MCID: TNG004
MIFTS: 43

Tongue Disease

Categories: Gastrointestinal diseases, Oral diseases, Smell/Taste diseases

Aliases & Classifications for Tongue Disease

MalaCards integrated aliases for Tongue Disease:

Name: Tongue Disease 12 15
Abnormality of the Tongue 29 6
Tongue Diseases 44 70
Tongue Disorders 42

Classifications:



External Ids:

Disease Ontology 12 DOID:10944
ICD9CM 34 529.9
MeSH 44 D014060
SNOMED-CT 67 69244009
ICD10 32 K14 K14.9
UMLS 70 C0040409

Summaries for Tongue Disease

MedlinePlus : 42 Your tongue helps you taste, swallow, and chew. You also use it to speak. Your tongue is made up of many muscles. The upper surface contains your taste buds. Problems with the tongue include Pain Swelling Changes in color or texture Abnormal movement or difficulty moving the tongue Taste problems These problems can have many different causes. Treatment depends on the underlying problem.

MalaCards based summary : Tongue Disease, also known as abnormality of the tongue, is related to skin disease and lymphoma, hodgkin, classic, and has symptoms including snoring, halitosis and oral manifestations. An important gene associated with Tongue Disease is TP53 (Tumor Protein P53), and among its related pathways/superpathways are DNA Damage Response and MicroRNAs in cancer. The drugs Paclitaxel and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include tongue, kidney and skin.

Disease Ontology : 12 A mouth disease located in the tongue.

Wikipedia : 73 Tongue diseases can be congenital or acquired, and are multiple in number. Considered according to a... more...

Related Diseases for Tongue Disease

Diseases related to Tongue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 skin disease 30.1 TP53 MIR483 MIR31 MIR30A MIR21 MIR196A1
2 lymphoma, hodgkin, classic 30.0 MIR30A MIR21 MIR18A
3 lymphoma, non-hodgkin, familial 29.8 TP53 MIR486-1 MIR483 MIR31 MIR30A MIR21
4 muscular dystrophy, limb-girdle, autosomal recessive 5 10.9
5 ankyloglossia with or without tooth anomalies 10.8
6 verrucous carcinoma 10.5 TP53 MIR31 MIR195
7 esophagus adenocarcinoma 10.5 TP53 MIR21 MIR196A1 MIR145
8 ovarian serous carcinoma 10.5 TP53 MIR99A MIR21 MIR145
9 lichen disease 10.5 TP53 MIR31 CCR6
10 adrenal cortex disease 10.5 TP53 MIR483 MIR139 CCR6
11 leiomyoma, uterine 10.5 MIR486-1 MIR30A MIR21 MIR139
12 ampulla of vater cancer 10.5 TP53 MIR196A1 MIR145
13 heart valve disease 10.5 MIR486-1 MIR21 MIR195 MIR17
14 adrenal gland disease 10.5 TP53 MIR483 MIR139 CCR6
15 adrenal cortical carcinoma 10.5 TP53 MIR483 MIR195 MIR139
16 papillary adenocarcinoma 10.5 TP53 MIR30A MIR21
17 pleural cancer 10.5 TP53 MIR193A MIR17 MIR139
18 aortic valve disease 2 10.5 MIR486-1 MIR21 MIR195 MIR17
19 ovarian cystadenocarcinoma 10.5 TP53 MIR30A MIR17
20 cardiovascular organ benign neoplasm 10.5 TP53 MIR15A MIR139 CCR6
21 endocrine organ benign neoplasm 10.5 TP53 MIR483 MIR21 MIR181A1 MIR139
22 oral cancer 10.5 TP53 MIR31 MIR21
23 colorectal adenoma 10.5 TP53 MIR21 MIR17 MIR15A
24 tongue carcinoma 10.5 TP53 MIR31 MIR21 MIR139
25 breast carcinoma in situ 10.5 TP53 MIR30A MIR193A MIR181A1
26 lymph node disease 10.5 MIR483 MIR145 CCR6
27 colonic benign neoplasm 10.5 TP53 MIR18A MIR15A CCR6
28 infratentorial cancer 10.5 TP53 MIR196A1 MIR18A MIR17
29 lower lip cancer 10.5 MIR31 MIR21
30 aortic aneurysm 10.5 MIR21 MIR195 MIR15A MIR145
31 ovary adenocarcinoma 10.5 TP53 MIR30A MIR17
32 pleural disease 10.5 TP53 MIR193A MIR17 CCR6
33 mature t-cell and nk-cell lymphoma 10.5 TP53 MIR17 CCR6
34 bone structure disease 10.5 MIR486-1 MIR17 CCR6
35 testicular disease 10.5 TP53 MIR181A1 CCR6
36 lymphangioma 10.5 TP53 MIR18A MIR15A CCR6
37 muscular disease 10.5 TP53 MIR21 MIR196A1 CCR6
38 aortic disease 10.5 MIR21 MIR195 MIR17 MIR15A MIR145
39 in situ carcinoma 10.5 TP53 MIR193A MIR181A1 MIR17 MIR139
40 chromosomal deletion syndrome 10.5 MIR491 MIR31 MIR17 CCR6
41 bile duct cancer 10.4 TP53 MIR31 MIR21 MIR17 MIR145
42 tongue squamous cell carcinoma 10.4 TP53 MIR483 MIR21 MIR195 MIR181A1 MIR139
43 mature b-cell neoplasm 10.4 TP53 MIR483 MIR196A1 MIR17 CCR6
44 ovarian serous cystadenocarcinoma 10.4 TP53 MIR30A MIR17
45 megacolon 10.4 MIR483 MIR31 CCR6
46 retinal vascular disease 10.4 MIR30A MIR21 MIR17
47 pancreatitis, hereditary 10.4 MIR99A MIR483 MIR195
48 thyroid gland anaplastic carcinoma 10.4 TP53 MIR30A MIR18A MIR181A1 MIR17
49 autoimmune disease of musculoskeletal system 10.4 MIR30A MIR21 MIR196A1 MIR17 CCR6
50 breast implant-associated anaplastic large cell lymphoma 10.4 TP53 CCR6

