Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: TNG009
MIFTS: 48

Tongue Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Tongue Squamous Cell Carcinoma

About this section

MalaCards integrated aliases for Tongue Squamous Cell Carcinoma:

Name: Tongue Squamous Cell Carcinoma 39 12 15 17
Squamous Cell Carcinoma of Tongue 74

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Oral diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050865
NCIt 51 C4648
UMLS 74 C0349566
Sources

Summaries for Tongue Squamous Cell Carcinoma

About this section
Disease Ontology : 12 A head and neck squamous cell carcinoma that is located in the tongue.

MalaCards based summary : Tongue Squamous Cell Carcinoma, also known as squamous cell carcinoma of tongue, is related to squamous cell carcinoma and tongue cancer. An important gene associated with Tongue Squamous Cell Carcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways are Development EGFR signaling pathway and Proteoglycans in cancer. The drugs Cetuximab and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include the tongue, tongue and lymph node.

Sources

Related Diseases for Tongue Squamous Cell Carcinoma

About this section

Diseases related to Tongue Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 31.9 CDH1 LINC01503 MALAT1 MMP2 TP53 UCA1
2 tongue cancer 30.3 CASP3 CDH1 MALAT1 MMP2 TP53
3 thyroid cancer, nonmedullary, 1 29.9 HOTTIP MALAT1 MEG3 MIR222
4 thyroid cancer 29.8 AFAP1-AS1 CASP3 CDH1 MALAT1 TP53 UCA1
5 cervical cancer 29.6 CASP3 CDH1 MALAT1 MEG3 MIR21 MMP2
6 nasopharyngeal carcinoma 29.5 AFAP1-AS1 CASP3 CDH1 MALAT1 MEG3 NKILA
7 short-rib thoracic dysplasia 4 with or without polydactyly 10.5 CASP3 TP53
8 male reproductive system disease 10.5 CASP3 CDH1 TP53
9 vulvar intraepithelial neoplasia 10.5 MMP2 TP53
10 cerebral convexity meningioma 10.5 CDH1 TP53
11 supratentorial cancer 10.4 CASP3 MMP2 TP53
12 cerebrum cancer 10.4 CASP3 MMP2 TP53
13 nasopharyngeal disease 10.4 CASP3 CDH1 TP53
14 laryngeal disease 10.4 CDH1 MMP2 TP53
15 skin melanoma 10.4 CASP3 MMP2 TP53
16 ovarian cancer 1 10.4 CDH1 MMP2 TP53
17 malignant ovarian surface epithelial-stromal neoplasm 10.4 CDH1 MMP2 TP53
18 ovary epithelial cancer 10.4 CDH1 MMP2 TP53
19 pharynx cancer 10.4 CASP3 CDH1 TP53
20 esophagus adenocarcinoma 10.4 AFAP1-AS1 MIR21 TP53
21 hypoxia 10.4
22 cervix disease 10.4 CASP3 CDH1 TP53
23 uterine anomalies 10.4 CASP3 CDH1 TP53
24 polymyositis 10.4 MIR21 MIR222
25 male reproductive organ cancer 10.4 CASP3 CDH1 TP53
26 colonic disease 10.4 CASP3 CDH1 TP53
27 female reproductive system disease 10.4 CASP3 CDH1 MMP2 TP53
28 stomach disease 10.4 CASP3 CDH1 TP53
29 reproductive system disease 10.4 CASP3 CDH1 MMP2 TP53
30 bladder disease 10.4 CDH1 TP53 UCA1
31 endocrine gland cancer 10.4 CASP3 CDH1 MMP2 TP53
32 gastrointestinal system disease 10.4 CASP3 CDH1 MMP2 TP53
33 intestinal disease 10.4 CASP3 CDH1 TP53
34 tongue disease 10.4 CDH1 LINC01527 MMP2 TP53
35 respiratory system disease 10.3 CASP3 CDH1 TP53
36 oral cancer 10.3 CASP3 CDH1 MIR21 MMP2 TP53
37 esophagus squamous cell carcinoma 10.3 AFAP1-AS1 MEG3
38 larynx cancer 10.3 MIR21 MMP2 TP53
39 sarcomatoid renal cell carcinoma 10.3 CDH1 TP53
40 pancreas adenocarcinoma 10.2 CASP3 CDH1 TP53
41 large intestine cancer 10.2 CASP3 CDH1 MMP2 TP53
42 gastric adenocarcinoma 10.2 CASP3 CDH1 MMP2 TP53
43 squamous cell carcinoma, head and neck 10.2 CASP3 CDH1 CYTOR MIR21 MMP2 TP53
44 laryngeal squamous cell carcinoma 10.2 CDH1 MALAT1 MIR21 TP53
45 vulva squamous cell carcinoma 10.2 MALAT1 MEG3 TP53
46 ovarian epithelial cancer 10.1 MALAT1 MEG3
47 small cell cancer of the lung 10.1 HOTTIP MALAT1 MIR21 TP53
48 respiratory system cancer 10.1 CASP3 CDH1 MALAT1 MMP2 TP53
49 gastrointestinal system cancer 10.1 CASP3 CDH1 MALAT1 MMP2 TP53
50 headache associated with sexual activity 10.1

Graphical network of the top 20 diseases related to Tongue Squamous Cell Carcinoma:



Diseases related to Tongue Squamous Cell Carcinoma
Sources

Symptoms & Phenotypes for Tongue Squamous Cell Carcinoma

About this section
Sources

Drugs & Therapeutics for Tongue Squamous Cell Carcinoma

About this section

Drugs for Tongue Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
2
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
3
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
4
Fluorouracil Approved Phase 2 51-21-8 3385
5
nivolumab Approved Phase 2 946414-94-4
6
Ipilimumab Approved Phase 2 477202-00-9
7 Antineoplastic Agents, Immunological Phase 1, Phase 2,Phase 2
8 Antimitotic Agents Phase 2
9 Anesthetics Phase 2,Not Applicable
10 Antibodies, Monoclonal Phase 2
11 Immunoglobulins Phase 2
12 Antibodies Phase 2
13
Ribavirin Approved Not Applicable 36791-04-5 37542
14 Hemostatics Not Applicable
15 Antimetabolites Not Applicable
16 Anti-Infective Agents Not Applicable
17 Antiviral Agents Not Applicable
18
Luteolin Early Phase 1 491-70-3 5280445

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment in Locally Advanced Tongue Cancer ; A NEW PARADIGM OF TREATMENT Unknown status NCT01760811 Phase 1, Phase 2 Erbitux,merck serono
2 Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue Unknown status NCT02985255 Phase 2 Docetaxel;Cisplatin;5FU
3 Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma Not yet recruiting NCT03799445 Phase 2
4 Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva Unknown status NCT00426062
5 Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma Recruiting NCT03440151 Not Applicable
6 Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 Not Applicable ribavirin
7 Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line Not yet recruiting NCT03288298 Early Phase 1 luteolin;nano-luteolin

Search NIH Clinical Center for Tongue Squamous Cell Carcinoma

Sources

Genetic Tests for Tongue Squamous Cell Carcinoma

About this section
Sources

Anatomical Context for Tongue Squamous Cell Carcinoma

About this section

The Foundational Model of Anatomy Ontology organs/tissues related to Tongue Squamous Cell Carcinoma:

20
The Tongue

MalaCards organs/tissues related to Tongue Squamous Cell Carcinoma:

42
Tongue, Lymph Node, Endothelial, T Cells, Tonsil, Thyroid, Skeletal Muscle
Sources

Publications for Tongue Squamous Cell Carcinoma

About this section

Articles related to Tongue Squamous Cell Carcinoma:

(show top 50) (show all 551)
# Title Authors Year
1
R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling. ( 31097406 )
2019
2
Prognostic Value of Cervical Nodal Necrosis Observed in Preoperative CT and MRI of Patients With Tongue Squamous Cell Carcinoma and Cervical Node Metastases: A Retrospective Study. ( 31039018 )
2019
3
FSCN1 is an effective marker of poor prognosis and a potential therapeutic target in human tongue squamous cell carcinoma. ( 31043585 )
2019
4
KRAS mutations in tongue squamous cell carcinoma. ( 31066593 )
2019
5
Non-curative treatment of patients with oral tongue squamous-cell carcinoma. ( 31069467 )
2019
6
Gene regulation analysis of the effects of evodiamine on tongue squamous cell carcinoma. ( 31081147 )
2019
7
Deep Convolutional Neural Networks for Tongue Squamous Cell Carcinoma Classification Using Raman Spectroscopy. ( 31082525 )
2019
8
LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600/EZH2 axis. ( 30970517 )
2019
9
Differential clinical significance of COL5A1 and COL5A2 in tongue squamous cell carcinoma. ( 30972812 )
2019
10
Survival of oral tongue squamous cell carcinoma in young adults. ( 30985036 )
2019
11
Correction: Simultaneous Expression of Furin and Vascular Endothelial Growth Factor in Human Oral Tongue Squamous Cell Carcinoma Progression. ( 30988097 )
2019
12
Xenotropic and polytropic retrovirus receptor 1 (XPR1) promotes progression of tongue squamous cell carcinoma (TSCC) via activation of NF-κB signaling. ( 30995931 )
2019
13
Prognostic value of immunoexpression of CCR4, CCR5, CCR7 and CXCR4 in squamous cell carcinoma of tongue and floor of the mouth. ( 31011147 )
2019
14
Validation of the International Tumor Budding Consensus Conference (ITBCC 2016) Recommendations in Oral Tongue Squamous Cell Carcinoma. ( 30927486 )
2019
15
Hsa_circ_0001742 promotes tongue squamous cell carcinoma progression via modulating miR-634 expression. ( 30944081 )
2019
16
High expression of FMNL3 associates with cancer cell migration, invasion, and unfavorable prognosis in tongue squamous cell carcinoma. ( 30955218 )
2019
17
Long noncoding RNA LINC00961 inhibited cell proliferation and invasion through regulating the Wnt/β-catenin signaling pathway in tongue squamous cell carcinoma. ( 30854692 )
2019
18
lncRNA MALAT1 potentiates the progression of tongue squamous cell carcinoma through regulating miR-140-5p-PAK1 pathway. ( 30863103 )
2019
19
Multi-parametric effect in predicting tumor histological grade by using susceptibility weighted magnetic resonance imaging in tongue squamous cell carcinoma. ( 30866854 )
2019
20
The use of carbon nanoparticles to track occult lingual lymph nodes in early-stage tongue squamous cell carcinoma. ( 30876796 )
2019
21
Comprehensive analysis of lncRNA-associated competing endogenous RNA network in tongue squamous cell carcinoma. ( 30755833 )
2019
22
TLR5 and TLR7 are differentially expressed in human papillomavirus-positive and negative base of tongue squamous cell carcinoma, and TLR7 may have an independent prognostic influence. ( 30794027 )
2019
23
lncRNA RP5-916L7.2 correlates with advanced tumor stage, and promotes cells proliferation while inhibits cells apoptosis through targeting miR-328 and miR-939 in tongue squamous cell carcinoma. ( 30825424 )
2019
24
Integrative analysis of gene expression profiles reveals distinct molecular characteristics in oral tongue squamous cell carcinoma. ( 30675303 )
2019
25
Evaluation of Liquid Based Cytology for Tongue Squamous Cell Carcinoma: Comparison with Conventional Cytology. ( 30700642 )
2019
26
Wnt7a predicts poor prognosis, and contributes to growth and metastasis in tongue squamous cell carcinoma. ( 30747225 )
2019
27
MicroRNA‑758 inhibits tumorous behavior in tongue squamous cell carcinoma by directly targeting metadherin. ( 30628702 )
2019
28
Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma. ( 30633412 )
2019
29
Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes. ( 30633435 )
2019
30
LncRNA MALAT1 expression inhibition suppresses tongue squamous cell carcinoma proliferation, migration and invasion by inactivating PI3K/Akt pathway and downregulating MMP-9 expression. ( 30657561 )
2019
31
Carcinoembryonic antigen cell adhesion molecule 1 inhibits the antitumor effect of neutrophils in tongue squamous cell carcinoma. ( 30565803 )
2019
32
Mitochondrial DNA variations in tongue squamous cell carcinoma. ( 30588299 )
2019
33
A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching. ( 30515671 )
2019
34
Corrigendum to "Odd-skipped related transcription factor 1 (OSR1) suppresses tongue squamous cell carcinoma migration and invasion through inhibiting NF-κB pathway" [Eur. J. Pharmacol. 15 (2018) 33-39]. ( 30529035 )
2019
35
Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma. ( 30537401 )
2019
36
Outcomes after up-front surgery and metronomic neoadjuvant chemotherapy with S-1 or UFT for early tongue squamous cell carcinoma. ( 30317400 )
2019
37
High expression of TMEM40 contributes to progressive features of tongue squamous cell carcinoma. ( 30320346 )
2019
38
CRNDE promotes cell tongue squamous cell carcinoma cell growth and invasion through suppressing miR-384. ( 30242873 )
2019
39
FGF-2 and FGFR-1 might be independent prognostic factors in oral tongue squamous cell carcinoma. ( 30129658 )
2019
40
Utility of intraoral ultrasound in managing oral tongue squamous cell carcinoma: Systematic review. ( 30151976 )
2019
41
Clinical Implications of Tumor-Associated Tissue Eosinophilia in Tongue Squamous Cell Carcinoma. ( 30098046 )
2019
42
H19 Facilitates Tongue Squamous Cell Carcinoma Migration and Invasion via Sponging miR-let-7. ( 29523225 )
2019
43
Data on the aquaporin gene expression differences among ρ0, clinically relevant radioresistant, and the parental cells of human cervical cancer and human tongue squamous cell carcinoma. ( 30175205 )
2018
44
Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia. ( 29682563 )
2018
45
Free flap reconstruction for early stage tongue squamous cell carcinoma: surgical margin and recurrence. ( 30676880 )
2018
46
An Unusual Case of Tertiary Syphilis Behaving Like Tongue Squamous Cell Carcinoma. ( 30622992 )
2018
47
Oral tongue squamous cell carcinoma survival as stratified by age and sex: A surveillance, epidemiology, and end results analysis. ( 30575045 )
2018
48
Nox4 Overexpression as a Poor Prognostic Factor in Patients with Oral Tongue Squamous Cell Carcinoma Receiving Surgical Resection. ( 30513726 )
2018
49
Inactivation of RUNX3 protein expression in tongue squamous cell carcinoma and its association with clinicopathological characteristics. ( 30535462 )
2018
50
Tumor budding and adjacent tissue at the invasive front correlate with delayed neck metastasis in clinical early-stage tongue squamous cell carcinoma. ( 30548537 )
2018
Sources

Variations for Tongue Squamous Cell Carcinoma

About this section

Cosmic variations for Tongue Squamous Cell Carcinoma:

9 (show top 50) (show all 202)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6957917 TSC2 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1120A>T p.T374S 16:2061871-2061871 0
2 COSM10771 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.749C>T p.P250L 17:7674214-7674214 0
3 COSM10663 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 0
4 COSM10656 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 0
5 COSM10724 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 0
6 COSM43680 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 0
7 COSM10660 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 0
8 COSM10867 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 0
9 COSM43903 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.470T>G p.V157G 17:7675142-7675142 0
10 COSM10726 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 0
11 COSM44393 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.821T>C p.V274A 17:7673799-7673799 0
12 COSM10704 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 0
13 COSM43814 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.587G>C p.R196P 17:7674944-7674944 0
14 COSM10662 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 0
15 COSM43963 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 0
16 COSM10648 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 0
17 COSM43747 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.872A>G p.K291R 17:7673748-7673748 0
18 COSM43841 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.560-1G>T p.? 17:7674972-7674972 0
19 COSM6932 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 0
20 COSM43947 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 0
21 COSM44424 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.590T>A p.V197E 17:7674941-7674941 0
22 COSM10654 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 0
23 COSM11450 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.644G>T p.S215I 17:7674887-7674887 0
24 COSM44785 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.702C>G p.Y234* 17:7674261-7674261 0
25 COSM11196 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.734G>T p.G245V 17:7674229-7674229 0
26 COSM44567 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.647T>C p.V216A 17:7674884-7674884 0
27 COSM44411 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.608T>A p.V203E 17:7674923-7674923 0
28 COSM10834 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.711G>A p.M237I 17:7674252-7674252 0
29 COSM43621 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.809T>G p.F270C 17:7673811-7673811 0
30 COSM44351 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.572C>T p.P191L 17:7674959-7674959 0
31 COSM11073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 0
32 COSM44262 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.808T>C p.F270L 17:7673812-7673812 0
33 COSM45132 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.783-2A>G p.? 17:7673839-7673839 0
34 COSM43695 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.748C>T p.P250S 17:7674215-7674215 0
35 COSM44523 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.863A>G p.N288S 17:7673757-7673757 0
36 COSM45135 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.673-1G>T p.? 17:7674291-7674291 0
37 COSM10859 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.814G>T p.V272L 17:7673806-7673806 0
38 COSM43708 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 17:7675190-7675190 0
39 COSM11066 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>T p.H193L 17:7674953-7674953 0
40 COSM10992 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>G p.R282G 17:7673776-7673776 0
41 COSM10739 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.481G>A p.A161T 17:7675131-7675131 0
42 COSM11147 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.370T>C p.C124R 17:7675999-7675999 0
43 COSM10790 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.455C>T p.P152L 17:7675157-7675157 0
44 COSM44073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.374C>A p.T125K 17:7675995-7675995 0
45 COSM10939 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.832C>T p.P278S 17:7673788-7673788 0
46 COSM10645 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 0
47 COSM10687 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>A p.C176Y 17:7675085-7675085 0
48 COSM10905 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 0
49 COSM10727 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.438G>A p.W146* 17:7675174-7675174 0
50 COSM43833 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>C p.H193P 17:7674953-7674953 0
Sources

Expression for Tongue Squamous Cell Carcinoma

About this section
LifeMap Discovery
Genes differentially expressed in tissues of Tongue Squamous Cell Carcinoma patients vs. healthy controls: 35 (show all 30)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 MMP1 matrix metallopeptidase 1 Oral Cavity + 6.95 0.000
2 TMPRSS11B transmembrane protease, serine 11B Oral Cavity - 5.73 0.000
3 MAL mal, T-cell differentiation protein Oral Cavity - 5.07 0.000
4 CRNN cornulin Oral Cavity - 4.97 0.000
5 KRT13 keratin 13, type I Oral Cavity - 4.67 0.001
6 MYH2 myosin, heavy chain 2, skeletal muscle, adult Oral Cavity - 4.12 0.005
7 PTHLH parathyroid hormone-like hormone Oral Cavity + 4.09 0.000
8 KRT17 keratin 17, type I Oral Cavity + 3.76 0.000
9 CXCL12 chemokine (C-X-C motif) ligand 12 Oral Cavity - 3.73 0.000
10 LAMC2 laminin, gamma 2 Oral Cavity + 3.68 0.000
11 CLCA4 chloride channel accessory 4 Oral Cavity - 3.65 0.000
12 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Oral Cavity + 3.44 0.000
13 LDB3 LIM domain binding 3 Oral Cavity - 3.41 0.003
14 MMP3 matrix metallopeptidase 3 Oral Cavity + 3.39 0.000
15 CLU clusterin Oral Cavity - 3.38 0.000
16 WDR66 WD repeat domain 66 Oral Cavity + 3.37 0.000
17 GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 Oral Cavity - 3.36 0.000
18 PRR9 proline rich 9 Oral Cavity + 3.34 0.004
19 CXCL8 chemokine (C-X-C motif) ligand 8 Oral Cavity + 3.33 0.000
20 CRISP3 cysteine-rich secretory protein 3 Oral Cavity - 3.23 0.010
21 CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 Oral Cavity - 3.21 0.000
22 SPINK5 serine peptidase inhibitor, Kazal type 5 Oral Cavity - 3.20 0.002
23 S100A7A S100 calcium binding protein A7A Oral Cavity + 3.15 0.001
24 IFI6 interferon, alpha-inducible protein 6 Oral Cavity + 3.13 0.000
25 INHBA inhibin, beta A Oral Cavity + 3.13 0.001
26 KRT4 keratin 4, type II Oral Cavity - 3.11 0.000
27 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 Oral Cavity - 3.10 0.000
28 FAM3B family with sequence similarity 3, member B Oral Cavity - 3.08 0.007
29 EPPK1 epiplakin 1 Oral Cavity + 3.07 0.000
30 SPRR3 small proline-rich protein 3 Oral Cavity - 3.06 0.025
Search GEO for disease gene expression data for Tongue Squamous Cell Carcinoma.
Sources

Pathways for Tongue Squamous Cell Carcinoma

About this section

Pathways related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development EGFR signaling pathway 23
Show member pathways
 12.15 CASP3 CDH1 MMP2 TP53
2
Proteoglycans in cancer 38
11.86 CASP3 MIR21 MMP2 TP53
3
MicroRNAs in cancer 38
11.83 CASP3 MIR133B MIR21 MIR222 TP53
4
Colorectal Cancer Metastasis 65
11.67 CASP3 CDH1 MMP2 TP53
5
Bladder cancer 1 38
11.36 CDH1 MMP2 TP53
6
LncRNA-mediated mechanisms of therapeutic resistance 1
9.88 MEG3 TP53 UCA1
Sources

GO Terms for Tongue Squamous Cell Carcinoma

About this section

Biological processes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA mediated inhibition of translation GO:0035278 9.13 MIR133B MIR21 MIR222
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.8 MIR21 MIR222 MMP2
Sources

Sources for Tongue Squamous Cell Carcinoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....