Tibialis Tendinitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Tibialis Tendinitis

MalaCards integrated aliases for Tibialis Tendinitis:

Name: Tibialis Tendinitis ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:10810

ICD9CM ³⁴ 726.72

SNOMED-CT ⁶⁷ 50127006

UMLS ⁷¹ C0158321

Sources

Summaries for Tibialis Tendinitis

MalaCards based summary : Tibialis Tendinitis is related to ureteric orifice cancer and ehlers-danlos syndrome, classic type, 2. An important gene associated with Tibialis Tendinitis is ADAMTS14 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14), and among its related pathways/superpathways are Focal Adhesion and Collagen chain trimerization. Affiliated tissues include bone, and related phenotypes are cardiovascular system and integument

Sources

Related Diseases for Tibialis Tendinitis

Diseases related to Tibialis Tendinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)

#	Related Disease	Score	Top Affiliating Genes
1	ureteric orifice cancer	10.0	TNXB FBLN5
2	ehlers-danlos syndrome, classic type, 2	10.0	COL5A2 COL5A1
3	ehlers-danlos syndrome, classic type, 1	9.9	COL5A2 COL5A1
4	pelvic organ prolapse	9.9	TNXB FBLN5
5	caspase 8 deficiency	9.9	COL5A2 COL5A1
6	nail-patella syndrome	9.9	COL5A2 COL5A1
7	brittle cornea syndrome 2	9.9	COL5A2 COL5A1
8	osteogenesis imperfecta, type ii	9.9	COL5A2 COL5A1
9	telecanthus	9.8	COL5A2 COL11A1
10	otospondylomegaepiphyseal dysplasia	9.8	COL5A2 COL11A1
11	otospondylomegaepiphyseal dysplasia, autosomal dominant	9.8	COL5A2 COL11A1
12	brittle bone disorder	9.8	COL5A2 COL5A1
13	stickler syndrome	9.7	COL5A2 COL11A1
14	classic ehlers-danlos syndrome	9.6	TNXB COL5A2 COL5A1
15	osteogenesis imperfecta, type iii	9.6	COL5A2 COL11A1
16	ehlers-danlos syndrome	9.6	TNXB COL5A2 COL5A1
17	hypermobility syndrome	9.6	TNXB COL5A2 COL5A1
18	collagen disease	9.6	TNXB COL5A2 COL5A1
19	inguinal hernia	9.6	FBLN5 COL5A1
20	orthostatic intolerance	9.6	TNXB COL5A2 COL5A1
21	aortic aneurysm, familial thoracic 1	9.6	FBLN5 COL5A2 COL5A1
22	loeys-dietz syndrome	9.6	FBLN5 COL5A2 COL5A1
23	cutis laxa	9.5	FBLN5 COL5A1
24	marfan syndrome	9.5	COL5A2 COL5A1
25	connective tissue disease	9.4	TNXB FBLN5 COL5A1

Graphical network of the top 20 diseases related to Tibialis Tendinitis:

Sources

Symptoms & Phenotypes for Tibialis Tendinitis

MGI Mouse Phenotypes related to Tibialis Tendinitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.55	B4GALT1 COL5A1 COL5A2 FBLN5 TNXB
2	integument	MP:0010771	9.35	B4GALT1 COL5A1 COL5A2 FBLN5 TNXB
3	respiratory system	MP:0005388	8.92	B4GALT1 COL11A1 COL5A2 FBLN5

Sources

Drugs & Therapeutics for Tibialis Tendinitis

Search Clinical Trials , NIH Clinical Center for Tibialis Tendinitis

Sources

Genetic Tests for Tibialis Tendinitis

Sources

Anatomical Context for Tibialis Tendinitis

MalaCards organs/tissues related to Tibialis Tendinitis:

⁴⁰

Bone

Sources

Publications for Tibialis Tendinitis

Articles related to Tibialis Tendinitis:

#	Title	Authors	PMID	Year
1	Usefulness of oblique axial scan in magnetic resonance imaging evaluation of anterior talofibular ligament in ankle sprain. ⁶¹	Kim JS...Lee KT	22244161	2012
2	Running shoes, orthotics, and injuries. ⁶¹	McKenzie DC...Taunton JE	3850616	1985
3	Heel counter stabilization of the running shoe. ⁶¹	Goldberg DA...Whitesel DL	18806425	1983

