MCID: THY032
MIFTS: 52

Thyroiditis

Categories: Endocrine diseases, Infectious diseases

Aliases & Classifications for Thyroiditis

MalaCards integrated aliases for Thyroiditis:

Name: Thyroiditis 12 55 6 44 15 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:7166
ICD9CM 35 245 245.9
MeSH 44 D013966
NCIt 50 C26894
SNOMED-CT 68 82119001
ICD10 33 E06 E06.9
UMLS 72 C0040147

Summaries for Thyroiditis

MalaCards based summary : Thyroiditis is related to familial thyroid dyshormonogenesis and thyroid carcinoma, familial medullary. An important gene associated with Thyroiditis is TG (Thyroglobulin), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Allograft rejection. The drugs Prednisone and Celecoxib have been mentioned in the context of this disorder. Affiliated tissues include thyroid, t cells and testes, and related phenotypes are endocrine/exocrine gland and hematopoietic system

Wikipedia : 75 Thyroiditis is the inflammation of the thyroid gland. The thyroid gland is located on the front of the... more...

Related Diseases for Thyroiditis

Diseases in the Thyroiditis family:

Acute Thyroiditis Subacute Thyroiditis

Diseases related to Thyroiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 2700)
# Related Disease Score Top Affiliating Genes
1 familial thyroid dyshormonogenesis 34.9 TPO TG
2 thyroid carcinoma, familial medullary 34.7 TG RET CALCA
3 thyroid sarcoma 34.5 TG CALCA
4 hypothyroidism, congenital, nongoitrous, 2 34.4 TSHR TG SERPINA7
5 suppurative thyroiditis 34.4 TG CALCA
6 acute thyroiditis 34.4 TG CALCA
7 thyroid crisis 34.4 THRB TG SERPINA7
8 subacute thyroiditis 34.4 TSHR TPO TG SERPINA7
9 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 34.3 TPO TG
10 differentiated thyroid carcinoma 34.0 TSHR TPO TG RET
11 generalized resistance to thyroid hormone 33.9 TXNRD2 TRH THRB
12 papillary thyroid microcarcinoma 33.9 TSHR TG CALCA
13 subacute lymphocytic thyroiditis 33.8 TPO TG IL2
14 hashimoto encephalopathy 33.7 TSHR TPO
15 thyroid hormone resistance, generalized, autosomal dominant 33.7 TXNRD2 TRH THRB TG SERPINA7
16 thyroid cancer, nonmedullary, 2 33.6 TSHR TPO THRB TG RET CALCA
17 goiter, multinodular 1, with or without sertoli-leydig cell tumors 33.4 TPO TG
18 congenital hypothyroidism 33.1 TSHR TSHB TPO TG SERPINA7
19 hypothyroidism, congenital, nongoitrous, 4 32.9 TSHB TRH TPO TG SERPINA7
20 hyperthyroidism 32.9 TSHR TRH TPO THRB TG SERPINA7
21 struma ovarii 32.8 TSHR TG RET
22 myxedema 32.7 TSHR TPO TG CTLA4
23 multiple endocrine neoplasia, type iib 32.6 RET CALCA
24 multinodular goiter 32.6 TSHR TPO TG CALCA
25 follicular adenoma 32.4 TSHR TPO TG RET CALCA
26 endemic goiter 32.4 TSHR TSHB TPO TG SERPINA7
27 hyperthyroxinemia 32.1 TSHR TRH TPO SERPINA7
28 plummer's disease 32.1 TPO THRB TG
29 athyreosis 32.0 TSHR TG
30 celiac disease 1 31.8 TPO TG PTPN22 CTLA4
31 graves disease 1 31.8 TXNRD2 TSHR TRH TPO THRB TG
32 hypothyroidism 31.7 TSHR TSHB TRH TPO THRB TG
33 thyroid gland disease 31.6 TXNRD2 TSHR TSHB TRH TPO THRB
34 papillary carcinoma 31.6 TSHR TPO TG RET CALCA
35 goiter 31.5 TXNRD2 TSHR TRH TPO THRB TG
36 endocrine gland cancer 31.4 TG RET CALCA
37 graves' disease 31.3 TSHR TPO TG SERPINA7 PTPN22 FASLG
38 ovarian germ cell teratoma 31.2 TG RET
39 nodular goiter 31.1 TSHR TPO TG RET CALCA
40 nontoxic goiter 31.1 TSHR TPO TG SERPINA7 FASLG CALCA
41 dyshormonogenic goiter 31.1 TG SERPINA7
42 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.1 TSHR TPO TG PTPN22 CTLA4
43 malignant struma ovarii 31.0 TG RET
44 pernicious anemia 31.0 TPO TG
45 fetal adenoma 31.0 TG CALCA
46 postsurgical hypothyroidism 30.9 TSHR TRH TG
47 neonatal thyrotoxicosis 30.8 TXNRD2 TSHR
48 hypoadrenalism 30.5 TG CALCA
49 ovarian germ cell cancer 30.5 TG RET
50 autoimmune disease 30.5 TPO TG PTPN22 IL2 CTLA4

