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MCID: TNN002
MIFTS: 47

Tinea Unguium

Categories: Infectious diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Tinea Unguium

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MalaCards integrated aliases for Tinea Unguium:

Name: Tinea Unguium 12 15 73
Cellulitis and Abscess of Upper Arm and Forearm 12
Cellulitis and Abscess of Finger and Toe 12
Cellulitis and Abscess of Gluteal Region 12
Cellulitis and Abscess of Buttock 12
Onychomycosis Due to Dermatophyte 12
Cellulitis and Abscess of Finger 12
Cellulitis and Abscess of Trunk 12
Cellulitis and Abscess of Face 12
Dermatophytic Onychomycosis 12
Dermatophytosis of Nail 12
Cellulitis and Abscess 12
Dermatophytic Onychia 12
Onychomycosis 73

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:13074
ICD9CM 35 681.9
ICD10 33 B35.1
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Summaries for Tinea Unguium

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Disease Ontology : 12 A dermatophytosis that results in fungal infection located in nail, has material basis in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

MalaCards based summary : Tinea Unguium, also known as cellulitis and abscess of upper arm and forearm, is related to acute dacryocystitis and tinea pedis, and has symptoms including thickening of subungueal area An important gene associated with Tinea Unguium is GPT (Glutamic--Pyruvic Transaminase), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and ADP signalling through P2Y purinoceptor 12. The drugs Ciclopirox and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and nail.

Wikipedia : 76 Onychomycosis, also known as tinea unguium, is a fungal infection of the nail. Symptoms may include... more...

Sources

Related Diseases for Tinea Unguium

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Diseases related to Tinea Unguium via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 acute dacryocystitis 29.5 CALM1 CALM2 CALM3
2 tinea pedis 10.7
3 uvulitis 10.3
4 dermatophytosis 10.3
5 cellulitis 10.3
6 erythema multiforme 10.2
7 tinea corporis 10.2
8 neuritis 10.2
9 tinea capitis 10.2
10 human immunodeficiency virus infectious disease 10.2
11 orbital cellulitis 10.1
12 dermatomycosis 10.1
13 pyridoxine deficiency 10.1 CBS GPT
14 dacryocystitis 10.0
15 separation anxiety disorder 9.9 HLA-B OPRM1
16 tinea cruris 9.9 CBS PPIG
17 long qt syndrome 9.9 CALM1 CALM2 CALM3
18 long qt syndrome 15 9.9 CALM1 CALM2 CALM3
19 long qt syndrome 1 9.9 CALM1 CALM2 CALM3
20 external ear disease 9.9 CALM1 CALM2 CALM3
21 emery-dreifuss muscular dystrophy 5, autosomal dominant 9.9 CALM1 CALM2 CALM3
22 sporotrichosis 9.9 CALM1 CALM2 CALM3
23 otitis externa 9.9 CALM1 CALM2 CALM3
24 spontaneous ocular nystagmus 9.9 CALM1 CALM2 CALM3
25 deafness, autosomal recessive 44 9.9 CALM1 CALM2 CALM3
26 dystonia 24 9.9 CALM1 CALM2 CALM3
27 gestational choriocarcinoma 9.9 CALM1 CALM2 CALM3
28 triosephosphate isomerase deficiency 9.9 CALM1 CALM2 CALM3
29 leber congenital amaurosis 2 9.9 CALM1 CALM2 CALM3
30 primary systemic mycosis 9.9 CALM1 CALM2 CALM3
31 clear cell acanthoma 9.9 CALM1 CALM2 CALM3
32 cardiomyopathy, dilated, 1a 9.9 CALM1 CALM2 CALM3
33 cardiomyopathy, dilated, 1p 9.9 CALM1 CALM2 CALM3
34 deafness, autosomal dominant 2a 9.9 CALM1 CALM2 CALM3
35 microcephaly 2, primary, autosomal recessive, with or without cortical malformations 9.8 CALM1 CALM2 CALM3
36 ceroid lipofuscinosis, neuronal, 11 9.8 CALM1 CALM2 CALM3
37 primary cutaneous amyloidosis 9.8 CALM1 CALM2 CALM3
38 catecholaminergic polymorphic ventricular tachycardia 9.8 CALM1 CALM2 CALM3
39 crohn's disease 9.8
40 crohn's colitis 9.8
41 branch retinal artery occlusion 9.8
42 central retinal artery occlusion 9.8
43 hidradenitis suppurativa 9.8
44 hidradenitis 9.8
45 retinal artery occlusion 9.8
46 impetigo 9.8
47 dacryoadenitis 9.8
48 fasciitis 9.8
49 necrotizing fasciitis 9.8
50 scleredema 9.8

