MCID: THY054
MIFTS: 46

Thyrotoxic Periodic Paralysis

Categories: Endocrine diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Thyrotoxic Periodic Paralysis

MalaCards integrated aliases for Thyrotoxic Periodic Paralysis:

Name: Thyrotoxic Periodic Paralysis 52 58 39 71
Thyrotoxic Hypokalemic Periodic Paralysis 58

Characteristics:

Orphanet epidemiological data:

58
thyrotoxic periodic paralysis
Inheritance: Multigenic/multifactorial,Not applicable; Age of onset: Adult; Age of death: normal life expectancy;

Classifications:

Orphanet: 58  
Rare neurological diseases


Summaries for Thyrotoxic Periodic Paralysis

NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 79102 Definition Thyrotoxic periodic paralysis (TPP) is a rare neurological disease characterized by recurrent episodes of paralysis and hypokalemia during a thyrotoxic state. Epidemiology It is most common in Asian males (with male-to-female ratios ranging from 17:1 to 70:1) during the third decade of life: the annual incidence in Chinese and Japanese thyrotoxicosis patients is estimated at around 1/50, whereas it is estimated at 1-2/1,000 among non-Asian thyrotoxicosis patients. Clinical description TPP manifests as recurrent episodes of acute muscular weakness of the four extremities that vary in severity from paresis to complete paralysis. Recovery occurs within 2-72 hours. Attacks typically occur at night and may be preceded by muscle cramps, aches and stiffness. Ocular, bulbar and respiratory involvement has also been reported but is rare. Attacks are triggered by ingestion of a high carbohydrate load or strenuous physical activity followed by a period of rest. Episodes only occur when patients are thyrotoxic but symptoms and classical signs of hyperthyroidism are often absent at the time of the first attack. TPP can occur in association with any cause of hyperthyroidism, but is most commonly associated with Graves' disease. Etiology The pathogenesis remains unclear. Genetic predisposition is thought to play a role in the pathogenesis of TPP and single nucleotide polymorphisms (SNPs) of the CACNA1S (1q32) and GABRA3 (Xq28) genes have been associated with TPP susceptibility in some Asian populations. Hypokalemia is the consequence of an extra- to intracellular potassium shift due to an increase in Na/K-ATPase pump activity, either as a direct response to thyroid hormone or indirectly via adrenergic stimulation, insulin or exercise. Diagnostic methods Biochemical studies are essential for diagnosis, with mild-to-severe thyrotoxicosis and hypokalemia during attacks being the major findings. Other anomalies may include hypophosphatemia and hypomagnesemia, without changes in acid-base balance. EMG reveals myopathic changes during attacks and muscle excitability anomalies after a prolonged exercise test. ECG anomalies are also noted. Thyrotoxicosis is the key finding for distinguishing TPP from other causes of hypokalemic periodic paralysis (HOP), such as familial HOP (FHOP; see this term), and from other hypokalemic disorders with a transcellular potassium shift, and excessive renal potassium wasting or gastrointestinal losses. Differential diagnosis The differential diagnosis may also include Guillain-Barre syndrome , transverse myelitis (see these terms), spinal cord compression and hysteria, as well as muscle weakness and fatigue associated with hyperthyroidism in patients with thyrotoxic myopathy or myasthenia gravis (see this term). Genetic counseling TPP usually occurs sporadically Management and treatment Management of TPP includes definitive control of hyperthyroidism, prevention of attacks with propranolol and avoidance of precipitating factors. Potassium administration during attacks may prevent cardiac arrhythmias and hasten the recovery from paralysis. Prognosis The prognosis for patients is good and TPP resolves when euthyroid status is achieved. Visit the Orphanet disease page for more resources.

