Aliases & Classifications for Tic Disorder

MalaCards integrated aliases for Tic Disorder:

Name: Tic Disorder 12 15 73
Tics 29 6
Behavioral Tic 73

Classifications:



External Ids:

Disease Ontology 12 DOID:2769
ICD10 33 F95 F95.9
ICD9CM 35 307.2 307.20
MeSH 44 D013981
SNOMED-CT 68 35042001 568005

Summaries for Tic Disorder

Disease Ontology : 12 A specific developmental disorder that is characterized by the persistent presence of involuntary brief movements or sounds occuring intermittently and unpredictably out of a background of normal motor activity.

MalaCards based summary : Tic Disorder, also known as tics, is related to chronic tic disorder and gilles de la tourette syndrome, and has symptoms including ataxia, tremor and myoclonus. An important gene associated with Tic Disorder is DRD4 (Dopamine Receptor D4), and among its related pathways/superpathways are Circadian entrainment and Long-term potentiation. The drugs Ticagrelor and Ticlopidine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and globus pallidus, and related phenotypes are behavior/neurological and nervous system

Wikipedia : 76 Tic disorders is defined in the Diagnostic and Statistical Manual of Mental Disorders (DSM) based on... more...

Related Diseases for Tic Disorder

Diseases in the Tic Disorder family:

Chronic Tic Disorder Transient Tic Disorder

Diseases related to Tic Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 145)
# Related Disease Score Top Affiliating Genes
1 chronic tic disorder 34.1 DRD4 OFCC1
2 gilles de la tourette syndrome 32.7 DRD2 DRD4 DRD5 HDC IMMP2L SLC6A3
3 obsessive-compulsive disorder 30.3 DRD2 DRD4 HTR2A SLC6A3 SLITRK1 TPH2
4 attention deficit-hyperactivity disorder 29.9 DRD2 DRD4 DRD5 HTR2A IMMP2L SLC18A2
5 early-onset schizophrenia 29.9 DRD2 HTR2A
6 movement disease 29.8 DRD2 SLC18A2 SLC6A3
7 oppositional defiant disorder 29.8 DRD2 DRD4 SLC6A3 TPH2
8 tardive dyskinesia 29.7 DRD2 HTR2A
9 conduct disorder 29.7 DRD2 DRD4 DRD5 SLC6A3
10 autism 29.4 DRD2 DRD4 HTR2A IMMP2L SLC6A3 TDO2
11 schizophrenia 29.2 DRD2 DRD4 DRD5 HTR2A SLC18A2 SLC6A3
12 bipolar disorder 29.0 DRD2 DRD4 DRD5 HTR2A SLC18A2 SLC6A3
13 transient tic disorder 12.6
14 trigeminal neuralgia 12.1
15 pediatric autoimmune neuropsychiatric disorders associated with streptococcus infections 11.3
16 chorea, benign hereditary 11.1
17 ceroid lipofuscinosis, neuronal, 4b, autosomal dominant 11.0
18 convulsions, familial infantile, with paroxysmal choreoathetosis 11.0
19 cerebral creatine deficiency syndrome 2 11.0
20 adult neuronal ceroid lipofuscinosis 11.0
21 coasy protein-associated neurodegeneration 11.0
22 pediatric acute-onset neuropsychiatric syndrome 11.0
23 paroxysmal hemicrania 10.2
24 anxiety 10.2
25 delusional disorder 10.2 DRD2 DRD4
26 stuttering 10.2
27 myoclonus 10.2
28 hemifacial spasm 10.2
29 alcohol-induced mental disorder 10.2 DRD2 SLC6A3
30 impulse control disorder 10.1 DRD2 DRD4 SLITRK1
31 heroin dependence 10.1 DRD2 DRD4
32 substance-induced psychosis 10.1 DRD2 HTR2A
33 striatonigral degeneration 10.1 DRD2 SLC6A3
34 cocaine abuse 10.1 DRD2 SLC18A2 SLC6A3
35 trichotillomania 10.1
36 periodic limb movement disorder 10.0 DRD2 HTR2A
37 specific developmental disorder 10.0 DRD4 DRD5 SLC6A3
38 pervasive developmental disorder 10.0
39 dementia 10.0
40 primary orthostatic tremor 10.0
41 alcohol abuse 10.0 DRD2 DRD4 HTR2A
42 alcoholic psychosis 10.0 DRD2 HTR2A SLC6A3
43 adamantinoma of long bones 10.0
44 facial spasm 10.0
45 blepharospasm 10.0
46 headache 10.0
47 tobacco addiction 10.0 DRD2 HTR2A SLC6A3
48 autoimmune disease 10.0
49 autoimmune disease 1 10.0
50 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.0

