MCID: TLS001
MIFTS: 36

Tolosa-Hunt Syndrome

Categories: Rare diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Tolosa-Hunt Syndrome

MalaCards integrated aliases for Tolosa-Hunt Syndrome:

Name: Tolosa-Hunt Syndrome 12 53 59 44 15 73
Painful Ophthalmoplegia 53 59
Nonspecific Inflammation of the Cavernous Sinus or Superior Orbital Fissure 53
Ophthalmoplegia, Painful 73
Tolosa Hunt Syndrome 53
Ths 53

Classifications:

Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:1278
MeSH 44 D020333
NCIt 50 C85193
SNOMED-CT 68 75111000 95794005
Orphanet 59 ORPHA64686
ICD10 via Orphanet 34 H49.8
MESH via Orphanet 45 C531833 D020333
UMLS via Orphanet 74 C0040381 C0392060

Summaries for Tolosa-Hunt Syndrome

NIH Rare Diseases : 53 Tolosa Hunt syndrome (THS) is a rare condition characterized by painful ophthalmoplegia (paralysis and/or weakness of the eye muscles). Onset can occur at any age. Signs and symptoms include a constant pain behind the eye; decreased eye movements; and signs of cranial nerve paralysis such as drooping of the upper eyelid (ptosis), double vision (diplopia), large pupil, and facial numbness. Although it is considered a benign condition, permanent neurologic deficits can occur and relapses are common. The features of THS are caused by inflammation of the cavernous sinus (an area at the base of the brain) but the underlying cause of the inflammation is unknown. Left untreated, symptoms may resolve spontaneously after an average of about eight weeks. Treatment may include use of glucocorticoids or other immunosuppressive therapies.

MalaCards based summary : Tolosa-Hunt Syndrome, also known as painful ophthalmoplegia, is related to segawa syndrome, autosomal recessive and dystonia, dopa-responsive, and has symptoms including ophthalmoplegia An important gene associated with Tolosa-Hunt Syndrome is NT5C3A (5'-Nucleotidase, Cytosolic IIIA), and among its related pathways/superpathways is Aryl Hydrocarbon Receptor. Affiliated tissues include eye, brain and thyroid.

Wikipedia : 76 Tolosa–Hunt syndrome (THS) is a rare disorder characterized by severe and unilateral headaches with... more...

Related Diseases for Tolosa-Hunt Syndrome

Diseases related to Tolosa-Hunt Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 segawa syndrome, autosomal recessive 11.9
2 dystonia, dopa-responsive 11.5
3 tibial aplasia-ectrodactyly syndrome 10.9
4 hyperphenylalaninemia, bh4-deficient, a 10.9
5 allan-herndon-dudley syndrome 10.9
6 dopa-responsive dystonia; segawa syndrome ad 10.9
7 cerebral arterial disease 10.5 NF1 RPSA
8 schnitzler syndrome 10.5 CD40LG NLRP3
9 chronic polyneuropathy 10.5 CD40LG NF1
10 aneurysm 10.5
11 moyamoya disease 1 10.4 NF1 RPSA
12 cardiovascular syphilis 10.4 CD40LG SMUG1
13 conjunctival disease 10.4 CD40LG NLRP3
14 urachal adenocarcinoma 10.4 CEACAM5 NF1
15 brachial plexus lesion 10.4 NF1 NLRP3
16 plexopathy 10.4 NLRP3 SMUG1
17 lymphoma 10.4
18 non-secretory myeloma 10.4 CD40LG SMUG1
19 central nervous system vasculitis 10.3 CD40LG SMUG1
20 liver lymphoma 10.3 CEACAM5 SMUG1
21 splenic tuberculosis 10.3 CEACAM5 SMUG1
22 gallbladder squamous cell carcinoma 10.3 CEACAM5 SMUG1
23 malignant spiradenoma 10.3 CEACAM5 SMUG1
24 gastric signet ring cell adenocarcinoma 10.3 CEACAM5 SMUG1
25 eccrine adenocarcinoma 10.3 CEACAM5 SMUG1
26 lung lymphoma 10.2 CD40LG SMUG1
27 skeletal tuberculosis 10.2 NLRP3 SMUG1
28 femoral neuropathy 10.2 CEACAM5 SMUG1
29 exanthem 10.2 CD40LG NLRP3
30 sinusitis 10.2
31 thyroiditis 10.2
32 neuropathy 10.2
33 headache 10.2
34 descending colon cancer 10.2 CEACAM5 SMUG1
35 prostate squamous cell carcinoma 10.2 CEACAM5 SMUG1
36 tuberculous peritonitis 10.2 CEACAM5 SMUG1
37 xanthogranulomatous cholecystitis 10.1 CEACAM5 SMUG1
38 systemic lupus erythematosus 10.1
39 arteriovenous fistula 10.1
40 b-cell lymphomas 10.1
41 cerebritis 10.1
42 aortic aneurysm 10.1
43 actinomycosis 10.1
44 lupus erythematosus 10.1
45 hypopituitarism 10.1
46 diabetes insipidus 10.1
47 hypersensitivity reaction type iv disease 10.1 CD40LG SMUG1
48 cogan syndrome 10.0 CD40LG SMUG1
49 breast cancer 10.0
50 hashimoto thyroiditis 10.0

Graphical network of the top 20 diseases related to Tolosa-Hunt Syndrome:



Diseases related to Tolosa-Hunt Syndrome

Symptoms & Phenotypes for Tolosa-Hunt Syndrome

UMLS symptoms related to Tolosa-Hunt Syndrome:


ophthalmoplegia

Drugs & Therapeutics for Tolosa-Hunt Syndrome

Search Clinical Trials , NIH Clinical Center for Tolosa-Hunt Syndrome

Cochrane evidence based reviews: tolosa-hunt syndrome

Genetic Tests for Tolosa-Hunt Syndrome

Anatomical Context for Tolosa-Hunt Syndrome

MalaCards organs/tissues related to Tolosa-Hunt Syndrome:

41
Eye, Brain, Thyroid, Pituitary, B Cells, Neutrophil, Salivary Gland

Publications for Tolosa-Hunt Syndrome

Articles related to Tolosa-Hunt Syndrome:

(show top 50) (show all 210)
# Title Authors Year
1
Orbital Pain, Ophthalmoplegia, and Oligoclonal Bands in the Cerebrospinal Fluid: A Case Report of Tolosa-Hunt Syndrome. ( 29516491 )
2018
2
Tolosa-Hunt Syndrome. ( 29623162 )
2018
3
Angiographic Findings in the Tolosa-Hunt Syndrome and Resolution after Corticosteroid Treatment. ( 29796050 )
2018
4
A Case of Miller Fisher Syndrome Mimicking Tolosa-Hunt Syndrome. ( 29709941 )
2018
5
Time to retire the Tolosa-Hunt syndrome? ( 29848513 )
2018
6
Successful Treatment of Tolosa-Hunt Syndrome after a Single Infusion of Infliximab. ( 29629550 )
2018
7
Tolosa-Hunt Syndrome and Ocular Myasthenia: A Rare Coexistence or Real Association. ( 28457040 )
2017
8
Bilateral Tolosa-Hunt syndrome mimicking pituitary adenoma. ( 29032531 )
2017
9
Atypical Tolosa Hunt syndrome with bilateral sclerokeratitis and optic atrophy in Takayasu's arteritis. ( 29503945 )
2017
10
Tolosa-Hunt Syndrome ( 29083745 )
2017
11
Tolosa-Hunt Syndrome Demonstrated by Constructive Interference Steady State Magnetic Resonance Imaging. ( 28299013 )
2017
12
Tolosa-Hunt Syndrome - Case Report. ( 29485802 )
2017
13
Merkel Cell Carcinoma with Distant Metastasis to the Clivus Causing Symptoms Mimicking Tolosa-Hunt Syndrome: A Case Report and Literature Review. ( 28868044 )
2017
14
An Interesting Case of Tolosa-Hunt Syndrome in a Young Male. ( 28210639 )
2017
15
Tolosa-Hunt syndrome presenting during pregnancy following progesterone administration. ( 28295285 )
2017
16
Tolosa-Hunt Syndrome: Appraising the ICHD-3 beta diagnostic criteria. ( 29169256 )
2017
17
Tolosa-Hunt Syndrome - Cranial Neuroimaging Findings. ( 29033638 )
2017
18
Chronic recurrent multifocal osteomyelitis presenting with Tolosa-Hunt syndrome in a 13-year-old boy. ( 28598320 )
2017
19
Steroid-resistant Tolosa-Hunt syndrome with a de novo intracavernous aneurysm: A case report. ( 27920936 )
2016
20
Evaluation and Management of Tolosa-Hunt Syndrome inA Children: A Clinical Update. ( 27473647 )
2016
21
Steroid-responsive painful ophthalmoplegia: Tolosa-Hunt syndrome, Eales disease, or both? ( 26842710 )
2016
22
Cryopyrin-associated periodic fever syndrome manifesting as Tolosa-Hunt syndrome. ( 26848126 )
2016
23
Actinomycosis Mimicking Tolosa-Hunt Syndrome in a 6-Year-Old Boy: Case Report. ( 27070954 )
2016
24
Tolosa-Hunt syndrome with spontaneous remission and recurrence. ( 26976551 )
2016
25
Tolosa-Hunt syndrome and comorbidity of obsessive compulsive disorder and aortic aneurysm. ( 27872048 )
2016
26