MalaCards based summary : Thyrotoxic Periodic Paralysis, also known as thyrotoxic hypokalemic periodic paralysis, is related to thyrotoxic periodic paralysis 1 and periodic paralysis. An important gene associated with Thyrotoxic Periodic Paralysis is KCNJ18 (Potassium Inwardly Rectifying Channel Subfamily J Member 18), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Cardiac conduction. The drugs Immunoglobulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and heart, and related phenotypes are periodic hypokalemic paresis and episodic hypokalemia

Wikipedia : 74 Thyrotoxic periodic paralysis (TPP) is a condition featuring attacks of muscle weakness in the presence... more...

Related Diseases for Thyrotoxic Periodic Paralysis

Diseases in the Thyrotoxic Periodic Paralysis family:

Thyrotoxic Periodic Paralysis 1 Thyrotoxic Periodic Paralysis 2
Thyrotoxic Periodic Paralysis 3

Diseases related to Thyrotoxic Periodic Paralysis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 thyrotoxic periodic paralysis 1 34.9 KCNJ18 CACNA1S
2 periodic paralysis 31.7 KCNJ2 KCNJ18 CACNA1S ATP1A2
3 hypokalemia 31.6 KCNJ18 CACNA1S ADRB2
4 hypokalemic periodic paralysis, type 1 31.3 KCNJ2 KCNJ18 CACNA1S
5 graves disease 1 31.0 TSHR KCNJ18 CACNA1S
6 hyperthyroidism 31.0 TSHR KCNJ18 CACNA1S
7 familial periodic paralysis 30.8 KCNJ2 KCNJ18 CACNA1S
8 periodic paralyses 30.4 KCNJ2 CACNA1S
9 andersen cardiodysrhythmic periodic paralysis 30.2 KCNJ2 KCNJ18 CACNA1S
10 thyrotoxic periodic paralysis 2 13.1
11 thyrotoxic periodic paralysis 3 12.8
12 graves' disease 10.9
13 goiter 10.6
14 respiratory failure 10.6
15 quadriplegia 10.5
16 hypophosphatemia 10.5
17 thyroiditis 10.5
18 familial periodic paralyses 10.5
19 myopathy 10.4
20 atrioventricular block 10.4
21 ventricular fibrillation, paroxysmal familial, 1 10.4
22 multinodular goiter 10.4
23 cardiac arrest 10.4
24 adenoma 10.4
25 47,xyy 10.3
26 tremor 10.3
27 stroke, ischemic 10.2
28 branchiootic syndrome 1 10.2
29 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
30 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
31 transient cerebral ischemia 10.2
32 papillary carcinoma 10.2
33 pathologic nystagmus 10.2
34 myotonia congenita 10.2 KCNJ2 CACNA1S
35 first-degree atrioventricular block 10.2
36 glucose intolerance 10.2
37 hypothyroidism 10.2
38 hepatitis c 10.2
39 hyperinsulinism 10.2
40 pituitary adenoma 10.2
41 adrenal adenoma 10.2
42 subacute thyroiditis 10.2
43 exophthalmos 10.2
44 myopathy - thyrotoxic 10.2
45 spinocerebellar ataxia 6 10.1 CACNA1S ATP1A2
46 hyperkalemic periodic paralysis 10.1 KCNJ2 KCNJ18 CACNA1S
47 atrial standstill 1 10.1
48 progressive familial heart block, type ia 10.1
49 hypertelorism 10.1
50 lipoid congenital adrenal hyperplasia 10.1

Graphical network of the top 20 diseases related to Thyrotoxic Periodic Paralysis:



Diseases related to Thyrotoxic Periodic Paralysis

Symptoms & Phenotypes for Thyrotoxic Periodic Paralysis

Human phenotypes related to Thyrotoxic Periodic Paralysis:

58 31 (show all 44)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 periodic hypokalemic paresis 58 31 obligate (100%) Obligate (100%) HP:0008153
2 episodic hypokalemia 58 31 obligate (100%) Obligate (100%) HP:0012726
3 hyperhidrosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000975
4 emg abnormality 58 31 hallmark (90%) Very frequent (99-80%) HP:0003457
5 obesity 58 31 hallmark (90%) Very frequent (99-80%) HP:0001513
6 episodic flaccid weakness 58 31 hallmark (90%) Very frequent (99-80%) HP:0003752
7 tetraplegia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002445
8 graves disease 58 31 hallmark (90%) Very frequent (99-80%) HP:0100647
9 hypomagnesemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0002917
10 lower limb muscle weakness 58 31 hallmark (90%) Very frequent (99-80%) HP:0007340
11 increased intramyocellular lipid droplets 58 31 hallmark (90%) Very frequent (99-80%) HP:0012240
12 palpitations 58 31 hallmark (90%) Very frequent (99-80%) HP:0001962
13 transient hypophosphatemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0008285
14 thyrotoxicosis with toxic single thyroid nodule 58 31 hallmark (90%) Very frequent (99-80%) HP:0011786
15 decreased urinary potassium 58 31 hallmark (90%) Very frequent (99-80%) HP:0012364
16 mildly elevated creatine kinase 31 hallmark (90%) HP:0008180
17 thyrotoxicosis with toxic multinodular goiter 31 hallmark (90%) HP:0011785
18 weight loss 58 31 frequent (33%) Frequent (79-30%) HP:0001824
19 tremor 58 31 frequent (33%) Frequent (79-30%) HP:0001337
20 muscle stiffness 58 31 frequent (33%) Frequent (79-30%) HP:0003552
21 constipation 58 31 frequent (33%) Frequent (79-30%) HP:0002019
22 hyporeflexia 58 31 frequent (33%) Frequent (79-30%) HP:0001265
23 muscle spasm 58 31 frequent (33%) Frequent (79-30%) HP:0003394
24 urinary retention 58 31 frequent (33%) Frequent (79-30%) HP:0000016
25 exercise-induced muscle fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0009020
26 postprandial hyperglycemia 58 31 frequent (33%) Frequent (79-30%) HP:0011998
27 rhabdomyolysis 58 31 frequent (33%) Frequent (79-30%) HP:0003201
28 prolonged qt interval 58 31 occasional (7.5%) Occasional (29-5%) HP:0001657
29 late-onset proximal muscle weakness 58 31 occasional (7.5%) Occasional (29-5%) HP:0003694
30 ventricular fibrillation 58 31 occasional (7.5%) Occasional (29-5%) HP:0001663
31 shortened pr interval 58 31 occasional (7.5%) Occasional (29-5%) HP:0005165
32 second degree atrioventricular block 58 31 occasional (7.5%) Occasional (29-5%) HP:0011706
33 ophthalmoparesis 58 31 very rare (1%) Very rare (<4-1%) HP:0000597
34 hyperkalemia 58 31 very rare (1%) Very rare (<4-1%) HP:0002153
35 respiratory paralysis 58 31 very rare (1%) Very rare (<4-1%) HP:0002203
36 abnormality of peripheral nerve conduction 58 Excluded (0%)
37 myotonia 58 Excluded (0%)
38 hyperthyroidism 58 Obligate (100%)
39 mildly elevated creatine phosphokinase 58 Very frequent (99-80%)
40 paralysis 58 Very frequent (99-80%)
41 abnormality of muscle fibers 58 Very frequent (99-80%)
42 impaired myocardial contractility 58 Excluded (0%)
43 thyrotoxicosis with diffuse goiter 58 Very frequent (99-80%)
44 thyrotoxicosis with toxic multinodular goitre 58 Very frequent (99-80%)

MGI Mouse Phenotypes related to Thyrotoxic Periodic Paralysis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 muscle MP:0005369 9.1 ADRB2 ATP1A1 ATP1A2 ATP1B1 CACNA1S KCNJ2

Drugs & Therapeutics for Thyrotoxic Periodic Paralysis

Drugs for Thyrotoxic Periodic Paralysis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulins
2 Antibodies

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Genetic and Morphological Analysis of Thyrotoxic Periodic Paralysis:an Observational Study of Sichuan Individuals in China. Unknown status NCT02287363
2 Genetic Analysis of Thai Patients With Thyrotoxic Periodic Paralysis Completed NCT00443833

