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MCID: TNG009
MIFTS: 49

Tongue Squamous Cell Carcinoma

Categories: Cancer diseases, Oral diseases, Gastrointestinal diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Tongue Squamous Cell Carcinoma

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MalaCards integrated aliases for Tongue Squamous Cell Carcinoma:

Name: Tongue Squamous Cell Carcinoma 38 12 15
Squamous Cell Carcinoma of Tongue 73
Carcinoma, Squamous Cell 44

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Oral diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050865
MeSH 44 D002294
NCIt 50 C2929
UMLS 73 C0349566
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Summaries for Tongue Squamous Cell Carcinoma

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Disease Ontology : 12 A head and neck squamous cell carcinoma that is located in the tongue.

MalaCards based summary : Tongue Squamous Cell Carcinoma, also known as squamous cell carcinoma of tongue, is related to squamous cell carcinoma and tongue cancer. An important gene associated with Tongue Squamous Cell Carcinoma is MIR21 (MicroRNA 21
MiR-21 is overexpressed in TSCC relative to adjacent normal tissues. The level of miR-21 is reversely correlated with TPM1 and PTEN expression and apoptosis of cancer cells. Multivariate analysis showed that miR-21 expression is an independent prognostic factor indicating poor survival. Inhibiting miR-21 with ASO in TSCC cell lines reduces survival and anchorage-independent growth, and induces apoptosis in TSCC cell lines. Simultaneous silencing of TPM1 with siRNA only partially recapitulates the effect of miR-21 ASO. Furthermore, repeated injection of miR-21 ASO suppresses tumor formation in nude mice by reducing cell proliferation and inducing apoptosis. CONCLUSIONS: miR-21 is an independent prognostic indicator for TSCC, and may play a role in TSCC development by inhibiting cancer cell apoptosis partly via TPM1 silencing.), and among its related pathways/superpathways are Development EGFR signaling pathway and Proteoglycans in cancer. The drugs Cetuximab and Cisplatin have been mentioned in the context of this disorder. Affiliated tissues include the tongue, tongue and lymph node.

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Related Diseases for Tongue Squamous Cell Carcinoma

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Diseases related to Tongue Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 31.4 CDH1 LINC01503 MALAT1 TP53 UCA1
2 tongue cancer 30.4 CDH1 MALAT1 MMP2 TP53
3 nasopharyngeal carcinoma 27.7 AFAP1-AS1 CASP3 CDH1 MALAT1 MEG3 NKILA
4 squamous cell carcinoma of the oral tongue 11.2
5 short-rib thoracic dysplasia 4 with or without polydactyly 10.9 CASP3 TP53
6 cerebral convexity meningioma 10.9 CDH1 TP53
7 vulvar intraepithelial neoplasia 10.9 CDH1 MMP2 TP53
8 polymyositis 10.9 MIR21 MIR222
9 ovarian cancer 1 10.8 CDH1 MMP2 TP53
10 malignant ovarian surface epithelial-stromal neoplasm 10.8 CDH1 MMP2 TP53
11 ovary epithelial cancer 10.8 CDH1 MMP2 TP53
12 pharynx cancer 10.8 CASP3 CDH1 TP53
13 anaplastic thyroid cancer 10.8 CASP3 CDH1 TP53
14 internal hemorrhoid 10.8 CASP3 MMP2
15 male reproductive organ cancer 10.8 CASP3 CDH1 TP53
16 female reproductive organ cancer 10.7 CASP3 CDH1 MMP2 TP53
17 cell type cancer 10.7 CASP3 CDH1 MMP2 TP53
18 larynx cancer 10.7 MIR21 MMP2 TP53
19 oral cancer 10.7 CASP3 CDH1 MIR21 MMP2 TP53
20 skin melanoma 10.6 CASP3 MMP2 TP53
21 dermatomyositis 10.5 MIR21 MIR222
22 squamous cell carcinoma, head and neck 10.4 CDH1 CYTOR MIR21 MMP2 TP53
23 vulva squamous cell carcinoma 10.3 MALAT1 MEG3 TP53
24 microcystic meningioma 10.2 CDH1 MMP2
25 hypoxia 10.2
26 respiratory system cancer 10.2 CASP3 CDH1 MALAT1 MMP2 TP53
27 prostate disease 10.2 MALAT1 MEG3
28 kidney cancer 10.2 MALAT1 MEG3 MIR21
29 gastrointestinal system cancer 10.2 CASP3 CDH1 MALAT1 MMP2 TP53
30 endotheliitis 10.2
31 klatskin's tumor 10.2 MALAT1 MMP2
32 endometrial cancer 10.1 CASP3 CDH1 MEG3 MMP2 TP53 UCA1
33 small cell cancer of the lung 10.1 HOTTIP MALAT1 MIR21 TP53
34 esophagus adenocarcinoma 10.1 AFAP1-AS1 MIR21 TP53
35 mantle cell lymphoma 10.1 CASP3 MALAT1 TP53
36 cervicitis 10.1
37 bladder urothelial carcinoma 10.0 CASP3 CDH1 MALAT1 MEG3 TP53
38 myeloma, multiple 9.9 CASP3 MALAT1 MEG3 TP53 UCA1
39 esophagus squamous cell carcinoma 9.9 AFAP1-AS1 MEG3
40 renal cell carcinoma, nonpapillary 9.9 CDH1 CYTOR MALAT1 MMP2 UCA1
41 malignant glioma 9.9 CYTOR HOTTIP MALAT1 MEG3
42 osteogenic sarcoma 9.8 HOTTIP MALAT1 MEG3 TP53 UCA1
43 aging 9.8
44 nasopharyngitis 9.8
45 papilloma 9.8
46 gingivitis 9.8
47 pulmonary embolism 9.8
48 thyroid cancer, nonmedullary, 1 9.8 HOTTIP MALAT1 MEG3 MIR21 MIR222
49 clear cell renal cell carcinoma 9.8 CDH1 CYTOR MALAT1 MEG3 MIR21
50 cervical cancer 9.7 CASP3 MALAT1 MEG3 MIR21 MMP2 TP53

Graphical network of the top 20 diseases related to Tongue Squamous Cell Carcinoma:



Diseases related to Tongue Squamous Cell Carcinoma
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Symptoms & Phenotypes for Tongue Squamous Cell Carcinoma

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Drugs & Therapeutics for Tongue Squamous Cell Carcinoma

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Drugs for Tongue Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
2
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
3
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
4
Fluorouracil Approved Phase 2 51-21-8 3385
5 Anesthetics Phase 2
6 Antimitotic Agents Phase 2
7
Ribavirin Approved Not Applicable 36791-04-5 37542
8 Anti-Infective Agents Not Applicable
9 Antimetabolites Not Applicable
10 Antiviral Agents Not Applicable
11
Luteolin Nutraceutical Early Phase 1 491-70-3 5280445

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment in Locally Advanced Tongue Cancer ; A NEW PARADIGM OF TREATMENT Unknown status NCT01760811 Phase 1, Phase 2 Erbitux,merck serono
2 Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue Recruiting NCT02985255 Phase 2 Docetaxel;Cisplatin;5FU
3 Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva Unknown status NCT00426062
4 Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma Recruiting NCT03440151 Not Applicable
5 Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 Not Applicable ribavirin
6 Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line Not yet recruiting NCT03288298 Early Phase 1 luteolin;nano-luteolin

Search NIH Clinical Center for Tongue Squamous Cell Carcinoma

Cochrane evidence based reviews: carcinoma, squamous cell

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Genetic Tests for Tongue Squamous Cell Carcinoma

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Anatomical Context for Tongue Squamous Cell Carcinoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Tongue Squamous Cell Carcinoma:

19
The Tongue

MalaCards organs/tissues related to Tongue Squamous Cell Carcinoma:

41
Tongue, Lymph Node, T Cells, Tonsil, Endothelial, Skeletal Muscle, Neutrophil
Sources

Publications for Tongue Squamous Cell Carcinoma

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Articles related to Tongue Squamous Cell Carcinoma:

(show top 50) (show all 325)
# Title Authors Year
1
Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma. ( 29751146 )
2018
2
FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment. ( 29393475 )
2018
3
Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis". ( 29449674 )
2018
4
Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'. ( 29449675 )
2018
5
A rapidly growing human papillomavirus-positive oral tongue squamous cell carcinoma in a 21-year old female: A case report. ( 29849799 )
2018
6
miR-409-3p suppresses the proliferation, invasion and migration of tongue squamous cell carcinoma via targeting <i>RDX</i>. ( 29928443 )
2018
7
Extracellular interleukin-17F has a protective effect in oral tongue squamous cell carcinoma. ( 29761594 )
2018
8
Obovatol inhibits the growth and aggressiveness of tongue squamous cell carcinoma through regulation of the EGFa89mediated JAKa89STAT signaling pathway. ( 29845251 )
2018
9
LINC00511 interacts with miR-765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2. ( 29315846 )
2018
10
CBX3/HP1I^ is upregulated in tongue squamous cell carcinoma and is associated with an unfavorable prognosis. ( 29731822 )
2018
11
CD63 inhibits the cell migration and invasion ability of tongue squamous cell carcinoma. ( 29844819 )
2018
12
C-reactive protein is associated with the development of tongue squamous cell carcinoma. ( 29385406 )
2018
13
Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia. ( 29682563 )
2018
14
Morphological features of tongue squamous cell carcinoma diagnosed in Dolj County population between 2012-2014. ( 29940622 )
2018
15
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features. ( 29747237 )
2018
16
MicroRNA-155, -185 and -193b as biomarkers in human papillomavirus positive and negative tonsillar and base of tongue squamous cell carcinoma. ( 29909906 )
2018
17
Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma. ( 29681158 )
2018
18
CRBP-1 over-expression is associated with poor prognosis in tongue squamous cell carcinoma. ( 29720147 )
2018
19
Long noncoding RNA GIHCG enhanced tongue squamous cell carcinoma progression through regulating miR-429. ( 29953645 )
2018
20
Epithelial mesenchymal transition induced by the CXCL9/CXCR3 axis through AKT activation promotes invasion and metastasis in tongue squamous cell carcinoma. ( 29286143 )
2018
21
Constituents of Propolis: Chrysin, Caffeic Acid, <i>p</i>-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27). ( 29681859 )
2018
22
IRX5 promotes NF-I_B signalling to increase proliferation, migration and invasion via OPN in tongue squamous cell carcinoma. ( 29761910 )
2018
23
Global Quantitative Proteomics reveal Deregulation of Cytoskeletal and Apoptotic Signalling Proteins in Oral Tongue Squamous Cell Carcinoma. ( 29371635 )
2018
24
Sox2 promotes tumor aggressiveness and epitheliala89mesenchymal transition in tongue squamous cell carcinoma. ( 29956740 )
2018
25
Tongue Squamous Cell Carcinoma in a European Lynx (Lynx Lynx): Papillomavirus Infection and Histologic Analysis. ( 29301274 )
2018
26
Adipose-derived stem cell conditioned medium attenuates cisplatin-triggered apoptosis in tongue squamous cell carcinoma. ( 29207154 )
2018
27
Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/I^-catenin signaling pathway. ( 29310682 )
2018
28
FoxM1 promotes epithelial-mesenchymal transition, invasion, and migration of tongue squamous cell carcinoma cells through a c-Met/AKT-dependent positive feedback loop. ( 29360662 )
2018
29
Tumor budding as a novel predictor of occult metastasis in cT2N0 tongue squamous cell carcinoma. ( 29307623 )
2018
30
Digital metastasis of tongue squamous cell carcinoma. ( 29892666 )
2018
31
A Prognostic Nomogram Incorporating Depth of Tumor Invasion to Predict Long-term Overall Survival for Tongue Squamous Cell Carcinoma With R0 Resection. ( 29937929 )
2018
32
Prognostic impact of perineural invasion in early stage oral tongue squamous cell carcinoma: Results from a prospective randomized trial. ( 29937161 )
2018
33
MicroRNA-196a-5p is a potential prognostic marker of delayed lymph node metastasis in early-stage tongue squamous cell carcinoma. ( 29434944 )
2018
34
CBX3 promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma. ( 29462646 )
2018
35
Unusual Multinucleated Giant Cell Reaction in a Tongue Squamous Cell Carcinoma: Histopathological and Immunohistochemical Features. ( 29427031 )
2018
36
Vimentin is a potential prognostic factor for tongue squamous cell carcinoma among five epithelial-mesenchymal transition-related proteins. ( 28570699 )
2017
37
Mesenchymal stem cell-derived CCN2 promotes the proliferation, migration and invasion of human tongue squamous cell carcinoma cells. ( 28208216 )
2017
38
Trichostatin A increases radiosensitization of tongue squamous cell carcinoma via miRa89375. ( 27878285 )
2017
39
Cryptotanshinone sensitizes antitumor effect of paclitaxel on tongue squamous cell carcinoma growth by inhibiting the JAK/STAT3 signaling pathway. ( 28946186 )
2017
40
The interplay of matrix metalloproteinase-8, transforming growth factor-I^1 and vascular endothelial growth factor-C cooperatively contributes to the aggressiveness of oral tongue squamous cell carcinoma. ( 28772283 )
2017
41
Diagnostic value of sentinel lymph node biopsy for cT1/T2N0 tongue squamous cell carcinoma: a meta-analysis. ( 28900723 )
2017
42
An inA vitro study of the long non-coding RNA TUG1 in tongue squamous cell carcinoma. ( 28597931 )
2017
43
Isobavachalcone inhibits the proliferation and invasion of tongue squamous cell carcinoma cells. ( 28928824 )
2017
44
Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma. ( 28700659 )
2017
45
Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma. ( 28747140 )
2017
46
Circadian Clock Gene Bmal1 Inhibits Tumorigenesis and Increases Paclitaxel Sensitivity in Tongue Squamous Cell Carcinoma. ( 27821487 )
2017
47
Inhibition of mTOR/eIF4E by anti-viral drug ribavirin effectively enhances the effects of paclitaxel in oral tongue squamous cell carcinoma. ( 27932243 )
2017
48
Transoral robotic surgery for the base of tongue squamous cell carcinoma: a preliminary comparison between da Vinci Xi and Si. ( 28905287 )
2017
49
Radiosensitization of oral tongue squamous cell carcinoma by nanosecond pulsed electric fields (nsPEFs). ( 27676191 )
2017
50
PTK7 is a molecular marker for metastasis, TNM stage, and prognosis in oral tongue squamous cell carcinoma. ( 28547980 )
2017
Sources

Variations for Tongue Squamous Cell Carcinoma

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Cosmic variations for Tongue Squamous Cell Carcinoma:

9
(show top 50) (show all 202)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6957917 TSC2 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1120A>T p.T374S 16:2061871-2061871 13
2 COSM43708 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 17:7675190-7675190 13
3 COSM10660 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 13
4 COSM43833 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>C p.H193P 17:7674953-7674953 13
5 COSM10771 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.749C>T p.P250L 17:7674214-7674214 13
6 COSM10663 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 13
7 COSM10656 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 13
8 COSM10724 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 13
9 COSM43680 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 13
10 COSM10867 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 13
11 COSM10648 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 13
12 COSM11089 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.584T>C p.I195T 17:7674947-7674947 13
13 COSM43903 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.470T>G p.V157G 17:7675142-7675142 13
14 COSM10726 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 13
15 COSM44393 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.821T>C p.V274A 17:7673799-7673799 13
16 COSM43814 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.587G>C p.R196P 17:7674944-7674944 13
17 COSM10704 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 13
18 COSM10662 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 13
19 COSM43963 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 13
20 COSM43747 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.872A>G p.K291R 17:7673748-7673748 13
21 COSM43841 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.560-1G>T p.? 17:7674972-7674972 13
22 COSM6932 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 13
23 COSM44424 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.590T>A p.V197E 17:7674941-7674941 13
24 COSM10654 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 13
25 COSM44785 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.702C>G p.Y234* 17:7674261-7674261 13
26 COSM11450 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.644G>T p.S215I 17:7674887-7674887 13
27 COSM44567 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.647T>C p.V216A 17:7674884-7674884 13
28 COSM11196 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.734G>T p.G245V 17:7674229-7674229 13
29 COSM44411 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.608T>A p.V203E 17:7674923-7674923 13
30 COSM10834 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.711G>A p.M237I 17:7674252-7674252 13
31 COSM43621 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.809T>G p.F270C 17:7673811-7673811 13
32 COSM44351 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.572C>T p.P191L 17:7674959-7674959 13
33 COSM11073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 13
34 COSM44262 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.808T>C p.F270L 17:7673812-7673812 13
35 COSM45132 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.783-2A>G p.? 17:7673839-7673839 13
36 COSM43695 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.748C>T p.P250S 17:7674215-7674215 13
37 COSM44523 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.863A>G p.N288S 17:7673757-7673757 13
38 COSM45135 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.673-1G>T p.? 17:7674291-7674291 13
39 COSM10859 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.814G>T p.V272L 17:7673806-7673806 13
40 COSM11066 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>T p.H193L 17:7674953-7674953 13
41 COSM10992 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>G p.R282G 17:7673776-7673776 13
42 COSM10739 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.481G>A p.A161T 17:7675131-7675131 13
43 COSM11147 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.370T>C p.C124R 17:7675999-7675999 13
44 COSM10790 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.455C>T p.P152L 17:7675157-7675157 13
45 COSM44073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.374C>A p.T125K 17:7675995-7675995 13
46 COSM10939 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.832C>T p.P278S 17:7673788-7673788 13
47 COSM10645 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 13
48 COSM10687 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>A p.C176Y 17:7675085-7675085 13
49 COSM10905 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 13
50 COSM10727 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.438G>A p.W146* 17:7675174-7675174 13
Sources

Expression for Tongue Squamous Cell Carcinoma

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LifeMap Discovery
Genes differentially expressed in tissues of Tongue Squamous Cell Carcinoma patients vs. healthy controls: 35 (show all 30)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 MMP1 matrix metallopeptidase 1 Oral Cavity + 6.95 0.000
2 TMPRSS11B transmembrane protease, serine 11B Oral Cavity - 5.73 0.000
3 MAL mal, T-cell differentiation protein Oral Cavity - 5.07 0.000
4 CRNN cornulin Oral Cavity - 4.97 0.000
5 KRT13 keratin 13, type I Oral Cavity - 4.67 0.001
6 MYH2 myosin, heavy chain 2, skeletal muscle, adult Oral Cavity - 4.12 0.005
7 PTHLH parathyroid hormone-like hormone Oral Cavity + 4.09 0.000
8 KRT17 keratin 17, type I Oral Cavity + 3.76 0.000
9 CXCL12 chemokine (C-X-C motif) ligand 12 Oral Cavity - 3.73 0.000
10 LAMC2 laminin, gamma 2 Oral Cavity + 3.68 0.000
11 CLCA4 chloride channel accessory 4 Oral Cavity - 3.65 0.000
12 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Oral Cavity + 3.44 0.000
13 LDB3 LIM domain binding 3 Oral Cavity - 3.41 0.003
14 MMP3 matrix metallopeptidase 3 Oral Cavity + 3.39 0.000
15 CLU clusterin Oral Cavity - 3.38 0.000
16 WDR66 WD repeat domain 66 Oral Cavity + 3.37 0.000
17 GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 Oral Cavity - 3.36 0.000
18 PRR9 proline rich 9 Oral Cavity + 3.34 0.004
19 CXCL8 chemokine (C-X-C motif) ligand 8 Oral Cavity + 3.33 0.000
20 CRISP3 cysteine-rich secretory protein 3 Oral Cavity - 3.23 0.010
21 CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 Oral Cavity - 3.21 0.000
22 SPINK5 serine peptidase inhibitor, Kazal type 5 Oral Cavity - 3.20 0.002
23 S100A7A S100 calcium binding protein A7A Oral Cavity + 3.15 0.001
24 IFI6 interferon, alpha-inducible protein 6 Oral Cavity + 3.13 0.000
25 INHBA inhibin, beta A Oral Cavity + 3.13 0.001
26 KRT4 keratin 4, type II Oral Cavity - 3.11 0.000
27 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 Oral Cavity - 3.10 0.000
28 FAM3B family with sequence similarity 3, member B Oral Cavity - 3.08 0.007
29 EPPK1 epiplakin 1 Oral Cavity + 3.07 0.000
30 SPRR3 small proline-rich protein 3 Oral Cavity - 3.06 0.025
Search GEO for disease gene expression data for Tongue Squamous Cell Carcinoma.
Sources

Pathways for Tongue Squamous Cell Carcinoma

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Pathways related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development EGFR signaling pathway 22
Show member pathways
 12.15 CASP3 CDH1 MMP2 TP53
2
Proteoglycans in cancer 37
11.86 CASP3 MIR21 MMP2 TP53
3
MicroRNAs in cancer 37
11.83 CASP3 MIR133B MIR21 MIR222 TP53
4
Colorectal Cancer Metastasis 64
11.67 CASP3 CDH1 MMP2 TP53
5
Bladder cancer 37 1
11.36 CDH1 MMP2 TP53
6
LncRNA-mediated mechanisms of therapeutic resistance 1
9.88 MEG3 TP53 UCA1
Sources

GO Terms for Tongue Squamous Cell Carcinoma

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Biological processes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to X-ray GO:0010165 9.16 CASP3 TP53
2 miRNA mediated inhibition of translation GO:0035278 9.13 MIR133B MIR21 MIR222
3 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.8 MIR21 MIR222 MMP2
Sources

Sources for Tongue Squamous Cell Carcinoma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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