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MCID: TNG009
MIFTS: 47

Tongue Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Tongue Squamous Cell Carcinoma

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MalaCards integrated aliases for Tongue Squamous Cell Carcinoma:

Name: Tongue Squamous Cell Carcinoma 38 12 15
Squamous Cell Carcinoma of Tongue 73

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Oral diseases Gastrointestinal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:0050865
NCIt 50 C4648
UMLS 73 C0349566
Sources

Summaries for Tongue Squamous Cell Carcinoma

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Disease Ontology : 12 A head and neck squamous cell carcinoma that is located in the tongue.

MalaCards based summary : Tongue Squamous Cell Carcinoma, also known as squamous cell carcinoma of tongue, is related to squamous cell carcinoma and tongue cancer. An important gene associated with Tongue Squamous Cell Carcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways are Development EGFR signaling pathway and Proteoglycans in cancer. The drugs Cetuximab and Docetaxel have been mentioned in the context of this disorder. Affiliated tissues include the tongue, tongue and lymph node.

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Related Diseases for Tongue Squamous Cell Carcinoma

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Diseases related to Tongue Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 31.9 CDH1 LINC01503 MALAT1 MMP2 TP53 UCA1
2 tongue cancer 30.2 CASP3 CDH1 MALAT1 MMP2 TP53
3 thyroid cancer, nonmedullary, 1 29.9 HOTTIP MALAT1 MEG3 MIR222
4 cervical cancer 29.7 CASP3 CDH1 MALAT1 MEG3 MIR21 MMP2
5 thyroid cancer 29.6 AFAP1-AS1 CASP3 CDH1 MALAT1 TP53 UCA1
6 nasopharyngeal carcinoma 29.3 AFAP1-AS1 CASP3 CDH1 MALAT1 MEG3 MMP2
7 squamous cell carcinoma of the oral tongue 11.8
8 hypoxia 10.4
9 short-rib thoracic dysplasia 4 with or without polydactyly 10.3 CASP3 TP53
10 male reproductive system disease 10.3 CASP3 CDH1 TP53
11 supratentorial cancer 10.3 CASP3 MMP2 TP53
12 cerebral convexity meningioma 10.3 CDH1 TP53
13 cerebrum cancer 10.3 CASP3 MMP2 TP53
14 nasopharyngeal disease 10.3 CASP3 CDH1 TP53
15 laryngeal disease 10.3 CDH1 MMP2 TP53
16 skin melanoma 10.3 CASP3 MMP2 TP53
17 ovarian cancer 1 10.3 CDH1 MMP2 TP53
18 malignant ovarian surface epithelial-stromal neoplasm 10.3 CDH1 MMP2 TP53
19 ovary epithelial cancer 10.3 CDH1 MMP2 TP53
20 pharynx cancer 10.3 CASP3 CDH1 TP53
21 cervix disease 10.3 CASP3 CDH1 TP53
22 uterine anomalies 10.3 CASP3 CDH1 TP53
23 anaplastic thyroid cancer 10.3 CASP3 CDH1 TP53
24 male reproductive organ cancer 10.2 CASP3 CDH1 TP53
25 polymyositis 10.2 MIR21 MIR222
26 colonic disease 10.2 CASP3 CDH1 TP53
27 female reproductive system disease 10.2 CASP3 CDH1 MMP2 TP53
28 reproductive system disease 10.2 CASP3 CDH1 MMP2 TP53
29 bladder disease 10.2 CDH1 TP53 UCA1
30 stomach disease 10.2 CASP3 CDH1 TP53
31 endocrine gland cancer 10.2 CASP3 CDH1 MMP2 TP53
32 gastrointestinal system disease 10.2 CASP3 CDH1 MMP2 TP53
33 intestinal disease 10.2 CASP3 CDH1 TP53
34 tongue disease 10.2 CDH1 LINC01527 MMP2 TP53
35 oral cancer 10.2 CASP3 CDH1 MIR21 MMP2 TP53
36 respiratory system disease 10.2 CASP3 CDH1 TP53
37 larynx cancer 10.2 MIR21 MMP2 TP53
38 large intestine cancer 10.1 CASP3 CDH1 MMP2 TP53
39 esophagus adenocarcinoma 10.1 AFAP1-AS1 MIR21 TP53
40 vulva squamous cell carcinoma 10.1 MALAT1 MEG3 TP53
41 squamous cell carcinoma, head and neck 10.1 CASP3 CDH1 CYTOR MIR21 MMP2 TP53
42 gastric adenocarcinoma 10.1 CASP3 CDH1 MMP2 TP53
43 laryngeal squamous cell carcinoma 10.1 CDH1 MALAT1 MIR21 TP53
44 pancreas adenocarcinoma 10.1 CASP3 CDH1 TP53
45 ovarian epithelial cancer 10.1 MALAT1 MEG3
46 esophagus squamous cell carcinoma 10.1 AFAP1-AS1 MEG3
47 respiratory system cancer 10.1 CASP3 CDH1 MALAT1 MMP2 TP53
48 endometrial cancer 10.1 CASP3 CDH1 MEG3 MMP2 TP53 UCA1
49 gastrointestinal system cancer 10.1 CASP3 CDH1 MALAT1 MMP2 TP53
50 small cell cancer of the lung 10.1 HOTTIP MALAT1 MIR21 TP53

Graphical network of the top 20 diseases related to Tongue Squamous Cell Carcinoma:



Diseases related to Tongue Squamous Cell Carcinoma
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Symptoms & Phenotypes for Tongue Squamous Cell Carcinoma

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Drugs & Therapeutics for Tongue Squamous Cell Carcinoma

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Drugs for Tongue Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
2
Docetaxel Approved, Investigational Phase 2 114977-28-5 148124
3
Cisplatin Approved Phase 2 15663-27-1 2767 441203 84093
4
Fluorouracil Approved Phase 2 51-21-8 3385
5 Antimitotic Agents Phase 2
6 Anesthetics Phase 2,Not Applicable
7
Ribavirin Approved Not Applicable 36791-04-5 37542
8 Hemostatics Not Applicable
9 Antimetabolites Not Applicable
10 Anti-Infective Agents Not Applicable
11 Antiviral Agents Not Applicable
12
Luteolin Early Phase 1 491-70-3 5280445

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment in Locally Advanced Tongue Cancer ; A NEW PARADIGM OF TREATMENT Unknown status NCT01760811 Phase 1, Phase 2 Erbitux,merck serono
2 Role of Neo-adjuvant Chemotherapy in Tongue Preservation in Locally Advanced Squamous Cell Carcinoma of Oral Tongue Unknown status NCT02985255 Phase 2 Docetaxel;Cisplatin;5FU
3 Ipilimumab, Nivolumab, and Radiation Therapy in Treating Patients With HPV Positive Advanced Oropharyngeal Squamous Cell Carcinoma Not yet recruiting NCT03799445 Phase 2
4 Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva Unknown status NCT00426062
5 Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma Recruiting NCT03440151 Not Applicable
6 Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 Not Applicable ribavirin
7 Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line Not yet recruiting NCT03288298 Early Phase 1 luteolin;nano-luteolin

Search NIH Clinical Center for Tongue Squamous Cell Carcinoma

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Genetic Tests for Tongue Squamous Cell Carcinoma

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Anatomical Context for Tongue Squamous Cell Carcinoma

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The Foundational Model of Anatomy Ontology organs/tissues related to Tongue Squamous Cell Carcinoma:

19
The Tongue

MalaCards organs/tissues related to Tongue Squamous Cell Carcinoma:

41
Tongue, Lymph Node, T Cells, Endothelial, Tonsil, Thyroid, Skeletal Muscle
Sources

Publications for Tongue Squamous Cell Carcinoma

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Articles related to Tongue Squamous Cell Carcinoma:

(show top 50) (show all 506)
# Title Authors Year
1
High expression of TMEM40 contributes to progressive features of tongue squamous cell carcinoma. ( 30320346 )
2019
2
CRNDE promotes cell tongue squamous cell carcinoma cell growth and invasion through suppressing miR-384. ( 30242873 )
2019
3
Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma. ( 29751146 )
2018
4
FNDC3B promotes epithelial-mesenchymal transition in tongue squamous cell carcinoma cells in a hypoxic microenvironment. ( 29393475 )
2018
5
Reply to 'Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis". ( 29449674 )
2018
6
Comment on 'Prognostic biomarkers for oral tongue squamous cell carcinoma: a systematic review and meta-analysis'. ( 29449675 )
2018
7
A rapidly growing human papillomavirus-positive oral tongue squamous cell carcinoma in a 21-year old female: A case report. ( 29849799 )
2018
8
miR-409-3p suppresses the proliferation, invasion and migration of tongue squamous cell carcinoma via targeting <i>RDX</i>. ( 29928443 )
2018
9
Extracellular interleukin-17F has a protective effect in oral tongue squamous cell carcinoma. ( 29761594 )
2018
10
Obovatol inhibits the growth and aggressiveness of tongue squamous cell carcinoma through regulation of the EGFa89mediated JAKa89STAT signaling pathway. ( 29845251 )
2018
11
LINC00511 interacts with miR-765 and modulates tongue squamous cell carcinoma progression by targeting LAMC2. ( 29315846 )
2018
12
CBX3/HP1I^ is upregulated in tongue squamous cell carcinoma and is associated with an unfavorable prognosis. ( 29731822 )
2018
13
CD63 inhibits the cell migration and invasion ability of tongue squamous cell carcinoma. ( 29844819 )
2018
14
C-reactive protein is associated with the development of tongue squamous cell carcinoma. ( 29385406 )
2018
15
Deregulation of Hexokinase II Is Associated with Glycolysis, Autophagy, and the Epithelial-Mesenchymal Transition in Tongue Squamous Cell Carcinoma under Hypoxia. ( 29682563 )
2018
16
Morphological features of tongue squamous cell carcinoma diagnosed in Dolj County population between 2012-2014. ( 29940622 )
2018
17
Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features. ( 29747237 )
2018
18
MicroRNA-155, -185 and -193b as biomarkers in human papillomavirus positive and negative tonsillar and base of tongue squamous cell carcinoma. ( 29909906 )
2018
19
Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma. ( 29681158 )
2018
20
CRBP-1 over-expression is associated with poor prognosis in tongue squamous cell carcinoma. ( 29720147 )
2018
21
Long noncoding RNA GIHCG enhanced tongue squamous cell carcinoma progression through regulating miR-429. ( 29953645 )
2018
22
Epithelial mesenchymal transition induced by the CXCL9/CXCR3 axis through AKT activation promotes invasion and metastasis in tongue squamous cell carcinoma. ( 29286143 )
2018
23
Constituents of Propolis: Chrysin, Caffeic Acid, <i>p</i>-Coumaric Acid, and Ferulic Acid Induce PRODH/POX-Dependent Apoptosis in Human Tongue Squamous Cell Carcinoma Cell (CAL-27). ( 29681859 )
2018
24
IRX5 promotes NF-I_B signalling to increase proliferation, migration and invasion via OPN in tongue squamous cell carcinoma. ( 29761910 )
2018
25
Global Quantitative Proteomics reveal Deregulation of Cytoskeletal and Apoptotic Signalling Proteins in Oral Tongue Squamous Cell Carcinoma. ( 29371635 )
2018
26
Sox2 promotes tumor aggressiveness and epitheliala89mesenchymal transition in tongue squamous cell carcinoma. ( 29956740 )
2018
27
Tongue Squamous Cell Carcinoma in a European Lynx (Lynx Lynx): Papillomavirus Infection and Histologic Analysis. ( 29301274 )
2018
28
Adipose-derived stem cell conditioned medium attenuates cisplatin-triggered apoptosis in tongue squamous cell carcinoma. ( 29207154 )
2018
29
Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/I^-catenin signaling pathway. ( 29310682 )
2018
30
FoxM1 promotes epithelial-mesenchymal transition, invasion, and migration of tongue squamous cell carcinoma cells through a c-Met/AKT-dependent positive feedback loop. ( 29360662 )
2018
31
Tumor budding as a novel predictor of occult metastasis in cT2N0 tongue squamous cell carcinoma. ( 29307623 )
2018
32
Digital metastasis of tongue squamous cell carcinoma. ( 29892666 )
2018
33
A Prognostic Nomogram Incorporating Depth of Tumor Invasion to Predict Long-term Overall Survival for Tongue Squamous Cell Carcinoma With R0 Resection. ( 29937929 )
2018
34
Prognostic impact of perineural invasion in early stage oral tongue squamous cell carcinoma: Results from a prospective randomized trial. ( 29937161 )
2018
35
MicroRNA-196a-5p is a potential prognostic marker of delayed lymph node metastasis in early-stage tongue squamous cell carcinoma. ( 29434944 )
2018
36
CBX3 promotes tumor proliferation by regulating G1/S phase via p21 downregulation and associates with poor prognosis in tongue squamous cell carcinoma. ( 29462646 )
2018
37
Data on the aquaporin gene expression differences among ρ0, clinically relevant radioresistant, and the parental cells of human cervical cancer and human tongue squamous cell carcinoma. ( 30175205 )
2018
38
Nox4 Overexpression as a Poor Prognostic Factor in Patients with Oral Tongue Squamous Cell Carcinoma Receiving Surgical Resection. ( 30513726 )
2018
39
A Multicenter Retrospective Study of Elective Neck Dissection for T1-2N0M0 Tongue Squamous Cell Carcinoma: Analysis Using Propensity Score-Matching. ( 30515671 )
2018
40
Corrigendum to "Odd-skipped related transcription factor 1 (OSR1) suppresses tongue squamous cell carcinoma migration and invasion through inhibiting NF-κB pathway" [Eur. J. Pharmacol. 15 (2018) 33-39]. ( 30529035 )
2018
41
Inactivation of RUNX3 protein expression in tongue squamous cell carcinoma and its association with clinicopathological characteristics. ( 30535462 )
2018
42
Depth of invasion as a predictor of nodal disease and survival in patients with oral tongue squamous cell carcinoma. ( 30537401 )
2018
43
Tumor budding and adjacent tissue at the invasive front correlate with delayed neck metastasis in clinical early-stage tongue squamous cell carcinoma. ( 30548537 )
2018
44
CXCR4 enhances cisplatin resistance of human tongue squamous cell carcinoma. ( 30554431 )
2018
45
A novel prognostic model for tongue squamous cell carcinoma based on the characteristics of tumour and its microenvironment: iBD score. ( 30444275 )
2018
46
Immunohistochemical analysis of lymphatic vessel density and mast cells in oral tongue squamous cell carcinoma. ( 30482715 )
2018
47
SDF-1-loaded PLGA nanoparticles for the targeted photoacoustic imaging and photothermal therapy of metastatic lymph nodes in tongue squamous cell carcinoma. ( 30385376 )
2018
48
Role of Imaging in Clinically Occult Isolated Intrathyroidal Metastasis from Squamous Cell Carcinoma of Tongue: An Unusual Case Series. ( 30386055 )
2018
49
EphA8 is a Prognostic Factor for Oral Tongue Squamous Cell Carcinoma. ( 30300334 )
2018
50
Outcomes after up-front surgery and metronomic neoadjuvant chemotherapy with S-1 or UFT for early tongue squamous cell carcinoma. ( 30317400 )
2018
Sources

Variations for Tongue Squamous Cell Carcinoma

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Cosmic variations for Tongue Squamous Cell Carcinoma:

9 (show top 50) (show all 202)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)		 Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6957917 TSC2 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1120A>T p.T374S 16:2061871-2061871 12
2 COSM43708 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.422G>A p.C141Y 17:7675190-7675190 12
3 COSM10660 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 12
4 COSM10663 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.916C>T p.R306* 17:7673704-7673704 12
5 COSM10656 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 12
6 COSM10724 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.839G>C p.R280T 17:7673781-7673781 12
7 COSM43680 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.523C>T p.R175C 17:7675089-7675089 12
8 COSM10867 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.797G>A p.G266E 17:7673823-7673823 12
9 COSM10648 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 12
10 COSM11089 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.584T>C p.I195T 17:7674947-7674947 12
11 COSM43903 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.470T>G p.V157G 17:7675142-7675142 12
12 COSM10726 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.856G>A p.E286K 17:7673764-7673764 12
13 COSM44393 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.821T>C p.V274A 17:7673799-7673799 12
14 COSM43814 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.587G>C p.R196P 17:7674944-7674944 12
15 COSM10704 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 12
16 COSM10662 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.743G>A p.R248Q 17:7674220-7674220 12
17 COSM43963 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.396G>C p.K132N 17:7675216-7675216 12
18 COSM43747 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.872A>G p.K291R 17:7673748-7673748 12
19 COSM43841 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.560-1G>T p.? 17:7674972-7674972 12
20 COSM6932 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.733G>A p.G245S 17:7674230-7674230 12
21 COSM43947 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.614A>G p.Y205C 17:7674917-7674917 12
22 COSM44424 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.590T>A p.V197E 17:7674941-7674941 12
23 COSM10654 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 12
24 COSM44785 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.702C>G p.Y234* 17:7674261-7674261 12
25 COSM11450 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.644G>T p.S215I 17:7674887-7674887 12
26 COSM44567 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.647T>C p.V216A 17:7674884-7674884 12
27 COSM11196 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.734G>T p.G245V 17:7674229-7674229 12
28 COSM44411 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.608T>A p.V203E 17:7674923-7674923 12
29 COSM10834 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.711G>A p.M237I 17:7674252-7674252 12
30 COSM43621 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.809T>G p.F270C 17:7673811-7673811 12
31 COSM44351 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.572C>T p.P191L 17:7674959-7674959 12
32 COSM11073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.1024C>T p.R342* 17:7670685-7670685 12
33 COSM44262 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.808T>C p.F270L 17:7673812-7673812 12
34 COSM45132 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.783-2A>G p.? 17:7673839-7673839 12
35 COSM43695 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.748C>T p.P250S 17:7674215-7674215 12
36 COSM44523 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.863A>G p.N288S 17:7673757-7673757 12
37 COSM45135 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.673-1G>T p.? 17:7674291-7674291 12
38 COSM10859 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.814G>T p.V272L 17:7673806-7673806 12
39 COSM11066 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>T p.H193L 17:7674953-7674953 12
40 COSM10992 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.844C>G p.R282G 17:7673776-7673776 12
41 COSM10739 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.481G>A p.A161T 17:7675131-7675131 12
42 COSM11147 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.370T>C p.C124R 17:7675999-7675999 12
43 COSM10790 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.455C>T p.P152L 17:7675157-7675157 12
44 COSM44073 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.374C>A p.T125K 17:7675995-7675995 12
45 COSM10939 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.832C>T p.P278S 17:7673788-7673788 12
46 COSM10645 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>T p.C176F 17:7675085-7675085 12
47 COSM10687 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.527G>A p.C176Y 17:7675085-7675085 12
48 COSM10905 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.451C>T p.P151S 17:7675161-7675161 12
49 COSM10727 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.438G>A p.W146* 17:7675174-7675174 12
50 COSM43833 TP53 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.578A>C p.H193P 17:7674953-7674953 12
Sources

Expression for Tongue Squamous Cell Carcinoma

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LifeMap Discovery
Genes differentially expressed in tissues of Tongue Squamous Cell Carcinoma patients vs. healthy controls: 35 (show all 30)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 MMP1 matrix metallopeptidase 1 Oral Cavity + 6.95 0.000
2 TMPRSS11B transmembrane protease, serine 11B Oral Cavity - 5.73 0.000
3 MAL mal, T-cell differentiation protein Oral Cavity - 5.07 0.000
4 CRNN cornulin Oral Cavity - 4.97 0.000
5 KRT13 keratin 13, type I Oral Cavity - 4.67 0.001
6 MYH2 myosin, heavy chain 2, skeletal muscle, adult Oral Cavity - 4.12 0.005
7 PTHLH parathyroid hormone-like hormone Oral Cavity + 4.09 0.000
8 KRT17 keratin 17, type I Oral Cavity + 3.76 0.000
9 CXCL12 chemokine (C-X-C motif) ligand 12 Oral Cavity - 3.73 0.000
10 LAMC2 laminin, gamma 2 Oral Cavity + 3.68 0.000
11 CLCA4 chloride channel accessory 4 Oral Cavity - 3.65 0.000
12 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Oral Cavity + 3.44 0.000
13 LDB3 LIM domain binding 3 Oral Cavity - 3.41 0.003
14 MMP3 matrix metallopeptidase 3 Oral Cavity + 3.39 0.000
15 CLU clusterin Oral Cavity - 3.38 0.000
16 WDR66 WD repeat domain 66 Oral Cavity + 3.37 0.000
17 GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 Oral Cavity - 3.36 0.000
18 PRR9 proline rich 9 Oral Cavity + 3.34 0.004
19 CXCL8 chemokine (C-X-C motif) ligand 8 Oral Cavity + 3.33 0.000
20 CRISP3 cysteine-rich secretory protein 3 Oral Cavity - 3.23 0.010
21 CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 Oral Cavity - 3.21 0.000
22 SPINK5 serine peptidase inhibitor, Kazal type 5 Oral Cavity - 3.20 0.002
23 S100A7A S100 calcium binding protein A7A Oral Cavity + 3.15 0.001
24 IFI6 interferon, alpha-inducible protein 6 Oral Cavity + 3.13 0.000
25 INHBA inhibin, beta A Oral Cavity + 3.13 0.001
26 KRT4 keratin 4, type II Oral Cavity - 3.11 0.000
27 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 Oral Cavity - 3.10 0.000
28 FAM3B family with sequence similarity 3, member B Oral Cavity - 3.08 0.007
29 EPPK1 epiplakin 1 Oral Cavity + 3.07 0.000
30 SPRR3 small proline-rich protein 3 Oral Cavity - 3.06 0.025
Search GEO for disease gene expression data for Tongue Squamous Cell Carcinoma.
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Pathways for Tongue Squamous Cell Carcinoma

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Pathways related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Development EGFR signaling pathway 22
Show member pathways
 12.15 CASP3 CDH1 MMP2 TP53
2
Proteoglycans in cancer 37
11.86 CASP3 MIR21 MMP2 TP53
3
MicroRNAs in cancer 37
11.83 CASP3 MIR133B MIR21 MIR222 TP53
4
Colorectal Cancer Metastasis 64
11.67 CASP3 CDH1 MMP2 TP53
5
Bladder cancer 37 1
11.36 CDH1 MMP2 TP53
6
LncRNA-mediated mechanisms of therapeutic resistance 1
9.88 MEG3 TP53 UCA1
Sources

GO Terms for Tongue Squamous Cell Carcinoma

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Biological processes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 miRNA mediated inhibition of translation GO:0035278 9.13 MIR133B MIR21 MIR222
2 positive regulation of vascular smooth muscle cell proliferation GO:1904707 8.8 MIR21 MIR222 MMP2
Sources

Sources for Tongue Squamous Cell Carcinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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