THS
MCID: TLS001
MIFTS: 34

Tolosa-Hunt Syndrome (THS)

Categories: Eye diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Tolosa-Hunt Syndrome

MalaCards integrated aliases for Tolosa-Hunt Syndrome:

Name: Tolosa-Hunt Syndrome 12 73 20 58 44 15 70
Painful Ophthalmoplegia 20 58
Nonspecific Inflammation of the Cavernous Sinus or Superior Orbital Fissure 20
Ophthalmoplegia, Painful 70
Tolosa Hunt Syndrome 20
Ths 20

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:1278
MeSH 44 D020333
NCIt 50 C85193
SNOMED-CT 67 75111000
MESH via Orphanet 45 C531833 D020333
ICD10 via Orphanet 33 H49.8
UMLS via Orphanet 71 C0040381 C0392060
Orphanet 58 ORPHA64686
UMLS 70 C0040381 C0392060

Summaries for Tolosa-Hunt Syndrome

GARD : 20 Tolosa Hunt syndrome (THS) is a rare condition characterized by painful ophthalmoplegia (paralysis and/or weakness of the eye muscles). Onset can occur at any age. Signs and symptoms include a constant pain behind the eye; decreased eye movements; and signs of cranial nerve paralysis such as drooping of the upper eyelid ( ptosis ), double vision (diplopia), large pupil, and facial numbness. Although it is considered a benign condition, permanent neurologic deficits can occur and relapses are common. The features of THS are caused by inflammation of the cavernous sinus (an area at the base of the brain) but the underlying cause of the inflammation is unknown. Left untreated, symptoms may resolve spontaneously after an average of about eight weeks. Treatment may include use of glucocorticoids or other immunosuppressive therapies.

MalaCards based summary : Tolosa-Hunt Syndrome, also known as painful ophthalmoplegia, is related to cranial nerve palsy and facial paralysis, and has symptoms including ophthalmoplegia An important gene associated with Tolosa-Hunt Syndrome is PRTN3 (Proteinase 3). Affiliated tissues include eye, pituitary and brain.

Wikipedia : 73 Tolosa-Hunt syndrome (THS) is a rare disorder characterized by severe and unilateral headaches with... more...

Related Diseases for Tolosa-Hunt Syndrome

Diseases related to Tolosa-Hunt Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 369)
# Related Disease Score Top Affiliating Genes
1 cranial nerve palsy 30.8 PRTN3 CRP ACE
2 facial paralysis 30.7 PRTN3 CRP ACE
3 exophthalmos 30.5 CD1E CD1A
4 multiple cranial nerve palsy 30.5 PRTN3 CRP ACE
5 orbital plasma cell granuloma 30.5 PRTN3 CRP
6 mononeuropathy 30.4 PRTN3 CRP
7 pyelonephritis 30.4 CRP ACE
8 papilledema 30.4 CRP ACE
9 scleritis 30.2 PRTN3 CRP
10 neurosarcoidosis 30.1 CRP ACE
11 carotid stenosis 30.1 CRP ACE
12 coronary heart disease 1 30.0 CRP ACE
13 posterior scleritis 29.9 PRTN3 CRP ACE
14 sphenoid sinusitis 29.9 CRP CD1E CD1A
15 exanthem 29.9 PRTN3 CRP ACE
16 pulmonary disease, chronic obstructive 29.8 PRTN3 CRP ACE
17 kearns-sayre syndrome 11.1
18 acute ackee fruit intoxication 10.9
19 ptosis 10.8
20 headache 10.7
21 meningioma, familial 10.6
22 intracranial meningioma 10.6
23 secretory meningioma 10.6
24 lymphoplasmacyte-rich meningioma 10.6
25 sarcoidosis 1 10.5
26 migraine with or without aura 1 10.5
27 aneurysm 10.5
28 abducens palsy 10.4
29 b-cell lymphoma 10.4
30 neuropathy 10.4
31 diabetes insipidus 10.4
32 burkitt lymphoma 10.3
33 trigeminal neuralgia 10.3
34 bell's palsy 10.3
35 optic nerve disease 10.3
36 thyroiditis 10.3
37 actinomycosis 10.3
38 lupus erythematosus 10.3
39 granulomatous myositis 10.3 PRTN3 ACE
40 purulent acute otitis media 10.3 PRTN3 CRP
41 frontal sinusitis 10.3 PRTN3 CRP
42 bicipital tenosynovitis 10.3 PRTN3 CRP
43 tenosynovitis 10.3 PRTN3 CRP
44 ethmoid sinusitis 10.3 PRTN3 CRP
45 acute dacryoadenitis 10.2 CRP ACE
46 splenic tuberculosis 10.2 PRTN3 CRP
47 subacute bacterial endocarditis 10.2 PRTN3 CRP
48 mediastinum teratoma 10.2 CRP ACE
49 branch retinal artery occlusion 10.2 PRTN3 CRP
50 cardiac tuberculosis 10.2 CRP ACE

Graphical network of the top 20 diseases related to Tolosa-Hunt Syndrome:



Diseases related to Tolosa-Hunt Syndrome

Symptoms & Phenotypes for Tolosa-Hunt Syndrome

UMLS symptoms related to Tolosa-Hunt Syndrome:


ophthalmoplegia

Drugs & Therapeutics for Tolosa-Hunt Syndrome

Search Clinical Trials , NIH Clinical Center for Tolosa-Hunt Syndrome

Cochrane evidence based reviews: tolosa-hunt syndrome

Genetic Tests for Tolosa-Hunt Syndrome

Anatomical Context for Tolosa-Hunt Syndrome

MalaCards organs/tissues related to Tolosa-Hunt Syndrome:

40
Eye, Pituitary, Brain, Breast, Cortex, Heart, Smooth Muscle

Publications for Tolosa-Hunt Syndrome

Articles related to Tolosa-Hunt Syndrome:

(show top 50) (show all 596)
# Title Authors PMID Year
1
Tolosa-Hunt Syndrome as an Initial Presentation of Sarcoidosis. 61
31488356 2021
2
Tolosa-Hunt Syndrome in Childhood and Adolescence: A Literature Review in the Last 10 Years. 61
32892335 2021
3
Tolosa-Hunt syndrome as a manifestation of Hypertrophic Pachymeningitis. 61
32910772 2021
4
Tolosa-Hunt syndrome relapse during pregnancy following chronic intake of combined oral contraceptives. 61
33462037 2021
5
Tolosa-Hunt Syndrome Misdiagnosed as Surgical Complication After Frontal Balloon Sinuplasty. 61
33534326 2021
6
Painful ophthalmoplegia syndrome, beyond Tolosa-Hunt syndrome. A case series. 61
33384172 2020
7
Cavernous sinus lesions. 61
32574933 2020
8
Magnetic resonance imaging (MRI) versus computed tomographic scan (CT scan) of brain in evaluation of suspected cavernous sinus syndrome. 61
33283671 2020
9
Bilateral facial nerve involvement in a patient with Tolosa-Hunt syndrome. 61
32648510 2020
10
Escaping from the hunt. 61
33129799 2020
11
A rare case of pediatric Tolosa-Hunt syndrome. 61
32889049 2020
12
[Tolosa-Hunt Syndrome; clinical and brain MRI features and treatment]. 61
32789829 2020
13
Tolosa-Hunt syndrome: case series on the timed use of diagnostic magnetic resonance imaging. 61
32241528 2020
14
Treatment of idiopathic orbital myositis with frequent relapses: First case with tacrolimus and review of literature. 61
32668345 2020
15
Perineuritis or infiltration of optic nerve sheath? A presentation of diffuse large B cell Gastric lymphoma. 61
32461486 2020
16
Tolosa-Hunt syndrome with general myasthenia gravis involvement. 61
32706200 2020
17
Tolosa-Hunt Syndrome: A Non-Classical Presentation of a Rare Cause of Unilateral Headache and Painful Ophthalmoplegia. 61
32362975 2020
18
Use of methotrexate in the management of recurrent Tolosa-Hunt syndrome: Two case reports. 61
32332660 2020
19
TOLOSA-HUNT SYNDROME WITH PITUITARY INVOLVEMENT. 61
32160047 2020
20
Burkitt lymphoma masquerading as Tolosa-Hunt syndrome in an HIV-seropositive patient. 61
31018683 2020
21
Tolosa-Hunt Syndrome: Long-Term Outcome and Role of Steroid-Sparing Agents. 61
32189862 2020
22
Gone in the blink of an eye - A Tolosa-Hunt syndrome variant. 61
31879056 2020
23
A Case of Recurrent Painful Ophthalmoplegic Neuropathy with Associated Oculomotor Nerve Tumour. 61
32076446 2020
24
Tolosa-Hunt Syndrome: A Painful Ophthalmoplegia. 61
33204552 2020
25
Clinical Features of Painful Ophthalmoplegia with a High-Intensity Ring Appearance around the Optic Nerve on MRI: A Case Series. 61
32292612 2020
26
Reappraising the Tolosa-Hunt Syndrome Diagnostic Criteria: A Case Series. 61
31681980 2020
27
A Case of Tolosa-Hunt Syndrome With Discoid Lupus Erythematosus. 61
