TLA
MCID: TLN014
MIFTS: 17

Tl Antigen (TLA)

Categories: Cancer diseases

Aliases & Classifications for Tl Antigen

MalaCards integrated aliases for Tl Antigen:

Name: Tl Antigen 57
Histocompatibility 2, T-Region Locus 18; H2-T18 57
Histocompatibility 2, T-Region Locus 18 57
Thymus Leukemia Antigen; Tla 57
Thymus Leukemia Antigen 57
H2-T18 57
Tla 57

Classifications:



External Ids:

OMIM 57 188850

Summaries for Tl Antigen

MalaCards based summary : Tl Antigen, also known as histocompatibility 2, t-region locus 18; h2-t18, is related to leukemia and asthma. An important gene associated with Tl Antigen is RAD21 (RAD21 Cohesin Complex Component). Affiliated tissues include thymus, t cells and skin.

Description from OMIM: 188850

Related Diseases for Tl Antigen

Diseases in the Tl Antigen family:

Xh Antigen

Diseases related to Tl Antigen via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leukemia 10.1
2 asthma 10.0
3 dermatitis 10.0
4 embryonal carcinoma 10.0
5 allergic asthma 10.0
6 lymphoma 9.9

Graphical network of the top 20 diseases related to Tl Antigen:



Diseases related to Tl Antigen

Symptoms & Phenotypes for Tl Antigen

Clinical features from OMIM:

188850

Drugs & Therapeutics for Tl Antigen

Search Clinical Trials , NIH Clinical Center for Tl Antigen

Genetic Tests for Tl Antigen

Anatomical Context for Tl Antigen

MalaCards organs/tissues related to Tl Antigen:

41
Thymus, T Cells, Skin

Publications for Tl Antigen

Articles related to Tl Antigen:

(show all 17)
# Title Authors Year
1
The binding of thymus leukemia (TL) antigen tetramers to normal intestinal intraepithelial lymphocytes and thymocytes. ( 11441080 )
2001
2
The epitope detected by cytotoxic T lymphocytes against thymus leukemia (TL) antigen is TAP independent. ( 10967016 )
2000
3
TL antigen is not linked to radioinduced thymic lymphoma. ( 9630842 )
1998
4
Requirement of CD4 T cells for skin graft rejection against thymus leukemia (TL) antigen and multiple epitopes on the TL molecule recognized by CD4 T cells. ( 9200451 )
1997
5
Positive selection of gamma delta CTL by TL antigen expressed in the thymus. ( 8976173 )
1996
6
Antigen-presenting function of the TL antigen and mouse CD1 molecules. ( 8847078 )
1995
7
Nonclassical behavior of the thymus leukemia antigen: peptide transporter-independent expression of a nonclassical class I molecule. ( 7699328 )
1995
8
TL antigen as a transplantation antigen recognized by TL-restricted cytotoxic T cells. ( 8113675 )
1994
9
Regulation of TL antigen expression. Analysis of the T18d promoter region and responses to IFN-gamma. ( 8360484 )
1993
10
Cellular location of thymus-leukemia (TL) antigen as shown by immuno-cryoultramicrotomy. ( 1885998 )
1991
11
Age-related expression of TL antigen in AKR/J mice. ( 6746114 )
1984
12
Structural identity of the TL antigen homologues derived from strain 2 and strain 13 guinea pigs. ( 6604095 )
1983
13
Structural evidence that the small subunit found associated with the TL antigen is beta 2-microglobulin. ( 6179864 )
1982
14
Subfragments of the papain solubilized TL antigen. ( 1176764 )
1975
15
Antigenic modulation in vitro. I. Fate of thymus-leukemia (TL) antigen-antibody complexes following modulation of TL antigenicity from the surfaces of mouse leukemia cells and thymocytes. ( 4610077 )
1974
16
Differentiation of the thymus-leukemia (TL) antigen in the thymus of mouse embryos. ( 5728807 )
1968
17
Antigenic modulation. Loss of TL antigen from cells exposed to TL antibody. Study of the phenomenon in vitro. ( 5636556 )
1968

Variations for Tl Antigen

Expression for Tl Antigen

Search GEO for disease gene expression data for Tl Antigen.

Pathways for Tl Antigen

GO Terms for Tl Antigen

Sources for Tl Antigen

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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