MCID: TNC001
MIFTS: 36

Tinea Cruris

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Tinea Cruris

MalaCards integrated aliases for Tinea Cruris:

Name: Tinea Cruris 12 15 71 32
Dermatophytosis of Groin and Perianal Area 12
Dermatophytosis of Groin & Perianal Area 12
Tinea of Perianal Region 71
Dhobie Itch 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11917
ICD9CM 34 110.3
NCIt 49 C34535
ICD10 32 B35.6
UMLS 71 C0011638 C0040253 C1384589

Summaries for Tinea Cruris

Disease Ontology : 12 A dermatophytosis that results in fungal skin infection located in groin, located in perineum, or located in perianal region, has material basis in Ascomycota fungi that belong to a group called dermatophytes and has symptom itching in groin, thigh skin folds, or anus and results in formation of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

MalaCards based summary : Tinea Cruris, also known as dermatophytosis of groin and perianal area, is related to dermatomycosis and tinea manuum, and has symptoms including itching in groin An important gene associated with Tinea Cruris is SQLE (Squalene Epoxidase). The drugs Naftifine and Luliconazole have been mentioned in the context of this disorder. Affiliated tissues include groin, perineum and perianal region, and related phenotype is immune system.

Wikipedia : 74 Tinea cruris is a dermatophyte, a type of fungal infection of the groin region in either sex, though... more...

Related Diseases for Tinea Cruris

Diseases related to Tinea Cruris via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 dermatomycosis 31.0 CYP51A1 CBSL B4GALNT2
2 tinea manuum 30.7 CBSL B4GALNT2
3 candidiasis 30.4 DEFB4A CYP51A1 CARD9
4 pityriasis versicolor 30.4 SQLE CLEC6A CBSL
5 superficial mycosis 30.1 CLEC6A CBSL B4GALNT2
6 tinea unguium 30.0 SQLE FLNA CBSL B4GALNT2
7 tinea corporis 30.0 SQLE FLNA DEFB4A CLEC6A CBSL CARD9
8 dermatophytosis 29.9 SQLE FLNA DEFB4A CYP51A1 CLEC6A CBSL
9 fungal infectious disease 29.8 CYP51A1 CLEC6A CBSL CARD9 B4GALNT2
10 tinea pedis 29.7 SQLE DEFB4A CYP51A1 CLEC6A CBSL CARD9
11 tinea imbricata 10.5
12 contact dermatitis 10.5
13 allergic hypersensitivity disease 10.3
14 skin disease 10.3
15 esophageal candidiasis 10.3 CYP51A1 CARD9
16 white piedra 10.3 CBSL B4GALNT2
17 otomycosis 10.3 CBSL B4GALNT2
18 trichosporonosis 10.3 CBSL B4GALNT2
19 otitis externa 10.3 CBSL B4GALNT2
20 external ear disease 10.3 CBSL B4GALNT2
21 marginal corneal ulcer 10.2 FLNA DEFB4A
22 blastomycosis 10.2 CLEC6A CARD9
23 tinea profunda 10.2 CLEC6A CARD9
24 synovium neoplasm 10.2 KRT7 FLNA
25 sporotrichosis 10.2 CBSL CARD9
26 mucormycosis 10.2 CYP51A1 CARD9 B4GALNT2
27 corneal ulcer 10.2 CLEC6A B4GALNT2
28 blue rubber bleb nevus 10.2
29 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
30 extrapulmonary tuberculosis 10.2
31 dermatitis 10.2
32 irritant dermatitis 10.2
33 granuloma annulare 10.2
34 erythrasma 10.2
35 systemic scleroderma 10.2
36 tinea favosa 10.2
37 pustulosis of palm and sole 10.2
38 localized scleroderma 10.2
39 lupus erythematosus 10.2
40 psoriasis 10.2
41 tinea nigra 10.2
42 eczema herpeticum 10.2
43 candida glabrata 10.2
44 pityriasis rotunda 10.2
45 pustular psoriasis 10.2
46 cervicitis 10.1 FLNA DEFB4A
47 breast osteosarcoma 10.1 KRT7 FLNA
48 eumycotic mycetoma 10.1 CYP51A1 CBSL B4GALNT2
49 antley-bixler syndrome 10.1 SQLE CYP51A1
50 vaginal disease 10.1 DEFB4A CARD9

Graphical network of the top 20 diseases related to Tinea Cruris:



Diseases related to Tinea Cruris

Symptoms & Phenotypes for Tinea Cruris

Symptoms:

12
  • itching in groin

MGI Mouse Phenotypes related to Tinea Cruris:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.23 B4GALNT2 CARD9 CBSL CLEC6A CYP51A1 FLNA

Drugs & Therapeutics for Tinea Cruris

Drugs for Tinea Cruris (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Naftifine Approved Phase 4 65472-88-0 47641 73342
2
Luliconazole Approved Phase 4 187164-19-8
3
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
4
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
5
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
6
Itraconazole Approved, Investigational Phase 4 84625-61-6 55283
7 Antacids Phase 4
8 Anti-Ulcer Agents Phase 4
9 Gastrointestinal Agents Phase 4
10 Proton Pump Inhibitors Phase 4
11 Antifungal Agents Phase 4
12 Anti-Infective Agents Phase 4
13 Cytochrome P-450 Enzyme Inhibitors Phase 4
14 Hormone Antagonists Phase 4
15 Hormones Phase 4
16 Cytochrome P-450 CYP3A Inhibitors Phase 4
17
Hydroxyitraconazole Phase 4
18 Anti-Infective Agents, Local Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 An Open-Label Study to Assess the Pharmacokinetics With Maximal Use of Luliconazole Cream 1% in Pediatric Patients With Moderate to Severe Tinea Pedis or Tinea Cruris Completed NCT02767271 Phase 4 Luliconazole Cream 1%
2 An Open-Label, Multi-Center, Multiple-Application Pharmacokinetic Study of NAFT-500 in Pediatric Subjects With Tinea Cruris and Tinea Pedis and NAFT-600 in Pediatric Subjects With Tinea Pedis Completed NCT01712360 Phase 4 NAFT500 (pediatric);NAFT600 (pediatric);NAFT500 (adult);NAFT600 (adult)
3 An Open-Label, Maximal Use Study Evaluating the Drug Interaction Potential of Luliconazole Cream 1% in Subjects With Tinea Pedis and Tinea Cruris Completed NCT02394340 Phase 4 Omeprazole 40 mg;Luliconazole Cream 1%
4 Itraconazole in the Management of Superficial Fungal Infections in India. A Pilot Study Recruiting NCT03923010 Phase 4 Itraconazole
5 A Randomized, Multi-Center, Double-Blind, Vehicle-Controlled Study Evaluating the Efficacy and Safety of Product 33525 in Subjects With Tinea Cruris Completed NCT01342315 Phase 3 33525;Placebo
6 A Phase 3 Double-Blind, Randomized, Placebo-Controlled,Multicenter, Parallel Group Evaluation of the Efficacy and Safety of NAFT-500 in Subjects With Tinea Cruris Completed NCT00750152 Phase 3 NAFT-500;Placebo
7 An Open-Label Study to Evaluate the Safety of Long-Term Administration of Product 33525 in Subjects With Tinea Pedis, Tinea Corporis, or Tinea Cruris Completed NCT01349998 Phase 3 Product 33525
8 A Phase 3 Double-Blind, Randomized, Placebo-Controlled, Multicenter, Parallel Group Evaluation of the Efficacy and Safety of Naftin 1% Cream in Adolescent Subjects With Tinea Cruris Completed NCT01885156 Phase 3 Naftin 1% Cream;Placebo Cream
9 Clinical Study of Non-inferiority (Phase 2), Comparing Dapaconazole (BL123 - Biolab Sanus Farmacêutica Ltda.) Versus Miconazole Nitrate (União Química) in Patients With a Single Lesion of Tinea Cruris. Completed NCT03359070 Phase 2 Dapaconazole;Miconazole Nitrate
10 Evaluation of Preclinical Toxicity of a Siddha Formulation Kandhaga Rasayanam ( KR ) and Its Therapeutic Efficacy in Padarthamarai ( Dermatophytoses ) by an Open Clinical Trial Completed NCT02238912 Phase 2 kandhaga rasayanam

Search NIH Clinical Center for Tinea Cruris

Genetic Tests for Tinea Cruris

Anatomical Context for Tinea Cruris

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Cruris:

19
Groin, Perineum, Perianal Region

MalaCards organs/tissues related to Tinea Cruris:

40
Skin, Testes

Publications for Tinea Cruris

Articles related to Tinea Cruris:

(show top 50) (show all 373)
# Title Authors PMID Year
1
Limited effectiveness of four oral antifungal drugs (fluconazole, griseofulvin, itraconazole and terbinafine) in the current epidemic of altered dermatophytosis in India: results of a randomized pragmatic trial. 61
32538466 2020
2
Photodynamic therapy treatment of superficial fungal infections: a systematic review. 61
32339671 2020
3
Skin Infections and Outpatient Burn Management: Fungal and Viral Skin Infections. 61
31995350 2020
4
Prevalence and clinical characteristics of itch in epidemic-like scenario of dermatophytoses in India: a cross-sectional study. 61
31419346 2020
5
A unique multidrug-resistant clonal Trichophyton population distinct from Trichophyton mentagrophytes/Trichophyton interdigitale complex causing an ongoing alarming dermatophytosis outbreak in India: Genomic insights and resistance profile. 61
31491507 2019
6
Trichophyton mentagrophytes and T interdigitale genotypes are associated with particular geographic areas and clinical manifestations. 61
31444823 2019
7
Can Dermoscopy Serve as a Diagnostic Tool in Dermatophytosis? A Pilot Study. 61
31544071 2019
8
A Cross-Sectional Study on the Dermatoses in Postmenopausal Patients at a Rural-Based Tertiary Health Care Center. 61
31543529 2019
9
Epidemiology of dermatophytosis in northeastern Iran; A subtropical region. 61
31321333 2019
10
A randomized, double-blind trial of amorolfine 0.25% cream and sertaconazole 2% cream in limited dermatophytosis. 61
30409926 2019
11
Dermatophytoses and spectrum of dermatophytes in patients attending a teaching hospital in Western Rajasthan, India. 61
31143732 2019
12
Risk factors for chronic and chronic-relapsing tinea corporis, tinea cruris and tinea faciei: Results of a case-control study. 61
30719987 2019
13
Efficacy of oral terbinafine versus itraconazole in treatment of dermatophytic infection of skin - A prospective, randomized comparative study. 61
31142947 2019
14
2016 Epidemiological Survey of Dermatomycoses in Japan. 61
31474694 2019
15
Comparison of dapaconazole with miconazole in the treatment of Tinea cruris. 61
29888509 2019
16
Dermatophytes in Skin, Nail and Hair among the Patients Attending Out Patient Department. 61
30739936 2019
17
Primary extramammary Paget's disease: a clinicopathological study of 28 cases. 61
31934186 2019
18
Potassium hydroxide mount with cellophane adhesive tape: a method for direct diagnosis of dermatophyte skin infections. 61
29845649 2018
19
MiR-155, a potential serum marker of extramammary Paget's disease. 61
30458743 2018
20
End of the road for terbinafine? Results of a pragmatic prospective cohort study of 500 patients. 61
29893296 2018
21
A case of granuloma annulare mimicking tinea cruris. 61
30677851 2018
22
Study of prevalence of dermatophytes among human immunodeficiency virus/AIDS patients in Shadan Institute of Medical Sciences and Teaching Hospital and Research Centre, Hyderabad, Telangana, India. 61
30623179 2018
23
Expert Consensus on The Management of Dermatophytosis in India (ECTODERM India). 61
30041646 2018
24
Epidemiology of dermatophytoses in 31 municipalities of the province of Buenos Aires, Argentina: A 6-year study. 61
29606407 2018
25
Characterizing the clinical isolates of dermatophytes in Hamadan city, Central west of Iran, using PCR-RLFP method. 61
29439839 2018
26
Cryptococcosis as a cause of nephrotic syndrome? A case report and review of the literature. 61
29942774 2018
27
Current Trends of Using Systemic Antifungal Drugs and their Comparative Efficacy in Tinea Corporis and Tinea Cruris in Outpatient Department of Dermatology in a Tertiary Level Hospital. 61
29459592 2018
28
A Comparative Study of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism and Fungal Culture for the Evaluation of Fungal Species in Patients with Tinea Cruris. 61
29362607 2017
29
Tavaborole, Efinaconazole, and Luliconazole: Three New Antimycotic Agents for the Treatment of Dermatophytic Fungi. 61
27488125 2017
30
Incidence and biodiversity of yeasts, dermatophytes and non-dermatophytes in superficial skin infections in Assiut, Egypt. 61
28188051 2017
31
Analysis on curative effects and safety of 2% liranaftate ointment in treating tinea pedis and tinea corporis & cruris. 61
28671089 2017
32
Epidemiological status of dermatophytosis in Guilan, north of Iran. 61
29302626 2017
33
New Antifungal Agents and New Formulations Against Dermatophytes. 61
27502503 2017
34
[Clinical problems in medical mycology: Problem number 50]. 61
27450641 2017
35
Characterization of clinically important dermatophytes in North of Iran using PCR-RFLP on ITS region. 61
27496524 2016
36
Epidemiological trends of dermatophytosis in Tehran, Iran: A five-year retrospective study. 61
27520535 2016
37
Efficacy and tolerability of topical sertaconazole versus topical terbinafine in localized dermatophytosis: A randomized, observer-blind, parallel group study. 61
28066103 2016
38
Risk-Factors and Awareness of HPV in Turkish people with Anogenital Warts in Bagcilar district: a Cross-Sectional Study. 61
27743437 2016
39
Male genital dermatophytosis - clinical features and the effects of the misuse of topical steroids and steroid combinations - an alarming problem in India. 61
27028087 2016
40
Relapse after Oral Terbinafine Therapy in Dermatophytosis: A Clinical and Mycological Study. 61
27688443 2016
41
Epidemiological Aspects of Dermatophytosis in Khuzestan, southwestern Iran, an Update. 61
26886443 2016
42
Isolation, Identification, and In Vitro Antifungal Susceptibility Testing of Dermatophytes from Clinical Samples at Sohag University Hospital in Egypt. 61
27504173 2016
43
Epidemiology of Superficial Fungal Infections in Guangdong, Southern China: A Retrospective Study from 2004 to 2014. 61
26883512 2016
44
Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review. 61
27057486 2016
45
Molecular Characterization and In Vitro Antifungal Susceptibility of 316 Clinical Isolates of Dermatophytes in Iran. 61
26369643 2016
46
Computational analysis of conserved coil functional residues in the mitochondrial genomic sequences of dermatophytes. 61
28149055 2016
47
A critical appraisal of once-daily topical luliconazole for the treatment of superficial fungal infections. 61
26848272 2016
48
Griseofulvin and/or Terbinafine Induced Toxic Epidermal Necrolysis in an Adult Female Patient - A Case Report. 61
26695069 2016
49
Epidemiology of Dermatophytoses in Crete, Greece. 61
27904054 2016
50
Oral Antifungal Drugs in the Treatment of Dermatomycosis. 61
27251319 2016

Variations for Tinea Cruris

Expression for Tinea Cruris

Search GEO for disease gene expression data for Tinea Cruris.

Pathways for Tinea Cruris

GO Terms for Tinea Cruris

Cellular components related to Tinea Cruris according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 organelle membrane GO:0031090 8.8 SQLE CYP51A1 CYP2A6

Biological processes related to Tinea Cruris according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol biosynthetic process GO:0006695 9.32 SQLE CYP51A1
2 negative regulation of protein catabolic process GO:0042177 9.26 FLNA CYP51A1
3 regulation of cholesterol biosynthetic process GO:0045540 9.16 SQLE CYP51A1
4 sterol biosynthetic process GO:0016126 8.96 SQLE CYP51A1
5 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 8.8 FLNA CLEC6A CARD9

Molecular functions related to Tinea Cruris according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.8 CYP51A1 CYP2A6 CBSL

Sources for Tinea Cruris

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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