MCID: THY128
MIFTS: 47

Thyroid Tumor

Categories: Endocrine diseases, Rare diseases

Aliases & Classifications for Thyroid Tumor

MalaCards integrated aliases for Thyroid Tumor:

Name: Thyroid Tumor 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

UMLS via Orphanet 72 C0040136
Orphanet 58 ORPHA100087

Summaries for Thyroid Tumor

MalaCards based summary : Thyroid Tumor is related to thyroid gland papillary carcinoma and papillary carcinoma. An important gene associated with Thyroid Tumor is KRAS (KRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Nutrients and Trace Elements have been mentioned in the context of this disorder. Affiliated tissues include thyroid, breast and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Thyroid Tumor

Diseases related to Thyroid Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 366)
# Related Disease Score Top Affiliating Genes
1 thyroid gland papillary carcinoma 31.1 TG RET LGALS3
2 papillary carcinoma 31.1 TPO TG RET LGALS3 BRAF
3 goiter 30.8 TPO THRB TG RET LGALS3
4 follicular adenoma 30.7 TPO TG RET PTEN LGALS3 BRAF
5 thyroiditis 30.5 TPO THRB TG RET BRAF
6 multinodular goiter 30.3 TPO TG HRAS
7 hypothyroidism 30.3 TPO THRB TG RET BRAF
8 acute thyroiditis 30.3 TPO TG
9 thyroid carcinoma, familial medullary 30.3 TG RET PRKAR1A KRAS BRAF
10 hashimoto thyroiditis 30.1 TPO TG RET LGALS3 BRAF
11 adenoma 30.1 TP53 RET PRKAR1A PIK3CA LGALS3 KRAS
12 graves disease 1 30.1 TPO THRB TG
13 parathyroid adenoma 30.1 RET PRKAR1A LGALS3
14 toxic diffuse goiter 30.0 TPO TG
15 atypical follicular adenoma 29.9 TG TERT RET
16 parathyroid carcinoma 29.9 TERT RET LGALS3
17 thyroid gland follicular carcinoma 29.8 TP53 TG RET PTEN LGALS3 HRAS
18 small cell carcinoma 29.8 TP53 PTEN KRAS
19 plummer's disease 29.8 TPO THRB TG
20 fetal adenoma 29.7 TG NRAS
21 cowden syndrome 1 29.7 TP53 RET PTEN PIK3CA
22 nodular goiter 29.6 TPO TG RET LGALS3 HRAS BRAF
23 testicular germ cell tumor 29.6 TP53 PTEN HRAS
24 thyroid gland anaplastic carcinoma 29.5 TPO TP53 TG RET PTEN PIK3CA
25 hemangioma 29.3 TP53 RET PTEN KRAS
26 lipomatosis 29.1 PTEN PRKAR1A PIK3CA KRAS
27 papillary adenoma 29.1 TP53 KRAS HRAS
28 thyroid gland disease 29.0 TPO TP53 THRB TG RET PTEN
29 cowden syndrome 28.9 TP53 RET PTEN PRKAR1A PIK3CA HRAS
30 thyroid cancer, nonmedullary, 2 28.9 THRB TG PTEN NRAS LGALS3 HRAS
31 melanocytic nevus syndrome, congenital 28.9 PRKAR1A NRAS HRAS
32 thymoma 28.8 TP53 TG PIK3CA HRAS
33 neurofibromatosis, type iv, of riccardi 28.7 TP53 RET PTEN KRAS HRAS
34 thyroid carcinoma 28.6 TPO TP53 TG RET PTEN PIK3CA
35 schimmelpenning-feuerstein-mims syndrome 28.5 NRAS KRAS HRAS
36 adenoid cystic carcinoma 28.5 TP53 PTEN PIK3CA MMP2 KRAS HRAS
37 colon adenocarcinoma 28.3 TP53 PTEN PIK3CA MMP2 LGALS3 KRAS
38 differentiated thyroid carcinoma 28.2 TPO TP53 TG RET NRAS KRAS
39 myeloid leukemia 27.9 TP53 TERT NRAS KRAS HRAS
40 leukemia 27.7 TP53 TERT NRAS KRAS HRAS BRAF
41 melanoma, cutaneous malignant 1 27.4 TP53 TERT PTEN PIK3CA NRAS HRAS
42 adenocarcinoma 27.4 TP53 TIMP3 RET PTEN PIK3CA MMP2
43 sarcoma 27.4 TP53 RET PIK3CA NRAS KRAS HRAS
44 nevus, epidermal 27.4 PTEN PIK3CA NRAS KRAS HRAS FGFR2
45 renal cell carcinoma, nonpapillary 27.0 TP53 RET PTEN PIK3CA NRAS MMP2
46 pancreatic cancer 26.7 TP53 TERT RET PTEN PIK3CA MMP2
47 lung cancer susceptibility 3 26.2 TP53 TERT RET PTEN PIK3CA NRAS
48 prostate cancer 26.2 TP53 TIMP3 TERT PTEN PIK3CA MMP2
49 thyroid gland cancer 25.6 TPO TP53 TIMP3 THRB TG TERT
50 colorectal cancer 25.1 TP53 TIMP3 TERT RET PTEN PIK3CA

Graphical network of the top 20 diseases related to Thyroid Tumor:



Diseases related to Thyroid Tumor

Symptoms & Phenotypes for Thyroid Tumor

GenomeRNAi Phenotypes related to Thyroid Tumor according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 10.34 HRAS KRAS PIK3CA BRAF
2 Decreased viability GR00106-A-0 10.34 KRAS
3 Decreased viability GR00221-A-1 10.34 HRAS KRAS PIK3CA PRKAR1A RET NRAS
4 Decreased viability GR00221-A-2 10.34 HRAS KRAS PIK3CA PRKAR1A RET
5 Decreased viability GR00221-A-3 10.34 HRAS PRKAR1A NRAS
6 Decreased viability GR00221-A-4 10.34 PIK3CA PRKAR1A RET BRAF
7 Decreased viability GR00231-A 10.34 RET
8 Decreased viability GR00301-A 10.34 KRAS RET BRAF FGFR2
9 Decreased viability GR00342-S-1 10.34 FGFR2
10 Decreased viability GR00342-S-2 10.34 FGFR2
11 Decreased viability GR00342-S-3 10.34 FGFR2
12 Decreased viability GR00381-A-1 10.34 KRAS BRAF
13 Decreased viability GR00402-S-2 10.34 HRAS KRAS PIK3CA PRKAR1A RET BRAF
14 Decreased cell migration GR00055-A-1 9.35 BRAF HRAS KRAS PIK3CA PRKAR1A

MGI Mouse Phenotypes related to Thyroid Tumor:

45 (show all 28)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.55 BRAF FGFR2 HRAS KRAS LGALS3 MMP2
2 homeostasis/metabolism MP:0005376 10.5 BRAF FGFR2 HRAS KRAS LGALS3 MMP2
3 immune system MP:0005387 10.49 BRAF FGFR2 KRAS LGALS3 MMP2 NRAS
4 behavior/neurological MP:0005386 10.48 BRAF FGFR2 HRAS KRAS LGALS3 NRAS
5 hematopoietic system MP:0005397 10.48 BRAF FGFR2 KRAS LGALS3 MMP2 NRAS
6 cardiovascular system MP:0005385 10.47 BRAF FGFR2 HRAS KRAS LGALS3 MMP2
7 cellular MP:0005384 10.47 BRAF FGFR2 KRAS LGALS3 NRAS PIK3CA
8 endocrine/exocrine gland MP:0005379 10.47 BRAF FGFR2 HRAS KRAS NRAS PIK3CA
9 digestive/alimentary MP:0005381 10.46 BRAF FGFR2 HRAS KRAS LGALS3 NRAS
10 mortality/aging MP:0010768 10.44 BRAF FGFR2 HRAS KRAS LGALS3 MMP2
11 integument MP:0010771 10.33 BRAF FGFR2 HRAS KRAS LGALS3 NRAS
12 craniofacial MP:0005382 10.32 BRAF FGFR2 HRAS KRAS MMP2 NRAS
13 neoplasm MP:0002006 10.32 BRAF FGFR2 HRAS KRAS LGALS3 MMP2
14 nervous system MP:0003631 10.27 BRAF FGFR2 HRAS KRAS LGALS3 MMP2
15 embryo MP:0005380 10.26 BRAF FGFR2 KRAS NRAS PIK3CA PRKAR1A
16 adipose tissue MP:0005375 10.24 BRAF FGFR2 LGALS3 PIK3CA PRKAR1A PTEN
17 limbs/digits/tail MP:0005371 10.24 BRAF FGFR2 KRAS NRAS PTEN RET
18 muscle MP:0005369 10.24 BRAF FGFR2 KRAS MMP2 PIK3CA PRKAR1A
19 liver/biliary system MP:0005370 10.22 BRAF FGFR2 KRAS LGALS3 NRAS PRKAR1A
20 normal MP:0002873 10.18 BRAF FGFR2 HRAS KRAS MMP2 NIBAN1
21 hearing/vestibular/ear MP:0005377 10.06 BRAF FGFR2 KRAS THRB TP53 TPO
22 no phenotypic analysis MP:0003012 10.03 FGFR2 HRAS KRAS NRAS PIK3CA RET
23 reproductive system MP:0005389 10 BRAF FGFR2 KRAS LGALS3 PIK3CA PRKAR1A
24 respiratory system MP:0005388 10 BRAF FGFR2 HRAS KRAS LGALS3 MMP2
25 pigmentation MP:0001186 9.97 BRAF FGFR2 KRAS NRAS PRKAR1A PTEN
26 renal/urinary system MP:0005367 9.97 BRAF FGFR2 HRAS KRAS LGALS3 PTEN
27 skeleton MP:0005390 9.86 BRAF FGFR2 HRAS KRAS LGALS3 MMP2
28 vision/eye MP:0005391 9.4 BRAF FGFR2 KRAS MMP2 NRAS PIK3CA

