MCID: TCH005
MIFTS: 28

Tièche-Jadassohn Nevus

Categories: Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Tièche-Jadassohn Nevus

MalaCards integrated aliases for Tièche-Jadassohn Nevus:

Name: Tièche-Jadassohn Nevus 20
Blue Nevus 20 6 17
Benign Mesenchymal Melanoma 20
Jadassohn-Tièche Syndrome 20
Jadassohn-Tièche Nevus 20
Blue Neuronevus 20
Mongolian Spot 71
Nevus, Blue 71

Classifications:



External Ids:

UMLS 71 C0206736 C0265985

Summaries for Tièche-Jadassohn Nevus

MalaCards based summary : Tièche-Jadassohn Nevus, also known as blue nevus, is related to carney complex variant and blue nevi, familial multiple. An important gene associated with Tièche-Jadassohn Nevus is TBX5 (T-Box Transcription Factor 5). The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include cervix, lymph node and prostate.

Wikipedia : 74 Blue nevus (also known as "blue neuronevus", "dermal melanocytoma", "nevus coeruleus" and "nevus bleu")... more...

Related Diseases for Tièche-Jadassohn Nevus

Diseases related to Tièche-Jadassohn Nevus via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 carney complex variant 11.4
2 blue nevi, familial multiple 11.0
3 melanoma 10.7
4 nevus of ota 10.4
5 skin melanoma 10.4
6 spitz nevus 10.4
7 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.3
8 cutaneous fibrous histiocytoma 10.3
9 mongolian spot 10.2
10 neurofibroma 10.2
11 rare tumor 10.2
12 lentigines 10.2
13 melanoma, uveal 10.2
14 dowling-degos disease 1 10.2
15 basal cell carcinoma 10.2
16 blue rubber bleb nevus 10.1
17 nodular malignant melanoma 10.1
18 prostatic hypertrophy 10.1
19 hemangioma 10.1
20 prostatic adenoma 10.1
21 neurilemmoma 10.1
22 melanosis, neurocutaneous 10.1
23 prostatic hyperplasia, benign 10.1
24 microphthalmia 10.1
25 malignant conjunctival melanoma 10.1
26 clear cell sarcoma 10.1
27 posttransplant acute limbic encephalitis 10.1
28 argyria 10.1
29 pilonidal sinus 10.0
30 vitiligo-associated multiple autoimmune disease susceptibility 6 10.0
31 vitiligo-associated multiple autoimmune disease susceptibility 1 10.0
32 meningioma, familial 10.0
33 epidermolysis bullosa, nonspecific, autosomal recessive 10.0
34 cervical polyp 10.0
35 spitzoid melanoma 10.0
36 sarcoma 10.0
37 spinal meningioma 10.0
38 leiomyoma 10.0
39 malignant spindle cell melanoma 10.0
40 skin benign neoplasm 10.0
41 melanotic neurilemmoma 10.0
42 spindle cell sarcoma 10.0
43 secretory meningioma 10.0
44 lymphoplasmacyte-rich meningioma 10.0
45 cutis verticis gyrata 10.0
46 esophageal cancer 9.8
47 retinal detachment 9.8
48 adenomyosis 9.8
49 leukemia, acute lymphoblastic 9.8
50 deficiency anemia 9.8

Symptoms & Phenotypes for Tièche-Jadassohn Nevus

Drugs & Therapeutics for Tièche-Jadassohn Nevus

Drugs for Tièche-Jadassohn Nevus (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030
4 Immunosuppressive Agents Phase 4
5 Antifungal Agents Phase 4
6 Antibiotics, Antitubercular Phase 4
7 Anti-Infective Agents Phase 4
8 Immunologic Factors Phase 4
9 Anti-Bacterial Agents Phase 4
10
Formaldehyde Approved, Vet_approved 50-00-0 712
11 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy of Rapamycin (Sirolimus) in the Treatment of Blue Rubber Bleb Nevus Syndrome, Hereditary or Sporadic Venous Malformation Recruiting NCT03767660 Phase 4 Rapamycin
2 A Multicenter, Ambispective, Low-interventional Clinical Study Evaluating Molecular Genetic Markers for Non-invasive Differential Diagnosis of Benign and Malignant Pigmented Skin and Mucosal Neoplasms Recruiting NCT04353050