Graphical network of the top 20 diseases related to Tic Disorder:



Diseases related to Tic Disorder

Symptoms & Phenotypes for Tic Disorder

UMLS symptoms related to Tic Disorder:


ataxia, tremor, myoclonus, dystonia, athetosis, symptoms, synkinesis, recurrent muscle twitches (symptom), tic, motor, tic, gestural, tic, transient, tic, vocal

MGI Mouse Phenotypes related to Tic Disorder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 DRD2 DRD4 DRD5 HDC HSPD1 HTR2A
2 nervous system MP:0003631 9.65 DRD2 DRD4 DRD5 HDC HSPD1 SLC18A2
3 taste/olfaction MP:0005394 8.92 DRD2 SLC18A2 SLC6A3 TPH2

Drugs & Therapeutics for Tic Disorder

Drugs for Tic Disorder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 371)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ticagrelor Approved Phase 4,Phase 3 274693-27-5 9871419
2
Ticlopidine Approved Phase 4,Phase 3 55142-85-3 5472
3
Clopidogrel Approved Phase 4,Phase 3 113665-84-2, 120202-66-6 60606
4
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
5
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 113775-47-6 68602 5311068
6
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
7
Clonidine Approved Phase 4 4205-90-7 2803
8
Aripiprazole Approved, Investigational Phase 4,Phase 3,Not Applicable 129722-12-9 60795
9
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Not Applicable 26787-78-0 33613
10
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-61-6, 62-31-7 681
11
Methylphenidate Approved, Investigational Phase 4,Phase 3,Not Applicable 113-45-1 4158
12
Naproxen Approved, Vet_approved Phase 4 22204-53-1 1302 156391
13 Piracetam Approved, Investigational Phase 4 7491-74-9
14
Guanfacine Approved, Investigational Phase 4,Phase 3 29110-47-2 3519
15
Riluzole Approved, Investigational Phase 4 1744-22-5 5070
16
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
17
Testosterone Approved, Investigational Phase 4 58-22-0 6013
18
Testosterone enanthate Approved Phase 4 315-37-7 9416
19
Methyltestosterone Approved Phase 4 58-18-4 6010
20
Dexlansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3, 138530-94-6 9578005
21
Domperidone Approved, Investigational, Vet_approved Phase 4 57808-66-9 3151
22
Lansoprazole Approved, Investigational Phase 4,Phase 3 103577-45-3 3883
23
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
24
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
25
Fluvoxamine Approved, Investigational Phase 4 54739-18-3 3404 5324346
26
Haloperidol Approved Phase 4,Phase 3 52-86-8 3559
27
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
28
Amlodipine Approved Phase 4 88150-42-9 2162
29
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
30
Budesonide Approved Phase 4 51333-22-3 63006 5281004
31
Codeine Approved, Illicit Phase 4 76-57-3 5284371
32
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
33
Benzocaine Approved, Investigational Phase 4,Not Applicable 94-09-7, 1994-09-7 2337
34
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
35
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 437-38-7 3345
36
Sufentanil Approved, Investigational Phase 4,Phase 3,Not Applicable 56030-54-7 41693
37
Nitrous oxide Approved, Vet_approved Phase 4,Not Applicable 10024-97-2 948
38 tannic acid Approved Phase 4,Not Applicable
39
Cycloserine Approved Phase 4,Not Applicable 68-41-7 6234 401
40
Flurbiprofen Approved, Investigational Phase 4,Phase 1 5104-49-4 3394
41
Midazolam Approved, Illicit Phase 4,Phase 3,Not Applicable 59467-70-8 4192
42
Acetylcysteine Approved, Investigational Phase 4,Phase 2 616-91-1 12035
43
Ondansetron Approved Phase 4 99614-02-5 4595
44
Cefdinir Approved Phase 4 91832-40-5 6915944
45
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
46
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
47
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4 1177-87-3
48
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
49
Morphine Approved, Investigational Phase 4,Not Applicable 57-27-2 5288826
50
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 175805 71273

Interventional clinical trials:

(show top 50) (show all 390)
# Name Status NCT ID Phase Drugs
1 Comparison of TIcagrelor and Clopidogrel in Patients With Coronary Artery diseaSe and Type 2 Diabetes Mellitus (TICS-DM) Unknown status NCT02457130 Phase 4 Ticagrelor;Clopidogrel
2 Long Term Postoperative Cognitive Dysfunction in the Elderly Patients Unknown status NCT02301676 Phase 4 Sevoflurane;propofol
3 Study of Clonidine on Sleep Architecture in Children With Tourette's Syndrome (TS) and Comorbid ADHD Unknown status NCT00152750 Phase 4 APO-clonidine
4 Comparison of Keppra and Clonidine in the Treatment of Tics Completed NCT00370838 Phase 4 Levetiracetam;Clonidine
5 Guanfacine in Children With Tic Disorders Completed NCT01547000 Phase 4 placebo;extended-release guanfacine (Intuniv)
6 Open Label Trial of Aripiprazole in Children and Adolescents With Tourette's Disorder Completed NCT00241176 Phase 4 Aripiprazole
7 Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission Completed NCT01018056 Phase 4 D-serine;Riluzole;Placebo
8 Benefit of the Treatment With Testosterone in Chronic Heart Failure Testosterone Deficiency Subjects Completed NCT01813201 Phase 4 Testosterone undecanoate;Saline isotonic solution
9 Amoxicillin for the Treatment of Pediatric Autoimmune Disorders Associated With Streptococcal Infections Completed NCT00001658 Phase 4 Amoxicillin
10 Surface Acoustic Wave Ultrasound in Trigeminal Neuralgia Pain Completed NCT01447108 Phase 4
11 Comparison of 24 Hour Bronchodilator Efficacy of Tiotropium 18 mcg Delivered Via DISCAIR Versus SPIRIVA 18 µg Delivered Via HANDIHALER® in Patients With Moderate to Severe COPD Completed NCT02541006 Phase 4 Tiotropium 18 mcg
12 The Efficacy of Lansoprazole and Domperidone Combination on Intragastric and Intraesophageal Acidity Completed NCT02958046 Phase 4 Lansoprazole/Domperidone
13 Impact of Dexmedetomidine on the Post-Operative Cognition Dysfunction(POCD) in Geriatric Patients Completed NCT02275182 Phase 4 Dexmedetomidine;Saline
14 Controlled Hypotension During Functional Endoscopic Sinus Surgery Completed NCT01956981 Phase 4 Magnesium Sulfate;Dexmedetomidine
15 Olanzapine in the Treatment of Hair Pulling (Trichotillomania) Completed NCT00182507 Phase 4 Olanzapine
16 Treatment of Obsessive-Compulsive Disorder Completed NCT00000373 Phase 4 olanzapine + fluoxetine;placebo + fluoxetine
17 Efficacy and Safety of S-amlodipine 2,5 mg and 5 mg in Hypertension Patients Completed NCT03038451 Phase 4 S-NOR (s-amlodipine) 2,5 mg & 5 mg tablet
18 Comparison of the Effect of Rabeprazole 50 mg DDR Capsules and 20 mg Enteric-coated Tablets Completed NCT03037606 Phase 4 Rabelis DDR 50 mg Capsules;Pariet 20 mg Enteric Coated Tablets
19 Assessment of Bronchodilator Efficacy of Formoterol/Budesonide 12/400 mcg Via Discair in COPD Completed NCT03028701 Phase 4 Formoterol/Budesonide 12/400 mcg Discair
20 Tiotropium/Formoterol Via Discair® vs Tiotropium Monotherapy or Tiotropium + Formoterol Free Combination Treatment Completed NCT02988869 Phase 4 Tiotropium/Formoterol;Tiotropium;Formoterol;Tiotropium
21 The Efficacy and Safety of Dapoxetine/Sildenafil Combination Therapy Completed NCT02939495 Phase 4 Dapoxetine/Sildenafil 30/50 mg film coated tablet
22 The Effect of Dexrabeprazole on Intragastric and Intraesophageal Acidity Completed NCT02689999 Phase 4 Dexrabeprazole 10 mg Enteric-Coated Tablets
23 Efficacy and Safety of Imuneks 10 mg Capsules in the Prophylaxis of Cold Completed NCT02807220 Phase 4 Imuneks 10mg
24 Stimulant Versus Nonstimulant Medication for Attention Deficit Hyperactivity Disorder in Children Completed NCT00183391 Phase 4 Atomoxetine;Methylphenidate
25 Dexmedetomidine and Delirium in Patients After Cardiac Surgery Completed NCT02267538 Phase 4 dexmedetomidine hydrochloride for injection;0.9% sodium chloride for injection
26 Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis Completed NCT02501564 Phase 4 Naproxen Sodium Codeine;Placebo
