MCID: TNP002
MIFTS: 26

Tinea Profunda

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Tinea Profunda

MalaCards integrated aliases for Tinea Profunda:

Name: Tinea Profunda 12 15 71
Deep Seated Dermatophytosis 12 71
Granuloma Trichophyticum 12
Majocchi's Granuloma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13368
SNOMED-CT 67 58950002
UMLS 71 C1279621 C1395264

Summaries for Tinea Profunda

Disease Ontology : 12 A tinea corporis that results in fungal infection located in skin, has material basis in Trichophyton mentagrophytes and results in formation of subcutaneous abscesses.

MalaCards based summary : Tinea Profunda, also known as deep seated dermatophytosis, is related to ichthyosis, x-linked and dermatophytosis. An important gene associated with Tinea Profunda is CARD9 (Caspase Recruitment Domain Family Member 9), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and Tuberculosis. Affiliated tissues include skin, and related phenotype is homeostasis/metabolism.

Wikipedia : 74 Dermatophytosis, also known as ringworm, is a fungal infection of the skin. Typically it results in a... more...

Related Diseases for Tinea Profunda

Diseases related to Tinea Profunda via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 ichthyosis, x-linked 30.1 NIPAL4 ALOXE3
2 dermatophytosis 29.8 CLEC7A CLEC6A CLEC4E CARD9
3 tinea corporis 29.6 CLEC6A CLEC4E CARD9 ALOXE3
4 epidermolytic hyperkeratosis 29.5 NIPAL4 ALOXE3
5 tinea pedis 29.2 CLEC7A CLEC6A CLEC4E CARD9
6 hypereosinophilic syndrome 10.2
7 tinea cruris 10.1 CLEC6A CARD9
8 ige responsiveness, atopic 10.1
9 kaposi sarcoma 10.1
10 systemic lupus erythematosus 10.1
11 immune deficiency disease 10.1
12 exanthem 10.1
13 tinea manuum 10.1
14 keratosis 10.1
15 dermatitis 10.1
16 palmoplantar keratosis 10.1
17 tinea capitis 10.1
18 pustulosis of palm and sole 10.1
19 acquired immunodeficiency syndrome 10.1
20 lupus erythematosus 10.1
21 psoriasis 10.1
22 pulmonary embolism 10.1
23 post-transplant lymphoproliferative disease 10.1
24 ichthyosis 10.1
25 autoimmune hepatitis 10.1
26 skin disease 10.1
27 folliculitis 10.1
28 alopecia 10.1
29 deep dermatophytosis 10.1
30 ichthyosis, congenital, autosomal recessive 7 10.0 NIPAL4 ALOXE3
31 ichthyosis, congenital, autosomal recessive 1 10.0 NIPAL4 ALOXE3
32 cutaneous candidiasis 10.0 CLEC7A CARD9
33 candidiasis 10.0 CLEC7A CARD9
34 common wart 10.0 CLEC6A CLEC4E
35 neuroaspergillosis 10.0 CLEC7A CARD9
36 penicilliosis 10.0 CLEC7A CARD9
37 ectropion 10.0 NIPAL4 ALOXE3
38 sporotrichosis 10.0 CLEC7A CARD9
39 ichthyosis, congenital, autosomal recessive 4b 10.0 NIPAL4 ALOXE3
40 hyper ige recurrent infection syndrome 1 10.0 CLEC7A CARD9
41 mucormycosis 10.0 CLEC7A CARD9
42 eyelid disease 10.0 NIPAL4 ALOXE3
43 superficial mycosis 9.9 CLEC7A CLEC6A
44 fungal keratitis 9.9 CLEC7A CLEC4E
45 pneumocystosis 9.9 CLEC7A CLEC6A
46 autoimmune polyendocrine syndrome type 1 9.9 CLEC7A CARD9
47 corneal ulcer 9.9 CLEC7A CLEC6A
48 vulvovaginal candidiasis 9.8 CLEC7A CARD9
49 cryptococcosis 9.8 CLEC7A CLEC6A
50 vaginal disease 9.8 CLEC7A CARD9

Graphical network of the top 20 diseases related to Tinea Profunda:



Diseases related to Tinea Profunda

Symptoms & Phenotypes for Tinea Profunda

MGI Mouse Phenotypes related to Tinea Profunda:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.1 ALOXE3 CARD9 CLEC4E CLEC7A CLYBL NIPAL4

Drugs & Therapeutics for Tinea Profunda

Search Clinical Trials , NIH Clinical Center for Tinea Profunda

Genetic Tests for Tinea Profunda

Anatomical Context for Tinea Profunda

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Profunda:

19
Skin

MalaCards organs/tissues related to Tinea Profunda:

40
Skin

Publications for Tinea Profunda

Articles related to Tinea Profunda:

(show all 12)
# Title Authors PMID Year
1
Novel CARD9 mutation in a patient with chronic invasive dermatophyte infection (tinea profunda). 61
31469433 2020
2
Pubogenitale abszedierende Tinea profunda nach Intimrasur mit Nachweis von Trichophyton benhamiae. 61
29750444 2018
3
Tinea profunda of the genital area. Successful treatment of a rare skin disease. 61
26555874 2016
4
[Scarring tinea profunda in the pubic area due to Trichophyton verrucosum]. 61
16402270 2006
5
Tinea profunda cysticum caused by Trichophyton rubrum. 61
16427983 2006
6
Difficulties in diagnosing and treating tinea in adults at the Department of Dermatology in Bialystok (Poland). 61
14735603 2003
7
[Dermatophyte flora at the dermatology clinic of Kimitsu Chuo Hospital from 1994 through 1999]. 61
11865297 2002
8
[Fungal infection]. 61
9653557 1998
9
[What is your diagnosis? Tinea profunda]. 61
8506428 1993
10
[Tinea profunda and working conditions]. 61
1032157 1976
11
[Case suspected to be intra-ocular mycosis associated with tinea profunda]. 61
5169609 1971
12
Trichophytic granuloma (tinea profunda) due to Trichophyton Rubrum. 61
14893975 1952

Variations for Tinea Profunda

Expression for Tinea Profunda

Search GEO for disease gene expression data for Tinea Profunda.

Pathways for Tinea Profunda

GO Terms for Tinea Profunda

Biological processes related to Tinea Profunda according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.56 CLEC7A CLEC6A CLEC4E CARD9
2 innate immune response GO:0045087 9.46 CLEC7A CLEC6A CLEC4E CARD9
3 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 9.37 CLEC7A CARD9
4 positive regulation of cytokine secretion GO:0050715 9.32 CLEC6A CLEC4E
5 pattern recognition receptor signaling pathway GO:0002221 8.96 CLEC7A CLEC4E
6 stimulatory C-type lectin receptor signaling pathway GO:0002223 8.8 CLEC6A CLEC4E CARD9

Molecular functions related to Tinea Profunda according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 8.8 CLEC7A CLEC6A CLEC4E

Sources for Tinea Profunda

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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