MCID: THY009
MIFTS: 46

Thyroid Lymphoma

Categories: Blood diseases, Rare diseases, Cancer diseases, Immune diseases, Endocrine diseases

Aliases & Classifications for Thyroid Lymphoma

Summaries for Thyroid Lymphoma

MalaCards based summary : Thyroid Lymphoma is related to hashimoto thyroiditis and lymphoma. An important gene associated with Thyroid Lymphoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are Cell Cycle, Mitotic and Cellular Senescence (REACTOME). Affiliated tissues include thyroid, b cells and colon, and related phenotypes are goiter and lymphoma

Wikipedia : 76 Thyroid lymphoma is a rare malignant tumor constituting 1% to 2% of all thyroid malignancies and less... more...

Related Diseases for Thyroid Lymphoma

Diseases related to Thyroid Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 hashimoto thyroiditis 11.3
2 lymphoma 10.7
3 thyroiditis 10.7
4 splenic diffuse red pulp small b-cell lymphoma 10.5 CCNA2 TP53
5 brain stem astrocytic neoplasm 10.4 CDKN2A TP53
6 keratinizing squamous cell carcinoma 10.4 CDKN2A TP53
7 spitz nevus 10.4 CDKN2A TP53
8 bladder carcinoma in situ 10.4 CDKN2A TP53
9 bartholin's gland benign neoplasm 10.4 CDKN2A TP53
10 vulva squamous cell carcinoma 10.4 CDKN2A TP53
11 nasal cavity adenocarcinoma 10.3 CDKN2A TP53
12 bone squamous cell carcinoma 10.3 CDKN2A TP53
13 anal squamous cell carcinoma 10.3 CDKN2A TP53
14 glycogen-rich clear cell breast carcinoma 10.3 CDKN2A TP53
15 gastric adenosquamous carcinoma 10.3 CDKN2A TP53
16 oral leukoplakia 10.3 CDKN2A TP53
17 anogenital venereal wart 10.3 CDKN2A TP53
18 megaesophagus 10.3 CDKN2A TP53
19 cervix uteri carcinoma in situ 10.3 CDKN2A TP53
20 schneiderian carcinoma 10.3 CDKN2A TP53
21 meningeal melanomatosis 10.3 CDKN2A TP53
22 dedifferentiated liposarcoma 10.3 CDKN2A TP53
23 oropharynx cancer 10.3 CDKN2A TP53
24 endocervical adenocarcinoma 10.3 CDKN2A TP53
25 cervix small cell carcinoma 10.3 CDKN2A TP53
26 necrotizing sialometaplasia 10.3 CDKN2A TP53
27 basaloid squamous cell carcinoma 10.3 CDKN2A TP53
28 biliary tract neoplasm 10.3 CDKN2A TP53
29 inverted papilloma 10.3 CDKN2A TP53
30 optic nerve neoplasm 10.3 CDKN2A TP53
31 recessive dystrophic epidermolysis bullosa 10.3 CDKN2A TP53
32 vulva cancer 10.3 CDKN2A TP53
33 squamous cell papilloma 10.3 CDKN2A TP53
34 pre-malignant neoplasm 10.2 CDKN2A TP53
35 juvenile pilocytic astrocytoma 10.2 CDKN2A TP53
36 barrett's adenocarcinoma 10.2 CDKN2A TP53
37 tenosynovial giant cell tumor 10.2 CDKN2A CDKN2B
38 cervix carcinoma 10.2 CDKN2A TP53
39 gastrointestinal system benign neoplasm 10.2 CDKN2A TP53
40 atypical neurofibroma 10.2 CDKN2A CDKN2B
41 skin squamous cell carcinoma 10.2 CDKN2A TP53
42 cellular schwannoma 10.2 CDKN2A TP53
43 penile cancer 10.2 CDKN2A TP53
44 pancreatic ductal carcinoma 10.2 CDKN2A TP53
45 bladder squamous cell carcinoma 10.2 CDKN2A TP53
46 ewing's family of tumors 10.2 CDKN2A CDKN2B
47 in situ carcinoma 10.2 CDKN2A TP53
48 central nervous system lymphoma 10.1 CDKN2A TP53
49 retinal cancer 10.1 CDKN2A TP53
50 pharynx cancer 10.1 CDKN2A TP53