Drugs & Therapeutics for Thyroid Tumor

Drugs for Thyroid Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Nutrients Phase 4
2 Trace Elements Phase 4
3 Anti-Infective Agents, Local Phase 4
4 Micronutrients Phase 4
5 Hemostatics Phase 3
6 Coagulants Phase 3
7
Iodine Approved, Investigational 7553-56-2 807
8
Remifentanil Approved 132875-61-7 60815
9
Dexmedetomidine Approved, Vet_approved 113775-47-6 68602 5311068
10
Desflurane Approved 57041-67-5 42113
11 cadexomer iodine
12 Anti-Infective Agents
13 Neurotransmitter Agents
14 Anesthetics
15 Adrenergic Agonists
16 Narcotics
17 Adrenergic alpha-2 Receptor Agonists
18 Analgesics, Non-Narcotic
19 Analgesics, Opioid
20 Anesthetics, General
21 Central Nervous System Depressants
22 Hypnotics and Sedatives
23 Anesthetics, Inhalation
24 Adrenergic Agents
25 Analgesics
26 Antiviral Agents
27 Deoxyglucose
28 Antimetabolites

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
2 Medico-economic Evaluation Comparing the Use of Ultrasonic Scissors to the Conventional Techniques of Haemostasis in Thyroid Surgery by Cervicotomy Unknown status NCT01551914 Phase 3
3 Radiofrequency Ablation for Low Risk Papillary Thyroid Cancer: A Pilot Study Unknown status NCT00103155 Phase 1
4 Clinical Benefits of Reduced Subcutaneous Dissection in Endoscopic Thyroidectomy Unknown status NCT01338597
5 Detection of Benign and Malignant Thyroid and Breast Tumors by Fourier Transform Infrared Spectrometry Unknown status NCT01668238
6 Purse String Suture for the Closure of Large Thyroidectomy Resulted in Better Cosmetics Completed NCT03035383
7 Significant Intracellular NIS Protein Associated With Low Levels of NIS Messenger RNA in Malignant Thyroid Tumors Completed NCT00459498
8 Levothyroxine Treatment in Thyroid Benign Nodular Goiter Completed NCT00552253 Levothyroxin treatment
9 Thyroid Cancer Among Chornobyl Clean-up Workers in Ukraine: Pilot Study Completed NCT01265381
10 Prospective and Retrospective Thyroid Cancer Database Recruiting NCT04031638
11 Clinical and Genetic Studies in Familial Non-Medullary Thyroid Cancer Recruiting NCT01109420
12 Significance of Single Center, Open and Prospective Evaluation of Contralateral Central Lymph Node Dissection in Unilateral cN0 Differentiated Thyroid Carcinoma. Recruiting NCT03845647
13 Effect of Dexmedetomidine Infusion for Postoperative Outcome and Smooth Emergence After Thyroidectomy Recruiting NCT02412150 Desflurane;Remifentanil;Dexmedetomidine;Normal saline
14 Diagnostic Significance of Single Center, Open and Prospective Evaluation of <Sup>18<Sup>F-FDG PET/CT Dynamic Imaging in Detecting Metastatic Central Lymph Nodes in Patients With Papillary Thyroid Cancer Recruiting NCT03830242
15 Integrated Cancer Repository for Cancer Research Recruiting NCT02012699
16 Longitudinal Assessment and Natural History Study of Children and Adults With MEN2A or MEN2B With or Without Medullary Thyroid Carcinoma Recruiting NCT01660984