Search NIH Clinical Center for Tièche-Jadassohn Nevus

Genetic Tests for Tièche-Jadassohn Nevus

Anatomical Context for Tièche-Jadassohn Nevus

MalaCards organs/tissues related to Tièche-Jadassohn Nevus:

40
Cervix, Lymph Node, Prostate, Skin, Smooth Muscle, Ovary, Uterus

Publications for Tièche-Jadassohn Nevus

Articles related to Tièche-Jadassohn Nevus:

(show top 50) (show all 686)
# Title Authors PMID Year
1
Clinicopathological study of blue nevi of the gastrointestinal (GI) tract: first case series. 61
32631943 2021
2
Agminated Blue Nevus: GNAQ Mutations and Beyond. 61
33022225 2021
3
Atypical Cellular Blue Nevus With Necrosis Mimicking Melanoma Ex-Blue Nevus. 61
33534207 2021
4
Subcutaneous nodule showing loss of BAP1 in large plaque-type blue nevus: Melanoma or not? 61
32881031 2020
5
Subungual blue nevus. 61
33210390 2020
6
Disseminated Eruptive Blue Nevi in a Young Adult Patient. 61
33282575 2020
7
A successfully treated malignant melanoma arising in a large congenital vulvar blue nevus. 61
32531081 2020
8
Melanoma Ex Blue Nevus With GNA11 Mutation and BAP1 Loss: Case Report and Review of the Literature. 61
32310862 2020
9
Efficacy of Electrochemotherapy in the Treatment of Cutaneous Melanoma Metastases and Rare Non-melanoma Skin Cancer. 61
33109587 2020
10
Uterine Cellular Blue Nevus Arising in Mullerian and Pelvic Dendritic Melanocytosis: Case Report of a Rare Phenomenon to Be Distinguished From Uterine Melanoma. 61
32925442 2020
11
Primary orbital melanoma: A report of a case and comprehensive review of the literature. 61
32900269 2020
12
Nail Unit Blue Nevi: A 11-Case Series and Review of the Literature. 61
33088814 2020
13
Diagnostic value of dermoscopy combined with reflectance confocal microscopy for clinically equivocal blue nevus. 61
32804731 2020
14
Intra-Scleral Blue Nevus Arising within Oculodermal Melanocytosis: Melanoma or Not? 61
33005617 2020
15
Blue nevus of the nail: A case report and review. 61
32500667 2020
16
Genomic and Clinicopathologic Characteristics of PRKAR1A-inactivated Melanomas: Toward Genetic Distinctions of Animal-type Melanoma/Pigment Synthesizing Melanoma. 61
32118628 2020
17
BAP-1 Expression Status by Immunohistochemistry in Cellular Blue Nevus and Blue Nevus-like Melanoma. 61
32310893 2020
18
Compound blue nevus: a reappraisal of the concept in the genomic era. 61
31754815 2020
19
Blue nevus with satellitosis: a case report in a pregnant patient. 61
32041936 2020
20
Blue Nevus With Rosettes on Polarized Light Dermoscopy. 61
31921504 2020
21
GNAQQ209L expression initiated in multipotent neural crest cells drives aggressive melanoma of the central nervous system. 61
31680437 2020
22
Treatment response to checkpoint immunotherapy in a patient with a melanoma ex blue nevus. 61
31518011 2020
23
Blue Rubber Bleb Nevus Syndrome With Multiple Cavernoma-Like Lesions on MRI: A Familial Case Report and Literature Review. 61
32318009 2020
24
Dermoscopic rainbow pattern: A strong clue to malignancy or just a light show? 61
33163886 2020
25
Generalized congenital epithelioid blue nevi (pigmented epithelioid melanocytomas) in an infant: Report of case and review of the literature. 61
31283031 2019
26
CYSLTR2-mutant Cutaneous Melanocytic Neoplasms Frequently Simulate "Pigmented Epithelioid Melanocytoma," Expanding the Morphologic Spectrum of Blue Tumors: A Clinicopathologic Study of 7 Cases. 61
31162285 2019
27
Blue Nevus Developing at a Combined Tetanus, Diphtheria, and Pertussis (Tdap) Vaccination Site: Case Report and Summary of Vaccine-Associated Cutaneous Lesions. 61
31497428 2019
28
Nevus of Ota - an intraoral presentation: a case report. 61
31171040 2019
29
Melanocytoma of the Conjunctiva: Clinicopathologic Features of Three Cases. 61
31367593 2019
30
A cellular blue nevus with pigmented epithelioid melanocytoma-like pattern on the ipsilateral upper arm associated with a congenital plaque-type blue nevus on the hand. 61
30719746 2019
31
A diagnostically-challenging case of melanoma ex blue nevus with comprehensive molecular analysis, including the 23-gene expression signature (myPath melanoma). 61
30506910 2019
32
Use of Targeted Next-Generation Sequencing to Identify Activating Hot Spot Mutations in Cherry Angiomas. 61
30601876 2019
33
Agminated blue nevus with a GNAQ mutation: A case report and review of the literature. 61
30315589 2019
34
Osteoma Cutis Arising in Common Blue Nevus (Blue Osteonevus): A Clinicopathologic, Immunohistochemical, and Dermoscopic Study. 61
29933316 2019
35
Atypical Cellular Blue Nevus of the Foot: A Case Report. 61
31049319 2019
36
Blue nevus-like melanoma of the uterine cervix. Case report and review of the literature. 61
32239111 2019
37
Unusual melanoma of the scalp with blue nevus-like features and local metastasis: A case report. 61
31065360 2019
38
Integrated Genomic Classification of Melanocytic Tumors of the Central Nervous System Using Mutation Analysis, Copy Number Alterations, and DNA Methylation Profiling. 61
29891723 2018
39
Blue Nevi of the Ocular Surface: Clinical Characteristics, Pathologic Features, and Clinical Course. 61
29551421 2018
40
ALK Rearrangements Are Infrequent in Cellular Blue Nevus and Deep Penetrating Nevus. 61
29923908 2018
41
Metastatic Blue Nevus-Like Melanoma Detected by Liquid-Based Catheterized Urine Cytology. 61
29853754 2018
42
Orbital melanocytoma: When a tumor becomes a relieving surprise. 61
29687085 2018
43
Microphthalmia-associated transcription factor (MiTF): Promiscuous staining patterns in fibrohistiocytic lesions is a potential pitfall. 61
29773427 2018
44
Nevus Blue as a Sporadic Finding in a Patient with a Blue Toe? 61
29875860 2018
45
Blue Nevus With Satellite Lesions Mimicking Malignant Melanoma. 61
29074142 2018
46
Solitary pigmented lesions in oral mucosa in Latin American children: A case series. 61
29573458 2018
47
[Cellular blue nevus in lymph node parenchyma: report of a case]. 61
29534366 2018
48
Malignant Blue Nevus: A Challenge for Dermatologists and Dermatopathologists. 61
28963027 2018
49
Genomic Assessment of Blitz Nevi Suggests Classification as a Subset of Blue Nevus Rather Than Spitz Nevus: Clinical, Histopathologic, and Molecular Analysis of 18 Cases. 61
28475519 2018
50
Subungual Blue Nevus. 61
29017704 2018

Variations for Tièche-Jadassohn Nevus

ClinVar genetic disease variations for Tièche-Jadassohn Nevus:

6
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TBX5 NM_000192.3(TBX5):c.253C>A (p.Pro85Thr) SNV Likely pathogenic 626359 rs1565941579 12:114837427-114837427 12:114399622-114399622

Expression for Tièche-Jadassohn Nevus

Search GEO for disease gene expression data for Tièche-Jadassohn Nevus.

Pathways for Tièche-Jadassohn Nevus

GO Terms for Tièche-Jadassohn Nevus

Sources for Tièche-Jadassohn Nevus

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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