27 Dexmedetomidine and Long-term Outcome in Elderly Patients After Surgery Completed NCT02809937 Phase 4 dexmedetomidine;placebo
28 Impact of Anesthesia Maintenance Methods on Incidence of Postoperative Delirium Completed NCT02662257 Phase 4 Sevoflurane;Propofol
29 Dexmedetomidine and Long-term Outcomes in Elderly Patients After Cardiac Surgery Completed NCT03289325 Phase 4 dexmedetomidine hydrochloride for injection;0.9% sodium chloride for injection
30 Lisdexamfetamine Dimesylate in the Treatment of Adult ADHD With Anxiety Disorder Comorbidity Completed NCT01863459 Phase 4 Lisdexamfetamine Dimesylate;placebo
31 D-Cycloserine as an Adjunct to Internet-CBT for OCD Completed NCT01649895 Phase 4 D-Cycloserine;Placebo
32 Effects of Ondansetron in Obsessive-compulsive and Tic Disorders Recruiting NCT03239210 Phase 4 Ondansetron;Placebo
33 Trial to Evaluate the Long-term Efficacy of Oral Aripiprazole in the Treatment of Pediatric Subjects With Tourette's Disorder Recruiting NCT03661983 Phase 4 Aripiprazole (OPC-14597);Placebo
34 Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Adults Recruiting NCT03400735 Phase 4 Cefdinir 300Mg Capsule
35 Tiotropium/Salmeterol/Fluticasone Fixed Dose Combination Tratment Via Discair vs Tiotropium Via Handihaler + Salmeterol/Fluticasone Via Diskus Free Combination Treatment Recruiting NCT03395002 Phase 4 Tiotropium/Salmeterol/Fluticasone 9/50/500 mcg Inhalation Powder;Tiotropium 18 mcg Inhalation Powder;Salmeterol/Fluticasone 50/500 mcg Inhalation Powder
36 The Safety of Dapoxetine/Tadalafil Combination Therapy Recruiting NCT03177746 Phase 4 Dapoxetine/Tadalafil 30/20 mg film coated tablet
37 Dexamethasone, Flurbiprofen Axetil and Long-term Survival After Lung Cancer Surgery Recruiting NCT03172988 Phase 4 Dexamethasone;Normal saline;Flurbiprofen axetil;Lipid microsphere
38 Dexmedetomidine Supplemented Analgesia and 2-Year Survival After Cancer Surgery Recruiting NCT03012971 Phase 4 Dexmedetomidine supplemented morphine analgesia;Morphine analgesia
39 Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery Recruiting NCT03629262 Phase 4 Dexmedetomidine;Placebo
40 Dexmedetomidine Combined With Ropivacaine for Postoperative Continuous Femoral Nerve Block Recruiting NCT03629483 Phase 4 Dexmedetomidine;Placebo
41 Dexmedetomidine Supplemented Analgesia and Incidence of Postoperative Delirium Recruiting NCT03012984 Phase 4 Dexmedetomidine supplemented morphine analgesia;Morphine analgesia
42 Dexamethasone, Flurbiprofen Axetil and Delirium After Lung Cancer Surgery Recruiting NCT03200600 Phase 4 Dexamethasone;Normal saline;Flurbiprofen axetil;Lipid microsphere
43 Low-dose Dexmedetomidine in Mechanically Ventilated ICU Patients Recruiting NCT03172897 Phase 4 Dexmedetomidine;Placebo (normal saline)
44 Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients Recruiting NCT03335527 Phase 4 Dexmedetomidine;Placebo (normal saline)
45 A Study to Evaluate the Benefit of Octagam 5%® in Subjects With Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) Active, not recruiting NCT03348618 Phase 4
46 Impact of Anesthesia Maintenance Methods on Long-term Survival Rate Active, not recruiting NCT02660411 Phase 4 Sevoflurane;Propofol
47 Efficacy and Safety Study of Acetylcysteine/Doxofylline 1200/400 mg Effervescent Tablet in the Treatment of Moderate-Severe COPD. Not yet recruiting NCT03388853 Phase 4 Acetylcysteine/Doxofylline
48 Salmeterol/Fluticasone 50/500 mcg Inhalation Powder Via Capsair vs Seretide Diskus 500 mcg Inhalation Powder in Patients With COPD Not yet recruiting NCT03363503 Phase 4 Salmeterol/Fluticasone Capsair®;Salmeterol/Fluticasone Diskus®
49 Cardiac Safety of Lansoprazole and Domperidon Combination Not yet recruiting NCT03355170 Phase 4 Lansoprazole
50 Low-dose Dexmedetomidine and Postoperative Delirium After Cardiac Surgery Not yet recruiting NCT03624595 Phase 4 Dexmedetomidine;Placebo

