Tinea Unguium disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: TNN002 MIFTS: 35	Tinea Unguium Categories: Infectious diseases, Skin diseases
Genes Variations Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Tinea Unguium

MalaCards integrated aliases for Tinea Unguium:

Name: Tinea Unguium ¹² ¹⁵ ⁷¹ ³²

Cellulitis and Abscess of Upper Arm and Forearm ¹²

Cellulitis and Abscess of Finger and Toe ¹²

Cellulitis and Abscess of Gluteal Region ¹²

Cellulitis and Abscess of Buttock ¹²

Onychomycosis Due to Dermatophyte ¹²

Cellulitis and Abscess of Finger ¹²

Cellulitis and Abscess of Trunk ¹²

Cellulitis and Abscess of Face ¹²

Dermatophytic Onychomycosis ¹²

Dermatophytosis of Nail ¹²

Cellulitis and Abscess ¹²

Dermatophytic Onychia ¹²

Onychomycosis ⁷¹

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Certain infectious and parasitic diseases

Mycoses

Dermatophytosis

Tinea unguium

External Ids:

Disease Ontology ¹² DOID:13074

ICD9CM ³⁴ 681.9

ICD10 ³² B35.1

UMLS ⁷¹ C0007644 C0040261 C4048550

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Summaries for Tinea Unguium

Disease Ontology : ¹² A dermatophytosis that results in fungal infection located in nail, has material basis in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

MalaCards based summary : Tinea Unguium, also known as cellulitis and abscess of upper arm and forearm, is related to dermatophytosis and dermatomycosis, and has symptoms including thickening of subungueal area An important gene associated with Tinea Unguium is STAT1 (Signal Transducer And Activator Of Transcription 1). The drugs Tazarotene and Ciclopirox have been mentioned in the context of this disorder. Affiliated tissues include nail, testes and skin.

Wikipedia : ⁷⁴ Onychomycosis, also known as tinea unguium, is a fungal infection of the nail. Symptoms may include... more...

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Related Diseases for Tinea Unguium

Diseases related to Tinea Unguium via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)

#	Related Disease	Score	Top Affiliating Genes
1	dermatophytosis	31.4	SQLE FLNA CBSL B4GALNT2
2	dermatomycosis	31.1	CBSL B4GALNT2
3	tinea capitis	30.8	SQLE CBSL B4GALNT2
4	tinea pedis	30.7	SQLE MSRA CBSL B4GALNT2
5	fungal infectious disease	30.3	STAT1 CRP CBSL B4GALNT2
6	tinea corporis	30.0	SQLE FLNA CBSL B4GALNT2
7	uvulitis	10.5
8	cellulitis	10.4
9	emphysematous cholecystitis	10.3	GPT CRP
10	ascending cholangitis	10.3	GPT CRP
11	ankylosing spondylitis 1	10.3	GPT CRP
12	splenic abscess	10.3	GPT CRP
13	critical illness polyneuropathy	10.3	GPT CRP
14	acalculous cholecystitis	10.3	GPT CRP
15	white piedra	10.3	CBSL B4GALNT2
16	tinea manuum	10.3	CBSL B4GALNT2
17	otomycosis	10.3	CBSL B4GALNT2
18	granulomatous hepatitis	10.3	GPT CRP
19	viral laryngitis	10.3	GPT CRP
20	trichosporonosis	10.3	CBSL B4GALNT2
21	acute cholangitis	10.3	GPT CRP
22	cholecystolithiasis	10.3	GPT CRP
23	eumycotic mycetoma	10.3	CBSL B4GALNT2
24	heart aneurysm	10.3	GPT CRP
25	coronary aneurysm	10.3	GPT CRP
26	splenic infarction	10.3	GPT CRP
27	phaeohyphomycosis	10.3	CBSL B4GALNT2
28	abdominal tuberculosis	10.3	GPT CRP
29	paralytic ileus	10.3	GPT CRP
30	48,xyyy	10.3
31	hydrops of gallbladder	10.3	GPT CRP
32	common bile duct disease	10.3	GPT CRP
33	pyuria	10.3	GPT CRP
34	pityriasis versicolor	10.3	SQLE CBSL
35	subcutaneous mycosis	10.3	CBSL B4GALNT2
36	kwashiorkor	10.3	GPT CRP
37	analbuminemia	10.3	GPT CRP
38	volvulus of midgut	10.3	GPT CRP
39	hypopyon	10.3	CRP B4GALNT2
40	superficial mycosis	10.3	CBSL B4GALNT2
41	leprosy 3	10.3
42	erythema multiforme	10.3
43	allergic hypersensitivity disease	10.3
44	paronychia	10.3
45	urticaria	10.3
46	keratosis	10.3
47	neuritis	10.3
48	human immunodeficiency virus infectious disease	10.3
49	bullous pemphigoid	10.3
50	chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids	10.3

Graphical network of the top 20 diseases related to Tinea Unguium:

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Symptoms & Phenotypes for Tinea Unguium

Symptoms:

¹²

• thickening of subungueal area

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Drugs & Therapeutics for Tinea Unguium

Drugs for Tinea Unguium (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Tazarotene

Approved, Investigational

Phase 4

118292-40-3

5381

Ciclopirox

Approved, Investigational

Phase 4

29342-05-0

2749

Amorolfine

Approved, Investigational

Phase 4

78613-35-1

carbamide peroxide

Approved

Phase 4

124-43-6

Tavaborole

Approved, Investigational

Phase 4

174671-46-6

Itraconazole

Approved, Investigational

Phase 4

84625-61-6

55283

Bifonazole

Approved, Investigational

Phase 4

60628-96-8

2378

Amphotericin B

Approved, Investigational

Phase 4

1397-89-3

5280965 14956

Dimethyl sulfoxide

Approved, Vet_approved

Phase 4

67-68-5

679

Efinaconazole

Approved

Phase 4

164650-44-6

Dermatologic Agents

Phase 4

Keratolytic Agents

Phase 4

Pharmaceutical Solutions

Phase 4

Cytochrome P-450 Enzyme Inhibitors

Phase 4

Hormone Antagonists

Phase 4

Hormones

Phase 4

Cytochrome P-450 CYP3A Inhibitors

Phase 4

Hydroxyitraconazole

Phase 4

Anti-Bacterial Agents

Phase 4

Antiprotozoal Agents

Phase 4

Antiparasitic Agents

Phase 4

Amebicides

Phase 4

Antioxidants

Phase 4

Protective Agents

Phase 4

Liposomal amphotericin B

Phase 4

Fluconazole

Approved, Investigational

Phase 3

86386-73-4

3365

Luliconazole

Approved

Phase 2, Phase 3

187164-19-8

Clotrimazole

Approved, Vet_approved

Phase 2

23593-75-1

2812

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Econazole

Approved

Phase 2

27220-47-9

3198

Isotretinoin

Approved

Phase 2

4759-48-2

5282379 5538

Naftifine

Approved

Phase 2

65472-88-0

47641 73342

Aminolevulinic acid

Approved

Phase 2

106-60-5

137

Posaconazole

Approved, Investigational, Vet_approved

Phase 2

171228-49-2

147912

Diclofenac

Approved, Vet_approved

Phase 2

15307-86-5

3033

Ethanol

Approved

Phase 2

64-17-5

702

Polihexanide

Approved, Investigational

Phase 2

28757-47-3

Albaconazole

Investigational

Phase 2

187949-02-6

Antifungal Agents

Phase 2

Immunosuppressive Agents

Phase 2

Immunologic Factors

Phase 2

Benzonidazole

Phase 2

Anti-Infective Agents, Local

Phase 2

Analgesics, Non-Narcotic

Phase 2

Analgesics

Phase 2

Cyclooxygenase Inhibitors

Phase 2

Anti-Inflammatory Agents

Phase 2

Antirheumatic Agents

Phase 2

Anti-Inflammatory Agents, Non-Steroidal

Phase 2

Anti-Infective Agents

Phase 2

Interventional clinical trials:

(show top 50) (show all 127)

#	Name	Status	NCT ID	Phase	Drugs
1	A Multicentre, Randomized, Controlled Study of the Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer Alone for the Treatment of Dermatophytic Onychomycosis (Toenail) Without Matrix Involvement	Unknown status	NCT01014637	Phase 4	Amorolfine (Antifungal);RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal)
2	Evaluation of the Efficacy of CURE-EX Treatment in Onychomycosis	Unknown status	NCT02436291	Phase 4
3	Efficacy of Combined Fractional Carbon Dioxide Laser and Topical Tazarotene in the Treatment of Psoriatic: Nail Disease a Single-blind, Intrapatient Left-to-right Controlled Study.	Unknown status	NCT03263624	Phase 4	Tazarotene Cream 0.1%
4	A Prospective, Double-blind, Placebo-controlled Trial of Topical Penlac Nail Lacquer for Therapy of Onychomycosis in Children	Completed	NCT01419847	Phase 4	Ciclopirox;Placebo
5	A Multicenter, Open Label, Single-arm Study Evaluating the Safety and Pharmacokinetics of Efinaconazole Topical Solution in Subjects With Mild to Severe Onychomycosis of the Toenails	Completed	NCT02812771	Phase 4	Efinaconazole
6	Evaluating the Efficacy and Compatibility of Efinaconazole 10% Solution (Jublia) for the Treatment of Toenail Onychomycosis in Patients Wearing Toenail Polish Compared to Those Without Polish	Completed	NCT03110029	Phase 4	Efinaconazole 10% Topical Application Solution [JUBLIA]
7	A Pilot Study - Safety and Efficacy of Nailprotex® for Onychomycosis Treatment	Completed	NCT02464826	Phase 4	Nailprotex
8	Efficacy of Topical Resin Lacquer, Amorolfine, and Oral Terbinafine for Treating Toenail Onychomycosis: a Prospective, Randomized, Controlled, Investigator-blinded, Parallel-group Clinical Trial	Completed	NCT01851590	Phase 4	Amorolfine;Terbinafine
9	Change in SCIO (Scoring Clinical Index For Onychomycosis) in Toenail Onychomycosis Treating With Itraconazole Capsules	Completed	NCT00871728	Phase 4	Itraconazole
10	An Investigator Initiated Pilot Study Evaluating the Efficacy of Efinaconazole 10% Solution (Jublia) for the Treatment of Onychomycosis With Dermatophytomas	Completed	NCT03098615	Phase 4	Jublia (Efinaconazole 10% Topical Solution)
11	Subject Adherence and Satisfaction for Treatment of Onychomycosis With Loceryl Nail Lacquer 5% Versus Ciclopirox Nail Lacquer	Completed	NCT02679911	Phase 4	Loceryl NL;Ciclopirox NL
12	Subject Adherence and Satisfaction for Treatment of Onychomycosis With Loceryl Nail Lacquer 5% Versus a Fungal Nail Treatment Set Containing Urea 40% Ointment and Bifonazole Cream 1%	Completed	NCT02705664	Phase 4	Loceryl Nail Lacquer;Urea Ointment;Bifonazole Cream
13	Determination of Antifungal Activity of Loceryl Nail Lacquer 5% When Used Concomitantly With a Cosmetic Nail Varnish Compared to a Loceryl Nail Lacquer (NL) 5% Alone in Treatment of Toenail Distal Subungual Onychomycosis	Completed	NCT02321098	Phase 4	Loceryl NL + Cosmetic varnish;Loceryl NL 12 weeks;Loceryl NL 15 months
14	An Open-label Study To Evaluate The Safety, Tolerability, And Pharmacokinetics Of Kerydin (Registered) (Tavaborole) Topical Solution, 5% In The Treatment Of Onychomycosis Of The Toenail In Pediatric Subjects Ages 6 To 16 Years And 11 Months	Completed	NCT03405818	Phase 4	Tavaborole 5% Topical Solution
15	Comparison of the Efficacy and Safety Between Long-pulsed Nd:YAG, Amorolfine and Combination of Long-pulsed Nd:YAG and Amorolfine in Treating Non-dermatophyte and Mixed-infection Onychomycosis	Recruiting	NCT02812043	Phase 4	Amorolfine
16	Comparison of Effectiveness of Topical Amphotericin B in 30% Dimethylsulphoxide and 30% Dimethylsulphoxide in Treating of Non-dermatophytes Onychomycosis: Randomized Double Blind Controlled Trial Pilot Study	Recruiting	NCT03814343	Phase 4	amphotericin B in 30% DMSO;30% DMSO
17	A Multicenter, Open-label, Non-controlled, Single-arm Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Jublia® in Mild to Moderate Toenail Onychomycosis	Active, not recruiting	NCT03280927	Phase 4	Jublia®
18	Comparative Study of Systemic Antifungal Drugs Used in Treatment of Onychomycosis	Unknown status	NCT03171584	Phase 3	Terbinafine
19	Treating Onychomychosis	Unknown status	NCT00776464	Phase 2, Phase 3
20	Study Efficacy and Safety in Comparative Use of Investigational Product Adjuvant Treatment in Onychomycosis	Unknown status	NCT02961634	Phase 3	Ciclopirox 8%
21	A Randomized, Double-blind, Vehicle- and Placebo-Controlled, Multicenter Trial in Patients With Mild to Moderate Distal Subungual Toenail Onychomycosis to Investigate the Efficacy, Tolerability, and Safety of Twice Daily Application of TDT 067 for 48 Weeks	Unknown status	NCT01145807	Phase 3	TDT067;Placebo;Transfersome
22	A Randomized, Double-blind, Vehicle-controlled, Multicenter, Parallel Group Study to Assess the Efficacy, Safety, and Tolerability of Topical Terbinafine Hydrogen Chloride (HCl) Formulation for 24 or 48 Weeks of Treatment in Patients With Mild to Moderate Toenail Onychomycosis	Completed	NCT00443898	Phase 3	terbinafine;Placebo;terbinafine;Placebo
23	A Randomized, Double-blind, Vehicle-controlled, Multicenter, Parallel Group Study to Assess the Efficacy, Safety, and Tolerability of Topical Terbinafine Hydrogen Chloride (HCl) Formulation for 24 or 48 Weeks of Treatment in Patients With Mild to Moderate Toenail Onychomycosis	Completed	NCT00443820	Phase 3	terbinafine;Placebo;terbinafine;Placebo
24	A Randomized, Double-Blind, Vehicle-Controlled, Multi-Center Study to Evaluate the Efficacy and Safety of AN2690 Topical Solution, 5%, vs. Solution Vehicle in the Treatment of Onychomycosis of the Toenail in Adults	Completed	NCT01302119	Phase 3	AN2690 Topical Solution, 5%;Solution Vehicle
25	A Randomized, Double-Blind, Vehicle-Controlled, Multi-Center Study to Evaluate the Efficacy and Safety of AN2690 Topical Solution, 5%, vs. Solution Vehicle in the Treatment of Onychomycosis of the Toenail in Adults	Completed	NCT01270971	Phase 3	AN2690 Topical Solution, 5%;Solution Vehicle
26	A Randomized, Open-label, Active-controlled, Multicenter, Parallel Group Study to Assess the Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride (HCl) Formulation Versus 5% Amorolfine Nail Lacquer for 48 Weeks of Treatment in Patients With Mild to Moderate Toenail Onychomycosis	Completed	NCT00459537	Phase 3	terbinafine hydrogen chloride;amorolfine nail lacquer
27	A Multicenter, Randomized, Double-blind, Parallel, Vehicle-controlled Study to Evaluate the Efficacy and Safety of P-3058 10% Nail Solution in the Treatment of Onychomycosis	Completed	NCT02549001	Phase 3	P-3058 10%;vehicle of P-3058 10%;amorolfine 5%
28	Multicentre, Open Label Study to Assess the Tolerability of P-3058 Nail Solution in Paediatric Patients Affected by Mild-to-moderate Onychomycosis	Completed	NCT02547701	Phase 3	P-3058
29	Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis	Completed	NCT01008033	Phase 3	IDP-108;Vehicle
30	The Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis	Completed	NCT01007708	Phase 3	IDP-108;Vehicle
31	Safety and Efficacy of Luliconazole Solution, 10% With Two Dosing Regimens in Distal Subungual Onychomycosis of the Toenails: A Randomized, Double-Blind, Vehicle-Controlled, Phase 2B/3 Study	Completed	NCT01431820	Phase 2, Phase 3	Luliconazole Solution, 10%;Vehicle Solution
32	A Phase III Randomized, Evaluator-Blind, Parallel Group Study of the Safety and Efficacy of Itraconazole Tablets, Itraconazole Capsules and Placebo in the Treatment of Onychomycosis of the Toenail.	Completed	NCT00356915	Phase 3	Itraconazole 100mg capsules;Itraconazole 200mg tablets;Placebo tablets
33	Efficacy and Safety of Efinaconazole 10% Solution in the Treatment of Onychomycosis in Diabetic Patients	Completed	NCT03168841	Phase 3	Efinaconazole Topical
34	A Double-blind, Randomized, Multicenter, Placebo- Controlled Phase 3 Trial to Prove the Superiority of Bifonazole vs. Placebo After 4 Weeks of Onychomycosis Treatment/ as a Follow-up of a 2 Weeks Treatment of Non-surgical Nail Ablation of Diseased Nail Matrix With 40% Urea Paste	Completed	NCT00781820	Phase 3	Bifonazole cream 1%;Placebo cream
35	Multi-Center Trial: Evaluation of PinPointe FootLaser Treatment for Infected Toenails (Onychomycosis)	Completed	NCT00935649	Phase 2, Phase 3
36	A Multi-centre, Randomized, Two-armed, Parallel Group and Evaluator-blinded Study of Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO)	Active, not recruiting	NCT02866032	Phase 3	MOB015B;Ciclopirox 80 mg/g
37	A Multi-centre, Double-blind, Randomized, Vehicle-controlled Study of Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO)	Active, not recruiting	NCT02859519	Phase 3	MOB015B;MOB015B Vehicle
38	A Randomized, Double-Blind, Vehicle-Controlled, Multicenter, Parallel Group Study of the Safety and Efficacy of NAB001 in the Treatment of Mild to Moderate Distal Subungual Onychomycosis of the Toenails for 52 Wks	Terminated	NCT01208168	Phase 3	NAB001;Vehicle alone
39	A Randomized, Double-Blind, Vehicle-Controlled, Multicenter, Parallel Group Study of the Safety and Efficacy of NAB001 in the Treatment of Mild to Moderate Distal Subungual Onychomycosis of the Toenails for 52 Weeks	Terminated	NCT01208129	Phase 3	NAB001;Placebo control
40	A Multicenter, Randomized, Double-blind, Parallel, Vehicle-controlled Study to Evaluate the Efficacy and Safety of P-3058 10% Nail Solution in the Treatment of Onychomycosis	Withdrawn	NCT03094468	Phase 3	P-3058 (terbinafine hydrochloride 10%);Vehicle of P-3058
41	The Efficacy of CELEXT07 in the Treatment of Toenail Onychomycosis: a Phase 2, Randomized, Double-blind Study	Unknown status	NCT02644551	Phase 2	CELEXT07;Penlac
42	Noveon Laser Treatment of Onychomycosis: A Device Performance Clinical Study	Unknown status	NCT00771732	Phase 2
43	A Phase II Trial of the Safety, Local Tolerability, and Efficacy of EcoNail™ (Econazole 5%/SEPA® 18% Nail Lacquer) in Onychomycosis of the Great Toenail	Unknown status	NCT00385502	Phase 2	EcoNail™ (econazole 5%/SEPA® 18% nail lacquer)
44	AVALIAÇÃO DO USO DO LASER ERBIUM-DOPED YTTRIUM ALUMINIUM GARNET (Er:YAG) ASSOCIADO AO ESMALTE DE AMOROLFINA NO TRATAMENTO DA ONICOMICOSE	Unknown status	NCT01528813	Phase 2	Amorolfine lacquer
45	Phase 2 Randomized, Multicenter, Placebo-controlled, Safety and Efficacy Study to Evaluate Three Oral E1224 Dosing Regimens and Benznidazole for the Treatment of Adult Patients With Chronic Indeterminate Chagas Disease	Unknown status	NCT01489228	Phase 2	E1224;Benznidazole;Placebo
46	A Pilot Study to Assess The Therapeutic Effectiveness Of Isotretinoin In Preventing Recurrences In Chronic Recurrent Dermatophytosis	Unknown status	NCT03471455	Phase 2	Isotretinoin;Terbinafine;Itraconazole 200 mg
47	Phase IIB Efficacy and Safety Study of Four Topical Gel Formulations of Anti-Fungal Agents, MQX-5858, MQX-5859, MQX-5866, and MQX-5867, Versus Vehicle in the Treatment of Tinea Unguium.	Completed	NCT00253305	Phase 2	Organogel of naftifine, 2%;Organogel of terbinafine, 2%;Organogel of naftifine, 6%;Organogel of terbinafine, 6%
48	An Unblinded Clinical Trial to Evaluate the Deposition of Terbinafine in the Nail Bed After Iontophoretic Application of ETS Terbinafine Gel in Subjects With Distal Subungual Onychomycosis in the Great Toenail	Completed	NCT01484145	Phase 2	Terbinafine HCl
49	An Open-label, Multiple-dose Study Of The Absorption And Systemic Pharmacokinetics Of An2690 Applied As A 7.5% Solution To All Toenails Of Adult Patients With Moderate To Severe Onychomycosis	Completed	NCT00680160	Phase 2	AN2690
50	A Subject Blinded, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Iontophoretic Application of ETS Terbinafine Gel in Subjects With Distal Subungual Onychomycosis in the Great Toenail	Completed	NCT01080079	Phase 2	Terbinafine Hydrochloride

Search NIH Clinical Center for Tinea Unguium

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

ciclopirox

Ciclopirox olamine

Itraconazole

tavaborole

terbinafine

Terbinafine hydrochloride

Sources

Genetic Tests for Tinea Unguium

Sources

Anatomical Context for Tinea Unguium

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Unguium:

¹⁹

Nail

MalaCards organs/tissues related to Tinea Unguium:

⁴⁰

Testes, Skin

Sources

Publications for Tinea Unguium

Articles related to Tinea Unguium:

(show top 50) (show all 276)

#	Title	Authors	PMID	Year
1	Epidemiological survey of 42 403 dermatophytosis cases examined at Nagasaki University Hospital from 1966 to 2015. ⁶¹	Takenaka M...Nishimoto K	32293052	2020
2	Whole-genome resequencing of Trichophyton rubrum provides insights into population differentiation and drug resistance. ⁶¹	Zheng H...Liu W	31538279	2020
3	Skin Infections and Outpatient Burn Management: Fungal and Viral Skin Infections. ⁶¹	Woolever DR	31995350	2020
4	Molecular identification of isolates of the Trichophyton mentagrophytes complex. ⁶¹	Frias-De-Leon MG...Rodriguez-Cerdeira C	31929737	2020
5	Epidemiology of dermatophytic infections between 2008 and 2017 in Barcelona, Spain. ⁶¹	Antuori A...Matas L	31076176	2019
6	Tinea unguium caused by terbinafine-resistant Trichophyton rubrum successfully treated with fosravuconazole. ⁶¹	Noguchi H...Ihn H	31353607	2019
7	In search of the source of dermatophytosis: Epidemiological analysis of Trichophyton verrucosum infection in llamas and the breeder (case report). ⁶¹	Lagowski D...Zieba P	31538413	2019
8	Internal environment of footwear is a risk factor for tinea pedis. ⁶¹	Sasagawa Y	31436337	2019
9	Epidemiology of dermatophytosis in northeastern Iran; A subtropical region. ⁶¹	Ebrahimi M...Novak Babic M	31321333	2019
10	Terbinafine-resistant strain of Trichophyton interdigitale strain isolated from a tinea pedis patient. ⁶¹	Hiruma J...Harada K	30768808	2019
11	Differences Between Patient-Reported Versus Clinician-Observed Nonulcerative Signs and Symptoms of the Foot in Patients With Diabetes Mellitus. ⁶¹	Takehara K...Sanada H	30747799	2019
12	Characteristics and Efficacy of Two Topical Therapeutic Agents for Onychomycosis. ⁶¹	Kawai M	31474693	2019
13	Detection of Trichophyton rubrum and Trichophyton interdigitale in onychomycosis using monoclonal antibodies against Sub6 (Tri r 2). ⁶¹	Mehul B...Monod M	30152879	2019
14	2016 Epidemiological Survey of Dermatomycoses in Japan. ⁶¹	Shimoyama H...Sei Y	31474694	2019
15	Epidemiological and clinical aspects of dermatophytoses in Eastern Slovakia: a retrospective three-year study. ⁶¹	Baranova Z...Rimarova K	30817878	2018
16	Ultrastructural changes of Trichophyton rubrum in tinea unguium after itraconazole therapy in vivo observed using scanning electron microscopy. ⁶¹	Yue X...Li Q	30387190	2018
17	Molecular Epidemiological Analysis of the Spreading Conditions of Trichophyton in Long-Term Care Facilities in Japan. ⁶¹	Suzuki S...Fujitani K	30175735	2018
18	Topical efinaconazole: A promising therapeutic medication for tinea unguium. ⁶¹	Noguchi H...Ihn H	30035311	2018
19	Tinea unguium onychomycosis caused by dermatophytes: a ten-year (2005-2014) retrospective study in a tertiary hospital in Singapore. ⁶¹	Pang SM...Tan AL	29552686	2018
20	Epidemiology of dermatophytoses in 31 municipalities of the province of Buenos Aires, Argentina: A 6-year study. ⁶¹	Mazza M...Mycology Network of the Province of Buenos Aires (MNPBA)	29606407	2018
21	Characterizing the clinical isolates of dermatophytes in Hamadan city, Central west of Iran, using PCR-RLFP method. ⁶¹	Farokhipor S...Didehdar M	29439839	2018
22	Subungual Amelanotic Melanoma Masquerading as Onychomycosis. ⁶¹	Riahi RR...Goldberg LH	29755903	2018
23	Common Child and Adolescent Cutaneous Infestations and Fungal Infections. ⁶¹	Alter SJ...Trevino J	29198783	2018
24	Comment on "Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia". ⁶¹	Badri T	29849837	2018
25	Response to: Comment on "Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia". ⁶¹	Toukabri N...Sadfi-Zouaoui N	29951161	2018
26	Recurrent dermatophytosis: A rising problem in Sikkim, a Himalayan state of India. ⁶¹	Sharma R...Sharma RL	29323069	2017
27	High prevalence of superficial white onychomycosis by Trichophyton interdigitale in a Japanese nursing home with a geriatric hospital. ⁶¹	Watanabe S...Mochizuki T	28436564	2017
28	Epidemiology of dermatomycoses in Kerman province, southeast of Iran: A 10-years retrospective study (2004-2014). ⁶¹	Salari S...Izadi A	28757272	2017
29	Pathogenic Dermatophytes Survive in Nail Lesions During Oral Terbinafine Treatment for Tinea Unguium. ⁶¹	Iwanaga T...Mochizuki T	28281037	2017
30	Examining the accuracy of visual diagnosis of tinea pedis and tinea unguium in aged care facilities. ⁶¹	Goto T...Sanada H	28379097	2017
31	Epidemiological status of dermatophytosis in Guilan, north of Iran. ⁶¹	Fallahi AA...Rezaei S	29302626	2017
32	New Antifungal Agents and New Formulations Against Dermatophytes. ⁶¹	Gupta AK...Versteeg SG	27502503	2017
33	Tinea Unguium: Diagnosis and Treatment in Practice. ⁶¹	Asz-Sigall D...Arenas R	27787643	2017
34	Dermatophyte Antigen Kit. ⁶¹	Tsunemi Y	28566667	2017
35	[Affinity of Luliconazole for Human Nail Derived Keratin]. ⁶¹	Hasuko M...Inagaki K	29187718	2017
36	Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia. ⁶¹	Toukabri N...Sadfi-Zouaoui N	28852411	2017
37	Characterization of clinically important dermatophytes in North of Iran using PCR-RFLP on ITS region. ⁶¹	Didehdar M...Mondanizadeh M	27496524	2016
38	Is the Dermatophyte Test Strip truly useful for the diagnosis of tinea unguium? Inquiry into "Clinical study of Dermatophyte Test Strip, an immunochromatographic method, to detect tinea unguium dermatophytes". ⁶¹	Watanabe S	27910169	2016
39	[Causative agents of superficial mycoses isolated in Dakar, Senegal: Retrospective study from 2011 to 2015]. ⁶¹	Diongue K...Ndiaye D	27592054	2016
40	[Tinea unguium with Microsporum langeronii and Trichophyton soudanense revealing tinea capitis with M. langeronii]. ⁶¹	Diongue K...Ndiaye D	27592053	2016
41	Clinical study of Dermatophyte Test Strip, an immunochromatographic method, to detect tinea unguium dermatophytes. ⁶¹	Tsunemi Y...Hiruma M	26992478	2016
42	Production of an anti-dermatophyte monoclonal antibody and its application: immunochromatographic detection of dermatophytes. ⁶¹	Noriki S...Ishida H	27250927	2016
43	Identification of three yeast species using the conventional and internal transcribed spacer region sequencing methods as first or second global record from human superficial infections. ⁶¹	Abdel-Sater MA...Soliman Z	27392537	2016
44	Protocol for the systematic review of the prevention, treatment and public health management of impetigo, scabies and fungal skin infections in resource-limited settings. ⁶¹	May P...Carapetis J	27659511	2016
45	Epidemiological Aspects of Dermatophytosis in Khuzestan, southwestern Iran, an Update. ⁶¹	Rezaei-Matehkolaei A...Sadeghi-Nejad B	26886443	2016
46	Epidemiology of Superficial Fungal Infections in Guangdong, Southern China: A Retrospective Study from 2004 to 2014. ⁶¹	Cai W...Yu X	26883512	2016
47	[Superficial mycoses: casuistry of the Mycology Department of the Instituto Nacional de Higiene "Rafael Rangel", Caracas, Venezuela (2001-2014)]. ⁶¹	Capote AM...Dolande M	27382801	2016
48	Molecular Characterization and In Vitro Antifungal Susceptibility of 316 Clinical Isolates of Dermatophytes in Iran. ⁶¹	Ansari S...Seyedmousavi S	26369643	2016
49	Development and Evaluation of a Novel Real-Time PCR for Pan-Dermatophyte Detection in Nail Specimens. ⁶¹	Gong J...Li R	26412381	2016
50	[Affinity of Luliconazole to Keratin Prepared from Healthy Human Nailand Porcine Hoof]. ⁶¹	Hasuko M...Tsuboi R	26936352	2016

Sources

Genes for Tinea Unguium

Genes related to Tinea Unguium (1 elite genes):

(show all 12)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	403.37	Pathogenic ⁶ DISEASES inferred ¹⁵
2	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	7.2	GeneCards inferred via : Publications (show sections)
3	SQLE	Squalene Epoxidase	Protein Coding	6.25	DISEASES inferred ¹⁵
4	B4GALNT2	Beta-1,4-N-Acetyl-Galactosaminyltransferase 2	Protein Coding	6.19	DISEASES inferred ¹⁵
5	TRIR	Telomerase RNA Component Interacting RNase	Protein Coding	5.51	DISEASES inferred ¹⁵
6	CBSL	Cystathionine Beta-Synthase Like	Protein Coding	5.32	DISEASES inferred ¹⁵
7	CRP	C-Reactive Protein	Protein Coding	5.03	DISEASES inferred ¹⁵
8	UNK	Unk Zinc Finger	Protein Coding	4.92	DISEASES inferred ¹⁵
9	FLNA	Filamin A	Protein Coding	4.82	DISEASES inferred ¹⁵
10	MSRA	Methionine Sulfoxide Reductase A	Protein Coding	4.8	DISEASES inferred ¹⁵
11	SUB1	SUB1 Regulator Of Transcription	Protein Coding	4.79	DISEASES inferred ¹⁵
12	ARSI	Arylsulfatase Family Member I	Protein Coding	4.74	DISEASES inferred ¹⁵

Sources

Variations for Tinea Unguium

ClinVar genetic disease variations for Tinea Unguium:

⁶ ‎‎

#	Gene	Name	Type	Significance	ClinVarId	dbSNP ID	GRCh37 Pos	GRCh38 Pos
1	STAT1	NM_007315.3(STAT1):c.821G>A (p.Arg274Gln)	SNV	Pathogenic	30085	rs387906760	2:191859910-191859910	2:190995184-190995184

Sources

Expression for Tinea Unguium

Search GEO for disease gene expression data for Tinea Unguium.

Sources

Pathways for Tinea Unguium

Sources

GO Terms for Tinea Unguium

Sources

Sources for Tinea Unguium

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia

Tinea Unguium

Aliases & Classifications for Tinea Unguium

MalaCards integrated aliases for Tinea Unguium:

Classifications:

External Ids:

Summaries for Tinea Unguium

Related Diseases for Tinea Unguium

Diseases related to Tinea Unguium via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Tinea Unguium:

Symptoms & Phenotypes for Tinea Unguium

Symptoms:

Drugs & Therapeutics for Tinea Unguium

Drugs for Tinea Unguium (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 71 / NDF-RT 50 :

Genetic Tests for Tinea Unguium

Anatomical Context for Tinea Unguium

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Unguium:

MalaCards organs/tissues related to Tinea Unguium:

Publications for Tinea Unguium

Articles related to Tinea Unguium:

Genes for Tinea Unguium

Genes related to Tinea Unguium (1 elite genes):

Variations for Tinea Unguium

ClinVar genetic disease variations for Tinea Unguium:

Expression for Tinea Unguium

Pathways for Tinea Unguium

GO Terms for Tinea Unguium

Sources for Tinea Unguium

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :