MCID: TNF001
MIFTS: 35

Tinea Favosa

Categories: Infectious diseases

Aliases & Classifications for Tinea Favosa

MalaCards integrated aliases for Tinea Favosa:

Name: Tinea Favosa 12 44 15 73
Favus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4336
ICD10 33 B35
MeSH 44 D014007
NCIt 50 C35072
SNOMED-CT 68 85375000
UMLS 73 C0040254

Summaries for Tinea Favosa

Disease Ontology : 12 A tinea capitis that results in fungal infection located in scalp, located in glabrous skin or located in nail, has material basis in Ascomycota fungi that belong to a group called dermatophytes and results in_formation_of scutula, yellowish cup-shaped crusts of dense masses of mycelium and epithelial debris, which develop at the surface of a hair follicle with the shaft in the center of the raised lesion. Removal of these crusts reveals an oozing, moist, red base. Later, atrophy of the skin occurs leaving a cicatricial alopecia and scarring.

MalaCards based summary : Tinea Favosa, also known as favus, is related to choanal atresia, posterior and familial cold autoinflammatory syndrome 1. An important gene associated with Tinea Favosa is RDH11 (Retinol Dehydrogenase 11), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Immune response Fc epsilon RI pathway. The drugs Estradiol valerate and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include scalp, glabrous skin or and skin, and related phenotypes are cellular and digestive/alimentary

Related Diseases for Tinea Favosa

Diseases related to Tinea Favosa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 choanal atresia, posterior 10.3 CHD7 FOXE1
2 familial cold autoinflammatory syndrome 1 10.2 CASP1 NLRP3
3 chronic recurrent multifocal osteomyelitis 10.2 CASP1 NLRP3
4 tinea capitis 10.1
5 muckle-wells syndrome 10.1 CASP1 NLRP3
6 cinca syndrome 10.0 CASP1 NLRP3
7 familial cold autoinflammatory syndrome 10.0 CASP1 NLRP3
8 charge syndrome 10.0 CHD7 FOXE1
9 dermatophytosis 10.0
10 tinea cruris 9.8
11 coccidioidomycosis 9.8
12 histoplasmosis 9.8
13 lichen planus 9.8
14 mycetoma 9.8
15 familial mediterranean fever 9.6 CASP1 NLRP3
16 toxic myocarditis 9.6 MAPK8 NOS3
17 limb ischemia 9.2 KDR NOS3

Graphical network of the top 20 diseases related to Tinea Favosa:



Diseases related to Tinea Favosa

Symptoms & Phenotypes for Tinea Favosa

MGI Mouse Phenotypes related to Tinea Favosa:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.05 CHD7 MAPK8 CTSB CASP1 KDR NOS3
2 digestive/alimentary MP:0005381 10.04 MAPK8 CTSB CASP1 FOXE1 CHD7 NLRP3
3 homeostasis/metabolism MP:0005376 10.03 MAPK8 CTSB CASP1 FOXE1 KDR CHD7
4 growth/size/body region MP:0005378 10 CHD7 MAPK8 CTSB FOXE1 KDR NOS3
5 endocrine/exocrine gland MP:0005379 9.95 CHD7 MAPK8 CTSB FOXE1 CASP1 NOS3
6 immune system MP:0005387 9.95 MAPK8 CTSB CASP1 KDR CHD7 NLRP3
7 mortality/aging MP:0010768 9.92 MAPK8 CTSB CASP1 FOXE1 KDR CHD7
8 integument MP:0010771 9.85 MAPK8 CTSB CASP1 FOXE1 KDR NLRP3
9 nervous system MP:0003631 9.8 MAPK8 CTSB CASP1 KDR CHD7 NLRP3
10 renal/urinary system MP:0005367 9.55 MAPK8 CTSB CASP1 NOS3 NLRP3
11 reproductive system MP:0005389 9.43 MAPK8 CASP1 CHD7 RDH11 NLRP3 NOS3
12 vision/eye MP:0005391 9.02 CHD7 MAPK8 KDR NOS3 RDH11

Drugs & Therapeutics for Tinea Favosa

Drugs for Tinea Favosa (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Estradiol valerate Approved, Investigational, Vet_approved Phase 2 979-32-8
2
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
3
Polyestradiol phosphate Approved Phase 2 28014-46-2
4 Contraceptive Agents Phase 2
5 Hormone Antagonists Phase 2
6 Hormones Phase 2
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
8 Estradiol 17 beta-cypionate Phase 2
9 Estradiol 3-benzoate Phase 2
10 Estrogens Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Effects of Estrogen Replacement Therapy in Postmenopausal Women With Hypercalciuria and Low Bone Mass Terminated NCT01928082 Phase 2 Transdermal estradiol

Search NIH Clinical Center for Tinea Favosa

Cochrane evidence based reviews: tinea favosa

Genetic Tests for Tinea Favosa

Anatomical Context for Tinea Favosa

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Favosa:

19
Scalp, Glabrous Skin Or

MalaCards organs/tissues related to Tinea Favosa:

41
Skin, Bone

Publications for Tinea Favosa

Articles related to Tinea Favosa:

# Title Authors Year
1
Generalized Favus: The Story of a Legendary Case of Tinea Favosa. ( 25583289 )
2015
2
Goya and tinea favosa. ( 25387510 )
2014
3
Study of 73 cases of tinea capitis and tinea favosa in adults and adolescents. ( 5697378 )
1968
4
DEHYDROEMETINE IN FUNGUS INFECTION (TINEA FAVOSA). ( 14201655 )
1964
5
Treatment Op Tinea Favosa. ( 21379048 )
1843

Variations for Tinea Favosa

Expression for Tinea Favosa

Search GEO for disease gene expression data for Tinea Favosa.

Pathways for Tinea Favosa

Pathways related to Tinea Favosa according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.61 CASP1 CTSB MAPK8 NLRP3
2
Show member pathways
12.23 KDR MAPK8 NOS3
3
Show member pathways
12.07 KDR MAPK8 NOS3
4
Show member pathways
12.06 KDR MAPK8 NOS3
5
Show member pathways
11.8 KDR MAPK8 NOS3
6
Show member pathways
11.74 CASP1 MAPK8 NLRP3
7
Show member pathways
11.67 CASP1 MAPK8 NLRP3
8 11.47 KDR MAPK8 NOS3
9 11.11 CASP1 NLRP3
10
Show member pathways
11.05 KDR MAPK8 NOS3
11 10.91 CHD7 MAPK8
12 10.78 KDR NOS3
13 10.68 CASP1 MAPK8 NLRP3

GO Terms for Tinea Favosa

Cellular components related to Tinea Favosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NLRP3 inflammasome complex GO:0072559 8.62 CASP1 NLRP3

Biological processes related to Tinea Favosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to cytokine stimulus GO:0071345 9.46 CASP1 MAPK8
2 positive regulation of blood vessel endothelial cell migration GO:0043536 9.43 KDR NOS3
3 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.4 CASP1 NLRP3
4 cellular response to organic substance GO:0071310 9.37 CASP1 MAPK8
5 response to bacterium GO:0009617 9.32 CASP1 NLRP3
6 blood vessel remodeling GO:0001974 9.26 CHD7 NOS3
7 positive regulation of interleukin-1 beta secretion GO:0050718 9.16 CASP1 NLRP3
8 cellular response to lipopolysaccharide GO:0071222 9.13 CASP1 MAPK8 NLRP3
9 interleukin-1 beta production GO:0032611 8.62 CASP1 NLRP3

Molecular functions related to Tinea Favosa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cysteine-type endopeptidase activity GO:0004197 8.62 CASP1 CTSB

Sources for Tinea Favosa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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