THS
MCID: TLS001
MIFTS: 34

Tolosa-Hunt Syndrome (THS)

Categories: Eye diseases, Muscle diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Tolosa-Hunt Syndrome

MalaCards integrated aliases for Tolosa-Hunt Syndrome:

Name: Tolosa-Hunt Syndrome 11 19 58 75 43 14 71
Painful Ophthalmoplegia 19 58
Nonspecific Inflammation of the Cavernous Sinus or Superior Orbital Fissure 19
Ophthalmoplegia, Painful 71
Tolosa Hunt Syndrome 19
Ths 19

Characteristics:


Age Of Onset:

All ages 58

Classifications:

Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 11 DOID:1278
MeSH 43 D020333
NCIt 49 C85193
SNOMED-CT 68 75111000
MESH via Orphanet 44 C531833 D020333
ICD10 via Orphanet 32 H49.8
UMLS via Orphanet 72 C0040381 C0392060
Orphanet 58 ORPHA64686
UMLS 71 C0040381 C0392060

Summaries for Tolosa-Hunt Syndrome

GARD: 19 Tolosa Hunt syndrome (THS) is a rare condition characterized by painful ophthalmoplegia (paralysis and/or weakness of the eye muscles). Signs and symptoms include a constant pain behind the eye; decreased eye movements; and signs of cranial nerve paralysis such as drooping of the upper eyelid (ptosis), double vision (diplopia), large pupil, and facial numbness. Although it is considered a benign condition, permanent neurologic deficits can occur and relapses are common. The features of THS are caused by inflammation of the cavernous sinus (an area at the base of the brain) but the underlying cause of the inflammation is unknown.

MalaCards based summary: Tolosa-Hunt Syndrome, also known as painful ophthalmoplegia, is related to bell's palsy and sarcoidosis 1, and has symptoms including ophthalmoplegia An important gene associated with Tolosa-Hunt Syndrome is PRTN3 (Proteinase 3). Affiliated tissues include eye, brain and pituitary, and related phenotype is cardiovascular system.

Orphanet: 58 Tolosa-Hunt syndrome is an ophthalmoplegic syndrome, affecting all age groups, characterized by acute attacks (lasting a few days to a few weeks) of periorbital pain, ipsilateral ocular motor nerve palsies, ptosis, disordered eye movements and blurred vision usually caused by a non-specific inflammatory process in the cavernous sinus and superior orbital fissure. It has an unpredicatable course with spontaneous remission occurring in some and recurrence of attacks in others.

Wikipedia: 75 Tolosa-Hunt syndrome is a rare disorder characterized by severe and unilateral headaches with orbital... more...

Related Diseases for Tolosa-Hunt Syndrome

Diseases related to Tolosa-Hunt Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 392)
# Related Disease Score Top Affiliating Genes
1 bell's palsy 31.3 CRP ACE
2 sarcoidosis 1 31.0 PRTN3 CRP ACE
3 cranial nerve palsy 31.0 PRTN3 CRP ACE
4 facial paralysis 30.9 PRTN3 CRP ACE
5 multiple cranial nerve palsy 30.8 PRTN3 CRP ACE
6 sclerosing keratitis 30.5 PRTN3 CRP
7 arteriolosclerosis 30.4 CRP ACE
8 papilledema 30.4 CRP ACE
9 mononeuropathy 30.3 PRTN3 CRP ACE
10 scleritis 30.3 PRTN3 CRP
11 igg4-related disease 30.2 PRTN3 CRP
12 pulmonary disease, chronic obstructive 30.1 PRTN3 CRP ACE
13 posterior scleritis 30.1 PRTN3 CRP ACE
14 neurosarcoidosis 30.1 PRTN3 CRP ACE
15 coronary heart disease 1 29.9 CRP ACE
16 temporal arteritis 29.7 PRTN3 MTUS2 MTUS1 CRP ACE
17 aseptic meningitis 29.6 MTUS2 MTUS1 CRP
18 orbital plasma cell granuloma 29.4 PRTN3 MTUS2 MTUS1 CRP
19 exanthem 29.0 PRTN3 MTUS2 MTUS1 CRP ACE
20 herpes zoster oticus 11.4
21 kearns-sayre syndrome 11.2
22 acute ackee fruit intoxication 11.0
23 ptosis 10.8
24 headache 10.7
25 abducens palsy 10.6
26 meningioma, familial 10.6
27 papillon-lefevre syndrome 10.6
28 sarcoidosis 2 10.6
29 migraine with or without aura 1 10.5
30 vascular disease 10.5
31 b-cell lymphoma 10.4
32 burkitt lymphoma 10.4
33 systemic lupus erythematosus 10.4
34 trigeminal neuralgia 10.4
35 myasthenia gravis 10.4
36 central diabetes insipidus 10.4
37 actinomycosis 10.4
38 neuropathy 10.4
39 diabetes insipidus 10.4
40 polyarteritis nodosa 10.4
41 3-methylglutaconic aciduria, type iii 10.3
42 systemic lupus erythematosus 1 10.3
43 lymphoma 10.3
44 fourth cranial nerve palsy 10.3
45 optic nerve disease 10.3
46 thyroiditis 10.3
47 lupus erythematosus 10.3
48 hypopituitarism 10.3
49 bicipital tenosynovitis 10.3 PRTN3 CRP
50 orbital granuloma 10.3 PRTN3 CRP

Graphical network of the top 20 diseases related to Tolosa-Hunt Syndrome:



Diseases related to Tolosa-Hunt Syndrome

Symptoms & Phenotypes for Tolosa-Hunt Syndrome

UMLS symptoms related to Tolosa-Hunt Syndrome:


ophthalmoplegia

MGI Mouse Phenotypes related to Tolosa-Hunt Syndrome:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.23 ACE CD2BP2 CNDP2 CRP FKBPL GALC

Drugs & Therapeutics for Tolosa-Hunt Syndrome

Search Clinical Trials, NIH Clinical Center for Tolosa-Hunt Syndrome

Cochrane evidence based reviews: tolosa-hunt syndrome

Genetic Tests for Tolosa-Hunt Syndrome

Anatomical Context for Tolosa-Hunt Syndrome

Organs/tissues related to Tolosa-Hunt Syndrome:

MalaCards : Eye, Brain, Pituitary, Salivary Gland, Smooth Muscle, Small Intestine, Breast

Publications for Tolosa-Hunt Syndrome

Articles related to Tolosa-Hunt Syndrome:

(show top 50) (show all 639)
# Title Authors PMID Year
1
Trigeminal neuralgia following Tolosa-Hunt syndrome. 62
33826103 2022
2
Complete ophthalmoplegia diagnosed as Tolosa-Hunt syndrome on interval MRI. 62
36328364 2022
3
A 57-year-old man with painful ophthalmoplegia and cavernous sinus involvement: Why this is not Tolosa-Hunt syndrome. 62
36073199 2022
4
Recurrent Painful Ophthalmoplegic Neuropathy with Unilateral Oculomotor and Trochlear Nerve Palsy in an 8-year-old Girl. 62
35867412 2022
5
Tolosa-Hunt Syndrome and Hemorrhagic Encephalitis Presenting in a Patient after COVID-19 Vaccination Followed by COVID-19 Infection. 62
35884709 2022
6
Neuro-Ophthalmological Complications of the COVID-19 Vaccines: A Systematic Review. 62
35427282 2022
7
A Case Report on a Unique Explanation for Headache With Ophthalmoplegia: The Tolosa-Hunt Syndrome. 62
35875300 2022
8
A case of total ophthalmoplegia associated with a COVID-19 infection: case report. 62
35619686 2022
9
Remarkable Benefit of Infliximab Therapy in Recurrent Tolosa Hunt Syndrome. 62
35864695 2022
10
Tolosa hunt syndrome: A new challenge for anaesthesia. 62
36171926 2022
11
Invasive sphenoid sinus aspergillosis with normal findings on initial diagnostic tests that mimics Tolosa-Hunt syndrome-a diagnostic dilemma: a case report. 62
35272433 2022
12
Hypopituitarism and cranial nerve involvement mimicking Tolosa-Hunt syndrome as the initially presenting feature of diffuse large B-cell lymphoma: a case report. 62
35287660 2022
13
Tolosa-Hunt syndrome presenting with features of a trigeminal autonomic cephalalgias and pituitary enlargement. 62
35232735 2022
14
Critical peritonitis secondary to gastrointestinal mucormycosis in a peritoneal dialysis patient: a case report. 62
34273082 2022
15
Possibility of arterial spin labeling perfusion magnetic resonance imaging sequences with steroid therapy for Tolosa-Hunt syndrome: A case report and review of literature. 62
35127227 2022
16
Clinical and Cerebrospinal Fluid Characteristics in 55 Cases of Tolosa-Hunt Syndrome: A Retrospective Analytical Study. 62
35263741 2022
17
Frozen overnight: Acute orbital apex syndrome caused by aspergillosis. 62
35001696 2022
18
Double Down on Double Vision: An Unusual Case of Painful Diplopia. 62
35111483 2021
19
Recurrent Tolosa-Hunt Syndrome in a Child Accompanied by Idiopathic Aseptic Meningitis. 62
34583233 2021
20
Multiple Cranial Neuropathies and Pachymeningitis in a Patient With a Pathogenic Nucleotide-Binding Oligomerization Domain 2 Polymorphism. 62
34788239 2021
21
Painful ophthalmoplegia syndrome, beyond Tolosa-Hunt syndrome. A case series. 62