Graphical network of the top 20 diseases related to Tinea Unguium:



Diseases related to Tinea Unguium
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Symptoms & Phenotypes for Tinea Unguium

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Symptoms:

12
  • • thickening of subungueal area
Sources

Drugs & Therapeutics for Tinea Unguium

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Drugs for Tinea Unguium (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ciclopirox Approved, Investigational Phase 4,Phase 3,Phase 2 29342-05-0 2749
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
3
Amorolfine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 78613-35-1
4
Terbinafine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 91161-71-6 1549008 5402
5
Bifonazole Approved, Investigational Phase 4,Phase 3,Not Applicable 60628-96-8 2378
6
Efinaconazole Approved Phase 4,Phase 3,Not Applicable 164650-44-6
7
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 84625-61-6 55283
8
Tavaborole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 174671-46-6
9 Keratolytic Agents Phase 4,Not Applicable
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
11 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
13 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Dermatologic Agents Phase 4,Not Applicable
15 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
16 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
18 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
19 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21
Hydroxyitraconazole Phase 4,Phase 3,Phase 2,Early Phase 1
22
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
23 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
24
Econazole Approved Phase 2 27220-47-9 3198
25
Naftifine Approved Phase 2 65472-88-0 47641 73342
26
Posaconazole Approved, Investigational, Vet_approved Phase 2,Not Applicable 171228-49-2 147912
27
Aminolevulinic acid Approved Phase 2,Not Applicable 106-60-5 137
28 Antiprotozoal Agents Phase 2,Not Applicable
29 Antiparasitic Agents Phase 2,Not Applicable
30
Ketoconazole Approved, Investigational Phase 1 65277-42-1 3823 47576
31 Tin Fluorides Phase 1
32
Tea tree oil Approved Not Applicable
33
Voriconazole Approved, Investigational Not Applicable 137234-62-9 71616
34
Petrolatum Approved, Investigational Early Phase 1 8009-03-8
35
Methylene blue Approved, Investigational Not Applicable 61-73-4
36 Tea Tree Not Applicable
37 Tea Not Applicable
38 English Lavender Not Applicable
39 Anti-Bacterial Agents Not Applicable
40 Photosensitizing Agents Not Applicable

Interventional clinical trials:

(show top 50) (show all 119)
# Name Status NCT ID Phase Drugs
1 Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis Unknown status NCT01014637 Phase 4 Amorolfine (Antifungal);RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal)
2 Evaluation of the Efficacy of CURE-EX Treatment in Onychomycosis Unknown status NCT02436291 Phase 4
3 A Pilot Study - Safety and Efficacy of Nailprotex® for Onychomycosis Treatment Completed NCT02464826 Phase 4 Nailprotex
4 Resin vs. Amorolfine vs. Terbinafine Treatment in Onychomycosis Completed NCT01851590 Phase 4 Amorolfine;Terbinafine
5 Scoring Clinical Index For Onychomycosis in Toenail Onychomycosis Treating With Itraconazole Capsules Completed NCT00871728 Phase 4 Itraconazole
6 Topical Penlac Nail Lacquer for Onychomycosis in Children Completed NCT01419847 Phase 4 Ciclopirox;Placebo
7 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer Completed NCT02679911 Phase 4 Loceryl NL;Ciclopirox NL
8 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1% Completed NCT02705664 Phase 4 Loceryl Nail Lacquer;Urea Ointment;Bifonazole Cream
9 An Evaluation of the Safety and Pharmacokinetics of Tavaborole Topical Solution for the Treatment of Fungal Disease of the Toenail in Children and Adolescents Completed NCT03405818 Phase 4 Tavaborole 5% Topical Solution
10 Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish Completed NCT02321098 Phase 4 Loceryl NL + Cosmetic varnish;Loceryl NL 12 weeks;Loceryl NL 15 months
11 Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis Recruiting NCT02812043 Phase 4 Amorolfine
12 Topical Amphotericin B in 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis Recruiting NCT03814343 Phase 4 amphotericin B in 30% DMSO;30% DMSO
13 Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Jublia® in Mild to Moderate Toenail Onychomycosis Recruiting NCT03280927 Phase 4 Jublia®
14 Safety and Pharmacokinetics of Efinaconazole Topical Solution in Subjects With Mild to Severe Onychomycosis Active, not recruiting NCT02812771 Phase 4 Efinaconazole
15 Evaluating the Efficacy and Compatibility of Efinaconazole 10% Solution (Jublia) for the Treatment of Toenail Onychomycosis in Patients Wearing Toenail Polish Compared to Those Without Polish Active, not recruiting NCT03110029 Phase 4 Efinaconazole 10% (Jublia)
16 Study Evaluating the Effect of Jublia on Dermatophytomas Active, not recruiting NCT03098615 Phase 4 Jublia (Efinaconazole 10% Topical Solution)
17 TDT 067 Onychomycosis Study Unknown status NCT01145807 Phase 3 TDT067;Placebo;Transfersome
18 Study to Evaluate the Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO) Unknown status NCT02866032 Phase 3 MOB015B;Ciclopirox 80 mg/g
19 Treating Onychomychosis Unknown status NCT00776464 Phase 2, Phase 3
20 Study to Evaluate the Efficacy and Safety of P-3058 10% Nail Solution in the Treatment of Toenail Onychomycosis Completed NCT02549001 Phase 3 P-3058 10%;vehicle of P-3058 10%;amorolfine 5%
21 Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01302119 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
22 Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01270971 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
23 Itraconazole Tablets Vs. Itraconazole Capsules vs. Placebo in Onychomycosis of the Toenail. Completed NCT00356915 Phase 3 Itraconazole 100mg capsules;Itraconazole 200mg tablets;Placebo tablets
24 Clinical Trial on Onychomycosis With P-3058 Nail Solution in Pediatric Population Completed NCT02547701 Phase 3 P-3058
25 Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride Versus 5% Amorolfine Nail Lacquer in Patients With Mild to Moderate Toenail Onychomycosis Completed NCT00459537 Phase 3 terbinafine hydrogen chloride;amorolfine nail lacquer
26 Safety and Efficacy of Luliconazole Solution, 10% in Subjects With Mild to Moderate Onychomycosis Completed NCT01431820 Phase 2, Phase 3 Luliconazole Solution, 10%;Vehicle Solution
27 PinPointe FootLaser for the Treatment of Onychomycosis Completed NCT00935649 Phase 2, Phase 3
28 Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01008033 Phase 3 IDP-108;Vehicle
29 The Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01007708 Phase 3 IDP-108;Vehicle
30 Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443820 Phase 3 terbinafine;Placebo;terbinafine;Placebo
31 Efficacy, Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443898 Phase 3 terbinafine;Placebo;terbinafine;Placebo
32 Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste Completed NCT00781820 Phase 3 Bifonazole cream 1%;Placebo cream
33 Efficacy and Safety of Efinaconazole 10% Solution in the Treatment of Onychomycosis in Diabetic Patients Active, not recruiting NCT03168841 Phase 3 Efinaconazole Topical
34 A Multi-centre, Double-blind, Randomized, Vehicle-controlled Study of Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO) Active, not recruiting NCT02859519 Phase 3 MOB015B;MOB015B Vehicle
35 Study Efficacy and Safety in Comparative Use of Investigational Product Adjuvant Treatment in Onychomycosis Not yet recruiting NCT02961634 Phase 3 Ciclopirox 8%
36 Antifungal Drugs in Treatment of Onychomycosis Not yet recruiting NCT03171584 Phase 3 Terbinafine
37 Safety & Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails Terminated NCT01208168 Phase 3 NAB001;Vehicle alone
38 Safety and Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails Terminated NCT01208129 Phase 3 NAB001;Placebo control
39 Study to Evaluate the Efficacy and Safety of P-3058 Nail Solution in the Treatment of Onychomycosis Withdrawn NCT03094468 Phase 3 P-3058 (terbinafine hydrochloride 10%);Vehicle of P-3058
40 Using Light Therapy to Treat Toe Nail Fungus Unknown status NCT00771732 Phase 2
41 Erbium-doped Yttrium Aluminium Garnet Laser(Er:Yag)Associated With Amorolfine Lacquer in the Treatment of Onychomycosis Unknown status NCT01528813 Phase 2 Amorolfine lacquer
42 A Trial of the Safety and Efficacy of EcoNailâ„¢ in the Treatment of Fungus Infections of the Great Toenail Unknown status NCT00385502 Phase 2 EcoNailâ„¢ (econazole 5%/SEPA® 18% nail lacquer)
43 Topical Gel Anti-Fungal Agent for Tinea Unguium Completed NCT00253305 Phase 2 Organogel of naftifine, 2%;Organogel of terbinafine, 2%;Organogel of naftifine, 6%;Organogel of terbinafine, 6%
44 Safety & Efficacy Study of HTU-520 in the Treatment of Distal Subungual Onychomycosis of the Toenail Completed NCT01400594 Phase 2 HTU-520 Patch
45 A Study to Evaluate Efficacy and Safety of Four Posaconazole Regimens With Placebo and Terbinafine in the Treatment of Toenail Onychomycosis (Study P05082AM2)(COMPLETED) Completed NCT00491764 Phase 2 SCH 56592;SCH 56592;SCH 56592;SCH 56592;Terbinafine;Placebo
46 Study of Different Doses of a Novel Treatment for Onychomycosis Completed NCT00679965 Phase 2 AN2690, 2.5%;AN2690, 5%;AN2690, 7.5%;AN2690 Solution Vehicle
47 A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Onychomycosis of the Toenail Completed NCT02267356 Phase 2 VT-1161;Placebo
48 Study of Different Doses of a Novel Treatment for Onychomycosis Completed NCT00679770 Phase 2 AN2690, 2.5%;AN2690, 5%;AN2690, 7.5%;Vehicle
49 Efficacy and Safety Study of Iontophoretic Application of Terbinafine Gel in Subjects With Onychomycosis Completed NCT01080079 Phase 2 Terbinafine Hydrochloride
50 Efficacy and Safety of Two Treatment Regimens of Topical MOB015 in Adults With Distal Subungual Onychomycosis Completed NCT01246518 Phase 2 MOB015

Search NIH Clinical Center for Tinea Unguium

Inferred drug relations via UMLS 73 / NDF-RT 51 :
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Genetic Tests for Tinea Unguium

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Anatomical Context for Tinea Unguium

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MalaCards organs/tissues related to Tinea Unguium:

41
Skin, Testes

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Unguium:

19
Nail
Sources

Publications for Tinea Unguium

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Articles related to Tinea Unguium:

(show top 50) (show all 55)
# Title Authors Year
1
Response to: Comment on "Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia". ( 29951161 )
2018
2
Tinea unguium onychomycosis caused by dermatophytes: a ten-year retrospective study (2005-2014) in a tertiary hospital in Singapore. ( 29552686 )
2018
3
Comment on "Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia". ( 29849837 )
2018
4
Topical efinaconazole: A promising therapeutic medication for tinea unguium. ( 30035311 )
2018
5
Ultrastructural changes of Trichophyton rubrum in tinea unguium after itraconazole therapy in vivo observed using scanning electron microscopy. ( 30387190 )
2018
6
Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia. ( 28852411 )
2017
7
Pathogenic Dermatophytes Survive in Nail Lesions During Oral Terbinafine Treatment for Tinea Unguium. ( 28281037 )
2017
8
Examining the accuracy of visual diagnosis of tinea pedis and tinea unguium in aged care facilities. ( 28379097 )
2017
9
Tinea Unguium: Diagnosis and Treatment in Practice. ( 27787643 )
2016
10
Clinical study of Dermatophyte Test Strip, an immunochromatographic method, to detect tinea unguium dermatophytes. ( 26992478 )
2016
11
Is the Dermatophyte Test Strip truly useful for the diagnosis of tinea unguium? Inquiry into "Clinical study of Dermatophyte Test Strip, an immunochromatographic method, to detect tinea unguium dermatophytes". ( 27910169 )
2016
12
Diagnostic accuracy of tinea unguium based on clinical observation. ( 25545551 )
2015
13
Screening for tinea unguium by thermography in older adults with subungual hyperkeratosis. ( 25311983 )
2014
14
Candida galli as a cause of tinea unguium-molecular characterization of a rare clinical fungal entity. ( 25037486 )
2014
15
A retrospective cohort study of tinea pedis and tinea unguium in inpatients in a psychiatric hospital. ( 24943206 )
2014
16
Screening for Tinea Unguium by Dermatophyte Test Strip. ( 24117339 )
2013
17
Rapid real-time diagnostic PCR for Trichophyton rubrum and Trichophyton mentagrophytes in patients with tinea unguium and tinea pedis using specific fluorescent probes. ( 23287391 )
2013
18
Disseminated erythema multiforme-like reaction triggered by tinea unguium. ( 21554422 )
2011
19
Optimized 5-hour multiplex PCR test for the detection of tinea unguium: performance in a routine PCR laboratory. ( 20105101 )
2010
20
Commentary: the illusory tinea unguium cure. ( 20159309 )
2010
21
Preventing long term relapsing tinea unguium with topical anti-fungal cream: a case report. ( 19154619 )
2009
22
Prevalence of tinea pedis, tinea unguium of toenails and tinea capitis in school children from Barcelona. ( 19766517 )
2009
23
Itraconazole concentrations of fingernails and toenails of patients with tinea unguium. ( 18477237 )
2008
24
In vitro antifungal susceptibility patterns of dermatophyte strains causing tinea unguium. ( 17714532 )
2007
25
Tinea pedis and tinea unguium in a 7-year-old child. ( 17644724 )
2007
26
Tinea unguium in the north-west of Iran (1996-2004). ( 17604428 )
2007
27
Twelve cases of tinea unguium in a pediatric clinic in 9 years. ( 17123110 )
2007
28
Epidemiology of tinea pedis and toenail tinea unguium in worshippers in the mosques in Adana, Turkey. ( 16361711 )
2005
29
Clinical and mycological study of occult tinea pedis and tinea unguium in dermatological patients from Tokyo. ( 12870199 )
2003
30
Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro. ( 12525893 )
2002
31
Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine. ( 12435679 )
2002
32
Smear positive leprosy with HIV infection, silent neuritis and extensive tinea corporis and tinea unguium in an Indian male. ( 11898467 )
2001
33
Tinea unguium in Lahore, Pakistan. ( 11346265 )
2001
34
Interferon-gamma production in peripheral lymphocytes of patients with tinea pedis: comparison of patients with and without tinea unguium. ( 11270412 )
2001
35
Prevalence and risk factors of tinea unguium and tinea pedis in the general population in Spain. ( 10970362 )
2000
36
Current topics in diagnosis and treatment of tinea unguium in Japan. ( 10091478 )
1999
37
A review of the epidemiology of tinea unguium in the community. ( 10098282 )
1999
38
Evaluation of 6 weeks treatment of terbinafine in tinea unguium in a double-blind trial comparing 6 and 12 weeks therapy. The Lagos V Study Group. ( 9205509 )
1997
39
Results of German multicenter study of antimicrobial susceptibilities of Trichophyton rubrum and Trichophyton mentagrophytes strains causing tinea unguium. German Collaborative Dermatophyte Drug Susceptibility Study Group. ( 7625820 )
1995
40
The proteolytic activity of strains of T. mentagrophytes and T. rubrum isolated from tinea pedis and tinea unguium infections. ( 7666296 )
1995
41
Short therapy for tinea unguium with terbinafine: four different courses of treatment. ( 8531933 )
1995
42
Clinical and pharmacokinetic investigations of oral terbinafine in patients with tinea unguium. ( 7477090 )
1995
43
Treatment of tinea unguium with medium and high doses of ultramicrosize griseofulvin compared with that with itraconazole. ( 8257124 )
1993
44
KONCPA: a new method for diagnosing tinea unguium. ( 8219416 )
1993
45
Is tinea unguium still widely incurable? A review three decades after the introduction of griseofulvin. ( 1531407 )
1992
46
Aetiology of onychomycosis and tinea unguium. ( 2530843 )
1989
47
A modified method to detect dermatophytes in the diagnosis of tinea unguium. ( 2961845 )
1987
48
A modified method for rapid mycological diagnosis of Tinea unguium in Taiwan, Republic of China. ( 2954779 )
1987
49
Tinea unguium. ( 2960495 )
1987
50
Urea plaster for softening diseased nails in the treatment of tinea unguium. ( 2962190 )
1986
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Variations for Tinea Unguium

