MCID: TNN002
MIFTS: 35

Tinea Unguium

Categories: Infectious diseases, Skin diseases

Aliases & Classifications for Tinea Unguium

MalaCards integrated aliases for Tinea Unguium:

Name: Tinea Unguium 12 15 73
Cellulitis and Abscess of Upper Arm and Forearm 12
Cellulitis and Abscess of Finger and Toe 12
Cellulitis and Abscess of Gluteal Region 12
Cellulitis and Abscess of Buttock 12
Onychomycosis Due to Dermatophyte 12
Cellulitis and Abscess of Finger 12
Cellulitis and Abscess of Trunk 12
Cellulitis and Abscess of Face 12
Dermatophytic Onychomycosis 12
Dermatophytosis of Nail 12
Cellulitis and Abscess 12
Dermatophytic Onychia 12
Onychomycosis 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13074
ICD9CM 35 681.9
ICD10 33 B35.1

Summaries for Tinea Unguium

Disease Ontology : 12 A dermatophytosis that results in fungal infection located in nail, has material basis in Ascomycota fungi that belong to a group called dermatophytes, which cause separation of the nail plate from the nail bed and has symptom thickening of subungueal area. Sometimes, white islands are seen on the external nail plates. These gradually coalesce until the entire nail plate is involved.

MalaCards based summary : Tinea Unguium, also known as cellulitis and abscess of upper arm and forearm, is related to tinea pedis and uvulitis, and has symptoms including thickening of subungueal area An important gene associated with Tinea Unguium is GPT (Glutamic--Pyruvic Transaminase). The drugs Amorolfine and Ciclopirox have been mentioned in the context of this disorder. Affiliated tissues include nail and testes.

Related Diseases for Tinea Unguium

Diseases related to Tinea Unguium via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 18)
# Related Disease Score Top Affiliating Genes
1 tinea pedis 10.6
2 uvulitis 10.2
3 cellulitis 10.1
4 aging 10.0
5 erythema multiforme 10.0
6 tinea corporis 10.0
7 neuritis 10.0
8 tinea capitis 10.0
9 orbital cellulitis 10.0
10 dacryocystitis 9.9
11 acute dacryocystitis 9.7
12 central retinal artery occlusion 9.7
13 retinitis 9.7
14 retinal artery occlusion 9.7
15 impetigo 9.7
16 scleredema 9.7
17 pyridoxine deficiency 9.6 CBS GPT
18 tinea cruris 8.9 CBS PPIG

Graphical network of the top 20 diseases related to Tinea Unguium:



Diseases related to Tinea Unguium

Symptoms & Phenotypes for Tinea Unguium

Symptoms:

12
  • thickening of subungueal area

Drugs & Therapeutics for Tinea Unguium

Drugs for Tinea Unguium (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amorolfine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 78613-35-1
2
Ciclopirox Approved, Investigational Phase 4,Phase 3,Phase 2 29342-05-0 2749
3
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 22916-47-8 4189
4
Terbinafine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 91161-71-6 5402 1549008
5
Bifonazole Approved, Investigational Phase 4,Phase 3,Not Applicable 60628-96-8 2378
6
Itraconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Early Phase 1 84625-61-6 55283
7
Tavaborole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 174671-46-6
8
Efinaconazole Approved Phase 4,Phase 3,Not Applicable 164650-44-6
9 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
10 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
11 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
12 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
13 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
14 Dermatologic Agents Phase 4,Not Applicable
15 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
16 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
18 Keratolytic Agents Phase 4,Not Applicable
19 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
20 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
21
Hydroxyitraconazole Phase 4,Phase 3,Phase 2,Early Phase 1
22
Fluconazole Approved, Investigational Phase 3 86386-73-4 3365
23
Econazole Approved Phase 2 27220-47-9 3198
24
Naftifine Approved Phase 2 65472-88-0 73342 47641
25
Posaconazole Approved, Investigational, Vet_approved Phase 2,Not Applicable 171228-49-2 147912
26
Aminolevulinic acid Approved Phase 2,Not Applicable 106-60-5 137
27 Antiparasitic Agents Phase 2,Not Applicable
28 Antiprotozoal Agents Phase 2,Not Applicable
29
Ketoconazole Approved, Investigational Phase 1 65277-42-1 47576 3823
30 Tin Fluorides Phase 1
31
Tea tree oil Approved Not Applicable
32
Menthol Approved ,Not Applicable 2216-51-5 16666
33
Voriconazole Approved, Investigational Not Applicable 137234-62-9 71616
34
Petrolatum Approved, Investigational Early Phase 1 8009-03-8
35
Methylene blue Approved, Investigational Not Applicable 61-73-4
36 Anti-Bacterial Agents Not Applicable
37 Photosensitizing Agents Not Applicable
38 English Lavender Nutraceutical Not Applicable
39 Tea Nutraceutical Not Applicable
40 Tea Tree Nutraceutical Not Applicable

