MCID: TMT006
MIFTS: 28

Timothy Grass Allergy

Categories: Immune diseases

Aliases & Classifications for Timothy Grass Allergy

MalaCards integrated aliases for Timothy Grass Allergy:

Name: Timothy Grass Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060498

Summaries for Timothy Grass Allergy

Disease Ontology : 12 A pollen allergy triggered by Phleum pratense pollen.

MalaCards based summary : Timothy Grass Allergy is related to conjunctivitis and rhinitis. An important gene associated with Timothy Grass Allergy is PDCL (Phosducin Like), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. Affiliated tissues include lung, skin and eye, and related phenotypes are homeostasis/metabolism and digestive/alimentary

Related Diseases for Timothy Grass Allergy

Diseases related to Timothy Grass Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 318)
# Related Disease Score Top Affiliating Genes
1 conjunctivitis 29.2 RNASE3 PTGDR2 IL5 IL4 IL13 IL10
2 rhinitis 29.0 RNASE3 IL5 IL4 IL17A IL13 IL10
3 allergic rhinitis 29.0 RNASE3 IL5 IL4 IL17A IL13 IL10
4 tomato allergy 10.4 PDCL PDC
5 apple allergy 10.4 PDCL PDC
6 peach allergy 10.4 PDCL PDC
7 fish allergy 10.4 PDCL PDC
8 melon allergy 10.3 PDCL PDC
9 cytokine deficiency 10.3 IL5 IL13
10 aztreonam allergy 10.3 IL5 IL13
11 cefaclor allergy 10.3 IL5 IL13
12 cefuroxime allergy 10.3 IL5 IL13
13 angioimmunoblastic lymphadenopathy with dysproteinemia 10.3 IL5 IL13
14 respiratory syncytial virus infectious disease 10.3 IL5 IL13
15 loeffler syndrome 10.3 IL5 IL13
16 loeffler endocarditis 10.3 RNASE3 IL5
17 eosinophilic gastritis 10.3 IL5 IL13
18 toxic oil syndrome 10.2 IL5 IL4
19 childhood-onset asthma 10.2 RNASE3 IL13
20 exercise-induced bronchoconstriction 10.2 RNASE3 IL13
21 neurodermatitis 10.2 IL4 IL13
22 exanthem 10.2
23 angioedema 10.2
24 dysphagia 10.2
25 disseminated eosinophilic collagen disease 10.1 RNASE3 IL5
26 pemphigoid 10.1 IL5 IL4 IL13
27 angiostrongyliasis 10.1 IL5 IL4 IL13
28 orange allergy 10.1 PDCL PDC IL5 IL13
29 paragonimiasis 10.1 RNASE3 IL5 IL13
30 vasomotor rhinitis 10.1 RNASE3 IL5 IL13
31 posterior uveitis 10.1 IL5 IL4 IL13
32 acute asthma 10.1 RNASE3 IL5 IL4
33 vernal conjunctivitis 10.1 RNASE3 IL4
34 mononeuritis multiplex 10.1 IL5 CD4
35 atopic keratoconjunctivitis 10.1 RNASE3 IL5 IL4
36 prurigo nodularis 10.1 RNASE3 IL17A
37 cough variant asthma 10.1 RNASE3 IL5 IL4
38 blepharoconjunctivitis 10.1 IL4 CD4
39 patulous eustachian tube 10.1 RNASE3 IL5
40 eosinophilic gastroenteritis 10.1 RNASE3 IL5 IL4
41 silo filler's disease 10.1 IL5 IL17A
42 pemphigoid gestationis 10.1 RNASE3 IL5
43 chronic meningitis 10.1 IL5 IL13 CD4
44 diphtheria 10.1 IL5 IL4 IL13
45 drug allergy 10.1 IL5 IL13 CD4
46 nut allergy 10.0 PDCL IL5 IL4 IL13
47 asymptomatic neurosyphilis 10.0 IL17A CD4
48 meningovascular neurosyphilis 10.0 IL17A CD4
49 retinitis pigmentosa 46 10.0 IL4 CD4
50 transient arthritis 10.0 IL17A CD4

Graphical network of the top 20 diseases related to Timothy Grass Allergy:



Diseases related to Timothy Grass Allergy

Symptoms & Phenotypes for Timothy Grass Allergy

MGI Mouse Phenotypes related to Timothy Grass Allergy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 CA2 CD4 GAD2 GALC IL10 IL13
2 digestive/alimentary MP:0005381 9.97 CA2 CD4 GAD2 IL10 IL13 IL17A
3 immune system MP:0005387 9.9 CA2 CD4 GAD2 GALC IL10 IL13
4 no phenotypic analysis MP:0003012 9.5 CD4 GAD2 IL10 IL13 IL17A IL4
5 respiratory system MP:0005388 9.17 CA2 GAD2 IL10 IL13 IL17A IL4

