Tibialis Tendinitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Tibialis Tendinitis

MalaCards integrated aliases for Tibialis Tendinitis:

Name: Tibialis Tendinitis ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:10810

ICD9CM ³⁴ 726.72

SNOMED-CT ⁶⁷ 50127006

UMLS ⁷¹ C0158321

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Summaries for Tibialis Tendinitis

MalaCards based summary : Tibialis Tendinitis is related to geleophysic dysplasia and weill-marchesani syndrome. An important gene associated with Tibialis Tendinitis is ADAMTS14 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. Related phenotypes are integument and respiratory system

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Related Diseases for Tibialis Tendinitis

Diseases related to Tibialis Tendinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)

#	Related Disease	Score	Top Affiliating Genes
1	geleophysic dysplasia	9.9	FBN2 ADAMTS2
2	weill-marchesani syndrome	9.9	FBN2 ADAMTS2
3	pelvic organ prolapse	9.9	TNXB ADAMTS2
4	cakut	9.8	TNXB FBN2
5	osteogenesis imperfecta, type ii	9.7	COL5A2 ADAMTS2
6	hypermobile ehlers-danlos syndrome	9.7	TNXB COL5A2
7	classic ehlers-danlos syndrome	9.7	TNXB COL5A2
8	hypermobility syndrome	9.7	TNXB COL5A2
9	osteogenesis imperfecta, type iii	9.7	COL5A2 ADAMTS2
10	loeys-dietz syndrome	9.7	FBN2 COL5A2
11	stickler syndrome	9.6	FBN2 COL5A2
12	aortic dissection	9.6	FBN2 COL5A2
13	odontochondrodysplasia	9.5	FBN2 COL5A2 ADAMTS2
14	collagen disease	9.5	TNXB COL5A2 ADAMTS2
15	orthostatic intolerance	9.5	TNXB FBN2 COL5A2
16	marfan syndrome	9.5	FBN2 COL5A2
17	ehlers-danlos syndrome	9.5	TNXB COL5A2 ADAMTS2
18	brittle bone disorder	9.5	TNXB COL5A2 ADAMTS2
19	connective tissue disease	9.2	TNXB FBN2 COL5A2 ADAMTS2

Graphical network of the top 20 diseases related to Tibialis Tendinitis:

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Symptoms & Phenotypes for Tibialis Tendinitis

MGI Mouse Phenotypes related to Tibialis Tendinitis:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.43	ADAMTS14 ADAMTS2 B4GALT1 COL5A2 FBN2 TNXB
2	respiratory system	MP:0005388	8.92	ADAMTS2 B4GALT1 COL5A2 FBN2

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Drugs & Therapeutics for Tibialis Tendinitis

Search Clinical Trials , NIH Clinical Center for Tibialis Tendinitis

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Genetic Tests for Tibialis Tendinitis

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Anatomical Context for Tibialis Tendinitis

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Publications for Tibialis Tendinitis

Articles related to Tibialis Tendinitis:

#	Title	Authors	PMID	Year
1	Usefulness of oblique axial scan in magnetic resonance imaging evaluation of anterior talofibular ligament in ankle sprain. ⁶¹	Kim JS...Lee KT	22244161	2012
2	Running shoes, orthotics, and injuries. ⁶¹	McKenzie DC...Taunton JE	3850616	1985
3	Heel counter stabilization of the running shoe. ⁶¹	Goldberg DA...Whitesel DL	18806425	1983

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Genes for Tibialis Tendinitis

Genes related to Tibialis Tendinitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ADAMTS14	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14	Protein Coding	5.56	DISEASES inferred ¹⁵
2	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	4.97	DISEASES inferred ¹⁵
3	ADAMTS2	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 2	Protein Coding	4.82	DISEASES inferred ¹⁵
4	TNXB	Tenascin XB	Protein Coding	4.65	DISEASES inferred ¹⁵
5	COL5A2	Collagen Type V Alpha 2 Chain	Protein Coding	4.6	DISEASES inferred ¹⁵
6	FBN2	Fibrillin 2	Protein Coding	4.6	DISEASES inferred ¹⁵

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Variations for Tibialis Tendinitis

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Expression for Tibialis Tendinitis

Search GEO for disease gene expression data for Tibialis Tendinitis.

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Pathways for Tibialis Tendinitis

Pathways related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Collagen chain trimerization ⁶⁵ Show member pathways Anchoring fibril formation ⁶⁵ Assembly of collagen fibrils and other multimeric structures ⁶⁵ Blood Coagulation Cascade ⁶³ Collagen biosynthesis and modifying enzymes ⁶⁵ Collagen formation ⁶⁵ Crosslinking of collagen fibrils ⁶⁵ Intrinsic Prothrombin Activation Pathway ⁶³ Protein digestion and absorption ³⁶	12.17	COL5A2 ADAMTS2 ADAMTS14
2	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	11.67	TNXB FBN2 COL5A2 ADAMTS2 ADAMTS14
3	Diseases of glycosylation ⁶⁵ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁵	11.49	ADAMTS2 ADAMTS14
4	O-glycosylation of TSR domain-containing proteins ⁶⁵ Show member pathways Defective B3GALTL causes Peters-plus syndrome (PpS) ⁶⁵	11.04	ADAMTS2 ADAMTS14
5	miRNA targets in ECM and membrane receptors ¹	10.59	TNXB COL5A2

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GO Terms for Tibialis Tendinitis

Cellular components related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.63	TNXB FBN2 COL5A2 B4GALT1 ADAMTS2 ADAMTS14
2	collagen-containing extracellular matrix	GO:0062023	9.26	TNXB FBN2 COL5A2 ADAMTS2
3	extracellular matrix	GO:0031012	9.02	TNXB FBN2 COL5A2 ADAMTS2 ADAMTS14

Biological processes related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	skin development	GO:0043588	9.26	COL5A2 ADAMTS2
2	collagen fibril organization	GO:0030199	9.26	TNXB COL5A2 ADAMTS2 ADAMTS14
3	collagen catabolic process	GO:0030574	9.16	ADAMTS2 ADAMTS14
4	extracellular matrix organization	GO:0030198	9.1	TNXB FBN2 COL5A2 B4GALT1 ADAMTS2 ADAMTS14

Molecular functions related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	metallopeptidase activity	GO:0008237	9.16	ADAMTS2 ADAMTS14
2	metalloendopeptidase activity	GO:0004222	8.96	ADAMTS2 ADAMTS14
3	extracellular matrix structural constituent	GO:0005201	8.8	TNXB FBN2 COL5A2

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Sources for Tibialis Tendinitis

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