MCID: TNG009
MIFTS: 44

Tongue Squamous Cell Carcinoma

Categories: Cancer diseases, Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Tongue Squamous Cell Carcinoma

MalaCards integrated aliases for Tongue Squamous Cell Carcinoma:

Name: Tongue Squamous Cell Carcinoma 12 15 17
Squamous Cell Carcinoma of Tongue 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0050865
NCIt 49 C4648
UMLS 71 C0349566

Summaries for Tongue Squamous Cell Carcinoma

Disease Ontology : 12 A head and neck squamous cell carcinoma that is located in the tongue.

MalaCards based summary : Tongue Squamous Cell Carcinoma, also known as squamous cell carcinoma of tongue, is related to oral cavity cancer and squamous cell carcinoma, head and neck. An important gene associated with Tongue Squamous Cell Carcinoma is MIR21 (MicroRNA 21), and among its related pathways/superpathways are MicroRNAs in cancer and Cell Differentiation - Index. The drugs Cetuximab and Antineoplastic Agents, Immunological have been mentioned in the context of this disorder. Affiliated tissues include tongue, lymph node and thyroid.

Related Diseases for Tongue Squamous Cell Carcinoma

Diseases related to Tongue Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 oral cavity cancer 30.9 MIR483 MIR21 MIR195 MIR181A1
2 squamous cell carcinoma, head and neck 30.4 MIR483 MIR21 MIR195 MIR181A1 CYTOR
3 tongue disease 30.1 UCA1 MIR483 MIR21 MIR195 MIR181A1 LINC00673
4 oral squamous cell carcinoma 30.1 UCA1 MIR21 MIR195 MIR181A1 MIR133B MEG3
5 thyroid cancer, nonmedullary, 1 30.0 MIR222 MALAT1 HOTTIP
6 renal cell carcinoma, nonpapillary 29.4 UCA1 MIR21 MIR195 MALAT1 CYTOR
7 esophageal cancer 29.3 UCA1 NKILA MIR21 MEG3 MALAT1 HOTTIP
8 lung cancer susceptibility 3 29.1 MIR483 MIR21 MEG3 MALAT1 CYTOR AFAP1-AS1
9 nasopharyngeal carcinoma 29.0 NKILA MIR21 MEG3 MALAT1 AFAP1-AS1
10 squamous cell carcinoma 11.3
11 tongue cancer 11.0
12 oral cancer 10.7
13 polymyositis 10.6 MIR222 MIR21
14 miyoshi muscular dystrophy 1 10.5 MIR222 MIR21
15 reproductive system disease 10.4 MIR483 MIR222 MIR21 MIR181A1
16 connective tissue cancer 10.4 MIR222 MIR21 MIR195 MIR181A1
17 bile duct adenocarcinoma 10.4 MIR483 MIR21 MIR181A1
18 pharynx cancer 10.4 MIR483 MIR222 MIR21
19 leukocyte disease 10.4 MIR483 MIR222 MIR21 MIR181A1
20 thyroid gland disease 10.4 MIR222 MIR21 MIR181A1
21 endocrine organ benign neoplasm 10.4 MIR483 MIR21 MIR181A1
22 glucose metabolism disease 10.4 MIR483 MIR222 MIR21 MIR181A1
23 arteries, anomalies of 10.4 MIR483 MIR222 MIR21 MIR181A1
24 acquired metabolic disease 10.4 MIR483 MIR222 MIR21 MIR181A1
25 obsolete: squamous cell carcinoma of head and neck 10.4
26 nervous system cancer 10.4 MIR483 MIR222 MIR21 MIR181A1
27 gonadal disease 10.4 MIR483 MIR222 MIR21 MIR181A1
28 female reproductive system disease 10.4 MIR483 MIR222 MIR21 MIR181A1
29 overnutrition 10.4 MIR483 MIR222 MIR21
30 bile duct disease 10.4 MIR483 MIR222 MIR181A1
31 biliary tract disease 10.3 MIR483 MIR222 MIR181A1
32 b-cell lymphoma 10.3
33 colonic disease 10.3 MIR483 MIR21 MIR195 MIR181A1
34 stomach disease 10.3 MIR483 MIR21 MIR195 MIR181A1
35 urinary system disease 10.3 MIR483 MIR21 MIR195 MIR181A1
36 male reproductive organ cancer 10.3 MIR483 MIR222 MIR21 MIR195 MIR181A1
37 male reproductive system disease 10.3 MIR483 MIR222 MIR21 MIR195 MIR181A1
38 squamous cell papilloma 10.3
39 papilloma 10.3
40 large intestine cancer 10.3 MIR483 MIR222 MIR21 MIR195 MIR181A1
41 thoracic cancer 10.3 MIR483 MIR222 MIR21 MIR195 MIR181A1
42 respiratory system cancer 10.3 MIR483 MIR21 MIR195 MIR181A1
43 endocrine gland cancer 10.3 MIR483 MIR222 MIR21 MIR195 MIR181A1
44 intestinal disease 10.3 MIR483 MIR222 MIR21 MIR195 MIR181A1
45 endocrine system disease 10.3 MIR483 MIR222 MIR21 MIR195 MIR181A1
46 cell type cancer 10.3 MIR483 MIR222 MIR21 MIR195 MIR181A1
47 respiratory system disease 10.3 MIR483 MIR21 MIR195 MIR181A1
48 gastrointestinal system disease 10.3 MIR483 MIR222 MIR21 MIR195 MIR181A1
49 connective tissue disease 10.3 MIR483 MIR222 MIR21 MIR181A1
50 leukoplakia 10.3

Graphical network of the top 20 diseases related to Tongue Squamous Cell Carcinoma:



Diseases related to Tongue Squamous Cell Carcinoma

Symptoms & Phenotypes for Tongue Squamous Cell Carcinoma

Drugs & Therapeutics for Tongue Squamous Cell Carcinoma

Drugs for Tongue Squamous Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
2 Antineoplastic Agents, Immunological Phase 1, Phase 2
3
Ribavirin Approved 36791-04-5 37542
4
Luteolin Experimental Early Phase 1 491-70-3 5280445
5 Hemostatics
6 Anesthetics
7 Antiviral Agents
8 Antimetabolites
9 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 CETUXIMAB Given for 3 Weeks as Neoadjuvant Treatment Followed by 6 Weeks of Cetuximab+RT Post Surgery in Locally Advanced Squamous Cell Carcinoma of the Tongue ; A NEW PARADIGM OF TREATMENT Unknown status NCT01760811 Phase 1, Phase 2 Erbitux,merck serono
2 Bayesian Phase II Trial of Magnetic Resonance Imaging Guided Radiotherapy Dose Adaptation in Human Papilloma Virus Positive Oropharyngeal Cancer Recruiting NCT03224000 Phase 2
3 Therapeutic Effect Of Luteolin Natural Extract Versus Its Nanoparticles On Tongue Squamous Cell Carcinoma Cell Line: In Vitro Study Unknown status NCT03288298 Early Phase 1 luteolin;nano-luteolin
4 Free Radical Level in SCC of Tongue Patients Tumor, Serum and Saliva Unknown status NCT00426062
5 Oncological Outcome of Contralateral Submental Artery Island Flap Versus Primary Closure in Tongue Squamous Cell Carcinoma (Randomize Noninferiority Clinical Trial) Recruiting NCT03440151
6 A Pilot Study to Assess the Pharmacodynamic Effects of Ribavirin in Patients With Tonsil and/or Base of Tongue Squamous Cell Carcinoma Active, not recruiting NCT01268579 ribavirin

Search NIH Clinical Center for Tongue Squamous Cell Carcinoma

Genetic Tests for Tongue Squamous Cell Carcinoma

Anatomical Context for Tongue Squamous Cell Carcinoma

The Foundational Model of Anatomy Ontology organs/tissues related to Tongue Squamous Cell Carcinoma:

19
Tongue

MalaCards organs/tissues related to Tongue Squamous Cell Carcinoma:

40
Tongue, Lymph Node, Thyroid, Endothelial, Lung, T Cells, Tonsil

Publications for Tongue Squamous Cell Carcinoma

Articles related to Tongue Squamous Cell Carcinoma:

(show top 50) (show all 1165)
# Title Authors PMID Year
1
MicroRNA-222 regulates cell invasion by targeting matrix metalloproteinase 1 (MMP1) and manganese superoxide dismutase 2 (SOD2) in tongue squamous cell carcinoma cell lines. 61 46
19487542 2009
2
Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. 61 46
18464261 2008
3
MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. 46
19509158 2009
4
microRNA-485-5p inhibits the progression of hepatocellular carcinoma through blocking the WBP2/Wnt signaling pathway. 61
31706018 2020
5
AEG-1 promotes angiogenesis and may be a novel treatment target for tongue squamous cell carcinoma. 61
32031319 2020
6
[Expression and significance of microRNA-125b in tongue squamous cell carcinoma]. 61
32037760 2020
7
Intracellular claudin-1 at the invasive front of tongue squamous cell carcinoma is associated with lymph node metastasis. 61
31769164 2020
8
Clinicopathological and prognostic significance of PD-1/PD-L1 axis expression in patients with tongue squamous cell carcinoma. 61
32030768 2020
9
Expression and clinical value of PD-L1 which is regulated by BRD4 in tongue squamous cell carcinoma. 61
31633227 2020
10
Bioinformatic screening and experimental analysis identify SFRP1 as a prognostic biomarker for tongue squamous cell carcinomas. 61
31734541 2020
11
Prostaglandin E2 receptor EP4 regulates cell migration through Orai1. 61
31755615 2020
12
Asparaginase induces selective dose- and time-dependent cytotoxicity, apoptosis, and reduction of NFκB expression in oral cancer cells. 61
31943292 2020
13
Inhibitory effect of the Notch pathway-inhibitor DAPT on invasion and metastasis of tongue cancer via lncRNA-KAT14 regulation. 61
31957832 2020
14
LncRNA KCNQ1OT1 contributes to the cisplatin resistance of tongue cancer through the KCNQ1OT1/miR-124-3p/TRIM14 axis. 61
31957833 2020
15
Fusobacterium nucleatum Caused DNA Damage and Promoted Cell Proliferation by the Ku70/p53 Pathway in Oral Cancer Cells. 61
31765243 2020
16
Histological characteristics of early-stage oral tongue cancer in young versus older patients: A multicenter matched-pair analysis. 61
31994277 2020
17
LncRNA CASC9 Affects Cell Proliferation, Migration, and Invasion of Tongue Squamous cell Carcinoma via Regulating miR-423-5p/SOX12 Axes. 61
32021442 2020
18
Artesunate targets oral tongue squamous cell carcinoma via mitochondrial dysfunction-dependent oxidative damage and Akt/AMPK/mTOR inhibition. 61
31965456 2020
19
Tumor depth of invasion versus tumor thickness in guiding regional nodal treatment in early oral tongue squamous cell carcinoma. 61
31606422 2020
20
Downregulation of lncRNA HOTTIP Suppresses the Proliferation, Migration, and Invasion of Oral Tongue Squamous Cell Carcinoma by Regulation of HMGA2-Mediated Wnt/β-Catenin Pathway. 61
31910357 2020
21
Integrin α7 correlates with worse clinical features and prognosis, and its knockdown inhibits cell proliferation and stemness in tongue squamous cell carcinoma. 61
31789398 2020
22
Anatomically-based transoral surgical approach to early-stage oral tongue squamous cell carcinoma. 61
32003091 2020
23
Elevated matrix metalloproteinase 7 expression promotes the proliferation, motility and metastasis of tongue squamous cell carcinoma. 61
31937294 2020
24
Progress in the study of long noncoding RNA in tongue squamous cell carcinoma. 61
31611036 2020
25
NIT2 overexpression predicts poor prognosis in tongue squamous cell carcinoma patients. 61