Comorbidity relations with Thyroiditis via Phenotypic Disease Network (PDN):


Hypothyroidism

Graphical network of the top 20 diseases related to Thyroiditis:



Diseases related to Thyroiditis

Symptoms & Phenotypes for Thyroiditis

MGI Mouse Phenotypes related to Thyroiditis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.02 CTLA4 FASLG IL2 PTPN22 RET TG
2 hematopoietic system MP:0005397 9.96 CTLA4 FASLG IL2 PTPN22 RET TG
3 digestive/alimentary MP:0005381 9.91 CTLA4 FASLG IL2 PTPN22 RET TG
4 homeostasis/metabolism MP:0005376 9.9 CTLA4 FASLG IL2 PTPN22 RET TG
5 immune system MP:0005387 9.61 CTLA4 FASLG IL2 PTPN22 RET TG
6 respiratory system MP:0005388 9.1 CTLA4 FASLG IL2 PTPN22 RET THRB

Drugs & Therapeutics for Thyroiditis

Drugs for Thyroiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 124)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
2
Celecoxib Approved, Investigational Phase 4 169590-42-5 2662
3
Xylometazoline Approved, Investigational Phase 4 526-36-3 5709
4
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
5
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
6
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
7
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
8 Orange Approved Phase 4
9
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
10 glucocorticoids Phase 4
11 Peripheral Nervous System Agents Phase 4
12 Prednisolone acetate Phase 4
13 Methylprednisolone Acetate Phase 4
14 Antiemetics Phase 4
15 Gastrointestinal Agents Phase 4
16 Neuroprotective Agents Phase 4
17 Autonomic Agents Phase 4
18
Iodine Approved, Investigational Phase 3 7553-56-2 807
19
Ribavirin Approved Phase 3 36791-04-5 37542
20
Propylthiouracil Approved, Investigational Phase 3 51-52-5 657298
21
tannic acid Approved Phase 3 1401-55-4
22
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
23
Carbimazole Approved, Investigational Phase 3 22232-54-8 31072
24 Immunologic Factors Phase 3
25 Anti-Infective Agents Phase 3
26 Micronutrients Phase 3
27 Nutrients Phase 3
28 Trace Elements Phase 3
29 cadexomer iodine Phase 3
30 Anti-Infective Agents, Local Phase 3
31 Interferon alpha-2 Phase 3
32 Interferon-alpha Phase 3
33 interferons Phase 3
34 Antiviral Agents Phase 3
35 Antimetabolites Phase 3
36 Antithyroid Agents Phase 3
37
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
38
Methimazole Approved Phase 2 60-56-0 1349907
39
rituximab Approved Phase 1, Phase 2 174722-31-7 10201696
40
Hydroxychloroquine Approved Phase 2 118-42-3 3652
41
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
42
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
43
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
44
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
45
Pidilizumab Investigational Phase 1, Phase 2 1036730-42-3
46 Immunosuppressive Agents Phase 1, Phase 2
47 Alkylating Agents Phase 1, Phase 2
48 Antineoplastic Agents, Alkylating Phase 1, Phase 2
49 Antineoplastic Agents, Immunological Phase 1, Phase 2
50 Immunoglobulin G Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 75)
# Name Status NCT ID Phase Drugs
1 L-selenomethionine Supplementation in Children and Adolescents With Autoimmune Thyroiditis: a Randomized Blind Placebo-controlled Clinical Trial Unknown status NCT02644707 Phase 4
2 Efficiency and Safety Study of Short-term Prednisone to Treat Moderate and Severe Subacute Thyroiditis Completed NCT01837433 Phase 4 Prednisone 1 week;Prednisone 6 weeks
