MCID: THY032
MIFTS: 55

Thyroiditis

Categories: Endocrine diseases
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Aliases & Classifications for Thyroiditis

Summaries for Thyroiditis

MalaCards based summary: Thyroiditis, also known as inflammation of thyroid, is related to subacute thyroiditis and subacute lymphocytic thyroiditis. An important gene associated with Thyroiditis is TG (Thyroglobulin), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Celecoxib and Xylometazoline have been mentioned in the context of this disorder. Affiliated tissues include thyroid, t cells and lymph node, and related phenotypes are homeostasis/metabolism and growth/size/body region

Wikipedia: 75 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

Related Diseases for Thyroiditis

Diseases in the Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1515)
# Related Disease Score Top Affiliating Genes
1 subacute thyroiditis 33.1 TSHR TPO TNF TG IL6
2 subacute lymphocytic thyroiditis 32.8 TSHR TPO TG IL2
3 suppurative thyroiditis 32.6 TSHR TPO TG CALCA
4 acute thyroiditis 32.6 TPO TG CTLA4 CALCA
5 hashimoto thyroiditis 32.3 TSHR TPO TG PTPN22 PRSS3 IL4
6 graves disease 1 32.0 TSHR TPO TG CALCA
7 thyroid lymphoma 32.0 TPO TG CALCA
8 myxedema 31.9 TSHR TSHB TPO TG CTLA4
9 hypothyroidism, congenital, nongoitrous, 1 31.9 TSHR TSHB TG
10 endocrine exophthalmos 31.8 TSHR TPO TG IL6
11 thyrotoxic exophthalmos 31.8 TSHR TPO TG IL6
12 hyperthyroidism 31.8 TSHR TPO TNF TG IL6 CTLA4
13 goiter 31.7 TSHR TPO TG IL6 CALCA
14 immunodeficiency 41 with lymphoproliferation and autoimmunity 31.7 IL2 FOXP3 CTLA4
15 premature menopause 31.6 TPO TNF TG IL6 AIRE
16 papillary carcinoma 31.3 TSHR TPO TG CALCA
17 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 31.2 IL4 IL2 IL10 FOXP3 CTLA4 AIRE
18 graves' disease 31.1 TSHR TPO TG PTPN22 IL4 IFNG
19 nodular goiter 31.1 TSHR TPO TG CTLA4 CALCA
20 multinodular goiter 31.0 TSHR TPO TG CALCA
21 exophthalmos 31.0 TSHR TPO TG
22 nontoxic goiter 31.0 TSHR TPO TG FASLG CALCA
23 pernicious anemia 31.0 TPO TG PTPN22 AIRE
24 thyroid crisis 30.9 TSHR TPO TG
25 hypothyroidism 30.9 TSHR TSHB TPO TNF TG PTPN22
26 hypoadrenocorticism, familial 30.9 TPO TG PTPN22 CTLA4 AIRE
27 follicular adenoma 30.8 TSHR TPO TG CALCA
28 thyroid gland follicular carcinoma 30.8 TSHR TPO TG CALCA
29 goiter, multinodular 1, with or without sertoli-leydig cell tumors 30.8 TPO TG
30 hypoparathyroidism 30.8 TPO CTLA4 CALCA AIRE
31 thyroid gland cancer 30.7 TSHR TPO TG CALCA
32 chronic urticaria 30.7 TPO TG PTPN22 IL6 HLA-DRB1
33 papillary thyroid microcarcinoma 30.7 TG CALCA
34 gastritis 30.7 TNF IL6 IL4 IL10
35 covid-19 30.7 TNF IL6 IL4 IL2 IL10
36 vasculitis 30.7 TNF IL6 IL10 HLA-DRB1 CTLA4
37 graves ophthalmopathy 30.7 TSHR TNF TG IL6 IFNG CTLA4
38 thyroid cancer, nonmedullary, 2 30.6 TSHR TG CALCA
39 hepatitis c 30.6 IL6 IL10 IFNG IFNA1
40 inflammatory bowel disease 1 30.6 TNF IL6 IL10
41 postsurgical hypothyroidism 30.6 TSHR TPO TG
42 congenital hypothyroidism 30.6 TSHR TSHB TPO TNF TG
43 sarcoidosis 1 30.6 TNF IL6 IL2 IL10 IFNG HLA-DRB1
44 urticaria 30.5 TNF IL6 IL4 IL10 IFNG
45 autoimmune polyendocrine syndrome 30.5 TG PTPN22 IFNA1 FOXP3 AIRE
46 thyroid gland anaplastic carcinoma 30.5 TSHR TPO TG CALCA
47 sclerosing cholangitis 30.5 TNF IL6 IL10
48 plummer's disease 30.5 TSHR TPO TG CALCA
49 vitiligo-associated multiple autoimmune disease susceptibility 1 30.5 TPO TNF TG PTPN22 IL2 FOXP3
50 pericarditis 30.4 TNF IL6 IFNG