Interventional clinical trials:

(show top 50) (show all 118)
# Name Status NCT ID Phase Drugs
1 Efficacy, Safety and Cost-effectiveness of a Sequential Therapy With RV4104A Ointment, Ciclopiroxolamine Cream and Ciclopirox Film-forming Solution Compared With Amorolfine Nail Lacquer in Dermatophytic Onychomycosis Unknown status NCT01014637 Phase 4 Amorolfine (Antifungal);RV4104A, Ciclopiroxolamine, Cyclopirox (Keratolytic Agents/Antifungal)
2 Evaluation of the Efficacy of CURE-EX Treatment in Onychomycosis Unknown status NCT02436291 Phase 4
3 A Pilot Study - Safety and Efficacy of Nailprotex® for Onychomycosis Treatment Completed NCT02464826 Phase 4 Nailprotex
4 Resin vs. Amorolfine vs. Terbinafine Treatment in Onychomycosis Completed NCT01851590 Phase 4 Amorolfine;Terbinafine
5 Scoring Clinical Index For Onychomycosis in Toenail Onychomycosis Treating With Itraconazole Capsules Completed NCT00871728 Phase 4 Itraconazole
6 Topical Penlac Nail Lacquer for Onychomycosis in Children Completed NCT01419847 Phase 4 Ciclopirox;Placebo
7 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus Ciclopirox Nail Lacquer Completed NCT02679911 Phase 4 Loceryl Nail Lacquer;Ciclopirox Nail Lacquer
8 Treatment of Onychomycosis With Loceryl (Amorolfine) Nail Lacquer 5% Versus a Two-course Treatment With Urea 40% Ointment and Bifonazole Cream 1% Completed NCT02705664 Phase 4 Loceryl Nail Lacquer;Urea Ointment;Bifonazole Cream
9 An Evaluation of the Safety and Pharmacokinetics of Tavaborole Topical Solution for the Treatment of Fungal Disease of the Toenail in Children and Adolescents Completed NCT03405818 Phase 4 Tavaborole 5% Topical Solution
10 Antifungal Activity of Loceryl Nail Lacquer in Combination With a Cosmetic Varnish Completed NCT02321098 Phase 4 Loceryl Nail Lacquer;Loceryl Nail Lacquer;Loceryl Nail Lacquer follow up period
11 Comparison Between Long-pulsed Nd:YAG, Amorolfine and Combination Treatment in Treating Non-dermatophyte Onychomycosis Recruiting NCT02812043 Phase 4 Amorolfine
12 Phase IV Clinical Trial to Evaluate the Efficacy and Safety of Jublia® in Mild to Moderate Toenail Onychomycosis Recruiting NCT03280927 Phase 4 Jublia®
13 Safety and Pharmacokinetics of Efinaconazole Topical Solution in Subjects With Mild to Severe Onychomycosis Active, not recruiting NCT02812771 Phase 4 Efinaconazole
14 Evaluating the Efficacy and Compatibility of Efinaconazole 10% Solution (Jublia) for the Treatment of Toenail Onychomycosis in Patients Wearing Toenail Polish Compared to Those Without Polish Active, not recruiting NCT03110029 Phase 4 Efinaconazole 10% (Jublia)
15 Study Evaluating the Effect of Jublia on Dermatophytomas Active, not recruiting NCT03098615 Phase 4 Jublia (Efinaconazole 10% Topical Solution)
16 TDT 067 Onychomycosis Study Unknown status NCT01145807 Phase 3 TDT067;Placebo;Transfersome
17 Treating Onychomychosis Unknown status NCT00776464 Phase 2, Phase 3
18 Efficacy and Safety of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01302119 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
19 Efficacy and Safety Evaluation of AN2690 Topical Solution to Treat Onychomycosis of the Toenail Completed NCT01270971 Phase 3 AN2690 Topical Solution, 5%;Solution Vehicle
20 Itraconazole Tablets Vs. Itraconazole Capsules vs. Placebo in Onychomycosis of the Toenail. Completed NCT00356915 Phase 3 Itraconazole 100mg capsules;Itraconazole 200mg tablets;Placebo tablets
21 Clinical Trial on Onychomycosis With P-3058 Nail Solution in Pediatric Population Completed NCT02547701 Phase 3 P-3058
22 Safety and Efficacy of Luliconazole Solution, 10% in Subjects With Mild to Moderate Onychomycosis Completed NCT01431820 Phase 2, Phase 3 Luliconazole Solution, 10%;Vehicle Solution
23 Efficacy, Safety and Tolerability of Topical 10% Terbinafine Hydrogen Chloride Versus 5% Amorolfine Nail Lacquer in Patients With Mild to Moderate Toenail Onychomycosis Completed NCT00459537 Phase 3 terbinafine hydrogen chloride;amorolfine nail lacquer
24 PinPointe FootLaser for the Treatment of Onychomycosis Completed NCT00935649 Phase 2, Phase 3