Search NIH Clinical Center for Thyroid Tumor

Genetic Tests for Thyroid Tumor

Anatomical Context for Thyroid Tumor

MalaCards organs/tissues related to Thyroid Tumor:

40
Thyroid, Breast, Lung, Lymph Node, Skin, Thymus, Ovary

Publications for Thyroid Tumor

Articles related to Thyroid Tumor:

(show top 50) (show all 1413)
# Title Authors PMID Year
1
FOXE1 regulates migration and invasion in thyroid cancer cells and targets ZEB1. 61
31846430 2020
2
Mebendazole inhibits tumor growth and prevents lung metastasis in models of advanced thyroid cancer. 61
31846433 2020
3
SRY‑related HMG box‑2 role in anaplastic thyroid cancer aggressiveness is related to the fibronectin 1 and PI3K/AKT pathway. 61
31922212 2020
4
Thyroid tumor surveillance using ultrasound in childhood cancer survivors. 61
32017284 2020
5
Metastatic thyroid carcinoma presented as a large craniofacial mass: Case report and CT findings. 61
31798760 2020
6
Thyroid carcinomas that occur in familial adenomatous polyposis patients recurrently harbor somatic variants in APC, BRAF, and KTM2D. 61
32024448 2020
7
Staged surgical management of follicular thyroid carcinoma with extensive thrombus reaching up to right atrium - A case report. 61
31805428 2020
8
Comprehensive DNA Methylation Profiling Identifies Novel Diagnostic Biomarkers for Thyroid Cancer. 61
31797753 2020
9
Downregulating integrin subunit alpha 7 (ITGA7) promotes proliferation, invasion, and migration of papillary thyroid carcinoma cells through regulating epithelial-to-mesenchymal transition. 61
31942970 2020
10
Transnasal humidified rapid-insufflation ventilatory exchange can be utilized in tracheal stenosis caused by thyroid tumor. 61
31951920 2020
11
Effect of single-nucleotide polymorphism in TERT promoter on follicular thyroid tumor development. 61
31943533 2020
12
Oxygen reserve index (ORi™) contributes to prediction of hypoxemia and patient safety during tracheal stent insertion using rigid bronchoscopy: a case report. 61
30519896 2019
13
Thyroid Carcinoma Showing Thymus-Like Differentiation (CASTLE) with Tracheal Invasion: A Case Report. 61
31819030 2019
14
MOLECULAR PROFILE AND CLINICAL OUTCOMES IN DIFFERENTIATED THYROID CANCER PATIENTS PRESENTING WITH BONE METASTASIS. 61
31412230 2019
15
Long Non-coding RNA Expression in Anaplastic Thyroid Carcinomas. 61
31468286 2019
16
Adamantinoma-Like Ewing Sarcoma of the Thyroid: A Case Report and Review of the Literature. 61
30734898 2019
17
Feasibility and Safety of Endoscopic Thyroidectomy Via a Unilateral Axillobreast Approach for Unilateral Benign Thyroid Tumor in Vietnam. 61
31568258 2019
18
Thyroid lobe size predicts risk of postoperative temporary recurrent laryngeal nerve paralysis. 61
31890892 2019
19
Proteomic analysis of the papillary thyroid microcarcinoma. 61
31606199 2019
20
Significance and management of incidentally diagnosed metastatic papillary thyroid carcinoma in cervical lymph nodes in neck dissection specimens. 61
31390117 2019
21
Thyroid autoimmune diseases and thyroid tumors: Would EBV infection be the link? 61
31120135 2019
22
Transcription Factor Prospero Homeobox 1 (PROX1) as a Potential Angiogenic Regulator of Follicular Thyroid Cancer Dissemination. 61
31717665 2019
23
KLF4 overexpression decreases the viability, invasion and migration of papillary thyroid cancer cells. 61
31602225 2019
24
Potential of epigenetic events in human thyroid cancer. 61
31472323 2019
25
Laparoscopically excised retroperitoneal presacral Schwannoma: atypical pre and postoperative manifestations - case report. 61
31640656 2019
26
Colon Cancer Metastasis Within a NIFTP: A Case Report and Review of the Literature. 61
31625110 2019
27
Genetic Landscape of Somatic Mutations in a Large Cohort of Sporadic Medullary Thyroid Carcinomas Studied by Next-Generation Targeted Sequencing. 61
31605946 2019
28
Acromegaly caused by a somatotroph adenoma in patient with neurofibromatosis type 1. 61
31189769 2019
29
Anaplastic thyroid carcinoma diagnosed after treatment of lenvatinib for papillary thyroid carcinoma. 61
31600721 2019
30
Complications and outcomes associated with unilateral thyroidectomy in dogs with naturally occurring thyroid tumors: 156 cases (2003-2015). 61
31573870 2019
31
Mouse Model of Thyroid Cancer Progression and Dedifferentiation Driven by STRN-ALK Expression and Loss of p53: Evidence for the Existence of Two Types of Poorly Differentiated Carcinoma. 61
31298630 2019
32
TERT Promoter Mutation Spatial Heterogeneity in a Metastatic Follicular Thyroid Carcinoma: Implications for Clinical Work-Up. 61
31154561 2019
33
Using deep convolutional neural networks for multi-classification of thyroid tumor by histopathology: a large-scale pilot study. 61
31700904 2019
34
Prognostic Impact of the Turin Criteria in Poorly Differentiated Thyroid Carcinoma. 61
31098668 2019
35
A Comparative Study of ARHI Imprinted Gene Detection and Fine-Needle Aspiration Cytology in the Differential Diagnosis of Benign and Malignant Thyroid Nodules. 61
31411490 2019
36
[Thyroid tumors in the adult revealed by unilateral laryngeal paralysis]. 61
31471094 2019
37
Ectopic thyroid microfollicular adenoma in the lung: A case report. 61
31464909 2019
38
Targeting PLKs as a therapeutic approach to well-differentiated thyroid cancer. 61
31189135 2019
39
Role of chemokine receptors in thyroid cancer and immunotherapy. 61
31146261 2019
40
Anti-N-methyl-D-aspartate Encephalitis Concomitantly with Tall-cell Variant Papillary Thyroid Carcinoma. 61
31632868 2019
41
Intrapericardial Ectopic Goiter: A Very Unusual Presentation. 61
31447477 2019
42
Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAFV600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair. 61
31097454 2019
43
Synergistic repression of thyroid hyperplasia by cyclin C and Pten. 61
31331961 2019
44
Osteoclastic variant of anaplastic thyroid carcinoma: A case report of rare entity. 61
31169246 2019
45
Thyroid-like follicular carcinoma of the kidney presenting on a 10 year-old prepubertal girl. 61
31063281 2019
46
Clinical utility of genetic diagnosis for sporadic and hereditary medullary thyroid carcinoma. 61
31053251 2019
47
Clinicopathological Significance of Overall Frequency of Allelic Loss (OFAL) in Lesions Derived from Thyroid Follicular Cell. 61
30747408 2019
48
Long noncoding RNA RP11-547D24.1 regulates proliferation and migration in papillary thyroid carcinoma: Identification and validation of a novel long noncoding RNA through integrated analysis of TCGA database. 61
31044550 2019
49
Galectin-3 Targeting in Thyroid Orthotopic Tumors Opens New Ways to Characterize Thyroid Cancer. 61
30361380 2019
50
Dysbiosis of the gut microbiome is associated with thyroid cancer and thyroid nodules and correlated with clinical index of thyroid function. 61
30584647 2019

