MCID: TNG009
MIFTS: 45

Tongue Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases, Smell/Taste diseases
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Aliases & Classifications for Tongue Squamous Cell Carcinoma

MalaCards integrated aliases for Tongue Squamous Cell Carcinoma:

Name: Tongue Squamous Cell Carcinoma 11 14 16
Squamous Cell Carcinoma of Tongue 71

Classifications:



External Ids:

Disease Ontology 11 DOID:0050865
NCIt 49 C4648
SNOMED-CT 68 276952000
UMLS 71 C0349566

Summaries for Tongue Squamous Cell Carcinoma

Disease Ontology: 11 A head and neck squamous cell carcinoma that is located in the tongue.

MalaCards based summary: Tongue Squamous Cell Carcinoma, also known as squamous cell carcinoma of tongue, is related to tongue carcinoma and oral squamous cell carcinoma. An important gene associated with Tongue Squamous Cell Carcinoma is MIR222 (MicroRNA 222), and among its related pathways/superpathways are miRNAs involved in DNA damage response and Cell differentiation - expanded index. The drugs Cisplatin and Fluorouracil have been mentioned in the context of this disorder. Affiliated tissues include tongue, lymph node and tonsil.

Related Diseases for Tongue Squamous Cell Carcinoma

Diseases related to Tongue Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 tongue carcinoma 32.2 MIR21 MIR139 MALAT1
2 oral squamous cell carcinoma 31.9 UCA1 MIR486-1 MIR21 MIR145 MIR139 MIR133B
3 squamous cell carcinoma, head and neck 31.7 MIR486-1 MIR222 MIR21 MIR145 MIR139 CYTOR
4 head and neck cancer 31.6 MIR486-1 MIR222 MIR21 MIR145 MIR139
5 oral cavity cancer 31.2 MIR486-1 MIR21 MIR145 MIR139
6 oropharynx cancer 31.1 MIR486-1 MIR21 MIR139
7 thyroid cancer, nonmedullary, 1 31.0 MIR222 MEG3 MALAT1 HOTTIP
8 thyroid carcinoma 31.0 UCA1 MALAT1 AFAP1-AS1
9 lung cancer susceptibility 3 30.9 MIR486-1 MIR21 MIR145 MIR139 MEG3 MALAT1
10 nasopharyngeal carcinoma 30.7 NKILA MIR486-1 MIR21 MIR145 MEG3 MALAT1
11 kidney cancer 30.7 MIR21 MIR145 MEG3 MALAT1
12 osteogenic sarcoma 30.7 UCA1 MEG3 MALAT1 HOTTIP
13 esophageal cancer 30.7 UCA1 MIR486-1 MIR222 MIR21 MIR145 MIR139
14 myocardial infarction 30.6 MIR486-1 MIR21 MIR145 MIR139 MIR133B BRINP3
15 gastric cancer 30.6 UCA1 MIR486-1 MIR222 MIR21 MIR145 MIR139
16 hepatocellular carcinoma 30.5 UCA1 PCBP2-OT1 NKILA MIR486-1 MIR222 MIR21
17 squamous cell carcinoma 11.5
18 lip and oral cavity cancer 10.9
19 down syndrome 10.6
20 esophagus adenocarcinoma 10.5 MIR21 MIR145 AFAP1-AS1
21 tongue disease 10.5 UCA1 MIR486-1 MIR21 MIR145 MIR139
22 biliary tract cancer 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
23 esophageal disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
24 bladder disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
25 gallbladder disease 10.5 MIR486-1 MIR222 MIR145 CYTOR
26 lymphatic system cancer 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
27 lymphatic system disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
28 colonic disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
29 central nervous system cancer 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
30 uterine anomalies 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
31 connective tissue cancer 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
32 laryngeal disease 10.5 MIR486-1 MIR21 MIR145 MIR139
33 esophagus squamous cell carcinoma 10.5 NKILA MEG3 MALAT1 HOTTIP CYTOR AFAP1-AS1
34 pancreas disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
35 spinal disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
36 ovary epithelial cancer 10.5 MIR222 MIR21 MIR145 MIR139
37 bone cancer 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
38 male reproductive organ cancer 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
39 glioma 10.5 UCA1 MIR222 MIR21 MEG3 MALAT1 HOTTIP
40 immune system disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
41 cholangiocarcinoma 10.5 UCA1 MIR21 MALAT1 AFAP1-AS1
42 male reproductive system disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
43 bile duct adenocarcinoma 10.5 MIR486-1 MIR21 MIR145 MIR139
44 reproductive system disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
45 high grade glioma 10.5 MIR21 MIR145 MEG3 MALAT1 HOTTIP CYTOR
46 urinary system disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
47 female reproductive system disease 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
48 bile duct disease 10.5 MIR486-1 MIR21 MIR145 MIR139
49 large intestine cancer 10.5 MIR486-1 MIR222 MIR21 MIR145 MIR139
50 biliary tract disease 10.5 MIR486-1 MIR21 MIR145 MIR139

