MCID: TNG004
MIFTS: 42

Tongue Disease

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Tongue Disease

MalaCards integrated aliases for Tongue Disease:

Name: Tongue Disease 12 15
Abnormality of the Tongue 29 6
Tongue Diseases 43 71
Tongue Disorders 42

Classifications:



External Ids:

Disease Ontology 12 DOID:10944
ICD9CM 34 529.9
MeSH 43 D014060
SNOMED-CT 67 69244009
ICD10 32 K14 K14.9
UMLS 71 C0040409

Summaries for Tongue Disease

MedlinePlus : 42 Your tongue helps you taste, swallow, and chew. You also use it to speak. Your tongue is made up of many muscles. The upper surface contains your taste buds. Problems with the tongue include Pain Swelling Changes in color or texture Abnormal movement or difficulty moving the tongue Taste problems These problems can have many different causes. Treatment depends on the underlying problem.

MalaCards based summary : Tongue Disease, also known as abnormality of the tongue, is related to lymphoma, hodgkin, classic and lymphoma, non-hodgkin, familial, and has symptoms including halitosis, snoring and oral manifestations. An important gene associated with Tongue Disease is TP53 (Tumor Protein P53), and among its related pathways/superpathways are DNA Damage Response and MicroRNAs in cancer. The drugs Dexamethasone acetate and Histamine have been mentioned in the context of this disorder. Affiliated tissues include tongue, salivary gland and skin.

Wikipedia : 74 Tongue diseases can be congenital or acquired, and are multiple in number. Considered according to a... more...

Related Diseases for Tongue Disease

Diseases related to Tongue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 lymphoma, hodgkin, classic 30.3 MIR30A MIR21 MIR18A MIR186
2 lymphoma, non-hodgkin, familial 29.9 TP53 MIR486-1 MIR483 MIR30A MIR21 MIR199A1
3 ankyloglossia with or without tooth anomalies 10.9
4 muscular dystrophy, limb-girdle, autosomal recessive 5 10.9
5 cystadenocarcinoma 10.7 TP53 MIR30A MIR199A1
6 b-cell lymphoma 10.7 TP53 MIR21 MIR181A1 MIR17
7 esophagus adenocarcinoma 10.7 TP53 MIR21 MIR196A1 MIR145
8 adrenocortical carcinoma, hereditary 10.7 TP53 MIR483 MIR195
9 pleural cancer 10.7 TP53 MIR17 MIR139
10 ovarian serous carcinoma 10.6 TP53 MIR21 MIR199A1 MIR145
11 adrenal cortical carcinoma 10.6 TP53 MIR483 MIR139
12 thyroid gland anaplastic carcinoma 10.6 TP53 MIR30A MIR18A MIR17
13 adrenal cortex disease 10.6 TP53 MIR483 MIR139
14 adrenal gland disease 10.6 TP53 MIR483 MIR139
15 papillary adenocarcinoma 10.6 TP53 MIR30A MIR21
16 skeletal muscle cancer 10.6 TP53 MIR486-1 MIR199A1 MIR196A1
17 muscle cancer 10.6 TP53 MIR486-1 MIR199A1 MIR196A1
18 pre-malignant neoplasm 10.6 TP53 MIR30A MIR17 MIR139
19 serous cystadenocarcinoma 10.6 TP53 MIR30A MIR199A1 MIR139
20 in situ carcinoma 10.6 TP53 MIR30A MIR17 MIR139
21 gallbladder disease 10.6 TP53 MIR199A1 MIR17 MIR145
22 ampulla of vater cancer 10.6 MIR196A1 MIR181A1 MIR145
23 aortic valve disease 2 10.6 MIR486-1 MIR21 MIR199A1 MIR17
24 infratentorial cancer 10.6 TP53 MIR18A MIR186 MIR17
25 testicular disease 10.6 TP53 MIR199A1 MIR181A1
26 bone cancer 10.6 TP53 MIR21 MIR199A1 MIR195
27 chromosomal disease 10.6 MIR486-1 MIR483 MIR196A1 MIR17
28 intrinsic cardiomyopathy 10.6 MIR486-1 MIR30A MIR21 MIR199A1
29 pancreatitis, hereditary 10.6 MIR483 MIR199A1 MIR195
30 larynx cancer 10.6 TP53 MIR21 MIR196A1 MIR17 MIR139
31 leiomyoma, uterine 10.6 MIR486-1 MIR30A MIR21 MIR139
32 ovary adenocarcinoma 10.6 TP53 MIR30A MIR17
33 contractures, pterygia, and variable skeletal fusions syndrome 1a 10.6 TP53 MIR199A1 MIR196A1 MIR17
34 ovarian cystadenocarcinoma 10.6 TP53 MIR483 MIR30A MIR196A1 MIR17
35 mature b-cell neoplasm 10.6 TP53 MIR199A1 MIR196A1 MIR181A1 MIR17
36 breast carcinoma in situ 10.6 TP53 MIR30A MIR17
37 autonomic nervous system neoplasm 10.6 TP53 MIR199A1 MIR196A1 MIR181A1 MIR17
38 ovarian serous cystadenocarcinoma 10.6 TP53 MIR483 MIR30A MIR196A1 MIR17
39 pharynx squamous cell carcinoma 10.6 MIR196A1 MAU2
40 lymphatic system disease 10.6 TP53 MIR483 MIR17
41 inherited metabolic disorder 10.6 MIR33A MIR21 MIR199A1 MIR17
42 laryngeal disease 10.6 TP53 MIR486-1 MIR21 MIR196A1 MIR17 MIR139
43 ovarian disease 10.6 TP53 MIR21 MIR199A1 MIR17 MIR145
44 bile duct cancer 10.6 TP53 MIR483 MIR199A1 MIR17
45 thyroid gland papillary carcinoma 10.6 MIR486-1 MIR30A MIR199A1 MIR181A1 MIR17
46 retinal vascular disease 10.6 MIR30A MIR21 MIR199A1
47 cervix carcinoma 10.6 TP53 MIR199A1 MIR139
48 tongue cancer 10.6 TP53 MIR491 MIR21
49 disease of mental health 10.6 MIR30A MIR21 MIR199A1 MIR181A1 MIR17
50 polymyositis 10.6 MIR30A MIR21

Graphical network of the top 20 diseases related to Tongue Disease:



Diseases related to Tongue Disease

Symptoms & Phenotypes for Tongue Disease

UMLS symptoms related to Tongue Disease:


halitosis, snoring, oral manifestations, glossalgia, peeling tongue

Drugs & Therapeutics for Tongue Disease

Drugs for Tongue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
2
Histamine Approved, Investigational Phase 2 51-45-6 774
3
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
4
nivolumab Approved Phase 2 946414-94-4
5
Paclitaxel Approved, Vet_approved Phase 2 33069-62-4 36314
6
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
7
Diphenhydramine Approved, Investigational Phase 2 58-73-1, 147-24-0 3100
8
Famotidine Approved Phase 2 76824-35-6 3325
9
Fluorouracil Approved Phase 2 51-21-8 3385
10
Hydroxyurea Approved Phase 2 127-07-1 3657
11
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
12
Promethazine Approved, Investigational Phase 2 60-87-7 4927
13
Inulin Approved, Investigational, Nutraceutical Phase 2 9005-80-5 24763
14 Neurotransmitter Agents Phase 2
15 Anesthetics, Local Phase 2
16 HIV Protease Inhibitors Phase 2
17 Anti-Ulcer Agents Phase 2
18
protease inhibitors Phase 2
19 Gastrointestinal Agents Phase 2
20 Anti-Inflammatory Agents Phase 2
21 Antiemetics Phase 2
22 Anesthetics Phase 2
23 Dermatologic Agents Phase 2
24 glucocorticoids Phase 2
25 Mitogens Phase 2
26 Antineoplastic Agents, Hormonal Phase 2
27 Albumin-Bound Paclitaxel Phase 2
28 Histamine Antagonists Phase 2
29 Antimitotic Agents Phase 2
30 Histamine H1 Antagonists Phase 2
31 BB 1101 Phase 2
32 Hormone Antagonists Phase 2
33 Antineoplastic Agents, Immunological Phase 2
34 Autonomic Agents Phase 2
35 Central Nervous System Depressants Phase 2
36
Histamine Phosphate Phase 2 51-74-1 65513
37 Antacids Phase 2
38 Anti-Allergic Agents Phase 2
39 Hypnotics and Sedatives Phase 2
40 Histamine H2 Antagonists Phase 2
41 Hormones Phase 2
42 Antipruritics Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Inulin and Streptococcus Salivarius Reduce Halitosis Associated With Tongue Coating: A Randomized Clinical Trial Completed NCT02794766 Phase 2 Inulin+SS;S salivarius;Placebo
2 A Phase II Trial of Nivolumab/Nab-paclitaxel/Carboplatin Induction Chemotherapy Followed by Response-stratified Locoregional Therapy for Patients With Locoregionally Advanced HPV-related Oropharyngeal Cancer- the OPTIMA II Trial Recruiting NCT03107182 Phase 2 nab-paclitaxel;Carboplatin;Nivolumab;Cisplatin;Hydroxyurea;5-FU;Dexamethasone;Famotidine;Diphenhydramine;Paclitaxel

Search NIH Clinical Center for Tongue Disease

Cochrane evidence based reviews: tongue diseases

Genetic Tests for Tongue Disease

Genetic tests related to Tongue Disease:

# Genetic test Affiliating Genes
1 Abnormality of the Tongue 29

Anatomical Context for Tongue Disease

MalaCards organs/tissues related to Tongue Disease:

40
Tongue, Salivary Gland, Skin

Publications for Tongue Disease

Articles related to Tongue Disease:

(show all 37)
# Title Authors PMID Year
1
Oral leukoplakia; a proposal for simplification and consistency of the clinical classification and terminology. 42
31655843 2019
2
Prognostic value of blood and lymphatic vessel markers in tongue cancer: A systematic review. 42
31495050 2019
3
Using weighted gene co-expression network analysis to identify key modules and hub genes in tongue squamous cell carcinoma. 42
31517839 2019
4
Histological study of postnatal development of mouse tongues. 61
29375694 2018
5
Economic analysis of animal disease outbreaks--BSE and Bluetongue disease as examples. 61
26697715 2015
6
Integrated fly management in European ruminant operations from the perspective of directive 2009/128/EC on sustainable use of pesticides. 61
25547079 2015
7
Tongue lesions. 61
23172472 2012
8
[Vigilance for veterinary medicinal products: declarations of adverse reactions in the year 2010]. 61
22287137 2012
9
Swallowing function after transoral laser microsurgery (TLM) ± adjuvant therapy for advanced-stage oropharyngeal cancer. 61
21882203 2011
10
[Vigilance for veterinary medicinal products: declarations of adverse reactions in the year 2009]. 61
21104632 2010
11
[Vigilance for veterinary medicinal products: declarations of adverse reactions in the year 2008]. 61
19946849 2009
12
Tongue color analysis and discrimination based on hyperspectral images. 61
19157779 2009
13
Culicoides and the Tartar Steppe: Il Deserto dei Tartari Culicoides and the spread of blue tongue virus. 61
20055234 2008
14
[Blue tongue disease: mystery and hope (2)]. 61
18831414 2008
15
[Blue tongue disease: mystery and hope (I)]. 61
18072608 2007
16
[Postoperative recurrence-related factors of 125 patients with cT1-2N0 squamous cell carcinoma of the oral tongue]. 61
17562277 2007
17
[What is your diagnosis? Tongue diseases]. 61
17205930 2006
18
Tongue disease in advanced AIDS. 61
15752079 2005
19
Case report: Oral pemphigus vulgaris with multiple oral polyps in a young patient. 61
12653338 2003
20
Non neoplastic tongue diseases. An epidemiological investigation and diagnostic criteria. 61
10822712 1999
21
[Determination of the salivary composition in patients with tongue diseases] 61
15048299 1999
22
Architectural organization of filiform papillae in normal and black hairy tongue epithelium: dissection of differentiation pathways in a complex human epithelium according to their patterns of keratin expression. 61
10052403 1999
23
[Incidence of tongue diseases based on epidemiologic studies (review of the literature)]. 61
1291323 1992
24
Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. 61
2802032 1989
25
Sialochemistry in mucosal lesions of the tongue: electrolytes and total protein. 61
3088162 1986
26
[Knowledge of tongue diseases 1000 years ago]. 61
6385353 1983
27
[Various tongue diseases]. 61
7099291 1982
28
[Clinical diagnosis of tongue changes and tongue diseases (IV)]. 61
6952362 1980
29
[Clinical diagnosis of tongue changes and tongue diseases (III)]. 61
6952356 1980
30
[Clinical diagnosis of tongue changes and tongue diseases (II)]. 61
6952341 1980
31
[Clinical diagnosis of tongue changes and tongue diseases (I)]. 61
6952304 1980
32
[Skin diseases, tongue diseases and lip diseases in the Soviet literature during the years 1961-1973]. 61
4531378 1974
33
[Tongue diseases]. 61
5284640 1971
34
[Ultrastructure of the surface of the mucosa of the oral cavity by electron scanning microscopy--normal specimen and pathologic condition with various tongue diseases]. 61
5466826 1970
35
[TONGUE DISEASES IN RELATION TO INTERNAL DISEASES AND AFTER ADMINISTRATION OF DRUGS]. 61
14095298 1963
36
[Diagnosis & therapy of tongue diseases]. 61
13482722 1957
37
[Unusual tongue diseases in typhoid treated with chloramphenicol]. 61
14864922 1951

Variations for Tongue Disease

ClinVar genetic disease variations for Tongue Disease:

6 ‎‎ ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 TP53 NM_000546.5(TP53):c.742C>T (p.Arg248Trp)SNV Pathogenic 12347 rs121912651 17:7577539-7577539 17:7674221-7674221
2 DNAJC21 NM_001012339.3(DNAJC21):c.544C>T (p.Arg182Ter)SNV Pathogenic 598950 5:34937536-34937536 5:34937431-34937431
3 46;XY;t(3;17)(p14.3;q24.3)dnTranslocation Likely pathogenic 267799
4 SOX3 NM_005634.2(SOX3):c.735_737dup (p.Ala248dup)duplication Uncertain significance 95305 rs398124211 X:139586489-139586491 X:140504324-140504326

Expression for Tongue Disease

Search GEO for disease gene expression data for Tongue Disease.

Pathways for Tongue Disease

GO Terms for Tongue Disease

Cellular components related to Tongue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.28 MIR486-1 MIR30A MIR21 MIR199A1 MIR18A MIR186

Biological processes related to Tongue Disease according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor signaling pathway GO:0007179 9.65 TP53 MIR30A MIR21
2 negative regulation of gene expression GO:0010629 9.65 TP53 MIR33A MIR21 MIR181A1 MIR17
3 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.55 MIR21 MIR17
4 negative regulation of cardiac muscle hypertrophy GO:0010614 9.54 MIR21 MIR145
5 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.52 MIR199A1 MIR17
6 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.51 MIR21 MIR181A1
7 negative regulation of cardiac muscle cell apoptotic process GO:0010667 9.5 MIR21 MIR199A1 MIR145
8 cell growth involved in cardiac muscle cell development GO:0061049 9.49 MIR199A1 MIR195
9 positive regulation of connective tissue replacement GO:1905205 9.46 MIR199A1 MIR195
10 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.43 MIR199A1 MIR17
11 miRNA mediated inhibition of translation GO:0035278 9.43 MIR483 MIR30A MIR21 MIR181A1 MIR17 MIR145
12 positive regulation of metalloendopeptidase activity GO:1904685 9.4 MIR21 MIR17
13 gene silencing by miRNA GO:0035195 9.4 MIR491 MIR483 MIR33A MIR30A MIR21 MIR199A1
14 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.37 MIR21 MIR17
15 positive regulation of cardiac muscle cell apoptotic process GO:0010666 9.33 TP53 MIR195 MIR17

Molecular functions related to Tongue Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.4 MIR491 MIR483 MIR33A MIR30A MIR21 MIR199A1
2 RNA polymerase II complex binding GO:0000993 9.13 MIR33A MIR145 MIR139

Sources for Tongue Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....