MCID: THY032
MIFTS: 56

Thyroiditis

Categories: Endocrine diseases, Infectious diseases, Respiratory diseases

Aliases & Classifications for Thyroiditis

MalaCards integrated aliases for Thyroiditis:

Name: Thyroiditis 12 54 6 44 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:7166
ICD9CM 34 245
MeSH 44 D013966
NCIt 50 C26894
SNOMED-CT 67 154664009
ICD10 32 E06 E06.9
UMLS 70 C0040147

Summaries for Thyroiditis

MalaCards based summary : Thyroiditis is related to subacute thyroiditis and suppurative thyroiditis. An important gene associated with Thyroiditis is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Dexmedetomidine and Nitroprusside have been mentioned in the context of this disorder. Affiliated tissues include thyroid, lymph node and eye, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Related Diseases for Thyroiditis

Diseases in the Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1291)
# Related Disease Score Top Affiliating Genes
1 subacute thyroiditis 32.6 TSHR TPO TNF TG SERPINA7 IL6
2 suppurative thyroiditis 32.6 TSHR TPO TG CALCA
3 subacute lymphocytic thyroiditis 32.6 TSHR TPO TG IL2
4 acute thyroiditis 32.2 TPO TG SERPINA7 CALCA
5 hyperthyroidism 32.0 TSHR TPO TG SERPINA7 CTLA4 CALCA
6 endocrine exophthalmos 32.0 TG IL6
7 thyrotoxic exophthalmos 31.9 TG IL6
8 thyroid carcinoma 31.7 TSHR TPO TG CALCA
9 myxedema 31.7 TSHR TPO TG SERPINA7 CTLA4
10 atrophic gastritis 31.6 TNF IL6 IL10
11 goiter 31.5 TSHR TPO TG SERPINA7 CALCA
12 graves disease 1 31.3 TSHR TPO TG SERPINA7 CALCA
13 papillary carcinoma 31.3 TSHR TPO TG CALCA
14 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 31.1 IL4 IL2 IL10 FOXP3 CTLA4 AIRE
15 hashimoto thyroiditis 31.1 TSHR TPO TG SERPINA7 PTPN22 PRSS3
16 exophthalmos 31.0 TSHR TPO TG
17 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.9 TSHR TPO TG PTPN22 IL10 IFNG
18 differentiated thyroid carcinoma 30.9 TSHR TPO TG
19 hypoparathyroidism 30.9 TPO CTLA4 CALCA AIRE
20 nodular goiter 30.8 TSHR TPO TG IL6 CTLA4 CALCA
21 multinodular goiter 30.8 TSHR TPO TG IL10 CALCA
22 follicular adenoma 30.8 TSHR TPO TG CALCA
23 thyroid gland disease 30.8 TSHR TSHB TPO TG SERPINA7 IL6
24 hypothyroidism 30.7 TSHR TSHB TPO TNF TG SERPINA7
25 pernicious anemia 30.7 TPO TG PTPN22 AIRE
26 vitiligo-associated multiple autoimmune disease susceptibility 1 30.7 TPO TNF PTPN22 IL2 CTLA4 AIRE
27 papillary thyroid microcarcinoma 30.7 TSHR TG CALCA
28 graves' disease 30.6 TSHR TPO TG SERPINA7 PTPN22 IL4
29 thymoma 30.6 IL2 FOXP3 CTLA4 AIRE
30 urticaria 30.6 TNF IL6 IL4 IL10
31 lupus erythematosus 30.6 TNF PTPN22 IL10 IFNG FASLG CTLA4
32 postsurgical hypothyroidism 30.5 TPO TG
33 chronic urticaria 30.5 TPO TNF TG IL6 IL4
34 mechanical strabismus 30.5 TPO TG
35 thyroid gland cancer 30.5 TSHR TPO TG CALCA
36 purpura 30.5 TNF IL6 IL4 IL10 IFNG
37 turner syndrome 30.5 TPO TG SERPINA7 PTPN22
38 thyroid gland anaplastic carcinoma 30.5 TSHR TPO TG CALCA
39 pericarditis 30.4 TNF IL6 IFNG
40 thyroid gland follicular carcinoma 30.4 TSHR TPO TG CALCA
41 plummer's disease 30.4 TSHR TPO TG SERPINA7
42 lymphadenitis 30.4 TNF IL10 IFNG FASLG
43 cholangitis 30.4 TNF IL6 IL2 IL10 CTLA4
44 celiac disease 1 30.3 TPO TNF TG PTPN22 PRSS3 IL6
45 alopecia 30.3 TNF IL4 IL2 IFNG CTLA4 AIRE
46 pneumocystosis 30.3 TNF IL6 IL2
47 typhoid fever 30.3 TNF IL6 IFNG
48 hyperthyroxinemia 30.3 TSHR TPO SERPINA7
49 mixed connective tissue disease 30.3 TNF IL6 IL10 IFNG
50 bacterial infectious disease 30.3 TNF IL6 IL10 IFNG