Search NIH Clinical Center for Thyrotoxic Periodic Paralysis

Genetic Tests for Thyrotoxic Periodic Paralysis

Anatomical Context for Thyrotoxic Periodic Paralysis

MalaCards organs/tissues related to Thyrotoxic Periodic Paralysis:

40
Thyroid, Testes, Heart, Spinal Cord, Pituitary, Skeletal Muscle, Colon

Publications for Thyrotoxic Periodic Paralysis

Articles related to Thyrotoxic Periodic Paralysis:

(show top 50) (show all 483)
# Title Authors PMID Year
1
Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypokalemic periodic paralysis. 61 6
20074522 2010
2
Association of novel single nucleotide polymorphisms in the calcium channel alpha 1 subunit gene (Ca(v)1.1) and thyrotoxic periodic paralysis. 61 6
15001631 2004
3
Sudden Night Palsy in a Young Man: Thyrotoxic Periodic Paralysis as a First Manifestation of Hyperthyroidism. 61
31862328 2020
4
Further evidence for shared genetic susceptibility in both sporadic and Thyrotoxic periodic paralysis. 61
32229026 2020
5
Analysis of the genetic background associated with sporadic periodic paralysis in Japanese patients. 61
32234253 2020
6
Thyrotoxic Periodic Paralysis With Features of Andersen-Tawil Syndrome: A Case Report and Literature Review. 61
32432016 2020
7
Thyrotoxic Periodic Paralysis-A Misleading Challenge in the Emergency Department. 61
32443393 2020
8
THYROTOXIC PERIODIC PARALYSIS AND COMPLICATED THYROTOXICOSIS, TWO PRESENTATIONS OF HYPERTHYROIDISM WITH NOTABLE DIFFERENCES IN THEIR CLINICAL MANIFESTATIONS. AN EXPERIENCE FROM A TERTIARY CARE HOSPITAL IN THE UNITED STATES. 61
32160042 2020
9
Unusual Clinical Presentation of Periodic Paralysis: Case Report and Literature Review. 61
32274285 2020
10
Stroke Mimic: A Case of Unilateral Thyrotoxic Hypokalemic Periodic Paralysis. 61
32064432 2020
11
Thyrotoxic Periodic Paralysis: An Incidental Diagnosis! 61
32211273 2020
12
Thyrotoxic periodic paralysis presenting in an African-American teenage male: case report. 61
32346386 2020
13
Thyrotoxic periodic paralysis: A retrospective, observational study from India. 61
32134013 2020
14
Low-dose oral propranolol for treatment of thyrotoxic periodic paralysis with hypokalaemia in the emergency department: A case report. 61
31913531 2020
15
Contribution of Asian Haplotype of KCNJ18 to Susceptibility to and Ethnic Differences in Thyrotoxic Periodic Paralysis. 61
31361309 2019
16
A Case of Gitelman Syndrome that Was Difficult to Distinguish from Hypokalemic Periodic Paralysis Caused by Graves' Disease. 61
31105122 2019
17
Thyrotoxic Periodic Paralysis with Hypokalemia in an Adult Male from Nepal: A Case Report. 61
32335663 2019
18
Thyrotoxic Periodic Paralysis: A Spine Consultation. 61
31875199 2019
19
Hypokalemic thyrotoxic periodic paralysis. Report of one case. 61
30236802 2019
20
A rare case of hypokalemic ventricular tachycardia in a patient with thyrotoxic periodic paralysis. 61
31879609 2019
21
Don't Trip Over the Trop: An Unusual Presentation of Thyrotoxic Periodic Paralysis. 61
31077655 2019
22
Thyrotoxic Periodic Paralysis. 61
31933322 2019
23