3 Safety and Efficacy of Oral Mega Pulse Methylprednisolone in Severe Therapy Resistant Alopecia Areata Completed NCT01167946 Phase 4 methylprednisolone sodium succinate;methylprednisolone sodium succinate;methylprednisolone sodium succinate
4 Pilot Double-Blind Placebo Controlled Trial of Levothyroxine in Pregnant Systemic Lupus Erythematosus (SLE) Patients With Autoimmune Thyroid Disease Withdrawn NCT01276782 Phase 4 Levothyroxine
5 An Open Labelled, Active Controlled, Three Arm, Parallel- Group Study of the Safety and Efficacy of Renessans Administered Alone and in Combination With Standard Interferon Therapy in Patients Chronic HCV Hepatitis Unknown status NCT01463592 Phase 3 Interferon Alfa-2b AND RIBAVIRIN
6 A Randomised Study of Two Anti-thyroid Drug Treatment Regimens in Young People Completed NCT01436994 Phase 3 carbimazole;propylthiouracil;thyroxine
7 Effect of Supplementation of Two Doses of L-selenomethionine (Semet; 80 and 160 mcg) Versus Placebo in Patients With Chronic Autoimmune Thyroiditis (AIT) With Normal Thyroid Function. Unknown status NCT02302768 Phase 2
8 A Phase I/ II Clinical Trial of MDV9300 (Pidilizumab) in Diffuse Intrinsic Pontine Glioma Unknown status NCT01952769 Phase 1, Phase 2
9 A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Trial to Evaluate the Safety and Potential Effects of the Dietary Supplement Anatabloc on Antithyroid Autoantibodies and Thyroid Function in Autoimmune Thyroiditis Completed NCT01551498 Phase 2
10 Low-Level Laser Therapy in Chronic Autoimmune Thyroiditis: Randomized, Placebo Controlled Clinical Trial Completed NCT01129492 Phase 2
11 Rituximab (RTX) for IgG4-related Disease (IgG4-RD): a Prospective,Open-label Trial Completed NCT01584388 Phase 1, Phase 2 Rituximab
12 A Pilot Study of the Role of Methimazole in Patients With Polymyositis and Dermatomyositis Completed NCT00001421 Phase 2 methimazole
13 The Role of Immunomodulatory Treatment in Success of ICSI in Patients Who Have Infertility With Autoimmune Thyroiditis Recruiting NCT03289403 Phase 2 Immunomodulatory;Thyroxine
14 Treatment of IgG4-Related Disease With Revlimid and Rituximab: The TIGR2 Trial Completed NCT02705638 Phase 1 Rituximab;Lenalidomide
15 Phase 1 Single-Dose Study of the Pharmacokinetics of Sustained-Release Liothyronine Sodium (T3) in Healthy Subjects Completed NCT01581463 Phase 1 Liothyronine, Sodium
16 CXCL9 and CXCL11 Levels in Patients With Autoimmune Thyroiditis and Habitual Abortions Unknown status NCT01644318
17 Association of Serum Fibroblast Growth Factor 21 (FGF-21) Levels With Resting Metabolic Rate (RMR), in Children and Adolescents With Hashimoto's Thyroiditis. Unknown status NCT02725879
18 The Effect of Plaquenil on Serum Inflammatory Markers and Goiter in Euthyroid Young Women With Hashimoto's Thyroiditis Unknown status NCT02126683 Hydroxychloroquine
19 The Association of Costimulatory Molecules and PPAR-polymorphisms With Autoimmune Thyroid Disease in Taiwan Unknown status NCT01260532
20 Study of DNA Methylation in Children and Adolescents With Autoimmune Thyroid Diseases Unknown status NCT02491567
21 Autoantibodies in Patients With Type 1 Diabetes Mellitus Unknown status NCT00173628
22 Observative and Community Study, Using Nailfold Video-capillaroscopy in Order to Assess the Prevalence of Pathological Changes in the Capillaries in First Grade Family Members of Patient Diagnosed With Systemic Sclerosis Unknown status NCT02795221
23 TSH and AMH in Infertile Women Unknown status NCT02710175
24 Isolated ACTH Deficiency in Patients With Hashimoto Thyroiditis Completed NCT00552487 synacthen
25 Is There Any Association Between Thyroid Cancer and Hashimotos Thyroiditis? Completed NCT01428167
26 Serum Antibodies Against the Insulin-like Growth Factor-1 Receptor (IGF-1R) in Graves' Disease and Graves' Orbitopathy Completed NCT03498417
27 Oxidative Status in Children and Adolescents With Autoimmune Thyroiditis: A Tertiary Center Study From Upper Egypt Completed NCT02318160
28 Fetuin A as a New Marker of Inflammation in Hashimoto Thyroiditis Completed NCT01884649
29 The Effect of Hydroxychloroquine Treatment in Hashimoto's Thyroiditis Completed NCT01760421 Hydroxychloroquine
30 Prevalence of Circulating Parvovirus Genome in Recently Diagnosed Graves' Disease: a Case-control Study Completed NCT02798965
31 Involvement of Viral Infections in the Pathogenesis of Chronic Lymphocytic Thyroiditis Completed NCT03114267
32 Selenium Treatment in Autoimmune Thyroiditis: Long Term Follow-Up With Variable Doses Completed NCT00271427 L-Selenomethionine
33 Differential Diagnosis Value of Peak Systolic Velocity of Thyroid Superior Artery Using Color Flow Doppler Sonography in Transient Thyrotoxicosis Caused by Thyroiditis and Graves Disease Completed NCT01227499
34 Postoperative Hyperthyroidism After Parathyroidectomy Completed NCT01095341
35 Sonographic Characterization of the Thyroid Gland in Patients With Systemic Sclerosis With and Without Hashimoto Thyroiditis Completed NCT01270425
36 Long-term Follow-up After Treatment of Chronic Autoimmune Thyroiditis With Low Level Laser Completed NCT02240563
37 Selenium Supplementation Treatment in Euthyroid Pregnant Women With Autoimmune Thyroid Disease: Effects on Obstetrical Complications Completed NCT01465867
38 Clinical Application of Continuous Monitoring Data for the Pulse Rate, Exercise, and Calorie Intake by Wearable Activity Trackers in the Patients With Thyrotoxicosis Completed NCT03009357
39 Retrospective Record Linkage Study to Investigate the Incidence of Complications and Follow-up Associated With Anti-arrythmic Drug Therapy Completed NCT01082055
40 Color Flow Doppler Ultrasound in Subclinical Thyroid Dysfunction Completed NCT00437931
41 Changes in Thyroid Function Tests and Texture Following Bariatric Surgery Induced Weight Loss Completed NCT03048708
42 Associations of Hematologic Malignancies and Thyroid Cancer With HCV Infection Among US Military Veterans Completed NCT00342641
43 Cervarix Long-term Safety Surveillance Using the PGRx Information System (PGRx Study) Completed NCT01498627
44 Impact of Treating Thyroid Hormone Dysfunction During Pregnancy: A Randomized Controlled Trial of Universal Screening Versus Case Finding Completed NCT00846755 Levothyroxine, Propylthiouracile
45 Autoimmune Thyroid Disease Genetic Study Completed NCT00958113
46 Pilot Study for Evaluation of Glatiramer Acetate in RRMS Patients With Comorbid Autoimmune Conditions Completed NCT01456416
47 Thyroid Disorders in Malaysian: A Nationwide Multicentre Study Completed NCT02190214
48 Surgical Treatment of Hashimotos Disease. Effect on Antibodies and Clinical Symptoms. Completed NCT02319538
49 T and B Cells Infiltrating Orbital Tissues in Graves' Orbitopathy (GO) and Their Relation With GO Features Completed NCT03195296
50 Gluten-related Disorders in Patients Affected With Familial Mediterranean Fever Completed NCT03563300