Comorbidity relations with Thyroiditis via Phenotypic Disease Network (PDN):


Hypothyroidism

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to Thyroiditis

Symptoms & Phenotypes for Thyroiditis

MGI Mouse Phenotypes related to Thyroiditis:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.37 AIRE CTLA4 FASLG FOXP3 IFNG IL10
2 hematopoietic system MP:0005397 10.37 AIRE CTLA4 FASLG FOXP3 IFNG IL10
3 immune system MP:0005387 10.33 AIRE CTLA4 FASLG FOXP3 IFNG IL10
4 growth/size/body region MP:0005378 10.32 AIRE FOXP3 IFNG IL10 IL2 IL4
5 homeostasis/metabolism MP:0005376 10.32 AIRE CTLA4 FASLG FOXP3 IFNG IL10
6 digestive/alimentary MP:0005381 10.31 AIRE CTLA4 FASLG FOXP3 IFNG IL10
7 liver/biliary system MP:0005370 10.14 AIRE CTLA4 FASLG FOXP3 IFNG IL10
8 integument MP:0010771 10.09 CTLA4 FASLG FOXP3 IFNG IL10 IL4
9 reproductive system MP:0005389 10.03 AIRE FASLG FOXP3 IFNG IL10 IL2
10 neoplasm MP:0002006 9.97 AIRE FASLG IFNG IL10 IL2 IL6
11 respiratory system MP:0005388 9.9 AIRE CTLA4 FASLG FOXP3 IFNG IL10
12 no phenotypic analysis MP:0003012 9.87 AIRE FOXP3 IFNG IL10 IL2 IL4
13 skeleton MP:0005390 9.65 CTLA4 FASLG IFNG IL10 IL4 IL6
14 vision/eye MP:0005391 9.36 AIRE FASLG FOXP3 IFNG IL10 IL2

Drugs & Therapeutics for Thyroiditis

Drugs for Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 456)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
2
Nitroprusside Approved, Investigational Phase 4 15078-28-1 11963622
3
Nitric Oxide Approved Phase 4 10102-43-9 145068
4
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
5
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
6
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
7
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
8
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
9
Polyestradiol phosphate Approved Phase 4 28014-46-2
10
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
11
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
12
Testosterone Approved, Investigational Phase 4 58-22-0 6013
13
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
14
Dinoprost tromethamine Approved, Vet_approved Phase 4 38562-01-5 5282415
15
Dinoprost Approved, Investigational Phase 4 551-11-1 5283078
16
Sodium citrate Approved, Investigational Phase 4 68-04-2
17
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
18
Acetylcysteine Approved, Investigational Phase 4 616-91-1 12035
19
Sertraline Approved Phase 4 79617-96-2 68617
20
Morphine Approved, Investigational Phase 4 57-27-2 5288826
21
tannic acid Approved Phase 4 1401-55-4
22
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
23
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
24
Lactulose Approved Phase 4 4618-18-2 11333
25
Desflurane Approved Phase 4 57041-67-5 42113
26
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
27
Phenylpropanolamine Approved, Vet_approved, Withdrawn Phase 4 14838-15-4 26934
28
Acetaminophen Approved Phase 4 103-90-2 1983
29
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
30
Codeine Approved, Illicit Phase 4 76-57-3 5284371
31
Metformin Approved Phase 4 657-24-9 4091 14219
32
Dopamine Approved Phase 4 62-31-7, 51-61-6 681
33
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
34
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
35
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
36
Thiamine Approved, Investigational, Nutraceutical, Vet_approved Phase 4 70-16-6, 59-43-8 1130
37 Hypnotics and Sedatives Phase 4
38 Adrenergic alpha-Agonists Phase 4
39 Adrenergic Agonists Phase 4
40 Anesthetics, General Phase 4
41 Anesthetics, Inhalation Phase 4
42 Anesthetics, Intravenous Phase 4
43 Platelet Aggregation Inhibitors Phase 4
44 Viscosupplements Phase 4
45 Adjuvants, Immunologic Phase 4
46 Proxymetacaine Phase 4
47 Vasodilator Agents Phase 4
48 Triamcinolone diacetate Phase 4
49 Triamcinolone hexacetonide Phase 4
50 triamcinolone acetonide Phase 4

