MCID: THY013
MIFTS: 25

Thyrotoxic Exophthalmos

Categories: Eye diseases

Aliases & Classifications for Thyrotoxic Exophthalmos

MalaCards integrated aliases for Thyrotoxic Exophthalmos:

Name: Thyrotoxic Exophthalmos 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:12362
ICD9CM 34 376.21
SNOMED-CT 67 19885005
UMLS 71 C0155265

Summaries for Thyrotoxic Exophthalmos

MalaCards based summary : Thyrotoxic Exophthalmos is related to exophthalmos and decubitus ulcer. An important gene associated with Thyrotoxic Exophthalmos is SHANK2 (SH3 And Multiple Ankyrin Repeat Domains 2), and among its related pathways/superpathways are Photodynamic therapy-induced NF-kB survival signaling and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include eye and thyroid, and related phenotypes are integument and nervous system

Wikipedia : 74 Graves ophthalmopathy,also known as thyroid eye disease (TED), is an autoimmune inflammatory disorder of... more...

Related Diseases for Thyrotoxic Exophthalmos

Diseases related to Thyrotoxic Exophthalmos via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 exophthalmos 10.6
2 decubitus ulcer 10.1 SHANK2 IL6
3 ovarian squamous cell carcinoma 10.1 CCND1 APOLD1
4 eye lymphoma 10.1 IL6 CD5
5 myasthenia gravis 10.1
6 kearns-sayre syndrome 10.1
7 optic neuritis 10.1
8 neuritis 10.1
9 myopathy 10.1
10 mixed lacrimal gland cancer 10.1 IL6 CCND1
11 intussusception 10.1 IL6 APOLD1
12 alpha chain disease 10.1 CD5 CCND1
13 diverticulitis 10.0 IL6 APOLD1
14 spindle epithelial tumor with thymus-like differentiation tumor 10.0 TG CD5
15 anus disease 10.0 IL6 APOLD1
16 papillary thymic adenocarcinoma 10.0 TG CD5
17 epithelial malignant thymoma 10.0 TG CD5
18 autoimmune disease of blood 10.0 IL6 CD5
19 extramedullary plasmacytoma 10.0 IL6 CCND1
20 ectopic thymus 10.0 TG CD5
21 rectal disease 10.0 IL6 APOLD1
22 lymphoepithelioma-like thymic carcinoma 10.0 TG CD5
23 monoclonal gammopathy of uncertain significance 9.9 IL6 CCND1
24 euthyroid sick syndrome 9.9 TG IL6
25 vein disease 9.9 IL6 APOLD1
26 cryoglobulinemia 9.9 IL6 CD5
27 subacute thyroiditis 9.9 TG IL6
28 bladder lymphoma 9.9 MME CD5
29 prostate lymphoma 9.9 MME CD5
30 fallopian tube endometrioid adenocarcinoma 9.9 MME APOLD1
31 liver lymphoma 9.9 MME CD5
32 bone lymphoma 9.9 MME CD5
33 colon lymphoma 9.9 MME CD5
34 intravascular large b-cell lymphoma 9.9 MME CD5
35 lung lymphoma 9.9 MME CD5
36 nodular goiter 9.9 TG IL6
37 breast lymphoma 9.9 MME CD5
38 sclerosing hepatic carcinoma 9.9 MME CD5
39 composite lymphoma 9.9 MME CD5
40 adult lymphoma 9.9 MME CD5
41 tracheal lymphoma 9.9 MME CD5
42 colonic benign neoplasm 9.9 IL6 CCND1
43 spinal cord lymphoma 9.8 MME CD5
44 breast osteosarcoma 9.8 MME CD5
45 nodal marginal zone lymphoma 9.8 MME CD5
46 autoimmune disease of endocrine system 9.8 TG IL6
47 central nervous system hematologic cancer 9.8 MME CD5
48 prolymphocytic leukemia 9.8 CD5 CCND1
49 polyclonal hypergammaglobulinemia 9.8 MME IL6
50 intestinal obstruction 9.8 IL6 APOLD1

Comorbidity relations with Thyrotoxic Exophthalmos via Phenotypic Disease Network (PDN):


Hypothyroidism

Graphical network of the top 20 diseases related to Thyrotoxic Exophthalmos:



Diseases related to Thyrotoxic Exophthalmos

Symptoms & Phenotypes for Thyrotoxic Exophthalmos

MGI Mouse Phenotypes related to Thyrotoxic Exophthalmos:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.43 CCND1 CD5 IL6 MME SLC7A11 TG
2 nervous system MP:0003631 9.17 CCND1 CD5 IL6 MME SHANK2 SLC7A11

Drugs & Therapeutics for Thyrotoxic Exophthalmos

Search Clinical Trials , NIH Clinical Center for Thyrotoxic Exophthalmos

Genetic Tests for Thyrotoxic Exophthalmos

Anatomical Context for Thyrotoxic Exophthalmos

MalaCards organs/tissues related to Thyrotoxic Exophthalmos:

40
Eye, Thyroid

Publications for Thyrotoxic Exophthalmos

Articles related to Thyrotoxic Exophthalmos:

# Title Authors PMID Year
1
[Clinical observation on treatment of thyrotoxic exophthalmos with jiayanxiao plus tapazole]. 61
11789227 2000
2
Thyrotoxic exophthalmos. 61
1852838 1991
3
Surgical treatment of thyrotoxic exophthalmos. 61
2385687 1990
4
Surgical treatment of thyrotoxic exophthalmos. 61
2256996 1990
5
Thyrotoxic exophthalmos. 61
2359797 1990
6
Surgical treatment of thyrotoxic exophthalmos. 61
2813584 1989
7
[Effect of Chinese drugs or the combination of Chinese and western drugs in the treatment of thyrotoxic exophthalmos]. 61
6237772 1984
8
[The surgical treatment of thyrotoxic exophthalmos using Ogura's operation (author's transl)]. 61
582501 1979
9
Thyrotoxic exophthalmos with ophthalmoplegia and ocular myasthenia gravis. 61
5891299 1965
10
Thyrotoxic exophthalmos with myopathy. 61
18135020 1949

Variations for Thyrotoxic Exophthalmos

Expression for Thyrotoxic Exophthalmos

Search GEO for disease gene expression data for Thyrotoxic Exophthalmos.

Pathways for Thyrotoxic Exophthalmos

Pathways related to Thyrotoxic Exophthalmos according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.26 IL6 CCND1
2 11.2 MME IL6 CD5
3 11.17 IL6 CCND1
4 11.13 MME CD5
5 11.08 IL6 CCND1
6 11.03 IL6 CCND1
7 10.8 IL6 CCND1
8 10.79 MME IL6 CD5
9 10.69 IL6 CCND1

GO Terms for Thyrotoxic Exophthalmos

Cellular components related to Thyrotoxic Exophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 brush border membrane GO:0031526 8.62 SLC7A11 SHANK2

Biological processes related to Thyrotoxic Exophthalmos according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to glucocorticoid GO:0051384 8.96 IL6 CCND1
2 adult behavior GO:0030534 8.62 SLC7A11 SHANK2

Sources for Thyrotoxic Exophthalmos

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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