Aliases & Classifications for Tic Disorder

MalaCards integrated aliases for Tic Disorder:

Name: Tic Disorder 12 15 74
Behavioral Tic 74
Tics 6

Classifications:



External Ids:

Disease Ontology 12 DOID:2769
ICD9CM 36 307.2 307.20
MeSH 45 D013981
SNOMED-CT 69 35042001 568005
ICD10 34 F95 F95.9

Summaries for Tic Disorder

Disease Ontology : 12 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards based summary : Tic Disorder, also known as behavioral tic, is related to gilles de la tourette syndrome and tardive dyskinesia, and has symptoms including ataxia, tremor and myoclonus. An important gene associated with Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Circadian entrainment and Beta-Adrenergic Signaling. The drugs Clopidogrel and Ticagrelor have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and kidney, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 77 Tic disorders is defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Related Diseases for Tic Disorder

Diseases in the Tic Disorder family:

Chronic Tic Disorder Transient Tic Disorder

Diseases related to Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 gilles de la tourette syndrome 32.3 DRD2 DRD4 DRD5 HDC IMMP2L SLC6A3
2 tardive dyskinesia 30.2 DRD2 DRD3
3 early-onset schizophrenia 30.0 DRD1 DRD2
4 migraine with or without aura 1 29.9 DRD2 DRD3 DRD5
5 choreatic disease 29.8 PNKD SLC18A2
6 obsessive-compulsive disorder 29.7 DRD1 DRD2 DRD3 DRD4 SLC6A3 SLITRK1
7 restless legs syndrome 29.6 DRD2 DRD3 SLC6A3
8 oppositional defiant disorder 29.6 DRD2 DRD4 SLC6A3 TPH2
9 conduct disorder 29.5 DRD2 DRD4 DRD5 SLC6A3
10 dystonia 29.3 DRD2 DRD5 PNKD SLC6A3
11 movement disease 29.2 DRD2 DRD3 SLC18A2 SLC6A3
12 bipolar disorder 29.0 DRD2 DRD3 SLC18A2 SLC6A3
13 disease of mental health 29.0 DRD2 DRD3 DRD4 NRXN1 SLC6A3
14 attention deficit-hyperactivity disorder 28.4 DRD1 DRD2 DRD3 DRD4 DRD5 IMMP2L
15 schizophrenia 28.1 DRD1 DRD2 DRD3 DRD4 DRD5 NRXN1
16 chronic tic disorder 12.8
17 transient tic disorder 12.7
18 trigeminal neuralgia 12.1
19 pediatric acute-onset neuropsychiatric syndrome 11.3
20 chorea, benign hereditary 11.2
21 ceroid lipofuscinosis, neuronal, 4b, autosomal dominant 11.0
22 convulsions, familial infantile, with paroxysmal choreoathetosis 11.0
23 cerebral creatine deficiency syndrome 2 11.0
24 adult neuronal ceroid lipofuscinosis 11.0
25 coasy protein-associated neurodegeneration 11.0
26 pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections 11.0
27 pol iii-related leukodystrophies 10.6
28 tylosis with esophageal cancer 10.3
29 anxiety 10.3
30 intraocular pressure quantitative trait locus 10.2
31 stuttering 10.2
32 paroxysmal hemicrania 10.2
33 hemifacial spasm 10.2
34 myoclonus 10.2
35 polysubstance abuse 10.2 DRD2 DRD3
36 delusional disorder 10.2 DRD2 DRD3 DRD4
37 migraine without aura 10.1 DRD2 DRD3 DRD4
38 heroin dependence 10.1 DRD2 DRD4
39 bruxism 10.1 DRD2 DRD3 DRD5
40 trichotillomania 10.1
41 pervasive developmental disorder 10.0
42 dementia 10.0
43 primary orthostatic tremor 10.0
44 impulse control disorder 10.0 DRD2 DRD3 DRD4 SLITRK1
45 alcohol-induced mental disorder 10.0 DRD2 SLC6A3
46 facial spasm 10.0
47 blepharospasm 10.0
48 headache 10.0
49 autoimmune disease 10.0
50 autism 10.0

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to Tic Disorder

Symptoms & Phenotypes for Tic Disorder

UMLS symptoms related to Tic Disorder:


ataxia, tremor, myoclonus, dystonia, athetosis, symptoms, synkinesis, recurrent muscle twitches (symptom), tic, motor, tic, gestural, tic, transient, tic, vocal

MGI Mouse Phenotypes related to Tic Disorder:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.25 DRD1 DRD2 DRD3 DRD4 DRD5 HDC
2 growth/size/body region MP:0005378 10.11 DRD1 DRD2 DRD3 HDC HSPD1 IMMP2L
3 homeostasis/metabolism MP:0005376 10.1 DRD1 DRD2 DRD3 DRD4 HDC NRXN1
4 mortality/aging MP:0010768 9.9 DRD1 DRD2 DRD3 DRD5 HSPD1 IMMP2L
5 integument MP:0010771 9.8 DRD1 DRD2 HDC IMMP2L SLC6A3 TDO2
6 nervous system MP:0003631 9.8 DRD1 DRD2 DRD3 DRD4 DRD5 HDC
7 taste/olfaction MP:0005394 8.92 DRD2 SLC18A2 SLC6A3 TPH2

Drugs & Therapeutics for Tic Disorder

Drugs for Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 380)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clopidogrel Approved Phase 4,Phase 3 120202-66-6, 113665-84-2 60606
2
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
3
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
4
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Early Phase 1,Not Applicable 113775-47-6 5311068 68602
5
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
6
Clonidine Approved Phase 4 4205-90-7 2803
7
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 62-31-7, 51-61-6 681
8
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
9
Methylphenidate Approved, Investigational Phase 4,Phase 3,Not Applicable 113-45-1 4158
10
Naproxen Approved, Vet_approved Phase 4 22204-53-1 156391 1302
11
Levetiracetam Approved, Investigational Phase 4 102767-28-2 441341
12
Guanfacine Approved, Investigational Phase 4,Phase 3 29110-47-2 3519
13
Aripiprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 129722-12-9 60795
14
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
15
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013
16
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
17
Methyltestosterone Approved Phase 4 58-18-4 6010
18
Testosterone enanthate Approved Phase 4 315-37-7 9416
19
Lansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3 3883
20
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
21
Dexlansoprazole Approved, Investigational Phase 4,Phase 3 138530-94-6, 103577-45-3 9578005
22
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
23
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
24
Haloperidol Approved Phase 4,Phase 3 52-86-8 3559
25
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
26
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 5324346 3404
27
Amlodipine Approved Phase 4 88150-42-9 2162
28
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
29
Budesonide Approved Phase 4 51333-22-3 5281004 63006
30
Sodium Citrate Approved, Investigational Phase 4 68-04-2
31
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
32
Codeine Approved, Illicit Phase 4 76-57-3 5284371
33
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
34
tannic acid Approved Phase 4,Not Applicable 1401-55-4
35
Sufentanil Approved, Investigational Phase 4,Phase 3,Not Applicable,Early Phase 1 56030-54-7 41693
36
Nitrous oxide Approved, Vet_approved Phase 4,Not Applicable 10024-97-2 948
37
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
38
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 437-38-7 3345
39
Cycloserine Approved Phase 4,Not Applicable 68-41-7 6234 401
40
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
41
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273
42
Midazolam Approved, Illicit Phase 4,Phase 3,Not Applicable 59467-70-8 4192
43
Rocuronium Approved Phase 4,Not Applicable 119302-91-9, 143558-00-3 441290
44
Acetylcysteine Approved, Investigational Phase 4,Phase 2 616-91-1 12035
45
Pseudoephedrine Approved Phase 4,Phase 3,Not Applicable 90-82-4 7028
46
Ephedrine Approved Phase 4,Phase 3,Not Applicable 299-42-3 9294
47
Flurbiprofen Approved, Investigational Phase 4,Phase 1 5104-49-4 3394
48
Ondansetron Approved Phase 4 99614-02-5 4595
49
Cefdinir Approved Phase 4 91832-40-5 6915944
50
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924

Interventional clinical trials:

(show top 50) (show all 407)
# Name Status NCT ID Phase Drugs
1 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Unknown status NCT02457130 Phase 4 Ticagrelor;Clopidogrel
2 Long Term Postoperative Cognitive Dysfunction in the Elderly Patients Unknown status NCT02301676 Phase 4 Sevoflurane;propofol
3 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
4 Comparison of Keppra and Clonidine in the Treatment of Tics Completed NCT00370838 Phase 4 Levetiracetam;Clonidine
5 Guanfacine in Children With Tic Disorders Completed NCT01547000 Phase 4 placebo;extended-release guanfacine (Intuniv)
6 Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT00241176 Phase 4 Aripiprazole
7 Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission Completed NCT01018056 Phase 4 D-serine;Riluzole;Placebo
8 Benefit of the Treatment With Testosterone in Chronic Heart Failure Testosterone Deficiency Subjects Completed NCT01813201 Phase 4 Testosterone undecanoate;Saline isotonic solution
9 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4 Amoxicillin
10 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
11 Comparison of 24 Hour Bronchodilator Efficacy of Tiotropium 18 mcg Delivered Via DISCAIR Versus SPIRIVA 18 µg Delivered Via HANDIHALER® in Patients With Moderate to Severe COPD Completed NCT02541006 Phase 4 Tiotropium 18 mcg
12 The Efficacy of Lansoprazole and Domperidone Combination on Intragastric and Intraesophageal Acidity Completed NCT02958046 Phase 4 Lansoprazole/Domperidone
13 Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients Completed NCT02275182 Phase 4 Dexmedetomidine;Saline
14 Controlled Hypotension During Functional Endoscopic Sinus Surgery Completed NCT01956981 Phase 4 Magnesium Sulfate;Dexmedetomidine
15 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4 Olanzapine
16 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4 olanzapine + fluoxetine;placebo + fluoxetine
17 Efficacy and Safety of S-amlodipine 2,5 mg and 5 mg in Hypertension Patients Completed NCT03038451 Phase 4 S-NOR (s-amlodipine) 2,5 mg & 5 mg tablet
18 Comparison of the Effect of Rabeprazole 50 mg DDR Capsules and 20 mg Enteric-coated Tablets Completed NCT03037606 Phase 4 Rabelis DDR 50 mg Capsules;Pariet 20 mg Enteric Coated Tablets
19 Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD Completed NCT03028701 Phase 4 Formoterol/Budesonide 12/400 mcg Discair
20 Tiotropium/Formoterol Via Discair® vs Tiotropium Monotherapy or Tiotropium + Formoterol Free Combination Treatment Completed NCT02988869 Phase 4 Tiotropium/Formoterol;Tiotropium;Formoterol;Tiotropium
21 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
22 The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity Completed NCT02689999 Phase 4 Dexrabeprazole 10 mg Enteric-Coated Tablets
23 Efficacy and Safety of Imuneks 10 mg Capsules in the Prophylaxis of Cold Completed NCT02807220 Phase 4 Imuneks 10mg
24 Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children Completed NCT00183391 Phase 4 Atomoxetine;Methylphenidate
25 Dexmedetomidine and Delirium in Patients After Cardiac Surgery Completed NCT02267538 Phase 4 dexmedetomidine hydrochloride for injection;0.9% sodium chloride for injection
26 Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis Completed NCT02501564 Phase 4 Naproxen Sodium Codeine;Placebo
27 Dexmedetomidine and Long-term Outcome in Elderly Patients After Surgery Completed NCT02809937 Phase 4 dexmedetomidine;placebo
28 Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium Completed NCT02662257 Phase 4 Sevoflurane;Propofol
29 Dexmedetomidine and Long-term Outcomes in Elderly Patients After Cardiac Surgery Completed NCT03289325 Phase 4 dexmedetomidine hydrochloride for injection;0.9% sodium chloride for injection
30 Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity Completed NCT01863459 Phase 4 Lisdexamfetamine Dimesylate;placebo
31 D-Cycloserine as an Adjunct to Internet-CBT for OCD Completed NCT01649895 Phase 4 D-Cycloserine;Placebo
32 Effects of Ondansetron in Obsessive-compulsive and Tic Disorders Recruiting NCT03239210 Phase 4 Ondansetron;Placebo
33 Trial to Evaluate the Long-term Efficacy of Oral Aripiprazole in the Treatment of Pediatric Subjects With Tourette's Disorder Recruiting NCT03661983 Phase 4 Aripiprazole (OPC-14597);Placebo
34 Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Adults Recruiting NCT03400735 Phase 4 Cefdinir 300Mg Capsule
35 Tiotropium/Salmeterol/Fluticasone Fixed Dose Combination Tratment Via Discair vs Tiotropium Via Handihaler + Salmeterol/Fluticasone Via Diskus Free Combination Treatment Recruiting NCT03395002 Phase 4 Tiotropium/Salmeterol/Fluticasone 9/50/500 mcg Inhalation Powder;Tiotropium 18 mcg Inhalation Powder;Salmeterol/Fluticasone 50/500 mcg Inhalation Powder
36 The Safety of Dapoxetine/Tadalafil Combination Therapy Recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
37 The Effect of Ramelteon on Delirium and Sleep in Patients Admitted to the ICU Recruiting NCT03931070 Phase 4 Ramelteon;Placebo - Cap
38 Dexmedetomidine Supplemented Analgesia and 2-Year Survival After Cancer Surgery Recruiting NCT03012971 Phase 4 Dexmedetomidine supplemented morphine analgesia;Morphine analgesia
39 Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery Recruiting NCT03629262 Phase 4 Dexmedetomidine;Placebo
40 Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block Recruiting NCT03629483 Phase 4 Dexmedetomidine;Placebo
41 Dexmedetomidine Supplemented Analgesia and Incidence of Postoperative Delirium Recruiting NCT03012984 Phase 4 Dexmedetomidine supplemented morphine analgesia;Morphine analgesia
42 Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients Recruiting NCT03172897 Phase 4 Dexmedetomidine;Placebo (normal saline)
43 Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients Recruiting NCT03335527 Phase 4 Dexmedetomidine;Placebo (normal saline)
44 Low-dose Dexmedetomidine and Postoperative Delirium After Cardiac Surgery Recruiting NCT03624595 Phase 4 Dexmedetomidine;Placebo
45 A Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Active, not recruiting NCT03348618 Phase 4
46 Impact of Anesthesia Maintenance Methods on Long-term Survival Rate Active, not recruiting NCT02660411 Phase 4 Sevoflurane;Propofol
47 Prophylactic Penehyclidine Hydrochloride Inhalation and 3-year Outcome After Surgery Active, not recruiting NCT03868709 Phase 4 Penehyclidine inhalation;Placebo inhalation
48 Evaluation of the Contribution of Regular Cognitive Exercises to Treatment in Patients With Alzheimer's Disease Not yet recruiting NCT03954613 Phase 4
49 Efficacy and Safety Study of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet in the Treatment of Moderate-Severe COPD. Not yet recruiting NCT03388853 Phase 4 Acetylcysteine/Doxofylline
50 Salmeterol/Fluticasone 50/500 mcg Inhalation Powder Via Capsair vs Seretide Diskus 500 mcg Inhalation Powder in Patients With COPD Not yet recruiting NCT03363503 Phase 4 Salmeterol/Fluticasone Capsair®;Salmeterol/Fluticasone Diskus®