31925645 2020
26
First case report of tongue squamous cell carcinoma in a neurofibromatosis type 1 patient and review of pathogenesis of carcinoma in neurofibromatosis type 1. 61
32031137 2020
27
In vitro antitumor effects of FGFR and PI3K inhibitors on human papillomavirus positive and negative tonsillar and base of tongue cancer cell lines. 61
31788102 2019
28
Comparison of supervised machine learning classification techniques in prediction of locoregional recurrences in early oral tongue cancer. 61
31923822 2019
29
Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctly. 61
31830929 2019
30
Analyses of FGFR3 and PIK3CA mutations in neuroblastomas and the effects of the corresponding inhibitors on neuroblastoma cell lines. 61
31638167 2019
31
miR-429 as biomarker for diagnosis, treatment and prognosis of cancers and its potential action mechanisms: A systematic literature review. 61
31884798 2019
32
Prognostic Value of a Family History of Oral Tongue Squamous Cell Carcinoma: A Matched-Pair Study. 61
31821562 2019
33
Circ_0001742 promotes tongue squamous cell carcinoma progression via miR-431-5p/ATF3 axis. 61
31841185 2019
34
Immunohistochemical expression of TFIIH and XPF in oral tongue squamous cell carcinoma. 61
31828418 2019
35
Five extracellular matrix-associated genes upregulated in oral tongue squamous cell carcinoma: An integrated bioinformatics analysis. 61
31788070 2019
36
MRI evaluation of involvement of parotid and submandibular glands by tongue squamous cell carcinoma. 61
31901631 2019
37
Inhibition of tropomyosine receptor kinase B on the migration of human Schwann cell and dispersion of oral tongue squamous cell carcinoma in vitro. 61
31497919 2019
38
Correction to: Human papillomavirus type 18 oncoproteins exert their oncogenicity in esophageal and tongue squamous cell carcinoma cell lines distinctly. 61
31884950 2019
39
Prediction of postoperative lower respiratory tract infections in tongue cancer patients based on pretreatment swallowing function. 61
31886583 2019
40
Early tongue carcinomas (clinical stage I and II): echo-guided three-dimensional diode laser mini-invasive surgery with evaluation of histological prognostic parameters. A study of 85 cases with prolonged follow-up. 61
31834561 2019
41
Transcripto-based network analysis reveals a model of gene activation in tongue squamous cell carcinomas. 61
31589000 2019
42
Cancer-associated fibroblasts in the tumor microenvironment of tongue carcinoma is a heterogeneous cell population. 61
31604589 2019
43
Value of lingual lymph node metastasis in patients with squamous cell carcinoma of the tongue. 61
30861130 2019
44
The Potential Impact of Connexin 43 Expression on Bcl-2 Protein Level and Taxane Sensitivity in Head and Neck Cancers-In Vitro Studies. 61
31766723 2019
45
Hypermethylation of DcR1, DcR2, DR4, DR5 gene promoters and clinical significance in tongue carcinoma. 61
31399243 2019
46
miR-611 promotes the proliferation, migration and invasion of tongue squamous cell carcinoma cells by targeting FOXN3. 61
31419344 2019
47
MicroRNA-21-5p targeting PDCD4 suppresses apoptosis via regulating the PI3K/AKT/FOXO1 signaling pathway in tongue squamous cell carcinoma. 61
31602231 2019
48
Guanylate-binding protein 6 is a novel biomarker for tumorigenesis and prognosis in tongue squamous cell carcinoma. 61
31707626 2019
49
MiR-940 inhibits migration and invasion of tongue squamous cell carcinoma via regulatingCXCR2/NF-κB system-mediated epithelial-mesenchymal transition. 61
31214736 2019
50
"Tumor budding and adjacent tissue at the invasive front correlate with delayed neck metastasis in clinical early-stage tongue squamous cell carcinoma". 61
31749213 2019