Graphical network of the top 20 diseases related to Thyroid Lymphoma:



Diseases related to Thyroid Lymphoma

Symptoms & Phenotypes for Thyroid Lymphoma

Human phenotypes related to Thyroid Lymphoma:

59 32 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 goiter 59 32 obligate (100%) Obligate (100%) HP:0000853
2 lymphoma 59 32 obligate (100%) Obligate (100%) HP:0002665
3 broad neck 59 32 hallmark (90%) Very frequent (99-80%) HP:0000475
4 hypothyroidism 59 32 frequent (33%) Frequent (79-30%) HP:0000821
5 hashimoto thyroiditis 59 32 frequent (33%) Frequent (79-30%) HP:0000872
6 hoarse voice 59 32 frequent (33%) Frequent (79-30%) HP:0001609
7 dysphagia 59 32 frequent (33%) Frequent (79-30%) HP:0002015
8 lymphadenopathy 59 32 frequent (33%) Frequent (79-30%) HP:0002716
9 upper airway obstruction 59 32 frequent (33%) Frequent (79-30%) HP:0002781
10 stridor 59 32 frequent (33%) Frequent (79-30%) HP:0010307
11 hyperthyroidism 59 32 occasional (7.5%) Occasional (29-5%) HP:0000836
12 pain 59 32 occasional (7.5%) Occasional (29-5%) HP:0012531
13 respiratory distress 59 32 very rare (1%) Very rare (<4-1%) HP:0002098
14 dyspnea 59 Frequent (79-30%)

MGI Mouse Phenotypes related to Thyroid Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 CDKN2B IL7 PICALM TNF TP53 CCNA2
2 embryo MP:0005380 9.72 CDKN2A PICALM TNF TP53 CCNA2
3 immune system MP:0005387 9.7 CDKN2A CDKN2B IL7 PICALM TNF TP53
4 integument MP:0010771 9.35 CDKN2A CDKN2B PICALM TNF TP53
5 no phenotypic analysis MP:0003012 9.02 CDKN2A CDKN2B IL7 TNF TP53

Drugs & Therapeutics for Thyroid Lymphoma

Search Clinical Trials , NIH Clinical Center for Thyroid Lymphoma

Genetic Tests for Thyroid Lymphoma

Anatomical Context for Thyroid Lymphoma

MalaCards organs/tissues related to Thyroid Lymphoma:

41
Thyroid, B Cells, Colon, T Cells

Publications for Thyroid Lymphoma

Articles related to Thyroid Lymphoma:

(show top 50) (show all 191)
# Title Authors Year
1
Primary Thyroid Lymphoma: External Beam Radiation Therapy Induced Thyroiditis Mimics Residual Disease on Serial<sup>18</sup>F-FDG PET/CT Imaging. ( 29393054 )
2018
2
Primary thyroid lymphoma: a rare but challenging diagnosis. ( 28581452 )
2017
3
A Review of Primary Thyroid Lymphoma: Molecular Factors, Diagnosis and Management. ( 29058491 )
2017
4
Errata:Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry [Endocrine Journal Vol. 64 (9): 859-865, 2017]. ( 29081471 )
2017
5
Eleven patients with primary thyroid lymphoma: a single center experience ( 29151299 )
2017
6
Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma. ( 29268549 )
2017
7
Preoperative diagnostic algorithm of primary thyroid lymphoma using ultrasound, aspiration cytology, and flow cytometry. ( 28690277 )
2017
8
Primary thyroid lymphoma: A case report and review of the literature. ( 28053701 )
2017
9
Diagnosis and Clinical Analysis of Primary Thyroid Lymphoma. ( 28695809 )
2017
10
Efficacy of Fine-Needle Aspiration Cytology in the Diagnosis of Primary Thyroid Lymphoma for Elderly Adults. ( 27557116 )
2016
11
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. ( 26614433 )
2016
12
Primary thyroid lymphoma. ( 26985163 )
2016
13
Residual FDG uptake of primary thyroid lymphoma after treatment may overestimate residual lymphoma. ( 27614754 )
2016
14
Primary Thyroid Lymphoma: Clinicopathologic Characteristics and Therapeutic Outcomes of Six Cases in Morocco. ( 28191800 )
2016
15
Primary thyroid lymphoma presenting as dermatomyositis: a first case and review of the literature. ( 27126096 )
2016
16
Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma. ( 26608372 )
2016
17
Development of Primary Thyroid Lymphoma during an Ultrasonographic Follow-up of Hashimoto's Thyroiditis: A Report of 9 Cases. ( 27086809 )
2016
18
Clinical Presentation and Diagnostic Challenges of Thyroid Lymphoma: A Cohort Study. ( 27256107 )
2016
19
Pathology Verified Concomitant Papillary Thyroid Carcinoma in the Sonographically Suspected Thyroid Lymphoma: A Case Report. ( 28031089 )
2016
20
Primary thyroid lymphoma: The two ends of the spectrum. ( 26416071 )
2015
21
Complete resolution of autoimmune thyroiditis after R-CHOP in a patient with thyroid lymphoma. ( 26687264 )
2015
22
Evaluation of primary thyroid lymphoma by ultrasonography combined with contrast-enhanced ultrasonography: A pilot study. ( 26960472 )
2015
23
Primary thyroid lymphoma: multi-slice computed tomography findings. ( 25735344 )
2015
24
Hoarseness: an unusual presentation of primary thyroid lymphoma with laryngeal infiltration. ( 26411267 )
2015
25
Core needle biopsy could reduce diagnostic surgery in patients with anaplastic thyroid cancer or thyroid lymphoma. ( 26201291 )
2015
26
Primary thyroid lymphoma has different sonographic and color Doppler features compared to nodular goiter. ( 25614405 )
2015
27
Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study. ( 26665123 )
2015
28
12 cases of primary thyroid lymphoma in China. ( 25736543 )
2015
29
Thyroid lymphoma on a background of Hashimoto's thyroiditis: PET/CT appearances. ( 24679651 )
2014
30
Hypothyroidism after radiotherapy for primary thyroid lymphoma. ( 25075081 )
2014
31
Non-Hodgkin's thyroid lymphoma associated with Hashimoto's thyroiditis. ( 24864614 )
2014
32
Sonographic appearance of primary thyroid lymphoma-preliminary experience. ( 25474402 )
2014
33
Primary thyroid lymphoma: case series with review of literature. ( 25332615 )
2014
34
Aggressive primary thyroid lymphoma: imaging features of two elderly patients. ( 25060184 )
2014
35
Primary thyroid lymphoma: A rare disease. ( 25745292 )
2014
36
Diagnosing thyroid lymphoma: steroid administration may result in rapid improvement of dyspnea : a report of two cases. ( 24696693 )
2014
37
Primary thyroid lymphoma. ( 24935697 )
2014
38
Fine needle cytology and flow cytometry in hashimoto thyroiditis and primary thyroid lymphoma. ( 24642841 )
2014
39
Identification of primary thyroid lymphoma with medical imaging: A case report and review of the literature. ( 25364417 )
2014
40
Rituximab-including combined modality treatment for primary thyroid lymphoma: an effective regimen for elderly patients. ( 24547778 )
2014
41
Primary thyroid lymphoma: a series of two cases and review of literature. ( 24772759 )
2013
42
Patterns of care and treatment outcomes for primary thyroid lymphoma: a single institution study. ( 24501704 )
2013
43
Thyroid lymphoma incidentally detected by 18F-fluorocholine (FCH) PET/CT. ( 23856826 )
2013
44
Thyroid lymphoma: recent advances in diagnosis and optimal management strategies. ( 23881987 )
2013
45
Thyroid lymphoma: diagnostic pitfalls on pre-operative ago-biopsy. ( 23134840 )
2013
46
A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma. ( 24005594 )
2013
47
Tracheal invasion and perforation from advanced primary thyroid lymphoma: a case report and literature review. ( 23702317 )
2013
48
Ulcerative colitis associated with extranodal marginal zone B-cell thyroid lymphoma of mucosa-associated lymphoid tissue and Hashimoto thyroiditis: description of a case. ( 24714310 )
2013
49
Primary thyroid lymphoma: a clinical review. ( 23714679 )
2013
50
Clinicopathologic study and outcome analysis of thyroid lymphomas: experience from a tertiary cancer center. ( 22368156 )
2013

Variations for Thyroid Lymphoma

Expression for Thyroid Lymphoma

Search GEO for disease gene expression data for Thyroid Lymphoma.

