MCID: TNC001
MIFTS: 33

Tinea Cruris

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Tinea Cruris

MalaCards integrated aliases for Tinea Cruris:

Name: Tinea Cruris 12 15 73
Dermatophytosis of Groin and Perianal Area 12
Dermatophytosis of Groin & Perianal Area 12
Tinea of Perianal Region 73
Dhobie Itch 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11917
ICD9CM 35 110.3
NCIt 50 C34535
SNOMED-CT 68 59089002
ICD10 33 B35.6

Summaries for Tinea Cruris

Disease Ontology : 12 A dermatophytosis that results in fungal skin infection located in groin, located in perineum, or located in perianal region, has material basis in Ascomycota fungi that belong to a group called dermatophytes and has symptom itching in groin, thigh skin folds, or anus and results in_formation_of rash which appears as raised red plaques (platelike areas) and scaly patches with sharply defined borders that may blister and ooze.

MalaCards based summary : Tinea Cruris, also known as dermatophytosis of groin and perianal area, is related to tinea corporis and dermatophytosis, and has symptoms including itching in groin An important gene associated with Tinea Cruris is SQLE (Squalene Epoxidase). The drugs Omeprazole and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, groin and perineum, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Wikipedia : 76 Tinea cruris or eczema marginatum (also known colloquially as crotch itch, crotch rot, Dhobi itch, gym... more...

Related Diseases for Tinea Cruris

Diseases related to Tinea Cruris via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 tinea corporis 31.3 DEFB4A SQLE
2 dermatophytosis 30.3 DEFB4A SQLE
3 tinea pedis 10.7
4 tinea imbricata 10.3
5 pityriasis versicolor 10.3
6 skin disease 10.1
7 tinea manuum 10.1
8 candidiasis 10.1
9 erythrasma 10.1
10 human immunodeficiency virus infectious disease 10.1
11 localized scleroderma 10.1
12 tinea nigra 10.1
13 eczema herpeticum 10.1
14 pityriasis rotunda 10.1
15 tinea unguium 9.7 CBS PPIG

Graphical network of the top 20 diseases related to Tinea Cruris:



Diseases related to Tinea Cruris

Symptoms & Phenotypes for Tinea Cruris

Symptoms:

12
  • itching in groin

GenomeRNAi Phenotypes related to Tinea Cruris according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-110 9.4 GTF2IRD1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.4 CBS
3 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.4 GTF2IRD1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-194 9.4 GTF2IRD1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.4 CBS
6 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.4 CBS
7 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.4 CBS
8 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.4 CBS
9 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.4 GTF2IRD1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.4 CBS GTF2IRD1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.4 CBS

Drugs & Therapeutics for Tinea Cruris

Drugs for Tinea Cruris (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
3
Naftifine Approved Phase 4,Phase 3 65472-88-0 47641 73342
4 Anti-Ulcer Agents Phase 4
5 Gastrointestinal Agents Phase 4
6 Antacids Phase 4
7 Proton Pump Inhibitors Phase 4
8 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
10
Tolnaftate Approved, Investigational, Vet_approved Phase 3 2398-96-1 5510
11
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
12 Hormones Phase 2,Phase 1,Not Applicable
13 Steroid Synthesis Inhibitors Phase 2,Phase 1,Not Applicable
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Phase 1,Not Applicable
15 Hormone Antagonists Phase 2,Phase 1,Not Applicable
16 Cytochrome P-450 CYP3A Inhibitors Phase 2,Phase 1,Not Applicable
17 Cytochrome P-450 CYP2C9 Inhibitors Phase 2,Phase 1,Not Applicable
18 Cytochrome P-450 Enzyme Inhibitors Phase 2,Phase 1,Not Applicable
19
Bradykinin Investigational Phase 1 58-82-2 439201
20 omega-N-Methylarginine Phase 1
21 Kininogens Phase 1
22 Vasodilator Agents Phase 1

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Study Evaluating the Drug Interaction Potential of Luliconazole Cream 1% in Subjects With Tinea Pedis and Tinea Cruris Unknown status NCT02394340 Phase 4 Omeprazole 40mg
2 Maximal Use of Luliconazole Cream 1% in Pediatric Patients With Moderate to Severe Tinea Pedis or Tinea Cruris Completed NCT02767271 Phase 4 Luliconazole Cream 1%
3 Pharmacokinetic Study of Pediatric Subjects With Tinea Cruris and Tinea Pedis Completed NCT01712360 Phase 4 NAFT500 (pediatric);NAFT600 (pediatric);NAFT500 (adult);NAFT600 (adult)
4 Evaluate the Efficacy and Safety of Tolnaftate Cream in the Treatment of Patients With Fungal Infections Unknown status NCT01105013 Phase 3 Clotrimazole
5 Topical Antifungal Treatment for Tinea Cruris Completed NCT01342315 Phase 3 33525;Placebo
6 Multicenter Study of the Safety and Efficacy of NAFT-500 in Tinea Cruris Completed NCT00750152 Phase 3 NAFT-500;Placebo
7 Evaluation of Efficacy and Safety of Naftin 1% Cream in Adolescent Subjects With Tinea Cruris Completed NCT01885156 Phase 3 Naftin 1% Cream;Placebo Cream
8 Safety of a Topical Antifungal Treatment for Tinea Cruris, Tinea Pedis and Tinea Corporis Completed NCT01349998 Phase 3 Product 33525
9 Clinical Trial Comparing Dapaconazole Versus Miconazole in Patients With Tinea Cruris Completed NCT03359070 Phase 2 Dapaconazole;Miconazole Nitrate
10 Evaluation of Preclinical Toxicity andTherapeutic Efficacy of Kandhaga Rasayanam in Padarthamarai Completed NCT02238912 Phase 2 kandhaga rasayanam
11 Effects of Miconazole on Blood Flow Completed NCT00004575 Phase 1 Miconazole, L-NMMA, Bradykinin
12 Clinical Case Series Evaluating Skin Wellness System Completed NCT01724229 Not Applicable Kendall Body Wash & Shampoo; Moisture Barrier Cream; 2-in-1 Cleanser; Antifungal Cream

Search NIH Clinical Center for Tinea Cruris

Genetic Tests for Tinea Cruris

Anatomical Context for Tinea Cruris

MalaCards organs/tissues related to Tinea Cruris:

41
Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Cruris:

19
Groin, Perineum, Perianal Region

Publications for Tinea Cruris

Articles related to Tinea Cruris:

(show top 50) (show all 113)
# Title Authors Year
1
Comparison of dapaconazole with miconazole in the treatment of Tinea cruris. ( 29888509 )
2018
2
Current Trends of Using Systemic Antifungal Drugs and their Comparative Efficacy in Tinea Corporis and Tinea Cruris in Outpatient Department of Dermatology in a Tertiary Level Hospital. ( 29459592 )
2018
3
A Comparative Study of Polymerase Chain Reaction-Restriction Fragment Length Polymorphism and Fungal Culture for the Evaluation of Fungal Species in Patients with<i>Tinea Cruris</i>. ( 29362607 )
2017
4
Management of tinea corporis, tinea cruris, and tinea pedis: A comprehensive review. ( 27057486 )
2016
5
Tinea cruris and tinea corporis masquerading as tinea indecisiva: case report and review of the literature. ( 25775632 )
2015
6
A randomized, multicenter, double-blind, vehicle-controlled study evaluating the efficacy and safety of luliconazole cream 1% once daily for 7 days in patients aged a8Y 12 years with tinea cruris. ( 24385117 )
2014
7
Efficacy and safety of terbinafine hydrochloride 1% cream vs eberconazole nitrate 1% cream in localised tinea corporis and tinea cruris. ( 24860743 )
2014
8
Evidence based topical treatments for tinea cruris and tinea corporis: A summary of a Cochrane systematic review. ( 25294700 )
2014
9
Topical antifungal treatments for tinea cruris and tinea corporis. ( 25090020 )
2014
10
Tinea cruris and tinea corporis masquerading as tinea indecisiva: case report and review of the literature. ( 25277164 )
2014
11
A case of tinea cruris of the amputation stump: an example of an immunocompromised district. ( 25266670 )
2014
12
A case of localized scleroderma mimicking tinea cruris. ( 24153152 )
2013
13
An unusual presentation of tinea cruris with bullous lesions. ( 23815953 )
2013
14
Efficacy and Safety of Terbinafine Hydrochloride 1% Cream vs. Sertaconazole Nitrate 2% Cream in Tinea Corporis and Tinea Cruris: A Comparative Therapeutic Trial. ( 24249898 )
2013
15
A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris. ( 21968664 )
2011
16
Intermittent pulse-dosed terbinafine in the treatment of tinea corporis and/or tinea cruris. ( 21572814 )
2011
17
Annular lupus vulgaris mimicking tinea cruris. ( 20548922 )
2010
18
Studies on comparison of the efficacy of terbinafine 1% cream and butenafine 1% cream for the treatment of Tinea cruris. ( 23130183 )
2010
19
Tinea cruris in children. ( 19842572 )
2009
20
5-Aminolevulininic acid photodynamic therapy treatment for tinea cruris caused by Trichophyton rubrum: report of 10 cases. ( 18637974 )
2009
21
The efficacy of oral treatment with pramiconazole in tinea pedis and tinea cruris/corporis: two exploratory phase IIa trials. ( 18241269 )
2008
22
Successful therapy of tinea cruris with topical isoconazole in combination with a corticosteroid. ( 18783561 )
2008
23
Tinea cruris treated with a combined topical therapy containing isoconazole and a corticosteroid. ( 18783563 )
2008
24
Unusual presentation of tinea cruris due to Trichophyton mentagrophytes var. mentagrophytes. ( 18789076 )
2008
25
What is the best way to treat tinea cruris? ( 16510062 )
2006
26
Comparative efficacy of topical 1% butenafine and 1% clotrimazole in tinea cruris and tinea corporis: a randomized, double-blind trial. ( 16428155 )
2005
27
Tinea cruris in routine urology practice. ( 15897702 )
2005
28
Importance of mycological confirmation of clinically suspected cases of tinea corporis, tinea pedis and tinea cruris. ( 16916049 )
2004
29
An alternative treatment for pityriasis versicolor, tinea cruris, tinea corporis and tinea faciei with topical application of honey, olive oil and beeswax mixture: an open pilot study. ( 15130571 )
2004
30
Eczema herpeticum localized to area of tinea cruris. ( 14739507 )
2004
31
Tinea corporis, tinea cruris, tinea nigra, and piedra. ( 12956194 )
2003
32
Randomised controlled trial of topical butenafine in tinea cruris and tinea corporis. ( 17642865 )
2003
33
Abbreviated oral itraconazole therapy for tinea corporis and tinea cruris. ( 12950901 )
2003
34
Tinea cruris in female prostitutes. ( 11913763 )
2002
35
Tinea cruris due to combined infections of Trichophyton mentagrophytes and Microsporum canis. A case report. ( 11800157 )
2001
36
Pityriasis rotunda mimicking tinea cruris/corporis and erythrasma in an Indian patient. ( 11280467 )
2001
37
Efficacy and safety of butenafine in superficial dermatophytoses (tinea pedis, tinea cruris, tinea corporis). ( 11676116 )
2001
38
Efficacy and safety of terbinafine 1% solution in the treatment of interdigital tinea pedis and tinea corporis or tinea cruris. ( 11270304 )
2001
39
Safety and efficacy of short-duration oral terbinafine for the treatment of tinea corporis or tinea cruris in subjects with HIV infection or diabetes. ( 11499330 )
2001
40
Tinea cruris epidemiology (SALo Paulo, Brazil). ( 11307598 )
2001
41
Personal hygiene as an alternative to griseofulvin in the treatment of tinea cruris. ( 11379466 )
2000
42
Comparative study between terbinafine 1% emulsion-gel versus ketoconazole 2% cream in tinea cruris and tinea corporis. ( 10694308 )
2000
43
The frequency of tinea pedis in patients with tinea cruris in Tehran, Iran. ( 10838845 )
2000
44
Ajoene in the topical short-term treatment of tinea cruris and tinea corporis in humans. Randomized comparative study with terbinafine. ( 10417874 )
1999
45
A comparison of the efficacy of oral fluconazole, 150 mg/week versus 50 mg/day, in the treatment of tinea corporis, tinea cruris, tinea pedis, and cutaneous candidosis. ( 9762826 )
1998
46
Terbinafine 1% cream vs. bifonazole 1% cream in the treatment of tinea cruris. ( 9865880 )
1998
47
Fluconazole in the treatment of tinea corporis and tinea cruris. ( 9568414 )
1998
48
Itraconazole in the treatment of tinea corporis and tinea cruris: comparison of two treatment schedules. ( 9919895 )
1998
49
Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial. ( 9039201 )
1997
50
Open clinical study of the efficacy and safety of terbinafine cream 1% in children with tinea corporis and tinea cruris. ( 9194102 )
1997

Variations for Tinea Cruris

Expression for Tinea Cruris

Search GEO for disease gene expression data for Tinea Cruris.

Pathways for Tinea Cruris

GO Terms for Tinea Cruris

Sources for Tinea Cruris

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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