MCID: TCK003
MIFTS: 28

Tick-Borne Relapsing Fever

Categories: Infectious diseases

Aliases & Classifications for Tick-Borne Relapsing Fever

MalaCards integrated aliases for Tick-Borne Relapsing Fever:

Name: Tick-Borne Relapsing Fever 12 3 15 74
Relapsing Fever, Tick-Borne 12 3

Classifications:



External Ids:

Disease Ontology 12 DOID:13036
ICD9CM 36 087.1
NCIt 51 C34976
SNOMED-CT 69 10301003
ICD10 34 A68.1
UMLS 74 C0035022

Summaries for Tick-Borne Relapsing Fever

Disease Ontology : 12 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Tick-Borne Relapsing Fever, also known as relapsing fever, tick-borne, is related to relapsing fever and tick infestation, and has symptoms including lymphadenopathy, tachycardia and tachypnea. An important gene associated with Tick-Borne Relapsing Fever is CLPX (Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit). The drugs Doxycycline and Anti-Infective Agents have been mentioned in the context of this disorder. Related phenotypes are Decreased viability and Decreased viability

CDC : 3 Tick-borne Relapsing Fever

Related Diseases for Tick-Borne Relapsing Fever

Diseases related to Tick-Borne Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 relapsing fever 11.6
2 tick infestation 11.4
3 malaria 10.3
4 glanders 10.1
5 plasmodium falciparum malaria 10.1
6 severe acute respiratory syndrome 10.1
7 radiculopathy 10.1
8 myocarditis 10.1
9 acute respiratory distress syndrome 10.1
10 headache 10.1

Graphical network of the top 20 diseases related to Tick-Borne Relapsing Fever:



Diseases related to Tick-Borne Relapsing Fever

Symptoms & Phenotypes for Tick-Borne Relapsing Fever

Symptoms:

12
  • lymphadenopathy
  • tachycardia
  • tachypnea
  • hepatosplenomegaly

GenomeRNAi Phenotypes related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-2 9.32 AKAP13 EPHA5
2 Decreased viability GR00221-A-3 9.32 AKAP13 EPHA5
3 Decreased viability GR00221-A-4 9.32 EPHA5
4 Decreased viability GR00342-S-1 9.32 AKAP13
5 Decreased viability GR00342-S-3 9.32 AKAP13 EPHA5
6 Decreased viability GR00402-S-2 9.32 AKAP13 EPHA5

Drugs & Therapeutics for Tick-Borne Relapsing Fever

Drugs for Tick-Borne Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
2 Anti-Infective Agents Phase 2, Phase 3
3 Antiprotozoal Agents Phase 2, Phase 3
4 Antiparasitic Agents Phase 2, Phase 3
5 Anti-Bacterial Agents Phase 2, Phase 3
6 Antimalarials Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment

Search NIH Clinical Center for Tick-Borne Relapsing Fever

Genetic Tests for Tick-Borne Relapsing Fever

Anatomical Context for Tick-Borne Relapsing Fever

Publications for Tick-Borne Relapsing Fever

Articles related to Tick-Borne Relapsing Fever:

(show top 50) (show all 121)
# Title Authors Year
1
Erratum for Krishnavajhala et al., "Vector Competence of Geographical Populations of Ornithodoros turicata for the Tick-Borne Relapsing Fever Spirochete Borrelia turicatae". ( 30787072 )
2019
2
Tick-Borne Relapsing Fever in the White Mountains, Arizona, USA, 2013-2018. ( 30882304 )
2019
3
Case report: A retrospective serological analysis indicating human exposure to tick-borne relapsing fever spirochetes in Sonora, Mexico. ( 30973877 )
2019
4
Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29658212 )
2018
5
Tick-borne relapsing fever as a potential veterinary medical problem. ( 29943903 )
2018
6
Novel real-time PCR assays for genomic group identification of tick-borne relapsing fever species Borrelia hermsii. ( 30131238 )
2018
7
Vector competence of geographical populations of Ornithodoros turicata for the tick-borne relapsing fever spirochete Borrelia turicatae. ( 30143510 )
2018
8
Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. ( 30372445 )
2018
9
Plasmodium falciparum malaria co-infection with tick-borne relapsing fever in Dakar. ( 28077149 )
2017
10
Tick-Borne Relapsing Fever in Southwest Colorado: A Case Report. ( 27650717 )
2017
11
Development and optimization of an in vitro cultivation protocol allows for isolation of Borrelia miyamotoi from patients with hard tick-borne relapsing fever. ( 28110053 )
2017
12
Ecological niche modeling and distribution of Ornithodoros hermsi associated with tick-borne relapsing fever in western North America. ( 29084219 )
2017
13
Serological detection of Tick-Borne Relapsing Fever in Texan domestic dogs. ( 29232415 )
2017
14
Borrelia miyamotoi: A human tick-borne relapsing fever spirochete in Europe and its potential impact on public health. ( 27100337 )
2016
15
Chromosome and Plasmids of the Tick-Borne Relapsing Fever Agent Borrelia hermsii. ( 27284141 )
2016
16
Tick-Borne Relapsing Fever in Dogs. ( 27353196 )
2016
17
Chromosome and Linear Plasmid Sequences of a 2015 Human Isolate of the Tick-Borne Relapsing Fever Spirochete, Borrelia turicatae. ( 27417836 )
2016
18
Tick-Borne Relapsing Fever Outbreak Among a High School Football Team at an Outdoor Education Camping Trip, Arizona, 2014. ( 27430539 )
2016
19
An Alternative Strategy of Preventive Control of Tick-Borne Relapsing Fever in Rural Areas of Sine-Saloum, Senegal. ( 27430543 )
2016
20
Tick-Borne Relapsing Fever, Southern Spain, 2004-2015. ( 27442975 )
2016
21
Host associations and genomic diversity of Borrelia hermsii in an endemic focus of tick-borne relapsing fever in western North America. ( 27832805 )
2016
22
Tick-Borne Relapsing Fever Spirochetes in the Americas. ( 28959690 )
2016
23
Regarding Tick-Borne Relapsing Fever in the Americas; Some Historical Aspects of a Forgotten Disease in Colombia. ( 29056741 )
2016
24
Blood transfusion transmission of the tick-borne relapsing fever spirochete Borrelia miyamotoi in mice. ( 25251880 )
2015
25
Case report: A retrospective serological analysis indicating human exposure to tick-borne relapsing fever spirochetes in Texas. ( 25856342 )
2015
26
Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete. ( 25892254 )
2015
27
Tick-borne Relapsing Fever in Children in the North-west of Iran, Qazvin. ( 26445390 )
2015
28
Tick-borne relapsing fever in pregnancy. ( 23939208 )
2014
29
Postexposure prophylaxis of tick-borne relapsing fever: lessons learned from recent outbreaks in Israel. ( 24107216 )
2013
30
Tick-borne relapsing fever with cutaneous eschar and radiculopathy, Ethiopia. ( 22776391 )
2012
31
Endemic foci of the tick-borne relapsing fever spirochete Borrelia crocidurae in Mali, West Africa, and the potential for human infection. ( 23209863 )
2012
32
A 20-year-old man with fever, headache, and neck stiffness. Neuroborreliosis with tick-borne relapsing fever. ( 21288847 )
2011
33
Tick-borne relapsing fever borreliosis, rural senegal. ( 21529402 )
2011
34
Elevated troponin and jarisch-herxheimer reaction in tick-borne relapsing Fever: a case report. ( 22567483 )
2011
35
Post exposure prophylaxis of tick-borne relapsing fever. ( 20012878 )
2010
36
Molecular characterization of Borrelia persica, the agent of tick borne relapsing fever in Israel and the Palestinian Authority. ( 21124792 )
2010
37
The epidemiology of tick-borne relapsing fever in Iran during 1997-2006. ( 19411042 )
2009
38
Tick-borne relapsing fever and Borrelia hermsii, Los Angeles County, California, USA. ( 19624916 )
2009
39
Tick-borne relapsing fever in a new highland endemic focus of western Iran. ( 19695158 )
2009
40
Congenital tick-borne relapsing fever: report of a case with transplacental transmission in the Islamic Republic of Iran. ( 19731794 )
2009
41
Tick-borne relapsing fever: conjunctival haemorrhages. ( 21686925 )
2009
42
Tick talk: unusually severe case of tick-borne relapsing fever with acute respiratory distress syndrome--case report and review of the literature. ( 19099321 )
2008
43
Absence of transovarial transmission of Borrelia duttonii, a tick-borne relapsing fever agent, by the vector tick Ornithodoros moubata. ( 18454593 )
2008
44
Tick-borne relapsing fever. ( 18755384 )
2008
45
Community knowledge, attitudes and practices related to tick-borne relapsing fever in dodoma rural district, central Tanzania. ( 19024337 )
2008
46
Tick-borne relapsing fever polymerase chain reaction of tick-borne relapsing fever caused by Borrelia hermsii. ( 17484230 )
2007
47
Does tick-borne relapsing fever have an animal reservoir in East Africa? ( 18021022 )
2007
48
Killed in action: microbiologists and clinicians as victims of their occupation. Part 4: Tick-borne Relapsing Fever, Malta Fever, Glanders, SARS. ( 16423683 )
2006
49
Immunological and molecular analyses of the Borrelia hermsii factor H and factor H-like protein 1 binding protein, FhbA: demonstration of its utility as a diagnostic marker and epidemiological tool for tick-borne relapsing fever. ( 16861638 )
2006
50
Doxycycline for the prevention of tick-borne relapsing fever. ( 17035657 )
2006

Variations for Tick-Borne Relapsing Fever

Expression for Tick-Borne Relapsing Fever

Search GEO for disease gene expression data for Tick-Borne Relapsing Fever.

Pathways for Tick-Borne Relapsing Fever

GO Terms for Tick-Borne Relapsing Fever

Cellular components related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 8.8 AKAP13 EPHA5 MAP6

Sources for Tick-Borne Relapsing Fever

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
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50 NCI
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59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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