Aliases & Classifications for Tic Disorder

Summaries for Tic Disorder

Disease Ontology : 12 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards based summary : Tic Disorder, also known as tics, is related to chronic tic disorder and gilles de la tourette syndrome, and has symptoms including symptoms, recurrent muscle twitches (symptom) and ataxia. An important gene associated with Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Circadian entrainment and Long-term potentiation. The drugs Clopidogrel and Ticagrelor have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 76 Tic disorders is defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Related Diseases for Tic Disorder

Diseases related to Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 chronic tic disorder 33.7 DRD4 OFCC1
2 gilles de la tourette syndrome 31.1 DRD2 DRD4 DRD5 HDC IMMP2L SLC6A3
3 early-onset schizophrenia 29.7 DRD2 DRD4 HTR2A
4 movement disease 29.7 DRD2 SLC18A2 SLC6A3
5 oppositional defiant disorder 29.6 DRD2 DRD4 SLC6A3 TPH2
6 conduct disorder 29.2 DRD2 DRD4 DRD5 SLC6A3
7 obsessive-compulsive disorder 29.2 DRD2 DRD4 HTR2A SLC6A3 SLITRK1 TPH2
8 autism 27.7 DRD2 DRD4 HTR2A IMMP2L SLC6A3 TDO2
9 attention deficit-hyperactivity disorder 27.2 DRD2 DRD4 DRD5 HTR2A IMMP2L SLC18A2
10 schizophrenia 26.9 DRD2 DRD4 DRD5 HTR2A SLC18A2 SLC6A3
11 transient tic disorder 12.5
12 pandas 11.3
13 pediatric acute-onset neuropsychiatric syndrome 10.8
14 delusional disorder 10.6 DRD2 DRD4
15 heroin dependence 10.6 DRD2 DRD4
16 major affective disorder 1 10.6 SLC6A3 TPH2
17 alcohol-induced mental disorder 10.4 DRD2 SLC6A3
18 impulse control disorder 10.4 DRD2 DRD4 SLITRK1
19 striatonigral degeneration 10.4 DRD2 SLC6A3
20 tardive dyskinesia 10.3 DRD2 HTR2A
21 periodic limb movement disorder 10.2 DRD2 HTR2A
22 drug-induced mental disorder 10.1 DRD2 HTR2A
23 drug psychosis 10.1 DRD2 HTR2A
24 cocaine abuse 10.1 DRD2 SLC18A2 SLC6A3
25 anxiety 10.1
26 bruxism 10.0 DRD2 HTR2A
27 specific developmental disorder 10.0 DRD4 DRD5 SLC6A3
28 cranio-facial dystonia 10.0 DRD5 HTR2A
29 trichotillomania 10.0
30 alcoholic psychosis 9.9 DRD2 HTR2A SLC6A3
31 autism spectrum disorder 9.9
32 neuronitis 9.9
33 encephalopathy 9.9
34 tobacco addiction 9.8 DRD2 HTR2A SLC6A3
35 separation anxiety disorder 9.8 DRD4 SLC6A3
36 lymphedema, hereditary, ii 9.8 DRD5 HTR2A
37 substance dependence 9.7 DRD2 DRD4 DRD5 SLC6A3
38 multiple sclerosis 9.7
39 huntington disease 9.7
40 rheumatic fever-related antigen 9.7
41 fragile x syndrome 9.7
42 aging 9.7
43 motor neuron disease 9.7
44 restless legs syndrome 9.7
45 primary progressive multiple sclerosis 9.7
46 migraine with aura 9.7
47 common cold 9.7
48 arteriovenous malformation 9.7
49 rheumatic fever 9.7
50 epilepsy 9.7

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to Tic Disorder

Symptoms & Phenotypes for Tic Disorder

UMLS symptoms related to Tic Disorder:


symptoms, recurrent muscle twitches (symptom), ataxia, athetosis, dystonia, myoclonus, tremor, synkinesis, tic, gestural, tic, transient, tic, motor, tic, vocal

MGI Mouse Phenotypes related to Tic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 TDO2 TPH2 DRD2 DRD4 DRD5 HDC
2 nervous system MP:0003631 9.65 SLITRK1 TDO2 TPH2 DRD2 DRD4 DRD5
3 taste/olfaction MP:0005394 8.92 TPH2 DRD2 SLC18A2 SLC6A3

Drugs & Therapeutics for Tic Disorder

Drugs for Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 347)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
2
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
3
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
4
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 113775-47-6 68602 5311068
5
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
6
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
7
Clonidine Approved Phase 4 4205-90-7 2803
8
Aripiprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 129722-12-9 60795
9
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
10
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
11
Methylphenidate Approved, Investigational Phase 4,Phase 3,Not Applicable 113-45-1 4158
12
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
13 Piracetam Approved, Investigational Phase 4 7491-74-9
14
Guanfacine Approved, Investigational Phase 4,Phase 3 29110-47-2 3519
15
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
16
Methyltestosterone Approved Phase 4 58-18-4 6010
17
Testosterone Approved, Investigational Phase 4 58-22-0 6013
18
Testosterone enanthate Approved Phase 4 315-37-7 9416
19
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
20
Dexlansoprazole Approved, Investigational Phase 4,Phase 3 138530-94-6, 103577-45-3 9578005
21
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
22
Lansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3 3883
23
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
24
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
25
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
26
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
27
Haloperidol Approved Phase 4,Phase 3 52-86-8 3559
28
Amlodipine Approved Phase 4 88150-42-9 2162
29
Budesonide Approved Phase 4 51333-22-3 63006 5281004
30
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
31
Codeine Approved, Illicit Phase 4 76-57-3 5284371
32
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
33
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
34
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 437-38-7 3345
35
Nitrous oxide Approved, Vet_approved Phase 4,Not Applicable 10024-97-2 948
36
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
37
Sufentanil Approved, Investigational Phase 4,Phase 3,Not Applicable 56030-54-7 41693
38
Cycloserine Approved Phase 4,Not Applicable 68-41-7 401 6234
39
Flurbiprofen Approved, Investigational Phase 4,Phase 1 5104-49-4 3394
40
Midazolam Approved, Illicit Phase 4,Phase 3,Not Applicable 59467-70-8 4192
41
Acetylcysteine Approved, Investigational Phase 4,Phase 2 616-91-1 12035
42
Ondansetron Approved Phase 4 99614-02-5 4595
43
Cefdinir Approved Phase 4 91832-40-5 6915944
44
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
45
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
46
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
47
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
48
Fluticasone Approved, Experimental, Investigational Phase 4 90566-53-3 62924
49
Doxofylline Approved, Investigational Phase 4 69975-86-6
50
Theophylline Approved Phase 4 58-55-9 2153

Interventional clinical trials:

(show top 50) (show all 353)
# Name Status NCT ID Phase Drugs
1 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Unknown status NCT02457130 Phase 4 Ticagrelor;Clopidogrel
2 Long Term Postoperative Cognitive Dysfunction in the Elderly Patients Unknown status NCT02301676 Phase 4 Sevoflurane;propofol
3 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
4 Comparison of Keppra and Clonidine in the Treatment of Tics Completed NCT00370838 Phase 4 Levetiracetam;Clonidine
5 Guanfacine in Children With Tic Disorders Completed NCT01547000 Phase 4 placebo;extended-release guanfacine (Intuniv)
6 Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT00241176 Phase 4 Aripiprazole
7 Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission Completed NCT01018056 Phase 4 D-serine;Riluzole;Placebo
8 Benefit of the Treatment With Testosterone in Chronic Heart Failure Testosterone Deficiency Subjects Completed NCT01813201 Phase 4 Testosterone undecanoate;Saline isotonic solution
9 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4 Amoxicillin
10 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
11 Comparison of 24 Hour Bronchodilator Efficacy of Tiotropium 18 mcg Delivered Via DISCAIR Versus SPIRIVA 18 µg Delivered Via HANDIHALER® in Patients With Moderate to Severe COPD Completed NCT02541006 Phase 4 Tiotropium 18 mcg
12 The Efficacy of Lansoprazole and Domperidone Combination on Intragastric and Intraesophageal Acidity Completed NCT02958046 Phase 4 Lansoprazole/Domperidone
13 Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients Completed NCT02275182 Phase 4 Dexmedetomidine;Saline
14 Controlled Hypotension During Functional Endoscopic Sinus Surgery Completed NCT01956981 Phase 4 Magnesium Sulfate;Dexmedetomidine
15 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4 Olanzapine
16 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4 olanzapine + fluoxetine;placebo + fluoxetine
17 Efficacy and Safety of S-amlodipine 2,5 mg and 5 mg in Hypertension Patients Completed NCT03038451 Phase 4 S-NOR (s-amlodipine) 2,5 mg & 5 mg tablet
18 Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD Completed NCT03028701 Phase 4 Formoterol/Budesonide 12/400 mcg Discair
19 Tiotropium/Formoterol Via Discair® vs Tiotropium Monotherapy or Tiotropium + Formoterol Free Combination Treatment Completed NCT02988869 Phase 4 Tiotropium/Formoterol;Tiotropium;Formoterol;Tiotropium
20 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
21 The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity Completed NCT02689999 Phase 4 Dexrabeprazole 10 mg Enteric-Coated Tablets
22 Efficacy and Safety of Imuneks 10 mg Capsules in the Prophylaxis of Cold Completed NCT02807220 Phase 4 Imuneks 10mg
23 Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children Completed NCT00183391 Phase 4 Atomoxetine;Methylphenidate
24 Dexmedetomidine and Delirium in Patients After Cardiac Surgery Completed NCT02267538 Phase 4 dexmedetomidine hydrochloride for injection;0.9% sodium chloride for injection
25 Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis Completed NCT02501564 Phase 4 Naproxen Sodium Codeine;Placebo
26 Dexmedetomidine and Long-term Outcome in Elderly Patients After Surgery Completed NCT02809937 Phase 4 dexmedetomidine;placebo
27 Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium Completed NCT02662257 Phase 4 Sevoflurane;Propofol
28 Dexmedetomidine and Long-term Outcomes in Elderly Patients After Cardiac Surgery Completed NCT03289325 Phase 4 dexmedetomidine hydrochloride for injection;0.9% sodium chloride for injection