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Expression for Tinea Unguium

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Search GEO for disease gene expression data for Tinea Unguium.
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Pathways for Tinea Unguium

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Pathways related to Tinea Unguium according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
CCR5 Pathway in Macrophages 64
Show member pathways
 12.79 CALM1 CALM2 CALM3 POLR2B
2
ADP signalling through P2Y purinoceptor 12 66
Show member pathways
 12.45 CALM1 CALM2 CALM3 OPRM1
3
Immune response Role of DAP12 receptors in NK cells 22
Show member pathways
 12.41 CALM1 CALM2 CALM3 HLA-B
4
DREAM Repression and Dynorphin Expression 64
Show member pathways
 12.39 CALM1 CALM2 CALM3 POLR2B
5
Metabolism of fat-soluble vitamins 66
Show member pathways
 12.24 CALM1 CALM2 CALM3
6
Development Ligand-independent activation of ESR1 and ESR2 22
Show member pathways
 12.23 CALM1 CALM2 CALM3
7
B Cell Receptor Signaling Pathway (sino) 67
Show member pathways
 12.23 CALM1 CALM2 CALM3
8
cAMP signaling pathway 37
Show member pathways
 12.2 CALM1 CALM2 CALM3
9
Platelet homeostasis 66
Show member pathways
 12.17 CALM1 CALM2 CALM3
10
Calcium signaling pathway 37
Show member pathways
 12.16 CALM1 CALM2 CALM3
11
Post NMDA receptor activation events 66
Show member pathways
 12.15 CALM1 CALM2 CALM3
12
Tuberculosis 37
12.14 CALM1 CALM2 CALM3
13
CD28 co-stimulation 66
Show member pathways
 12.12 CALM1 CALM2 CALM3
14
C-type lectin receptor signaling pathway 37
Show member pathways
 12.12 CALM1 CALM2 CALM3
15
Long-term potentiation 37
Show member pathways
 12.1 CALM1 CALM2 CALM3
16
Salivary secretion 37
Show member pathways
 12.09 CALM1 CALM2 CALM3
17
ADP signalling through P2Y purinoceptor 1 66
Show member pathways
 12.08 CALM1 CALM2 CALM3
18
Phototransduction 37
Show member pathways
 12.06 CALM1 CALM2 CALM3
19
Immune response Function of MEF2 in T lymphocytes 22
Show member pathways
 12.04 CALM1 CALM2 CALM3
20
Cellular senescence (KEGG) 37
12.03 CALM1 CALM2 CALM3 HLA-B
21
Fluid shear stress and atherosclerosis 37
12.01 CALM1 CALM2 CALM3
22
Apelin signaling pathway 37
12 CALM1 CALM2 CALM3
23
Translation Translation regulation by Alpha-1 adrenergic receptors 22
Show member pathways
 11.94 CALM1 CALM2 CALM3
24
Amphetamine addiction 37
Show member pathways
 11.92 CALM1 CALM2 CALM3
25
Inositol phosphate metabolism 66
Show member pathways
 11.89 CALM1 CALM2 CALM3
26
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 66
Show member pathways
 11.86 CALM1 CALM2 CALM3
27
Glucagon signaling pathway 37
11.85 CALM1 CALM2 CALM3
28
ErbB1 downstream signaling 1
11.84 CALM1 CALM2 CALM3
29
Visual Cycle in Retinal Rods 64
11.82 CALM1 CALM2 CALM3
30
Development EPO-induced Jak-STAT pathway 22
Show member pathways
 11.81 CALM1 CALM2 CALM3
31
Signaling events mediated by VEGFR1 and VEGFR2 1
Show member pathways
 11.78 CALM1 CALM2 CALM3
32
Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling 22
Show member pathways
 11.77 CALM1 CALM2 CALM3
33
Uptake and actions of bacterial toxins 66
Show member pathways
 11.7 CALM1 CALM2 CALM3
34
Metabolism of nitric oxide 66
Show member pathways
 11.69 CALM1 CALM2 CALM3
35
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.67 CALM1 CALM2 CALM3
36
Pertussis 37
11.66 CALM1 CALM2 CALM3
37
Phase 0 - rapid depolarisation 66
Show member pathways
 11.65 CALM1 CALM2 CALM3
38
Signal transduction_Erk Interactions- Inhibition of Erk 22
11.64 CALM1 CALM2 CALM3
39
IL2 signaling events mediated by PI3K 1
Show member pathways
 11.59 CALM1 CALM2 CALM3
40
Renin secretion 37
11.56 CALM1 CALM2 CALM3
41
Translocation of GLUT4 to the plasma membrane 66
11.54 CALM1 CALM2 CALM3
42
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.52 CALM1 CALM2 CALM3
43
Transcriptional Regulatory Network in Embryonic Stem Cell 64
11.48 CALM1 CALM2 CALM3
44
Cytoskeleton remodeling_RalA regulation pathway 22
11.44 CALM1 CALM2 CALM3
45
DNA damage_Role of Brca1 and Brca2 in DNA repair 22
11.44 CALM1 CALM2 CALM3 POLR2B
46
Role of Calcineurin-dependent NFAT signaling in lymphocytes 1
11.43 CALM1 CALM2 CALM3
47
Endothelin Pathways 1
11.26 CALM1 CALM2
48
Glycogen Metabolism 1
11.24 CALM1 CALM2 CALM3
49
Smooth Muscle Contraction 66
11.23 CALM1 CALM2 CALM3
50
T-Cell Receptor and Co-stimulatory Signaling 1
11.21 CALM1 CALM2
Sources

GO Terms for Tinea Unguium

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Cellular components related to Tinea Unguium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 9.61 CALM1 CALM2 CALM3
2 vesicle GO:0031982 9.58 CALM1 CALM2 CALM3
3 myelin sheath GO:0043209 9.54 CALM1 CALM2 CALM3
4 spindle pole GO:0000922 9.5 CALM1 CALM2 CALM3
5 sarcomere GO:0030017 9.43 CALM1 CALM2 CALM3
6 spindle microtubule GO:0005876 9.33 CALM1 CALM2 CALM3
7 calcium channel complex GO:0034704 9.13 CALM1 CALM2 CALM3
8 catalytic complex GO:1902494 8.8 CALM1 CALM2 CALM3

Biological processes related to Tinea Unguium according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 calcium-mediated signaling GO:0019722 9.78 CALM1 CALM2 CALM3
2 response to calcium ion GO:0051592 9.77 CALM1 CALM2 CALM3
3 positive regulation of protein serine/threonine kinase activity GO:0071902 9.76 CALM1 CALM2 CALM3
4 substantia nigra development GO:0021762 9.75 CALM1 CALM2 CALM3
5 regulation of cytokinesis GO:0032465 9.74 CALM1 CALM2 CALM3
6 regulation of heart rate GO:0002027 9.73 CALM1 CALM2 CALM3
7 positive regulation of peptidyl-threonine phosphorylation GO:0010800 9.71 CALM1 CALM2 CALM3
8 positive regulation of protein dephosphorylation GO:0035307 9.7 CALM1 CALM2 CALM3
9 positive regulation of protein autophosphorylation GO:0031954 9.69 CALM1 CALM2 CALM3
10 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 9.67 CALM1 CALM2 CALM3
11 response to amphetamine GO:0001975 9.65 CALM1 CALM3
12 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0010880 9.65 CALM1 CALM2 CALM3
13 activation of adenylate cyclase activity GO:0007190 9.64 CALM1 CALM3
14 positive regulation of DNA binding GO:0043388 9.64 CALM2 CALM3
15 positive regulation of nitric-oxide synthase activity GO:0051000 9.63 CALM1 CALM3
16 response to corticosterone GO:0051412 9.63 CALM1 CALM3
17 regulation of cardiac muscle contraction GO:0055117 9.63 CALM1 CALM2 CALM3
18 regulation of ryanodine-sensitive calcium-release channel activity GO:0060314 9.62 CALM1 CALM3
19 regulation of synaptic vesicle endocytosis GO:1900242 9.62 CALM1 CALM3
20 establishment of protein localization to membrane GO:0090150 9.61 CALM1 CALM3
21 negative regulation of peptidyl-threonine phosphorylation GO:0010801 9.61 CALM1 CALM2 CALM3
22 regulation of high voltage-gated calcium channel activity GO:1901841 9.6 CALM1 CALM3
23 positive regulation of phosphoprotein phosphatase activity GO:0032516 9.58 CALM1 CALM2 CALM3
24 establishment of protein localization to mitochondrial membrane GO:0090151 9.55 CALM1 CALM3
25 detection of calcium ion GO:0005513 9.54 CALM1 CALM2 CALM3
26 negative regulation of ryanodine-sensitive calcium-release channel activity GO:0060315 9.5 CALM1 CALM2 CALM3
27 positive regulation of ryanodine-sensitive calcium-release channel activity GO:0060316 9.43 CALM1 CALM2 CALM3
28 regulation of cell communication by electrical coupling involved in cardiac conduction GO:1901844 9.33 CALM1 CALM2 CALM3
29 positive regulation of cyclic-nucleotide phosphodiesterase activity GO:0051343 9.13 CALM1 CALM2 CALM3
30 positive regulation by host of symbiont cAMP-mediated signal transduction GO:0075206 8.8 CALM1 CALM2 CALM3

Molecular functions related to Tinea Unguium according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 protein domain specific binding GO:0019904 9.76 CALM1 CALM2 CALM3 OPRM1
2 ion channel binding GO:0044325 9.7 CALM1 CALM2 CALM3
3 disordered domain specific binding GO:0097718 9.61 CALM1 CALM2 CALM3
4 enzyme regulator activity GO:0030234 9.56 CALM1 CALM3
5 phosphatidylinositol 3-kinase binding GO:0043548 9.54 CALM1 CALM3
6 protein serine/threonine kinase activator activity GO:0043539 9.54 CALM1 CALM2 CALM3
7 nitric-oxide synthase binding GO:0050998 9.51 CALM1 CALM3
8 titin binding GO:0031432 9.5 CALM1 CALM2 CALM3
9 calcium channel inhibitor activity GO:0019855 9.49 CALM1 CALM2
10 nitric-oxide synthase regulator activity GO:0030235 9.48 CALM1 CALM3
11 adenylate cyclase binding GO:0008179 9.43 CALM1 CALM2 CALM3
12 type 3 metabotropic glutamate receptor binding GO:0031800 9.4 CALM1 CALM3
13 protein phosphatase activator activity GO:0072542 9.33 CALM1 CALM2 CALM3
14 adenylate cyclase activator activity GO:0010856 9.13 CALM1 CALM2 CALM3
15 N-terminal myristoylation domain binding GO:0031997 8.8 CALM1 CALM2 CALM3
16 protein binding GO:0005515 10.33 ARSI CALM1 CALM2 CALM3 CBS CNBP
17 metal ion binding GO:0046872 10.17 ARSI CALM1 CALM2 CALM3 CBS CNBP
Sources

Sources for Tinea Unguium

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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