MCID: TBL001
MIFTS: 27

Tibial Nerve Palsy

Categories: Neuronal diseases

Aliases & Classifications for Tibial Nerve Palsy

MalaCards integrated aliases for Tibial Nerve Palsy:

Name: Tibial Nerve Palsy 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:12529
SNOMED-CT 67 359842002
UMLS 70 C0154751

Summaries for Tibial Nerve Palsy

MalaCards based summary : Tibial Nerve Palsy is related to inflammatory bowel disease 14 and epiglottis cancer. An important gene associated with Tibial Nerve Palsy is PMP22 (Peripheral Myelin Protein 22), and among its related pathways/superpathways are Neuroscience and NF-kappaB Signaling. Affiliated tissues include bone, myeloid and bone marrow, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Tibial Nerve Palsy

Diseases related to Tibial Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 inflammatory bowel disease 14 10.1 THY1 NT5E
2 epiglottis cancer 10.1 ENG CD34
3 capillary lymphangioma 10.1 ENG CD34
4 congenital granular cell tumor 10.1 ENG CD34
5 lower lip cancer 10.1 ENG CD34
6 tibial neuropathy 10.0
7 mononeuropathy 10.0
8 paresthesia 10.0
9 central nervous system leukemia 10.0 CD34 CD19
10 invasive malignant thymoma 10.0 CD34 CD19
11 multifocal osteogenic sarcoma 9.9 PTPRC CD34
12 vascular cancer 9.9 ENG CD34
13 osteochondrodysplasia 9.9 THY1 NT5E ENG
14 glomangiomatosis 9.8 PTPRC CD34
15 conventional fibrosarcoma 9.8 PTPRC CD34
16 mediastinal cancer 9.8 PTPRC CD34
17 retroperitoneum carcinoma 9.8 PTPRC CD34
18 spastic paraplegia 3, autosomal dominant 9.8 THY1 PTPRC
19 cardiovascular organ benign neoplasm 9.8 ENG CD34
20 blood protein disease 9.8 CD34 CD19
21 mental retardation, autosomal dominant 36 9.8 PTPRC CD19
22 myeloid sarcoma 9.8 PTPRC CD34
23 listeriosis 9.8 PTPRC ITGAM
24 brachydactyly, type c 9.8 PTPRC ITGAM
25 dental pulp necrosis 9.8 THY1 NT5E MCAM ENG
26 dental pulp disease 9.8 THY1 NT5E MCAM ENG
27 thymus gland disease 9.7 PTPRC CD34
28 t cell deficiency 9.7 PTPRC CD19
29 retinitis pigmentosa 23 9.7 PTPRC ITGAM
30 monoclonal gammopathy of uncertain significance 9.7 PTPRC CD19
31 mobitz type ii atrioventricular block 9.7 THY1 MCAM ENG CD34
32 waldenstroem's macroglobulinemia 9.7 PTPRC CD19
33 idiopathic interstitial pneumonia 9.7 PTPRC CD34
34 glomeruloid hemangioma 9.7 PTPRC ENG CD34
35 germ cell and embryonal cancer 9.7 THY1 NT5E ENG CD34
36 demyelinating disease 9.6 PTPRC PMP22 CD34
37 ectodermal dysplasia 1, hypohidrotic, x-linked 9.6 THY1 PTPRC ITGAM
38 ectodermal dysplasia 10b, hypohidrotic/hair/tooth type, autosomal recessive 9.6 THY1 PTPRC ITGAM
39 x-linked recessive disease 9.6 PTPRC ITGAM CD34
40 hypotrichosis 1 9.5 PTPRC ITGAM CD19
41 primary bacterial infectious disease 9.5 PTPRC ITGAM CD19
42 autoimmune disease of central nervous system 9.5 PTPRC ITGAM CD19
43 autoimmune disease of the nervous system 9.5 PTPRC ITGAM CD19
44 b-lymphoblastic leukemia/lymphoma 9.5 PTPRC CD34 CD19
45 autoimmune disease of musculoskeletal system 9.5 PTPRC ITGAM CD19
46 blood platelet disease 9.5 PTPRC CD34 CD19
47 blood coagulation disease 9.5 PTPRC CD34 CD19
48 bone marrow cancer 9.5 PTPRC CD34 CD19
49 lymphatic system disease 9.5 PTPRC CD34 CD19
50 severe combined immunodeficiency 9.5 PTPRC CD34 CD19

Graphical network of the top 20 diseases related to Tibial Nerve Palsy:



Diseases related to Tibial Nerve Palsy

Symptoms & Phenotypes for Tibial Nerve Palsy

MGI Mouse Phenotypes related to Tibial Nerve Palsy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.5 CD19 CD34 ENG ITGAM MCAM NT5E
2 homeostasis/metabolism MP:0005376 9.23 CD19 CD34 ENG ITGAM MCAM NT5E