29 Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity Completed NCT01863459 Phase 4 Lisdexamfetamine Dimesylate;placebo
30 D-Cycloserine as an Adjunct to Internet-CBT for OCD Completed NCT01649895 Phase 4 D-Cycloserine;Placebo
31 Effects of Ondansetron in Obsessive-compulsive and Tic Disorders Recruiting NCT03239210 Phase 4 Ondansetron;Placebo
32 Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Adults Recruiting NCT03400735 Phase 4 Cefdinir 300Mg Capsule
33 The Safety of Dapoxetine/Tadalafil Combination Therapy Recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
34 Comparison of the Effect of Rabeprazole 50 mg DDR Capsules and 20 mg Enteric-coated Tablets Recruiting NCT03037606 Phase 4 Rabelis DDR 50 mg Capsules;Pariet 20 mg Enteric Coated Tablets
35 Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery Recruiting NCT03172988 Phase 4 Dexamethasone;Normal saline;Flurbiprofen axetil;Lipid microsphere
36 Dexmedetomidine Supplemented Analgesia and 2-Year Survival After Cancer Surgery Recruiting NCT03012971 Phase 4 Dexmedetomidine supplemented morphine analgesia;Morphine analgesia
37 Dexmedetomidine Supplemented Analgesia and Incidence of Postoperative Delirium Recruiting NCT03012984 Phase 4 Dexmedetomidine supplemented morphine analgesia;Morphine analgesia
38 Dexamethasone, Flurbiprofen Axetil and Delirium After Lung Cancer Surgery Recruiting NCT03200600 Phase 4 Dexamethasone;Normal saline;Flurbiprofen axetil;Lipid microsphere
39 Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients Recruiting NCT03172897 Phase 4 Dexmedetomidine;Placebo (normal saline)
40 Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients Recruiting NCT03335527 Phase 4 Dexmedetomidine;Placebo (normal saline)
41 A Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Active, not recruiting NCT03348618 Phase 4
42 Impact of Anesthesia Maintenance Methods on Long-term Survival Rate Active, not recruiting NCT02660411 Phase 4 Sevoflurane;Propofol
43 Tiotropium/Salmeterol/Fluticasone Fixed Dose Combination Tratment Via Discair vs Tiotropium Via Handihaler + Salmeterol/Fluticasone Via Diskus Free Combination Treatment Not yet recruiting NCT03395002 Phase 4 Tiotropium/Salmeterol/Fluticasone 9/50/500 mcg Inhalation Powder;Tiotropium 18 mcg Inhalation Powder;Salmeterol/Fluticasone 50/500 mcg Inhalation Powder
44 Efficacy and Safety Study of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet in the Treatment of Moderate-Severe COPD. Not yet recruiting NCT03388853 Phase 4 Acetylcysteine/Doxofylline
45 Salmeterol/Fluticasone 50/500 mcg Inhalation Powder Via Capsair vs Seretide Diskus 500 mcg Inhalation Powder in Patients With COPD Not yet recruiting NCT03363503 Phase 4 Salmeterol/Fluticasone Capsair®;Salmeterol/Fluticasone Diskus®
46 Cardiac Safety of Lansoprazole and Domperidon Combination Not yet recruiting NCT03355170 Phase 4 Lansoprazole
47 Safety Study of Galantamine in Tic Disorders Terminated NCT00226824 Phase 4 galantamine
48 Intravenous Immunoglobulin for PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated With Streptococcal Infections) Unknown status NCT01281969 Phase 3 Gamunex Intravenous Immunoglobulin;Placebo
49 Cognitive Behavior Therapy and Habit Reversal Training for the Treatment of Chronic Tic Disorders in Children Completed NCT00218777 Phase 2, Phase 3
50 Phase III Study of 5LGr to Treat Tic Disorder Completed NCT01501695 Phase 3 5LGr;tiapride;placebo

Search NIH Clinical Center for Tic Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Tic Disorder

Genetic tests related to Tic Disorder:

# Genetic test Affiliating Genes
1 Tics 29

Anatomical Context for Tic Disorder

MalaCards organs/tissues related to Tic Disorder:

41
Brain, Testes, Heart, Lung, Globus Pallidus, Thalamus, Liver

Publications for Tic Disorder

Articles related to Tic Disorder:

(show top 50) (show all 162)
# Title Authors Year
1
A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome. ( 29636706 )
2018
2
Pharmacological treatment for attention deficit hyperactivity disorder (ADHD) in children with comorbid tic disorders. ( 29944175 )
2018
3
Tic Disorders and PANDAS. ( 29735114 )
2018
4
Chronic tic disorders in children with ADHD. ( 29317441 )
2018
5
Seroprevalance Anti-Toxoplasma gondii antibodies in children and adolescents with tourette syndrome/chronic motor or vocal tic disorder: A case-control study. ( 29554545 )
2018
6
Misophonia in Children with Tic Disorders: A Case Series. ( 29553971 )
2018
7
Tourette Syndrome and Chronic Tic Disorders: The Clinical Spectrum Beyond Tics. ( 28805580 )
2017
8
Adult-onset pure tic disorder after post-traumatic hypoxic lesions of the globus pallidus. ( 27887894 )
2017
9
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
10
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
11
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
12
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
13
Chronic recurrent dislocation of the temporomandibular joint secondary to a complex facial tic disorder. ( 29017736 )
2017
14
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. ( 28894297 )
2017
15
Pediatric Tourette Syndrome: A Tic Disorder with a Tricky Presentation. ( 28611559 )
2017
16
Parsing the phenotype of obsessive-compulsive tic disorder (OCTD): a multidisciplinary consensus. ( 28379724 )
2017
17
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
18
Twice-weekly aripiprazole for treating children and adolescents with tic disorder, a randomized controlled clinical trial. ( 27579050 )
2016
19
The effects of Gilles de la Tourette syndrome and other chronic tic disorders on quality of life across the lifespan: a systematic review. ( 26880181 )
2016
20
Provisional Tic Disorder: What to tell parents when their child first starts ticcing. ( 27158458 )
2016
21
Atomoxetine Use in Attention-Deficit/Hyperactivity Disorder and Comorbid Tic Disorder in Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. ( 27315236 )
2016
22
Late onset tic disorder: A rare occurrence. ( 26310263 )
2015
23
Thimerosal exposure and increased risk for diagnosed tic disorder in the United States: a case-control study. ( 27486363 )
2015
24
A Case of Atypical Adult-onset Tic Disorder. ( 25888196 )
2015
25
Electrophysiological similarities in Tourette syndrome and chronic tic disorder. ( 26531497 )
2015
26
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
27
Paroxetine-Related Adult-Onset Tic Disorder: A Presentation of Primary Progressive Multiple Sclerosis. ( 26222974 )
2015
28
Clinical Characteristics of Pediatric Trichotillomania: Comparisons with Obsessive-Compulsive and Tic Disorders. ( 25894516 )
2015
29
Relationships between Premonitory Urge and Anxiety in Youth with Chronic Tic Disorders. ( 27110050 )
2015
30
Evaluation of cognitive behaviour therapy for paediatric obsessive-compulsive disorder in the context of tic disorders. ( 25843610 )
2015
31
Atomoxetine-induced mania with auditory hallucination in an 8-year-old boy with attention-deficit/hyperactivity disorder and tic disorder. ( 25020072 )
2014
32
Tic disorder probably associated with steroid responsive encephalopathy with autoimmune thyroiditis (SREAT). ( 24633901 )
2014
33
A guide to childhood motor stereotypies, tic disorders and the tourette spectrum for the primary care practitioner. ( 24757265 )
2014
34
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
35
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
36
Reward enhances tic suppression in children within months of tic disorder onset. ( 25220075 )
2014
37
Mindfulness-based stress reduction for Tourette syndrome and chronic tic disorder: A pilot study. ( 25149879 )
2014
38
Post-operative Adult Onset Tic Disorder: A Rare Presentation. ( 25336779 )
2014
39
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
40
Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population. ( 23360517 )
2013
41
Attention deficit hyperactivity disorder, tic disorder, and allergy: is there a link? A nationwide population-based study. ( 23140273 )
2013
42
Clinical Effectiveness of Aripiprazole in Short-term Treatment of Tic Disorder in Children and Adolescents: A Naturalistic Study. ( 23920131 )
2013
43
Prevalence and comorbidity of tic disorder in Israeli adolescents: results from a national mental health survey. ( 23516770 )
2013
44
A case of early-onset obsessive-compulsive disorder with musical obsessions and comorbid tic disorder. ( 23487208 )
2013
45
Aripiprazole Versus Risperidone for Treating Children and Adolescents with Tic Disorder: A Randomized Double Blind Clinical Trial. ( 24343476 )
2013
46
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
47
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
48
The future of tic disorder treatment. ( 24175754 )
2013
49
Tremor in neurodegenerative ataxias, Huntington disease and tic disorder. ( 23821420 )
2013
50
Youths with ADHD with and without tic disorders: comorbid psychopathology, executive function and social adjustment. ( 22285732 )
2012

Variations for Tic Disorder

ClinVar genetic disease variations for Tic Disorder:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 Translocation Likely pathogenic
2 46;XY;t(3;18)(q13.31;q22.1)dn Translocation Pathogenic

Expression for Tic Disorder

Search GEO for disease gene expression data for Tic Disorder.

