MCID: TNP002
MIFTS: 27

Tinea Profunda

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Tinea Profunda

MalaCards integrated aliases for Tinea Profunda:

Name: Tinea Profunda 12 15 70
Deep Seated Dermatophytosis 12 70
Granuloma Trichophyticum 12
Majocchi's Granuloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13368
SNOMED-CT 67 58950002
UMLS 70 C1279621 C1395264

Summaries for Tinea Profunda

Disease Ontology : 12 A tinea corporis that results in fungal infection located in skin, has material basis in Trichophyton mentagrophytes and results in formation of subcutaneous abscesses.

MalaCards based summary : Tinea Profunda, also known as deep seated dermatophytosis, is related to dermatophytosis and tinea pedis. An important gene associated with Tinea Profunda is CARD9 (Caspase Recruitment Domain Family Member 9), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and Tuberculosis. Affiliated tissues include skin, and related phenotypes are hematopoietic system and immune system

Wikipedia : 73 Dermatophytosis, also known as ringworm, is a fungal infection of the skin. Typically it results in a... more...

Related Diseases for Tinea Profunda

Diseases related to Tinea Profunda via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 dermatophytosis 30.0 CLEC7A CLEC6A CLEC4E CARD9
2 tinea pedis 29.7 CLEC7A CLEC6A CARD9
3 tinea corporis 29.4 CLEC7A CLEC6A CLEC4E CARD9
4 tinea capitis 29.3 CLEC7A CLEC6A CLEC4E CARD9
5 fungal infectious disease 28.9 DOCK8 CLEC7A CLEC6A CLEC4E CARD9
6 tinea cruris 10.1 CLEC6A CARD9
7 hypereosinophilic syndrome 10.1
8 candidiasis 10.0 CLEC7A CARD9
9 epidermolytic hyperkeratosis 10.0
10 ige responsiveness, atopic 10.0
11 kaposi sarcoma 10.0
12 systemic lupus erythematosus 10.0
13 immune deficiency disease 10.0
14 human immunodeficiency virus type 1 10.0
15 exanthem 10.0
16 autosomal recessive congenital ichthyosis 10.0
17 tinea manuum 10.0
18 keratosis 10.0
19 palmoplantar keratosis 10.0
20 pustulosis of palm and sole 10.0
21 acquired immunodeficiency syndrome 10.0
22 lupus erythematosus 10.0
23 psoriasis 10.0
24 pulmonary embolism 10.0
25 post-transplant lymphoproliferative disease 10.0
26 ichthyosis, x-linked 10.0
27 ichthyosis 10.0
28 autoimmune hepatitis 10.0
29 dermatitis 10.0
30 skin disease 10.0
31 folliculitis 10.0
32 alopecia 10.0
33 deep dermatophytosis 10.0
34 penicilliosis 10.0 CLEC7A CARD9
35 candidiasis, familial, 2 10.0 CLEC7A CARD9
36 adenoiditis 10.0 CLEC7A CARD9
37 common wart 10.0 CLEC6A CLEC4E
38 esophageal candidiasis 10.0 CLEC7A CARD9
39 sporotrichosis 10.0 CLEC7A CARD9
40 neuroaspergillosis 10.0 CLEC7A CARD9
41 ostertagiasis 9.9 CLEC7A CLEC4E
42 fungal keratitis 9.9 CLEC7A CLEC4E
43 vulvovaginal candidiasis 9.9 CLEC7A CARD9
44 vaginal disease 9.9 CLEC7A CARD9
45 corneal ulcer 9.9 CLEC7A CLEC6A
46 autoimmune polyendocrine syndrome type 1 9.9 CLEC7A CARD9
47 tinea barbae 9.8 CLYBL CARD9
48 hyper ige syndrome 9.8 DOCK8 CARD9
49 invasive aspergillosis 9.8 CLEC7A CLEC6A
50 cutaneous candidiasis 9.8 CLEC7A CLEC6A CARD9

Graphical network of the top 20 diseases related to Tinea Profunda:



Diseases related to Tinea Profunda

Symptoms & Phenotypes for Tinea Profunda

MGI Mouse Phenotypes related to Tinea Profunda:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.43 ALOXE3 CARD9 CLEC4E CLEC6A CLEC7A DOCK8
2 immune system MP:0005387 9.1 ALOXE3 CARD9 CLEC4E CLEC6A CLEC7A DOCK8

Drugs & Therapeutics for Tinea Profunda

Search Clinical Trials , NIH Clinical Center for Tinea Profunda

Genetic Tests for Tinea Profunda

Anatomical Context for Tinea Profunda

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Profunda:

19
Skin

MalaCards organs/tissues related to Tinea Profunda:

40
Skin

Publications for Tinea Profunda

Articles related to Tinea Profunda:

(show all 13)
# Title Authors PMID Year
1
Geophilic Tinea Profunda after a Stay at a Swiss Lake: A Case Report. 61
33708091 2021
2
Novel CARD9 mutation in a patient with chronic invasive dermatophyte infection (tinea profunda). 61
31469433 2020
3
Pubogenitale abszedierende Tinea profunda nach Intimrasur mit Nachweis von Trichophyton benhamiae. 61
29750444 2018
4
Tinea profunda of the genital area. Successful treatment of a rare skin disease. 61
26555874 2016
5
[Scarring tinea profunda in the pubic area due to Trichophyton verrucosum]. 61
16402270 2006
6
Tinea profunda cysticum caused by Trichophyton rubrum. 61
16427983 2006
7
Difficulties in diagnosing and treating tinea in adults at the Department of Dermatology in Bialystok (Poland). 61
14735603 2003
8
[Dermatophyte flora at the dermatology clinic of Kimitsu Chuo Hospital from 1994 through 1999]. 61
11865297 2002
9
[Fungal infection]. 61
9653557 1998
10
[What is your diagnosis? Tinea profunda]. 61
8506428 1993
11
[Tinea profunda and working conditions]. 61
1032157 1976
12
[Case suspected to be intra-ocular mycosis associated with tinea profunda]. 61
5169609 1971
13
Trichophytic granuloma (tinea profunda) due to Trichophyton Rubrum. 61
14893975 1952

Variations for Tinea Profunda

Expression for Tinea Profunda

Search GEO for disease gene expression data for Tinea Profunda.

Pathways for Tinea Profunda

GO Terms for Tinea Profunda

Biological processes related to Tinea Profunda according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.56 CLEC7A CLEC6A CLEC4E CARD9
2 positive regulation of interleukin-6 production GO:0032755 9.4 CLEC7A CARD9
3 positive regulation of tumor necrosis factor production GO:0032760 9.37 CLEC7A CARD9
4 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.32 CLEC7A CARD9
5 innate immune response GO:0045087 9.26 CLEC7A CLEC6A CLEC4E CARD9
6 positive regulation of stress-activated MAPK cascade GO:0032874 9.16 CLEC7A CARD9
7 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.8 CLEC6A CLEC4E CARD9

Molecular functions related to Tinea Profunda according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.13 CLEC7A CLEC6A CLEC4E
2 pattern recognition receptor activity GO:0038187 8.62 CLEC7A CLEC4E

Sources for Tinea Profunda

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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