25 Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01008033 Phase 3 IDP-108;Vehicle
26 The Safety and Efficacy of Topical IDP-108 Versus Vehicle in Patients With Onychomycosis Completed NCT01007708 Phase 3 IDP-108;Vehicle
27 Efficacy Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443820 Phase 3 terbinafine;Placebo;terbinafine;Placebo
28 Efficacy, Safety, and Tolerability of Topical Terbinafine in Patients With Mild to Moderate Toenail Fungus of the Big Toenail Completed NCT00443898 Phase 3 terbinafine;Placebo;terbinafine;Placebo
29 Comparative Efficacy of Bifonazole Cream vs Placebo After Nail Ablation With Urea Paste Completed NCT00781820 Phase 3 Bifonazole cream 1%;Placebo cream
30 Efficacy and Safety of Efinaconazole 10% Solution in the Treatment of Onychomycosis in Diabetic Patients Recruiting NCT03168841 Phase 3 Efinaconazole Topical
31 Study to Evaluate the Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO) Recruiting NCT02866032 Phase 3 MOB015B;Ciclopirox 80 mg/g
32 A Multi-centre, Double-blind, Randomized, Vehicle-controlled Study of Efficacy and Safety of Topical MOB015B in the Treatment of Mild to Moderate Distal Subungual Onychomycosis (DSO) Recruiting NCT02859519 Phase 3 MOB015B;MOB015B Vehicle
33 Study to Evaluate the Efficacy and Safety of P-3058 10% Nail Solution in the Treatment of Toenail Onychomycosis Active, not recruiting NCT02549001 Phase 3 P-3058 10%;vehicle of P-3058 10%;amorolfine 5%
34 Study Efficacy and Safety in Comparative Use of Investigational Product Adjuvant Treatment in Onychomycosis Not yet recruiting NCT02961634 Phase 3 Ciclopirox 8%
35 Antifungal Drugs in Treatment of Onychomycosis Not yet recruiting NCT03171584 Phase 3 Terbinafine
36 Safety & Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails Terminated NCT01208168 Phase 3 NAB001;Vehicle alone
37 Safety and Efficacy of NAB001 in the Treatment of Mild to Moderate Onychomycosis of the Toenails Terminated NCT01208129 Phase 3 NAB001;Placebo control
38 Study to Evaluate the Efficacy and Safety of P-3058 Nail Solution in the Treatment of Onychomycosis Withdrawn NCT03094468 Phase 3 P-3058 (terbinafine hydrochloride 10%);Vehicle of P-3058
39 Using Light Therapy to Treat Toe Nail Fungus Unknown status NCT00771732 Phase 2
40 Erbium-doped Yttrium Aluminium Garnet Laser(Er:Yag)Associated With Amorolfine Lacquer in the Treatment of Onychomycosis Unknown status NCT01528813 Phase 2 Amorolfine lacquer
41 A Trial of the Safety and Efficacy of EcoNail™ in the Treatment of Fungus Infections of the Great Toenail Unknown status NCT00385502 Phase 2 EcoNail™ (econazole 5%/SEPA® 18% nail lacquer)
42 Topical Gel Anti-Fungal Agent for Tinea Unguium Completed NCT00253305 Phase 2 Organogel of naftifine, 2%;Organogel of terbinafine, 2%;Organogel of naftifine, 6%;Organogel of terbinafine, 6%
43 Safety & Efficacy Study of HTU-520 in the Treatment of Distal Subungual Onychomycosis of the Toenail Completed NCT01400594 Phase 2 HTU-520 Patch
44 A Study to Evaluate Efficacy and Safety of Four Posaconazole Regimens With Placebo and Terbinafine in the Treatment of Toenail Onychomycosis (Study P05082AM2)(COMPLETED) Completed NCT00491764 Phase 2 SCH 56592;SCH 56592;SCH 56592;SCH 56592;Terbinafine;Placebo
45 A Study to Evaluate the Efficacy and Safety of Oral VT-1161 in Patients With Onychomycosis of the Toenail Completed NCT02267356 Phase 2 VT-1161;Placebo
46 Study of Different Doses of a Novel Treatment for Onychomycosis Completed NCT00679965 Phase 2 AN2690, 2.5%;AN2690, 5%;AN2690, 7.5%;AN2690 Solution Vehicle
47 Study of Different Doses of a Novel Treatment for Onychomycosis Completed NCT00679770 Phase 2 AN2690, 2.5%;AN2690, 5%;AN2690, 7.5%;Vehicle
48 Efficacy and Safety Study of Iontophoretic Application of Terbinafine Gel in Subjects With Onychomycosis Completed NCT01080079 Phase 2 Terbinafine Hydrochloride
49 Efficacy and Safety of Two Treatment Regimens of Topical MOB015 in Adults With Distal Subungual Onychomycosis Completed NCT01246518 Phase 2 MOB015
50 Evaluation of the Suitability of PD P 506 A in the PDT of Distal Subungual Onychomycosis (DSO) of the Great Toenail. Completed NCT02355899 Phase 2 PD P 506 A

Search NIH Clinical Center for Tinea Unguium

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Tinea Unguium

Anatomical Context for Tinea Unguium

The Foundational Model of Anatomy Ontology organs/tissues related to Tinea Unguium:

19
Nail

MalaCards organs/tissues related to Tinea Unguium:

41
Testes

Publications for Tinea Unguium

Articles related to Tinea Unguium:

(show top 50) (show all 52)
# Title Authors Year
1
Response to: Comment on "Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia". ( 29951161 )
2018
2
Tinea unguium onychomycosis caused by dermatophytes: a ten-year retrospective study (2005-2014) in a tertiary hospital in Singapore. ( 29552686 )
2018
3
Comment on "Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia". ( 29849837 )
2018
4
Prevalence, Etiology, and Risk Factors of Tinea Pedis and Tinea Unguium in Tunisia. ( 28852411 )
2017
5
Pathogenic Dermatophytes Survive in Nail Lesions During Oral Terbinafine Treatment for Tinea Unguium. ( 28281037 )
2017
6
Examining the accuracy of visual diagnosis of tinea pedis and tinea unguium in aged care facilities. ( 28379097 )
2017
7
Tinea Unguium: Diagnosis and Treatment in Practice. ( 27787643 )
2016
8
Clinical study of Dermatophyte Test Strip, an immunochromatographic method, to detect tinea unguium dermatophytes. ( 26992478 )
2016
9
Is the Dermatophyte Test Strip truly useful for the diagnosis of tinea unguium? Inquiry into "Clinical study of Dermatophyte Test Strip, an immunochromatographic method, to detect tinea unguium dermatophytes". ( 27910169 )
2016
10
Diagnostic accuracy of tinea unguium based on clinical observation. ( 25545551 )
2015
11
Screening for tinea unguium by thermography in older adults with subungual hyperkeratosis. ( 25311983 )
2014
12
Candida galli as a cause of tinea unguium-molecular characterization of a rare clinical fungal entity. ( 25037486 )
2014
13
A retrospective cohort study of tinea pedis and tinea unguium in inpatients in a psychiatric hospital. ( 24943206 )
2014
14
Screening for Tinea Unguium by Dermatophyte Test Strip. ( 24117339 )
2013
15
Rapid real-time diagnostic PCR for Trichophyton rubrum and Trichophyton mentagrophytes in patients with tinea unguium and tinea pedis using specific fluorescent probes. ( 23287391 )
2013
16
Disseminated erythema multiforme-like reaction triggered by tinea unguium. ( 21554422 )
2011
17
Optimized 5-hour multiplex PCR test for the detection of tinea unguium: performance in a routine PCR laboratory. ( 20105101 )
2010
18
Commentary: the illusory tinea unguium cure. ( 20159309 )
2010
19
Preventing long term relapsing tinea unguium with topical anti-fungal cream: a case report. ( 19154619 )
2009
20
Prevalence of tinea pedis, tinea unguium of toenails and tinea capitis in school children from Barcelona. ( 19766517 )
2009
21
Itraconazole concentrations of fingernails and toenails of patients with tinea unguium. ( 18477237 )
2008
22
In vitro antifungal susceptibility patterns of dermatophyte strains causing tinea unguium. ( 17714532 )
2007
23
Tinea pedis and tinea unguium in a 7-year-old child. ( 17644724 )
2007
24
Tinea unguium in the north-west of Iran (1996-2004). ( 17604428 )
2007
25
Twelve cases of tinea unguium in a pediatric clinic in 9 years. ( 17123110 )
2007
26
Epidemiology of tinea pedis and toenail tinea unguium in worshippers in the mosques in Adana, Turkey. ( 16361711 )
2005
27
Clinical and mycological study of occult tinea pedis and tinea unguium in dermatological patients from Tokyo. ( 12870199 )
2003
28
Experimental tinea unguium model to assess topical antifungal agents using the infected human nail with dermatophyte in vitro. ( 12525893 )
2002
29
Therapeutic efficacy of topically applied KP-103 against experimental tinea unguium in guinea pigs in comparison with amorolfine and terbinafine. ( 12435679 )
2002
30
Smear positive leprosy with HIV infection, silent neuritis and extensive tinea corporis and tinea unguium in an Indian male. ( 11898467 )
2001
31
Tinea unguium in Lahore, Pakistan. ( 11346265 )
2001
32
Interferon-gamma production in peripheral lymphocytes of patients with tinea pedis: comparison of patients with and without tinea unguium. ( 11270412 )
2001
33
Prevalence and risk factors of tinea unguium and tinea pedis in the general population in Spain. ( 10970362 )
2000
34
Current topics in diagnosis and treatment of tinea unguium in Japan. ( 10091478 )
1999
35
A review of the epidemiology of tinea unguium in the community. ( 10098282 )
1999
36
Evaluation of 6 weeks treatment of terbinafine in tinea unguium in a double-blind trial comparing 6 and 12 weeks therapy. The Lagos V Study Group. ( 9205509 )
1997
37
Results of German multicenter study of antimicrobial susceptibilities of Trichophyton rubrum and Trichophyton mentagrophytes strains causing tinea unguium. German Collaborative Dermatophyte Drug Susceptibility Study Group. ( 7625820 )
1995
38
The proteolytic activity of strains of T. mentagrophytes and T. rubrum isolated from tinea pedis and tinea unguium infections. ( 7666296 )
1995
39
Short therapy for tinea unguium with terbinafine: four different courses of treatment. ( 8531933 )
1995
40
Clinical and pharmacokinetic investigations of oral terbinafine in patients with tinea unguium. ( 7477090 )
1995
41
Treatment of tinea unguium with medium and high doses of ultramicrosize griseofulvin compared with that with itraconazole. ( 8257124 )
1993
42
KONCPA: a new method for diagnosing tinea unguium. ( 8219416 )
1993
43
Is tinea unguium still widely incurable? A review three decades after the introduction of griseofulvin. ( 1531407 )
1992
44
Aetiology of onychomycosis and tinea unguium. ( 2530843 )
1989
45
A modified method to detect dermatophytes in the diagnosis of tinea unguium. ( 2961845 )
1987
46
A modified method for rapid mycological diagnosis of Tinea unguium in Taiwan, Republic of China. ( 2954779 )
1987
47
Tinea unguium. ( 2960495 )
1987
48
Urea plaster for softening diseased nails in the treatment of tinea unguium. ( 2962190 )
1986
49
Tinea unguium. ( 2946867 )
1986
50
Dermatophytic agents of tinea unguium in Iran. ( 4270580 )
1973

Variations for Tinea Unguium

Expression for Tinea Unguium

Search GEO for disease gene expression data for Tinea Unguium.

Pathways for Tinea Unguium

GO Terms for Tinea Unguium

Biological processes related to Tinea Unguium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular amino acid biosynthetic process GO:0008652 8.62 CBS GPT

Molecular functions related to Tinea Unguium according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 single-stranded DNA binding GO:0003697 8.96 CNBP SUB1
2 pyridoxal phosphate binding GO:0030170 8.62 CBS GPT

Sources for Tinea Unguium

3 CDC
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34 ICD10 via Orphanet
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
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71 TGDB
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74 UMLS via Orphanet
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