Interventional clinical trials:

(show top 50) (show all 1094)
# Name Status NCT ID Phase Drugs
1 Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction Unknown status NCT02512978 Phase 4 Levothyroxine
2 Efficacy and Safety of Levothyroxine (L-T4) Replacement on Exercise Capability in Chronic Systolic Heart Failure Patients With Subclinical Hypothyroidism: A 24-week, Multi-center, Open Label, Randomized, Parallel Group Trial Unknown status NCT03096613 Phase 4 Levothyroxine
3 Open-Label, Multi-Center, Randomized, Active-Controlled, Phase 4 Study of rAd-p53 Gene Mono-Therapy, With Concurrent Radioactive Iodine , or Combination With Surgery in Subjects With Advanced Malignant Thyroid Tumors Unknown status NCT00902122 Phase 4 rAd-p53 gene;p53 gene therapy
4 Total Thyroidectomy With Harmonic Scalpel® Versus Standard Surgery. Open Multicentric Randomized Controlled Trial Unknown status NCT00385983 Phase 4
5 Rituximab (RTX) Therapy in Steroid Resistant Patients or Patients Relapsing After Intravenous Steroids With Active TAO Unknown status NCT02378298 Phase 4 Rituximab;Iv Methylprednisolone;peroral methylprednisolone and Methotrexate
6 The Use of Lu177 in the Treatment of Progressive and Unresectable Metastatic Medullary Thyroid Cancer Unknown status NCT01915485 Phase 4
7 Phase IV Study of Hyaluronic Acid Gels for Upper Lid Retraction in Active Stage Thyroid Eye Disease Unknown status NCT01738243 Phase 4 Hyaluronic Acid Gel injection;Saline injection
8 Effect of Propofol on Remifentanil-induced Postoperative Hyperalgesia in Patients Undergoing Thyroid Surgery Unknown status NCT01189721 Phase 4 propofol, sevoflurane
9 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Unknown status NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
10 Efficacy of Intravenous Lidocaine in the Operative Management of Thyroid Surgery With Intraoperative Nerve Monitoring Unknown status NCT02479789 Phase 4 Lidocaine;Placebo
11 Cardiopulmonary Capacity In Different Quartiles Ranges Of Reference For Serum Thyroid Stimulating Hormone (TSH): Sectional Evaluation And Effect Of The Use Of Methimazole In Elderly Population Unknown status NCT01849861 Phase 4 Methimazole
12 Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General anesthesia---a Randomized Control Double-Blind Clinical Trial Unknown status NCT02613806 Phase 4 Dexmeditomidine;normal saline
13 Does Sodium Nitroprusside Infusion Affect Thyroidal Function in Patients Undergoing Coronary Artery Bypass Grafting, a Prospective Randomized Clinical Trial. Unknown status NCT00636584 Phase 4 sodium nitroprusside;placebo
14 Effects of Thyroid Hormone Treatment on Mitochondrial Function, Ectopic Fat Accumulation, Insulin Sensitivity and Brown Adipose Tissue in Type 2 Diabetes Mellitus Unknown status NCT01379170 Phase 4 Euthyrox (levothyroxine)
15 Effect of the Administration of Etoricoxib on Postoperative Pain and Quality of Recovery in Patients Undergoing Thyroid Surgery Unknown status NCT00935116 Phase 4 etoricoxib
16 Efficacy of Dexmedetomidine for Cough Suppression During Anesthetic Emergence in Patients Undergoing Thyroid Surgery: A Randomized, Double Blinded, Controlled Trial Unknown status NCT03312413 Phase 4 Dexmedetomidine Hydrochloride;Normal Saline;Dexmedetomidine Hydrochloride;Dexmedetomidine Hydrochloride