Graphical network of the top 20 diseases related to Tongue Squamous Cell Carcinoma:



Diseases related to Tongue Squamous Cell Carcinoma

Symptoms & Phenotypes for Tongue Squamous Cell Carcinoma

Drugs & Therapeutics for Tongue Squamous Cell Carcinoma

Drugs for Tongue Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 2767 5702198 441203
2
Fluorouracil Approved Phase 2 51-21-8 3385
3
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
4
Nivolumab Approved Phase 2 946414-94-4
5
Ipilimumab Approved Phase 2 477202-00-9
6
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
7
Quercetin Experimental, Investigational Phase 2 117-39-5 10283929 5320834 5280343
8 Anesthetics Phase 2
9 Antimitotic Agents Phase 2
10 Tubulin Modulators Phase 2
11 Immunoglobulins Phase 2
12 Immune Checkpoint Inhibitors Phase 2
13 Antibodies, Monoclonal Phase 2
14 Antibodies Phase 2
15 Antineoplastic Agents, Immunological Phase 2
16 Anti-Bacterial Agents Phase 2
17 Antibiotics, Antitubercular Phase 2
18 Liposomal doxorubicin Phase 2
19 Antioxidants Phase 2
20 Protective Agents Phase 2
21
Ribavirin Approved 36791-04-5 37542
22
Luteolin Experimental Early Phase 1 491-70-3 5280445
23 Hemostatics
24 Antiviral Agents
25 Anti-Infective Agents
26 Antimetabolites

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy Versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer Recruiting NCT04333537 Phase 2, Phase 3 Imaging Agent
2 Role of Neo-adjuvant Chemotherapy in Organ Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue Unknown status NCT02985255 Phase 2 Docetaxel;Cisplatin;5FU
3 Phase 2 Study (With Safety Lead in) of the Safety, Tolerability and Efficacy of Anti-CTLA4 (Ipilimumab) and Anti-PD-1 (Nivolumab) in Combination With Radiation Therapy to 50-66 Gy in Low-Intermediate Volume, Local-Regionally Advanced HPV-Positive Oropharyngeal Squamous Cell Carcinoma (OPSCC) Recruiting NCT03799445 Phase 2
4 Therapeutic Efficacy of Quercetin Versus Its Encapsulated Nanoparticle on Tongue Squamous Cell Carcinoma Cell Line Not yet recruiting NCT05456022 Phase 2 Quercetin 3,3',4',5,6-Pentahydroxyflavone, 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one;Quercetin-encapsulated PLGA-PEG nanoparticles (Nano-QUT);Doxorubicin chemotherapeutic drug as a positive control
5 Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line: In Vitro Study Unknown status NCT03288298 Early Phase 1 luteolin;nano-luteolin
6 Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma (Randomize Noninferiority Clinical Trial) Unknown status NCT03440151
7 A Pilot Study to Assess the Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 ribavirin

Search NIH Clinical Center for Tongue Squamous Cell Carcinoma

Genetic Tests for Tongue Squamous Cell Carcinoma

Anatomical Context for Tongue Squamous Cell Carcinoma

Organs/tissues related to Tongue Squamous Cell Carcinoma:

FMA: Tongue
MalaCards : Tongue, Lymph Node, Tonsil, T Cells, Endothelial, Bone Marrow, Skeletal Muscle

Publications for Tongue Squamous Cell Carcinoma

Articles related to Tongue Squamous Cell Carcinoma:

(show top 50) (show all 1548)
# Title Authors PMID Year
1
MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines. 62 46
19487542 2009
2
MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. 46
19509158 2009
3
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. 46
18464261 2008
4
Genome-wide profiling of dysregulated piRNAs and their target genes implicated in oncogenicity of tongue squamous cell carcinoma. 62
36179965 2023
5
Constitutive activation of activator protein-1 as a cellular switch and its innovative role in the development of molecular targets for tongue squamous cell carcinoma treatment. 62
36244258 2022
6
Facial-submental island flap for reconstruction of hemitongue defects in young, middle-aged and elderly patients with early and middle stage oral tongue squamous cell carcinoma. 62
36471377 2022
7
Tumor-stroma ratio can predict lymph-node metastasis in cT1/2N0 oral tongue squamous cell carcinoma independent of tumor budding grade. 62
36197545 2022
8
miRNome-transcriptome analysis unveils the key regulatory pathways involved in the tumorigenesis of tongue squamous cell carcinoma. 62
36255066 2022
9
Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis. 62
35916453 2022
10
Involvement of AMPKα and MAPK-ERK/-JNK Signals in Docetaxel-Induced Human Tongue Squamous Cell Carcinoma Cell Apoptosis. 62
36430348 2022
11
Activated fibroblasts induce immune escape of TSCC through CCL25/AKT pathway. 62
36437627 2022
12
Development and validation of novel nomograms to predict survival of patients with tongue squamous cell carcinoma. 62
36405263 2022
13
Early-Stage Oral Tongue Squamous Cell Carcinoma and a Positive Sentinel Lymph Node Biopsy: Description of a Prognostic Correlation between Pre-Treatment Inflammatory Biomarkers, the Depth of Invasion and the Worst Pattern of Invasion. 62
36422107 2022
14
High-Frequency Intraoral Ultrasound for Preoperative Assessment of Depth of Invasion for Early Tongue Squamous Cell Carcinoma: Radiological-Pathological Correlations. 62
36429617 2022
15
Genome-wide DNA methylation profiling in tongue squamous cell carcinoma. 62
36398465 2022
16
The role of magnetic resonance imaging in assessing the extent of tongue squamous cell carcinoma: A prospective cohort study. 62
35257931 2022
17
Role of dysregulated miRNAs profiles as hallmarks in the pathogenesis and differential regulation of tongue squamous cell carcinoma. 62
36081305 2022
18
HSP90B1 overexpression is associated with poor prognosis in tongue squamous cell carcinoma. 62
35580785 2022
19
MAP3K11 facilitates autophagy activity and is correlated with malignancy of oral squamous cell carcinoma. 62
36103355 2022
20
Modified submandibular mandibulotomy approach without lip-splitting in tongue cancer. 62
36104264 2022
21
G-Quadruplex Aptamer-Ligand Characterization. 62
36296374 2022
22
Tertiary lymphoid structures associate with improved survival in early oral tongue cancer. 62
36309667 2022
23
Correction to: Elective Neck Dissection Versus Observation in cT1-T2 Oral Tongue Squamous Cell Carcinoma: A Meta-Analysis of 11,973 Patients. 62
36454204 2022
24
[High expression of CCBE1 in adjacent tissues of tongue squamous cell carcinoma is correlated with pericancerous lymphatic vessel proliferation and poor 5-year survival outcomes]. 62
36329590 2022
25
Hsa_circ_0081069 facilitates tongue squamous cell carcinoma progression by modulating MAP2K4 expression via miR-634. 62
36181561 2022
26
Elective Neck Dissection Versus Observation in cT1-T2 Oral Tongue Squamous Cell Carcinoma: A Meta-Analysis of 11,973 Patients. 62
36452646 2022
27
Qilan preparation inhibits proliferation and induces apoptosis by down-regulating microRNA-21 in human Tca8113 tongue squamous cell carcinoma cells. 62
36083475 2022
28
The incidence of occult level IV nodal metastasis in tongue squamous cell carcinoma: a 20 year review. 62
36196806 2022
29
TWIST1 regulates proliferation, migration, and invasion and is a prognostic marker for oral tongue squamous cell carcinoma. 62
36285599 2022
30
Prognosis of tongue squamous cell carcinoma associated with individual surgical margin and pathological features. 62
36316182 2022
31
[Retracted] Long non‑coding RNA PRNCR1 exerts oncogenic effects in tongue squamous cell carcinoma in vitro and in vivo by sponging microRNA‑944 and thereby increasing HOXB5 expression. 62
36004464 2022
32
[hsa_circ_0000231 affects the progression of tongue squamous cell carcinoma by activating Wnt/β-catenin signaling pathway]. 62
36319130 2022
33
Radiation modulates expression and related activities of c-Met protein in oral tongue squamous cell carcinoma cell lines. 62
36053327 2022
34
Corrigendum to <[Photodiagnosis and Photodynamic Therapy, Volume 32, December 2020, 102048]>. 62
36068732 2022
35
Protocol for a multicentre, prospective observational study of elective neck dissection for clinically node-negative oral tongue squamous cell carcinoma (END-TC study). 62
36100307 2022
36
Establishment and characterization of novel autologous pair cell lines from two Indian non‑habitual tongue carcinoma patients. 62
35796014 2022
37
Immunoexpression of REGγ and apoptosis-related proteins in oral tongue squamous cell carcinoma. 62
34955353 2022
38
Tongue squamous cell carcinoma resists hyperthermia treatment by promoting Id-1 expression mediated EMT. 62
35788271 2022
39
lncKRT16P6 promotes tongue squamous cell carcinoma progression by sponging miR‑3180 and regulating GATAD2A expression. 62
35904180 2022
40
Prognostic Value of Lymph Node Density Compared to Pre-operative Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio in Patients with Tongue Squamous Cell Carcinoma. 62
36274869 2022
41
MiR-873-5p modulates progression of tongue squamous cell carcinoma via targeting SEC11A. 62
33675129 2022
42
LINC00460 facilitated tongue squamous cell carcinoma progression via the miR-320b/IGF2BP3 axis. 62
33660359 2022
43
Adequacy of Disease Control by Supraomohyoid Neck Dissection in cT1/T2 Tongue Cancer. 62
36143322 2022
44
Use of the double-paddle anterolateral thigh flap for locally advanced tongue carcinoma requiring second site reconstruction. 62
36055115 2022
45
Recovery pattern analysis of swallowing function in patients undergoing total glossectomy and hemiglossectomy. 62
35752136 2022
46
Stabilization of a DNA aptamer by ligand binding. 62
35550917 2022
47
Fusobacterium is enriched in oral cancer and promotes induction of programmed death-ligand 1 (PD-L1). 62
35834946 2022
48
Treatment outcomes and prognostic factors in oral tongue cancer: a 20-year retrospective study at the National Cancer Center, South Korea. 62
36043249 2022
49
Depth of Invasion as an Independent Predictor of Survival in Patients of Stage III Squamous Cell Carcinoma of the Oral Tongue. 62
34918353 2022
50
Utility of a palatal speech appliance combined with the five-point eight-line segment technique in total tongue reconstruction. 62
35086759 2022

Variations for Tongue Squamous Cell Carcinoma

Expression for Tongue Squamous Cell Carcinoma

LifeMap Discovery
Genes differentially expressed in tissues of Tongue Squamous Cell Carcinoma patients vs. healthy controls: 35 (show all 30)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 MMP1 matrix metallopeptidase 1 Oral Cavity + 6.95 0.000
2 TMPRSS11B transmembrane serine protease 11B Oral Cavity - 5.73 0.000
3 MAL mal, T cell differentiation protein Oral Cavity - 5.07 0.000
4 CRNN cornulin Oral Cavity - 4.97 0.000
5 KRT13 keratin 13 Oral Cavity - 4.67 0.001
6 MYH2 myosin heavy chain 2 Oral Cavity - 4.12 0.005
7 PTHLH parathyroid hormone like hormone Oral Cavity + 4.09 0.000
8 KRT17 keratin 17 Oral Cavity + 3.76 0.000
9 CXCL12 C-X-C motif chemokine ligand 12 Oral Cavity - 3.73 0.000
10 LAMC2 laminin subunit gamma 2 Oral Cavity + 3.68 0.000
11 CLCA4 chloride channel accessory 4 Oral Cavity - 3.65 0.000
12 CXCL1 C-X-C motif chemokine ligand 1 Oral Cavity + 3.44 0.000
13 LDB3 LIM domain binding 3 Oral Cavity - 3.41 0.003
14 MMP3 matrix metallopeptidase 3 Oral Cavity + 3.39 0.000
15 CLU clusterin Oral Cavity - 3.38 0.000
16 CFAP251 cilia and flagella associated protein 251 Oral Cavity + 3.37 0.000
17 GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 Oral Cavity - 3.36 0.000
18 PRR9 proline rich 9 Oral Cavity + 3.34 0.004
19 CXCL8 C-X-C motif chemokine ligand 8 Oral Cavity + 3.33 0.000
20 CRISP3 cysteine rich secretory protein 3 Oral Cavity - 3.23 0.010
21 CYP4B1 cytochrome P450 family 4 subfamily B member 1 Oral Cavity - 3.21 0.000
22 SPINK5 serine peptidase inhibitor Kazal type 5 Oral Cavity - 3.20 0.002
23 S100A7A S100 calcium binding protein A7A Oral Cavity + 3.15 0.001
24 IFI6 interferon alpha inducible protein 6 Oral Cavity + 3.13 0.000
25 INHBA inhibin subunit beta A Oral Cavity + 3.13 0.001
26 KRT4 keratin 4 Oral Cavity - 3.11 0.000
27 ABCA8 ATP binding cassette subfamily A member 8 Oral Cavity - 3.10 0.000
28 FAM3B FAM3 metabolism regulating signaling molecule B Oral Cavity - 3.08 0.007
29 EPPK1 epiplakin 1 Oral Cavity + 3.07 0.000
30 SPRR3 small proline rich protein 3 Oral Cavity - 3.06 0.025
Search GEO for disease gene expression data for Tongue Squamous Cell Carcinoma.

Pathways for Tongue Squamous Cell Carcinoma

Pathways related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 MIR222 MIR21 MIR145
2
Show member pathways
10.82 MIR486-1 MIR222 MIR145 MIR133B
3 10.41 UCA1 MIR21

GO Terms for Tongue Squamous Cell Carcinoma

Cellular components related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RISC complex GO:0016442 9.47 MIR486-1 MIR222 MIR21 MIR145 MIR139 MIR133B

Biological processes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA-mediated gene silencing GO:0035195 10 MIR486-1 MIR222 MIR21 MIR145 MIR139 MIR133B
2 negative regulation of interleukin-21 production GO:0032705 9.16 MIR222 MIR21
3 positive regulation of cellular response to hypoxia GO:1900039 8.96 MIR21 MIR145
4 miRNA-mediated gene silencing by inhibition of translation GO:0035278 8.92 MIR222 MIR21 MIR145 MIR133B

Molecular functions related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.5 MIR486-1 MIR21 MIR145 MIR139 MIR133B DND1
2 mRNA base-pairing translational repressor activity GO:1903231 9.1 MIR486-1 MIR222 MIR21 MIR145 MIR139 MIR133B

Sources for Tongue Squamous Cell Carcinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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