Thyrotoxic hypokalemic periodic paralysis due to Graves' disease in 2 adolescents. 61
31261479 2019
24
Thyrotoxic periodic paralysis with ventricular tachycardia. 61
30965211 2019
25
Assessment of Molecular Subtypes in Thyrotoxic Periodic Paralysis and Graves Disease Among Chinese Han Adults: A Population-Based Genome-Wide Association Study. 61
31050781 2019
26
Thyrotoxic periodic paralysis complicated by life-threatening acute hypercapnic respiratory failure in a Chinese male with painless thyroiditis. 61
30424987 2019
27
[Muscle weakness with hypokalemia and hyperthyroidism in an adolescent with Down syndrome]. 61
30652453 2019
28
Thyrotoxic hypokalemic periodic paralysis: a life-threatening disorder in Asian men. 61
30305000 2019
29
HYPOKALEMIC PERIODIC PARALYSIS IN A PATIENT WITH EUTHYROID GRAVES DISEASE AND CELIAC DISEASE. 61
31967006 2019
30
Hypokalemic Periodic Paralysis as the First Manifestation of Thyrotropin-Secreting Pituitary Adenoma. 61
31737378 2019
31
Clinical and Etiological Spectrum of Hypokalemic Periodic Paralysis in a Tertiary Care Hospital in Pakistan. 61
30931192 2019
32
Thyrotoxic Periodic Paralysis with Sensory Deficits in Young African American Male: A Case Report and Literature Review. 61
31404457 2019
33
Lift Then Shift: Thyrotoxic Periodic Paralysis. 61
30201247 2019
34
A Rare Case of Thyrotoxic Periodic Paralysis After Epidural Steroid Injection: A Case Report and Literature Review. 61
30531678 2018
35
Thyroxine-induced periodic paralysis: a rare complication of nutritional supplements. 61
30567254 2018
36
Thyrotoxic hypokalemic periodic paralysis. 61
30169664 2018
37
Complicated Gitelman syndrome and autoimmune thyroid disease: a case report with a new homozygous mutation in the SLC12A3 gene and literature review. 61
30409157 2018
38
Periodic paralysis with normokalemia in a patient with hyperthyroidism: A case report. 61
30431611 2018
39
Does thyrotoxic periodic paralysis have a genetic predisposition? A case report. 61
29886759 2018
40
Thyrotoxic periodic paralysis: case report and review of the literature. 61
30214699 2018
41
Changing Management Guidelines in Thyrotoxic Hypokalemic Periodic Paralysis. 61
29871829 2018
42
An atypical presentation of high potassium renal secretion rate in a patient with thyrotoxic periodic paralysis: a case report. 61
29973184 2018
43
Thyrotoxic Periodic Paralysis and Cardiomyopathy in a Patient with Graves' Disease. 61
30131930 2018
44
Thyrotoxic Hypokalemic Periodic Paralysis. 61
29910553 2018
45
Thyrotoxic Periodic Paralysis as a Presentation of Thyrotoxicosis: A Case Report and review of the literature. 61
32185297 2018
46
Steroids and Thyrotoxicosis Precipitate Periodic Paralysis. 61
29581918 2018
47
Graves' Disease Presenting with Periodic Paralysis to the Emergency Department. 61
29984010 2018
48
Recognizing thyrotoxic hypokalemic periodic paralysis. 61
29278563 2018
49
Bilateral Lower Extremity Paralysis in a Caucasian Male Presenting to the Emergency Department. 61
29862090 2018
50
Long Exercise Test in the Interattack Period of Periodic Paralysis: A Useful and Sensitive Diagnostic Tool. 61
28742635 2017