Drugs & Therapeutics for Tibial Nerve Palsy

Search Clinical Trials , NIH Clinical Center for Tibial Nerve Palsy

Genetic Tests for Tibial Nerve Palsy

Anatomical Context for Tibial Nerve Palsy

MalaCards organs/tissues related to Tibial Nerve Palsy:

40
Bone, Myeloid, Bone Marrow, Thymus

Publications for Tibial Nerve Palsy

Articles related to Tibial Nerve Palsy:

(show all 23)
# Title Authors PMID Year
1
Idiopathic Pediatric Tibial Nerve Palsy. 61
33747694 2021
2
[A case of tibial nerve palsy due to intraneural ganglion cysts]. 61
32641634 2020
3
Tibial Nerve Palsy After Lateralizing Calcaneal Osteotomy. 61
30499329 2019
4
Tibial nerve palsy as the presenting feature of posterior tibial artery pseudoaneurysm. 61
27806430 2018
5
Rate of Neurologic Injury Following Lateralizing Calcaneal Osteotomy Performed Through a Medial Approach. 61
28863729 2017
6
A rare case of an acute soleus arcade syndrome complicated by a ganglion cyst: diagnosis by dynamic ultrasound. 61
29197923 2017
7
Fracture Table Application for Pediatric Femur Fractures: Incidence and Risk Factors Associated With Adverse Outcomes. 61
28719546 2017
8
Transient Common Peroneal and Tibial Nerve Palsy Following Knee Arthroscopy for the Treatment of Discoid Lateral Meniscus. 61
29114641 2017
9
Tibial Nerve Palsy by a Crossing Posterior Tibial Artery Branch After Lateral Sliding Calcaneal Osteotomy. 61
28457168 2017
10
Neurologic Deficit Associated With Lateralizing Calcaneal Osteotomy for Cavovarus Foot Correction. 61
27340259 2016
11
[Effectiveness of very low profile/variable angle locking plate internal fixation in treatment of posterior Pilon fractures extending to medial malleolus by posteromedial approach]. 61
25073272 2014
12
Correction of a severe poliomyelitic equinocavovarus foot using an adjustable external fixation frame. 61
23890796 2014
13
Tibial nerve palsy associated with lateralizing calcaneal osteotomy: case reviews and technical tip. 61
19321104 2009
14
Popliteus strain causing tibial nerve palsy with a permanent partial deficit: a case report. 61
16452266 2006
15
[Tibia nonunion after intramedullar nailing for fracture: decortication and osteosynthesis by medial plating]. 61
15976666 2005
16
Percutaneous versus open bone grafting in the treatment of tibial fractures: a randomized prospective trial. 61
15516003 2004
17
MRI of peripheral nerve lesions of the lower limbs. 61
12684721 2003
18
[Hereditary neuropathy with liability to pressure palsies (tomaculous neuropathy). Clinical, electrophysical and molecular study of two affected families]. 61
11055050 2000
19
Tourniquet-induced tibial nerve palsy complicating anterior cruciate ligament reconstruction. 61
8534308 1995
20
Posterior tibial nerve palsy after intramedullary nailing. 61
8500932 1993
21
Isolated rupture of the popliteus with posterior tibial nerve palsy. 61
1447239 1992
22
Anterior tibial nerve palsy after ankle arthrocentesis. 61
6838684 1983
23
[Case of tibial nerve palsy caused by Baker's cyst]. 61
5599343 1967

Variations for Tibial Nerve Palsy

Expression for Tibial Nerve Palsy

Search GEO for disease gene expression data for Tibial Nerve Palsy.

Pathways for Tibial Nerve Palsy

GO Terms for Tibial Nerve Palsy

Cellular components related to Tibial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.02 THY1 PTPRC PMP22 NT5E MCAM ITGAM
2 plasma membrane GO:0005886 9.81 THY1 PTPRC PMP22 NT5E MCAM ITGAM
3 focal adhesion GO:0005925 9.62 THY1 PTPRC MCAM ENG
4 membrane raft GO:0045121 9.56 THY1 PTPRC ITGAM CD19
5 cell surface GO:0009986 9.43 THY1 PTPRC NT5E ITGAM ENG CD34
6 external side of plasma membrane GO:0009897 9.23 THY1 PTPRC NT5E MCAM ITGAM ENG

Biological processes related to Tibial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 angiogenesis GO:0001525 9.63 THY1 MCAM ENG
2 cell motility GO:0048870 9.48 ENG CD34
3 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.43 THY1 CD19
4 leukocyte cell-cell adhesion GO:0007159 9.4 PTPRC NT5E
5 negative regulation of interleukin-2 production GO:0032703 9.37 PTPRC CD34
6 negative regulation of protein tyrosine kinase activity GO:0061099 9.32 THY1 PTPRC
7 glomerular filtration GO:0003094 9.26 MCAM CD34
8 negative regulation of protein autophosphorylation GO:0031953 9.16 PTPRC ENG
9 cell adhesion GO:0007155 9.02 THY1 MCAM ITGAM ENG CD34
10 vascular wound healing GO:0061042 8.96 MCAM CD34

Sources for Tibial Nerve Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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