Bilateral Painful Ophthalmoplegia: A Case of Assumed Tolosa-Hunt Syndrome. ( 27134970 )
2016
27
Tolosa-Hunt Syndrome: Another legitimate target for radiosurgery? ( 26611688 )
2016
28
Gamma Knife radiosurgery in steroid-intolerant Tolosa-Hunt syndrome: case report. ( 26611689 )
2016
29
The evaluation of ICHD-3 beta diagnostic criteria for Tolosa-Hunt syndrome: a study of 22 cases of Tolosa-Hunt syndrome. ( 25736249 )
2015
30
Tolosa-hunt syndrome in double-hit lymphoma. ( 25918657 )
2015
31
Lymphoma of the orbit masquerading as Tolosa-Hunt syndrome. ( 25971316 )
2015
32
Tolosa-Hunt syndrome: an arcane pathology of cavernous venous sinus. ( 26294359 )
2015
33
Clinical and radiological findings suggesting disorders other than tolosa-hunt syndrome among ophthalmoplegic patients: a retrospective analysis. ( 25688645 )
2015
34
Tolosa-Hunt syndrome masquerading as a carotid artery dissection. ( 24741291 )
2014
35
Corrections to "Validation of ICHD-3 beta diagnostic criteria for 13.7 Tolosa-Hunt syndrome: Analysis of 77 cases of painful ophthalmoplegia" ( 24836214 )
2014
36
Factors that influence Tolosa-Hunt syndrome and the short-term response to steroid pulse treatment. ( 24703581 )
2014
37
Medical image. An unusual case of painful ophthalmoplegia. Tolosa-Hunt syndrome. ( 25145371 )
2014
38
Probable Tolosa-Hunt syndrome with a normal MRI. ( 24939752 )
2014
39
Validation of ICHD-3 beta diagnostic criteria for 13.7 Tolosa-Hunt syndrome: Analysis of 77 cases of painful ophthalmoplegia. ( 24477599 )
2014
40
Giant thrombosed intracavernous carotid artery aneurysm presenting as Tolosa-Hunt syndrome in a patient harboring a new pathogenic neurofibromatosis type 1 mutation: a case report and review of the literature. ( 24476631 )
2014
41
Painful ophthalmoplegia: a case of tolosa-hunt syndrome. ( 25373075 )
2014
42
MRI findings in Tolosa-Hunt syndrome (THS). ( 25368129 )
2014
43
Tolosa-Hunt syndrome--a rare cause of headache and ophthalmoplegia. ( 24012271 )
2013
44
Microsurgical findings of Tolosa-Hunt syndrome. ( 22484067 )
2013
45
Tolosa-Hunt syndrome mimicking cavernous sinus tumor. ( 23670334 )
2013
46
Tolosa-Hunt syndrome masquerading as Gradenigo syndrome in a teenager. ( 23684166 )
2013
47
Utility of thallium-201 scintigraphy in Tolosa-Hunt syndrome. ( 23291611 )
2013
48
A comparison of benign and inflammatory manifestations of Tolosa-Hunt syndrome. ( 23475292 )
2013
49
[A case of Tolosa-Hunt syndrome presenting ocular neuromyotonia]. ( 23719987 )
2013
50
Tolosa-hunt syndrome associated with cytomegalovirus infection. ( 23676602 )
2013

Variations for Tolosa-Hunt Syndrome

Expression for Tolosa-Hunt Syndrome

Search GEO for disease gene expression data for Tolosa-Hunt Syndrome.

Pathways for Tolosa-Hunt Syndrome

Pathways related to Tolosa-Hunt Syndrome according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.3 CCL1 NF1

GO Terms for Tolosa-Hunt Syndrome

Biological processes related to Tolosa-Hunt Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.13 CCL1 NF1 PRTN3
2 positive regulation of interleukin-4 production GO:0032753 8.62 CD40LG NLRP3

Sources for Tolosa-Hunt Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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