Drugs & Therapeutics for Timothy Grass Allergy

Search Clinical Trials , NIH Clinical Center for Timothy Grass Allergy

Genetic Tests for Timothy Grass Allergy

Anatomical Context for Timothy Grass Allergy

MalaCards organs/tissues related to Timothy Grass Allergy:

40
Lung, Skin, Eye, Bone, Lymph Node, Spinal Cord

Publications for Timothy Grass Allergy

Articles related to Timothy Grass Allergy:

# Title Authors PMID Year
1
The correlation between intradermal testing and serum specific IgE to house dust mite in negative skin prick test allergic rhinitis adult patients. 61
26708395 2015
2
The efficacy and safety of the Timothy grass allergy sublingual immunotherapy tablet in Canadian adults and children. 61
25685162 2014
3
Efficacy and safety of timothy grass allergy immunotherapy tablet treatment in North American adults. 61
21211643 2011
4
Efficacy and safety of timothy grass allergy immunotherapy tablets in North American children and adolescents. 61
21211642 2011

Variations for Timothy Grass Allergy

Expression for Timothy Grass Allergy

Search GEO for disease gene expression data for Timothy Grass Allergy.

Pathways for Timothy Grass Allergy

Pathways related to Timothy Grass Allergy according to GeneCards Suite gene sharing:

(show all 24)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.16 IL5 IL4 IL17A IL13 IL10 CD4
2
Show member pathways
12.6 RNASE3 IL5 IL4 IL17A IL13 IL10
3
Show member pathways
12.45 IL5 IL4 IL17A IL10 CD4
4
Show member pathways
12.45 IL5 IL4 IL17A IL13 IL10 CD4
5
Show member pathways
12.28 IL5 IL4 IL13 IL10
6
Show member pathways
12.19 IL5 IL4 IL17A IL13
7
Show member pathways
12.1 IL5 IL4 IL17A IL13 IL10
8 11.87 PTGDR2 IL5 IL4 IL10 CD4
9 11.84 IL4 IL17A IL13 IL10
10 11.78 IL5 IL4 CD4
11
Show member pathways
11.74 IL4 IL17A CD4
12 11.68 IL5 IL4 IL13
13
Show member pathways
11.63 IL17A IL10 CD4
14 11.56 IL5 IL4 IL10
15 11.52 IL5 IL4 IL13
16 11.51 IL5 IL4 IL10
17 11.39 IL4 IL13 IL10
18 11.22 IL5 IL4 IL13 IL10 CD4
19 11.17 IL5 IL4 IL17A IL13
20 11.07 PTGDR2 IL5 IL4 IL17A IL13 IL10
21 11.04 IL5 IL4 IL13 IL10
22 10.9 IL5 IL4 IL17A IL13 IL10
23 10.82 IL5 IL4 IL13 IL10 CD4
24 10.71 IL5 IL4 IL13

GO Terms for Timothy Grass Allergy

Cellular components related to Timothy Grass Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 RNASE3 IL5 IL4 IL17A IL13 IL10

Biological processes related to Timothy Grass Allergy according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-negative bacterium GO:0050829 9.69 RNASE3 IL17A CD4
2 B cell differentiation GO:0030183 9.67 IL4 IL10 GPS2
3 positive regulation of B cell proliferation GO:0030890 9.61 IL5 IL4 IL13
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.58 IL4 IL13 IL10
5 negative regulation of inflammatory response GO:0050728 9.56 IL4 IL13 IL10 GPS2
6 macrophage activation GO:0042116 9.54 IL4 IL13
7 positive regulation of MHC class II biosynthetic process GO:0045348 9.52 IL4 IL10
8 positive regulation of mast cell degranulation GO:0043306 9.48 IL4 IL13
9 type 2 immune response GO:0042092 9.46 IL4 IL10
10 cytokine-mediated signaling pathway GO:0019221 9.43 IL5 IL4 IL17A IL13 IL10 CD4
11 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL4 IL13
12 positive regulation of immunoglobulin production GO:0002639 9.33 IL5 IL13 IL10
13 regulation of isotype switching GO:0045191 9.32 IL4 IL10
14 immune response GO:0006955 9.17 PTGDR2 IL5 IL4 IL17A IL13 IL10

Molecular functions related to Timothy Grass Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IL5 IL4 IL17A IL13 IL10

Sources for Timothy Grass Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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