MCID: THY009
MIFTS: 47

Thyroid Lymphoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases, Rare diseases

Aliases & Classifications for Thyroid Lymphoma

Summaries for Thyroid Lymphoma

MalaCards based summary : Thyroid Lymphoma is related to hashimoto thyroiditis and lymphoma. An important gene associated with Thyroid Lymphoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Human cytomegalovirus infection and Regulation of TP53 Activity. Affiliated tissues include thyroid, b cells and colon, and related phenotypes are hypothyroidism and dysphagia

Wikipedia : 76 Thyroid lymphoma is a rare malignant tumor constituting 1% to 2% of all thyroid malignancies and less... more...

Related Diseases for Thyroid Lymphoma

Diseases related to Thyroid Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 hashimoto thyroiditis 11.4
2 lymphoma 10.8
3 thyroiditis 10.3
4 suppressor of tumorigenicity 3 10.1 CCNB1 TP53
5 soft tissue sarcoma 10.1 TNF TP53
6 chronic salpingitis 10.1 TNF TP53
7 acute erythroid leukemia 10.1 PICALM TP53
8 anal squamous cell carcinoma 10.1 TP53 TP73
9 tonsil cancer 10.1 TNF TP53
10 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.1 TP53 TP73
11 cheilitis 10.1 TNF TP53
12 ulcerative stomatitis 10.1 TP53 TP73
13 human immunodeficiency virus infectious disease 10.0 IL7 TNF
14 interleukin-7 receptor alpha deficiency 10.0 IL7 IL7R
15 atrophic gastritis 10.0 TNF TP53
16 severe combined immunodeficiency, x-linked 10.0 IL7 IL7R
17 epstein-barr virus-associated gastric carcinoma 10.0 TNF TP73
18 pancreas disease 10.0 TNF TP53
19 combined t cell and b cell immunodeficiency 10.0 IL7 IL7R
20 splenic diffuse red pulp small b-cell lymphoma 10.0 CCNA2 TP53
21 upper respiratory tract disease 10.0 TNF TP53
22 leukemia, acute lymphoblastic 3 10.0 IL7 TP53
23 anaplastic thyroid cancer 10.0
24 primary progressive multiple sclerosis 10.0 IL7R TNF
25 hematologic cancer 9.9 IL7 PICALM TP53
26 large intestine cancer 9.9 CCNB1 TNF TP53
27 leukocyte disease 9.9 TNF TP53
28 thyroid cancer, nonmedullary, 1 9.9
29 goiter 9.9
30 thyroid cancer 9.9
31 leukemia, acute myeloid 9.9 PICALM TNF TP53
32 multiple sclerosis 9.8 IL7 IL7R TNF
33 subacute thyroiditis 9.8
34 hyperthyroidism 9.8
35 stroke, ischemic 9.6
36 adult t-cell leukemia 9.6
37 b-cell lymphomas 9.6
38 diffuse large b-cell lymphoma 9.6
39 ulcerative colitis 9.6
40 multinodular goiter 9.6
41 colitis 9.6
42 dermatomyositis 9.6
43 graves' disease 9.6
44 nodular goiter 9.6
45 hypothyroidism 9.6
46 t-cell leukemia 9.6
47 dysphagia 9.6
48 differentiated thyroid carcinoma 9.6

Graphical network of the top 20 diseases related to Thyroid Lymphoma:



Diseases related to Thyroid Lymphoma

Symptoms & Phenotypes for Thyroid Lymphoma

Human phenotypes related to Thyroid Lymphoma:

59 32 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0000821
2 dysphagia 59 32 frequent (33%) Frequent (79-30%) HP:0002015
3 respiratory distress 59 32 very rare (1%) Very rare (<4-1%) HP:0002098
4 broad neck 59 32 hallmark (90%) Very frequent (99-80%) HP:0000475
5 hashimoto thyroiditis 59 32 frequent (33%) Frequent (79-30%) HP:0000872
6 hyperthyroidism 59 32 occasional (7.5%) Occasional (29-5%) HP:0000836
7 goiter 59 32 obligate (100%) Obligate (100%) HP:0000853
8 pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0012531
9 lymphoma 59 32 obligate (100%) Obligate (100%) HP:0002665
10 hoarse voice 59 32 frequent (33%) Frequent (79-30%) HP:0001609
11 lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002716
12 upper airway obstruction 59 32 frequent (33%) Frequent (79-30%) HP:0002781
13 stridor 59 32 frequent (33%) Frequent (79-30%) HP:0010307
14 dyspnea 59 Frequent (79-30%)

MGI Mouse Phenotypes related to Thyroid Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 CCNA2 IL7 IL7R PICALM TNF TP53
2 embryo MP:0005380 9.65 CCNA2 PICALM TNF TP53 TP73
3 immune system MP:0005387 9.5 CCNA2 IL7 IL7R PICALM TNF TP53
4 neoplasm MP:0002006 8.92 IL7R TNF TP53 TP73

Drugs & Therapeutics for Thyroid Lymphoma

Search Clinical Trials , NIH Clinical Center for Thyroid Lymphoma

Genetic Tests for Thyroid Lymphoma

Anatomical Context for Thyroid Lymphoma

MalaCards organs/tissues related to Thyroid Lymphoma:

41
Thyroid, B Cells, Colon, T Cells, Tonsil, Pancreas, Cervix

Publications for Thyroid Lymphoma

Articles related to Thyroid Lymphoma:

(show top 50) (show all 191)
# Title Authors Year
1
Primary Thyroid Lymphoma: External Beam Radiation Therapy Induced Thyroiditis Mimics Residual Disease on Serial<sup>18</sup>F-FDG PET/CT Imaging. ( 29393054 )
2018
2
Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study. ( 30349374 )
2018
3
Cytodiagnosis of Primary Thyroid Lymphoma Coincident with Unnoticed Papillary Thyroid Carcinoma: A Case Report and Review of the Literature. ( 30089952 )
2018
4
Primary Diffuse B-Cell Thyroid Lymphoma: Case Report and Literature Review. ( 30140214 )
2018
5
Primary thyroid lymphoma: a rare but challenging diagnosis. ( 28581452 )
2017
6
A Review of Primary Thyroid Lymphoma: Molecular Factors, Diagnosis and Management. ( 29058491 )
2017
7
Errata:Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry [Endocrine Journal Vol. 64 (9): 859-865, 2017]. ( 29081471 )
2017
8
Eleven patients with primary thyroid lymphoma: a single center experience ( 29151299 )
2017
9
Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma. ( 29268549 )
2017
10
Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry. ( 28690277 )
2017
11
Primary thyroid lymphoma: A case report and review of the literature. ( 28053701 )
2017
12
Diagnosis and Clinical Analysis of Primary Thyroid Lymphoma. ( 28695809 )
2017
13
Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Primary Thyroid Lymphoma for Elderly Adults. ( 27557116 )
2016
14
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. ( 26614433 )
2016
15
Primary thyroid lymphoma. ( 26985163 )
2016
16
Residual FDG uptake of primary thyroid lymphoma after treatment may overestimate residual lymphoma. ( 27614754 )
2016
17
Primary Thyroid Lymphoma: Clinicopathologic Characteristics and Therapeutic Outcomes of Six Cases in Morocco. ( 28191800 )
2016
18
Primary thyroid lymphoma presenting as dermatomyositis: a first case and review of the literature. ( 27126096 )
2016
19
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. ( 26608372 )
2016
20
Development of Primary Thyroid Lymphoma during an Ultrasonographic Follow-up of Hashimoto's Thyroiditis: A Report of 9 Cases. ( 27086809 )
2016
21
Clinical Presentation and Diagnostic Challenges of Thyroid Lymphoma: A Cohort Study. ( 27256107 )
2016
22
Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report. ( 28031089 )
2016
23
Primary thyroid lymphoma: The two ends of the spectrum. ( 26416071 )
2015
24
Complete resolution of autoimmune thyroiditis after R-CHOP in a patient with thyroid lymphoma. ( 26687264 )
2015
25
Evaluation of primary thyroid lymphoma by ultrasonography combined with contrast-enhanced ultrasonography: A pilot study. ( 26960472 )
2015
26
Primary thyroid lymphoma: multi-slice computed tomography findings. ( 25735344 )
2015
27
Hoarseness: an unusual presentation of primary thyroid lymphoma with laryngeal infiltration. ( 26411267 )
2015
28
Core needle biopsy could reduce diagnostic surgery in patients with anaplastic thyroid cancer or thyroid lymphoma. ( 26201291 )
2015
29
Primary thyroid lymphoma has different sonographic and color Doppler features compared to nodular goiter. ( 25614405 )
2015
30
Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study. ( 26665123 )
2015
31
12 cases of primary thyroid lymphoma in China. ( 25736543 )
2015
32
Thyroid lymphoma on a background of Hashimoto's thyroiditis: PET/CT appearances. ( 24679651 )
2014
33
Hypothyroidism after radiotherapy for primary thyroid lymphoma. ( 25075081 )
2014
34
Non-Hodgkin's thyroid lymphoma associated with Hashimoto's thyroiditis. ( 24864614 )
2014
35
Sonographic appearance of primary thyroid lymphoma-preliminary experience. ( 25474402 )
2014
36
Primary thyroid lymphoma: case series with review of literature. ( 25332615 )
2014
37
Aggressive primary thyroid lymphoma: imaging features of two elderly patients. ( 25060184 )
2014
38
Primary thyroid lymphoma: A rare disease. ( 25745292 )
2014
39
Diagnosing thyroid lymphoma: steroid administration may result in rapid improvement of dyspnea : a report of two cases. ( 24696693 )
2014
40
Primary thyroid lymphoma. ( 24935697 )
2014
41
Fine needle cytology and flow cytometry in hashimoto thyroiditis and primary thyroid lymphoma. ( 24642841 )
2014
42
Identification of primary thyroid lymphoma with medical imaging: A case report and review of the literature. ( 25364417 )
2014
43
Rituximab-including combined modality treatment for primary thyroid lymphoma: an effective regimen for elderly patients. ( 24547778 )
2014
44
Primary thyroid lymphoma: a series of two cases and review of literature. ( 24772759 )
2013
45
Patterns of care and treatment outcomes for primary thyroid lymphoma: a single institution study. ( 24501704 )
2013
46
Thyroid lymphoma incidentally detected by 18F-fluorocholine (FCH) PET/CT. ( 23856826 )
2013
47
Thyroid lymphoma: recent advances in diagnosis and optimal management strategies. ( 23881987 )
2013
48
Thyroid lymphoma: diagnostic pitfalls on pre-operative ago-biopsy. ( 23134840 )
2013
49
A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma. ( 24005594 )
2013
50
Tracheal invasion and perforation from advanced primary thyroid lymphoma: a case report and literature review. ( 23702317 )
2013

