MCID: TCK003
MIFTS: 35

Tick-Borne Relapsing Fever

Categories: Infectious diseases

Aliases & Classifications for Tick-Borne Relapsing Fever

MalaCards integrated aliases for Tick-Borne Relapsing Fever:

Name: Tick-Borne Relapsing Fever 12 15 70 32
Relapsing Fever, Tick-Borne 12 3

Classifications:



External Ids:

Disease Ontology 12 DOID:13036
ICD9CM 34 087.1
NCIt 50 C34976
SNOMED-CT 67 10301003
ICD10 32 A68.1
UMLS 70 C0035022

Summaries for Tick-Borne Relapsing Fever

CDC : 3 Relapsing fever is bacterial infection that can cause recurring bouts of fever, headache, muscle and joint aches, and nausea. There are two types of relapsing fever: Tick-borne relapsing fever (TBRF) Louse-borne relapsing fever (LBRF) TBRF occurs in the western United States and is usually linked to sleeping in rustic, rodent-infested cabins in the mountains. In Texas, TBRF is frequently linked to cave exposures. LBRF is transmitted by the human body louse and usually occurs in refugee settings in developing parts of the world.

MalaCards based summary : Tick-Borne Relapsing Fever, also known as relapsing fever, tick-borne, is related to lyme disease and relapsing fever, and has symptoms including tachycardia, tachypnea and lymphadenopathy. An important gene associated with Tick-Borne Relapsing Fever is CFHR2 (Complement Factor H Related 2), and among its related pathways/superpathways are Immune response Lectin induced complement pathway and Creation of C4 and C2 activators. The drugs Doxycycline and Antiparasitic Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, salivary gland and temporal lobe, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Disease Ontology : 12 A relapsing fever that is characterized by relapsing or recurring episodes of fever, has material basis in Borrelia hermsii, has material basis in Borrelia parkeri or has material basis in Borrelia duttoni, which are transmitted by soft ticks (Ornithodoros parkeri and Ornithodoros hermsii). The infection has symptom tachypnea, has symptom tachycardia, has symptom hepatosplenomegaly and has symptom lymphadenopathy.

Related Diseases for Tick-Borne Relapsing Fever

Diseases related to Tick-Borne Relapsing Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 lyme disease 30.9 CFHR2 C4A C3
2 relapsing fever 29.8 CYP26A1 CLPX CFHR2 CCDC85B C4B C4A
3 tick infestation 11.4
4 thrombocytopenia 10.5
5 meningoencephalitis 10.3
6 bilirubin metabolic disorder 10.3
7 syphilis 10.3
8 splenomegaly 10.3
9 dense deposit disease 10.2 CFHR2 C3
10 c3 glomerulopathy 10.2 CFHR2 C3
11 malaria 10.2
12 human granulocytic anaplasmosis 10.2
13 disease by infectious agent 10.2
14 common cold 10.2
15 disseminated intravascular coagulation 10.2
16 adult respiratory distress syndrome 10.2
17 pyelonephritis 10.2
18 uveitis 10.2
19 glanders 10.2
20 facial paralysis 10.2
21 plasmodium falciparum malaria 10.2
22 severe acute respiratory syndrome 10.2
23 radiculopathy 10.2
24 severe combined immunodeficiency 10.2
25 myocarditis 10.2
26 meningitis 10.2
27 headache 10.2
28 retinal drusen 10.2 CFHR2 C3
29 acute poststreptococcal glomerulonephritis 10.1 CFHR2 C3
30 kuhnt-junius degeneration 10.1 HTRA1 CFHR2
31 progressive relapsing multiple sclerosis 10.1 CFHR2 C3
32 henoch-schoenlein purpura 10.0 CFHR2 C3
33 degeneration of macula and posterior pole 10.0 HTRA1 CFHR2 C3
34 juvenile dermatitis herpetiformis 10.0 C4B C4A
35 immunodeficiency due to a classical component pathway complement deficiency 10.0 C4B C4A
36 immune-complex glomerulonephritis 10.0 CFHR2 C4B C3
37 streptococcus pneumonia 10.0 CFHR2 C3
38 epilepsy, familial temporal lobe, 2 10.0 C4B C4A
39 capillary leak syndrome 10.0 C4A C3
40 afibrinogenemia, congenital 10.0 CFHR2 C4B C3
41 felty syndrome 10.0 C4B C4A
42 hemolytic-uremic syndrome 10.0 CFHR2 C4B C3
43 membranoproliferative glomerulonephritis 9.9 CFHR2 C4A C3
44 complement component 2 deficiency 9.9 C4B C4A
45 iga glomerulonephritis 9.9 CFHR2 C4A C3
46 acrodermatitis chronica atrophicans 9.9 CYP26A1 CLPX CFHR2
47 complement factor i deficiency 9.9 C4B C4A C3
48 blood protein disease 9.9 CFHR2 C4B C4A
49 pediatric systemic lupus erythematosus 9.9 C4B C4A C3
50 lupus erythematosus 9.9 C4B C4A C3