Variations for Tongue Squamous Cell Carcinoma

Cosmic variations for Tongue Squamous Cell Carcinoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM122734401 upper aerodigestive tract,tongue,carcinoma,squamous cell carcinoma c.448C>T p.R150W 17:7673776-7673776 0

Expression for Tongue Squamous Cell Carcinoma

LifeMap Discovery
Genes differentially expressed in tissues of Tongue Squamous Cell Carcinoma patients vs. healthy controls: 35 (show all 30)
# Gene Description Tissue Up/Dn Fold Change (log2) P value
1 MMP1 matrix metallopeptidase 1 Oral Cavity + 6.95 0.000
2 TMPRSS11B transmembrane protease, serine 11B Oral Cavity - 5.73 0.000
3 MAL mal, T-cell differentiation protein Oral Cavity - 5.07 0.000
4 CRNN cornulin Oral Cavity - 4.97 0.000
5 KRT13 keratin 13, type I Oral Cavity - 4.67 0.001
6 MYH2 myosin, heavy chain 2, skeletal muscle, adult Oral Cavity - 4.12 0.005
7 PTHLH parathyroid hormone-like hormone Oral Cavity + 4.09 0.000
8 KRT17 keratin 17, type I Oral Cavity + 3.76 0.000
9 CXCL12 chemokine (C-X-C motif) ligand 12 Oral Cavity - 3.73 0.000
10 LAMC2 laminin, gamma 2 Oral Cavity + 3.68 0.000
11 CLCA4 chloride channel accessory 4 Oral Cavity - 3.65 0.000
12 CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) Oral Cavity + 3.44 0.000
13 LDB3 LIM domain binding 3 Oral Cavity - 3.41 0.003
14 MMP3 matrix metallopeptidase 3 Oral Cavity + 3.39 0.000
15 CLU clusterin Oral Cavity - 3.38 0.000
16 WDR66 WD repeat domain 66 Oral Cavity + 3.37 0.000
17 GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 Oral Cavity - 3.36 0.000
18 PRR9 proline rich 9 Oral Cavity + 3.34 0.004
19 CXCL8 chemokine (C-X-C motif) ligand 8 Oral Cavity + 3.33 0.000
20 CRISP3 cysteine-rich secretory protein 3 Oral Cavity - 3.23 0.010
21 CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 Oral Cavity - 3.21 0.000
22 SPINK5 serine peptidase inhibitor, Kazal type 5 Oral Cavity - 3.20 0.002
23 S100A7A S100 calcium binding protein A7A Oral Cavity + 3.15 0.001
24 IFI6 interferon, alpha-inducible protein 6 Oral Cavity + 3.13 0.000
25 INHBA inhibin, beta A Oral Cavity + 3.13 0.001
26 KRT4 keratin 4, type II Oral Cavity - 3.11 0.000
27 ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 Oral Cavity - 3.10 0.000
28 FAM3B family with sequence similarity 3, member B Oral Cavity - 3.08 0.007
29 EPPK1 epiplakin 1 Oral Cavity + 3.07 0.000
30 SPRR3 small proline-rich protein 3 Oral Cavity - 3.06 0.025
Search GEO for disease gene expression data for Tongue Squamous Cell Carcinoma.

Pathways for Tongue Squamous Cell Carcinoma

Pathways related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.59 MIR483 MIR222 MIR21 MIR195 MIR181A1 MIR133B
2 10.71 MIR222 MIR181A1 MIR133B
3 10.23 UCA1 MEG3

GO Terms for Tongue Squamous Cell Carcinoma

Biological processes related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.43 MIR483 MIR222 MIR21 MIR195 MIR181A1 MIR133B
2 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 9.26 MIR483 MIR222
3 negative regulation of reactive oxygen species biosynthetic process GO:1903427 9.16 MIR21 MIR181A1
4 miRNA mediated inhibition of translation GO:0035278 9.02 MIR483 MIR222 MIR21 MIR181A1 MIR133B

Molecular functions related to Tongue Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.1 MIR483 MIR222 MIR21 MIR195 MIR181A1 MIR133B

Sources for Tongue Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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