Tibialis Tendinitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Tibialis Tendinitis

MalaCards integrated aliases for Tibialis Tendinitis:

Name: Tibialis Tendinitis ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Muscle diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:10810

ICD9CM ³⁴ 726.72

SNOMED-CT ⁶⁷ 50127006

UMLS ⁷¹ C0158321

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Summaries for Tibialis Tendinitis

MalaCards based summary : Tibialis Tendinitis is related to classic ehlers-danlos syndrome and hypermobility syndrome. An important gene associated with Tibialis Tendinitis is ADAMTS14 (ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14), and among its related pathways/superpathways are Collagen chain trimerization and Degradation of the extracellular matrix. Related phenotypes are integument and respiratory system

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Related Diseases for Tibialis Tendinitis

Diseases related to Tibialis Tendinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)

#	Related Disease	Score	Top Affiliating Genes
1	classic ehlers-danlos syndrome	9.8	TNXB COL5A2
2	hypermobility syndrome	9.8	TNXB COL5A2
3	brittle cornea syndrome 2	9.8	TNXB COL5A2
4	collagen disease	9.7	TNXB COL5A2
5	familial thoracic aortic aneurysm and aortic dissection	9.7	FBN2 COL5A2
6	pelvic organ prolapse	9.7	TNXB LOXL1
7	aortic aneurysm, familial thoracic 1	9.7	FBN2 COL5A2
8	marfan syndrome	9.5	LOXL1 FBN2 COL5A2
9	loeys-dietz syndrome	9.5	FBN2 COL5A2
10	orthostatic intolerance	9.5	TNXB FBN2 COL5A2
11	ehlers-danlos syndrome	9.5	TNXB FBN2 COL5A2
12	connective tissue disease	9.3	TNXB FBN2 COL5A2

Graphical network of the top 20 diseases related to Tibialis Tendinitis:

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Symptoms & Phenotypes for Tibialis Tendinitis

MGI Mouse Phenotypes related to Tibialis Tendinitis:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	integument	MP:0010771	9.55	B4GALT1 COL5A2 FBN2 LOXL1 TNXB
2	respiratory system	MP:0005388	9.26	B4GALT1 COL5A2 FBN2 LOXL1
3	vision/eye	MP:0005391	8.92	ADAMTS14 COL5A2 FBN2 LOXL1

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Drugs & Therapeutics for Tibialis Tendinitis

Search Clinical Trials , NIH Clinical Center for Tibialis Tendinitis

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Genetic Tests for Tibialis Tendinitis

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Anatomical Context for Tibialis Tendinitis

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Publications for Tibialis Tendinitis

Articles related to Tibialis Tendinitis:

#	Title	Authors	PMID	Year
1	Usefulness of oblique axial scan in magnetic resonance imaging evaluation of anterior talofibular ligament in ankle sprain. ⁶¹	Kim JS...Lee KT	22244161	2012
2	Running shoes, orthotics, and injuries. ⁶¹	McKenzie DC...Taunton JE	3850616	1985
3	Heel counter stabilization of the running shoe. ⁶¹	Goldberg DA...Whitesel DL	18806425	1983

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Genes for Tibialis Tendinitis

Genes related to Tibialis Tendinitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ADAMTS14	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 14	Protein Coding	5.64	DISEASES inferred ¹⁵
2	COL5A2	Collagen Type V Alpha 2 Chain	Protein Coding	4.68	DISEASES inferred ¹⁵
3	FBN2	Fibrillin 2	Protein Coding	4.68	DISEASES inferred ¹⁵
4	TNXB	Tenascin XB	Protein Coding	4.64	DISEASES inferred ¹⁵
5	B4GALT1	Beta-1,4-Galactosyltransferase 1	Protein Coding	4.59	DISEASES inferred ¹⁵
6	LOXL1	Lysyl Oxidase Like 1	Protein Coding	4.52	DISEASES inferred ¹⁵

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Variations for Tibialis Tendinitis

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Expression for Tibialis Tendinitis

Search GEO for disease gene expression data for Tibialis Tendinitis.

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Pathways for Tibialis Tendinitis

Pathways related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Collagen chain trimerization ⁶⁵ Show member pathways Anchoring fibril formation ⁶⁵ Assembly of collagen fibrils and other multimeric structures ⁶⁵ Blood Coagulation Cascade ⁶³ Collagen biosynthesis and modifying enzymes ⁶⁵ Collagen formation ⁶⁵ Crosslinking of collagen fibrils ⁶⁵ Intrinsic Prothrombin Activation Pathway ⁶³ Protein digestion and absorption ³⁶	12.16	LOXL1 COL5A2 ADAMTS14
2	Degradation of the extracellular matrix ⁶⁵ Show member pathways Collagen degradation ⁶⁵ Extracellular matrix organization ⁶⁵	11.67	TNXB LOXL1 FBN2 COL5A2 ADAMTS14
3	Elastic fibre formation ⁶⁵ Show member pathways Molecules associated with elastic fibres ⁶⁵	11.02	LOXL1 FBN2
4	miRNA targets in ECM and membrane receptors ¹	10.59	TNXB COL5A2

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GO Terms for Tibialis Tendinitis

Cellular components related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.63	TNXB LOXL1 FBN2 COL5A2 B4GALT1 ADAMTS14
2	extracellular space	GO:0005615	9.56	TNXB LOXL1 COL5A2 B4GALT1
3	collagen-containing extracellular matrix	GO:0062023	9.26	TNXB LOXL1 FBN2 COL5A2
4	extracellular matrix	GO:0031012	9.02	TNXB LOXL1 FBN2 COL5A2 ADAMTS14

Biological processes related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	collagen fibril organization	GO:0030199	9.26	TNXB LOXL1 COL5A2 ADAMTS14
2	extracellular matrix organization	GO:0030198	9.1	TNXB LOXL1 FBN2 COL5A2 B4GALT1 ADAMTS14

Molecular functions related to Tibialis Tendinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:0005201	8.8	TNXB FBN2 COL5A2

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Sources for Tibialis Tendinitis

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⁷⁴ Wikipedia