MCID: THY032
MIFTS: 53

Thyroiditis

Categories: Endocrine diseases, Infectious diseases

Aliases & Classifications for Thyroiditis

MalaCards integrated aliases for Thyroiditis:

Name: Thyroiditis 12 54 6 43 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:7166
ICD9CM 34 245 245.9
MeSH 43 D013966
NCIt 49 C26894
SNOMED-CT 67 82119001
ICD10 32 E06 E06.9
UMLS 71 C0040147

Summaries for Thyroiditis

MalaCards based summary : Thyroiditis is related to thyroid carcinoma, familial medullary and familial thyroid dyshormonogenesis. An important gene associated with Thyroiditis is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and NF-kappaB Signaling. The drugs Celecoxib and Xylometazoline have been mentioned in the context of this disorder. Affiliated tissues include thyroid, t cells and pituitary, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Wikipedia : 74 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

Related Diseases for Thyroiditis

Diseases in the Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2732)
# Related Disease Score Top Affiliating Genes
1 thyroid carcinoma, familial medullary 34.8 TG RET NKX2-1 CALCA
2 familial thyroid dyshormonogenesis 34.8 TPO TG
3 subacute thyroiditis 34.8 TSHR TPO TG SERPINA7
4 thyroid gland anaplastic carcinoma 34.7 TPO TG RET NKX2-1
5 thyroid cancer, nonmedullary, 2 34.7 TSHR THRB TG CALCA
6 thyroid sarcoma 34.6 TG CALCA
7 thyroid gland medullary carcinoma 34.5 TG RET CALCA
8 thyroid gland mucoepidermoid carcinoma 34.5 TG CALCA
9 thyroid gland papillary carcinoma 34.4 TG RET NKX2-1
10 thyroid carcinoma 34.4 TSHR TPO TG RET NKX2-1 CALCA
11 thyroid angiosarcoma 34.4 TG NKX2-1 CALCA
12 hypothyroidism, congenital, nongoitrous, 2 34.4 TSHR TPO TG SERPINA7 NKX2-1
13 acute thyroiditis 34.3 TPO TG CALCA
14 thyroid crisis 34.3 TSHR TPO THRB TG SERPINA7
15 multicentric papillary thyroid carcinoma 34.3 TG RET
16 generalized resistance to thyroid hormone 34.3 TRH THRB
17 thyroid hormone resistance, generalized, autosomal dominant 34.2 TSHR TSHB TRH THRB TG SERPINA7
18 differentiated thyroid carcinoma 34.2 TSHR TPO TG RET NKX2-1
19 thyroid gland follicular carcinoma 34.1 TSHR TG RET NKX2-1 CALCA
20 thyroid gland cancer 34.1 TSHR TPO THRB TG RET NKX2-1
21 papillary thyroid microcarcinoma 34.0 TSHR TG NKX2-1 CALCA
22 thyroid tumor 34.0 TPO THRB TG RET
23 hashimoto encephalopathy 33.7 TSHR TPO
24 allan-herndon-dudley syndrome 33.6 TRH THRB SERPINA7
25 congenital hypothyroidism 33.4 TSHR TSHB TPO TG SERPINA7 NKX2-1
26 hyperthyroidism 33.3 TSHR TRH TPO THRB TG SERPINA7
27 goiter, multinodular 1, with or without sertoli-leydig cell tumors 33.2 TPO TG
28 subacute lymphocytic thyroiditis 33.2 TSHR TPO TG IL2 IFNA1
29 thyroid gland disease 33.1 TSHR TSHB TRH TPO THRB TG
30 myxedema 32.9 TSHR TPO THRB TG CTLA4
31 euthyroid sick syndrome 32.9 TRH TG SERPINA7
32 follicular adenoma 32.9 TSHR TPO TG RET NKX2-1 CALCA
33 struma ovarii 32.8 TSHR TG RET NKX2-1
34 tall cell variant papillary carcinoma 32.8 TG RET NKX2-1
35 graves' disease 32.7 TSHR TPO THRB TG SERPINA7 PTPN22
36 spindle epithelial tumor with thymus-like differentiation tumor 32.7 TG CALCA
37 mucoepidermoid carcinoma 32.7 TG NKX2-1 CALCA
38 endemic goiter 32.7 TSHR TSHB TPO TG SERPINA7 CALCA
39 hypothyroidism, central, with testicular enlargement 32.7 TSHB TRH
40 hypoparathyroidism 32.7 RET CTLA4 CALCA
41 turner syndrome 32.6 TPO TG SERPINA7 INS
42 graves disease 1 32.6 TSHR TRH TPO THRB TG SERPINA7
43 multinodular goiter 32.6 TSHR TPO TG NKX2-1 IL10 CALCA
44 pituitary hormone deficiency, combined, 2 32.5 TSHB TRH INS
45 goiter 32.4 TSHR TRH TPO THRB TG SERPINA7
46 hyperthyroxinemia 32.4 TSHR TRH TPO THRB SERPINA7
47 nontoxic goiter 32.4 TSHR TPO TG SERPINA7 FASLG CALCA
48 vitiligo-associated multiple autoimmune disease susceptibility 1 32.2 TPO TG PTPN22 IL2 CTLA4
49 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 32.2 IL2 IL10 FOXP3 CTLA4
50 plummer's disease 32.1 TSHR TPO THRB TG

