MCID: TNC003
MIFTS: 39

Tinea Corporis

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Tinea Corporis

MalaCards integrated aliases for Tinea Corporis:

Name: Tinea Corporis 12 15 71 32
Dermatophytosis of the Trunk 12
Dermatophytosis of the Body 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12179
ICD9CM 34 110.5
ICD10 32 B35.4
UMLS 71 C0040252 C0546826

Summaries for Tinea Corporis

Disease Ontology : 12 A dermatophytosis that results in fungal infection located in skin, limited to the stratum corneum of the epidermis, has material basis in Ascomycota fungi that belong to a group called dermatophytes and has symptom itching, and has symptom red colored skin rash. The border of the rash lesions look scaly.

MalaCards based summary : Tinea Corporis, also known as dermatophytosis of the trunk, is related to tinea profunda and dermatomycosis, and has symptoms including itching and red colored skin rash. An important gene associated with Tinea Corporis is SQLE (Squalene Epoxidase), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS). The drugs Naftifine and Luliconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and t cells.

Wikipedia : 74 Tinea corporis, also known as ringworm, is a superficial fungal infection (dermatophytosis) of the arms... more...

Related Diseases for Tinea Corporis

Diseases related to Tinea Corporis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 116)
# Related Disease Score Top Affiliating Genes
1 tinea profunda 32.1 CLEC6A CLEC4E CARD9
2 dermatomycosis 31.3 CBSL B4GALNT2
3 tinea capitis 30.7 SQLE CLEC6A CBSL CARD9 B4GALNT2
4 tinea manuum 30.7 CBSL B4GALNT2
5 contact dermatitis 30.6 KRT16 IL31 FLG
6 discoid lupus erythematosus 30.6 KRT16 FLG
7 tinea pedis 30.5 SQLE DEFB4A CLEC6A CBSL CARD9 B4GALNT2
8 lichen planus 30.4 KRT16 FLG DEFB4A
9 cutaneous candidiasis 30.4 CLEC6A CARD9 B4GALNT2
10 dermatitis 30.3 KRT16 IL31 FLG
11 skin disease 30.2 KRT17 KRT16 IL31 FLG DEFB4A
12 seborrheic dermatitis 30.2 FLG DEFB4A CLEC4E
13 psoriasis 30.0 KRT17 KRT16 IL31 FLG DEFB4A
14 superficial mycosis 30.0 CLEC6A CLEC4E CBSL B4GALNT2
15 tinea unguium 29.9 SQLE FLNA CBSL B4GALNT2
16 tinea cruris 29.9 SQLE FLNA DEFB4A CLEC6A CBSL CARD9
17 pityriasis versicolor 29.9 SQLE CLEC6A CLEC4E CBSL
18 dermatophytosis 29.8 SQLE FLNA DEFB4A CLEC6A CLEC4E CBSL
19 fungal infectious disease 29.8 CLEC6A CLEC4E CBSL CARD9 B4GALNT2
20 scabies 28.9 IL31 FLNA FLG AADACL3
21 tinea imbricata 11.8
22 exanthem 10.4
23 pustulosis of palm and sole 10.4
24 focal palmoplantar keratoderma 10.4 KRT17 KRT16
25 immune deficiency disease 10.4
26 cutaneous lupus erythematosus 10.4
27 ichthyosis 10.4
28 impetigo 10.4
29 herpes zoster 10.4
30 lupus erythematosus 10.4
31 alopecia 10.4
32 subacute cutaneous lupus erythematosus 10.4
33 median rhomboid glossitis 10.4 KRT17 KRT16
34 glossitis 10.4 KRT17 KRT16
35 pachyonychia congenita 2 10.4 KRT17 KRT16
36 palmoplantar keratoderma, nonepidermolytic, focal or diffuse 10.3 KRT17 KRT16
37 white piedra 10.3 CBSL B4GALNT2
38 mycosis fungoides 10.3
39 dermatitis, atopic 10.3
40 otomycosis 10.3 CBSL B4GALNT2
41 trichosporonosis 10.3 CBSL B4GALNT2
42 eumycotic mycetoma 10.3 CBSL B4GALNT2
43 otitis externa 10.2 CBSL B4GALNT2
44 external ear disease 10.2 CBSL B4GALNT2
45 steatocystoma multiplex 10.2 KRT17 KRT16
46 sporotrichosis 10.2 CBSL CARD9
47 mucormycosis 10.2 CARD9 B4GALNT2
48 corneal ulcer 10.2 CLEC6A B4GALNT2
49 vulvovaginal candidiasis 10.2 DEFB4A CLEC6A CARD9
50 psoriasis 15 10.2 IL31 DEFB4A

