MCID: THY009
MIFTS: 44

Thyroid Lymphoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases, Immune diseases, Rare diseases

Aliases & Classifications for Thyroid Lymphoma

MalaCards integrated aliases for Thyroid Lymphoma:

Name: Thyroid Lymphoma 12 58 15 70

Classifications:

Orphanet: 58  
Rare endocrine diseases
Rare haematological diseases


Summaries for Thyroid Lymphoma

Disease Ontology : 12 A thyroid gland cancer that has material basis in lymphocytes.

MalaCards based summary : Thyroid Lymphoma is related to b-cell lymphoma and lymphoma, non-hodgkin, familial. An important gene associated with Thyroid Lymphoma is TP53 (Tumor Protein P53), and among its related pathways/superpathways are ERK Signaling and Regulation of TP53 Activity. Affiliated tissues include thyroid, colon and breast, and related phenotypes are lymphoma and goiter

Wikipedia : 73 Thyroid lymphoma is a rare cancer constituting 1% to 2% of all thyroid cancers and less than 2% of... more...

Related Diseases for Thyroid Lymphoma

Diseases related to Thyroid Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 b-cell lymphoma 30.6 TP53 FAS CDKN2B CDKN2A
2 lymphoma, non-hodgkin, familial 30.0 TP53 IL7 FAS CDKN2B
3 adult t-cell leukemia 29.7 TP53 FAS CDKN2A
4 subacute thyroiditis 29.5 TNF TG
5 burkitt lymphoma 28.8 TP53 TNF IL7 FAS CDKN2B CDKN2A
6 leukemia, chronic lymphocytic 28.4 TP53 TNF IL7 FAS CDKN2B CCNA2
7 hashimoto thyroiditis 11.1
8 thyroiditis 10.8
9 diffuse large b-cell lymphoma 10.6
10 lymphoma 10.6
11 goiter 10.5
12 lymphoma, mucosa-associated lymphoid type 10.4
13 thyroid carcinoma 10.4
14 vulvar intraepithelial neoplasia 10.3 TP53 CDKN2A
15 esophagus verrucous carcinoma 10.3 TP53 CDKN2A
16 ovarian seromucinous carcinoma 10.3 TP53 CDKN2A
17 human papillomavirus infectious disease 10.3 TP53 CDKN2A
18 spitz nevus 10.3 TP53 CDKN2A
19 squamous cell papilloma 10.3 TP53 CDKN2A
20 penile benign neoplasm 10.3 TP53 CDKN2A
21 bizarre leiomyoma 10.3 TP53 CDKN2A
22 lymphoma, hodgkin, classic 10.3
23 adult malignant schwannoma 10.3 TP53 CDKN2A
24 supraglottis cancer 10.3 TP53 CDKN2A
25 suppressor of tumorigenicity 3 10.3 TP53 CDKN2A
26 splenic diffuse red pulp small b-cell lymphoma 10.3 TP53 CCNA2
27 localized osteosarcoma 10.3 TP53 CDKN2A
28 malignant exocrine pancreas neoplasm 10.3 TP53 CDKN2A
29 chronic cervicitis 10.3 TP53 CDKN2A
30 apocrine adenosis of breast 10.3 TP53 CCNA2
31 bladder clear cell adenocarcinoma 10.3 TP53 CDKN2A
32 keratinizing squamous cell carcinoma 10.3 TP53 CDKN2A
33 male reproductive organ benign neoplasm 10.3 TP53 CDKN2A
34 malignant spiradenoma 10.3 TP53 CDKN2A
35 bile duct adenoma 10.3 TP53 CDKN2A
36 vulva squamous cell carcinoma 10.3 TP53 CDKN2A
37 vaginal cancer 10.3 TP53 CDKN2A
38 nasal cavity adenocarcinoma 10.3 TP53 CDKN2A
39 hypothyroidism 10.3
40 bone squamous cell carcinoma 10.3 TP53 CDKN2A
41 gliofibroma 10.3 TP53 CDKN2A
42 nasal cavity cancer 10.3 TP53 CDKN2A
43 prostate squamous cell carcinoma 10.3 TP53 CDKN2A
44 borst-jadassohn intraepidermal carcinoma 10.3 TP53 CDKN2A
45 familial retinoblastoma 10.3 TP53 CDKN2A
46 neurofibrosarcoma 10.3 TP53 CDKN2A
47 laryngeal benign neoplasm 10.2 TP53 CDKN2A
48 vulvar disease 10.2 TP53 CDKN2A
49 acanthoma 10.2 TP53 CDKN2A
50 vulvar dystrophy 10.2 TP53 CDKN2A

Graphical network of the top 20 diseases related to Thyroid Lymphoma:



Diseases related to Thyroid Lymphoma

Symptoms & Phenotypes for Thyroid Lymphoma

Human phenotypes related to Thyroid Lymphoma:

58 31 (show all 14)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lymphoma 58 31 obligate (100%) Obligate (100%) HP:0002665
2 goiter 58 31 obligate (100%) Obligate (100%) HP:0000853
3 broad neck 58 31 hallmark (90%) Very frequent (99-80%) HP:0000475
4 dysphagia 58 31 frequent (33%) Frequent (79-30%) HP:0002015
5 hypothyroidism 58 31 frequent (33%) Frequent (79-30%) HP:0000821
6 hashimoto thyroiditis 58 31 frequent (33%) Frequent (79-30%) HP:0000872
7 hoarse voice 58 31 frequent (33%) Frequent (79-30%) HP:0001609
8 stridor 58 31 frequent (33%) Frequent (79-30%) HP:0010307
9 lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002716
10 upper airway obstruction 58 31 frequent (33%) Frequent (79-30%) HP:0002781
11 hyperthyroidism 58 31 occasional (7.5%) Occasional (29-5%) HP:0000836
12 pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0012531
13 respiratory distress 58 31 very rare (1%) Very rare (<4-1%) HP:0002098
14 dyspnea 58 Frequent (79-30%)

MGI Mouse Phenotypes related to Thyroid Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.86 CDKN2A CDKN2B FAS IL7 IL7R TG
2 hematopoietic system MP:0005397 9.81 CCNA2 CDKN2A CDKN2B FAS IL7 IL7R
3 immune system MP:0005387 9.61 CCNA2 CDKN2A CDKN2B FAS IL7 IL7R
4 neoplasm MP:0002006 9.1 CDKN2A CDKN2B FAS IL7R TNF TP53

Drugs & Therapeutics for Thyroid Lymphoma

Search Clinical Trials , NIH Clinical Center for Thyroid Lymphoma

Genetic Tests for Thyroid Lymphoma

Anatomical Context for Thyroid Lymphoma

MalaCards organs/tissues related to Thyroid Lymphoma:

40
Thyroid, Colon, Breast, Skin, Bone Marrow, Lymph Node, Eye

Publications for Thyroid Lymphoma

Articles related to Thyroid Lymphoma:

(show top 50) (show all 408)
# Title Authors PMID Year
1
[Ultrasound-guided core-needle biopsy diagnosis of thyroid T-cell lymphoma: a case report]. 61
33794618 2021
2
Diagnostic and prognostic value of a 7-panel mutation testing in thyroid nodules with indeterminate cytology: the SWEETMAC study. 61
32638211 2021
3
Clinical prognosis and bioinformatic analysis of primary thyroid lymphoma. 61
33578562 2021
4
Non-Hodgkin lymphoma of the thyroid in a patient with hyperthyroidism. 61
33552422 2021
5
Diagnosis methods and treatment strategy for primary thyroid lymphoma: a retrospective analysis of 41 cases in China. 61
32809992 2021
6
The diagnosis of primary thyroid lymphoma by fine-needle aspiration, cell block, and immunohistochemistry technique. 61
32609434 2020
7
Prevalence and diagnostic challenges of thyroid lymphoma: a multi-institutional study in non-Western countries. 61
32641619 2020
8
Hashimoto's thyroiditis and primary thyroid lymphoma. 61
31917415 2020
9
t(3;14)(p14.1;q32)/FOXP1-IGH translocation in thyroid extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). 61
32534365 2020
10
Esophageal perforation in case of thyroid lymphoma. 61
32695385 2020
11
Progressively Enlarging Goiter: Case Reports of Primary Thyroid Lymphoma and Literature Review. 61
32474859 2020
12
Riedel's thyroiditis as a diagnostic dilemma - A case report and review of the literature. 61
32140224 2020
13
Clinical features associated with high pathological grade in primary thyroid lymphoma. 61
31974002 2020
14
Hashimoto Thyroiditis in Primary Thyroid Non-Hodgkin Lymphoma. 61
31584614 2020
15
Spontaneous Regression of Primary Thyroid Lymphoma: Two Rarities at the Same Time. 61
30632122 2020
16
Radical surgery for primary thyroid lymphoma in a Filipino female: Report of a case and review of literature. 61
32979830 2020
17
Contrast-Enhanced Ultrasound in the Differential Diagnosis of Primary Thyroid Lymphoma and Nodular Hashimoto's Thyroiditis in a Background of Heterogeneous Parenchyma. 61
33489895 2020
18
Diffuse large B-cell and follicular lymphoma presenting as a slowly growing compressive goiter: A case report and literature review. 61
32698301 2020
19
Flow cytometric, gene rearrangement, and karyotypic analyses of 110 cases of primary thyroid lymphoma: a single-institutional experience in Japan. 61
31484843 2019
20
Dyspnea after thyroidectomy induced by intratracheal lymphoma: A case report. 61
31423311 2019
21
Ultrasonography in the Diagnosis and Monitoring of Therapy for Primary Thyroid Lymphoma. 61
30601440 2019
22
Down syndrome with primary thyroid diffuse large B-cell lymphoma and Hashimoto thyroiditis: A CARE compliant case report. 61
31464950 2019
23
[Comparisons of clinical characteristics and prognosis between patients with primary and secondary thyroid lymphoma]. 61
32397019 2019
24
Primary thyroid lymphoma: A series from a tertiary care center in Northern India. 61
31169238 2019
25
Approach to primary thyroid lymphoma: case series. 61
32550320 2019
26
R-CHOP-Associated Graves' Hyperthyroidism. 61
31543772 2019
27
Fine-needle aspiration to diagnose primary thyroid lymphomas: a systematic review and meta-analysis. 61
30566902 2019
28
A Review of Primary Thyroid Lymphoma: Molecular Factors, Diagnosis and Management. 61
29058491 2019
29
Primary Thyroid Lymphoma: An Analysis of the National Cancer Database. 61
31057992 2019
30
[A retrospective analysis of 12 cases of primary thyroid lymphoma]. 61
30773562 2019
31
Is ultrasound combined with computed tomography useful for distinguishing between primary thyroid lymphoma and Hashimoto's thyroiditis? 61
31529457 2019
32
[Clinicopathological features and treatment outcome of 37 cases of primary thyroid lymphoma]. 61
30400705 2018
33
Importance of combined approach of investigations for detection of asymptomatic Hashimoto Thyroiditis in early stage. 61
30078965 2018
34
Cytodiagnosis of Primary Thyroid Lymphoma Coincident with Unnoticed Papillary Thyroid Carcinoma: A Case Report and Review of the Literature. 61
30089952 2018
35
Jejunal Intussusception: A Rare Manifestation of a Primary Thyroid Non-Hodgkin Lymphoma. 61
30079283 2018
36
Primary Diffuse B-Cell Thyroid Lymphoma: Case Report and Literature Review. 61
30140214 2018
37
Calcifications in Thyroid Tumors on Ultrasonography: Calcification Types and Relationship with Histopathological Type. 61
30250940 2018
38
Primary Thyroid Lymphoma: External Beam Radiation Therapy Induced Thyroiditis Mimics Residual Disease on Serial 18F-FDG PET/CT Imaging. 61
29393054 2018
39
Lymphomas and thyroid: Bridging the gap. 61
29484690 2018
40
Long-Term Outcomes of 107 Cases of Primary Thyroid Mucosa-Associated Lymphoid Tissue Lymphoma at a Single Medical Institution in Japan. 61
29165612 2018
41
Clinicopathological characteristics and prognostic factors for primary thyroid lymphoma: report on 28 Chinese patients and results of a population-based study. 61
30349374 2018
42
Concomitant papillary thyroid carcinoma and mucosa-associated lymphoid tissue thyroid lymphoma in the setting of Hashimoto thyroiditis. 61
31938434 2018
43
Primary thyroid MALToma- a rare diagnosis of an unassuming thyroid nodule. 61
29686785 2018
44
An investigation into symptoms, diagnosis, treatment, and treatment complications in patients with retrosternal goiter. 61
29915764 2018
45
When a Goitre is a Thyroid Lymphoma. 61
30756001 2018
46
Identification of Cytological Features Distinguishing Mucosa-Associated Lymphoid Tissue Lymphoma from Reactive Lymphoid Proliferation Using Thyroid Liquid-Based Cytology. 61
29597203 2018
47
Characteristics and natural course of hypoechoic thyroid lesions diagnosed as possible thyroid lymphomas by fine needle aspiration cytology. 61
29875824 2018
48
Coexistence of diffuse large B-cell lymphoma and papillary thyroid carcinoma in a patient affected by Hashimoto's thyroiditis. 61
29412392 2017
49
Eleven patients with primary thyroid lymphoma: a single center experience 61
29151299 2017
50
Comparison of sonographic characteristics of primary thyroid lymphoma and anaplastic thyroid carcinoma. 61
29268549 2017

Variations for Thyroid Lymphoma

Expression for Thyroid Lymphoma

Search GEO for disease gene expression data for Thyroid Lymphoma.