Variations for Thyroid Tumor

ClinVar genetic disease variations for Thyroid Tumor:

6 (show all 41) ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 KRAS NM_033360.4(KRAS):c.34G>C (p.Gly12Arg)SNV Pathogenic 12579 rs121913530 12:25398285-25398285 12:25245351-25245351
2 KRAS NM_033360.4(KRAS):c.38G>A (p.Gly13Asp)SNV Pathogenic 12580 rs112445441 12:25398281-25398281 12:25245347-25245347
3 KRAS NM_004985.5(KRAS):c.35G>A (p.Gly12Asp)SNV Pathogenic 12582 rs121913529 12:25398284-25398284 12:25245350-25245350
4 KRAS NM_004985.5(KRAS):c.35G>T (p.Gly12Val)SNV Pathogenic 12583 rs121913529 12:25398284-25398284 12:25245350-25245350
5 KRAS NM_033360.4(KRAS):c.34G>A (p.Gly12Ser)SNV Pathogenic 12584 rs121913530 12:25398285-25398285 12:25245351-25245351
6 KRAS NM_033360.4(KRAS):c.37G>C (p.Gly13Arg)SNV Pathogenic 12593 rs121913535 12:25398282-25398282 12:25245348-25245348
7 HRAS NM_005343.4(HRAS):c.35G>T (p.Gly12Val)SNV Pathogenic 12600 rs104894230 11:534288-534288 11:534288-534288
8 HRAS NM_005343.4(HRAS):c.34G>A (p.Gly12Ser)SNV Pathogenic 12602 rs104894229 11:534289-534289 11:534289-534289
9 HRAS NM_005343.4(HRAS):c.35G>C (p.Gly12Ala)SNV Pathogenic 12603 rs104894230 11:534288-534288 11:534288-534288
10 HRAS NM_005343.4(HRAS):c.37G>T (p.Gly13Cys)SNV Pathogenic 12606 rs104894228 11:534286-534286 11:534286-534286
11 HRAS NM_005343.4(HRAS):c.34G>T (p.Gly12Cys)SNV Pathogenic 12613 rs104894229 11:534289-534289 11:534289-534289
12 RET NM_020975.6(RET):c.1902C>G (p.Cys634Trp)SNV Pathogenic 13918 rs77709286 10:43609950-43609950 10:43114502-43114502
13 RET NM_020975.6(RET):c.2753T>C (p.Met918Thr)SNV Pathogenic 13919 rs74799832 10:43617416-43617416 10:43121968-43121968
14 BRAF NM_004333.6(BRAF):c.1801A>G (p.Lys601Glu)SNV Pathogenic 13966 rs121913364 7:140453134-140453134 7:140753334-140753334
15 KRAS NM_033360.4(KRAS):c.181C>A (p.Gln61Lys)SNV Pathogenic 177777 rs121913238 12:25380277-25380277 12:25227343-25227343
16 KRAS NM_033360.4(KRAS):c.182A>G (p.Gln61Arg)SNV Pathogenic 45115 rs121913240 12:25380276-25380276 12:25227342-25227342
17 KRAS NM_033360.4(KRAS):c.182A>T (p.Gln61Leu)SNV Pathogenic 45116 rs121913240 12:25380276-25380276 12:25227342-25227342
18 NRAS NM_002524.5(NRAS):c.182A>C (p.Gln61Pro)SNV Pathogenic 280409 rs11554290 1:115256529-115256529 1:114713908-114713908
19 NRAS NM_002524.5(NRAS):c.183A>T (p.Gln61His)SNV Pathogenic 373003 rs121913255 1:115256528-115256528 1:114713907-114713907
20 KRAS NM_033360.4(KRAS):c.437C>T (p.Ala146Val)SNV Pathogenic 375962 rs1057519725 12:25378561-25378561 12:25225627-25225627
21 KRAS NM_033360.4(KRAS):c.37G>A (p.Gly13Ser)SNV Pathogenic 375968 rs121913535 12:25398282-25398282 12:25245348-25245348