Pathways for Tic Disorder

Pathways related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 DRD2 DRD4 DRD5 SLC18A2 SLC6A3
2
Show member pathways
11.87 DRD2 DRD4 DRD5
3 11.85 HSPD1 HTR2A TPH2
4
Show member pathways
11.61 DRD2 SLC18A2 SLC6A3
5 11.55 HTR2A SLC18A2 TPH2
6
Show member pathways
11.44 DRD2 DRD4 SLC18A2
7
Show member pathways
10.98 DRD2 DRD4 DRD5 HTR2A
8 10.97 SLC18A2 SLC6A3
9
Show member pathways
10.97 SLC6A3 TDO2 TPH2
10 10.78 DRD2 DRD5
11 10.58 HTR2A SLC18A2 TPH2

GO Terms for Tic Disorder

Cellular components related to Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.43 DRD2 DRD4 DRD5 HTR2A SLC18A2 SLC6A3
2 non-motile cilium GO:0097730 8.62 DRD2 DRD5

Biological processes related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 cellular calcium ion homeostasis GO:0006874 9.71 DRD4 DRD5 HTR2A
2 locomotory behavior GO:0007626 9.69 DRD2 SLC18A2 SLC6A3
3 positive regulation of multicellular organism growth GO:0040018 9.64 DRD2 SLC6A3
4 associative learning GO:0008306 9.64 DRD2 DRD5
5 negative regulation of blood pressure GO:0045776 9.63 DRD2 DRD5
6 adult behavior GO:0030534 9.63 DRD2 SLITRK1
7 arachidonic acid secretion GO:0050482 9.62 DRD2 DRD4
8 regulation of dopamine secretion GO:0014059 9.62 DRD2 HTR2A
9 temperature homeostasis GO:0001659 9.61 DRD2 HTR2A
10 synaptic transmission, dopaminergic GO:0001963 9.61 DRD2 DRD5
11 response to iron ion GO:0010039 9.6 DRD2 SLC6A3
12 negative regulation of protein secretion GO:0050709 9.59 DRD2 DRD4
13 behavioral response to ethanol GO:0048149 9.58 DRD2 DRD4
14 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.58 DRD2 HTR2A
15 dopamine metabolic process GO:0042417 9.57 DRD2 DRD4
16 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.56 DRD2 DRD5
17 negative regulation of voltage-gated calcium channel activity GO:1901386 9.55 DRD2 DRD4
18 prepulse inhibition GO:0060134 9.52 DRD2 SLC6A3
19 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.49 DRD2 DRD4
20 regulation of dopamine metabolic process GO:0042053 9.48 DRD4 SLC6A3
21 monoamine transport GO:0015844 9.46 SLC18A2 SLC6A3
22 adenohypophysis development GO:0021984 9.43 DRD2 SLC6A3
23 response to cocaine GO:0042220 9.43 DRD2 DRD5 SLC6A3
24 dopamine transport GO:0015872 9.4 SLC18A2 SLC6A3
25 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.37 DRD2 DRD4
26 behavioral response to cocaine GO:0048148 9.33 DRD2 DRD4 HTR2A
27 response to histamine GO:0034776 9.32 DRD2 DRD4
28 dopamine receptor signaling pathway GO:0007212 9.13 DRD2 DRD4 DRD5
29 response to amphetamine GO:0001975 8.92 DRD2 DRD4 DRD5 SLC18A2

Molecular functions related to Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer activity GO:0004871 9.67 DRD2 DRD4 DRD5 HTR2A
2 drug binding GO:0008144 9.46 DRD2 DRD4 HTR2A SLC6A3
3 G-protein alpha-subunit binding GO:0001965 9.4 DRD5 HTR2A
4 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.32 DRD2 DRD4
5 monoamine transmembrane transporter activity GO:0008504 9.26 SLC18A2 SLC6A3
6 dopamine neurotransmitter receptor activity GO:0004952 9.13 DRD2 DRD4 DRD5
7 dopamine binding GO:0035240 8.92 DRD2 DRD4 DRD5 SLC6A3

Sources for Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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