MCID: THY009
MIFTS: 43

Thyroid Lymphoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases, Rare diseases

Aliases & Classifications for Thyroid Lymphoma

Summaries for Thyroid Lymphoma

MalaCards based summary : Thyroid Lymphoma is related to adult t-cell leukemia and hashimoto thyroiditis. An important gene associated with Thyroid Lymphoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Human cytomegalovirus infection. Affiliated tissues include thyroid, b cells and colon, and related phenotypes are goiter and lymphoma

Wikipedia : 77 Thyroid lymphoma is a rare malignant tumor constituting 1% to 2% of all thyroid malignancies and less... more...

Related Diseases for Thyroid Lymphoma

Graphical network of the top 20 diseases related to Thyroid Lymphoma:



Diseases related to Thyroid Lymphoma

Symptoms & Phenotypes for Thyroid Lymphoma

Human phenotypes related to Thyroid Lymphoma:

60 33 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 goiter 60 33 obligate (100%) Obligate (100%) HP:0000853
2 lymphoma 60 33 obligate (100%) Obligate (100%) HP:0002665
3 broad neck 60 33 hallmark (90%) Very frequent (99-80%) HP:0000475
4 hypothyroidism 60 33 frequent (33%) Frequent (79-30%) HP:0000821
5 dysphagia 60 33 frequent (33%) Frequent (79-30%) HP:0002015
6 hashimoto thyroiditis 60 33 frequent (33%) Frequent (79-30%) HP:0000872
7 hoarse voice 60 33 frequent (33%) Frequent (79-30%) HP:0001609
8 lymphadenopathy 60 33 frequent (33%) Frequent (79-30%) HP:0002716
9 upper airway obstruction 60 33 frequent (33%) Frequent (79-30%) HP:0002781
10 stridor 60 33 frequent (33%) Frequent (79-30%) HP:0010307
11 hyperthyroidism 60 33 occasional (7.5%) Occasional (29-5%) HP:0000836
12 pain 60 33 occasional (7.5%) Occasional (29-5%) HP:0012531
13 respiratory distress 60 33 very rare (1%) Very rare (<4-1%) HP:0002098
14 dyspnea 60 Frequent (79-30%)

MGI Mouse Phenotypes related to Thyroid Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 CCNA2 FAS IL7 PICALM TP53 TP73
2 immune system MP:0005387 9.1 CCNA2 FAS IL7 PICALM TP53 TP73

Drugs & Therapeutics for Thyroid Lymphoma

Search Clinical Trials , NIH Clinical Center for Thyroid Lymphoma

Genetic Tests for Thyroid Lymphoma

Anatomical Context for Thyroid Lymphoma

MalaCards organs/tissues related to Thyroid Lymphoma:

42
Thyroid, B Cells, Colon, T Cells

Publications for Thyroid Lymphoma

Articles related to Thyroid Lymphoma:

(show top 50) (show all 195)
# Title Authors Year
1
Spontaneous Regression of Primary Thyroid Lymphoma: Two Rarities at the Same Time. ( 30632122 )
2019
2
Primary Thyroid Lymphoma: External Beam Radiation Therapy Induced Thyroiditis Mimics Residual Disease on Serial<sup>18</sup>F-FDG PET/CT Imaging. ( 29393054 )
2018
3
When a Goitre is a Thyroid Lymphoma. ( 30756001 )
2018
4
Ultrasonography in the Diagnosis and Monitoring of Therapy for Primary Thyroid Lymphoma. ( 30601440 )
2018
5
Fine-needle aspiration to diagnose primary thyroid lymphoma: a systematic review and meta-analysis. ( 30566902 )
2018
6
Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study. ( 30349374 )
2018
7
Primary Diffuse B-Cell Thyroid Lymphoma: Case Report and Literature Review. ( 30140214 )
2018
8
Cytodiagnosis of Primary Thyroid Lymphoma Coincident with Unnoticed Papillary Thyroid Carcinoma: A Case Report and Review of the Literature. ( 30089952 )
2018
9
Primary thyroid lymphoma: a rare but challenging diagnosis. ( 28581452 )
2017
10
A Review of Primary Thyroid Lymphoma: Molecular Factors, Diagnosis and Management. ( 29058491 )
2017
11
Errata:Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry [Endocrine Journal Vol. 64 (9): 859-865, 2017]. ( 29081471 )
2017
12
Eleven patients with primary thyroid lymphoma: a single center experience ( 29151299 )
2017
13
Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma. ( 29268549 )
2017
14
Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry. ( 28690277 )
2017
15
Primary thyroid lymphoma: A case report and review of the literature. ( 28053701 )
2017
16
Diagnosis and Clinical Analysis of Primary Thyroid Lymphoma. ( 28695809 )
2017
17
Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Primary Thyroid Lymphoma for Elderly Adults. ( 27557116 )
2016
18
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. ( 26614433 )
2016
19
Primary thyroid lymphoma. ( 26985163 )
2016
20
Residual FDG uptake of primary thyroid lymphoma after treatment may overestimate residual lymphoma. ( 27614754 )
2016
21
Primary Thyroid Lymphoma: Clinicopathologic Characteristics and Therapeutic Outcomes of Six Cases in Morocco. ( 28191800 )
2016
22
Primary thyroid lymphoma presenting as dermatomyositis: a first case and review of the literature. ( 27126096 )
2016
23
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. ( 26608372 )
2016
24
Development of Primary Thyroid Lymphoma during an Ultrasonographic Follow-up of Hashimoto's Thyroiditis: A Report of 9 Cases. ( 27086809 )
2016
25
Clinical Presentation and Diagnostic Challenges of Thyroid Lymphoma: A Cohort Study. ( 27256107 )
2016
26
Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report. ( 28031089 )
2016
27
Primary thyroid lymphoma: The two ends of the spectrum. ( 26416071 )
2015
28
Complete resolution of autoimmune thyroiditis after R-CHOP in a patient with thyroid lymphoma. ( 26687264 )
2015
29
Evaluation of primary thyroid lymphoma by ultrasonography combined with contrast-enhanced ultrasonography: A pilot study. ( 26960472 )
2015
30
Primary thyroid lymphoma: multi-slice computed tomography findings. ( 25735344 )
2015
31
Hoarseness: an unusual presentation of primary thyroid lymphoma with laryngeal infiltration. ( 26411267 )
2015
32
Core needle biopsy could reduce diagnostic surgery in patients with anaplastic thyroid cancer or thyroid lymphoma. ( 26201291 )
2015
33
Primary thyroid lymphoma has different sonographic and color Doppler features compared to nodular goiter. ( 25614405 )
2015
34
Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study. ( 26665123 )
2015
35
12 cases of primary thyroid lymphoma in China. ( 25736543 )
2015
36
Thyroid lymphoma on a background of Hashimoto's thyroiditis: PET/CT appearances. ( 24679651 )
2014
37
Hypothyroidism after radiotherapy for primary thyroid lymphoma. ( 25075081 )
2014
38
Non-Hodgkin's thyroid lymphoma associated with Hashimoto's thyroiditis. ( 24864614 )
2014
39
Sonographic appearance of primary thyroid lymphoma-preliminary experience. ( 25474402 )
2014
40
Primary thyroid lymphoma: case series with review of literature. ( 25332615 )
2014
41
Aggressive primary thyroid lymphoma: imaging features of two elderly patients. ( 25060184 )
2014
42
Primary thyroid lymphoma: A rare disease. ( 25745292 )
2014
43
Diagnosing thyroid lymphoma: steroid administration may result in rapid improvement of dyspnea : a report of two cases. ( 24696693 )
2014
44
Primary thyroid lymphoma. ( 24935697 )
2014
45
Fine needle cytology and flow cytometry in hashimoto thyroiditis and primary thyroid lymphoma. ( 24642841 )
2014
46
Identification of primary thyroid lymphoma with medical imaging: A case report and review of the literature. ( 25364417 )
2014
47
Rituximab-including combined modality treatment for primary thyroid lymphoma: an effective regimen for elderly patients. ( 24547778 )
2014
48
Primary thyroid lymphoma: a series of two cases and review of literature. ( 24772759 )
2013
49
Patterns of care and treatment outcomes for primary thyroid lymphoma: a single institution study. ( 24501704 )
2013
50
Thyroid lymphoma incidentally detected by 18F-fluorocholine (FCH) PET/CT. ( 23856826 )
2013

Variations for Thyroid Lymphoma

Expression for Thyroid Lymphoma

Search GEO for disease gene expression data for Thyroid Lymphoma.

Pathways for Thyroid Lymphoma

Pathways related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.69 CCNA2 FAS IL7 TP53
2
Show member pathways
12.68 CCNA2 CCNB1 FAS TP53
3
Show member pathways
12.46 FAS TP53 TP73
4
Show member pathways
12.42 CCNA2 CCNB1 FAS TP53
5
Show member pathways
12.39 CCNA2 CCNB1 TP53
6
Show member pathways
12.37 CCNA2 CCNB1 FAS TP53 TP73
7
Show member pathways
12.32 CCNA2 CCNB1 TP53
8 12.18 CCNA2 CCNB1 TP53 TP73
9 12.11 CCNA2 CCNB1 TP53
10
Show member pathways
12.09 CCNA2 CCNB1 TP53
11
Show member pathways
12.08 CCNA2 CCNB1 FAS TP53
12
Show member pathways
11.93 CCNB1 FAS TP53 TP73
13 11.9 CCNA2 CCNB1 TP53
14
Show member pathways
11.73 CCNA2 CCNB1 TP53
15
Show member pathways
11.7 FAS TP53 TP73
16
Show member pathways
11.66 CCNA2 CCNB1 TP53
17 11.58 CCNA2 CCNB1 TP53
18 11.57 CCNB1 TP53
19
Show member pathways
11.55 CCNB1 TP53 TP73
20 11.53 CCNA2 TP73
21 11.52 FAS TP53
22
Show member pathways
11.52 CCNA2 TP53
23 11.42 CCNA2 TP53
24 11.37 CCNA2 CCNB1
25
Show member pathways
11.37 FAS TP53
26
Show member pathways
11.27 CCNB1 TP53
27 11.25 CCNA2 TP53
28 11.25 FAS TP53
29 11.21 CCNA2 FAS TP53
30
Show member pathways
11.14 CCNA2 CCNB1
31 11.11 CCNA2 CCNB1
32 11.04 CCNB1 FAS TP53 TP73
33
Show member pathways
10.89 TP53 TP73
34 10.82 CCNB1 TP53
35 10.64 CCNA2 CCNB1 TP53

GO Terms for Thyroid Lymphoma

Cellular components related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCNA2 CCNB1

Biological processes related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 viral process GO:0016032 9.75 CCNA2 TP53 TP73
2 positive regulation of apoptotic process GO:0043065 9.69 FAS TP53 TP73
3 regulation of apoptotic process GO:0042981 9.61 FAS TP53 TP73
4 regulation of signal transduction by p53 class mediator GO:1901796 9.58 TP53 TP73
5 cellular response to organic cyclic compound GO:0071407 9.57 CCNA2 CCNB1
6 Ras protein signal transduction GO:0007265 9.56 CCNA2 TP53
7 cell cycle GO:0007049 9.56 CCNA2 CCNB1 TP53 TP73
8 positive regulation of cell cycle GO:0045787 9.55 CCNA2 CCNB1
9 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.54 CCNB1 TP53
10 positive regulation of fibroblast proliferation GO:0048146 9.52 CCNA2 CCNB1
11 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.49 CCNA2 CCNB1
12 regulation of mitotic nuclear division GO:0007088 9.48 CCNA2 CCNB1
13 protein tetramerization GO:0051262 9.46 TP53 TP73
14 positive regulation of transcription, DNA-templated GO:0045893 9.46 CCNA2 PICALM TP53 TP73
15 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.4 TP53 TP73
16 positive regulation of cell cycle arrest GO:0071158 9.37 TP53 TP73
17 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.32 TP53 TP73
18 cellular response to hypoxia GO:0071456 9.13 CCNA2 CCNB1 TP53
19 protein-containing complex assembly GO:0065003 8.92 CCNB1 FAS PICALM TP53

Molecular functions related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 p53 binding GO:0002039 9.16 TP53 TP73
2 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 8.96 CCNA2 CCNB1
3 protein kinase binding GO:0019901 8.92 CCNA2 CCNB1 TP53 TP73

Sources for Thyroid Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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