Search NIH Clinical Center for Tic Disorder

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Tic Disorder

Anatomical Context for Tic Disorder

MalaCards organs/tissues related to Tic Disorder:

42
Brain, Testes, Kidney, Lymph Node, Cortex, Thyroid, Globus Pallidus

Publications for Tic Disorder

Articles related to Tic Disorder:

(show top 50) (show all 140)
# Title Authors Year
1
Association of Tourette Syndrome and Chronic Tic Disorder With Metabolic and Cardiovascular Disorders. ( 30640363 )
2019
2
Bupropion-Related Exacerbation of Tic Disorder in an Adult: A Case Report. ( 30499776 )
2019
3
An exploratory study into an adapted use of the Alert Program for tic disorder in children. ( 30501513 )
2019
4
Provisional Tic Disorder is not so transient. ( 30850688 )
2019
5
A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome. ( 29636706 )
2018
6
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. ( 28894297 )
2018
7
Seroprevalance Anti-Toxoplasma gondii antibodies in children and adolescents with tourette syndrome/chronic motor or vocal tic disorder: A case-control study. ( 29554545 )
2018
8
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
9
Atomoxetine Use in Attention-Deficit/Hyperactivity Disorder and Comorbid Tic Disorder in Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. ( 27315236 )
2017
10
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
11
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
12
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
13
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
14
Adult-onset pure tic disorder after post-traumatic hypoxic lesions of the globus pallidus. ( 27887894 )
2017
15
Parsing the phenotype of obsessive-compulsive tic disorder (OCTD): a multidisciplinary consensus. ( 28379724 )
2017
16
Pediatric Tourette Syndrome: A Tic Disorder with a Tricky Presentation. ( 28611559 )
2017
17
Chronic recurrent dislocation of the temporomandibular joint secondary to a complex facial tic disorder. ( 29017736 )
2017
18
Provisional Tic Disorder: What to tell parents when their child first starts ticcing. ( 27158458 )
2016
19
Twice-weekly aripiprazole for treating children and adolescents with tic disorder, a randomized controlled clinical trial. ( 27579050 )
2016
20
Mindfulness-based stress reduction for Tourette Syndrome and Chronic Tic Disorder: a pilot study. ( 25149879 )
2015
21
Validity and reliability of chronic tic disorder and obsessive-compulsive disorder diagnoses in the Swedish National Patient Register. ( 26100027 )
2015
22
Paroxetine-Related Adult-Onset Tic Disorder: A Presentation of Primary Progressive Multiple Sclerosis. ( 26222974 )
2015
23
Reward enhances tic suppression in children within months of tic disorder onset. ( 25220075 )
2015
24
A case of atypical adult-onset tic disorder. ( 25888196 )
2015
25
Late onset tic disorder: A rare occurrence. ( 26310263 )
2015
26
Thimerosal exposure and increased risk for diagnosed tic disorder in the United States: a case-control study. ( 27486363 )
2015
27
Tourette syndrome and chronic tic disorder are associated with lower socio-economic status: findings from the Avon Longitudinal Study of Parents and Children cohort. ( 24138188 )
2014
28
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. ( 24262815 )
2014
29
Quality of life and self-esteem in children with chronic tic disorder. ( 26078684 )
2014
30
Tic disorder probably associated with steroid responsive encephalopathy with autoimmune thyroiditis (SREAT). ( 24633901 )
2014
31
Clinical effectiveness of aripiprazole in short-term treatment of tic disorder in children and adolescents: a naturalistic study. ( 23920131 )
2014
32
Aripiprazole versus risperidone for treating children and adolescents with tic disorder: a randomized double blind clinical trial. ( 24343476 )
2014
33
Atomoxetine-induced mania with auditory hallucination in an 8-year-old boy with attention-deficit/hyperactivity disorder and tic disorder. ( 25020072 )
2014
34
Post-operative Adult Onset Tic Disorder: A Rare Presentation. ( 25336779 )
2014
35
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. ( 23639924 )
2013
36
Cognitive therapy of obsessive compulsive disorder with chronic tic disorder. ( 23833351 )
2013
37
Tremor in neurodegenerative ataxias, Huntington disease and tic disorder. ( 23821420 )
2013
38
A case of early-onset obsessive-compulsive disorder with musical obsessions and comorbid tic disorder. ( 23487208 )
2013
39
Attention deficit hyperactivity disorder, tic disorder, and allergy: is there a link? A nationwide population-based study. ( 23140273 )
2013
40
Involvement of tryptophan hydroxylase 2 gene polymorphisms in susceptibility to tic disorder in Chinese Han population. ( 23360517 )
2013
41
Prevalence and comorbidity of tic disorder in Israeli adolescents: results from a national mental health survey. ( 23516770 )
2013
42
The future of tic disorder treatment. ( 24175754 )
2013
43
Isochromosome 13 in a patient with childhood-onset schizophrenia, ADHD, and motor tic disorder. ( 22214315 )
2012
44
A stimulus-sensitive tic disorder characterized by echophenomena and coprolalia. ( 21915912 )
2012
45
Exome sequencing of a pedigree with Tourette syndrome or chronic tic disorder. ( 21520241 )
2011
46
The clinical syndrome of primary tic disorder associated with dystonia: a large clinical series and a review of the literature. ( 21506147 )
2011
47
Methylphenidate and comorbid anxiety disorder in children with both chronic multiple tic disorder and ADHD. ( 20378921 )
2011
48
Patterns and correlates of tic disorder diagnoses in privately and publicly insured youth. ( 21241949 )
2011
49
Attentional performance in children and adolescents with tic disorder and co-occurring attention-deficit/hyperactivity disorder: new insights from a 2 × 2 factorial design study. ( 21331638 )
2011
50
Neurophysiological determinants of tic severity in children with chronic motor tic disorder. ( 21431421 )
2011

Variations for Tic Disorder

ClinVar genetic disease variations for Tic Disorder:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 Translocation Likely pathogenic
2 46;XY;t(3;18)(q13.31;q22.1)dn Translocation Pathogenic

Expression for Tic Disorder

Search GEO for disease gene expression data for Tic Disorder.

Pathways for Tic Disorder

Pathways related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 DRD1 DRD2 DRD3 DRD4 DRD5 SLC18A2
2
Show member pathways
12.59 DRD1 DRD2 DRD3 DRD4 DRD5
3 12.08 DRD1 DRD2 DRD3 DRD4 DRD5
4
Show member pathways
11.98 DRD1 DRD2 DRD4 DRD5
6
Show member pathways
11.77 DRD1 DRD2 SLC18A2 SLC6A3
7
Show member pathways
11.68 DRD2 DRD3 DRD4 SLC18A2
8
Show member pathways
11.4 DRD1 DRD2 DRD3 DRD4 DRD5
9 11.31 DRD1 DRD2 HSPD1
10
Show member pathways
11.24 SLC6A3 TDO2 TPH2
11 11 SLC18A2 SLC6A3
12 10.96 SLC18A2 TPH2
13 10.27 DRD1 DRD2 DRD3 DRD5

GO Terms for Tic Disorder

Cellular components related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.92 DRD1 DRD2 DRD3 DRD4 DRD5 NRXN1
2 endocytic vesicle GO:0030139 9.63 DRD2 DRD3 NRXN1
3 glutamatergic synapse GO:0098978 9.63 DRD1 DRD2 DRD3 DRD4 NRXN1 SLITRK1
4 ciliary membrane GO:0060170 9.61 DRD1 DRD2 DRD5
5 integral component of postsynaptic membrane GO:0099055 9.58 DRD1 DRD2 SLC6A3
6 integral component of presynaptic membrane GO:0099056 9.56 DRD1 DRD2 NRXN1 SLC6A3
7 non-motile cilium GO:0097730 9.54 DRD1 DRD2 DRD5
8 GABA-ergic synapse GO:0098982 9.35 DRD1 DRD2 DRD3 NRXN1 SLITRK1
9 dopaminergic synapse GO:0098691 8.92 DRD2 DRD3 SLC18A2 SLC6A3
10 membrane GO:0016020 10.29 DRD1 DRD2 DRD3 DRD4 DRD5 HSPD1
11 integral component of membrane GO:0016021 10.24 DRD1 DRD2 DRD3 DRD4 DRD5 IMMP2L

Biological processes related to Tic Disorder according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.98 DRD4 DRD5 NRXN1 SLC18A2
2 response to drug GO:0042493 9.91 DRD1 DRD2 DRD3 SLC6A3
3 response to ethanol GO:0045471 9.88 DRD2 DRD3 SLC6A3
4 locomotory behavior GO:0007626 9.88 DRD1 DRD2 DRD3 SLC18A2 SLC6A3
5 cellular calcium ion homeostasis GO:0006874 9.87 DRD3 DRD4 DRD5
6 synapse assembly GO:0007416 9.86 DRD1 DRD2 NRXN1 SLITRK1
7 learning GO:0007612 9.83 DRD1 DRD3 NRXN1
8 social behavior GO:0035176 9.82 DRD3 DRD4 NRXN1
9 visual learning GO:0008542 9.81 DRD1 DRD2 DRD3
10 associative learning GO:0008306 9.78 DRD1 DRD2 DRD5
11 adult behavior GO:0030534 9.77 DRD2 NRXN1 SLITRK1
12 negative regulation of blood pressure GO:0045776 9.77 DRD2 DRD3 DRD5
13 arachidonic acid secretion GO:0050482 9.75 DRD2 DRD3 DRD4
14 negative regulation of protein secretion GO:0050709 9.74 DRD2 DRD3 DRD4
15 behavioral response to cocaine GO:0048148 9.73 DRD1 DRD2 DRD3 DRD4
16 behavioral fear response GO:0001662 9.72 DRD1 DRD4
17 response to morphine GO:0043278 9.72 DRD2 DRD3
18 regulation of presynapse assembly GO:1905606 9.72 NRXN1 SLITRK1
19 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.72 DRD1 NRXN1
20 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007191 9.72 DRD1 DRD3 DRD5
21 synaptic membrane adhesion GO:0099560 9.71 NRXN1 SLITRK1
22 temperature homeostasis GO:0001659 9.71 DRD1 DRD2
23 adenylate cyclase-activating adrenergic receptor signaling pathway GO:0071880 9.71 DRD2 DRD3
24 transmission of nerve impulse GO:0019226 9.71 DRD1 DRD5
25 response to iron ion GO:0010039 9.71 DRD2 SLC6A3
26 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.71 DRD2 DRD3 DRD4
27 dopamine receptor signaling pathway GO:0007212 9.71 DRD1 DRD2 DRD3 DRD4
28 long-term synaptic depression GO:0060292 9.7 DRD1 DRD5
29 striatum development GO:0021756 9.7 DRD1 DRD2
30 grooming behavior GO:0007625 9.7 DRD1 DRD2
31 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.7 DRD1 DRD2 DRD5
32 positive regulation of renal sodium excretion GO:0035815 9.69 DRD2 DRD3
33 dopamine transport GO:0015872 9.69 DRD1 SLC18A2 SLC6A3
34 G protein-coupled receptor internalization GO:0002031 9.68 DRD2 DRD3
35 regulation of postsynaptic neurotransmitter receptor internalization GO:0099149 9.68 DRD3 DRD4
36 peristalsis GO:0030432 9.68 DRD1 DRD2
37 adenohypophysis development GO:0021984 9.67 DRD2 SLC6A3
38 behavioral response to ethanol GO:0048149 9.67 DRD2 DRD4
39 monoamine transport GO:0015844 9.67 SLC18A2 SLC6A3
40 regulation of dopamine uptake involved in synaptic transmission GO:0051584 9.67 DRD1 DRD2 DRD3
41 synaptic transmission, dopaminergic GO:0001963 9.67 DRD1 DRD2 DRD3 DRD5
42 negative regulation of voltage-gated calcium channel activity GO:1901386 9.66 DRD2 DRD4
43 mating behavior GO:0007617 9.66 DRD1 DRD5
44 cellular response to catecholamine stimulus GO:0071870 9.65 DRD1 DRD5
45 cerebral cortex GABAergic interneuron migration GO:0021853 9.65 DRD1 DRD2
46 negative regulation of dopamine receptor signaling pathway GO:0060160 9.63 DRD2 DRD3
47 acid secretion GO:0046717 9.63 DRD2 DRD3
48 response to histamine GO:0034776 9.63 DRD2 DRD3 DRD4
49 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.62 DRD2 DRD4
50 regulation of locomotion involved in locomotory behavior GO:0090325 9.62 DRD2 DRD3

Molecular functions related to Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor activity GO:0004930 9.85 DRD1 DRD2 DRD3 DRD4 DRD5
2 drug binding GO:0008144 9.56 DRD2 DRD3 DRD4 SLC6A3
3 G-protein alpha-subunit binding GO:0001965 9.43 DRD1 DRD5
4 adrenergic receptor activity GO:0004935 9.4 DRD2 DRD3
5 monoamine transmembrane transporter activity GO:0008504 9.37 SLC18A2 SLC6A3
6 dopamine neurotransmitter receptor activity GO:0004952 9.35 DRD1 DRD2 DRD3 DRD4 DRD5
7 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.33 DRD2 DRD3 DRD4
8 dopamine neurotransmitter receptor activity, coupled via Gs GO:0001588 9.32 DRD1 DRD5
9 dopamine binding GO:0035240 9.1 DRD1 DRD2 DRD3 DRD4 DRD5 SLC6A3

Sources for Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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