Graphical network of the top 20 diseases related to Tick-Borne Relapsing Fever:



Diseases related to Tick-Borne Relapsing Fever

Symptoms & Phenotypes for Tick-Borne Relapsing Fever

Symptoms:

12
  • tachycardia
  • tachypnea
  • lymphadenopathy
  • hepatosplenomegaly

GenomeRNAi Phenotypes related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-107 9.47 C4A C4B
2 Increased shRNA abundance (Z-score > 2) GR00366-A-137 9.47 CYP26A1
3 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.47 C4A C4B
4 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.47 CYP26A1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.47 CYP26A1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.47 CYP26A1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.47 C4A C4B
8 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.47 C4A C4B
9 Increased shRNA abundance (Z-score > 2) GR00366-A-8 9.47 C4A C4B

Drugs & Therapeutics for Tick-Borne Relapsing Fever

Drugs for Tick-Borne Relapsing Fever (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Doxycycline Approved, Investigational, Vet_approved Phase 2, Phase 3 564-25-0 54671203
2 Antiparasitic Agents Phase 2, Phase 3
3 Anti-Bacterial Agents Phase 2, Phase 3
4 Antimalarials Phase 2, Phase 3
5 Antiprotozoal Agents Phase 2, Phase 3
6 Anti-Infective Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Post Exposure Treatment With Doxycycline for the Prevention of Relapsing Fever Completed NCT00237016 Phase 2, Phase 3 doxycycline treatment

Search NIH Clinical Center for Tick-Borne Relapsing Fever

Genetic Tests for Tick-Borne Relapsing Fever

Anatomical Context for Tick-Borne Relapsing Fever

MalaCards organs/tissues related to Tick-Borne Relapsing Fever:

40
Eye, Salivary Gland, Temporal Lobe, Brain

Publications for Tick-Borne Relapsing Fever

Articles related to Tick-Borne Relapsing Fever:

(show top 50) (show all 349)
# Title Authors PMID Year
1
Aggregation of data from 4 clinical studies demonstrating efficacy of single-dose doxycycline postexposure for prevention of the spirochetal infections: Lyme disease, syphilis, and tick-borne relapsing fever. 61
33360515 2021
2
Borrelia miyamotoi infection in Apodemus spp. mice populating an urban habitat (Warsaw, Poland). 61
33643840 2021
3
Vitronectin binding protein, BOM1093, confers serum resistance on Borrelia miyamotoi. 61
33750855 2021
4
Postexposure prophylaxis with single-dose doxycycline is effective for prevention of Lyme disease in both the United States and Europe and is also effective for prevention of syphilis and tick-borne relapsing fever. 61
33780744 2021
5
Transmission of the human relapsing fever spirochete Borrelia persica by the argasid tick Ornithodoros tholozani involves blood meals from wildlife animal reservoirs and mainly transstadial transfer. 61
33741637 2021
6
Quantitative real-time PCR in Borrelia persica tick-borne relapsing fever demonstrates correlation with the Jarisch-Herxheimer reaction. 61
33394211 2021
7
Detection of Asian-Type Borrelia miyamotoi from Ixodes ricinus Inhabiting Tver Province (Russia): A Sympatric Region for I. ricinus and Ixodes persulcatus. 61
32762621 2020
8
Identification and functional analysis of ferritin 2 from the Taiga tick Ixodes persulcatus Schulze. 61
32993953 2020
9
Doxycycline for Prevention of Spirochetal Infections: Status Report. 61
32157268 2020
10
A case of tick-borne relapsing fever in pregnancy. 61
33316012 2020
11
Single Dose of Doxycycline for the Prevention of Tick-borne Relapsing Fever. 61
31955197 2020
12
Tick-borne relapsing fever. 61
32675137 2020
13
[Tick-borne relapsing fever : An unrecognized cause of fever in travellers]. 61
32014353 2020
14
The Brief Case: Tick-Borne Relapsing Fever in a Returned Traveler. 61
32457233 2020
15
Closing the Brief Case: Tick-Borne Relapsing Fever in a Returned Traveler. 61
32457234 2020
16
Epidemiology of Tick-Borne Relapsing Fever in Endemic Area, Spain. 61
32308194 2020
17
Tick-Borne Relapsing Fever Caused by Borrelia persica in Traveler to Central Asia, 2019. 61
32187006 2020
18
Tick-Borne Diseases in the United States. 61
32232463 2020
19
Development of A Loop-Mediated Isothermal Amplification (LAMP) Assay for Detection of Relapsing Fever Borreliae. 61
32766348 2020
20
Isolation and Molecular Characterization of Tick-Borne Relapsing Fever Borrelia Infecting Ornithodoros (Pavlovskyella) verrucosus Ticks Collected in Ukraine. 61
31573602 2020
21
Prevalence of Infection and Co-Infection and Presence of Rickettsial Endosymbionts in Ixodes Scapularis (Acari: Ixodidae) in Connecticut, USA. 61
31971489 2020
22
Detection of Borrelia crocidurae in a vaginal swab after miscarriage, rural Senegal, Western Africa. 61
31863877 2020
23
Reptile-associated Borrelia spp. In Amblyomma ticks, Thailand. 61
31668984 2020
24
Differential Expression of Putative Ornithodoros turicata Defensins Mediated by Tick Feeding. 61
32477960 2020
25
The impact of in vitro cultivation on the natural life cycle of the tick-borne relapsing fever spirochete Borrelia turicatae. 61
33044963 2020
26
The habitat suitability model for the potential distribution of Ornithodoros tholozani (Laboulbène et Mégnin, 1882) and Ornithodoros lahorensis (Neumann, 1908) (Acari: Argasidae): the main vectors of tick-borne relapsing fever in Iran. 61
33128518 2020
27
A Novel Rapid Sample Preparation Method for MALDI-TOF MS Permits Borrelia burgdorferi Sensu Lato Species and Isolate Differentiation. 61
32373099 2020
28
Erratum: Lopez, J.E., et al. Tick-Borne Relapsing Fever Spirochetes in the Americas. Vet. Sci. 2016, 3, 16. 61
31817297 2019
29
Host Competency of the Multimammate Rat Mastomys natalensis Demonstrated by Prolonged Spirochetemias with the African Relapsing Fever Spirochete Borrelia crocidurae. 61
31674298 2019
30