Comorbidity relations with Thyroiditis via Phenotypic Disease Network (PDN):


Hypothyroidism

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to Thyroiditis

Symptoms & Phenotypes for Thyroiditis

MGI Mouse Phenotypes related to Thyroiditis:

45 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.36 CTLA4 FASLG FOXP3 IL10 IL2 INS
2 growth/size/body region MP:0005378 10.31 FOXP3 IL10 IL2 INS NKX2-1 PTPN22
3 digestive/alimentary MP:0005381 10.3 CTLA4 FASLG FOXP3 IL10 IL2 INS
4 homeostasis/metabolism MP:0005376 10.3 CTLA4 FASLG FOXP3 IL10 IL2 INS
5 cardiovascular system MP:0005385 10.28 CTLA4 FASLG FOXP3 IL10 IL2 INS
6 hematopoietic system MP:0005397 10.26 CTLA4 FASLG FOXP3 IL10 IL2 INS
7 immune system MP:0005387 10.21 CTLA4 FASLG FOXP3 IL10 IL2 INS
8 limbs/digits/tail MP:0005371 9.95 FOXP3 IL10 RET TG THRB TPO
9 liver/biliary system MP:0005370 9.91 CTLA4 FASLG FOXP3 IL10 IL2 INS
10 neoplasm MP:0002006 9.87 FASLG IL10 IL2 NKX2-1 RET THRB
11 no phenotypic analysis MP:0003012 9.86 FOXP3 IL10 IL2 INS NKX2-1 RET
12 reproductive system MP:0005389 9.85 FASLG FOXP3 IL10 IL2 INS NKX2-1
13 respiratory system MP:0005388 9.61 CTLA4 FASLG FOXP3 IL10 IL2 NKX2-1
14 skeleton MP:0005390 9.32 CTLA4 FASLG IL10 INS NKX2-1 TG