Search NIH Clinical Center for Thyroiditis

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Hydrocortisone acetate
Prednisone

Cochrane evidence based reviews: thyroiditis

Genetic Tests for Thyroiditis

Anatomical Context for Thyroiditis

MalaCards organs/tissues related to Thyroiditis:

41
Thyroid, T Cells, Testes, B Cells, Lymph Node, Pituitary, Breast

Publications for Thyroiditis

Articles related to Thyroiditis:

(show top 50) (show all 13572)
# Title Authors PMID Year
1
Hepatitis C and interferon induced thyroiditis. 9 38
20022216 2010
2
Pathogenesis of thyroid eye disease--does autoimmunity against the TSH receptor explain all cases? 9 38
20464711 2010
3
Painless thyroiditis complicated by acromegaly. 9 38
20075583 2010
4
Dynamic changes of IgG subtypes of thyroid peroxidase antibody in patients with postpartum thyroiditis. 9 38
19829002 2010
5
Interferon induced thyroiditis. 9 38
19942147 2009
6
Expression of CD152 (CTLA-4) in children with autoimmune thyroiditis and +49 A/G polymorphism of exon 1 of the CTLA-4 gene. 9 38
20134044 2009
7
49A/G and CT60 polymorphisms of the cytotoxic T-lymphocyte-associated antigen 4 gene associated with autoimmune thyroid disease. 9 38
19559744 2009
8
Cytomorphologic study of Hashimoto's thyroiditis and its serologic correlation: a study of 150 cases. 9 38
19798877 2009
9
Different phenotypy in three siblings with homocystinuria. 9 38
19430269 2009
10
Silent thyroiditis, isolated corticotropin deficiency, and alopecia universalis in a patient with ulcerative colitis and elevated levels of plasma factor VIII: an unusual case of autoimmune polyglandular syndrome type 3. 9 38
19289325 2009
11
[Thyroid disorders during pregnancy]. 9 38
19142837 2009
12
Hypercalcitoninemia is not pathognomonic of medullary thyroid carcinoma. 9 38
19606248 2009
13
Evaluation of the role of ultrasonography in diagnosis of autoimmune thyroiditis in goitrous children. 9 38
18451445 2008
14
Characterization of thyroglobulin epitopes in patients with autoimmune and non-autoimmune thyroid diseases using recombinant human monoclonal thyroglobulin autoantibodies. 9 38
18029466 2008
15
A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes. 9 38
18489063 2008
16
Interferon alpha treatment and thyroid dysfunction. 9 38
17983936 2007
17
Eye signs and serum eye muscle and collagen XIII antibodies in patients with transient and progressive thyroiditis. 9 38
17887926 2007
18
Obstetric management of thyroid disease. 9 38
17868484 2007
19
[Epidemiologic study of autoimmune thyroid disease in south Tunisia]. 9 38
17194970 2006
20
By-stander activation in autoimmune thyroiditis: studies on experimental autoimmune thyroiditis in the GFP+ fluorescent mouse. 9 38
16916620 2006
21
Circulating level of the platelet-derived CXC chemokine platelet factor 4 in chronic urticaria patients with or without coexistent euthyroid Hashimoto's thyroiditis. 9 38
16891214 2006
22
Clinical and laboratory aspects of thyroid autoantibodies. 9 38
16704751 2006
23
Interferon-alpha-induced hyperthyroidism: a three-stage evolution from silent thyroiditis towards Graves' disease. 9 38
16498048 2006
24
Thyroid hormone increases mannan-binding lectin levels. 9 38
16260422 2005
25
Graves' hyperthyroidism showing transient hypothyroidism during interferon therapy for chronic hepatitis type C. 9 38
16006723 2005
26
Thyroid disorders associated with pregnancy: etiology, diagnosis, and management. 9 38
15649099 2005
27
Superiority of thyroid peroxidase DNA over protein immunization in replicating human thyroid autoimmunity in HLA-DRB1*0301 (DR3) transgenic mice. 9 38
15320899 2004
28
Inducing Graves' ophthalmopathy. 9 38
15164995 2004
29
[Clinical implications of occurrence of antithyroid antibodies in pregnant women and in the postpartum period]. 9 38
15789919 2004
30
[Subclinical thyroid disease--should we treat, should we screen for it?]. 9 38
15114790 2003
31
Thyrotropin receptor-DNA vaccination of transgenic mice expressing HLA-DR3 or HLA-DQ6b. 9 38
14611699 2003
32
Consequences of autoimmune thyroiditis before, during and after pregnancy. 9 38
14605606 2003
33
Interferon-alpha and autoimmune thyroid disease. 9 38
12930598 2003
34
Insight into antibody responses induced by plasmid or adenoviral vectors encoding thyroid peroxidase, a major thyroid autoantigen. 9 38
12780686 2003
35
Induction of murine thyroiditis by a non dominant E(k)-restricted peptide of human thyroglobulin. 9 38
12667218 2003
36
Extrapancreatic autoimmune manifestations in type 1 diabetes patients and their first-degree relatives: a multicenter study. 9 38
12663603 2003
37
[Hypothyroidism: clinical and economical implications in a health area]. 9 38
12756897 2003
38
[Interferon-alpha and auto-immunity]. 9 38
12481406 2002
39
Temporal relationship between the appearance of thyroid autoantibodies and development of destructive thyroiditis in patients undergoing treatment with two different type-1 interferons for HCV-related chronic hepatitis: a prospective study. 9 38
12150338 2002
40
[Anti thyroglobulin antibodies in the follow up of patients with differentiated thyroid cancer: residual or relapsing disease markers?]. 9 38
11974529 2002
41
Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. 9 38
11588143 2001
42
Expression of CD40 and apoptosis related molecules in autoimmune thyroid diseases. 9 38
11675676 2001
43
Pregnancy and murine thyroiditis: thyroglobulin immunization leads to fetal loss in specific allogeneic pregnancies. 9 38
11159855 2001
44
Non-MHC driven exacerbation of experimental thyroiditis in the postpartum period. 9 38
11905847 2001
45
Gliadin antibodies in adult insulin-dependent diabetes--autoimmune and immunogenetic correlates. 9 38
11191281 2000
46
Postpartum thyroiditis and long-term thyroid status: prognostic influence of thyroid peroxidase antibodies and ultrasound echogenicity. 9 38
10634366 2000
47
New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models. 9 38
11129116 2000
48
Autoantibodies to thyroglobulin in health and disease. 9 38
10826964 2000
49
Multicenter study on TGPO autoantibody prevalence in various thyroid and non-thyroid diseases; relationships with thyroglobulin and thyroperoxidase autoantibody parameters. 9 38
10601957 1999
50
[Increased serum soluble Fas ligand in hyperthyroid Graves' disease]. 9 38
10590671 1999

Variations for Thyroiditis

ClinVar genetic disease variations for Thyroiditis:

6
# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 CEL NM_001807.5(CEL): c.1966G> C (p.Ala656Pro) single nucleotide variant Uncertain significance rs587780309 9:135946855-135946855 9:133071468-133071468

Expression for Thyroiditis

Search GEO for disease gene expression data for Thyroiditis.

Pathways for Thyroiditis

GO Terms for Thyroiditis

Cellular components related to Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 TSHB TPO SERPINA7 PRSS3 IL2 FASLG
2 extracellular region GO:0005576 9.23 TSHB TRH TG SERPINA7 PRSS3 IL2

Biological processes related to Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid gland development GO:0030878 9.37 THRB TG
2 regulation of regulatory T cell differentiation GO:0045589 9.26 IL2 CTLA4
3 hormone-mediated signaling pathway GO:0009755 9.26 TSHR TSHB TRH THRB
4 hormone biosynthetic process GO:0042446 9.16 TPO TG
5 cell-cell signaling GO:0007267 9.1 TSHR TSHB TRH IL2 FASLG CALCA
6 response to pain GO:0048265 9.02 RET

Molecular functions related to Thyroiditis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 TSHB TRH TG CALCA

Sources for Thyroiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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