17 Efficiency and Safety Study of Short-term Prednisone to Treat Moderate and Severe Subacute Thyroiditis Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
18 L-selenomethionine Supplementation in Children and Adolescents With Autoimmune Thyroiditis: a Randomized Blind Placebo-controlled Clinical Trial Completed NCT02644707 Phase 4
19 Is it Possible to Increase Quality of Life, Using Recombinant TSH Instead of Withdrawal of Thyroid Hormone Treatment, Before Iodine Uptake in Patients With Thyroid Cancer? Completed NCT00604318 Phase 4 rhTSH
20 Prevention Relapse of Graves' Disease by Treatment With Intrathyroid Injection of Dexamethasone Completed NCT00917241 Phase 4 MMI combined with IID;MMI
21 Is the Routine Pressure Dressing After Thyroidectomy Necessary? A Prospective Randomized Controlled Study Completed NCT00400465 Phase 4
22 A Double-masked, Methylprednisolone-control, Efficacy and Safety Study of 99Tc-MDP for Thyroid Associated Ophthalmopathy. Completed NCT03948191 Phase 4 Methylprednisolone;99Tc-MDP(99Technetium-Methylenediphosphonate Injection)
23 Effect of Thyroid Hormone Replacement on Fatigability in Untreated Older Adults With Subclinical Hypothyroidism Completed NCT02500342 Phase 4 Levothyroxine;Placebo
24 Novel Biomarkers and Skeletal Outcomes Associated With Subclinical Thyroid Dysfunction: a Prospective Evaluation and Impact of Treatment Completed NCT02491008 Phase 4 Levothyroxine;Placebo
25 Diagnostic Accuracy Study of Indocyanine Green for Parathyroid Perfusion Assessment Completed NCT03969108 Phase 4 Indocyanine Green
26 Impact of Thyroid Hormone Replacement on Cardiac Function: a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism Completed NCT02832960 Phase 4 Levothyroxine;Placebo
27 Impact of Thyroid Hormone Replacement on Progression of Atherosclerosis : a Randomized Placebo-Controlled Trial in Older Adults With Subclinical Hypothyroidism. Completed NCT02832934 Phase 4 Levothyroxine;Placebo
28 Treatment of Upper Eyelid Retraction Related to Thyroid-associated Ophthalmopathy Using Subconjunctival Triamcinolone Injections Completed NCT01599273 Phase 4 subconjunctival triamcinolone injection
29 Dose-dependent Effect of Fentanyl on Cough Attenuation During Emergence From General Anaesthesia Completed NCT01308320 Phase 4 fentanyl citrate;saline
30 Multicentric Randomized Controlled Study of Percutaneous Laser Ablation Versus Follow Up in Benign Thyroid Nodules. Long Term Results Completed NCT00858104 Phase 4
31 A Dosimetry Study of Radioiodine (131-I) Uptake Following the Administration of Thyrogen and Hypothyroid States During Thyroid Hormone Withdrawal Completed NCT00001730 Phase 4 Thyrogen
32 Evaluation of the Effects of N-acetylcysteine on Thyroid Hormone Levels in the Low T3 Syndrome Completed NCT01501110 Phase 4 N-acetylcysteine
33 The Effect of Metformin Treatment on Thyroid Hormone Metabolism in Euthyroid Patients With Type 2 Diabetes Mellitus Completed NCT00463502 Phase 4 Metformin
34 A Comparison of Transdermal vs. Oral Estrogen Replacement Therapy on Androgen Levels and Thyroid Function in Naturally Menopausal Women Completed NCT00224094 Phase 4 Premarin® (oral) vs. Alora® (transdermal)
35 Thyroid Axis in Major Depression Completed NCT00208702 Phase 4 Triiodothyronine;Sertraline
36 Thyroid Hormone Replacement for Subclinical Hypothyroidism (TRUST) - Subanalysis on Subclinical Hypothyroidism and Depression Completed NCT01853579 Phase 4 Levothyroxine;Placebo
37 The Effect of Thyroid Hormone Therapy on Muscle Mass and Function in Older Adults With Subclinical Hypothyroidism - a Substudy of TRUST and IEMO Trials Completed NCT04354896 Phase 4 Levothyroxin;Placebo
38 Multi-modal Effects of Thyroid Hormone Replacement for Untreated Older Adults With Subclinical Hypothyroidism; a Randomised Placebo-controlled Trial Completed NCT01660126 Phase 4 Levothyroxine;Placebo
39 Prostaglandin F2-alpha Eye Drops (Bimatoprost) in Thyroid Eye Disease: a Randomised Controlled Double Blind Crossover Trial Completed NCT02059655 Phase 4 Bimatoprost;Eye drop solution
40 Anti-adhesive Effect and Safety of "Thermo-sensitive Adhesion Barrier (MEDICLORE)" by Using Double-blind Test in Thyroid Surgery Completed NCT03293186 Phase 4
41 Celecoxib for Reducing Morphine Requirement After Thyroid Surgery: A Randomized Controlled Trial Completed NCT00520338 Phase 4 celecoxib
42 Yield of Diagnostic Tests and Management of Crofelemer for Chronic Idiopathic Diarrhea In Non-HIV Patients: A Pilot Study Recruiting NCT03898856 Phase 4 Crofelemer
43 The Impact of Preoperative Oral Dexamethasone Supplementation on the Biochemical Parameters and Results of Surgical Treatment in Patients With Nontoxic Multinodular Goiter Undergoing Total Thyroidectomy. Recruiting NCT04412694 Phase 4 Dexamethasone oral tablet 8mg (Dexamethasone Krka tablets(8mg), Warsaw, Poland).;Placebo oral sweetener (Clio tablets, sweetener with a dispenser, Instantina GES, Vienna, Austria).
44 An Investigation of Optimal Anesthesia for Morbidly Obese Patients Undergoing Bariatric Surgery: A Randomized Controlled Trial Recruiting NCT04395248 Phase 4 Type of volatile anesthetics and M-Entropy guidance of anesthesia depth
45 Using A Novel Classification System in Intravenous Glucocorticoids Therapy of TAO: A Multi-central, Randomized, Open, Superior Trial Recruiting NCT03107078 Phase 4 Glucocorticoids
46 Intravenous Or Topical Lidocaine And Neuromonitoring in Thyroid Surgery (IOLANT Study) Recruiting NCT04574947 Phase 4 Intravenous lidocaine;Intravenous placebo
47 Randomized Controlled Trial of Preoperative Steroids in Autoimmune Thyroid Disease Recruiting NCT04542278 Phase 4 Prednisone
48 A Prospective, Multicenter Observational Study to Evaluate Thyroid Function of Pediatric Subjects From Birth to 3 Years Exposed to ISOVUE® (Iopamidol Injection) Recruiting NCT03779906 Phase 4 Isovue
49 Prospective Single Arm Post Marketing Phase IV Study to Assess the Safety and Efficacy of Lenvatinib in Subjects With Locally Recurrent or Metastatic, Progressive, Radioiodine Refractory Differentiated Thyroid Cancer Active, not recruiting NCT03573960 Phase 4 Lenvatinib
50 A Randomized, Double-blind Study To Evaluate the Efficacy and Safety of Cabozantinib (XL184) at 60 mg/Day Compared to a 140 mg/Day in Progressive, Metastatic Medullary Thyroid Cancer Patients Active, not recruiting NCT01896479 Phase 4 Cabozantinib (XL184) 140 mg;Cabozantinib (XL184) 60 mg;Placebo tablet;Placebo capsule

Search NIH Clinical Center for Thyroiditis

Cochrane evidence based reviews: thyroiditis

Genetic Tests for Thyroiditis

Anatomical Context for Thyroiditis

MalaCards organs/tissues related to Thyroiditis:

40
Thyroid, Lymph Node, Eye, T Cells, Pituitary, Breast, Endothelial

Publications for Thyroiditis

Articles related to Thyroiditis:

(show top 50) (show all 14528)
# Title Authors PMID Year
1
Hepatitis C and interferon induced thyroiditis. 54 61
20022216 2010
2
Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases? 54 61
20464711 2010
3
Painless thyroiditis complicated by acromegaly. 61 54
20075583 2010
4
Dynamic changes of IgG subtypes of thyroid peroxidase antibody in patients with postpartum thyroiditis. 54 61
19829002 2010
5
Interferon induced thyroiditis. 61 54
19942147 2009
6
Expression of CD152 (CTLA-4) in children with autoimmune thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene. 61 54
20134044 2009
7
49A/G and CT60 polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4 gene associated with autoimmune thyroid disease. 61 54
19559744 2009
8
Cytomorphologic study of Hashimoto's thyroiditis and its serologic correlation: a study of 150 cases. 61 54
19798877 2009
9
Different phenotypy in three siblings with homocystinuria. 54 61
19430269 2009
10
Silent thyroiditis, isolated corticotropin deficiency, and alopecia universalis in a patient with ulcerative colitis and elevated levels of plasma factor VIII: an unusual case of autoimmune polyglandular syndrome type 3. 61 54
19289325 2009
11
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma. 54 61
19606248 2009
12
[Thyroid disorders during pregnancy]. 61 54
19142837 2009
13
Evaluation of the role of ultrasonography in diagnosis of autoimmune thyroiditis in goitrous children. 61 54
18451445 2008
14
Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodies. 61 54
18029466 2008
15
A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes. 54 61
18489063 2008
16
Interferon alpha treatment and thyroid dysfunction. 54 61
17983936 2007
17
Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis. 54 61
17887926 2007
18
Obstetric management of thyroid disease. 61 54
17868484 2007
19
[Epidemiologic study of autoimmune thyroid disease in south Tunisia]. 54 61
17194970 2006
20
By-stander activation in autoimmune thyroiditis: studies on experimental autoimmune thyroiditis in the GFP+ fluorescent mouse. 54 61
16916620 2006
21
Circulating level of the platelet-derived CXC chemokine platelet factor 4 in chronic urticaria patients with or without coexistent euthyroid Hashimoto's thyroiditis. 54 61
16891214 2006
22
Clinical and laboratory aspects of thyroid autoantibodies. 54 61
16704751 2006
23
Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease. 54 61
16498048 2006
24
Thyroid hormone increases mannan-binding lectin levels. 54 61
16260422 2005
25
Graves' hyperthyroidism showing transient hypothyroidism during interferon therapy for chronic hepatitis type C. 54 61
16006723 2005
26
Thyroid disorders associated with pregnancy: etiology, diagnosis, and management. 61 54
15649099 2005
27
Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice. 61 54
15320899 2004
28
Inducing Graves' ophthalmopathy. 54 61
15164995 2004
29
[Clinical implications of occurrence of antithyroid antibodies in pregnant women and in the postpartum period]. 54 61
15789919 2004
30
[Subclinical thyroid disease--should we treat, should we screen for it?]. 61 54
15114790 2003
31
Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b. 54 61
14611699 2003
32
Consequences of autoimmune thyroiditis before, during and after pregnancy. 61 54
14605606 2003
33
Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen. 61 54
12780686 2003
34
Interferon-alpha and autoimmune thyroid disease. 54 61
12930598 2003
35
Induction of murine thyroiditis by a non dominant E(k)-restricted peptide of human thyroglobulin. 61 54
12667218 2003
36
Extrapancreatic autoimmune manifestations in type 1 diabetes patients and their first-degree relatives: a multicenter study. 61 54
12663603 2003
37
[Hypothyroidism: clinical and economical implications in a health area]. 54 61
12756897 2003
38
[Interferon-alpha and auto-immunity]. 61 54
12481406 2002
39
Temporal relationship between the appearance of thyroid autoantibodies and development of destructive thyroiditis in patients undergoing treatment with two different type-1 interferons for HCV-related chronic hepatitis: a prospective study. 54 61
12150338 2002
40
[Anti thyroglobulin antibodies in the follow up of patients with differentiated thyroid cancer: residual or relapsing disease markers?]. 54 61
11974529 2002
41
Expression of CD40 and apoptosis related molecules in autoimmune thyroid diseases. 54 61
11675676 2001
42
Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. 54 61
11588143 2001
43
Pregnancy and murine thyroiditis: thyroglobulin immunization leads to fetal loss in specific allogeneic pregnancies. 54 61
11159855 2001
44
Non-MHC driven exacerbation of experimental thyroiditis in the postpartum period. 61 54
11905847 2001
45
Gliadin antibodies in adult insulin-dependent diabetes--autoimmune and immunogenetic correlates. 54 61
11191281 2000
46
Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. 61 54
10634366 2000
47
New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. 54 61
11129116 2000
48
Autoantibodies to thyroglobulin in health and disease. 61 54
10826964 2000
49
Multicenter study on TGPO autoantibody prevalence in various thyroid and non-thyroid diseases; relationships with thyroglobulin and thyroperoxidase autoantibody parameters. 61 54
10601957 1999
50
[Increased serum soluble Fas ligand in hyperthyroid Graves' disease]. 54 61
10590671 1999

Variations for Thyroiditis

ClinVar genetic disease variations for Thyroiditis:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CEL NM_001807.5(CEL):c.1966G>C (p.Ala656Pro) SNV Uncertain significance 128688 rs587780309 GRCh37: 9:135946855-135946855
GRCh38: 9:133071468-133071468

Expression for Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for Thyroiditis

Pathways related to Thyroiditis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 TNF PTPN22 PRSS3 IL6 IL4 IL2
2
Show member pathways
13.4 TNF IL6 IL4 IL2 IL10 IFNG
3
Show member pathways
13.32 TNF PTPN22 IL6 IL4 IL2 IL10
4
Show member pathways
13.24 TNF IL6 IL2 IL10 IFNG IFNA1
5
Show member pathways
13.02 TNF IL6 IL4 IL2 IFNA1 FASLG
6 12.88 IL6 IL4 IL2 IFNG IFNA1 FASLG
7
Show member pathways
12.88 TNF PRSS3 IL6 IL2 IFNG IFNA1
8 12.82 TNF IL6 IFNG IFNA1 FASLG
9
Show member pathways
12.66 TNF IL4 IL2 IL10 IFNG
10
Show member pathways
12.66 TNF IL6 IL4 IL2 IL10 IFNG
11
Show member pathways
12.64 TNF IL6 IL4 IL2 IL10 IFNG
12
Show member pathways
12.63 TNF IL6 IL2 IL10 IFNG
13
Show member pathways
12.59 TNF IL4 IL2 IFNG IFNA1 FASLG
14
Show member pathways
12.48 IL6 IL4 IL2 IL10 IFNG IFNA1
15
Show member pathways
12.4 TNF IL6 IL4 IL2 IFNG
16
Show member pathways
12.35 TNF IL6 IL4 IFNG
17
Show member pathways
12.35 TNF IL6 IL2 IL10
18 12.31 TNF IL6 IL10 IFNG IFNA1
19
Show member pathways
12.3 TNF IL6 IL4 IL2 IL10 IFNG
20
Show member pathways
12.29 TNF IL4 IL10 IFNG
21
Show member pathways
12.26 TNF IL6 IL4 IFNG FASLG
22
Show member pathways
12.24 TNF IL6 IL2 IL10
23
Show member pathways
12.23 TNF IFNG IFNA1 FASLG
24
Show member pathways
12.21 TSHR TSHB TPO TNF TG IL6
25 12.17 TNF PTPN22 IL4 IL2 IL10 IFNG
26 12.13 TNF IL6 IL2 IL10
27 12.09 TNF IL6 IL4 IL2 IFNG
28 12.05 TNF IL6 IL4 IL10 FASLG
29
Show member pathways
12.03 IL4 IL2 IFNG FASLG
30 12.02 TNF IL6 IL4 IL2 IL10 IFNG
31 11.98 TNF IL6 IL10 IFNG
32 11.94 TNF IL6 IFNG CTLA4
33 11.88 IL6 IL4 IL2 IFNG
34 11.84 TNF IL4 IL2 IL10 IFNG
35
Show member pathways
11.8 TNF IL6 IL2 IL10 IFNG
36 11.78 TNF IL6 IL10
37
Show member pathways
11.78 IL4 IL2 FOXP3 FASLG
38 11.78 TNF IL6 IL2 IL10 IFNG
39
Show member pathways
11.75 TNF IL6 IL2 IFNG
40 11.75 TNF IL6 IL4 CALCA
41
Show member pathways
11.72 TNF IL2 IFNG FASLG
42
Show member pathways
11.68 TNF IL4 IL2 IFNG FOXP3 FASLG
43 11.66 TNF IL6 IL4 IL10 FOXP3 CTLA4
44 11.62 TNF IL6 IL10 IFNG
45 11.61 TNF IL6 IL4 IL10
46 11.6 TNF IL6 IL2 IFNG FASLG
47 11.56 TNF IL2 IFNG
48 11.52 IL4 IL2 IL10 IFNG FOXP3
49 11.48 TNF IL6 IFNG FASLG CALCA
50 11.41 TNF IL6 IL10

GO Terms for Thyroiditis

Cellular components related to Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TSHB TNF TG SERPINA7 PRSS3 IL6
2 extracellular space GO:0005615 9.47 TSHB TPO TNF TG SERPINA7 PRSS3

Biological processes related to Thyroiditis according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.22 TNF IL6 IL4 IL2 IL10 FOXP3
2 positive regulation of transcription, DNA-templated GO:0045893 10.15 TNF IL6 IL4 IL10 FOXP3 AIRE
3 positive regulation of cell proliferation GO:0008284 10.08 TSHR IL6 IL4 IL2 IFNG FASLG
4 positive regulation of gene expression GO:0010628 10.02 TNF PTPN22 IL6 IL4 IFNG FOXP3
5 response to lipopolysaccharide GO:0032496 9.95 PTPN22 IL10 FOXP3 FASLG
6 negative regulation of inflammatory response GO:0050728 9.91 IL4 IL2 IL10 FOXP3
7 cell-cell signaling GO:0007267 9.91 TSHR TSHB IL2 FASLG CALCA
8 regulation of insulin secretion GO:0050796 9.88 TNF IL6 IFNG
9 response to glucocorticoid GO:0051384 9.87 TNF IL6 IL10
10 positive regulation of interferon-gamma production GO:0032729 9.86 TNF PTPN22 IL2
11 positive regulation of T cell proliferation GO:0042102 9.86 IL6 IL4 IL2
12 positive regulation of interleukin-8 production GO:0032757 9.85 TNF IL6 CALCA
13 positive regulation of interleukin-1 beta production GO:0032731 9.84 TNF IL6 IFNG
14 positive regulation of cytokine production GO:0001819 9.84 TNF IL10 IFNG
15 extrinsic apoptotic signaling pathway GO:0097191 9.8 TNF IFNG FASLG
16 negative regulation of T cell proliferation GO:0042130 9.8 IL10 FOXP3 CTLA4
17 cytokine-mediated signaling pathway GO:0019221 9.8 TNF IL6 IL4 IL2 IL10 IFNA1
18 positive regulation of chemokine production GO:0032722 9.79 TNF IL6 IFNG
19 B cell differentiation GO:0030183 9.78 TSHR IL4 IL10 IFNA1
20 negative regulation of tumor necrosis factor production GO:0032720 9.76 PTPN22 IL4 IL10 FOXP3
21 positive regulation of JAK-STAT cascade GO:0046427 9.74 TNF IL6 IL10
22 microglial cell activation GO:0001774 9.73 TNF IL4 IFNG
23 negative regulation of interleukin-6 production GO:0032715 9.73 TNF PTPN22 IL10 FOXP3
24 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 TNF IL6 IL4 IL2 IFNG
25 negative regulation of amyloid-beta clearance GO:1900222 9.71 TNF IFNG
26 hormone biosynthetic process GO:0042446 9.71 TPO TG
27 positive regulation of isotype switching to IgG isotypes GO:0048304 9.7 IL4 IL2
28 negative regulation of lipid storage GO:0010888 9.7 TNF IL6
29 regulation of immunoglobulin production GO:0002637 9.7 TNF FOXP3
30 necroptotic signaling pathway GO:0097527 9.69 TNF FASLG
31 endothelial cell apoptotic process GO:0072577 9.69 TNF IL10
32 vascular endothelial growth factor production GO:0010573 9.68 TNF IL6
33 positive regulation of immunoglobulin production GO:0002639 9.67 IL6 IL2 IL10
34 positive regulation of mononuclear cell migration GO:0071677 9.66 TNF IL4
35 negative regulation of lymphocyte proliferation GO:0050672 9.65 IL2 FOXP3
36 negative regulation of cytokine production involved in immune response GO:0002719 9.65 TNF IL10
37 positive regulation of cellular respiration GO:1901857 9.64 IL4 IFNG
38 neuroinflammatory response GO:0150076 9.64 IL4 IFNG
39 type 2 immune response GO:0042092 9.63 IL4 IL10
40 positive regulation of plasma cell differentiation GO:1900100 9.6 IL2 IL10
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.59 TNF IFNG
42 regulation of isotype switching GO:0045191 9.58 IL4 IL10
43 negative regulation of chronic inflammatory response GO:0002677 9.58 IL4 FOXP3
44 positive regulation of MHC class II biosynthetic process GO:0045348 9.58 IL4 IL10 IFNG
45 humoral immune response GO:0006959 9.55 TNF IL6 IFNG IFNA1 AIRE
46 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 TNF IFNG
47 negative regulation of T-helper 17 cell differentiation GO:2000320 9.54 IL4 IL2 FOXP3
48 positive regulation of nitrogen compound metabolic process GO:0051173 9.52 TNF IFNG
49 immune response GO:0006955 9.28 TNF IL6 IL4 IL2 IL10 IFNG
50 regulation of regulatory T cell differentiation GO:0045589 9.26 IL2 IFNG FOXP3 CTLA4

Molecular functions related to Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 IL6 IL4 IL2 IL10
2 cytokine activity GO:0005125 9.23 TNF IL6 IL4 IL2 IL10 IFNG

Sources for Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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