Drugs & Therapeutics for Thyroiditis

Drugs for Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 118)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
2
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
3
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
4
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
7
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
8
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
9 Orange Approved Phase 4
10
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
11 glucocorticoids Phase 4
12 Methylprednisolone Acetate Phase 4
13 Antiemetics Phase 4
14 Gastrointestinal Agents Phase 4
15 Neuroprotective Agents Phase 4
16 Autonomic Agents Phase 4
17
Iodine Approved, Investigational Phase 3 7553-56-2 807
18
Ribavirin Approved Phase 3 36791-04-5 37542
19
Propylthiouracil Approved, Investigational Phase 3 51-52-5 657298
20
tannic acid Approved Phase 3 1401-55-4
21
Benzocaine Approved, Investigational Phase 3 1994-09-7, 94-09-7 2337
22
Carbimazole Approved, Investigational Phase 3 22232-54-8 31072
23 Immunologic Factors Phase 3
24 Anti-Infective Agents Phase 3
25 Micronutrients Phase 3
26 Nutrients Phase 3
27 Trace Elements Phase 3
28 cadexomer iodine Phase 3
29 Anti-Infective Agents, Local Phase 3
30 Antiviral Agents Phase 3
31 interferons Phase 3
32 Interferon alpha-2 Phase 3
33 Interferon-alpha Phase 3
34 Antithyroid Agents Phase 3
35 Hormone Antagonists Phase 3
36 Hormones Phase 3
37 Antimetabolites Phase 3
38
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
39
Methimazole Approved Phase 2 60-56-0 1349907
40
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
41
Hydroxychloroquine Approved Phase 2 118-42-3 3652
42
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
43
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
44
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
45
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
46
Pidilizumab Investigational Phase 1, Phase 2 1036730-42-3
47 Antineoplastic Agents, Immunological Phase 1, Phase 2
48 Immunoglobulin G Phase 1, Phase 2
49 Antirheumatic Agents Phase 2
50 Fibrinolytic Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 78)
# Name Status NCT ID Phase Drugs
1 L-selenomethionine Supplementation in Children and Adolescents With Autoimmune Thyroiditis: a Randomized Blind Placebo-controlled Clinical Trial Unknown status NCT02644707 Phase 4
2 Efficiency and Safety Study of Short-term Prednisone to Treat Moderate and Severe Subacute Thyroiditis Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
3 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
4 Pilot Double-Blind Placebo Controlled Trial of Levothyroxine in Pregnant Systemic Lupus Erythematosus (SLE) Patients With Autoimmune Thyroid Disease Withdrawn NCT01276782 Phase 4 Levothyroxine
5 An Open Labelled, Active Controlled, Three Arm, Parallel- Group Study of the Safety and Efficacy of Renessans Administered Alone and in Combination With Standard Interferon Therapy in Patients Chronic HCV Hepatitis Unknown status NCT01463592 Phase 3 Interferon Alfa-2b AND RIBAVIRIN
6 A Randomised Study of Two Anti-thyroid Drug Treatment Regimens in Young People Completed NCT01436994 Phase 3 carbimazole;propylthiouracil;thyroxine
7 Effect of Supplementation of Two Doses of L-selenomethionine (Semet; 80 and 160 mcg) Versus Placebo in Patients With Chronic Autoimmune Thyroiditis (AIT) With Normal Thyroid Function. Unknown status NCT02302768 Phase 2
8 A Phase I/ II Clinical Trial of MDV9300 (Pidilizumab) in Diffuse Intrinsic Pontine Glioma Unknown status NCT01952769 Phase 1, Phase 2
9 A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Trial to Evaluate the Safety and Potential Effects of the Dietary Supplement Anatabloc on Antithyroid Autoantibodies and Thyroid Function in Autoimmune Thyroiditis Completed NCT01551498 Phase 2
10 Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis: Randomized, Placebo Controlled Clinical Trial Completed NCT01129492 Phase 2
11 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
12 A Pilot Study of the Role of Methimazole in Patients With Polymyositis and Dermatomyositis Completed NCT00001421 Phase 2 methimazole
13 The Role of Immunomodulatory Treatment in Success of ICSI in Patients Who Have Infertility With Autoimmune Thyroiditis Recruiting NCT03289403 Phase 2 Immunomodulatory;Thyroxine
14 Can Levothyroxine Treatment Reduce the Development of Cardio-metabolic Disorder in Subclinical Hypothyroidism? Not yet recruiting NCT04178928 Phase 1, Phase 2 Levothyroxine
15 Treatment of IgG4-Related Disease With Revlimid and Rituximab: The TIGR2 Trial Completed NCT02705638 Phase 1 Rituximab;Lenalidomide
16 Phase 1 Single-Dose Study of the Pharmacokinetics of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects Completed NCT01581463 Phase 1 Liothyronine, Sodium
17 CXCL9 and CXCL11 Levels in Patients With Autoimmune Thyroiditis and Habitual Abortions Unknown status NCT01644318
18 Cases of Goiter in Children Attending Assiut University Children Hospital Unknown status NCT03202160
19 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Hydroxychloroquine
20 The Association of Costimulatory Molecules and PPAR-polymorphisms With Autoimmune Thyroid Disease in Taiwan Unknown status NCT01260532
21 Autoantibodies in Patients With Type 1 Diabetes Mellitus Unknown status NCT00173628
22 Observative and Community Study, Using Nailfold Video-capillaroscopy in Order to Assess the Prevalence of Pathological Changes in the Capillaries in First Grade Family Members of Patient Diagnosed With Systemic Sclerosis Unknown status NCT02795221
23 TSH and AMH in Infertile Women Unknown status NCT02710175
24 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487 synacthen
25 Is There Any Association Between Thyroid Cancer and Hashimotos Thyroiditis? Completed NCT01428167
26 Serum Antibodies Against the Insulin-like Growth Factor-1 Receptor (IGF-1R) in Graves' Disease and Graves' Orbitopathy Completed NCT03498417
27 Oxidative Status in Children and Adolescents With Autoimmune Thyroiditis: A Tertiary Center Study From Upper Egypt Completed NCT02318160
28 Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis Completed NCT01884649
29 The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis Completed NCT01760421 Hydroxychloroquine
30 Prevalence of Circulating Parvovirus Genome in Recently Diagnosed Graves' Disease: a Case-control Study Completed NCT02798965
31 Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis Completed NCT03114267
32 Selenium Treatment in Autoimmune Thyroiditis: Long Term Follow-Up With Variable Doses Completed NCT00271427 L-Selenomethionine
33 Differential Diagnosis Value of Peak Systolic Velocity of Thyroid Superior Artery Using Color Flow Doppler Sonography in Transient Thyrotoxicosis Caused by Thyroiditis and Graves Disease Completed NCT01227499
34 Postoperative Hyperthyroidism After Parathyroidectomy Completed NCT01095341
35 Sonographic Characterization of the Thyroid Gland in Patients With Systemic Sclerosis With and Without Hashimoto Thyroiditis Completed NCT01270425
36 Long-term Follow-up After Treatment of Chronic Autoimmune Thyroiditis With Low Level Laser Completed NCT02240563
37 Selenium Supplementation Treatment in Euthyroid Pregnant Women With Autoimmune Thyroid Disease: Effects on Obstetrical Complications Completed NCT01465867
38 Color Flow Doppler Ultrasound in Subclinical Thyroid Dysfunction Completed NCT00437931
39 Clinical Application of Continuous Monitoring Data for the Pulse Rate, Exercise, and Calorie Intake by Wearable Activity Trackers in the Patients With Thyrotoxicosis Completed NCT03009357
40 Retrospective Record Linkage Study to Investigate the Incidence of Complications and Follow-up Associated With Anti-arrythmic Drug Therapy Completed NCT01082055
41 Changes in Thyroid Function Tests and Texture Following Bariatric Surgery Induced Weight Loss Completed NCT03048708
42 Associations of Hematologic Malignancies and Thyroid Cancer With HCV Infection Among US Military Veterans Completed NCT00342641
43 Cervarix Long-term Safety Surveillance Using the PGRx Information System (PGRx Study) Completed NCT01498627
44 Study of the Role of Innate Lymphoid Cells and Natural Killer Cells in Immune Activation of Vitiligo Completed NCT03859518
45 Study of DNA Methylation in Children and Adolescents With Autoimmune Thyroid Diseases Completed NCT02491567
46 Impact of Treating Thyroid Hormone Dysfunction During Pregnancy: A Randomized Controlled Trial of Universal Screening Versus Case Finding Completed NCT00846755 Levothyroxine, Propylthiouracile
47 Autoimmune Thyroid Disease Genetic Study Completed NCT00958113
48 Pilot Study for Evaluation of Glatiramer Acetate in RRMS Patients With Comorbid Autoimmune Conditions Completed NCT01456416
49 Surgical Treatment of Hashimotos Disease. Effect on Antibodies and Clinical Symptoms. Completed NCT02319538
50 Thyroid Disorders in Malaysian: A Nationwide Multicentre Study Completed NCT02190214

Search NIH Clinical Center for Thyroiditis

Cochrane evidence based reviews: thyroiditis

Genetic Tests for Thyroiditis

Anatomical Context for Thyroiditis

MalaCards organs/tissues related to Thyroiditis:

40
Thyroid, T Cells, Pituitary, B Cells, Breast, Testes, Bone

Publications for Thyroiditis

Articles related to Thyroiditis:

(show top 50) (show all 13834)
# Title Authors PMID Year
1
Hepatitis C and interferon induced thyroiditis. 54 61
20022216 2010
2
Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases? 54 61
20464711 2010
3
Painless thyroiditis complicated by acromegaly. 54 61
20075583 2010
4
Dynamic changes of IgG subtypes of thyroid peroxidase antibody in patients with postpartum thyroiditis. 54 61
19829002 2010
5
Interferon induced thyroiditis. 54 61
19942147 2009
6
Expression of CD152 (CTLA-4) in children with autoimmune thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene. 54 61
20134044 2009
7
49A/G and CT60 polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4 gene associated with autoimmune thyroid disease. 54 61
19559744 2009
8
Cytomorphologic study of Hashimoto's thyroiditis and its serologic correlation: a study of 150 cases. 54 61
19798877 2009
9
Different phenotypy in three siblings with homocystinuria. 54 61
19430269 2009
10
Silent thyroiditis, isolated corticotropin deficiency, and alopecia universalis in a patient with ulcerative colitis and elevated levels of plasma factor VIII: an unusual case of autoimmune polyglandular syndrome type 3. 54 61
19289325 2009
11
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma. 54 61
19606248 2009
12
[Thyroid disorders during pregnancy]. 54 61
19142837 2009
13
Evaluation of the role of ultrasonography in diagnosis of autoimmune thyroiditis in goitrous children. 54 61
18451445 2008
14
Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodies. 54 61
18029466 2008
15
A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes. 54 61
18489063 2008
16
Interferon alpha treatment and thyroid dysfunction. 54 61
17983936 2007
17
Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis. 54 61
17887926 2007
18
Obstetric management of thyroid disease. 54 61
17868484 2007
19
[Epidemiologic study of autoimmune thyroid disease in south Tunisia]. 54 61
17194970 2006
20
By-stander activation in autoimmune thyroiditis: studies on experimental autoimmune thyroiditis in the GFP+ fluorescent mouse. 54 61
16916620 2006
21
Circulating level of the platelet-derived CXC chemokine platelet factor 4 in chronic urticaria patients with or without coexistent euthyroid Hashimoto's thyroiditis. 54 61
16891214 2006
22
Clinical and laboratory aspects of thyroid autoantibodies. 54 61
16704751 2006
23
Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease. 54 61
16498048 2006
24
Thyroid hormone increases mannan-binding lectin levels. 54 61
16260422 2005
25
Graves' hyperthyroidism showing transient hypothyroidism during interferon therapy for chronic hepatitis type C. 54 61
16006723 2005
26
Thyroid disorders associated with pregnancy: etiology, diagnosis, and management. 54 61
15649099 2005
27
Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice. 54 61
15320899 2004
28
Inducing Graves' ophthalmopathy. 54 61
15164995 2004
29
[Clinical implications of occurrence of antithyroid antibodies in pregnant women and in the postpartum period]. 54 61
15789919 2004
30
[Subclinical thyroid disease--should we treat, should we screen for it?]. 54 61
15114790 2003
31
Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b. 54 61
14611699 2003
32
Consequences of autoimmune thyroiditis before, during and after pregnancy. 54 61
14605606 2003
33
Interferon-alpha and autoimmune thyroid disease. 54 61
12930598 2003
34
Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen. 54 61
12780686 2003
35
Extrapancreatic autoimmune manifestations in type 1 diabetes patients and their first-degree relatives: a multicenter study. 54 61
12663603 2003
36
Induction of murine thyroiditis by a non dominant E(k)-restricted peptide of human thyroglobulin. 54 61
12667218 2003
37
[Hypothyroidism: clinical and economical implications in a health area]. 54 61
12756897 2003
38
[Interferon-alpha and auto-immunity]. 54 61
12481406 2002
39
Temporal relationship between the appearance of thyroid autoantibodies and development of destructive thyroiditis in patients undergoing treatment with two different type-1 interferons for HCV-related chronic hepatitis: a prospective study. 54 61
12150338 2002
40
[Anti thyroglobulin antibodies in the follow up of patients with differentiated thyroid cancer: residual or relapsing disease markers?]. 54 61
11974529 2002
41
Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. 54 61
11588143 2001
42
Expression of CD40 and apoptosis related molecules in autoimmune thyroid diseases. 54 61
11675676 2001
43
Pregnancy and murine thyroiditis: thyroglobulin immunization leads to fetal loss in specific allogeneic pregnancies. 54 61
11159855 2001
44
Non-MHC driven exacerbation of experimental thyroiditis in the postpartum period. 54 61
11905847 2001
45
Gliadin antibodies in adult insulin-dependent diabetes--autoimmune and immunogenetic correlates. 54 61
11191281 2000
46
Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. 54 61
10634366 2000
47
New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. 54 61
11129116 2000
48
Autoantibodies to thyroglobulin in health and disease. 54 61
10826964 2000
49
Multicenter study on TGPO autoantibody prevalence in various thyroid and non-thyroid diseases; relationships with thyroglobulin and thyroperoxidase autoantibody parameters. 54 61
10601957 1999
50
H2-E transgenic class II-negative mice can distinguish self from nonself in susceptibility to heterologous thyroglobulins in autoimmune thyroiditis. 54 61
10541803 1999

Variations for Thyroiditis

ClinVar genetic disease variations for Thyroiditis:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CEL NM_001807.5(CEL):c.1966G>C (p.Ala656Pro)SNV Uncertain significance 128688 rs587780309 9:135946855-135946855 9:133071468-133071468

Expression for Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for Thyroiditis

GO Terms for Thyroiditis

Cellular components related to Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TSHB TRH TG SERPINA7 PRSS3 INS
2 extracellular space GO:0005615 9.32 TSHB TPO SERPINA7 PRSS3 INS IL2

Biological processes related to Thyroiditis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.88 RET PTPN22 NKX2-1 INS FOXP3
2 B cell differentiation GO:0030183 9.67 TSHR IL10 IFNA1
3 negative regulation of tumor necrosis factor production GO:0032720 9.58 PTPN22 IL10 FOXP3
4 negative regulation of immune response GO:0050777 9.54 FOXP3 CTLA4
5 positive regulation of regulatory T cell differentiation GO:0045591 9.52 IL2 FOXP3
6 hormone biosynthetic process GO:0042446 9.51 TPO TG
7 negative regulation of T cell proliferation GO:0042130 9.5 IL10 FOXP3 CTLA4
8 negative regulation of T-helper 17 cell differentiation GO:2000320 9.46 IL2 FOXP3
9 negative regulation of feeding behavior GO:2000252 9.43 TRH INS
10 thyroid gland development GO:0030878 9.43 THRB TG NKX2-1
11 negative regulation of lymphocyte proliferation GO:0050672 9.37 IL2 FOXP3
12 regulation of regulatory T cell differentiation GO:0045589 9.33 IL2 FOXP3 CTLA4
13 hormone-mediated signaling pathway GO:0009755 9.26 TSHR TSHB TRH THRB
14 cell-cell signaling GO:0007267 9.17 TSHR TSHB TRH INS IL2 FASLG

Molecular functions related to Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 IL2 IL10 IFNA1 FASLG
2 hormone activity GO:0005179 9.02 TSHB TRH TG INS CALCA

Sources for Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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