22 KRAS NM_033360.4(KRAS):c.182A>C (p.Gln61Pro)SNV Pathogenic/Likely pathogenic 375966 rs121913240 12:25380276-25380276 12:25227342-25227342
23 HRAS NM_005343.4(HRAS):c.37G>C (p.Gly13Arg)SNV Pathogenic/Likely pathogenic 35554 rs104894228 11:534286-534286 11:534286-534286
24 BRAF NM_004333.6(BRAF):c.1802A>C (p.Lys601Thr)SNV Pathogenic/Likely pathogenic 44818 rs397507484 7:140453133-140453133 7:140753333-140753333
25 NRAS NM_002524.5(NRAS):c.182A>T (p.Gln61Leu)SNV Pathogenic/Likely pathogenic 375874 rs11554290 1:115256529-115256529 1:114713908-114713908
26 HRAS , LRRC56 NM_005343.4(HRAS):c.34G>C (p.Gly12Arg)SNV Pathogenic/Likely pathogenic 375961 rs104894229 11:534289-534289 11:534289-534289
27 KRAS NM_033360.4(KRAS):c.183A>T (p.Gln61His)SNV Pathogenic/Likely pathogenic 45117 rs17851045 12:25380275-25380275 12:25227341-25227341
28 KRAS NM_033360.4(KRAS):c.34G>T (p.Gly12Cys)SNV Pathogenic/Likely pathogenic 12578 rs121913530 12:25398285-25398285 12:25245351-25245351
29 PIK3CA NM_006218.4(PIK3CA):c.353G>A (p.Gly118Asp)SNV Pathogenic/Likely pathogenic 156446 rs587777790 3:178917478-178917478 3:179199690-179199690
30 PIK3CA NM_006218.4(PIK3CA):c.3129G>A (p.Met1043Ile)SNV Pathogenic/Likely pathogenic 179173 rs121913283 3:178952074-178952074 3:179234286-179234286
31 HRAS NM_005343.4(HRAS):c.182A>G (p.Gln61Arg)SNV Likely pathogenic 160364 rs121913233 11:533874-533874 11:533874-533874
32 KRAS NM_033360.4(KRAS):c.38G>T (p.Gly13Val)SNV drug response 45124 rs112445441 12:25398281-25398281 12:25245347-25245347
33 HRAS , LRRC56 NM_005343.4(HRAS):c.182A>T (p.Gln61Leu)SNV Likely pathogenic 376033 rs121913233 11:533874-533874 11:533874-533874
34 BRAF NM_004333.6(BRAF):c.1803A>C (p.Lys601Asn)SNV Likely pathogenic 376286 rs121913365 7:140453132-140453132 7:140753332-140753332
35 HRAS NM_005343.4(HRAS):c.183G>T (p.Gln61His)SNV Likely pathogenic 376318 rs121913496 11:533873-533873 11:533873-533873
36 HRAS , LRRC56 NM_005343.4(HRAS):c.182A>C (p.Gln61Pro)SNV Likely pathogenic 376322 rs121913233 11:533874-533874 11:533874-533874
37 HRAS , LRRC56 NM_005343.4(HRAS):c.181C>G (p.Gln61Glu)SNV Likely pathogenic 376444 rs28933406 11:533875-533875 11:533875-533875
38 PIK3CA NM_006218.4(PIK3CA):c.3127A>G (p.Met1043Val)SNV Likely pathogenic 376485 rs1057519936 3:178952072-178952072 3:179234284-179234284
39 PIK3CA NM_006218.4(PIK3CA):c.3128T>C (p.Met1043Thr)SNV Likely pathogenic 376486 rs1057519937 3:178952073-178952073 3:179234285-179234285
40 PIK3CA NM_006218.4(PIK3CA):c.3127A>T (p.Met1043Leu)SNV Likely pathogenic 376487 rs1057519936 3:178952072-178952072 3:179234284-179234284
41 AKT1 NM_005163.2(AKT1):c.49G>A (p.Glu17Lys)SNV Uncertain significance 13983 rs121434592 14:105246551-105246551 14:104780214-104780214

Expression for Thyroid Tumor

Search GEO for disease gene expression data for Thyroid Tumor.

Pathways for Thyroid Tumor

Pathways related to Thyroid Tumor according to GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.15 TP53 RET PTEN PRKAR1A PIK3CA NRAS
2
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13.95 TP53 TIMP3 PTEN PRKAR1A NRAS MMP2
3
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13.93 TP53 TIMP3 PTEN PRKAR1A NRAS KRAS
4
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13.81 TP53 TIMP3 PRKAR1A NRAS MMP2 KRAS
5
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13.64 TP53 TIMP3 PIK3CA NRAS KRAS HRAS
6
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13.61 RET PIK3CA NRAS MMP2 KRAS HRAS
7
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13.52 PTEN PRKAR1A PIK3CA NRAS MMP2 KRAS
8
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13.48 TP53 RET PIK3CA NRAS MMP2 KRAS
9
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13.43 TIMP3 PTEN PRKAR1A NRAS KRAS HRAS
10
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13.42 TP53 TIMP3 PRKAR1A PIK3CA NRAS KRAS
11
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13.4 TIMP3 PTEN PRKAR1A NRAS KRAS HRAS
12
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13.38 TIMP3 PRKAR1A NRAS KRAS HRAS FGFR2
13
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13.32 TP53 PTEN PRKAR1A NRAS KRAS HRAS
14
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13.22 TP53 PIK3CA NRAS KRAS HRAS BRAF
15
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13.18 TP53 TIMP3 PTEN NRAS KRAS HRAS
16
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13.15 TIMP3 PRKAR1A NRAS KRAS HRAS FGFR2
17
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13.1 TP53 TERT PTEN PIK3CA NRAS KRAS
18
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13.06 TP53 PTEN PIK3CA NRAS KRAS HRAS
19
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13.04 PTEN PRKAR1A PIK3CA NRAS KRAS HRAS
20
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13.03 PTEN PRKAR1A NRAS KRAS HRAS BRAF
21
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13.01 TPO TG NRAS KRAS HRAS BRAF
22
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13.01 PTEN PIK3CA NRAS KRAS HRAS BRAF
23
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12.99 PRKAR1A PIK3CA NRAS KRAS HRAS BRAF
24
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12.97 PTEN PRKAR1A PIK3CA NRAS KRAS HRAS
25
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12.94 PIK3CA NRAS KRAS HRAS BRAF
26
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12.92 PIK3CA NRAS KRAS HRAS BRAF
27
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12.9 TP53 PIK3CA NRAS KRAS HRAS
28
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12.9 PRKAR1A NRAS KRAS HRAS BRAF
29 12.89 TP53 NRAS KRAS HRAS FGFR2 BRAF
30
Show member pathways
12.89 TP53 RET PTEN PIK3CA NRAS KRAS
31
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12.87 PTEN PIK3CA KRAS HRAS BRAF
32
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12.86 PIK3CA NRAS KRAS HRAS FGFR2 BRAF
33
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12.85 TP53 PTEN PIK3CA NRAS KRAS HRAS
34
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12.83 TP53 PTEN PIK3CA NRAS KRAS HRAS
35
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12.78 PIK3CA NRAS MMP2 KRAS HRAS
36
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12.78 PRKAR1A NRAS KRAS HRAS BRAF
37
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12.77 TP53 NRAS KRAS HRAS BRAF
38 12.76 PIK3CA NRAS KRAS HRAS FGFR2 BRAF
39
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12.75 PIK3CA NRAS MMP2 KRAS HRAS
40
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12.72 TP53 PIK3CA NRAS MMP2 KRAS HRAS
41
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12.71 PTEN PIK3CA NRAS KRAS HRAS
42
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12.7 PTEN PIK3CA NRAS KRAS HRAS
43
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12.69 PIK3CA NRAS KRAS HRAS FGFR2 BRAF
44
Show member pathways
12.69 TP53 TERT PTEN PIK3CA NRAS KRAS
45
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12.67 TP53 PTEN PIK3CA NRAS KRAS HRAS
46 12.65 TP53 TIMP3 PTEN PIK3CA NRAS KRAS
47
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12.64 TP53 PIK3CA NRAS KRAS HRAS BRAF
48
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12.63 PIK3CA NRAS KRAS HRAS BRAF
49
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12.61 TNS3 PIK3CA NRAS KRAS HRAS
50
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12.6 PTEN PIK3CA NRAS KRAS HRAS

GO Terms for Thyroid Tumor

Cellular components related to Thyroid Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.47 TPO TERT RET PTEN PRKAR1A PIK3CA
2 collagen-containing extracellular matrix GO:0062023 9.35 TIMP3 MMP2 LGALS3 FGFR2 ABI3BP

Biological processes related to Thyroid Tumor according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.81 PTEN PIK3CA MMP2 FGFR2
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.78 PTEN HRAS FGFR2 BRAF
3 positive regulation of gene expression GO:0010628 9.73 TP53 RET PTEN KRAS HRAS BRAF
4 animal organ morphogenesis GO:0009887 9.71 THRB HRAS FGFR2 BRAF
5 regulation of protein stability GO:0031647 9.67 TERT PTEN KRAS
6 hormone biosynthetic process GO:0042446 9.52 TPO TG
7 thyroid gland development GO:0030878 9.5 THRB TG BRAF
8 regulation of axon regeneration GO:0048679 9.46 PTEN BRAF
9 Ras protein signal transduction GO:0007265 9.46 TP53 NRAS KRAS HRAS
10 response to isolation stress GO:0035900 9.43 KRAS HRAS
11 positive regulation of TRAIL-activated apoptotic signaling pathway GO:1903984 9.37 TIMP3 PTEN
12 negative regulation of neuron apoptotic process GO:0043524 9.35 TERT PIK3CA KRAS HRAS BRAF
13 MAPK cascade GO:0000165 9.1 RET NRAS KRAS HRAS FGFR2 BRAF

Molecular functions related to Thyroid Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 TP53 TNS3 TIMP3 THRB TERT RET
2 GDP binding GO:0019003 9.33 NRAS KRAS HRAS
3 nucleotide binding GO:0000166 9.1 RET NRAS KRAS HRAS FGFR2 BRAF

Sources for Thyroid Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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