Search NIH Clinical Center for Tic Disorder

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Tic Disorder

Genetic tests related to Tic Disorder:

# Genetic test Affiliating Genes
1 Tics 29

Anatomical Context for Tic Disorder

MalaCards organs/tissues related to Tic Disorder:

41
Brain, Testes, Globus Pallidus, Thyroid, B Cells, Eye, T Cells

Publications for Tic Disorder

Articles related to Tic Disorder:

(show top 50) (show all 674)
# Title Authors Year
1
A Randomized Controlled Trial Comparing Behavioral, Educational, and Pharmacological Treatments in Youths With Chronic Tic Disorder or Tourette Syndrome. ( 29636706 )
2018
2
Seroprevalance Anti-Toxoplasma gondii antibodies in children and adolescents with tourette syndrome/chronic motor or vocal tic disorder: A case-control study. ( 29554545 )
2018
3
Phenomenology and Clinical Correlates of Stimulus-Bound Tics in Gilles de la Tourette Syndrome. ( 29988443 )
2018
4
Distinctive tics suppression network in Gilles de la Tourette syndrome distinguished from suppression of natural urges using multimodal imaging. ( 30268027 )
2018
5
Bupropion-Related Exacerbation of Tic Disorder in an Adult: A Case Report. ( 30499776 )
2018
6
An exploratory study into an adapted use of the Alert Program for tic disorder in children. ( 30501513 )
2018
7
Tics and Tourette syndrome - surplus of actions rather than disorder? ( 29278288 )
2018
8
Tourette syndrome in a longitudinal perspective. Clinical course of tics and comorbidities, coexisting psychopathologies, phenotypes and predictors. ( 29619935 )
2018
9
Tics and Tourette syndrome. ( 30294996 )
2018
10
Subjective embodiment during the rubber hand illusion predicts severity of premonitory sensations and tics in Tourette Syndrome. ( 30337222 )
2018
11
Polygenic Risk Scores Derived From a Tourette Syndrome Genome-wide Association Study Predict Presence of Tics in the Avon Longitudinal Study of Parents and Children Cohort. ( 30424865 )
2018
12
NFκB-Mediated Invasiveness in CD133+ Pancreatic TICs Is Regulated by Autocrine and Paracrine Activation of IL1 Signaling. ( 28970361 )
2018
13
Premonitory Urge for Tics Scale (PUTS): replication and extension of psychometric properties in youth with chronic tic disorders (CTDs). ( 29185077 )
2018
14
Botulinum toxin for motor and phonic tics in Tourette's syndrome. ( 29304272 )
2018
15
Factor structure and psychometric properties of the english version of the trier inventory for chronic stress (TICS-E). ( 29409461 )
2018
16
Aripiprazole Selectively Reduces Motor Tics in a Young Animal Model for Tourette's Syndrome and Comorbid Attention Deficit and Hyperactivity Disorder. ( 29487562 )
2018
17
Update on the Pharmacological Treatment of Tics with Dopamine-Modulating Agents. ( 29498507 )
2018
18
Evaluation and Adaption of the Trier Inventory for Chronic Stress (TICS) for Assessment in Competitive Sports. ( 29593611 )
2018
19
Inhibition is impaired in children with obsessive-compulsive symptoms but not in those with tics. ( 29781133 )
2018
20
Pharmacotherapies to tics: a systematic review. ( 29963275 )
2018
21
European Multicentre Tics in Children Studies (EMTICS): protocol for two cohort studies to assess risk factors for tic onset and exacerbation in children and adolescents. ( 29982875 )
2018
22
Quick Flicks: Association of Paroxysmal Kinesigenic Dyskinesia and Tics. ( 29984260 )
2018
23
A Review on Functional Analyses of Tics. ( 30373380 )
2018
24
circCTIC1 promotes the self-renewal of colon TICs through BPTF-dependent c-Myc expression. ( 30403769 )
2018
25
LncHOXA10 drives liver TICs self-renewal and tumorigenesis via HOXA10 transcription activation. ( 30545354 )
2018
26
Adult-onset pure tic disorder after post-traumatic hypoxic lesions of the globus pallidus. ( 27887894 )
2017
27
Parental age and the risk of obsessive compulsive disorder and Tourette syndrome / chronic tic disorder in a nationwide population-based sample. ( 28738196 )
2017
28
Revisiting the co-existence of Attention-Deficit/Hyperactivity Disorder and Chronic Tic Disorder in childhood-The case of colour discrimination, sustained attention and interference control. ( 28594866 )
2017
29
Very Early-onset Schizophrenia with Secondary Onset Tic Disorder. ( 28852253 )
2017
30
Parental Psychopathology and Tourette Syndrome/Chronic Tic Disorder in Offspring: A Nationwide Case-Control Study. ( 28335873 )
2017
31
Chronic recurrent dislocation of the temporomandibular joint secondary to a complex facial tic disorder. ( 29017736 )
2017
32
The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. ( 28894297 )
2017
33
Pediatric Tourette Syndrome: A Tic Disorder with a Tricky Presentation. ( 28611559 )
2017
34
Parsing the phenotype of obsessive-compulsive tic disorder (OCTD): a multidisciplinary consensus. ( 28379724 )
2017
35
Toward a Multifactorial Conception of the Gilles de la Tourette Syndrome and Persistent Chronic Tic Disorder. ( 28574423 )
2017
36
Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients. ( 28796166 )
2017
37
Atomoxetine Use in Attention-Deficit/Hyperactivity Disorder and Comorbid Tic Disorder in Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections. ( 27315236 )
2017
38
Deep Brain Stimulation of the H Fields of Forel Alleviates Tics in Tourette Syndrome. ( 28659777 )
2017
39
Premonitory urges and tics in Tourette syndrome: computational mechanisms and neural correlates. ( 29017141 )
2017
40
A marked point process approach for identifying neural correlates of tics in Tourette Syndrome. ( 29060866 )
2017
41
Fear of fear, severe tics and deep brain stimulation in childhood Tourette Syndrome: The long and winding road. ( 28012699 )
2017
42
Moderators and predictors of response to behavior therapy for tics in Tourette syndrome. ( 28202705 )
2017
43
Persistent Tics, Tourette Syndrome, and Psychopathology: Where Are We Now, and Where Are We Going? ( 28335870 )
2017
44
Dysfunctions of the basal ganglia-cerebellar-thalamo-cortical system produce motor tics in Tourette syndrome. ( 28358814 )
2017
45
Tics and Tourette Syndrome. ( 28418483 )
2017
46
Tics as an initial manifestation of juvenile Huntington's disease: case report and literature review. ( 28789621 )
2017
47
Serum Ferritin Levels Are Lower in Children With Tic Disorders Compared with Children Without Tics: A Cross-Sectional Study. ( 27548271 )
2017
48
Systematic review of severity scales and screening instruments for tics: Critique and recommendations. ( 28071825 )
2017
49
Modeling tics in rodents: Conceptual challenges and paths forward. ( 28237575 )
2017
50
Increased Risk of Tics in Children Infected with Enterovirus: A Nationwide Population-Based Study. ( 28353494 )
2017

Variations for Tic Disorder

Expression for Tic Disorder

Search GEO for disease gene expression data for Tic Disorder.

Pathways for Tic Disorder

Pathways related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 DRD2 DRD4 DRD5 SLC18A2 SLC6A3
2
Show member pathways
11.87 DRD2 DRD4 DRD5
3 11.85 HSPD1 HTR2A TPH2
4
Show member pathways
11.61 DRD2 SLC18A2 SLC6A3
5 11.56 HTR2A SLC18A2 TPH2
6
Show member pathways
11.44 DRD2 DRD4 SLC18A2
7
Show member pathways
10.98 DRD2 DRD4 DRD5 HTR2A
8 10.97 SLC18A2 SLC6A3
9
Show member pathways
10.97 SLC6A3 TDO2 TPH2
10 10.78 DRD2 DRD5
11 10.58 HTR2A SLC18A2 TPH2

GO Terms for Tic Disorder

Cellular components related to Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 DRD2 DRD4 DRD5 HTR2A SLC18A2 SLC6A3
2 glutamatergic synapse GO:0098978 9.56 DRD2 DRD4 HTR2A SLITRK1
3 non-motile cilium GO:0097730 9.37 DRD2 DRD5
4 integral component of presynaptic membrane GO:0099056 9.33 DRD2 HTR2A SLC6A3
5 integral component of postsynaptic membrane GO:0099055 9.13 DRD2 HTR2A SLC6A3
6 dopaminergic synapse GO:0098691 8.8 DRD2 SLC18A2 SLC6A3

Biological processes related to Tic Disorder according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.88 DRD2 HSPD1 HTR2A SLC6A3
2 chemical synaptic transmission GO:0007268 9.83 DRD4 DRD5 HTR2A SLC18A2
3 cellular calcium ion homeostasis GO:0006874 9.75 DRD4 DRD5 HTR2A
4 locomotory behavior GO:0007626 9.73 DRD2 SLC18A2 SLC6A3
5 G protein-coupled serotonin receptor signaling pathway GO:0098664 9.65 DRD4 HTR2A
6 associative learning GO:0008306 9.65 DRD2 DRD5
7 adult behavior GO:0030534 9.65 DRD2 SLITRK1
8 negative regulation of blood pressure GO:0045776 9.64 DRD2 DRD5
9 arachidonic acid secretion GO:0050482 9.64 DRD2 DRD4
10 temperature homeostasis GO:0001659 9.63 DRD2 HTR2A
11 positive regulation of kinase activity GO:0033674 9.63 DRD4 HTR2A
12 dopamine receptor signaling pathway GO:0007212 9.62 DRD2 DRD4
13 negative regulation of protein secretion GO:0050709 9.62 DRD2 DRD4
14 response to iron ion GO:0010039 9.61 DRD2 SLC6A3
15 synaptic transmission, dopaminergic GO:0001963 9.61 DRD2 DRD5
16 dopamine metabolic process GO:0042417 9.6 DRD2 DRD4
17 prepulse inhibition GO:0060134 9.59 DRD2 SLC6A3
18 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.57 HSPD1 SLC18A2
19 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007195 9.55 DRD2 DRD4
20 regulation of dopamine metabolic process GO:0042053 9.54 DRD4 SLC6A3
21 adenohypophysis development GO:0021984 9.51 DRD2 SLC6A3
22 behavioral response to ethanol GO:0048149 9.49 DRD2 DRD4
23 monoamine transport GO:0015844 9.48 SLC18A2 SLC6A3
24 negative regulation of synaptic transmission, glutamatergic GO:0051967 9.46 DRD2 HTR2A
25 negative regulation of voltage-gated calcium channel activity GO:1901386 9.43 DRD2 DRD4
26 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.4 DRD2 DRD5
27 dopamine transport GO:0015872 9.37 SLC18A2 SLC6A3
28 behavioral response to cocaine GO:0048148 9.33 DRD2 DRD4 HTR2A
29 positive regulation of dopamine uptake involved in synaptic transmission GO:0051586 9.32 DRD2 DRD4
30 response to histamine GO:0034776 9.26 DRD2 DRD4
31 response to cocaine GO:0042220 9.26 DRD2 DRD5 HSPD1 SLC6A3
32 response to amphetamine GO:0001975 8.92 DRD2 DRD4 DRD5 SLC18A2

Molecular functions related to Tic Disorder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 drug binding GO:0008144 9.46 DRD2 DRD4 HTR2A SLC6A3
2 G-protein alpha-subunit binding GO:0001965 9.37 DRD5 HTR2A
3 dopamine neurotransmitter receptor activity, coupled via Gi/Go GO:0001591 9.32 DRD2 DRD4
4 monoamine transmembrane transporter activity GO:0008504 9.26 SLC18A2 SLC6A3
5 dopamine neurotransmitter receptor activity GO:0004952 9.13 DRD2 DRD4 DRD5
6 dopamine binding GO:0035240 8.92 DRD2 DRD4 DRD5 SLC6A3

Sources for Tic Disorder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....