34844691 2021
22
Recurrent painful ophthalmoplegic neuropathy: a cause for recurrent third nerve palsy in a child. 62
34764123 2021
23
Escaping from the hunt. 62
33129799 2021
24
From left to right: an unusual presentation of Tolosa-Hunt syndrome with bilateral eye involvement. 62
34695104 2021
25
Painful ophthalmoplegia in a patient with a history of marginal zone lymphoma. 62
34617167 2021
26
Primary intracranial aggressive fibromatosis arising in sella turcica: illustrative case. 62
35855410 2021
27
The demographics of Tolosa-Hunt syndrome in Qatar. 62
34355072 2021
28
Tolosa-Hunt Syndrome Misdiagnosed as Surgical Complication After Frontal Balloon Sinuplasty. 62
33534326 2021
29
The youngest Japanese case of Tolosa-Hunt syndrome. 62
34176188 2021
30
Multiple Spontaneous Visceral Arterial Dissections in a Patient With Tolosa-Hunt Syndrome on Corticosteroid Therapy. 62
33838239 2021
31
Steroid responsive cavernous sinus syndrome due to Rosai-Dorfman disease: beyond Tolosa-Hunt syndrome - a case report. 62
34225703 2021
32
Tolosa-Hunt Syndrome Presenting After COVID-19 Vaccination. 62
34513398 2021
33
Recurrent Tolosa-Hunt syndrome. 62
34386372 2021
34
Tolosa-Hunt Syndrome: A Case Report. 62
34508416 2021
35
Tolosa-Hunt Syndrome With Anisocoria as the Sole Presenting Ophthalmic Sign. 62
34115450 2021
36
Dynamic alteration of internal carotid artery related to granuloma in a case of Tolosa-Hunt syndrome. 62
34184194 2021
37
The clinical features and outcomes of Tolosa-Hunt syndrome. 62
34044807 2021
38
Recurrent Amaurosis Fugax Secondary to Tolosa-Hunt Syndrome: A Case Report and Review of Phenotypes and Pathology. 62
34221749 2021
39
Tolosa-Hunt Syndrome: A Review of Diagnostic Criteria and Unresolved Issues. 62
34409218 2021
40
Tolosa-Hunt syndrome as initial presentation of Systemic Lupus Erythematosus. 62
34549400 2021
41
Tolosa-Hunt Syndrome as an Initial Presentation of Sarcoidosis. 62
31488356 2021
42
Tolosa-Hunt Syndrome in Childhood and Adolescence: A Literature Review in the Last 10 Years. 62
32892335 2021
43
Tolosa-Hunt Syndrome with underlying latent tuberculosis: a diagnostic dilemma. 62
33875960 2021
44
Recurrent painful ophthalmoplegic neuropathy revealing oculomotor nerve schwannoma. 62
35261021 2021
45
Tolosa-Hunt syndrome relapse during pregnancy following chronic intake of combined oral contraceptives. 62
33462037 2021
46
[Primary vasculitis of internal carotid and vertebral arteries: a role of cytokines, transforming growth factor beta 1 and basic fibroblast growth factor]. 62
34460152 2021
47
Ophthalmoplegia and cranial nerve deficits in an adolescent with headache. 62
34178348 2021
48
Tolosa-Hunt syndrome as a manifestation of Hypertrophic Pachymeningitis. 62
32910772 2021
49
Magnetic resonance imaging (MRI) versus computed tomographic scan (CT scan) of brain in evaluation of suspected cavernous sinus syndrome. 62
33283671 2020
50
Cavernous sinus lesions. 62
32574933 2020

Variations for Tolosa-Hunt Syndrome

Expression for Tolosa-Hunt Syndrome

Search GEO for disease gene expression data for Tolosa-Hunt Syndrome.

Pathways for Tolosa-Hunt Syndrome

GO Terms for Tolosa-Hunt Syndrome

Molecular functions related to Tolosa-Hunt Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallodipeptidase activity GO:0070573 8.92 CNDP2 ACE

Sources for Tolosa-Hunt Syndrome

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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