Sources

Genes for Tibialis Tendinitis

Genes related to Tibialis Tendinitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ADAMTS14	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14	Protein Coding	5.61	DISEASES inferred ¹⁵
2	COL5A2	Collagen Type V Alpha 2 Chain	Protein Coding	4.72	DISEASES inferred ¹⁵
3	TNXB	Tenascin XB	Protein Coding	4.67	DISEASES inferred ¹⁵
4	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	4.65	DISEASES inferred ¹⁵
5	COL5A1	Collagen Type V Alpha 1 Chain	Protein Coding	4.54	DISEASES inferred ¹⁵
6	COL11A1	Collagen Type XI Alpha 1 Chain	Protein Coding	4.5	DISEASES inferred ¹⁵
7	FBLN5	Fibulin 5	Protein Coding	4.5	DISEASES inferred ¹⁵

Sources

Variations for Tibialis Tendinitis

Sources

Expression for Tibialis Tendinitis

Search GEO for disease gene expression data for Tibialis Tendinitis.

Sources

Pathways for Tibialis Tendinitis

Pathways related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Focal Adhesion ¹ ³⁶ Show member pathways HGF Pathway ⁶³ Integrin-mediated Cell Adhesion ¹	12.32	TNXB COL5A2 COL5A1 COL11A1
2	Collagen chain trimerization ⁶⁵ Show member pathways Anchoring fibril formation ⁶⁵ Assembly of collagen fibrils and other multimeric structures ⁶⁵ Blood Coagulation Cascade ⁶³ Collagen biosynthesis and modifying enzymes ⁶⁵ Collagen formation ⁶⁵ Crosslinking of collagen fibrils ⁶⁵ Intrinsic Prothrombin Activation Pathway ⁶³ Protein digestion and absorption ³⁶	12.18	COL5A2 COL5A1 COL11A1 ADAMTS14
3	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	11.75	TNXB FBLN5 COL5A2 COL5A1 COL11A1 ADAMTS14
4	miRNA targets in ECM and membrane receptors ¹	10.77	TNXB COL5A2 COL5A1
5	G-protein signaling_Rap2B regulation pathway ²²	10.4	COL5A2 COL5A1 COL11A1

Sources

GO Terms for Tibialis Tendinitis

Cellular components related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.8	TNXB FBLN5 COL5A2 COL5A1 COL11A1 B4GALT1
2	extracellular region	GO:0005576	9.7	TNXB FBLN5 COL5A2 COL5A1 COL11A1 B4GALT1
3	endoplasmic reticulum lumen	GO:0005788	9.58	COL5A2 COL5A1 COL11A1
4	collagen trimer	GO:0005581	9.54	COL5A2 COL5A1 COL11A1
5	collagen-containing extracellular matrix	GO:0062023	9.35	TNXB FBLN5 COL5A2 COL5A1 COL11A1
6	collagen type V trimer	GO:0005588	9.26	COL5A2 COL5A1
7	extracellular matrix	GO:0031012	9.02	TNXB FBLN5 COL5A2 COL5A1 COL11A1

Biological processes related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cell adhesion	GO:0007155	9.71	TNXB FBLN5 COL5A1 B4GALT1
2	ossification	GO:0001503	9.48	COL5A2 COL11A1
3	heart morphogenesis	GO:0003007	9.46	COL5A1 COL11A1
4	skin development	GO:0043588	9.43	COL5A2 COL5A1
5	extracellular matrix organization	GO:0030198	9.43	TNXB FBLN5 COL5A2 COL5A1 COL11A1 B4GALT1
6	elastic fiber assembly	GO:0048251	9.37	TNXB FBLN5
7	tendon development	GO:0035989	9.32	COL5A1 COL11A1
8	eye morphogenesis	GO:0048592	9.26	COL5A2 COL5A1
9	negative regulation of endodermal cell differentiation	GO:1903225	9.16	COL5A2 COL5A1
10	collagen fibril organization	GO:0030199	9.02	TNXB COL5A2 COL5A1 COL11A1 ADAMTS14

Molecular functions related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	heparin binding	GO:0008201	9.43	TNXB COL5A1 COL11A1
2	integrin binding	GO:0005178	9.33	TNXB FBLN5 COL5A1
3	extracellular matrix structural constituent conferring tensile strength	GO:0030020	9.13	COL5A2 COL5A1 COL11A1
4	extracellular matrix structural constituent	GO:0005201	8.92	TNXB COL5A2 COL5A1 COL11A1

Sources

Sources for Tibialis Tendinitis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia