TLA
MCID: TLN014
MIFTS: 19

Tl Antigen (TLA)

Categories: Cancer diseases, Eye diseases, Immune diseases

Aliases & Classifications for Tl Antigen

MalaCards integrated aliases for Tl Antigen:

Name: Tl Antigen 57
Histocompatibility 2, T-Region Locus 18; H2-T18 57
Histocompatibility 2, T-Region Locus 18 57
Thymus Leukemia Antigen; Tla 57
Thymus Leukemia Antigen 57
H2-T18 57
Tla 57

Classifications:



External Ids:

OMIM® 57 188850

Summaries for Tl Antigen

MalaCards based summary : Tl Antigen, also known as histocompatibility 2, t-region locus 18; h2-t18, is related to leukemia and asthma. An important gene associated with Tl Antigen is RAD21 (RAD21 Cohesin Complex Component). Affiliated tissues include thymus, eye and t cells.

More information from OMIM: 188850

Related Diseases for Tl Antigen

Diseases in the Tl Antigen family:

Xh Antigen Hr44 Antigen

Diseases related to Tl Antigen via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 leukemia 10.1
2 asthma 10.0
3 allergic asthma 10.0
4 inflammatory bowel disease 10.0
5 acute leukemia 10.0
6 herpes simplex 10.0
7 precursor t-cell acute lymphoblastic leukemia 10.0
8 inguinal hernia 9.9
9 urinary tract infection 9.9
10 chronic asthma 9.9
11 allergic disease 9.9
12 acute cystitis 9.9
13 vascular disease 9.9
14 teratocarcinoma 9.9
15 embryonal carcinoma 9.9
16 thymus lymphoma 9.9

Graphical network of the top 20 diseases related to Tl Antigen:



Diseases related to Tl Antigen

Symptoms & Phenotypes for Tl Antigen

Clinical features from OMIM®:

188850 (Updated 20-May-2021)

Drugs & Therapeutics for Tl Antigen

Search Clinical Trials , NIH Clinical Center for Tl Antigen

Genetic Tests for Tl Antigen

Anatomical Context for Tl Antigen

MalaCards organs/tissues related to Tl Antigen:

40
Thymus, Eye, T Cells, Bone Marrow, Skin, Bone

Publications for Tl Antigen

Articles related to Tl Antigen:

(show top 50) (show all 79)
# Title Authors PMID Year
1
Molecular basis for the high affinity interaction between the thymic leukemia antigen and the CD8alphaalpha molecule. 57
15749886 2005
2
T cell responses modulated through interaction between CD8alphaalpha and the nonclassical MHC class I molecule, TL. 57
11729321 2001
3
Biochemical genetics of TL antigens. 57
2427440 1986
4
CD8αα Expression Marks Terminally Differentiated Human CD8+ T Cells Expanded in Chronic Viral Infection. 61
23964274 2013
5
Crosstalk between adaptive and innate immune cells leads to high quality immune protection at the mucosal borders. 61
23456836 2013
6
TL and CD8αα: Enigmatic partners in mucosal immunity. 61
20850477 2010
7
Thymus leukemia antigen controls intraepithelial lymphocyte function and inflammatory bowel disease. 61
19004778 2008
8
SOCS1 downregulation in dendritic cells promotes memory T-cell responses. 61
18222020 2008
9
Splenic gammadelta T cells regulated by CD4+ T cells are required to control chronic Plasmodium chabaudi malaria in the B-cell-deficient mouse. 61
16622208 2006
10
CD8: adhesion molecule, co-receptor and immuno-modulator. 61
16212893 2004
11
The crystal structure of a TL/CD8alphaalpha complex at 2.1 A resolution: implications for modulation of T cell activation and memory. 61
12594948 2003
12
The binding of thymus leukemia (TL) antigen tetramers to normal intestinal intraepithelial lymphocytes and thymocytes. 61
11441080 2001
13
Migration and differentiation of autoreactive B-1 cells induced by activated gamma/delta T cells in antierythrocyte immunoglobulin transgenic mice. 61
11104800 2000
14
The epitope detected by cytotoxic T lymphocytes against thymus leukemia (TL) antigen is TAP independent. 61
10967016 2000
15
Comparison of anti-tumor responses against TL positive lymphoma induced by skin grafting and dendritic cell immunization. 61
10981835 2000
16
TL antigen is not linked to radioinduced thymic lymphoma. 61
9630842 1998
17
Characterization of CD4+CD8+ thymocytes observed in SCID-bg mice. 61
9429895 1997
18
Requirement of CD4 T cells for skin graft rejection against thymus leukemia (TL) antigen and multiple epitopes on the TL molecule recognized by CD4 T cells. 61
9200451 1997
19
Positive selection of gamma delta CTL by TL antigen expressed in the thymus. 61
8976173 1996
20
Antigen-presenting function of the TL antigen and mouse CD1 molecules. 61
8847078 1995
21
A novel T-cell differentiation antigen expressed in immature human thymocytes and neuroglial cells. 61
7545548 1995
22
Nonclassical behavior of the thymus leukemia antigen: peptide transporter-independent expression of a nonclassical class I molecule. 61
7699328 1995
23
Thymus-leukaemia antigens: the haemochromatosis gene product? 61
7835988 1994
24
TL antigen as a transplantation antigen recognized by TL-restricted cytotoxic T cells. 61
8113675 1994
25
Structure and function of H-2 T (Tla) region class I MHC molecules. 61
7741975 1994
26
Regulation of TL antigen expression. Analysis of the T18d promoter region and responses to IFN-gamma. 61
8360484 1993
27
Differential induction of major histocompatibility complex molecules on mouse intestine by bacterial colonization. 61
1451971 1992
28
Expression of mouse Tla region class I genes in tissues enriched for gamma delta cells. 61
1388139 1992
29
The thymus leukemia antigen binds human and mouse CD8. 61
1834760 1991
30
Abnormal thymic development, impaired immune function and gamma delta T cell lymphomas in a TL transgenic mouse strain. 61
1713249 1991
31
Highly restricted expression of the thymus leukemia antigens on intestinal epithelial cells. 61
1711563 1991
32
Cellular location of thymus-leukemia (TL) antigen as shown by immuno-cryoultramicrotomy. 61
1885998 1991
33
Recognition of MHC TL gene products by gamma delta T cells. 61
1830863 1991
34
Expression of the thymus leukemia antigen in mouse intestinal epithelium. 61
2263622 1990
35
HLA non-A,B,C class I genes: their structure and expression. 61
2089074 1990
36
Expression of TL, H-2, and chimeric H-2/TL genes in transgenic mice: abnormal thymic differentiation and T-cell lymphomas in a TL transgenic strain. 61
2813374 1989
37
DNA sequence of a class I pseudogene from the Tla region of the murine MHC: recombination at a B2 alu repetitive sequence. 61
2543831 1989
38
The RT1.G locus in the rat encodes a Qa/TL-like antigen. 61
2570748 1989
39
Influence of 5' flanking sequences on TL and H-2 expression in transfected L cells. 61
3368465 1988
40
Genomic organization of the mouse Tla locus: study of an endogenous retroviruslike locus reveals polymorphisms related to different Tla haplotypes. 61
2901400 1988
41
Proliferative kinetics, phenotype and cytotoxic function of thymic and peripheral T-cell colonies. 61
3082000 1986
42
A mutational hot-spot within an intron of the mouse beta 2-microglobulin gene. 61
3514206 1986
43
Intron sequences reveal evolutionary relationships among major histocompatibility complex class I genes. 61
3862103 1985
44
Structure of a gene encoding a murine thymus leukemia antigen, and organization of Tla genes in the BALB/c mouse. 61
3894562 1985
45
Differentiation of thymocytes in fetal organ culture: analysis of phenotypic changes accompanying the appearance of cytolytic and interleukin 2-producing cells. 61
6611365 1984
46
Age-related expression of TL antigen in AKR/J mice. 61
6746114 1984
47
Cellular immunology in the baboon (Papio cynocephalus): examination of structural and functional characteristics of adult and fetal lymphoid cells. 61
6084035 1984
48
Identification and characterization of a human thymus-leukemia antigen (43-kDa/513TL) bearing a structural relationship to HLA. 61
6332239 1984
49
Structural identity of the TL antigen homologues derived from strain 2 and strain 13 guinea pigs. 61
6604095 1983
50
Antigens specified by the Tla locus are expressed on the surface of murine Langerhans cells. 61
6345683 1983

Variations for Tl Antigen

Expression for Tl Antigen

Search GEO for disease gene expression data for Tl Antigen.

Pathways for Tl Antigen

GO Terms for Tl Antigen

Sources for Tl Antigen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
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20 GARD
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31 HPO
32 ICD10
33 ICD10 via Orphanet
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44 MeSH
45 MESH via Orphanet
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49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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