MCID: TNG009
MIFTS: 44

Tongue Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Tongue Squamous Cell Carcinoma

MalaCards integrated aliases for Tongue Squamous Cell Carcinoma:

Name: Tongue Squamous Cell Carcinoma 12 15 17
Squamous Cell Carcinoma of Tongue 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0050865
NCIt 50 C4648
UMLS 72 C0349566

Summaries for Tongue Squamous Cell Carcinoma

Disease Ontology : 12 A head and neck squamous cell carcinoma that is located in the tongue.

MalaCards based summary : Tongue Squamous Cell Carcinoma, also known as squamous cell carcinoma of tongue, is related to squamous cell carcinoma and oral cancer. An important gene associated with Tongue Squamous Cell Carcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways are Proteoglycans in cancer and MicroRNAs in cancer. The drugs Cetuximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include tongue, lymph node and endothelial.

Related Diseases for Tongue Squamous Cell Carcinoma

Diseases related to Tongue Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 117)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 31.9 UCA1 TP53 MMP2 MALAT1 LINC01503 CDH1
2 oral cancer 31.9 TP53 MMP2 MIR21 CDH1 CASP3
3 tongue cancer 31.7 TP53 MMP2 MALAT1 CDH1 CASP3
4 oral squamous cell carcinoma 31.2 UCA1 MIR21 MEG3 MALAT1
5 tongue disease 31.0 TP53 MMP2 LINC01527 CDH1
6 squamous cell carcinoma, head and neck 30.6 TP53 MMP2 MIR21 CYTOR CDH1 CASP3
7 thyroid cancer, nonmedullary, 1 30.0 MIR222 MEG3 MALAT1 HOTTIP
8 renal cell carcinoma, nonpapillary 29.9 UCA1 MMP2 MALAT1 CYTOR CDH1
9 cervical cancer 29.7 UCA1 TP53 MMP2 MIR21 MEG3 MALAT1
10 lung cancer susceptibility 3 28.8 TP53 MMP2 MEG3 MALAT1 CYTOR CDH1
11 nasopharyngeal carcinoma 28.7 TP53 NKILA MEG3 MALAT1 CDH1 CASP3
12 short-rib thoracic dysplasia 4 with or without polydactyly 10.8 TP53 CASP3
13 male reproductive system disease 10.8 TP53 CDH1 CASP3
14 vulvar intraepithelial neoplasia 10.7 TP53 MMP2
15 cerebral convexity meningioma 10.7 TP53 CDH1
16 cerebrum cancer 10.7 TP53 MMP2 CASP3
17 supratentorial cancer 10.7 TP53 MMP2 CASP3
18 skin melanoma 10.7 TP53 MMP2 CASP3
19 laryngeal disease 10.7 TP53 MMP2 CDH1
20 nasopharyngeal disease 10.7 TP53 CDH1 CASP3
21 ovary epithelial cancer 10.7 TP53 MMP2 CDH1
22 malignant ovarian surface epithelial-stromal neoplasm 10.7 TP53 MMP2 CDH1
23 ovarian cancer 1 10.7 TP53 MMP2 CDH1
24 pharynx cancer 10.7 TP53 CDH1 CASP3
25 cervix disease 10.7 TP53 CDH1 CASP3
26 uterine anomalies 10.7 TP53 CDH1 CASP3
27 colonic disease 10.7 TP53 CDH1 CASP3
28 male reproductive organ cancer 10.6 TP53 CDH1 CASP3
29 female reproductive system disease 10.6 TP53 MMP2 CDH1 CASP3
30 reproductive system disease 10.6 TP53 MMP2 CDH1 CASP3
31 polymyositis 10.6 MIR222 MIR21
32 stomach disease 10.6 TP53 CDH1 CASP3
33 endocrine gland cancer 10.6 TP53 MMP2 CDH1 CASP3
34 bladder disease 10.6 UCA1 TP53 CDH1
35 gastrointestinal system disease 10.6 TP53 MMP2 CDH1 CASP3
36 intestinal disease 10.6 TP53 CDH1 CASP3
37 respiratory system disease 10.5 TP53 CDH1 CASP3
38 larynx cancer 10.5 TP53 MMP2 MIR21
39 obsolete: squamous cell carcinoma of head and neck 10.4
40 sarcomatoid renal cell carcinoma 10.4 TP53 CDH1
41 large intestine cancer 10.4 TP53 MMP2 CDH1 CASP3
42 b-cell lymphoma 10.3
43 esophagus adenocarcinoma 10.3 TP53 MIR21 AFAP1-AS1
44 squamous cell papilloma 10.3
45 papilloma 10.3
46 gastric adenocarcinoma 10.3 TP53 MMP2 CDH1 CASP3
47 vulva squamous cell carcinoma 10.3 TP53 MEG3 MALAT1
48 laryngeal squamous cell carcinoma 10.3 TP53 MIR21 MALAT1 CDH1
49 oral cavity cancer 10.3
50 leukoplakia 10.3

Graphical network of the top 20 diseases related to Tongue Squamous Cell Carcinoma:



Diseases related to Tongue Squamous Cell Carcinoma

Symptoms & Phenotypes for Tongue Squamous Cell Carcinoma

Drugs & Therapeutics for Tongue Squamous Cell Carcinoma

Drugs for Tongue Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
2 Antineoplastic Agents, Immunological Phase 1, Phase 2
3
Ribavirin Approved 36791-04-5 37542
4 Hemostatics
5 Anesthetics
6 Antimetabolites
7 Antiviral Agents
8 Anti-Infective Agents
9
Luteolin Early Phase 1 491-70-3 5280445

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment Followed by 6 Weeks of Cetuximab+RT Post Surgery in Locally Advanced Squamous Cell Carcinoma of the Tongue ; A NEW PARADIGM OF TREATMENT Unknown status NCT01760811 Phase 1, Phase 2 Erbitux,merck serono
2 Bayesian Phase II Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer Recruiting NCT03224000 Phase 2
3 Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva Unknown status NCT00426062
4 Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma (Randomize Noninferiority Clinical Trial) Recruiting NCT03440151
5 A Pilot Study to Assess the Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 ribavirin
6 Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line: In Vitro Study Not yet recruiting NCT03288298 Early Phase 1 luteolin;nano-luteolin

Search NIH Clinical Center for Tongue Squamous Cell Carcinoma

Genetic Tests for Tongue Squamous Cell Carcinoma

Anatomical Context for Tongue Squamous Cell Carcinoma

MalaCards organs/tissues related to Tongue Squamous Cell Carcinoma:

41
Tongue, Lymph Node, Endothelial, T Cells, Tonsil, Skeletal Muscle, Bone

The Foundational Model of Anatomy Ontology organs/tissues related to Tongue Squamous Cell Carcinoma:

19
Tongue

Publications for Tongue Squamous Cell Carcinoma

Articles related to Tongue Squamous Cell Carcinoma:

(show top 50) (show all 1093)
# Title Authors PMID Year
1
MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines. 38 88
19487542 2009
2
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. 38 88
18464261 2008
3
MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. 88
19509158 2009
4
Survival of oral tongue squamous cell carcinoma in young adults. 38
30985036 2019
5
Gene regulation analysis of the effects of evodiamine on tongue squamous cell carcinoma. 38
31081147 2019
6
The use of carbon nanoparticles to track occult lingual lymph nodes in early-stage tongue squamous cell carcinoma. 38
30876796 2019
7
Oral tongue squamous cell carcinoma survival as stratified by age and sex: A surveillance, epidemiology, and end results analysis. 38
30575045 2019
8
Cancer associated fibroblasts are distinguishable from peri-tumor fibroblasts by biological characteristics in TSCC. 38
31404347 2019
9
miR-611 promotes the proliferation, migration, and invasion of tongue squamous cell carcinoma cells by targeting FOXN3. 38
31419344 2019
10
Prognostic Value of Cervical Nodal Necrosis Observed in Preoperative CT and MRI of Patients With Tongue Squamous Cell Carcinoma and Cervical Node Metastases: A Retrospective Study. 38
31039018 2019
11
Long noncoding RNA LINC00961 inhibited cell proliferation and invasion through regulating the Wnt/β-catenin signaling pathway in tongue squamous cell carcinoma. 38
30854692 2019
12
Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma. 38
31411752 2019
13
The HSP90/AKT pathway may mediate artemether-induced apoptosis of Cal27 cells. 38
31376209 2019
14
The in vitro and in vivo antitumor effects of Dracaena cinnabari resin extract on oral cancer. 38
31176147 2019
15
Evaluation of early oral cavity cancer treatment quality at a single institution. 38
30408196 2019
16
Machine learning application for prediction of locoregional recurrences in early oral tongue cancer: a Web-based prognostic tool. 38
31422502 2019
17
The role of the T-N tract in advanced stage tongue cancer. 38
30942940 2019
18
Sentinel Lymph Node-Targeted Therapy by Oncolytic Sendai Virus Suppresses Micrometastasis of Head and Neck Squamous Cell Carcinoma in an Orthotopic Nude Mouse Model. 38
31171582 2019
19
Establishment of syngeneic murine model for oral cancer therapy. 38
31345390 2019
20
Oral squamous cell carcinoma of tongue: Histological risk assessment. A pilot study. 38
31422411 2019
21
Integrated analysis of lncRNA-miRNA-mRNA ceRNA network in squamous cell carcinoma of tongue. 38
31391008 2019
22
Assessment of Tumor-infiltrating Lymphocytes Predicts the Behavior of Early-stage Oral Tongue Cancer. 38
31290758 2019
23
Hypermethylation of DcR1, DcR2, DR4, DR5 gene promoters and clinical significance in tongue carcinoma. 38
31399243 2019
24
Association of SP1 rs1353058818 and STAT3 rs1053004 gene polymorphisms with human tongue squamous cell carcinoma. 38
31270251 2019
25
Validation of the International Tumor Budding Consensus Conference (2016) recommendations in oral tongue squamous cell carcinoma. 38
30927486 2019
26
Differential clinical significance of COL5A1 and COL5A2 in tongue squamous cell carcinoma. 38
30972812 2019
27
KRAS mutations in tongue squamous cell carcinoma. 38
31066593 2019
28
Non-curative treatment of patients with oral tongue squamous-cell carcinoma. 38
31069467 2019
29
The growth inhibitory effect of human gingiva-derived mesenchymal stromal cells expressing interferon-β on tongue squamous cell carcinoma cells and xenograft model. 38
31358054 2019
30
Suppression of the long non-coding RNA MALAT-1 impairs the growth and migration of human tongue squamous cell carcinoma SCC4 cells. 38
31360193 2019
31
The role of MRI-derived depth of invasion in staging oral tongue squamous cell carcinoma: inter-reader and radiological-pathological agreement. 38
31319692 2019
32
Can pattern and depth of invasion predict lymph node relapse and prognosis in tongue squamous cell carcinoma. 38
31324174 2019
33
Long noncoding RNA FALEC inhibits proliferation and metastasis of tongue squamous cell carcinoma by epigenetically silencing ECM1 through EZH2. 38
31335317 2019
34
Computer-assisted image analysis of the tumor microenvironment on an oral tongue squamous cell carcinoma tissue microarray. 38
31193592 2019
35
High expression of FMNL3 associates with cancer cell migration, invasion, and unfavorable prognosis in tongue squamous cell carcinoma. 38
30955218 2019
36
MiR-940 inhibits migration and invasion of tongue squamous cell carcinoma via regulatingCXCR2/NF-κB system-mediated epithelial-mesenchymal transition. 38
31214736 2019
37
Outcomes after up-front surgery and metronomic neoadjuvant chemotherapy with S-1 or UFT for early tongue squamous cell carcinoma. 38
30317400 2019
38
R-spondin 2-LGR4 system regulates growth, migration and invasion, epithelial-mesenchymal transition and stem-like properties of tongue squamous cell carcinoma via Wnt/β-catenin signaling. 38
31097406 2019
39
Long non-coding RNA myocardial infarction associated transcript promotes epithelial-mesenchymal transition and is an independent risk factor for poor prognosis of tongue squamous cell carcinoma. 38
31166624 2019
40
Nomograms to predict survival of stage IV tongue squamous cell carcinoma after surgery. 38
31261568 2019
41
Distant metastases in newly diagnosed tongue squamous cell carcinoma. 38
31206925 2019
42
Understanding the role of the R-spondin 2-LGR4 system in tongue squamous cell carcinoma progression. 38
31122842 2019
43
Deep convolutional neural networks for tongue squamous cell carcinoma classification using Raman spectroscopy. 38
31082525 2019
44
Importance of tumor budding grade as independent prognostic factor for early tongue squamous cell carcinoma. 38
30633412 2019
45
Early onset oral tongue squamous cell carcinoma: Associated factors and patient outcomes. 38
30633435 2019
46
Surgical treatment of early tongue squamous cell carcinoma and patient survival. 38
31186792 2019
47
Retraction Note: Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/β-catenin signaling pathway. 38
31153369 2019
48
Prognostic factors, failure patterns and survival analysis in patients with resectable oral squamous cell carcinoma of the tongue. 38
31266288 2019
49
World Workshop on Oral Medicine VII: Clinical evidence of differential expression of lncRNAs in oral squamous cell carcinoma: A scoping review. 38
31140697 2019
50
LncRNA THOR promotes tongue squamous cell carcinomas by stabilizing IGF2BP1 downstream targets. 38
31220513 2019

Variations for Tongue Squamous Cell Carcinoma

Cosmic variations for Tongue Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM5881369 NOTCH1 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.6435C>G p.Y2145* 9:136497304-136497304 0

Expression for Tongue Squamous Cell Carcinoma

LifeMap Discovery
Genes differentially expressed in tissues of Tongue Squamous Cell Carcinoma patients vs. healthy controls: 35 (show all 30)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 MMP1 matrix metallopeptidase 1 Oral Cavity + 6.95 0.000
2 TMPRSS11B transmembrane protease, serine 11B Oral Cavity - 5.73 0.000
3 MAL mal, T-cell differentiation protein Oral Cavity - 5.07 0.000
4 CRNN cornulin Oral Cavity - 4.97 0.000
5 KRT13 keratin 13, type I Oral Cavity - 4.67 0.001
6 MYH2 myosin, heavy chain 2, skeletal muscle, adult Oral Cavity - 4.12 0.005
7 PTHLH parathyroid hormone-like hormone Oral Cavity + 4.09 0.000
8 KRT17 keratin 17, type I Oral Cavity + 3.76 0.000
9 CXCL12 chemokine (C-X-C motif) ligand 12 Oral Cavity - 3.73 0.000
10 LAMC2 laminin, gamma 2 Oral Cavity + 3.68 0.000
11 CLCA4 chloride channel accessory 4 Oral Cavity - 3.65 0.000
12 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Oral Cavity + 3.44 0.000
13 LDB3 LIM domain binding 3 Oral Cavity - 3.41 0.003
14 MMP3 matrix metallopeptidase 3 Oral Cavity + 3.39 0.000
15 CLU clusterin Oral Cavity - 3.38 0.000
16 WDR66 WD repeat domain 66 Oral Cavity + 3.37 0.000
17 GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 Oral Cavity - 3.36 0.000
18 PRR9 proline rich 9 Oral Cavity + 3.34 0.004
19 CXCL8 chemokine (C-X-C motif) ligand 8 Oral Cavity + 3.33 0.000
20 CRISP3 cysteine-rich secretory protein 3 Oral Cavity - 3.23 0.010
21 CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 Oral Cavity - 3.21 0.000
22 SPINK5 serine peptidase inhibitor, Kazal type 5 Oral Cavity - 3.20 0.002
23 S100A7A S100 calcium binding protein A7A Oral Cavity + 3.15 0.001
24 IFI6 interferon, alpha-inducible protein 6 Oral Cavity + 3.13 0.000
25 INHBA inhibin, beta A Oral Cavity + 3.13 0.001
26 KRT4 keratin 4, type II Oral Cavity - 3.11 0.000
27 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 Oral Cavity - 3.10 0.000
28 FAM3B family with sequence similarity 3, member B Oral Cavity - 3.08 0.007
29 EPPK1 epiplakin 1 Oral Cavity + 3.07 0.000
30 SPRR3 small proline-rich protein 3 Oral Cavity - 3.06 0.025
Search GEO for disease gene expression data for Tongue Squamous Cell Carcinoma.

Pathways for Tongue Squamous Cell Carcinoma

Pathways related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.87 TP53 MMP2 MIR21 CASP3
2 11.85 TP53 MIR222 MIR21 MIR133B CASP3
3 11.67 TP53 MMP2 CDH1 CASP3
4 11.36 TP53 MMP2 CDH1
5 9.88 UCA1 TP53 MEG3

GO Terms for Tongue Squamous Cell Carcinoma

Biological processes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA mediated inhibition of translation GO:0035278 9.13 MIR222 MIR21 MIR133B
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.8 MMP2 MIR222 MIR21

Sources for Tongue Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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