MCID: TNG009
MIFTS: 44

Tongue Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Tongue Squamous Cell Carcinoma

MalaCards integrated aliases for Tongue Squamous Cell Carcinoma:

Name: Tongue Squamous Cell Carcinoma 12 15 17
Squamous Cell Carcinoma of Tongue 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050865
NCIt 49 C4648
SNOMED-CT 67 276952000
UMLS 71 C0349566

Summaries for Tongue Squamous Cell Carcinoma

Disease Ontology : 12 A head and neck squamous cell carcinoma that is located in the tongue.

MalaCards based summary : Tongue Squamous Cell Carcinoma, also known as squamous cell carcinoma of tongue, is related to tongue carcinoma and oral cavity cancer. An important gene associated with Tongue Squamous Cell Carcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways are MicroRNAs in cancer and LncRNA-mediated mechanisms of therapeutic resistance. The drugs Cetuximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include tongue, lymph node and endothelial.

Related Diseases for Tongue Squamous Cell Carcinoma

Diseases related to Tongue Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 tongue carcinoma 32.1 MIR21 MIR195 MIR139 MALAT1
2 oral cavity cancer 31.0 MIR483 MIR21 MIR195 MIR139
3 oral squamous cell carcinoma 30.9 UCA1 MIR21 MIR195 MIR139 MIR133B MEG3
4 thyroid cancer, nonmedullary, 1 30.7 MIR222 MEG3 MALAT1 HOTTIP
5 squamous cell carcinoma, head and neck 30.5 MIR483 MIR21 MIR195 MIR139 CYTOR
6 renal cell carcinoma, nonpapillary 30.3 UCA1 MIR21 MIR195 MIR139 MALAT1 CYTOR
7 esophageal cancer 29.9 UCA1 NKILA MIR483 MIR21 MIR139 MEG3
8 lung cancer susceptibility 3 29.6 MIR483 MIR21 MIR139 MEG3 MALAT1 CYTOR
9 nasopharyngeal carcinoma 29.5 NKILA MIR21 MIR139 MEG3 MALAT1 AFAP1-AS1
10 squamous cell carcinoma 11.3
11 oral cancer 10.8
12 polymyositis 10.7 MIR222 MIR21
13 small cell cancer of the lung 10.5 MIR21 MALAT1 HOTTIP
14 vulva squamous cell carcinoma 10.5 MEG3 MALAT1
15 intestinal benign neoplasm 10.5 MIR483 MIR21 MIR139
16 endocrine organ benign neoplasm 10.5 MIR483 MIR21 MIR139
17 glioma susceptibility 1 10.5 MIR222 MIR21 MEG3 MALAT1 CYTOR
18 gastrointestinal system benign neoplasm 10.5 MIR483 MIR21 MIR139
19 lymphatic system cancer 10.4 MIR483 MIR222 MIR21 MIR139
20 lymphatic system disease 10.4 MIR483 MIR222 MIR21 MIR139
21 ovary epithelial cancer 10.4 MIR483 MIR21 MIR139
22 malignant glioma 10.4 MEG3 MALAT1 HOTTIP CYTOR
23 malignant ovarian surface epithelial-stromal neoplasm 10.4 MIR483 MIR21 MIR139
24 intestinal disease 10.4 MIR483 MIR222 MIR21 MIR139
25 osteogenic sarcoma 10.4 UCA1 MEG3 MALAT1 HOTTIP
26 rectum cancer 10.4 MIR483 MIR21 MIR139
27 nervous system disease 10.4 MIR483 MIR222 MIR21 MIR139
28 bile duct disease 10.4 MIR483 MIR222 MIR139
29 nasopharyngeal disease 10.4 MIR483 MIR21 MIR139
30 cervix disease 10.4 MIR483 MIR21 MIR195 MIR139
31 connective tissue cancer 10.4 MIR483 MIR21 MIR195 MIR139
32 myeloma, multiple 10.4 UCA1 MIR483 MIR21 MEG3 MALAT1
33 biliary tract disease 10.4 MIR483 MIR222 MIR139
34 pharynx cancer 10.4 MIR483 MIR21 MIR139
35 pancreas disease 10.4 MIR483 MIR21 MIR195 MIR139
36 miyoshi muscular dystrophy 1 10.4 MIR222 MIR21
37 colonic disease 10.4 MIR483 MIR21 MIR195 MIR139
38 uterine anomalies 10.4 MIR483 MIR21 MIR195 MIR139
39 cell type benign neoplasm 10.4 MIR483 MIR21 MIR139
40 urinary system disease 10.4 MIR483 MIR21 MIR195 MIR139
41 endocrine system disease 10.4 MIR483 MIR222 MIR21 MIR195 MIR139
42 male reproductive organ cancer 10.4 MIR483 MIR222 MIR21 MIR195 MIR139
43 male reproductive system disease 10.4 MIR483 MIR222 MIR21 MIR195 MIR139
44 reproductive system disease 10.4 MIR483 MIR222 MIR21 MIR195 MIR139
45 large intestine cancer 10.4 MIR483 MIR222 MIR21 MIR195 MIR139
46 endocrine gland cancer 10.4 MIR483 MIR222 MIR21 MIR195 MIR139
47 respiratory system cancer 10.4 MIR483 MIR222 MIR21 MIR195 MIR139
48 female reproductive system disease 10.4 MIR483 MIR222 MIR21 MIR195 MIR139
49 esophageal disease 10.4 MIR483 MIR21 MIR139
50 thoracic cancer 10.4 MIR483 MIR222 MIR21 MIR195 MIR139

Graphical network of the top 20 diseases related to Tongue Squamous Cell Carcinoma:



Diseases related to Tongue Squamous Cell Carcinoma

Symptoms & Phenotypes for Tongue Squamous Cell Carcinoma

Drugs & Therapeutics for Tongue Squamous Cell Carcinoma

Drugs for Tongue Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
2 Antineoplastic Agents, Immunological Phase 1, Phase 2
3
Ribavirin Approved 36791-04-5 37542
4
Luteolin Experimental Early Phase 1 491-70-3 5280445
5 Anesthetics
6 Hemostatics
7 Antiviral Agents
8 Antimetabolites
9 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment Followed by 6 Weeks of Cetuximab+RT Post Surgery in Locally Advanced Squamous Cell Carcinoma of the Tongue ; A NEW PARADIGM OF TREATMENT Unknown status NCT01760811 Phase 1, Phase 2 Erbitux,merck serono
2 Bayesian Phase II Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer Recruiting NCT03224000 Phase 2
3 Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line: In Vitro Study Unknown status NCT03288298 Early Phase 1 luteolin;nano-luteolin
4 Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva Unknown status NCT00426062
5 Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma (Randomize Noninferiority Clinical Trial) Active, not recruiting NCT03440151
6 A Pilot Study to Assess the Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 ribavirin

Search NIH Clinical Center for Tongue Squamous Cell Carcinoma

Genetic Tests for Tongue Squamous Cell Carcinoma

Anatomical Context for Tongue Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Tongue Squamous Cell Carcinoma:

19
Tongue

MalaCards organs/tissues related to Tongue Squamous Cell Carcinoma:

40
Tongue, Lymph Node, Endothelial, T Cells, Tonsil, Skeletal Muscle, Bone

Publications for Tongue Squamous Cell Carcinoma

Articles related to Tongue Squamous Cell Carcinoma:

(show top 50) (show all 1220)
# Title Authors PMID Year
1
MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines. 46 61
19487542 2009
2
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. 61 46
18464261 2008
3
MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. 46
19509158 2009
4
AEG-1 promotes angiogenesis and may be a novel treatment target for tongue squamous cell carcinoma. 61
32031319 2020
5
Beyond Depth of Invasion: Adverse Pathologic Tumor Features in Early Oral Tongue Squamous Cell Carcinoma. 61
31411752 2020
6
Tumor-Infiltrating CD1a+ DCs and CD8+/FoxP3+ Ratios Served as Predictors for Clinical Outcomes in Tongue Squamous Cell Carcinoma Patients. 61
31606786 2020
7
Tumor histologic grade as a risk factor for neck recurrence in patients with T1-2N0 early tongue cancer. 61
32330684 2020
8
Level IV neck dissection as an elective treatment for oral tongue carcinoma-a systematic review and meta-analysis. 61
32540318 2020
9
Upregulation of long noncoding RNA FOXD2-AS1 promotes progression and predicts poor prognosis in tongue squamous cell carcinoma. 61
32531865 2020
10
High detection sensitivity and reliable morphological correlation of PET with a silicon photomultiplier for primary tongue squamous cell carcinoma. 61
32564300 2020
11
High SOX8 expression promotes tumor growth and predicts poor prognosis through GOLPH3 signaling in tongue squamous cell carcinoma. 61
32307911 2020
12
[Effects of RAB1A on the proliferation, invasion, and metastasis of tongue squamous cell carcinoma cells]. 61
32573129 2020
13
Benzo[a]pyrene promotes progression in tongue squamous cell carcinoma. 61
32557985 2020
14
Squamous Cell Carcinoma of the Oral Tongue in Young Patients: Outcomes and Implications for Treatment. 61
32523275 2020
15
CA9 transcriptional expression determines prognosis and tumour grade in tongue squamous cell carcinoma patients. 61
32299152 2020
16
Increasing incidence and improving survival of oral tongue squamous cell carcinoma. 61
32398670 2020
17
LncRNA-MALAT1 is a promising biomarker for prognostic evaluation of tongue squamous cell carcinoma. 61
32383096 2020
18
Anatomically-based transoral surgical approach to early-stage oral tongue squamous cell carcinoma. 61
32003091 2020
19
ROS enhances the cytotoxicity of cisplatin by inducing apoptosis and autophagy in tongue squamous cell carcinoma cells. 61
32097729 2020
20
Persistent and Chronic Postoperative Opioid Use in a Cohort of Patients with Oral Tongue Squamous Cell Carcinoma. 61
31609416 2020
21
Exome sequencing identifies new somatic alterations and mutation patterns of tongue squamous cell carcinoma in a Chinese population. 61
32432340 2020
22
SARS-CoV-2 detection in formalin-fixed paraffin-embedded tissue specimens from surgical resection of tongue squamous cell carcinoma. 61
32366599 2020
23
Circular RNA_0001742 has potential to predict advanced tumor stage and poor survival profiles in tongue squamous cell carcinoma management. 61
32463532 2020
24
Usefulness of fluorescence visualization-guided surgery for early-stage tongue squamous cell carcinoma compared to iodine vital staining. 61
32451767 2020
25
Knockdown of ectodysplasin-A receptor-associated adaptor protein exerts a tumor-suppressive effect in tongue squamous cell carcinoma cells. 61
32266031 2020
26
Orthotopic tongue squamous cell carcinoma (SCC) model exhibiting a different tumor-infiltrating T-cell status with margin-restricted CD8+ T cells and regulatory T cell-dominance, compared to skin SCC. 61
32204917 2020
27
Modified in-continuity resection is advantageous for prognosis and as a new surgical strategy for management of oral tongue cancer. 61
32102766 2020
28
Comparison of Clinical Results and Quality of Life in Tongue Cancer Patients Undergoing Submental Island Flap and Radial Forearm Free Flap Reconstruction. 61
32504562 2020
29
Assessment of TLR4 and TLR9 signaling and correlation with human papillomavirus status and histopathologic parameters in oral tongue squamous cell carcinoma. 61
32173390 2020
30
Elevated exosomal lysyl oxidase like 2 is a potential biomarker for head and neck squamous cell carcinoma. 61
31219623 2020
31
Asparaginase induces selective dose- and time-dependent cytotoxicity, apoptosis, and reduction of NFκB expression in oral cancer cells. 61
31943292 2020
32
Oncogenic gene RGC-32 is a direct target of miR-26b and facilitates tongue squamous cell carcinoma aggressiveness through EMT and PI3K/AKT signalling. 61
32325539 2020
33
SEMA3A Exon 9 Expression Is a Potential Prognostic Marker of Unfavorable Recurrence-Free Survival in Patients with Tongue Squamous Cell Carcinoma. 61
32074456 2020
34
Long non‑coding RNA PRNCR1 exerts oncogenic effects in tongue squamous cell carcinoma in vitro and in vivo by sponging microRNA‑944 and thereby increasing HOXB5 expression. 61
32319550 2020
35
[Effect of miR-204-5p on the proliferation, migration, and invasion on tongue squamous cell carcinoma SCC25 cells by targeting bromodomain-containing protein 4]. 61
32314893 2020
36
Knockdown of long non-coding RNA prostate cancer-associated transcript 1 inhibits the proliferation and metastasis of tongue squamous cell carcinoma cells by upregulating p21. 61
32218838 2020
37
Early tongue carcinomas (clinical stage I and II): echo-guided three-dimensional diode laser mini-invasive surgery with evaluation of histological prognostic parameters. A study of 85 cases with prolonged follow-up. 61
31834561 2020
38
The promise of immunotherapy in the treatment of young adults with oral tongue cancer. 61
32337355 2020
39
Artesunate targets oral tongue squamous cell carcinoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibition. 61
31965456 2020
40
Podoplanin is an efficient predictor of neck lymph node metastasis in tongue squamous cell carcinoma with low tumor budding grade. 61
32218810 2020
41
Exosomal miR-200c suppresses chemoresistance of docetaxel in tongue squamous cell carcinoma by suppressing TUBB3 and PPP2R1B. 61
32310826 2020
42
Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma. 61
32319610 2020
43
[Effects of farnesyltransferase silencing on the migration and invasion of tongue squamous cell carcinoma]. 61
32314892 2020
44
YY1-mediated PTEN dephosphorylation antagonizes IR-induced DNA repair contributing to tongue squamous cell carcinoma radiosensitization. 61
32334006 2020
45
Germline mutation of MDM4, a major p53 regulator, in a familial syndrome of defective telomere maintenance. 61
32300648 2020
46
Upregulation of far upstream element-binding protein 1 (FUBP1) promotes tumor proliferation and unfavorable prognosis in tongue squamous cell carcinoma. 61
32339054 2020
47
Expressions of ezrin, ERK, STAT3, and AKT in tongue cancer and association with tumor characteristics and patient survival. 61
32281236 2020
48
Comparison of supervised machine learning classification techniques in prediction of locoregional recurrences in early oral tongue cancer. 61
31923822 2020
49
Prediction of postoperative lower respiratory tract infections in tongue cancer patients based on pretreatment swallowing function. 61
31886583 2020
50
Immunohistochemical Study of PD-1/PD-L1 Axis Expression in Oral Tongue Squamous Cell Carcinomas: Effect of Neoadjuvant Chemotherapy on Local Recurrence. 61
30767115 2020

Variations for Tongue Squamous Cell Carcinoma

Cosmic variations for Tongue Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122734401 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.448C>T p.R150W 17:7673776-7673776 0

Expression for Tongue Squamous Cell Carcinoma

LifeMap Discovery
Genes differentially expressed in tissues of Tongue Squamous Cell Carcinoma patients vs. healthy controls: 35 (show all 30)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 MMP1 matrix metallopeptidase 1 Oral Cavity + 6.95 0.000
2 TMPRSS11B transmembrane protease, serine 11B Oral Cavity - 5.73 0.000
3 MAL mal, T-cell differentiation protein Oral Cavity - 5.07 0.000
4 CRNN cornulin Oral Cavity - 4.97 0.000
5 KRT13 keratin 13, type I Oral Cavity - 4.67 0.001
6 MYH2 myosin, heavy chain 2, skeletal muscle, adult Oral Cavity - 4.12 0.005
7 PTHLH parathyroid hormone-like hormone Oral Cavity + 4.09 0.000
8 KRT17 keratin 17, type I Oral Cavity + 3.76 0.000
9 CXCL12 chemokine (C-X-C motif) ligand 12 Oral Cavity - 3.73 0.000
10 LAMC2 laminin, gamma 2 Oral Cavity + 3.68 0.000
11 CLCA4 chloride channel accessory 4 Oral Cavity - 3.65 0.000
12 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Oral Cavity + 3.44 0.000
13 LDB3 LIM domain binding 3 Oral Cavity - 3.41 0.003
14 MMP3 matrix metallopeptidase 3 Oral Cavity + 3.39 0.000
15 CLU clusterin Oral Cavity - 3.38 0.000
16 WDR66 WD repeat domain 66 Oral Cavity + 3.37 0.000
17 GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 Oral Cavity - 3.36 0.000
18 PRR9 proline rich 9 Oral Cavity + 3.34 0.004
19 CXCL8 chemokine (C-X-C motif) ligand 8 Oral Cavity + 3.33 0.000
20 CRISP3 cysteine-rich secretory protein 3 Oral Cavity - 3.23 0.010
21 CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 Oral Cavity - 3.21 0.000
22 SPINK5 serine peptidase inhibitor, Kazal type 5 Oral Cavity - 3.20 0.002
23 S100A7A S100 calcium binding protein A7A Oral Cavity + 3.15 0.001
24 IFI6 interferon, alpha-inducible protein 6 Oral Cavity + 3.13 0.000
25 INHBA inhibin, beta A Oral Cavity + 3.13 0.001
26 KRT4 keratin 4, type II Oral Cavity - 3.11 0.000
27 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 Oral Cavity - 3.10 0.000
28 FAM3B family with sequence similarity 3, member B Oral Cavity - 3.08 0.007
29 EPPK1 epiplakin 1 Oral Cavity + 3.07 0.000
30 SPRR3 small proline-rich protein 3 Oral Cavity - 3.06 0.025
Search GEO for disease gene expression data for Tongue Squamous Cell Carcinoma.

Pathways for Tongue Squamous Cell Carcinoma

Pathways related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.51 MIR483 MIR222 MIR21 MIR195 MIR133B
2 10.03 UCA1 MEG3

GO Terms for Tongue Squamous Cell Carcinoma

Biological processes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 9.32 MIR483 MIR222
2 negative regulation of interleukin-21 biosynthetic process GO:0045391 9.26 MIR222 MIR21
3 miRNA mediated inhibition of translation GO:0035278 9.26 MIR483 MIR222 MIR21 MIR133B
4 gene silencing by miRNA GO:0035195 9.17 MIR483 MIR222 MIR21 MIR195 MIR139 MIR133B
5 negative regulation of interleukin-21 production GO:0032705 9.16 MIR222 MIR21

Molecular functions related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.13 MIR21 MIR133B DND1
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.02 MIR483 MIR222 MIR21 MIR195 MIR133B

Sources for Tongue Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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