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MCID: TNC003
MIFTS: 40

Tinea Corporis

Categories: Infectious diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Tinea Corporis

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MalaCards integrated aliases for Tinea Corporis:

Name: Tinea Corporis 12 15 70 32
Dermatophytosis of the Trunk 12
Dermatophytosis of the Body 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:12179
ICD9CM 34 110.5
SNOMED-CT 67 186994008
ICD10 32 B35.4
UMLS 70 C0040252 C0546826
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Summaries for Tinea Corporis

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Disease Ontology : 12 A dermatophytosis that results in fungal infection located in skin, limited to the stratum corneum of the epidermis, has material basis in Ascomycota fungi that belong to a group called dermatophytes and has symptom itching, and has symptom red colored skin rash. The border of the rash lesions look scaly.

MalaCards based summary : Tinea Corporis, also known as dermatophytosis of the trunk, is related to tinea profunda and tinea cruris, and has symptoms including itching and red colored skin rash. An important gene associated with Tinea Corporis is SQLE (Squalene Epoxidase), and among its related pathways/superpathways are Keratinization and Tuberculosis. The drugs Clotrimazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, bone marrow and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 73 Tinea corporis, also known as ringworm, is a superficial fungal infection (dermatophytosis) of the arms... more...

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Related Diseases for Tinea Corporis

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Diseases related to Tinea Corporis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)
# Related Disease Score Top Affiliating Genes
1 tinea profunda 31.4 CLEC7A CLEC6A CLEC4E CARD9
2 tinea cruris 31.4 SQLE DEFB4A CLEC6A CARD9
3 dermatophytosis 31.1 SQLE DEFB4A CLEC7A CLEC6A CLEC4E CARD9
4 tinea pedis 30.5 SQLE DEFB4A CLEC7A CLEC6A CARD9
5 tinea capitis 30.4 SQLE CLEC7A CLEC6A CLEC4E CARD9
6 discoid lupus erythematosus 30.3 KRT16 FLG
7 contact dermatitis 30.3 KRT16 IL31 FLG DEFB4A
8 superficial mycosis 30.2 CLEC7A CLEC6A CLEC4E
9 ichthyosis 30.1 SPINK5 KRT17 KRT16 FLG
10 scabies 30.1 IL31 AADACL3
11 seborrheic dermatitis 30.0 SPINK5 FLG DEFB4A
12 candidiasis 30.0 DEFB4A CLEC7A CARD9
13 psoriasis 30.0 KRT17 KRT16 IL31 FLG DEFB4A
14 cutaneous candidiasis 29.9 CLEC7A CLEC6A CARD9
15 dermatitis, atopic 29.9 SPINK5 IL31 FLG DEFB4A
16 fungal infectious disease 29.8 DEFB4A CLEC7A CLEC6A CLEC4E CARD9
17 tinea barbae 29.8 SQLE SPINK5 FLG CARD9
18 pityriasis versicolor 29.7 SQLE CLEC7A CLEC6A CLEC4E
19 lichen planus 29.6 KRT16 FLG DSG3 DEFB4A
20 dermatitis 29.5 SPINK5 KRT16 IL31 FLG DEFB4A
21 skin disease 29.1 SPINK5 KRT17 KRT16 IL31 FLG DSG3
22 tinea imbricata 11.2
23 tinea favosa 11.2
24 dermatomycosis 10.5
25 exanthem 10.3
26 tinea unguium 10.3
27 median rhomboid glossitis 10.3 KRT17 KRT16
28 glossitis 10.3 KRT17 KRT16
29 pachyonychia congenita 2 10.3 KRT17 KRT16
30 focal palmoplantar keratoderma 10.3 KRT17 KRT16
31 cutaneous lupus erythematosus 10.3
32 pustulosis of palm and sole 10.3
33 impetigo 10.3
34 herpes zoster 10.3
35 alopecia 10.3
36 subacute cutaneous lupus erythematosus 10.3
37 palmoplantar keratoderma, nonepidermolytic 10.2 KRT17 KRT16
38 palmoplantar keratoderma, nonepidermolytic, focal or diffuse 10.2 KRT17 KRT16
39 eccrine papillary adenoma 10.2 KRT17 KRT16
40 borst-jadassohn intraepidermal carcinoma 10.2 KRT17 KRT16
41 common wart 10.2 CLEC6A CLEC4E
42 immune deficiency disease 10.2
43 mycosis fungoides 10.2
44 spongiotic dermatitis 10.2
45 neurodermatitis 10.2 IL31 FLG
46 steatocystoma multiplex 10.1 KRT17 KRT16
47 epidermolysis bullosa pruriginosa 10.1 IL31 FLG
48 leukoplakia 10.1 FLG DEFB4A
49 psoriasis 15 10.1 IL31 DEFB4A
50 cholesteatoma of middle ear 10.1 KRT16 FLG DEFB4A

Graphical network of the top 20 diseases related to Tinea Corporis:



Diseases related to Tinea Corporis
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Symptoms & Phenotypes for Tinea Corporis

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Symptoms:

12
  • • itching
  • • red colored skin rash

GenomeRNAi Phenotypes related to Tinea Corporis according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-101 9.72 CLEC7A
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-103 9.72 CLEC7A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-123 9.72 CLEC4D
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.72 CLEC7A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.72 CLEC4D
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.72 CLEC7A
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.72 KRT17
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.72 CLEC7A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.72 CLEC7A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-151 9.72 CLEC4D
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-163 9.72 CLEC4D
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-164 9.72 CLEC7A
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-166 9.72 KRT17
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.72 CLEC4D
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-194 9.72 CLEC4D
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-202 9.72 CLEC7A
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-205 9.72 CLEC7A
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.72 CLEC7A
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.72 CLEC7A
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-46 9.72 CLEC4D
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.72 CLEC4D
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.72 CLEC4D
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.72 CLEC7A
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.72 CLEC7A
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-9 9.72 CLEC7A
Sources

Drugs & Therapeutics for Tinea Corporis

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Drugs for Tinea Corporis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Luliconazole Approved Phase 4 187164-19-8
4
Naftifine Approved Phase 4 65472-88-0 73342 47641
5 Antifungal Agents Phase 4
6 Anti-Infective Agents Phase 4
7 Dermatologic Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized, Multi-Center, Double-Blind, Vehicle-Controlled Study Evaluating the Safety and Efficacy of Product 33525 in Pediatric Subjects With Tinea Corporis Completed NCT02767947 Phase 4 Luliconazole Cream 1%;Vehicle Cream
2 An Open-Label, Multi-Center, Multiple-Application Pharmacokinetic Study of Naftin® (Naftifine Hydrochloride) Cream, 2% in Pediatric Subjects With Tinea Corporis Completed NCT02466867 Phase 4 Naftin® Cream, 2% (younger pediatric cohort);Naftin® Cream, 2% (older pediatric cohort)
3 A Phase 4, Double-Blind, Randomized, Vehicle-Controlled, Multicenter, Parallel Group Evaluation of the Efficacy and Safety of Naftin (Naftifine Hydrochloride) Cream, 2% in Pediatric Subjects With Tinea Corporis Completed NCT02227290 Phase 4 Naftin Cream;Placebo Cream
4 An Open-Label Study to Evaluate the Safety of Long-Term Administration of Product 33525 in Subjects With Tinea Pedis, Tinea Corporis, or Tinea Cruris Completed NCT01349998 Phase 3 Product 33525
5 Evaluation of Preclinical Toxicity of a Siddha Formulation Kandhaga Rasayanam ( KR ) and Its Therapeutic Efficacy in Padarthamarai ( Dermatophytoses ) by an Open Clinical Trial Completed NCT02238912 Phase 2 kandhaga rasayanam
6 Tele-dermatology of Skin Cancer: a Randomized Trial Comparing Remote Assessment With Conventional Visits in a Cohort of Local Health Authority Employees in the Province of Bergamo (the Shoot the Mole Study) Completed NCT02902822

Search NIH Clinical Center for Tinea Corporis

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Genetic Tests for Tinea Corporis

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Anatomical Context for Tinea Corporis

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The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Corporis:

19
Skin

MalaCards organs/tissues related to Tinea Corporis:

40
Skin, Bone Marrow, Bone, Thyroid, Breast
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Publications for Tinea Corporis

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Articles related to Tinea Corporis:

(show top 50) (show all 810)
# Title Authors PMID Year
1
Epidemiological study of terbinafine-resistant dermatophytes isolated from Japanese patients. 61
33439506 2021
2
Extensive tinea corporis caused by a virulent strain of Trichophyton interdigitale. 61
33599991 2021
3
Virulence and Antifungal Susceptibility of Microsporum canis Strains from Animals and Humans. 61
33809233 2021
4
Familial Cases of Trichophyton benhamiae Infection Transmitted from a Guinea Pig in Iran. 61
33394270 2021
5
Tinea corporis incognito due to Microsporum Gypseum: Report of eight cases in children. 61
33709430 2021
6
Letter in response to the article: "Nannizzia incurvata as a rare cause of favus and tinea corporis in Cambodia and Vietnam". 61
33666029 2021
7
The unprecedented epidemic-like scenario of dermatophytosis in India: I. Epidemiology, risk factors and clinical features. 61
33769736 2021
8
Nanoencapsulated hypericin in P-123 associated with photodynamic therapy for the treatment of dermatophytosis. 61
33383558 2021
9
[Report of the first case of tinea corporis bullosa by Trichophyton tonsurans]. 61
32820362 2021
10
Screening Balanites aegyptiaca for inhibitors against putative drug targets in Microsporum gypseum - Subtractive proteome, docking and simulation approach. 61
33549764 2021
11
A Case of Tinea Faciei, Tinea Corporis, and Tinea Unguium with Dermatophytoma Successfully Treated with Oral Fosravuconazole L-lysine Ethanolate. 61
33642522 2021
12
Treatment-resistant tinea corporis, a potential public health issue. 61
33428216 2021
13
Targetoid bullous tinea corporis: Unusual presentation of a dermatophyte infection. 61
33063704 2021
14
Tinea corporis by Nannizia gypsea: delayed diagnosis due to unusual presentation. 61
33281009 2021
15
Epidemiological Characterization of Dermatomycosis in Ethiopia. 61
33519223 2021
16
Analysis on the pathogenic fungi in patients with superficial mycosis in the Northeastern China during 10 years. 61
33209125 2020
17
Trichophyton indotineae sp. nov.: A New Highly Terbinafine-Resistant Anthropophilic Dermatophyte Species. 61
32449054 2020
18
Evaluation of efficacy and safety of oral terbinafine and itraconazole combination therapy in the management of dermatophytosis. 61
31030594 2020
19
Case Report: Extensive Tinea Corporis and Inflammatory Tinea Capitis Caused by the Anthropophilic Dermatophyte Trichophyton tonsurans. 61
32901593 2020
20
Topographic Differential Diagnosis of Chronic Plaque Psoriasis: Challenges and Tricks. 61
33171581 2020
21
Limited effectiveness of four oral antifungal drugs (fluconazole, griseofulvin, itraconazole and terbinafine) in the current epidemic of altered dermatophytosis in India: results of a randomized pragmatic trial. 61
32538466 2020
22
AI-based detection of erythema migrans and disambiguation against other skin lesions. 61
32949845 2020
23
[Tinea corporis within recent tattoos]. 61
32654791 2020
24
A mycological study of tinea corporis: A changing epidemiological trend from Trichophyton rubrum to Trichophyton mentagrophytes in India. 61
32068195 2020
25
Tinea corporis caused by Trichophyton equinum transmitted from asymptomatic dogs to two siblings. 61
31820297 2020
26
A comment on "First report of tinea corporis caused by Arthroderma benhamiae in Brazil". 61
31898250 2020
27
Congenital ichthyosis associated with Trichophyton rubrum tinea, imitating drug hypersensitivity reaction. 61
32547912 2020
28
[Microsporum ferrugineum-an anthropophilic dermatophyte in Germany : Case report and review of the literature]. 61
32394081 2020
29
Senna (Cassia) alata (Linn.) Roxb. leaf decoction as a treatment for tinea imbricata in an indigenous tribe in Southern Philippines. 61
32779266 2020
30
Atypical extensive tinea corporis caused by Trichophyton tonsurans. 61
32497801 2020
31
Dermatophytes and Dermatophytosis in Cluj-Napoca, Romania-A 4-Year Cross-Sectional Study. 61
32872110 2020
32
A prospective study on patterns of topical steroids self-use in dermatophytoses and determinants predictive of cutaneous side effects. 61
32449316 2020
33
Indian Association of Dermatologists, Venereologists and Leprologists (IADVL) Task Force against Recalcitrant Tinea (ITART) Consensus on the Management of Glabrous Tinea (INTACT). 61
32832435 2020
34
Varicella and herpes zoster appearing over sites of tinea corporis, hitherto unreported examples of immunocompromised districts: a case series. 61
32072634 2020
35
Epidemiological survey of 42 403 dermatophytosis cases examined at Nagasaki University Hospital from 1966 to 2015. 61
32293052 2020
36
Nannizzia incurvata as a rare cause of favus and tinea corporis in Cambodia and Vietnam. 61
32525102 2020
37
Dermatoscopy of tinea corporis. 61
32034804 2020
38
Tinea Corporis Masquerading as a Diffuse Gyrate Erythema: Case Report and a Review of Annular Lesions Mimicking a Dermatophyte Skin Infection. 61
32760635 2020
39
Species distribution of the main aetiologic agents causing skin dermatophytosis in Colombian patients: A 23-year experience at a Mycological Reference Center. 61
32163641 2020
40
Molecular epidemiology of Tinea gladiatorum in contact sports in northern Iran. 61
32096252 2020
41
Involvement of Little Discussed Anatomical Locations in Superficial Dermatophytosis Sundry Observations and Musings. 61
32695707 2020
42
Psychosocial and Financial Impact of Disease among Patients of Dermatophytosis, a Questionnaire-Based Observational Study. 61
32695696 2020
43
Tinea Corporis-associated Erythroderma: Case Report and Review of Erythrodermic Patients with Chronic Dermatophyte Infection. 61
32391227 2020
44
Tinea Gladiatorum and Dermatophyte Contamination Among Wrestlers and in Wrestling Halls: A Systematic Review and Meta-analysis. 61
31773190 2020
45
Case of tinea corporis due to terbinafine-resistant Trichophyton interdigitale. 61
31994232 2020
46
Current Trends of Dermatophytosis in Eastern Odisha. 61
32792788 2020
47
A case of tinea corporis by Epidermophyton floccosum mimicking Herpes zoster. 61
32041938 2020
48
In Vitro and Ex Vivo Antibiofilm Activity of a Lipopeptide Biosurfactant Produced by the Entomopathogenic Beauveria bassiana Strain against Microsporum canis. 61
32050410 2020
49
Whole-genome resequencing of Trichophyton rubrum provides insights into population differentiation and drug resistance. 61
31538279 2020
50
Analysis of cases managed by dermatological service in the Chinese peacekeeping level 1+ medical treatment facility in Lebanon, 2018-2019. 61
32111673 2020
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Variations for Tinea Corporis

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Expression for Tinea Corporis

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Search GEO for disease gene expression data for Tinea Corporis.
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Pathways for Tinea Corporis

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Pathways related to Tinea Corporis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Keratinization 65
Show member pathways
 12.01 SPINK5 KRT17 KRT16 FLG DSG3
2
Tuberculosis 36
11.8 CLEC7A CLEC4E CARD9
3
CLEC7A (Dectin-1) signaling 65
Show member pathways
 11.77 CLEC7A CLEC6A CLEC4E CLEC4D CARD9
4
Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 65
Show member pathways
 11.54 CLEC6A CLEC4E CLEC4D
5
Staphylococcus aureus infection 36
11.42 KRT17 KRT16 DEFB4A
6
C-type lectin receptor signaling pathway 36
Show member pathways
 11.26 CLEC7A CLEC6A CLEC4E CLEC4D CARD9
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GO Terms for Tinea Corporis

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Cellular components related to Tinea Corporis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.96 FLG DSG3
2 intermediate filament GO:0005882 8.8 KRT17 KRT16 FLG

Biological processes related to Tinea Corporis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.73 IL31 CLEC7A CLEC6A CLEC4E CLEC4D CARD9
2 innate immune response GO:0045087 9.63 KRT16 CLEC7A CLEC6A CLEC4E CLEC4D CARD9
3 keratinization GO:0031424 9.61 KRT17 KRT16 DSG3
4 establishment of skin barrier GO:0061436 9.4 KRT16 FLG
5 morphogenesis of an epithelium GO:0002009 9.37 KRT17 KRT16
6 positive regulation of stress-activated MAPK cascade GO:0032874 9.32 CLEC7A CARD9
7 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 CLEC6A CLEC4E CLEC4D CARD9
8 cornification GO:0070268 9.02 SPINK5 KRT17 KRT16 FLG DSG3

Molecular functions related to Tinea Corporis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.33 KRT17 KRT16 FLG
2 pattern recognition receptor activity GO:0038187 8.96 CLEC7A CLEC4E
3 carbohydrate binding GO:0030246 8.92 CLEC7A CLEC6A CLEC4E CLEC4D
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Sources for Tinea Corporis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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