Variations for Thyroid Lymphoma

Expression for Thyroid Lymphoma

Search GEO for disease gene expression data for Thyroid Lymphoma.

Pathways for Thyroid Lymphoma

Pathways related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 CCNA2 CCNB1 TNF TP53
2
Show member pathways
12.69 CCNA2 CCNB1 TP53 TP73
3
Show member pathways
12.49 CCNA2 IL7 IL7R TNF
4
Show member pathways
12.42 CCNA2 CCNB1 TP53
5
Show member pathways
12.39 CCNA2 IL7 IL7R TNF TP53
6
Show member pathways
12.35 CCNA2 CCNB1 TP53
7
Show member pathways
12.23 CCNA2 CCNB1 TP53
8
Show member pathways
12.15 CCNB1 TP53 TP73
9 12.13 CCNA2 CCNB1 TP53
10
Show member pathways
12.12 CCNA2 CCNB1 TP53
11 12.04 CCNA2 TNF TP53
12 12.03 CCNA2 CCNB1 TP53 TP73
13 11.9 CCNA2 CCNB1 TP53
14 11.79 CCNB1 TP53 TP73
15
Show member pathways
11.77 CCNA2 CCNB1 TP53
16 11.72 IL7 IL7R TNF
17
Show member pathways
11.64 CCNA2 CCNB1 TP53
18 11.6 IL7 IL7R TNF
19 11.52 CCNA2 CCNB1 TP53
20
Show member pathways
11.48 CCNB1 TP53 TP73
21 11.44 CCNA2 TP53
23 11.4 CCNA2 CCNB1
24 11.4 IL7 IL7R TNF
25
Show member pathways
11.32 IL7 IL7R
26
Show member pathways
11.3 CCNB1 TP53
27 11.29 CCNA2 TP53
28 11.29 TNF TP53
29
Show member pathways
11.18 CCNA2 CCNB1
30 11.14 CCNA2 CCNB1
31 11.12 TNF TP73
32 11.12 IL7 TNF
33 11.05 IL7 TNF
34 11.02 IL7 IL7R
35
Show member pathways
10.89 TP53 TP73
36 10.84 CCNA2 TNF TP53
37 10.82 CCNB1 TP53
38 10.3 CCNA2 CCNB1 TP53

GO Terms for Thyroid Lymphoma

Cellular components related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCNA2 CCNB1

Biological processes related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.78 TNF TP53 TP73
2 cell cycle GO:0007049 9.73 CCNA2 CCNB1 TP53 TP73
3 negative regulation of gene expression GO:0010629 9.71 CCNB1 PICALM TNF
4 positive regulation of cell proliferation GO:0008284 9.67 CCNA2 CCNB1 IL7 IL7R
5 humoral immune response GO:0006959 9.61 IL7 TNF
6 positive regulation of cell cycle GO:0045787 9.6 CCNA2 CCNB1
7 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0006977 9.59 CCNB1 TP53
8 positive regulation of fibroblast proliferation GO:0048146 9.58 CCNA2 CCNB1
9 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 TNF TP73
10 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.57 CCNA2 CCNB1
11 regulation of mitotic nuclear division GO:0007088 9.56 CCNA2 CCNB1
12 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.55 IL7 TNF
13 protein tetramerization GO:0051262 9.52 TP53 TP73
14 interleukin-7-mediated signaling pathway GO:0038111 9.51 IL7 IL7R
15 cellular response to hypoxia GO:0071456 9.5 CCNA2 CCNB1 TP53
16 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.49 TP53 TP73
17 positive regulation of cell cycle arrest GO:0071158 9.48 TP53 TP73
18 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway GO:1900740 9.46 TP53 TP73
19 protein-containing complex assembly GO:0065003 9.43 CCNB1 PICALM TP53
20 positive regulation of chemokine production GO:0032722 9.4 IL7 TNF
21 cellular response to organic cyclic compound GO:0071407 9.33 CCNA2 CCNB1 TNF
22 cytokine-mediated signaling pathway GO:0019221 9.26 IL7 IL7R TNF TP53
23 positive regulation of transcription, DNA-templated GO:0045893 9.02 CCNA2 PICALM TNF TP53 TP73

Molecular functions related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 9.16 CCNA2 CCNB1
2 transcription regulatory region DNA binding GO:0044212 9.13 TNF TP53 TP73
3 protein kinase binding GO:0019901 8.92 CCNA2 CCNB1 TP53 TP73

Sources for Thyroid Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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