Comorbidity relations with Thyroiditis via Phenotypic Disease Network (PDN):


Hypothyroidism

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to Thyroiditis

Symptoms & Phenotypes for Thyroiditis

MGI Mouse Phenotypes related to Thyroiditis:

45 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 AIRE CALCA CTLA4 FASLG FOXP3 IFNG
2 growth/size/body region MP:0005378 10.34 AIRE FOXP3 HLA-DRB1 IFNG IL10 IL2
3 endocrine/exocrine gland MP:0005379 10.32 AIRE CTLA4 FASLG FOXP3 IFNG IL10
4 immune system MP:0005387 10.31 AIRE CTLA4 FASLG FOXP3 IFNA1 IFNG
5 liver/biliary system MP:0005370 10.26 AIRE CTLA4 FASLG FOXP3 IFNG IL10
6 digestive/alimentary MP:0005381 10.23 AIRE CTLA4 FASLG FOXP3 IFNG IL10
7 respiratory system MP:0005388 10.22 AIRE CALCA CTLA4 FASLG FOXP3 IFNA1
8 neoplasm MP:0002006 10.21 AIRE CALCA FASLG IFNG IL10 IL2
9 normal MP:0002873 10.2 AIRE CALCA CTLA4 FASLG FOXP3 IFNA1
10 reproductive system MP:0005389 10.15 AIRE FASLG FOXP3 IFNG IL10 IL2
11 skeleton MP:0005390 10.1 CALCA CTLA4 FASLG HLA-DRB1 IFNG IL10
12 no phenotypic analysis MP:0003012 10.08 AIRE FOXP3 IFNG IL10 IL2 IL4
13 hematopoietic system MP:0005397 10.06 AIRE CTLA4 FASLG FOXP3 IFNA1 IFNG
14 vision/eye MP:0005391 10 AIRE FASLG FOXP3 IFNG IL10 IL2
15 mortality/aging MP:0010768 9.8 AIRE CALCA CTLA4 FASLG FOXP3 IFNG
16 integument MP:0010771 9.32 CALCA CTLA4 FASLG FOXP3 IFNG IL10

Drugs & Therapeutics for Thyroiditis

Drugs for Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 77)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
2
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
3
Acetylsalicylic acid Approved, Vet_approved Phase 4 50-78-2 2244
4
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
5 Hormones Phase 4
6 Hormone Antagonists Phase 4
7 glucocorticoids Phase 4
8 Antineoplastic Agents, Hormonal Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Cyclooxygenase Inhibitors Phase 4
11 Fibrinolytic Agents Phase 4
12 Antirheumatic Agents Phase 4
13 Platelet Aggregation Inhibitors Phase 4
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4
15 Antipyretics Phase 4
16 Analgesics, Non-Narcotic Phase 4
17 Analgesics Phase 4
18
Selenium Approved, Investigational, Vet_approved Phase 2 7783-07-5, 7782-49-2 533
19
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
20
Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
21
Prednisolone Approved, Vet_approved Phase 2 50-24-8 4894 5755
22
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5 1875
23
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 4159 6741
24
Hydroxychloroquine Approved Phase 2 118-42-3 3652
25
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7 4897
26 Protective Agents Phase 2
27 Autoantibodies Phase 2
28 gamma-Globulins Phase 2
29
Methylprednisolone Acetate Phase 2 584547
30 Rho(D) Immune Globulin Phase 2
31 Immunoglobulins, Intravenous Phase 2
32
Methimazole Approved 60-56-0 1349907
33
Propylthiouracil Approved, Investigational 51-52-5 657298
34
Racepinephrine Approved, Vet_approved 51-43-4, 329-65-7 838 5816
35
Epitestosterone Approved, Experimental, Investigational 481-30-1, 58-22-0 5408 10204 6013
36
Triamcinolone Approved, Vet_approved 124-94-7 31307
37
Iodine Approved, Investigational 7553-56-2 807
38
Calcium carbonate Approved, Investigational 471-34-1
39
Amiodarone Approved, Investigational 1951-25-3 2157
40
Racemethionine Approved, Experimental, Investigational, Nutraceutical 59-51-8, 63-68-3, 348-67-4 6137
41
Cholecalciferol Approved, Nutraceutical, Vet_approved 67-97-0, 1406-16-2 5280795 10883523
42
Ascorbic acid Approved, Nutraceutical 50-81-7 54676860 54670067 5785
43
L-Glutamine Approved, Investigational, Nutraceutical 56-85-9 5961
44
Ergocalciferol Approved, Nutraceutical 50-14-6 5280793
45
Calcitriol Approved, Nutraceutical 32222-06-3 5280453
46
Cadexomer iodine Experimental 94820-09-4
47 Antithyroid Agents
48 Antimetabolites
49 Antioxidants
50 Mitogens

Interventional clinical trials:

(show top 50) (show all 53)
# Name Status NCT ID Phase Drugs
1 L-selenomethionine Supplementation in Children and Adolescents With Autoimmune Thyroiditis: a Randomized Blind Placebo-controlled Clinical Trial Completed NCT02644707 Phase 4
2 Efficiency and Safety Study of Short-term Prednisone to Treat Moderate and Severe Subacute Thyroiditis Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
3 Effect of Prednisone and Aspirin on Pregnancy Outcomes After Embryo Transfer Among Patients With Thyroid Autoimmunity: a Randomized Clinical Trial Not yet recruiting NCT05578456 Phase 4 Prednisone and Aspirin;Placebo
4 Effect of Supplementation of Two Doses of L-selenomethionine (Semet; 80 and 160 mcg) Versus Placebo in Patients With Chronic Autoimmune Thyroiditis (AIT) With Normal Thyroid Function. Unknown status NCT02302768 Phase 2
5 A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Trial to Evaluate the Safety and Potential Effects of the Dietary Supplement Anatabloc on Antithyroid Autoantibodies and Thyroid Function in Autoimmune Thyroiditis Completed NCT01551498 Phase 2
6 Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis: Randomized, Placebo Controlled Clinical Trial Completed NCT01129492 Phase 2
7 The Role of Immunomodulatory Treatment in Success of ICSI in Patients Who Have Infertility With Autoimmune Thyroiditis Completed NCT03289403 Phase 2 Immunomodulatory;Thyroxine
8 Involvement of Polyomaviruses in the Pathogenesis of Autoimmune Thyroiditis and Goitrigenesis. Unknown status NCT03103776
9 The Oral Microbiota in Autoimmune Thyroiditis is Distinctive And Predictive Unknown status NCT03447093 Methimazole Pill;Propylthiouracil Pill
10 Correlation Between Different Levels of Thyroid Peroxidase Antibody and Postpartum Thyroiditis in Early Pregancy Unknown status NCT03641638
11 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Hydroxychloroquine
12 Association of Serum Fibroblast Growth Factor 21 (FGF-21) Levels With Resting Metabolic Rate (RMR), in Children and Adolescents With Hashimoto's Thyroiditis. Unknown status NCT02725879
13 CXCL9 and CXCL11 Levels in Patients With Autoimmune Thyroiditis and Habitual Abortions Unknown status NCT01644318
14 Pre-and Post-operative Risk Factors Affecting the Incidence and Severity of Dysphagia Following Total Thyroidectomy: An International Multi-centric Prospective Randomized Controlled Clinical Trial (RCT) Unknown status NCT04410601
15 Selenium Treatment in Autoimmune Thyroiditis: Long Term Follow-Up With Variable Doses Completed NCT00271427 L-Selenomethionine
16 The Effects of Eye Movement Desensitization and Reprocessing on Autoimmune Thyroiditis in Adults: a Randomized Controlled Trial Completed NCT04472988 Treatment as Usual
17 Long-term Follow-up After Treatment of Chronic Autoimmune Thyroiditis With Low Level Laser Completed NCT02240563
18 Changes in Thyroid Function Tests and Texture Following Bariatric Surgery Induced Weight Loss Completed NCT03048708
19 Selenium Supplementation Treatment in Euthyroid Pregnant Women With Autoimmune Thyroid Disease: Effects on Obstetrical Complications Completed NCT01465867
20 Serum Antibodies Against the Insulin-like Growth Factor-1 Receptor (IGF-1R) in Graves' Disease and Graves' Orbitopathy Completed NCT03498417
21 The Impact of Pituitary-thyroid and Pituitary-adrenal Axes Function on COVID-19 Clinical Course. Completed NCT05070091
22 The Influence of Identity Oriented Psychotrauma Therapy on Hashimoto Disease Activity: a Randomized Controlled Trial Completed NCT04600349 Treatment as Usual
23 Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis Completed NCT03114267
24 Thyroid Function and Structure IN Klinefelter Syndrome Completed NCT05581147
