27
Hoarseness: an unusual presentation of primary thyroid lymphoma with laryngeal infiltration. ( 26411267 )
2016
28
Core needle biopsy could reduce diagnostic surgery in patients with anaplastic thyroid cancer or thyroid lymphoma. ( 26201291 )
2016
29
Primary thyroid lymphoma presenting as dermatomyositis: a first case and review of the literature. ( 27126096 )
2016
30
Evaluation of primary thyroid lymphoma by ultrasonography combined with contrast-enhanced ultrasonography: A pilot study. ( 26960472 )
2015
31
Complete resolution of autoimmune thyroiditis after R-CHOP in a patient with thyroid lymphoma. ( 26687264 )
2015
32
Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study. ( 26665123 )
2015
33
Primary thyroid lymphoma: The two ends of the spectrum. ( 26416071 )
2015
34
12 cases of primary thyroid lymphoma in China. ( 25736543 )
2015
35
Primary thyroid lymphoma: multi-slice computed tomography findings. ( 25735344 )
2015
36
Primary thyroid lymphoma has different sonographic and color Doppler features compared to nodular goiter. ( 25614405 )
2015
37
Primary thyroid lymphoma: A rare disease. ( 25745292 )
2014
38
Sonographic appearance of primary thyroid lymphoma-preliminary experience. ( 25474402 )
2014
39
Identification of primary thyroid lymphoma with medical imaging: A case report and review of the literature. ( 25364417 )
2014
40
Primary thyroid lymphoma: case series with review of literature. ( 25332615 )
2014
41
Aggressive primary thyroid lymphoma: imaging features of two elderly patients. ( 25060184 )
2014
42
Primary thyroid lymphoma. ( 24935697 )
2014
43
Non-Hodgkin's thyroid lymphoma associated with Hashimoto's thyroiditis. ( 24864614 )
2014
44
Diagnosing thyroid lymphoma: steroid administration may result in rapid improvement of dyspnea : a report of two cases. ( 24696693 )
2014
45
Thyroid lymphoma on a background of Hashimoto's thyroiditis: PET/CT appearances. ( 24679651 )
2014
46
Rituximab-including combined modality treatment for primary thyroid lymphoma: an effective regimen for elderly patients. ( 24547778 )
2014
47
Hypothyroidism after radiotherapy for primary thyroid lymphoma. ( 25075081 )
2014
48
Fine needle cytology and flow cytometry in hashimoto thyroiditis and primary thyroid lymphoma. ( 24642841 )
2014
49
A Rare but Significant Cause of an Enlarging Neck Mass: A Case Report of Primary Thyroid Lymphoma. ( 29147348 )
2013
50
A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma. ( 24005594 )
2013

Variations for Thyroid Lymphoma

Expression for Thyroid Lymphoma

Search GEO for disease gene expression data for Thyroid Lymphoma.

Pathways for Thyroid Lymphoma

Pathways related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 CCNA2 CCNB1 FAS TP53
2
Show member pathways
12.56 CCNA2 CCNB1 FAS TNF TP53
3
Show member pathways
12.49 CCNA2 FAS IL7 TNF TP53
4
Show member pathways
12.43 FAS TNF TP53
5
Show member pathways
12.39 CCNA2 CCNB1 TP53
6
Show member pathways
12.37 CCNA2 CCNB1 FAS TP53
7
Show member pathways
12.32 CCNA2 CCNB1 TP53
8 12.26 CCNA2 CCNB1 TP53
9
Show member pathways
12.11 CCNB1 FAS TP53
10 12.09 CCNA2 CCNB1 TP53
11
Show member pathways
12.07 CCNA2 CCNB1 TP53
12
Show member pathways
12.04 CCNA2 CCNB1 FAS TP53
13 12.02 FAS TNF TP53
14 11.87 CCNA2 CCNB1 TP53
15 11.77 CCNB1 FAS TP53
16
Show member pathways
11.74 CCNA2 CCNB1 TP53
17
Show member pathways
11.62 CCNA2 CCNB1 TP53
18 11.53 FAS TP53
19
Show member pathways
11.52 CCNA2 TP53
20 11.52 CCNA2 CCNB1 TP53
21 11.42 CCNA2 TP53
22 11.37 CCNA2 CCNB1
23
Show member pathways
11.37 FAS TP53
24
Show member pathways
11.28 CCNB1 TP53
25 11.26 CCNA2 TP53
26 11.17 FAS TNF
27
Show member pathways
11.14 CCNA2 CCNB1
28 11.11 CCNA2 CCNB1
29 11.09 IL7 TNF
30 11.04 IL7 TNF
31 10.98 FAS TNF TP53
32 10.79 CCNB1 TP53
33 10.64 CCNA2 CCNB1 TP53
34 10.63 CCNA2 FAS TNF TP53

GO Terms for Thyroid Lymphoma

Cellular components related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCNA2 CCNB1

Biological processes related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.7 FAS TNF TP53
2 cytokine-mediated signaling pathway GO:0019221 9.63 IL7 TNF TP53
3 positive regulation of transcription, DNA-templated GO:0045893 9.62 CCNA2 PICALM TNF TP53
4 Ras protein signal transduction GO:0007265 9.58 CCNA2 TP53
5 apoptotic signaling pathway GO:0097190 9.58 FAS TNF
6 negative regulation of gene expression GO:0010629 9.58 CCNB1 PICALM TNF
7 humoral immune response GO:0006959 9.57 IL7 TNF
8 positive regulation of cell cycle GO:0045787 9.56 CCNA2 CCNB1
9 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.55 CCNB1 TP53
10 positive regulation of fibroblast proliferation GO:0048146 9.54 CCNA2 CCNB1
11 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.51 CCNA2 CCNB1
12 extrinsic apoptotic signaling pathway GO:0097191 9.49 FAS TNF
13 regulation of mitotic nuclear division GO:0007088 9.48 CCNA2 CCNB1
14 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.43 IL7 TNF
15 cellular response to hypoxia GO:0071456 9.43 CCNA2 CCNB1 TP53
16 positive regulation of chemokine production GO:0032722 9.37 IL7 TNF
17 necroptotic signaling pathway GO:0097527 9.16 FAS TNF
18 cellular response to organic cyclic compound GO:0071407 9.13 CCNA2 CCNB1 TNF
19 protein-containing complex assembly GO:0065003 8.92 CCNB1 FAS PICALM TP53

Molecular functions related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 8.62 CCNA2 CCNB1

Sources for Thyroid Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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