Pathways for Thyroid Lymphoma

Pathways related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.15 CCNA2 CCNB1 CDKN2A CDKN2B TP53
2
Show member pathways
12.9 CCNA2 CDKN2A CDKN2B TP53
3
Show member pathways
12.73 CCNA2 IL7 TNF TP53
4
Show member pathways
12.7 CCNA2 CCNB1 CDKN2A TP53
5 12.56 CDKN2A CDKN2B IL7 TP53
6
Show member pathways
12.35 CCNA2 TNF TP53
7 12.25 CCNA2 CCNB1 CDKN2A TP53
8
Show member pathways
12.24 CCNA2 CCNB1 CDKN2A CDKN2B TP53
9
Show member pathways
12.22 CCNA2 CCNB1 TP53
10
Show member pathways
12.16 CCNB1 CDKN2A TP53
11 12.16 CDKN2A CDKN2B TNF TP53
12 12.04 CCNA2 CDKN2A CDKN2B TP53
13 12.01 CCNA2 CCNB1 CDKN2A CDKN2B TP53
14
Show member pathways
11.98 CCNA2 CDKN2A CDKN2B
15
Show member pathways
11.9 CCNA2 CCNB1 CDKN2A CDKN2B TP53
16
Show member pathways
11.77 CCNA2 CCNB1 TP53
17
Show member pathways
11.71 CCNA2 CCNB1 TP53
18 11.63 CCNA2 CCNB1 TP53
19
Show member pathways
11.53 CCNA2 CDKN2A TP53
20 11.4 CCNA2 CCNB1
21 11.4 CDKN2A TP53
22 11.31 CDKN2B TP53
23
Show member pathways
11.3 CCNB1 TP53
24 11.29 CCNA2 TP53
25 11.28 TNF TP53
26 11.23 CCNA2 CCNB1 CDKN2A CDKN2B TP53
27
Show member pathways
11.17 CCNA2 CCNB1
28 11.14 CCNA2 CCNB1
29 11.12 IL7 TNF
30 11.09 CCNA2 CCNB1 TP53
31 11.08 IL7 TNF
32 11.05 CDKN2A CDKN2B TP53
33 10.96 CCNA2 CDKN2A TNF TP53
34 10.92 CDKN2A TP53
35
Show member pathways
10.91 CDKN2A TP53
36 10.83 CCNB1 TP53

GO Terms for Thyroid Lymphoma

Biological processes related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.72 IL7 TNF TP53
2 negative regulation of gene expression GO:0010629 9.7 CCNB1 PICALM TNF
3 cell cycle arrest GO:0007050 9.65 CDKN2A CDKN2B TP53
4 G2/M transition of mitotic cell cycle GO:0000086 9.63 CCNA2 CCNB1 CDKN2B
5 protein-containing complex assembly GO:0065003 9.58 CCNB1 PICALM TP53
6 positive regulation of fibroblast proliferation GO:0048146 9.56 CCNA2 CCNB1
7 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 9.54 IL7 TNF
8 cellular response to hypoxia GO:0071456 9.54 CCNA2 CCNB1 TP53
9 positive regulation of chemokine production GO:0032722 9.51 IL7 TNF
10 negative regulation of phosphorylation GO:0042326 9.49 CDKN2A CDKN2B
11 replicative senescence GO:0090399 9.43 CDKN2A TP53
12 Ras protein signal transduction GO:0007265 9.43 CCNA2 CDKN2A TP53
13 cell cycle GO:0007049 9.35 CCNA2 CCNB1 CDKN2A CDKN2B TP53
14 cellular response to organic cyclic compound GO:0071407 9.33 CCNA2 CCNB1 TNF
15 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.32 CDKN2A CDKN2B
16 positive regulation of transcription, DNA-templated GO:0045893 9.02 CCNA2 CDKN2A PICALM TNF TP53

Molecular functions related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.16 CDKN2A TP53
2 protein kinase binding GO:0019901 9.02 CCNA2 CCNB1 CDKN2A CDKN2B TP53
3 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 8.96 CDKN2A CDKN2B

Sources for Thyroid Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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