Graphical network of the top 20 diseases related to Tinea Corporis:



Diseases related to Tinea Corporis

Symptoms & Phenotypes for Tinea Corporis

Symptoms:

12
  • itching
  • red colored skin rash

Drugs & Therapeutics for Tinea Corporis

Drugs for Tinea Corporis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Naftifine Approved Phase 4 65472-88-0 47641 73342
2
Luliconazole Approved Phase 4 187164-19-8
3
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
4
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
5
Itraconazole Approved, Investigational Phase 4 84625-61-6 55283
6 Antifungal Agents Phase 4
7 Anti-Infective Agents Phase 4
8 Hormone Antagonists Phase 4
9 Cytochrome P-450 Enzyme Inhibitors Phase 4
10 Hormones Phase 4
11
Hydroxyitraconazole Phase 4
12 Cytochrome P-450 CYP3A Inhibitors Phase 4
13 Dermatologic Agents
14 Senna
15 Sennoside A&B

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-Label, Multi-Center, Multiple-Application Pharmacokinetic Study of Naftin® (Naftifine Hydrochloride) Cream, 2% in Pediatric Subjects With Tinea Corporis Completed NCT02466867 Phase 4 Naftin® Cream, 2% (younger pediatric cohort);Naftin® Cream, 2% (older pediatric cohort)
2 A Randomized, Multi-Center, Double-Blind, Vehicle-Controlled Study Evaluating the Safety and Efficacy of Product 33525 in Pediatric Subjects With Tinea Corporis Completed NCT02767947 Phase 4 Luliconazole Cream 1%;Vehicle Cream
3 A Phase 4, Double-Blind, Randomized, Vehicle-Controlled, Multicenter, Parallel Group Evaluation of the Efficacy and Safety of Naftin (Naftifine Hydrochloride) Cream, 2% in Pediatric Subjects With Tinea Corporis Completed NCT02227290 Phase 4 Naftin Cream;Placebo Cream
4 Itraconazole in the Management of Superficial Fungal Infections in India. A Pilot Study Recruiting NCT03923010 Phase 4 Itraconazole
5 An Open-Label Study to Evaluate the Safety of Long-Term Administration of Product 33525 in Subjects With Tinea Pedis, Tinea Corporis, or Tinea Cruris Completed NCT01349998 Phase 3 Product 33525
6 Evaluation of Preclinical Toxicity of a Siddha Formulation Kandhaga Rasayanam ( KR ) and Its Therapeutic Efficacy in Padarthamarai ( Dermatophytoses ) by an Open Clinical Trial Completed NCT02238912 Phase 2 kandhaga rasayanam
7 Tele-dermatology of Skin Cancer: a Randomized Trial Comparing Remote Assessment With Conventional Visits in a Cohort of Local Health Authority Employees in the Province of Bergamo (the Shoot the Mole Study) Completed NCT02902822
8 Senna Alata Leaf Decoction as a Treatment for Tinea Imbricata in an Indigenous Tribe in Southern Philippines :a Pilot Study Completed NCT03745183

Search NIH Clinical Center for Tinea Corporis

Genetic Tests for Tinea Corporis

Anatomical Context for Tinea Corporis

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Corporis:

19
Skin

MalaCards organs/tissues related to Tinea Corporis:

40
Skin, Testes, T Cells, Bone, Lung, Thyroid, Breast

Publications for Tinea Corporis

Articles related to Tinea Corporis:

(show top 50) (show all 779)
# Title Authors PMID Year
1
Congenital ichthyosis associated with Trichophyton rubrum tinea, imitating drug hypersensitivity reaction. 61
32547912 2020
2
Limited effectiveness of four oral antifungal drugs (fluconazole, griseofulvin, itraconazole and terbinafine) in the current epidemic of altered dermatophytosis in India: results of a randomized pragmatic trial. 61
32538466 2020
3
Dermatoscopy of tinea corporis. 61
32034804 2020
4
Atypical extensive tinea corporis caused by Trichophyton tonsurans. 61
32497801 2020
5
Nannizzia incurvata as a rare cause of favus and tinea corporis in Cambodia and Vietnam. 61
32525102 2020
6
Varicella and herpes zoster appearing over sites of tinea corporis, hitherto unreported examples of immunocompromised districts: a case series. 61
32072634 2020
7
Epidemiological survey of 42 403 dermatophytosis cases examined at Nagasaki University Hospital from 1966 to 2015. 61
32293052 2020
8
Trichophyton indotineae sp. nov.: A New Highly Terbinafine-Resistant Anthropophilic Dermatophyte Species. 61
32449054 2020
9
Molecular epidemiology of Tinea gladiatorum in contact sports in northern Iran. 61
32096252 2020
10
Species distribution of the main aetiologic agents causing skin dermatophytosis in Colombian patients: A 23-year experience at a Mycological Reference Center. 61
32163641 2020
11
A prospective study on patterns of topical steroids self-use in dermatophytoses and determinants predictive of cutaneous side effects. 61
32449316 2020
12
[Microsporum ferrugineum-an anthropophilic dermatophyte in Germany : Case report and review of the literature]. 61
32394081 2020
13
Tinea Corporis-associated Erythroderma: Case Report and Review of Erythrodermic Patients with Chronic Dermatophyte Infection. 61
32391227 2020
14
Case of tinea corporis due to terbinafine-resistant Trichophyton interdigitale. 61
31994232 2020
15
Tinea Gladiatorum and Dermatophyte Contamination Among Wrestlers and in Wrestling Halls: A Systematic Review and Meta-analysis. 61
31773190 2020
16
In Vitro and Ex Vivo Antibiofilm Activity of a Lipopeptide Biosurfactant Produced by the Entomopathogenic Beauveria bassiana Strain against Microsporum canis. 61
32050410 2020
17
Whole-genome resequencing of Trichophyton rubrum provides insights into population differentiation and drug resistance. 61
31538279 2020
18
A mycological study of tinea corporis: A changing epidemiological trend from Trichophyton rubrum to Trichophyton mentagrophytes in India. 61
32068195 2020
19
A case of tinea corporis by Epidermophyton floccosum mimicking Herpes zoster. 61
32041938 2020
20
Skin Infections and Outpatient Burn Management: Fungal and Viral Skin Infections. 61
31995350 2020
21
Analysis of cases managed by dermatological service in the Chinese peacekeeping level 1+ medical treatment facility in Lebanon, 2018-2019. 61
32111673 2020
22
Image Gallery: Widespread erosive tinea corporis mimicking autoimmune bullous dermatoses in a patient with lung cancer. 61
31598958 2020
23
Atypical Tinea Corporis Revealing a Human Immunodeficiency Virus Infection. 61
32042525 2020
24
Molecular identification of isolates of the Trichophyton mentagrophytes complex. 61
31929737 2020
25
A comment on "First report of tinea corporis caused by Arthroderma benhamiae in Brazil". 61
31898250 2020
26
Tinea Corporis Bullosa Secondary to Trichophyton Verrucosum: A Newer Etiological Agent with Literature Review. 61
32029951 2020
27
Prevalence and clinical characteristics of itch in epidemic-like scenario of dermatophytoses in India: a cross-sectional study. 61
31419346 2020
28
Clinicomycological Study of Dermatophytosis in a Tertiary Care Hospital in Eastern India: A Cross-sectional Study. 61
32055508 2020
29
Epidemiology of Dermatophyte and Non-Dermatophyte Fungi Infection in Ethiopia. 61
32308463 2020
30
A unique multidrug-resistant clonal Trichophyton population distinct from Trichophyton mentagrophytes/Trichophyton interdigitale complex causing an ongoing alarming dermatophytosis outbreak in India: Genomic insights and resistance profile. 61
31491507 2019
31
Tinea corporis caused by Trichophyton equinum transmitted from asymptomatic dogs to two siblings. 61
31820297 2019
32
A new mutation in the SQLE gene of Trichophyton mentagrophytes associated to terbinafine resistance in a couple with disseminated tinea corporis. 61
31611164 2019
33
Epidemiology of dermatophytic infections between 2008 and 2017 in Barcelona, Spain. 61
31076176 2019
34
[Extensive tinea corporis due to a terbinafine-resistant Trichophyton mentagrophytes isolate of the Indian genotype in a young infant from Bahrain in Germany]. 61
31098692 2019
35
Trichophyton mentagrophytes and T interdigitale genotypes are associated with particular geographic areas and clinical manifestations. 61
31444823 2019
36
Pemphigus Herpetiformis Masquerading as Tinea Corporis. 61
31807461 2019
37
The prevalence of scabies, pyoderma and other communicable dermatoses in the Bijagos Archipelago, Guinea-Bissau. 61
31738757 2019
38
Antifungal resistance in dermatophytes: Recent trends and therapeutic implications. 61
31330295 2019
39
First report of tinea corporis caused by Arthroderma benhamiae in Brazil. 61
31463867 2019
40
Epidemiology of dermatomycoses in southwest Poland, years 2011-2016. 61
31839778 2019
41
Epidemiology and dermatological comorbidity of seborrhoeic dermatitis: population-based study in 161 269 employees. 61
30802934 2019
42
Can Dermoscopy Serve as a Diagnostic Tool in Dermatophytosis? A Pilot Study. 61
31544071 2019
43
Two Rare Cases of Tinea Corporis Caused by Trichophyton verrucosum and Trichophyton interdigitale in a Teenage Girl. 61
31598432 2019
44
[Influence of nutrition, common autoimmune diseases and smoking on the incidence of foot mycoses]. 61
31172201 2019
45
Changing Trend of Superficial Mycoses with Increasing Nondermatophyte Mold Infection: A Clinicomycological Study at a Tertiary Referral Center in Assam. 61
31516133 2019
46
Profile of Dermatophytosis in a Tertiary Care Center in Kerala, India. 61
31516134 2019
47
Epidemiology of dermatophytosis in northeastern Iran; A subtropical region. 61
31321333 2019
48
Tinea corporis infection manifestating as retinochoroiditis-an unusual presentation. 61
31131426 2019
49
Dermatophytoses and spectrum of dermatophytes in patients attending a teaching hospital in Western Rajasthan, India. 61
31143732 2019
50
Evaluation of efficacy and safety of oral terbinafine and itraconazole combination therapy in the management of dermatophytosis. 61
31030594 2019

Variations for Tinea Corporis

Expression for Tinea Corporis

Search GEO for disease gene expression data for Tinea Corporis.

Pathways for Tinea Corporis

GO Terms for Tinea Corporis

Cellular components related to Tinea Corporis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.8 KRT17 KRT16 FLG

Biological processes related to Tinea Corporis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 IL31 CLEC6A CLEC4E CLEC4D CARD9
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.65 FLNA CLEC6A CARD9
3 innate immune response GO:0045087 9.65 KRT16 CLEC6A CLEC4E CLEC4D CARD9
4 cornification GO:0070268 9.5 KRT17 KRT16 FLG
5 positive regulation of cytokine secretion GO:0050715 9.46 CLEC6A CLEC4E
6 establishment of skin barrier GO:0061436 9.43 KRT16 FLG
7 morphogenesis of an epithelium GO:0002009 9.4 KRT17 KRT16
8 Fc-gamma receptor signaling pathway GO:0038094 9.16 CLEC4E CLEC4D
9 T cell differentiation involved in immune response GO:0002292 8.96 CLEC4E CLEC4D
10 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.92 CLEC6A CLEC4E CLEC4D CARD9

Molecular functions related to Tinea Corporis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.13 CLEC6A CLEC4E CLEC4D
2 structural molecule activity GO:0005198 8.8 KRT17 KRT16 FLG

Sources for Tinea Corporis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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