MCID: TCK003
MIFTS: 29

Tick-Borne Relapsing Fever

Categories: Infectious diseases

Aliases & Classifications for Tick-Borne Relapsing Fever

MalaCards integrated aliases for Tick-Borne Relapsing Fever:

Name: Tick-Borne Relapsing Fever 12 3 15 73
Relapsing Fever, Tick-Borne 12 3

Classifications:



External Ids:

Disease Ontology 12 DOID:13036
ICD10 33 A68.1
ICD9CM 35 087.1
NCIt 50 C34976
SNOMED-CT 68 10301003
UMLS 73 C0035022

Summaries for Tick-Borne Relapsing Fever

Disease Ontology : 12 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has_material basis_in Borrelia hermsii, has_material basis_in Borrelia parkeri or has_material basis_in Borrelia duttoni, which are transmitted by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

MalaCards based summary : Tick-Borne Relapsing Fever, also known as relapsing fever, tick-borne, is related to relapsing fever and tick infestation, and has symptoms including lymphadenopathy, tachycardia and tachypnea. An important gene associated with Tick-Borne Relapsing Fever is CLPX (Caseinolytic Mitochondrial Matrix Peptidase Chaperone Subunit). The drugs Doxycycline and Antiparasitic Agents have been mentioned in the context of this disorder. Related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

CDC : 3 Tick-borne Relapsing Fever

Related Diseases for Tick-Borne Relapsing Fever

Diseases related to Tick-Borne Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 relapsing fever 32.1 CLPX PURA
2 tick infestation 11.4
3 malaria 10.3
4 glanders 10.1
5 plasmodium falciparum malaria 10.1
6 radiculopathy 10.1
7 myocarditis 10.1
8 acute respiratory distress syndrome 10.1
9 headache 10.1

Graphical network of the top 20 diseases related to Tick-Borne Relapsing Fever:



Diseases related to Tick-Borne Relapsing Fever

Symptoms & Phenotypes for Tick-Borne Relapsing Fever

Symptoms:

12
  • lymphadenopathy
  • tachycardia
  • tachypnea
  • hepatosplenomegaly

GenomeRNAi Phenotypes related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-129 9.44 GEN1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-146 9.44 PURA
3 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.44 PURA
4 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.44 PURA
5 Increased shRNA abundance (Z-score > 2) GR00366-A-23 9.44 PURA
6 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.44 PURA
7 Increased shRNA abundance (Z-score > 2) GR00366-A-4 9.44 GEN1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-41 9.44 GEN1 PURA
9 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.44 GEN1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-46 9.44 GEN1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.44 PURA
12 Increased shRNA abundance (Z-score > 2) GR00366-A-81 9.44 PURA

Drugs & Therapeutics for Tick-Borne Relapsing Fever

Drugs for Tick-Borne Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
2 Antiparasitic Agents Phase 2, Phase 3
3 Antiprotozoal Agents Phase 2, Phase 3
4 Antimalarials Phase 2, Phase 3
5 Anti-Infective Agents Phase 2, Phase 3
6 Anti-Bacterial Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment

Search NIH Clinical Center for Tick-Borne Relapsing Fever

Genetic Tests for Tick-Borne Relapsing Fever

Anatomical Context for Tick-Borne Relapsing Fever

Publications for Tick-Borne Relapsing Fever

Articles related to Tick-Borne Relapsing Fever:

(show top 50) (show all 119)
# Title Authors Year
1
Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29658212 )
2018
2
Tick-Borne Relapsing Fever with Severe Jarisch-Herxheimer Reaction. ( 29333799 )
2018
3
Tick-borne relapsing fever as a potential veterinary medical problem. ( 29943903 )
2018
4
Novel real-time PCR assays for genomic group identification of tick-borne relapsing fever species Borrelia hermsii. ( 30131238 )
2018
5
Vector competence of geographical populations of Ornithodoros turicata for the tick-borne relapsing fever spirochete Borrelia turicatae. ( 30143510 )
2018
6
Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. ( 30372445 )
2018
7
Ecological niche modeling and distribution of Ornithodoros hermsi associated with tick-borne relapsing fever in western North America. ( 29084219 )
2017
8
Serological detection of Tick-Borne Relapsing Fever in Texan domestic dogs. ( 29232415 )
2017
9
Development and optimization of an inA vitro cultivation protocol allows for isolation of Borrelia miyamotoi from patients with hard tick-borne relapsing fever. ( 28110053 )
2017
10
Plasmodium falciparum malaria co-infection with tick-borne relapsing fever in Dakar. ( 28077149 )
2017
11
Regarding Tick-Borne Relapsing Fever in the Americas; Some Historical Aspects of a Forgotten Disease in Colombia. ( 29056741 )
2016
12
Tick-Borne Relapsing Fever in Dogs. ( 27353196 )
2016
13
Tick-Borne Relapsing Fever, Southern Spain, 2004-2015. ( 27442975 )
2016
14
Tick-Borne Relapsing Fever Spirochetes in the Americas. ( 28959690 )
2016
15
An Alternative Strategy of Preventive Control of Tick-Borne Relapsing Fever in Rural Areas of Sine-Saloum, Senegal. ( 27430543 )
2016
16
Tick-Borne Relapsing Fever Outbreak Among a High School Football Team at an Outdoor Education Camping Trip, Arizona, 2014. ( 27430539 )
2016
17
Borrelia miyamotoi: A human tick-borne relapsing fever spirochete in Europe and its potential impact on public health. ( 27100337 )
2016
18
Tick-Borne Relapsing Fever in Southwest Colorado: A Case Report. ( 27650717 )
2016
19
Host associations and genomic diversity of Borrelia hermsii in an endemic focus of tick-borne relapsing fever in western North America. ( 27832805 )
2016
20
Chromosome and Plasmids of the Tick-Borne Relapsing Fever Agent Borrelia hermsii. ( 27284141 )
2016
21
Chromosome and Linear Plasmid Sequences of a 2015 Human Isolate of the Tick-Borne Relapsing Fever Spirochete, Borrelia turicatae. ( 27417836 )
2016
22
Tick-borne Relapsing Fever in Children in the North-west of Iran, Qazvin. ( 26445390 )
2015
23
Borrelia miyamotoi: a widespread tick-borne relapsing fever spirochete. ( 25892254 )
2015
24
Case report: a retrospective serological analysis indicating human exposure to tick-borne relapsing Fever spirochetes in Texas. ( 25856342 )
2015
25
Blood transfusion transmission of the tick-borne relapsing fever spirochete Borrelia miyamotoi in mice. ( 25251880 )
2014
26
Postexposure prophylaxis of tick-borne relapsing fever: lessons learned from recent outbreaks in Israel. ( 24107216 )
2013
27
Tick-borne relapsing fever in pregnancy. ( 23939208 )
2013
28
Endemic foci of the tick-borne relapsing fever spirochete Borrelia crocidurae in Mali, West Africa, and the potential for human infection. ( 23209863 )
2012
29
Tick-borne relapsing fever with cutaneous eschar and radiculopathy, Ethiopia. ( 22776391 )
2012
30
A 20-year-old man with fever, headache, and neck stiffness. Neuroborreliosis with tick-borne relapsing fever. ( 21288847 )
2011
31
Tick-borne relapsing fever borreliosis, rural senegal. ( 21529402 )
2011
32
Elevated troponin and jarisch-herxheimer reaction in tick-borne relapsing Fever: a case report. ( 22567483 )
2011
33
Molecular characterization of Borrelia persica, the agent of tick borne relapsing fever in Israel and the Palestinian Authority. ( 21124792 )
2010
34
Post exposure prophylaxis of tick-borne relapsing fever. ( 20012878 )
2010
35
The epidemiology of tick-borne relapsing fever in Iran during 1997-2006. ( 19411042 )
2009
36
Tick-borne relapsing fever: conjunctival haemorrhages. ( 21686925 )
2009
37
Congenital tick-borne relapsing fever: report of a case with transplacental transmission in the Islamic Republic of Iran. ( 19731794 )
2009
38
Tick-borne relapsing fever and Borrelia hermsii, Los Angeles County, California, USA. ( 19624916 )
2009
39
Tick-borne relapsing fever in a new highland endemic focus of western Iran. ( 19695158 )
2009
40
Tick-borne relapsing fever. ( 18755384 )
2008
41
Absence of transovarial transmission of Borrelia duttonii, a tick-borne relapsing fever agent, by the vector tick Ornithodoros moubata. ( 18454593 )
2008
42
Tick talk: unusually severe case of tick-borne relapsing fever with acute respiratory distress syndrome--case report and review of the literature. ( 19099321 )
2008
43
Community knowledge, attitudes and practices related to tick-borne relapsing fever in dodoma rural district, central Tanzania. ( 19024337 )
2008
44
Tick-borne relapsing fever polymerase chain reaction of tick-borne relapsing fever caused by Borrelia hermsii. ( 17484230 )
2007
45
Does tick-borne relapsing fever have an animal reservoir in East Africa? ( 18021022 )
2007
46
Killed in action: microbiologists and clinicians as victims of their occupation. Part 4: Tick-borne Relapsing Fever, Malta Fever, Glanders, SARS. ( 16423683 )
2006
47
Doxycycline for the prevention of tick-borne relapsing fever. ( 17035657 )
2006
48
Immunodominant epitope in the C-terminus of a variable major protein in Borrelia duttonii, an agent of tick-borne relapsing fever. ( 16625051 )
2006
49
Postexposure treatment with doxycycline for the prevention of tick-borne relapsing fever. ( 16837678 )
2006
50
Incidence of tick-borne relapsing fever in west Africa: longitudinal study. ( 16815378 )
2006

Variations for Tick-Borne Relapsing Fever

Expression for Tick-Borne Relapsing Fever

Search GEO for disease gene expression data for Tick-Borne Relapsing Fever.

Pathways for Tick-Borne Relapsing Fever

GO Terms for Tick-Borne Relapsing Fever

Molecular functions related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 double-stranded DNA binding GO:0003690 8.96 GEN1 PURA
2 single-stranded DNA binding GO:0003697 8.62 GEN1 PURA

Sources for Tick-Borne Relapsing Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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