Variations for Thyrotoxic Periodic Paralysis

Expression for Thyrotoxic Periodic Paralysis

Search GEO for disease gene expression data for Thyrotoxic Periodic Paralysis.

Pathways for Thyrotoxic Periodic Paralysis

Pathways related to Thyrotoxic Periodic Paralysis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.85 TSHR CACNA1S ATP1B4 ATP1B2 ATP1B1 ATP1A2
2
Show member pathways
12.75 KCNJ2 CACNA1S ATP1B2 ATP1B1 ATP1A2 ATP1A1
3
Show member pathways
12.71 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
4
Show member pathways
12.56 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
5
Show member pathways
12.5 CACNA1S ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
6
Show member pathways
12.45 GABRA3 ATP1B2 ATP1B1 ATP1A2 ATP1A1
7
Show member pathways
12.39 CACNA1S ATP1B2 ATP1B1 ADRB2
8 12.16 KCNJ2 KCNJ16 CACNA1S
9 12 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
10
Show member pathways
11.94 CACNA1S ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
11 11.92 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
12
Show member pathways
11.91 KCNJ2 KCNJ16 GABRA3
13 11.89 TSHR CACNA1S ATP1B4 ATP1B2 ATP1B1 ATP1A2
14 11.85 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
15 11.67 CACNA1S ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
16 11.64 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
17 11.61 KCNJ2 CACNA1S ADRB2
18 11.56 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
19 11.5 KCNJ2 ATP1A1 ADRB2
20 11.47 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
21
Show member pathways
11.45 KCNJ2 KCNJ16 ATP1B4 ATP1B2 ATP1B1 ATP1A2
22 11.29 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
23 11.15 TSHR ADRB2
24 11.03 ATP1B2 ATP1B1
25 10.92 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1

GO Terms for Thyrotoxic Periodic Paralysis

Cellular components related to Thyrotoxic Periodic Paralysis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.23 TSHR KCNJ2 KCNJ18 KCNJ16 GABRA3 CACNA1S
2 plasma membrane GO:0005886 10.06 TSHR KCNJ2 KCNJ18 KCNJ16 GABRA3 CACNA1S
3 integral component of membrane GO:0016021 10.03 TSHR KCNJ2 KCNJ18 KCNJ16 GABRA3 CACNA1S
4 cell GO:0005623 9.93 KCNJ2 ATP1B2 ATP1B1 ATP1A2 ATP1A1
5 apical plasma membrane GO:0016324 9.78 ATP1B2 ATP1B1 ATP1A1 ADRB2
6 extracellular vesicle GO:1903561 9.7 ATP1B1 ATP1A2 ATP1A1
7 organelle membrane GO:0031090 9.69 ATP1B1 ATP1A2 ATP1A1
8 sarcolemma GO:0042383 9.67 ATP1B1 ATP1A2 ATP1A1
9 basolateral plasma membrane GO:0016323 9.67 TSHR KCNJ16 ATP1B1 ATP1A1
10 caveola GO:0005901 9.61 ATP1B1 ATP1A2 ATP1A1
11 lateral plasma membrane GO:0016328 9.58 ATP1B2 ATP1B1 ATP1A1
12 intercalated disc GO:0014704 9.46 KCNJ2 ATP1B1 ATP1A2 ATP1A1
13 T-tubule GO:0030315 9.35 KCNJ2 CACNA1S ATP1B1 ATP1A2 ATP1A1
14 sodium:potassium-exchanging ATPase complex GO:0005890 9.02 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1

Biological processes related to Thyrotoxic Periodic Paralysis according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.97 KCNJ16 GABRA3 ATP1B2 ATP1B1 ATP1A2 ATP1A1
2 sodium ion transport GO:0006814 9.91 ATP1B4 ATP1B2 ATP1B1 ATP1A2 ATP1A1
3 regulation of ion transmembrane transport GO:0034765 9.87 KCNJ2 KCNJ18 KCNJ16 CACNA1S
4 potassium ion transmembrane transport GO:0071805 9.86 KCNJ2 KCNJ16 ATP1B1 ATP1A2
5 ion transport GO:0006811 9.85 KCNJ2 KCNJ18 KCNJ16 GABRA3 CACNA1S ATP1B4
6 regulation of cardiac conduction GO:1903779 9.83 ATP1B2 ATP1B1 ATP1A2 ATP1A1
7 cellular response to mechanical stimulus GO:0071260 9.78 KCNJ2 ATP1A2 ATP1A1
8 cellular sodium ion homeostasis GO:0006883 9.78 ATP1B2 ATP1B1 ATP1A2 ATP1A1
9 cell communication by electrical coupling involved in cardiac conduction GO:0086064 9.76 ATP1B2 ATP1B1 ATP1A2 ATP1A1
10 sodium ion export across plasma membrane GO:0036376 9.73 ATP1B2 ATP1B1 ATP1A2 ATP1A1
11 regulation of cardiac muscle cell contraction GO:0086004 9.72 KCNJ2 ATP1A2 ATP1A1
12 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.71 KCNJ2 ATP1B1 ATP1A1
13 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.71 ATP1B2 ATP1B1 ATP1A2 ATP1A1
14 relaxation of cardiac muscle GO:0055119 9.67 KCNJ2 ATP1B1 ATP1A2 ATP1A1
15 activation of adenylate cyclase activity GO:0007190 9.66 TSHR ADRB2
16 positive regulation of ATPase activity GO:0032781 9.65 ATP1B2 ATP1B1
17 ATP metabolic process GO:0046034 9.65 ATP1B1 ATP1A2
18 regulation of sodium ion transport GO:0002028 9.65 ATP1A1 ADRB2
19 cellular potassium ion homeostasis GO:0030007 9.65 KCNJ2 ATP1B2 ATP1B1 ATP1A2 ATP1A1
20 regulation of the force of heart contraction GO:0002026 9.64 ATP1A2 ATP1A1
21 regulation of smooth muscle contraction GO:0006940 9.64 ATP1A2 ADRB2
22 cardiac muscle cell action potential involved in contraction GO:0086002 9.63 KCNJ2 ATP1A1
23 cellular response to steroid hormone stimulus GO:0071383 9.63 ATP1A2 ATP1A1
24 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.62 KCNJ2 ATP1A2
25 positive regulation of heart contraction GO:0045823 9.62 ATP1A2 ATP1A1
26 membrane repolarization GO:0086009 9.62 ATP1B2 ATP1B1 ATP1A2 ATP1A1
27 negative regulation of heart contraction GO:0045822 9.61 ATP1A2 ATP1A1
28 positive regulation of potassium ion import GO:1903288 9.6 ATP1B2 ATP1B1
29 positive regulation of potassium ion transmembrane transporter activity GO:1901018 9.59 ATP1B2 ATP1B1
30 response to glycoside GO:1903416 9.58 ATP1A2 ATP1A1
31 positive regulation of sodium ion export across plasma membrane GO:1903278 9.58 ATP1B2 ATP1B1
32 potassium ion transport GO:0006813 9.56 KCNJ2 KCNJ18 KCNJ16 ATP1B4 ATP1B2 ATP1B1
33 potassium ion import across plasma membrane GO:1990573 9.17 KCNJ2 KCNJ18 KCNJ16 ATP1B2 ATP1B1 ATP1A2

Molecular functions related to Thyrotoxic Periodic Paralysis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.73 ATP1B2 ATP1B1 ATP1A2 ATP1A1
2 voltage-gated ion channel activity GO:0005244 9.62 KCNJ2 KCNJ18 KCNJ16 CACNA1S
3 ATPase activator activity GO:0001671 9.48 ATP1B2 ATP1B1
4 cation-transporting ATPase activity GO:0019829 9.46 ATP1B1 ATP1A2
5 inward rectifier potassium channel activity GO:0005242 9.43 KCNJ2 KCNJ18 KCNJ16
6 potassium-transporting ATPase activity GO:0008556 9.4 ATP1A2 ATP1A1
7 steroid hormone binding GO:1990239 9.37 ATP1A2 ATP1A1
8 potassium ion binding GO:0030955 9.33 ATP1B1 ATP1A2 ATP1A1
9 sodium ion binding GO:0031402 9.13 ATP1B1 ATP1A2 ATP1A1
10 sodium:potassium-exchanging ATPase activity GO:0005391 8.92 ATP1B2 ATP1B1 ATP1A2 ATP1A1

Sources for Thyrotoxic Periodic Paralysis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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