Graphical network of the top 20 diseases related to Tongue Disease:



Diseases related to Tongue Disease

Symptoms & Phenotypes for Tongue Disease

UMLS symptoms related to Tongue Disease:


snoring; halitosis; oral manifestations; glossalgia; peeling tongue

Drugs & Therapeutics for Tongue Disease

Drugs for Tongue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
4
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
5
Hydroxyurea Approved Phase 2 127-07-1 3657
6
Promethazine Approved, Investigational Phase 2 60-87-7 4927
7
Fluorouracil Approved Phase 2 51-21-8 3385
8
Histamine Approved, Investigational Phase 2 51-45-6, 75614-87-8 774
9
Famotidine Approved Phase 2 76824-35-6 3325
10
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
11
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
12
nivolumab Approved Phase 2 946414-94-4
13
Inulin Approved, Investigational, Nutraceutical Phase 2 9005-80-5 24763
14 Gastrointestinal Agents Phase 2
15 Tubulin Modulators Phase 2
16 Hypnotics and Sedatives Phase 2
17 Anesthetics Phase 2
18 Hormone Antagonists Phase 2
19 Neurotransmitter Agents Phase 2
20 Antimitotic Agents Phase 2
21 Mitogens Phase 2
22 glucocorticoids Phase 2
23 Antiemetics Phase 2
24 Antineoplastic Agents, Immunological Phase 2
25 Histamine H2 Antagonists Phase 2
26 Albumin-Bound Paclitaxel Phase 2
27 Hormones Phase 2
28 Antineoplastic Agents, Hormonal Phase 2
29 Histamine Antagonists Phase 2
30
Histamine Phosphate Phase 2 51-74-1 65513
31 Dermatologic Agents Phase 2
32 Histamine H1 Antagonists Phase 2
33 Anesthetics, Local Phase 2
34 Anti-Ulcer Agents Phase 2
35 Anti-Inflammatory Agents Phase 2
36 Antacids Phase 2
37 Anti-Allergic Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Inulin and Streptococcus Salivarius Reduce Halitosis Associated With Tongue Coating: A Randomized Clinical Trial Completed NCT02794766 Phase 2 Inulin+SS;S salivarius;Placebo
2 A Phase II Trial of Nivolumab/Nab-paclitaxel/Carboplatin Induction Chemotherapy Followed by Response-stratified Locoregional Therapy for Patients With Locoregionally Advanced HPV-related Oropharyngeal Cancer- the OPTIMA II Trial Active, not recruiting NCT03107182 Phase 2 nab-paclitaxel;Carboplatin;Nivolumab;Cisplatin;Hydroxyurea;5-FU;Dexamethasone;Famotidine;Diphenhydramine;Paclitaxel
3 Tongue Depressor-related Tongue Swelling in Adenoidectomy Surgeries in Pediatric Patients Completed NCT04256590

Search NIH Clinical Center for Tongue Disease

Cochrane evidence based reviews: tongue diseases

Genetic Tests for Tongue Disease

Genetic tests related to Tongue Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Tongue 29

Anatomical Context for Tongue Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Tongue Disease:

19
Tongue

MalaCards organs/tissues related to Tongue Disease:

40
Tongue, Kidney, Skin

Publications for Tongue Disease

Articles related to Tongue Disease:

(show all 39)
# Title Authors PMID Year
1
Efficacy of the laser at low intensity on primary burning oral syndrome: a systematic review. 42
33609024 2021
2
The tongue features associated with chronic kidney disease. 42
33655979 2021
3
Short lingual frenum in infants, children and adolescents. Part 2: Lingual frenum release. Functional surgical approach. 42
33719483 2021
4
Oral Health and Undernutrition in the Frail Elderly Persons. 61
33786566 2021
5
Histological study of postnatal development of mouse tongues. 61
29375694 2018
6
Economic analysis of animal disease outbreaks--BSE and Bluetongue disease as examples. 61
26697715 2015
7
Integrated fly management in European ruminant operations from the perspective of directive 2009/128/EC on sustainable use of pesticides. 61
25547079 2015
8
Tongue lesions. 61
23172472 2012
9
[Vigilance for veterinary medicinal products: declarations of adverse reactions in the year 2010]. 61
22287137 2012
10
Swallowing function after transoral laser microsurgery (TLM) ± adjuvant therapy for advanced-stage oropharyngeal cancer. 61
21882203 2011
11
[Vigilance for veterinary medicinal products: declarations of adverse reactions in the year 2009]. 61
21104632 2010
12
[Vigilance for veterinary medicinal products: declarations of adverse reactions in the year 2008]. 61
19946849 2009
13
Tongue color analysis and discrimination based on hyperspectral images. 61
19157779 2009
14
Culicoides and the Tartar Steppe: Il Deserto dei Tartari Culicoides and the spread of blue tongue virus. 61
20055234 2008
15
[Blue tongue disease: mystery and hope (2)]. 61
18831414 2008
16
[Blue tongue disease: mystery and hope (I)]. 61
18072608 2007
17
[Postoperative recurrence-related factors of 125 patients with cT1-2N0 squamous cell carcinoma of the oral tongue]. 61
17562277 2007
18
[What is your diagnosis? Tongue diseases]. 61
17205930 2006
19
Tongue disease in advanced AIDS. 61
15752079 2005
20
Case report: Oral pemphigus vulgaris with multiple oral polyps in a young patient. 61
12653338 2003
21
Non neoplastic tongue diseases. An epidemiological investigation and diagnostic criteria. 61
10822712 1999
22
[Determination of the salivary composition in patients with tongue diseases] 61
15048299 1999
23
Architectural organization of filiform papillae in normal and black hairy tongue epithelium: dissection of differentiation pathways in a complex human epithelium according to their patterns of keratin expression. 61
10052403 1999
24
[Incidence of tongue diseases based on epidemiologic studies (review of the literature)]. 61
1291323 1992
25
Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. 61
2802032 1989
26
Sialochemistry in mucosal lesions of the tongue: electrolytes and total protein. 61
3088162 1986
27
[Knowledge of tongue diseases 1000 years ago]. 61
6385353 1983
28
[Various tongue diseases]. 61
7099291 1982
29
[Clinical diagnosis of tongue changes and tongue diseases (IV)]. 61
6952362 1980
30
[Clinical diagnosis of tongue changes and tongue diseases (III)]. 61
6952356 1980
31
[Clinical diagnosis of tongue changes and tongue diseases (II)]. 61
6952341 1980
32
[Clinical diagnosis of tongue changes and tongue diseases (I)]. 61
6952304 1980
33
[Skin diseases, tongue diseases and lip diseases in the Soviet literature during the years 1961-1973]. 61
4531378 1974
34
[Tongue diseases]. 61
5284640 1971
35
[Ultrastructure of the surface of the mucosa of the oral cavity by electron scanning microscopy--normal specimen and pathologic condition with various tongue diseases]. 61
5466826 1970
36
[TONGUE DISEASES IN RELATION TO INTERNAL DISEASES AND AFTER ADMINISTRATION OF DRUGS]. 61
14095298 1963
37
[Diagnosis & therapy of tongue diseases]. 61
13482722 1957
38
[Unusual tongue diseases in typhoid treated with chloramphenicol]. 61
14864922 1951
39
On the Influence of the Teeth on Tongue Disease. 61
33703128 1883

Variations for Tongue Disease

ClinVar genetic disease variations for Tongue Disease:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 TP53 NM_000546.6(TP53):c.742C>T (p.Arg248Trp) SNV Pathogenic 12347 rs121912651 GRCh37: 17:7577539-7577539
GRCh38: 17:7674221-7674221
2 DNAJC21 NM_001012339.3(DNAJC21):c.544C>T (p.Arg182Ter) SNV Pathogenic 598950 rs771063992 GRCh37: 5:34937536-34937536
GRCh38: 5:34937431-34937431
3 SOX3 NM_005634.2(SOX3):c.735_737dup (p.Ala248dup) Duplication Uncertain significance 95305 rs398124211 GRCh37: X:139586488-139586489
GRCh38: X:140504323-140504324

Expression for Tongue Disease

Search GEO for disease gene expression data for Tongue Disease.

Pathways for Tongue Disease

Pathways related to Tongue Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.99 TP53 MIR18A MIR181A1 MIR17
2 11.89 TP53 MIR99A MIR483 MIR31 MIR30A MIR21
3 11.63 TP53 MIR21 MIR181A1 MIR139
4 11.18 MIR30A MIR195 MIR18A MIR17
5 11.13 TP53 MIR181A1 MIR145

GO Terms for Tongue Disease

Cellular components related to Tongue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 MIR99A MIR486-1 MIR31 MIR30A MIR21 MIR18A
2 extracellular vesicle GO:1903561 9.1 MIR99A MIR30A MIR21 MIR193A MIR17 MIR15A

Biological processes related to Tongue Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.85 TP53 MIR33A MIR21 MIR181A1 MIR17
2 negative regulation of inflammatory response GO:0050728 9.73 MIR31 MIR181A1 MIR15A MIR145
3 negative regulation of angiogenesis GO:0016525 9.71 MIR21 MIR193A MIR15A MIR145
4 transforming growth factor beta receptor signaling pathway GO:0007179 9.7 TP53 MIR30A MIR21
5 negative regulation of G1/S transition of mitotic cell cycle GO:2000134 9.67 MIR21 MIR193A MIR15A
6 positive regulation of endothelial cell differentiation GO:0045603 9.56 MIR21 MIR181A1
7 negative regulation of cardiac muscle hypertrophy GO:0010614 9.55 MIR21 MIR145
8 gene silencing by miRNA GO:0035195 9.55 MIR99A MIR491 MIR486-1 MIR483 MIR33A MIR31
9 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.54 MIR21 MIR181A1
10 negative regulation of vascular endothelial growth factor production GO:1904046 9.54 MIR195 MIR17 MIR15A
11 positive regulation of metalloendopeptidase activity GO:1904685 9.51 MIR21 MIR17
12 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 9.5 MIR483 MIR193A MIR15A
13 miRNA mediated inhibition of translation GO:0035278 9.5 MIR483 MIR31 MIR21 MIR181A1 MIR17 MIR15A
14 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.48 MIR21 MIR17
15 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.46 MIR483 MIR196A1 MIR193A MIR15A
16 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.43 TP53 MIR195 MIR17

Molecular functions related to Tongue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.7 TP53 MIR31 MIR30A MIR21 MIR195 MIR193A
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.53 MIR99A MIR491 MIR483 MIR33A MIR31 MIR30A
3 RNA polymerase II complex binding GO:0000993 9.33 MIR33A MIR145 MIR139

Sources for Tongue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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