MCID: TNM001
MIFTS: 39

Tinea Imbricata

Categories: Infectious diseases, Rare diseases, Skin diseases

Aliases & Classifications for Tinea Imbricata

MalaCards integrated aliases for Tinea Imbricata:

Name: Tinea Imbricata 57 12 15 71 32
Kerion Celsi 20 58
Tinea Imbricata, Susceptibility to 57
Susceptibility to Tinea Imbricata 20
Trichophytia Profunda Capitis 20
Trichophytia Profunda Barbae 20
Tinea Capitis Profunda 20
Trichophyton Infection 20

Characteristics:

Orphanet epidemiological data:

58
kerion celsi
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

OMIM®:

57 (Updated 05-Mar-2021)
Inheritance:
autosomal recessive


HPO:

31
tinea imbricata:
Inheritance autosomal recessive inheritance


Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

Disease Ontology 12 DOID:0050116
OMIM® 57 275240
ICD10 32 B35.5
MESH via Orphanet 45 C536165
ICD10 via Orphanet 33 B35.0
UMLS via Orphanet 72 C0276742
Orphanet 58 ORPHA499
MedGen 41 C0276742
UMLS 71 C0040255

Summaries for Tinea Imbricata

Disease Ontology : 12 A tinea corporis that results in fungal infection located in skin, has material basis in Trichophyton concentricum, which is characterized by ring-like growth in overlapping circles that may have an autosomal dominant genetic predisposition.

MalaCards based summary : Tinea Imbricata, also known as kerion celsi, is related to dermatophytosis and tinea capitis. An important gene associated with Tinea Imbricata is RPL10 (Ribosomal Protein L10), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Sennoside A&B and Senna have been mentioned in the context of this disorder. Affiliated tissues include skin and liver, and related phenotypes are recurrent cutaneous abscess formation and fever

Wikipedia : 74 Tinea imbricata (also known in parts of Indonesia as “Kaskado”) is a superficial fungal infection of the... more...

More information from OMIM: 275240

Related Diseases for Tinea Imbricata

Diseases related to Tinea Imbricata via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 dermatophytosis 11.0
2 tinea capitis 10.7
3 erythema nodosum 10.6
4 alopecia 10.6
5 superficial mycosis 10.4
6 tinea corporis 10.3
7 syphilis 10.3
8 panniculitis 10.3
9 tinea cruris 10.2
10 dermatomycosis 10.2
11 thrombocytopenic purpura, autoimmune 10.2
12 hypomelanosis of ito 10.2
13 tinea manuum 10.2
14 angioedema 10.2
15 purpura 10.2
16 immune deficiency disease 10.1
17 filariasis 10.1
18 allergic disease 10.1
19 blastomycosis 10.1
20 secondary syphilis 10.1
21 cardiomyopathy, dilated, with woolly hair and keratoderma 9.9 PKP3 DSG1
22 palmoplantar keratoderma, nonepidermolytic 9.9 PKP3 DSG1
23 respiratory allergy 9.9
24 rhinitis 9.9
25 scabies 9.9
26 wells syndrome 9.9
27 herpetiform pemphigus 9.8 DSG3 DSG1
28 bullous impetigo 9.8 DSG3 DSG1
29 impetigo 9.8 DSG3 DSG1
30 pseudomembranous conjunctivitis 9.8 DSG3 DSG1
31 iga pemphigus 9.8 DSG3 DSG1
32 pemphigus foliaceus 9.8 DSG3 DSG1
33 ritter's disease 9.8 DSG3 DSG1
34 pemphigoid gestationis 9.8 DSG3 DSG1
35 subcorneal pustular dermatosis 9.8 DSG3 DSG1
36 paraneoplastic pemphigus 9.8 DSG3 DSG1
37 lichen disease 9.8 DSG3 DSG1
38 tinea barbae 9.8 RPL10 PFN2 LINC01554
39 benign chronic pemphigus 9.8 DSG3 DSG1
40 pemphigus vulgaris, familial 9.7 DSG3 DSG1
41 pyoderma 9.7 DSG3 DSG1
42 autoimmune disease of skin and connective tissue 9.7 DSG3 DSG1
43 mucositis 9.7 DSG3 DSG1
44 lichen planus 9.7 DSG3 DSG1
45 bullous pemphigoid 9.6 DSG3 DSG1
46 autoimmune disease of musculoskeletal system 9.6 DSG3 DSG1
47 naxos disease 9.6 PKP3 DSG3 DSG1
48 bullous skin disease 9.5 PKP3 DSG3 DSG1
49 familial woolly hair syndrome 9.5 PKP3 DSG3 DSG1
50 pemphigus 9.5 PKP3 DSG3 DSG1

Graphical network of the top 20 diseases related to Tinea Imbricata:



Diseases related to Tinea Imbricata

Symptoms & Phenotypes for Tinea Imbricata

Human phenotypes related to Tinea Imbricata:

58 31 (show all 10)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 recurrent cutaneous abscess formation 58 31 hallmark (90%) Very frequent (99-80%) HP:0100838
2 fever 58 31 frequent (33%) Frequent (79-30%) HP:0001945
3 alopecia 58 31 frequent (33%) Frequent (79-30%) HP:0001596
4 lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0002716
5 myalgia 58 31 occasional (7.5%) Occasional (29-5%) HP:0003326
6 migraine 58 31 occasional (7.5%) Occasional (29-5%) HP:0002076
7 abnormality of metabolism/homeostasis 31 HP:0001939
8 abnormality of the skin 31 HP:0000951
9 recurrent skin infections 58 Very frequent (99-80%)
10 inflammatory abnormality of the skin 58 Very frequent (99-80%)

Symptoms via clinical synopsis from OMIM®:

57 (Updated 05-Mar-2021)
Skin:
tinea imbricata (ti) susceptibility

Lab:
trichophyton concentricum infection

Clinical features from OMIM®:

275240 (Updated 05-Mar-2021)

Drugs & Therapeutics for Tinea Imbricata

Drugs for Tinea Imbricata (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Sennoside A&B
2 Senna

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Senna Alata Leaf Decoction as a Treatment for Tinea Imbricata in an Indigenous Tribe in Southern Philippines :a Pilot Study Completed NCT03745183

Search NIH Clinical Center for Tinea Imbricata

Genetic Tests for Tinea Imbricata

Anatomical Context for Tinea Imbricata

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Imbricata:

19
Skin

MalaCards organs/tissues related to Tinea Imbricata:

40
Skin, Liver

Publications for Tinea Imbricata

Articles related to Tinea Imbricata:

(show top 50) (show all 179)
# Title Authors PMID Year
1
Genetic inheritance of susceptibility to tinea imbricata. 61 57
7218274 1980
2
Autosomal recessive inheritance of susceptibility to tinea imbricata. 61 57
63655 1977
3
Senna (Cassia) alata (Linn.) Roxb. leaf decoction as a treatment for tinea imbricata in an indigenous tribe in Southern Philippines. 61
32779266 2020
4
A case of kerion celsi caused by Trichophyton tonsurans. 61
32851760 2020
5
[Kerion Celsi on the vulva in a 15-year-old girl]. 61
32400368 2020
6
Tinea Capitis: Correlation of Clinical Aspects, Findings on Direct Mycological Examination, and Agents Isolated from Fungal Culture. 61
32030056 2019
7
Trichophyton tonsurans-induced kerion celsi with decreased defensin expression and paradoxically increased interleukin-17A production. 61
31294481 2019
8
Kerion of the pubis and vulva with bacterial superinfection: a rare occurrence. 61
31466986 2019
9
Tinea Pseudoimbricata as a Unique Manifestation of Steroid Abuse: A Clinico-Mycological and Dermoscopic Study from a Tertiary Care Hospital. 61
31334062 2019
10
Tinea capitis in adults: A 18-year retrospective, single-centre study in Korea. 61
30980768 2019
11
Molecular diagnosis of kerion celsi caused by Trichophyton tonsurans in a Italian child. 61
31080711 2019
12
Tinea Imbricata: An Overview. 61
30734680 2019
13
[Kerion Celsi]. 61
30869453 2018
14
Tinea Imbricata. 61
29747932 2018
15
Kerion celsi caused by Trichophyton tonsurans in a child. 61
29976531 2018
16
Fluctuating lesion of the scalp after a journey to the tropics: a case of furunculoid myiasis. 61
29630162 2018
17
Kerion Celsi with erythematous tumefaction on the groin due to Trichophyton mentagrophytes. 61
28757005 2017
18
[Acute skin infections and their imitators in children : A photo quiz]. 61
28914333 2017
19
Kerion celsi caused by Trichophyton erinacei from a hedgehog treated with terbinafine. 61
28869345 2017
20
Kerion Celsi due to Microsporum canis with a Dermatophytid Reaction. 61
28871931 2017
21
[A baby with progressive skin lesions on the scalp]. 61
28659203 2017
22
[A Case of Liver Dysfunction Requiring Hospital Admission after Taking Oral Itraconazole for the Treatment of Kerion Celsi]. 61
29187717 2017
23
Tinea Imbricata. 61
27959674 2016
24
Kerion Celsi Caused by Microsporum gypseum. 61
27567410 2016
25
[Tinea in the genital area : A diagnostic and therapeutic challenge]. 61
27488308 2016
26
[Trichophyton violaceum : Main cause of tinea capitis in children at Mbarara Regional Referral Hospital in Uganda]. 61
27341825 2016
27
[Trichophyton species of Arthroderma benhamiae : Clinical therapeutic aspects of a new pathogen in dermatology]. 61
27380384 2016
28
Kerion celsi: a misdiagnosed scalp infection. 61
26893521 2016
29
Successful treatment of severe kerion Celsi in an immunocompromised girl with evacuation of pus, terbinafine and short course glucocorticosteroids. 61
26852193 2016
30
Tinea Imbricata in an Italian Child and Review of the Literature. 61
26314408 2015
31
Trichophyton concentricum in skin lesions in children from the Salomon Islands. 61
26333549 2015
32
Are Dermatophytid Reactions in Patients with Kerion Celsi Much More Common Than Previously Thought? A Prospective Study. 61
25677472 2015
33
Bakua: tinea imbricata in the solomon islands. 61
25948556 2015
34
Tinea cruris and tinea corporis masquerading as tinea indecisiva: case report and review of the literature. 61
25775632 2015
35
Trichophyton tonsurans infection in Japan: epidemiology, clinical features, diagnosis and infection control. 61
25736317 2015
36
A case of tinea imbricata in an Italian woman. 61
24806878 2015
37
Kerion celsi of the vulva: an unusual location. 61
25459677 2014
38
Tinea imbricata as a clue to occult immunodeficiency. 61
25243976 2014
39
Tinea cruris and tinea corporis masquerading as tinea indecisiva: case report and review of the literature. 61
25277164 2014
40
Pharmacological management of pediatric Kerion celsi. 61
24355234 2013
41
Remember kerion celsi. 61
24005974 2013
42
Tinea corporis due to Trichophyton mentagrophytes and Trichophyton tonsurans mimicking tinea imbricata. 61
23760341 2013
43
Erythema nodosum induced by kerion celsi of the scalp in a child: a case report and mini-review of literature. 61
23121556 2013
44
Kerion caused by Microsporum audouinii in a child. 61
24432216 2013
45
Successful use of silver impregnated hydrofiber dressing in the treatment of kerion celsi caused by Microsporum gypseum. 61
24476613 2013
46
Kerion celsi due to Arthroderma incurvatum infection in a Sri Lankan child: species identification and analysis of area-dependent genetic polymorphism. 61
22443310 2012
47
Childhood erythema nodosum associated with kerion celsi: a case report and review of literature. 61
21692840 2012
48
Tinea capitis in the form of concentric rings in an HIV positive adult on antiretroviral treatment. 61
22837564 2012
49
[Kerion celsi]. 61
22997774 2012
50
Accidental Trichophyton mentagrophytes fungemia during the course of kerion celsi. 61
21819454 2012

Variations for Tinea Imbricata

Expression for Tinea Imbricata

Search GEO for disease gene expression data for Tinea Imbricata.

Pathways for Tinea Imbricata

Pathways related to Tinea Imbricata according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 PKP3 PFN2 DSG3 DSG1
2
Show member pathways
11.25 PKP3 DSG3 DSG1
3
Show member pathways
11.22 DSG3 DSG1

GO Terms for Tinea Imbricata

Cellular components related to Tinea Imbricata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell junction GO:0005911 9.33 PKP3 DSG3 DSG1
2 cornified envelope GO:0001533 9.13 PKP3 DSG3 DSG1
3 desmosome GO:0030057 8.8 PKP3 DSG3 DSG1

Biological processes related to Tinea Imbricata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.5 PKP3 DSG3 DSG1
2 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.4 DSG3 DSG1
3 regulation of translation GO:0006417 9.37 RPL10 PKP3
4 keratinization GO:0031424 9.33 PKP3 DSG3 DSG1
5 cell-cell junction assembly GO:0007043 9.26 PKP3 DSG1
6 cell-cell adhesion GO:0098609 9.13 PKP3 DSG3 DSG1
7 cornification GO:0070268 8.8 PKP3 DSG3 DSG1

Molecular functions related to Tinea Imbricata according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 translation regulator activity GO:0045182 8.62 RPL10 PKP3

Sources for Tinea Imbricata

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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