Borrelia crocidurae tick-borne relapsing fever upon return from Senegal. 61
31202618 2019
31
[Meningitis due to infection with Borrelia hispanica]. 61
31609560 2019
32
Line Immunoblot Assay for Tick-Borne Relapsing Fever and Findings in Patient Sera from Australia, Ukraine and the USA. 61
31640151 2019
33
Evaluating the risk of tick-borne relapsing fever among occupational cavers-Austin, TX, 2017. 61
31152496 2019
34
Antibodies to Borrelia turicatae in Experimentally Infected Dogs Cross-React with Borrelia burgdorferi Serologic Assays. 61
31270181 2019
35
A relapsing fever Borrelia and spotted fever Rickettsia in ticks from an Andean valley, central Chile. 61
31165944 2019
36
Meningitis with cranial polyneuritis and cavernous sinus thrombosis by Borrelia crocidurae: First autochthonous case in Europe. 61
30818047 2019
37
Molecular prevalence and ecoregion distribution of select tick-borne pathogens in Texas dogs. 61
30739394 2019
38
Tick-Borne Relapsing Fever in the White Mountains, Arizona, USA, 2013-2018. 61
30882304 2019
39
Case report: A retrospective serological analysis indicating human exposure to tick-borne relapsing fever spirochetes in Sonora, Mexico. 61
30973877 2019
40
Erratum for Krishnavajhala et al., "Vector Competence of Geographical Populations of Ornithodoros turicata for the Tick-Borne Relapsing Fever Spirochete Borrelia turicatae". 61
30787072 2019
41
An immunocompromised mouse model to infect Ixodes scapularis ticks with the relapsing fever spirochete, Borrelia miyamotoi. 61
30503357 2019
42
Borrelia parkeri in Ornithodoros parkeri (Ixodida: Argasidae) Collected Using Compact Dry Ice Traps in Madera County, California. 61
30517684 2019
43
Novel real-time PCR assays for genomic group identification of tick-borne relapsing fever species Borrelia hermsii. 61
30131238 2019
44
Assessing the Contribution of an HtrA Family Serine Protease During Borrelia turicatae Mammalian Infection. 61
31456953 2019
45
Louse-borne relapsing fever (Borrelia recurrentis infection). 61
30869050 2019
46
Vector Competence of Geographical Populations of Ornithodoros turicata for the Tick-Borne Relapsing Fever Spirochete Borrelia turicatae. 61
30143510 2018
47
Tick-borne relapsing fever as a potential veterinary medical problem. 61
29943903 2018
48
Seroprevalence for the tick-borne relapsing fever spirochete Borrelia turicatae among small and medium sized mammals of Texas. 61
30372445 2018
49
Ixodes scapularis tick distribution and infection rates in Ottawa, Ontario, 2017. 61
31524885 2018
50
Transmission of the relapsing fever spirochete, Borrelia miyamotoi, by single transovarially-infected larval Ixodes scapularis ticks. 61
30007502 2018

Variations for Tick-Borne Relapsing Fever

Expression for Tick-Borne Relapsing Fever

Search GEO for disease gene expression data for Tick-Borne Relapsing Fever.

Pathways for Tick-Borne Relapsing Fever

Pathways related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.74 C4B C4A C3
2
Show member pathways
11.66 C4B C4A C3
3 11.42 C4B C4A C3
4
Show member pathways
11.24 C4B C4A C3
5 11.09 CFHR2 C4B C4A C3
6 11.01 C4B C4A C3

GO Terms for Tick-Borne Relapsing Fever

Cellular components related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.8 C4B C4A C3

Biological processes related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement activation, classical pathway GO:0006958 9.5 C4B C4A C3
2 negative regulation of endopeptidase activity GO:0010951 9.43 C4B C4A C3
3 complement activation GO:0006956 9.33 C4B C4A C3
4 regulation of complement activation GO:0030449 9.26 CFHR2 C4B C4A C3
5 positive regulation of apoptotic cell clearance GO:2000427 8.8 C4B C4A C3

Molecular functions related to Tick-Borne Relapsing Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase inhibitor activity GO:0004866 8.8 C4B C4A C3

Sources for Tick-Borne Relapsing Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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