31839865 2020
28
Successful treatment of pediatric Tolosa-Hunt syndrome with adalimumab. 61
31804175 2019
29
Tolosa-Hunt Syndrome: Clinical Manifestations in Children. 61
30982655 2019
30
[Cavernous sinus syndrome as the initial symptom of Burkitt's lymphoma: a case report and literature review]. 61
31497869 2019
31
Optic Perineuritis in a Case of Tolosa-Hunt Syndrome. 61
31602155 2019
32
Endoscopic transnasal image-guided approach to diagnosis in orbital apex and optic canal lesions. 61
31271349 2019
33
The aetiologies of unilateral oculomotor nerve palsy: a clinical analysis on 121 patients. 61
31035834 2019
34
Clinical features of hypertrophic pachymeningitis in a center survey. 61
30588552 2019
35
Carotid-cavernous fistula(CCF) presenting as paroxysmal painful ophthalmoplegia. 61
30744702 2019
36
Oculomotor Synkinesis (Aberrant Reinnervation of the Third Cranial Nerve) Associated with Atypical Tolosa-Hunt Syndrome. 61
33012913 2019
37
A 17-Year-Old Girl With Unilateral Headache and Double Vision. 61
31010318 2019
38
Actinomyces cavernous sinus infection: a case and systematic literature review. 61
29650638 2018
39
Time to retire the Tolosa-Hunt syndrome? 61
29848513 2018
40
Miller Fisher Syndrome Mimicking Tolosa-Hunt Syndrome. 61
29709941 2018
41
A case of headache, double vision and ptosis in emergency department: Tolosa-Hunt syndrome. 61
30191197 2018
42
Tolosa-Hunt Syndrome: Appraising the ICHD-3 beta diagnostic criteria. 61
29169256 2018
43
The aetiologies of the unilateral oculomotor nerve palsy: a review of the literature. 61
30592440 2018
44
A cavernous sinus lesion clinically responsive to steroids. 61
29685413 2018
45
A case of delirium in Tolosa-Hunt syndrome during corticosteroid therapy. 61
32026006 2018
46
Angiographic Findings in the Tolosa-Hunt Syndrome and Resolution after Corticosteroid Treatment. 61
29796050 2018
47
Orbital Pain, Ophthalmoplegia, and Oligoclonal Bands in the Cerebrospinal Fluid: A Case Report of Tolosa-Hunt Syndrome. 61
29516491 2018
48
Tolosa-Hunt Syndrome. 61
29623162 2018
49
Painful Ophthalmoplegia: Aspergillosis, Tolosa-hunt and other Causes. 61
30039043 2018
50
Successful Treatment of Tolosa-Hunt Syndrome after a Single Infusion of Infliximab. 61
29629550 2018

Variations for Tolosa-Hunt Syndrome

Expression for Tolosa-Hunt Syndrome

Search GEO for disease gene expression data for Tolosa-Hunt Syndrome.

Pathways for Tolosa-Hunt Syndrome

GO Terms for Tolosa-Hunt Syndrome

Cellular components related to Tolosa-Hunt Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 PRTN3 CRP CD1E CD1A ACE

Biological processes related to Tolosa-Hunt Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell mediated cytotoxicity GO:0001916 9.16 CD1E CD1A
2 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 8.96 CD1E CD1A
3 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.62 CD1E CD1A

Molecular functions related to Tolosa-Hunt Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carboxypeptidase activity GO:0004180 9.32 CNDP2 ACE
2 lipopeptide binding GO:0071723 9.26 CD1E CD1A
3 metallodipeptidase activity GO:0070573 9.16 CNDP2 ACE
4 exogenous lipid antigen binding GO:0030884 8.96 CD1E CD1A
5 endogenous lipid antigen binding GO:0030883 8.62 CD1E CD1A

Sources for Tolosa-Hunt Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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