Pathways for Thyroid Lymphoma

Pathways related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 TP53 TNF IL7R IL7 FAS CDKN2B
2
Show member pathways
12.79 TP53 FAS CDKN2A CCNB1 CCNA2
3
Show member pathways
12.77 TP53 TNF IL7R IL7 FAS CCNA2
4
Show member pathways
12.74 TP53 TNF FAS CDKN2A CCNB1
5
Show member pathways
12.69 TP53 TNF FAS CCNA2
6
Show member pathways
12.64 TNF IL7R IL7 CCNA2
7
Show member pathways
12.57 TP53 TNF FAS CDKN2A
8
Show member pathways
12.56 TP53 FAS CCNB1 CCNA2
9
Show member pathways
12.54 TNF FAS CCNB1 CCNA2
10 12.37 TP53 CDKN2A CCNB1 CCNA2
11
Show member pathways
12.34 TP53 FAS CCNB1 CCNA2
12 12.22 TP53 IL7R IL7 FAS CDKN2B CDKN2A
13
Show member pathways
12.2 TP53 FAS CDKN2A CCNG2 CCNB1
14 12.16 TP53 CDKN2B CDKN2A CCNB1 CCNA2
15 12.15 TP53 CDKN2B CDKN2A CCNA2
16
Show member pathways
12.15 TP53 CDKN2B CDKN2A CCNG2 CCNB1 CCNA2
17
Show member pathways
12.12 TP53 CDKN2B CDKN2A CCNB1 CCNA2
18 12.06 TP53 TNF CDKN2B CDKN2A CCNA2
19 12.01 TP53 TNF FAS
20 11.95 TP53 FAS CCNB1
21
Show member pathways
11.91 IL7R CDKN2B CCNG2 CCNB1
22 11.88 TNF IL7R IL7
23 11.87 TP53 CDKN2A CCNG2
24 11.85 TP53 CDKN2B CDKN2A CCNB1 CCNA2
25
Show member pathways
11.83 CDKN2B CDKN2A CCNA2
26
Show member pathways
11.8 TP53 CCNB1 CCNA2
27 11.78 TNF IL7R IL7
28 11.73 TP53 CCNB1 CCNA2
29 11.67 TNF IL7R IL7
30
Show member pathways
11.61 TP53 CDKN2A CCNA2
31 11.6 TP53 FAS CDKN2A
32 11.34 TP53 TNF FAS
33 11.19 TP53 CDKN2B CDKN2A
34 11.18 TP53 CCNB1 CCNA2
35 11.14 TNF IL7
36 11.13 IL7R IL7
37
Show member pathways
11.01 TP53 CDKN2A
38 11.01 TP53 CDKN2A
39 10.94 TP53 CCNB1
40 10.73 TP53 TNF FAS CDKN2A CCNA2

GO Terms for Thyroid Lymphoma

Cellular components related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.8 CCNG2 CCNB1 CCNA2

Biological processes related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.9 TNF IL7R IL7 FAS
2 positive regulation of apoptotic process GO:0043065 9.81 TP53 TNF FAS CDKN2A
3 regulation of cell cycle GO:0051726 9.77 TP53 CCNG2 CCNB1
4 G2/M transition of mitotic cell cycle GO:0000086 9.75 CDKN2B CCNB1 CCNA2
5 cell cycle arrest GO:0007050 9.74 TP53 CDKN2B CDKN2A
6 cellular response to hypoxia GO:0071456 9.72 TP53 CCNB1 CCNA2
7 protein-containing complex assembly GO:0065003 9.71 TP53 FAS CCNB1
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.7 TP53 TNF FAS
9 positive regulation of gene expression GO:0010628 9.65 TP53 TNF IL7R IL7 CDKN2A
10 activation of cysteine-type endopeptidase activity involved in apoptotic process GO:0006919 9.63 TNF FAS CDKN2A
11 cellular senescence GO:0090398 9.61 CDKN2B CDKN2A
12 negative regulation of phosphorylation GO:0042326 9.58 CDKN2B CDKN2A
13 Ras protein signal transduction GO:0007265 9.58 TP53 CDKN2A CCNA2
14 replicative senescence GO:0090399 9.56 TP53 CDKN2A
15 cellular response to organic cyclic compound GO:0071407 9.54 TNF CCNB1 CCNA2
16 negative regulation of production of miRNAs involved in gene silencing by miRNA GO:1903799 9.49 TP53 TNF
17 response to salt stress GO:0009651 9.48 TP53 TNF
18 necroptotic signaling pathway GO:0097527 9.43 TNF FAS
19 cell cycle GO:0007049 9.43 TP53 CDKN2B CDKN2A CCNG2 CCNB1 CCNA2
20 mitotic cell cycle phase transition GO:0044772 9.33 CCNG2 CCNB1 CCNA2
21 T cell lineage commitment GO:0002360 9.32 TP53 IL7
22 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 8.92 CDKN2B CCNG2 CCNB1 CCNA2

Molecular functions related to Thyroid Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase binding GO:0019901 9.35 TP53 CDKN2B CDKN2A CCNB1 CCNA2
2 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0004861 9.26 CDKN2B CDKN2A
3 MDM2/MDM4 family protein binding GO:0097371 9.16 TP53 CDKN2A
4 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 8.8 CCNG2 CCNB1 CCNA2

Sources for Thyroid Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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