25 Oxidative Status in Children and Adolescents With Autoimmune Thyroiditis: A Tertiary Center Study From Upper Egypt Completed NCT02318160
26 Randomized Placebo Controlled Clinical Study of Anethum Graveolens L. (Dill) in Thyroiditis and Nodular Goiter Patients Completed NCT04482907
27 Is There Any Association Between Thyroid Cancer and Hashimotos Thyroiditis? Completed NCT01428167
28 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487 synacthen
29 Differential Diagnosis Value of Peak Systolic Velocity of Thyroid Superior Artery Using Color Flow Doppler Sonography in Transient Thyrotoxicosis Caused by Thyroiditis and Graves Disease Completed NCT01227499
30 Sonographic Characterization of the Thyroid Gland in Patients With Systemic Sclerosis With and Without Hashimoto Thyroiditis Completed NCT01270425
31 Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis Completed NCT01884649
32 The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis Completed NCT01760421 Hydroxychloroquine
33 Clinical Application of Continuous Monitoring Data for the Pulse Rate, Exercise, and Calorie Intake by Wearable Activity Trackers in the Patients With Thyrotoxicosis Completed NCT03009357
34 Determining the Association Between Spontaneous Coronary Artery Dissection (SCAD) and Autoimmunity Completed NCT03941184
35 Thyroid Disorders in Malaysian: A Nationwide Multicentre Study Completed NCT02190214
36 Study of DNA Methylation in Children and Adolescents With Autoimmune Thyroid Diseases Completed NCT02491567
37 Effects of Low-Level Laser Therapy on Oxidative Stress Levels, Fatigue and Quality of Life in Patients With Hashimoto Thyroiditis Recruiting NCT04754607
38 The Effect of Thyroid Antibodies on Female Reproductive Function and Pregnancy Outcomes Recruiting NCT04952012 LT4
39 Study on the Effect of Selenium Supplementation on the Structure and Function of Autoimmune Thyroiditis Recruiting NCT04942769 Selenium
40 Effectiveness of Cervical Rehabilitation Program on Neck Pain, ROM and Disability After Thyroidectomy. Recruiting NCT05497752
41 Study of Metabolic Pathways for the Identification of Biomarkers in Hashimoto's Thyroiditis and Psoriasis Recruiting NCT04693936
42 The Clinical Value of Microvascular Ultrasonography in Real-time Differential Diagnosis of Thyrotoxic Patients Between Hyperthyroidism and Thyroiditis Recruiting NCT04879173
43 Effect of Vitamin D Supplementation on Autoimmunity and Thyroid Function in Subjects With Hashimoto's Thyroiditis and Vitamin D Deficiency: Clinical Pilot Trial. Recruiting NCT04778865
44 The Chronic Autoimmune Thyroiditis Quality Of Life Selenium Trial Active, not recruiting NCT02013479
45 Does Gluten Sensitivity Play a Role in Development of Thyroiditis Active, not recruiting NCT04974255
46 The Epidemiology, Management, and the Associated Burden of Mental Health, Atopic and Autoimmune Conditions, and Common Infections in Alopecia Areata Active, not recruiting NCT04239521
47 n Vitro Effect Study of Interleukin-2 Muteins on Regulatory T Cells of Patients With Different Autoimmune, Allo-immune or Inflammatory Diseases Not yet recruiting NCT05544448
48 Management of Thyroid Function in Hashimoto's Thyroiditis During Pregnancy: Real-word Experience in a Secondary Endocrine Centre in Italy Not yet recruiting NCT04613323
49 Comparison of Routine Prophylactic Calcium + Calcitriol and Selective Use Based on PTH for the Prevention of Postoperative Hypocalcemia in Patients With Total Thyroidectomy. Randomized Clinical Trial Not yet recruiting NCT05252884 routine postoperative calcium and calcitriol
50 Pilot Study for Treatment of Amiodarone-Induced Thyroiditis With Radiofrequency Ablation Terminated NCT03720210

Search NIH Clinical Center for Thyroiditis

Cochrane evidence based reviews: thyroiditis

Genetic Tests for Thyroiditis

Anatomical Context for Thyroiditis

Organs/tissues related to Thyroiditis:

MalaCards : Thyroid, T Cells, Lymph Node, Pituitary, Eye, Bone Marrow, B Cells

Publications for Thyroiditis

Articles related to Thyroiditis:

(show top 50) (show all 15674)
# Title Authors PMID Year
1
Hepatitis C and interferon induced thyroiditis. 53 62
20022216 2010
2
Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases? 53 62
20464711 2010
3
Dynamic changes of IgG subtypes of thyroid peroxidase antibody in patients with postpartum thyroiditis. 53 62
19829002 2010
4
Painless thyroiditis complicated by acromegaly. 53 62
20075583 2010
5
Interferon induced thyroiditis. 53 62
19942147 2009
6
Expression of CD152 (CTLA-4) in children with autoimmune thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene. 53 62
20134044 2009
7
49A/G and CT60 polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4 gene associated with autoimmune thyroid disease. 53 62
19559744 2009
8
Cytomorphologic study of Hashimoto's thyroiditis and its serologic correlation: a study of 150 cases. 53 62
19798877 2009
9
Different phenotypy in three siblings with homocystinuria. 53 62
19430269 2009
10
Silent thyroiditis, isolated corticotropin deficiency, and alopecia universalis in a patient with ulcerative colitis and elevated levels of plasma factor VIII: an unusual case of autoimmune polyglandular syndrome type 3. 53 62
19289325 2009
11
[Thyroid disorders during pregnancy]. 53 62
19142837 2009
12
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma. 53 62
19606248 2009
13
Evaluation of the role of ultrasonography in diagnosis of autoimmune thyroiditis in goitrous children. 53 62
18451445 2008
14
Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodies. 53 62
18029466 2008
15
A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes. 53 62
18489063 2008
16
Interferon alpha treatment and thyroid dysfunction. 53 62
17983936 2007
17
Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis. 53 62
17887926 2007
18
Obstetric management of thyroid disease. 53 62
17868484 2007
19
[Epidemiologic study of autoimmune thyroid disease in south Tunisia]. 53 62
17194970 2006
20
By-stander activation in autoimmune thyroiditis: studies on experimental autoimmune thyroiditis in the GFP+ fluorescent mouse. 53 62
16916620 2006
21
Circulating level of the platelet-derived CXC chemokine platelet factor 4 in chronic urticaria patients with or without coexistent euthyroid Hashimoto's thyroiditis. 53 62
16891214 2006
22
Clinical and laboratory aspects of thyroid autoantibodies. 53 62
16704751 2006
23
Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease. 53 62
16498048 2006
24
Thyroid hormone increases mannan-binding lectin levels. 53 62
16260422 2005
25
Graves' hyperthyroidism showing transient hypothyroidism during interferon therapy for chronic hepatitis type C. 53 62
16006723 2005
26
Thyroid disorders associated with pregnancy: etiology, diagnosis, and management. 53 62
15649099 2005
27
Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice. 53 62
15320899 2004
28
Inducing Graves' ophthalmopathy. 53 62
15164995 2004
29
[Clinical implications of occurrence of antithyroid antibodies in pregnant women and in the postpartum period]. 53 62
15789919 2004
30
[Subclinical thyroid disease--should we treat, should we screen for it?]. 53 62
15114790 2003
31
Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b. 53 62
14611699 2003
32
Consequences of autoimmune thyroiditis before, during and after pregnancy. 53 62
14605606 2003
33
Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen. 53 62
12780686 2003
34
Interferon-alpha and autoimmune thyroid disease. 53 62
12930598 2003
35
Extrapancreatic autoimmune manifestations in type 1 diabetes patients and their first-degree relatives: a multicenter study. 53 62
12663603 2003
36
Induction of murine thyroiditis by a non dominant E(k)-restricted peptide of human thyroglobulin. 53 62
12667218 2003
37
[Hypothyroidism: clinical and economical implications in a health area]. 53 62
12756897 2003
38
[Interferon-alpha and auto-immunity]. 53 62
12481406 2002
39
Temporal relationship between the appearance of thyroid autoantibodies and development of destructive thyroiditis in patients undergoing treatment with two different type-1 interferons for HCV-related chronic hepatitis: a prospective study. 53 62
12150338 2002
40
[Anti thyroglobulin antibodies in the follow up of patients with differentiated thyroid cancer: residual or relapsing disease markers?]. 53 62
11974529 2002
41
Expression of CD40 and apoptosis related molecules in autoimmune thyroid diseases. 53 62
11675676 2001
42
Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. 53 62
11588143 2001
43
Pregnancy and murine thyroiditis: thyroglobulin immunization leads to fetal loss in specific allogeneic pregnancies. 53 62
11159855 2001
44
Non-MHC driven exacerbation of experimental thyroiditis in the postpartum period. 53 62
11905847 2001
45
Gliadin antibodies in adult insulin-dependent diabetes--autoimmune and immunogenetic correlates. 53 62
11191281 2000
46
Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. 53 62
10634366 2000
47
Autoantibodies to thyroglobulin in health and disease. 53 62
10826964 2000
48
New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. 53 62
11129116 2000
49
Multicenter study on TGPO autoantibody prevalence in various thyroid and non-thyroid diseases; relationships with thyroglobulin and thyroperoxidase autoantibody parameters. 53 62
10601957 1999
50
H2-E transgenic class II-negative mice can distinguish self from nonself in susceptibility to heterologous thyroglobulins in autoimmune thyroiditis. 53 62
10541803 1999

Variations for Thyroiditis

ClinVar genetic disease variations for Thyroiditis:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 CEL NM_001807.6(CEL):c.1966G>C (p.Ala656Pro) SNV Uncertain Significance
128688 rs587780309 GRCh37: 9:135946855-135946855
GRCh38: 9:133071468-133071468

Expression for Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for Thyroiditis

Pathways related to Thyroiditis according to GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 TNF PTPN22 PRSS3 IL6 IL4 IL2
2
Show member pathways
13.63 TNF IL6 IL4 IL2 IL10 IFNG
3
Show member pathways
13.35 TNF IL6 IL4 IL2 IL10 IFNG
4
Show member pathways
13.31 TNF PTPN22 IL6 IL4 IL2 IL10
5
Show member pathways
12.85 TNF IL6 IL4 IL2 HLA-DRB1
6
Show member pathways
12.84 TNF IL6 IL2 IFNA1 FASLG
7
Show member pathways
12.68 TNF IL6 IL4 IL2 IL10 IFNG
8
Show member pathways
12.62 TNF IL6 IL2 IL10 IFNG
9
Show member pathways
12.47 TNF IL6 IL4 IFNG FASLG
10 12.37 TNF PTPN22 IL4 IL2 IL10 IFNG
11
Show member pathways
12.26 TNF IL4 IL2 IFNG FASLG
12 12.17 IFNG IL10 IL4 IL6 TNF
13
Show member pathways
12.13 TNF IL4 IL2 IL10 IFNG HLA-DRB1
14
Show member pathways
12.09 IL4 IL2 IFNG FOXP3 FASLG
15 12.06 TNF IL6 IL4 IL2 IFNG
16 12.04 IFNG IL10 IL2 IL4 IL6 TNF
17 12.03 TNF IL6 IL4 IL10 FASLG
18
Show member pathways
12.02 IL4 IL2 IFNG FASLG
19
Show member pathways
11.99 TNF IL6 IL2 IL10 IFNG
20 11.87 TNF IL4 IL2 IL10 IFNG
21
Show member pathways
11.86 IL6 IL4 IFNG
22 11.86 IL6 IFNG IFNA1
23 11.84 IFNG IL2 IL4 IL6
24 11.83 IL6 IL2 IL10 IFNG
25 11.82 TNF IL6 IL2 IL10 IFNG
26 11.78 IL6 IL4 IL2 IFNG FOXP3
27 11.77 IL6 IL4 IL2 IL10 IFNG
28 11.76 TNF IL6 IL4 IL2 IL10 IFNG
29
Show member pathways
11.74 TNF IL6 IL2 IFNG
30 11.74 TNF IL6 IL4 CALCA
31
Show member pathways
11.69 CTLA4 FASLG FOXP3 IFNG IL2 IL4
32 11.68 IL10 IL6 TNF
33 11.67 IL10 IL6 TNF
34 11.61 IL6 IL2 IFNG
35 11.6 TNF IL4 IL2 IL10 IFNG HLA-DRB1
36 11.58 TNF IL6 IFNG
37 11.57 IL4 IL2 IL10 IFNG FOXP3
38
Show member pathways
11.57 TNF IL6 IL4 IL2 IL10 IFNG
39 11.54 TNF IL6 IL10
40 11.53 TNF IL6 FASLG
41 11.53 TNF IL6 IFNG FASLG CALCA
42 11.4 TNF IL6 IL10
43
Show member pathways
11.4 TNF IL2 IL10 IFNG FOXP3 FASLG
44 11.39 TNF IL6 IL4 IFNG
45 11.38 IL4 IL2 IFNG
46 11.3 TNF IL6 IFNA1
47 11.29 IFNG IL10 IL2 IL4
48 11.24 TNF IL4 IL2 IL10 IFNG HLA-DRB1
49 11.14 TSHR TPO TG
50 11.09 PTPN22 HLA-DRB1 CTLA4

GO Terms for Thyroiditis

Cellular components related to Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.03 TSHB TNF TG PRSS3 IL6 IL4
2 extracellular space GO:0005615 9.77 CALCA FASLG HLA-DRB1 IFNA1 IFNG IL10

Biological processes related to Thyroiditis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.48 TSHR TNF TG IL6 IL4 IL10
2 cell-cell signaling GO:0007267 10.25 TSHR TSHB IL2 FASLG CALCA
3 T cell receptor signaling pathway GO:0050852 10.19 CTLA4 FOXP3 HLA-DRB1 PTPN22
4 negative regulation of inflammatory response GO:0050728 10.17 IL4 IL2 IL10 FOXP3
5 regulation of insulin secretion GO:0050796 10.14 TNF IL6 IFNG
6 response to activity GO:0014823 10.13 TNF IL6 IL10
7 negative regulation of type II interferon production GO:0032689 10.12 IL10 HLA-DRB1 FOXP3
8 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.09 IL10 IL6 TNF
9 negative regulation of tumor necrosis factor production GO:0032720 10.08 PTPN22 IL4 IL10 FOXP3
10 B cell differentiation GO:0030183 10.07 TSHR IL4 IL10 IFNA1
11 liver regeneration GO:0097421 10.06 TNF IL6 IL10
12 negative regulation of interleukin-6 production GO:0032715 10.06 FOXP3 IL10 PTPN22 TNF
13 response to lipopolysaccharide GO:0032496 10.03 TNF PTPN22 IL10 FOXP3 FASLG
14 positive regulation of immunoglobulin production GO:0002639 10.02 IL6 IL2 IL10
15 microglial cell activation GO:0001774 10.01 IFNG IL4 TNF
16 positive regulation of chemokine production GO:0032722 9.97 AIRE IFNG IL6 TNF
17 negative regulation of cytokine production involved in immune response GO:0002719 9.94 IL10 TNF
18 positive regulation of mononuclear cell migration GO:0071677 9.94 IL4 TNF
19 positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation GO:0032831 9.93 HLA-DRB1 FOXP3
20 negative regulation of T cell proliferation GO:0042130 9.92 IL10 HLA-DRB1 FOXP3 CTLA4
21 regulation of isotype switching GO:0045191 9.91 IL4 IL10
22 negative regulation of chronic inflammatory response GO:0002677 9.91 IL4 FOXP3
23 positive regulation of plasma cell differentiation GO:1900100 9.88 IL2 IL10
24 positive regulation of MHC class II biosynthetic process GO:0045348 9.88 IL4 IL10 IFNG
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.87 TNF IFNG
26 positive regulation of nitrogen compound metabolic process GO:0051173 9.86 TNF IFNG
27 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.85 IFNG IL2 IL4 IL6 TNF
28 negative regulation of lymphocyte proliferation GO:0050672 9.83 IL2 FOXP3
29 positive regulation of vitamin D biosynthetic process GO:0060557 9.81 TNF IFNG
30 chronic inflammatory response to antigenic stimulus GO:0002439 9.8 TNF IL10
31 negative regulation of T-helper 17 cell differentiation GO:2000320 9.73 IL4 IL2 FOXP3
32 humoral immune response GO:0006959 9.73 TNF IL6 IFNG IFNA1 HLA-DRB1 AIRE
33 immune response GO:0006955 9.5 TNF IL6 IL4 IL2 IL10 IFNG

Molecular functions related to Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.53 TNF IL6 IL4 IL2 IL10 IFNG

Sources for Thyroiditis

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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